MCID: FBR008
MIFTS: 45

Fibrillary Astrocytoma

Categories: Rare diseases, Neuronal diseases, Cancer diseases

Aliases & Classifications for Fibrillary Astrocytoma

MalaCards integrated aliases for Fibrillary Astrocytoma:

Name: Fibrillary Astrocytoma 12 49 55 51 14 69
Diffuse Astrocytoma 12 49 55 69
Gemistocytic Astrocytoma 49 69
Protoplasmic Astrocytoma 49 69
Low-Grade Diffuse Astrocytoma 49
Fibrillary Astrocytic Tumors 12

Classifications:

Orphanet: 55  
Rare neurological diseases


External Ids:

Disease Ontology 12 DOID:6726
MeSH 41 D001254
NCIt 46 C4322
SNOMED-CT 64 253063006 71314006
UMLS via Orphanet 70 C0280785 C0334582
ICD10 via Orphanet 33 C71.9

Summaries for Fibrillary Astrocytoma

Disease Ontology : 12 An astrocytoma that is characterized as a low grade astrocytoma and has material basis in neoplastic astrocytes.

MalaCards based summary : Fibrillary Astrocytoma, also known as diffuse astrocytoma, is related to gemistocytic astrocytoma and protoplasmic astrocytoma, and has symptoms including sensory manifestations, motor manifestations and seizures. An important gene associated with Fibrillary Astrocytoma is IDH2 (Isocitrate Dehydrogenase (NADP(+)) 2, Mitochondrial), and among its related pathways/superpathways are DNA Damage and p53 Pathway (RnD). The drugs Histamine and Cyproheptadine have been mentioned in the context of this disorder. Affiliated tissues include brain and cerebellum.

Wikipedia : 72 Fibrillary astrocytomas also called low grade or diffuse astrocytomas, are a group of primary slow... more...

Related Diseases for Fibrillary Astrocytoma

Diseases related to Fibrillary Astrocytoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 98)
# Related Disease Score Top Affiliating Genes
1 gemistocytic astrocytoma 34.2 GFAP IDH2
2 protoplasmic astrocytoma 33.8 GFAP IDH2 TP53
3 astrocytoma 29.9 GFAP IDH1 KIAA1549 MGMT TP53
4 gliosarcoma 29.5 GFAP IDH1 MGMT TP53
5 interval angle-closure glaucoma 10.5 IDH1 IDH2
6 adult oligodendroglioma 10.5 IDH1 IDH2
7 enchondroma 10.5 IDH1 IDH2
8 cytogenetically normal acute myeloid leukemia 10.5 IDH1 IDH2
9 intraductal papilloma 10.5 IDH1 IDH2
10 multiple enchondromatosis, maffucci type 10.5 IDH1 IDH2
11 spindle cell hemangioma 10.5 IDH1 IDH2
12 pilocytic astrocytoma of cerebellum 10.4 IDH1 KIAA1549
13 periosteal chondrosarcoma 10.4 IDH1 IDH2
14 undifferentiated pleomorphic sarcoma 10.4 IDH1 IDH2
15 periosteal osteogenic sarcoma 10.4 IDH1 TP53
16 drug-induced mental disorder 10.4 IDH1 IDH2
17 drug psychosis 10.4 IDH1 IDH2
18 anal squamous cell carcinoma 10.4 MGMT TP53
19 squamous cell carcinoma of the larynx 10.4 PCNA TP53
20 diffuse infiltrative lymphocytosis syndrome 10.4 IDH1 IDH2
21 bone giant cell sarcoma 10.4 H3F3A TP53
22 central nervous system organ benign neoplasm 10.4 KIAA1549 TP53
23 2-hydroxyglutaric aciduria 10.4 IDH1 IDH2
24 malignant giant cell tumor 10.4 H3F3A TP53
25 testicular torsion 10.3 PCNA TP53
26 mature teratoma 10.3 PCNA TP53
27 oral leukoplakia 10.3 PCNA TP53
28 brain stem glioma 10.3 H3F3A TP53
29 brain stem cancer 10.3 H3F3A TP53
30 extraventricular neurocytoma 10.3 GFAP IDH1
31 breast papillary carcinoma 10.3 IDH1 IDH2
32 frontal convexity meningioma 10.3 GFAP TP53
33 gliofibroma 10.3 GFAP TP53
34 d-2-hydroxyglutaric aciduria 1 10.3 IDH1 IDH2
35 suppressor of tumorigenicity 3 10.3 PCNA TP53
36 cerebral convexity meningioma 10.3 GFAP TP53
37 gastric lymphoma 10.3 PCNA TP53
38 dysembryoplastic neuroepithelial tumor 10.3 GFAP IDH1
39 cellular ependymoma 10.3 GFAP TP53
40 central nervous system primitive neuroectodermal neoplasm 10.3 GFAP TP53
41 cerebral neuroblastoma 10.3 GFAP TP53
42 spinal cancer 10.3 GFAP TP53
43 intracranial chondrosarcoma 10.3 IDH1 IDH2 TP53
44 chordoid glioma 10.3 GFAP TP53
45 pilomyxoid astrocytoma 10.3 GFAP KIAA1549
46 enchondromatosis, multiple, ollier type 10.3 IDH1 IDH2
47 ependymoblastoma 10.3 GFAP TP53
48 angiocentric glioma 10.3 GFAP IDH1
49 bile duct adenocarcinoma 10.3 IDH1 IDH2 TP53
50 cerebral ventricle cancer 10.3 GFAP TP53

