MCID: FBR008
MIFTS: 45

Fibrillary Astrocytoma malady

Categories: Rare diseases, Neuronal diseases, Cancer diseases

Aliases & Classifications for Fibrillary Astrocytoma

Aliases & Descriptions for Fibrillary Astrocytoma:

Name: Fibrillary Astrocytoma 12 50 56 52 14 69
Diffuse Astrocytoma 12 50 56 69
Gemistocytic Astrocytoma 50 69
Protoplasmic Astrocytoma 50 69
Low-Grade Diffuse Astrocytoma 50
Fibrillary Astrocytic Tumors 12

Classifications:

Orphanet: 56  
Rare neurological diseases


External Ids:

Disease Ontology 12 DOID:6726
MeSH 42 D001254
NCIt 47 C4322
SNOMED-CT 64 253063006 71314006
UMLS via Orphanet 70 C0280785 C0334582
ICD10 via Orphanet 34 C71.9
UMLS 69 C0334582

Summaries for Fibrillary Astrocytoma

Disease Ontology : 12 An astrocytoma that is characterized as a low grade astrocytoma and has material basis in neoplastic astrocytes.

MalaCards based summary : Fibrillary Astrocytoma, also known as diffuse astrocytoma, is related to gemistocytic astrocytoma and protoplasmic astrocytoma, and has symptoms including headache, seizures and motor manifestations. An important gene associated with Fibrillary Astrocytoma is IDH2 (Isocitrate Dehydrogenase (NADP(+)) 2, Mitochondrial), and among its related pathways/superpathways are ErbB signaling pathway and Proteoglycans in cancer. The drugs Vincristine and Etoposide have been mentioned in the context of this disorder. Affiliated tissues include brain and cerebellum.

Wikipedia : 71 Fibrillary astrocytomas also called low grade or diffuse astrocytomas, are a group of primary slow... more...

Related Diseases for Fibrillary Astrocytoma

Diseases related to Fibrillary Astrocytoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 85)
id Related Disease Score Top Affiliating Genes
1 gemistocytic astrocytoma 12.3
2 protoplasmic astrocytoma 12.3
3 optic disk drusen 10.3 IDH1 IDH2
4 enterovesical fistula 10.3 IDH1 IDH2
5 acrocallosal syndrome 10.3 IDH1 IDH2
6 neurilemmoma 10.3 IDH1 IDH2
7 small cell osteogenic sarcoma 10.3 IDH1 IDH2
8 glycogen storage disease type 0 10.3 IDH1 IDH2
9 neuropathy, ataxia, and retinitis pigmentosa 10.3 IDH1 IDH2
10 breast papillomatosis 10.3 IDH1 IDH2
11 astrocytoma 10.3
12 pericardium leiomyoma 10.3 PCNA TP53
13 prosopagnosia 10.2 IDH1 IDH2
14 papillary tumor of the pineal region 10.2 GFAP IDH1
15 bronchial mucus gland adenoma 10.2 GFAP IDH2
16 liver fibrosarcoma 10.2 GFAP TP53
17 cervical adenoid cystic carcinoma 10.2 GFAP TP53
18 cystic lymphangioma 10.2 IDH1 IDH2
19 bronchitis 10.2 GFAP TP53
20 cervical benign neoplasm 10.2 GFAP TP53
21 well-differentiated thymic neuroendocrine carcinoma 10.2 BRAF TP53
22 adenofibroma 10.2 GFAP IDH1
23 agammaglobulinemia 8, autosomal dominant 10.2 IDH1 IDH2
24 vulvar benign neoplasm 10.2 GFAP TP53
25 endometrial squamous cell carcinoma 10.2 MGMT TP53
26 testis refractory cancer 10.2 IDH1 IDH2 TP53
27 spondylarthropathy 10.2 BRAF TP53
28 cystinosis, nephropathic 10.2 IDH1 IDH2 TP53
29 porokeratosis 10.2 GFAP TP53
30 tmem70 defect 10.2 BRAF TP53
31 basophilic carcinoma 10.2 IDH1 IDH2 TP53
32 infantile thalamic degeneration 10.2 BRAF TP53
33 adult brainstem gliosarcoma 10.2 GFAP TP53
34 scarlet fever 10.2 BRAF TP53
35 gastroesophageal junction adenocarcinoma 10.2 IDH1 IDH2 TP53
36 blood group incompatibility 10.2 GFAP TP53
37 oro-mandibular-limb hypogenesis syndrome 10.2 PCNA TP53
38 mast-cell sarcoma 10.2 GFAP TP53
39 familial hypopituitarism 10.2 BRAF TP53
40 behcet's syndrome arthropathy 10.2 GFAP PCNA
41 olfactory neuroblastoma 10.2 GFAP TP53
42 angioma hereditary neurocutaneous 10.2 IDH1 IDH2 MGMT
43 gummatous syphilis 10.2 IDH1 IDH2
44 basilar artery insufficiency 10.2 IDH1 IDH2 TP53
45 mixed epithelial stromal tumour 10.1 GFAP TP53
46 glucosephosphate isomerase deficiency 10.1 IDH1 IDH2 TP53
47 bile duct clear cell adenocarcinoma 10.1 GFAP IDH2 TP53
48 myxopapillary ependymoma 10.1 BRAF GFAP
49 biliary papillomatosis 10.1 BRAF GFAP
50 paternal uniparental disomy of chromosome 1 10.1 GFAP IDH1 TP53