Graphical network of the top 20 diseases related to Fibrillary Astrocytoma:



Diseases related to Fibrillary Astrocytoma

Symptoms & Phenotypes for Fibrillary Astrocytoma

UMLS symptoms related to Fibrillary Astrocytoma:


sensory manifestations, motor manifestations, seizures, headache

Drugs & Therapeutics for Fibrillary Astrocytoma

Drugs for Fibrillary Astrocytoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 32)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Histamine Approved, Investigational Phase 3 51-45-6, 75614-87-8 774
2
Cyproheptadine Approved Phase 3 129-03-3 2913
3 Dermatologic Agents Phase 3,Phase 1
4
Histamine Phosphate Phase 3 51-74-1 65513
5
Serotonin Phase 3 50-67-9 5202
6 Serotonin Agents Phase 3
7 Serotonin Antagonists Phase 3
8 Gastrointestinal Agents Phase 3
9 Neurotransmitter Agents Phase 3
10 Histamine Antagonists Phase 3
11 Histamine H1 Antagonists Phase 3
12 Anti-Allergic Agents Phase 3
13 Antipruritics Phase 3
14
Cetuximab Approved Phase 1, Phase 2 205923-56-4 56842117 2333
15
Bevacizumab Approved, Investigational Phase 1, Phase 2 216974-75-3
16
Dacarbazine Approved, Investigational Phase 1, Phase 2 4342-03-4 5351166
17
Temozolomide Approved, Investigational Phase 1, Phase 2 85622-93-1 5394
18
Crizotinib Approved Phase 1, Phase 2 877399-52-5 11626560 10366136 10366137 10366138 10366139 10366140 10366141
19
Veliparib Investigational Phase 1, Phase 2 912444-00-9 11960529
20 Angiogenesis Inhibitors Phase 1, Phase 2
21 Angiogenesis Modulating Agents Phase 1, Phase 2
22 Alkylating Agents Phase 1, Phase 2
23 Poly(ADP-ribose) Polymerase Inhibitors Phase 1, Phase 2
24 Protein Kinase Inhibitors Phase 1, Phase 2
25
Verteporfin Approved, Investigational Phase 1 129497-78-5
26
Trioxsalen Approved Phase 1 3902-71-4 5585
27 Dihematoporphyrin Ether Phase 1
28 Photosensitizing Agents Phase 1
29
Dopamine Approved 51-61-6, 62-31-7 681
30 Fluorides
31 Dihydroxyphenylalanine
32 Dopamine Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Cyproheptadine in Preventing Weight Loss in Children Receiving Chemotherapy for Cancer Terminated NCT01132547 Phase 3 cyproheptadine hydrochloride
2 Intraarterial Infusion Of Erbitux and Bevacizumab For Relapsed/Refractory Intracranial Glioma In Patients Under 22 Recruiting NCT01884740 Phase 1, Phase 2 SIACI of Erbitux and Bevacizumab
3 Veliparib, Radiation Therapy, and Temozolomide in Treating Younger Patients With Newly Diagnosed Diffuse Pontine Gliomas Active, not recruiting NCT01514201 Phase 1, Phase 2 Temozolomide;Veliparib
4 Crizotinib in Treating Young Patients With Relapsed or Refractory Solid Tumors or Anaplastic Large Cell Lymphoma Active, not recruiting NCT00939770 Phase 1, Phase 2 crizotinib
5 Photodynamic Therapy With Porfimer Sodium in Treating Patients With Refractory Brain Tumors Unknown status NCT00002647 Phase 1 verteporfin
6 Imetelstat Sodium in Treating Young Patients With Refractory or Recurrent Solid Tumors or Lymphoma Completed NCT01273090 Phase 1 imetelstat sodium
7 18F-FDOPA PET/CT or PET/MRI in Measuring Tumors in Patients With Newly-Diagnosed or Recurrent Gliomas Terminated NCT02175745 18F-fluoro-dihydroxyphenylalanine
8 Efficacy of 68Ga-DOTATOC Positron Emission Tomography (PET) CT in Children and Young Adults With Brain Tumors Withdrawn NCT02194452

Search NIH Clinical Center for Fibrillary Astrocytoma

Genetic Tests for Fibrillary Astrocytoma

Anatomical Context for Fibrillary Astrocytoma

MalaCards organs/tissues related to Fibrillary Astrocytoma:

38
Brain, Cerebellum

Publications for Fibrillary Astrocytoma

Articles related to Fibrillary Astrocytoma:

(show all 12)
# Title Authors Year
1
Dysgeusia: an atypical and neglected psychiatric symptom induced by fibrillary astrocytoma. ( 21497786 )
2011
2
Gliosarcoma arising from a fibrillary astrocytoma. ( 21737284 )
2011
3
Concurrent solitary fibrous tumor and low-grade fibrillary astrocytoma of the cerebellum. ( 20860893 )
2010
4
An unusual tuberous sclerosis case presenting with fibrillary astrocytoma. ( 12187056 )
2002
5
BCL2 and BAX mRNA concentration profile in fibrillary astrocytoma. ( 11820596 )
2001
6
Interobserver reproducibility among neuropathologists and surgical pathologists in fibrillary astrocytoma grading. ( 10785254 )
2000
7
A clinicopathologic reappraisal of brain stem tumor classification. Identification of pilocystic astrocytoma and fibrillary astrocytoma as distinct entities. ( 11013373 )
2000
8
Fibrillary astrocytoma in a goat: pathologic, immunohistochemical, and ultrastructural study. ( 8844587 )
1996
9
Intrasellar presentation of a cystic optic chiasm fibrillary astrocytoma. ( 9309792 )
1996
10
Glial fibrillary acidic protein (GFAP): purification from human fibrillary astrocytoma, development and validation of a radioimmunoassay for GFAP-like immunoactivity. ( 438840 )
1979
11
Fibrillary astrocytoma at the base of the skull in a 5 1/2-year-old girl. ( 904938 )
1977
12
Crystal formations in ultrastructure of fibrillary astrocytoma. ( 5973794 )
1966

Variations for Fibrillary Astrocytoma

Expression for Fibrillary Astrocytoma

Search GEO for disease gene expression data for Fibrillary Astrocytoma.

Pathways for Fibrillary Astrocytoma

Pathways related to Fibrillary Astrocytoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.73 HJURP MGMT PCNA TP53
2 11.55 MGMT PCNA TP53
3 11.32 ATRX H3F3A HJURP MGMT
4 10.87 PCNA TP53
5 10.78 PCNA TP53
6
Show member pathways
10.27 IDH1 IDH2

GO Terms for Fibrillary Astrocytoma

Cellular components related to Fibrillary Astrocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleoplasm GO:0005654 9.7 ADD3 ATRX H3F3A HJURP MGMT PCNA
2 replication fork GO:0005657 8.96 PCNA TP53
3 nuclear chromosome, telomeric region GO:0000784 8.8 ATRX H3F3A PCNA

Biological processes related to Fibrillary Astrocytoma according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 cellular response to DNA damage stimulus GO:0006974 9.76 ATRX MGMT PCNA TP53
2 response to oxidative stress GO:0006979 9.58 IDH1 PCNA TP53
3 cellular response to ionizing radiation GO:0071479 9.55 MGMT TP53
4 tricarboxylic acid cycle GO:0006099 9.54 IDH1 IDH2
5 response to organic cyclic compound GO:0014070 9.54 IDH1 MGMT TP53
6 replication fork processing GO:0031297 9.52 ATRX PCNA
7 positive regulation of DNA repair GO:0045739 9.51 MGMT PCNA
8 DNA replication-independent nucleosome assembly GO:0006336 9.49 ATRX H3F3A
9 DNA methylation GO:0006306 9.48 ATRX MGMT
10 2-oxoglutarate metabolic process GO:0006103 9.43 IDH1 IDH2
11 DNA damage response, signal transduction by p53 class mediator GO:0030330 9.32 ATRX TP53
12 regulation of protein complex assembly GO:0043254 9.26 GFAP HJURP
13 DNA ligation GO:0006266 9.16 MGMT PCNA
14 isocitrate metabolic process GO:0006102 8.96 IDH1 IDH2
15 glyoxylate cycle GO:0006097 8.62 IDH1 IDH2

Molecular functions related to Fibrillary Astrocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.65 GFAP HJURP IDH1 PCNA TP53
2 NAD binding GO:0051287 9.4 IDH1 IDH2
3 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GO:0016616 9.37 IDH1 IDH2
4 histone binding GO:0042393 9.33 ATRX H3F3A HJURP
5 histone acetyltransferase binding GO:0035035 9.32 PCNA TP53
6 isocitrate dehydrogenase activity GO:0004448 8.96 IDH1 IDH2
7 isocitrate dehydrogenase (NADP+) activity GO:0004450 8.62 IDH1 IDH2

Sources for Fibrillary Astrocytoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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