Graphical network of the top 20 diseases related to Fibrillary Astrocytoma:



Diseases related to Fibrillary Astrocytoma

Symptoms & Phenotypes for Fibrillary Astrocytoma

UMLS symptoms related to Fibrillary Astrocytoma:


headache, seizures, motor manifestations, sensory manifestations

Drugs & Therapeutics for Fibrillary Astrocytoma

Drugs for Fibrillary Astrocytoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 219)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Vincristine Approved, Investigational Phase 3,Phase 2,Phase 1 2068-78-2, 57-22-7 5978
2
Etoposide Approved Phase 3,Phase 1,Phase 2 33419-42-0 36462
3
Cisplatin Approved Phase 3,Phase 2,Phase 1 15663-27-1 84093 441203 2767
4
Methotrexate Approved Phase 3 1959-05-2, 59-05-2 126941
5
Ifosfamide Approved Phase 3,Phase 1,Phase 2 3778-73-2 3690
6
Mechlorethamine Approved Phase 3,Phase 1,Phase 2 51-75-2 4033
7
Dacarbazine Approved, Investigational Phase 3,Phase 2,Phase 1 4342-03-4 5351166
8
Temozolomide Approved, Investigational Phase 3,Phase 2,Phase 1 85622-93-1 5394
9
Lomustine Approved Phase 3,Phase 2 13010-47-4 3950
10
Prednisone Approved, Vet_approved Phase 3 53-03-2 5865
11
Levoleucovorin Approved Phase 3,Phase 1 68538-85-2
12
Donepezil Approved Phase 3 120014-06-4 3152
13
Procarbazine Approved Phase 2, Phase 3 671-16-9 4915
14
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
15
Histamine Approved, Investigational Phase 3 75614-87-8, 51-45-6 774
16
Cyproheptadine Approved Phase 3 129-03-3 2913
17
leucovorin Approved, Nutraceutical Phase 3,Phase 1 58-05-9 54575, 6560146 143
18
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3,Phase 2,Phase 1 59-30-3 6037
19 Alkylating Agents Phase 3,Phase 2,Phase 1
20 glucocorticoids Phase 3
21 Folic Acid Antagonists Phase 3
22 Topoisomerase Inhibitors Phase 3,Phase 1,Phase 2
23 Nucleic Acid Synthesis Inhibitors Phase 3,Phase 2
24 Dermatologic Agents Phase 3,Phase 1
25 Hormone Antagonists Phase 3,Phase 2
26 Hormones Phase 3,Phase 2,Phase 1
27 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 2
28 Vitamin B Complex Phase 3,Phase 2,Phase 1
29 Etoposide phosphate Phase 3,Phase 1,Phase 2
30 Immunosuppressive Agents Phase 3,Phase 1,Phase 2
31 Anti-Inflammatory Agents Phase 3
32 Isophosphamide mustard Phase 3,Phase 1,Phase 2
33 Antimetabolites Phase 3,Phase 1
34 Antimetabolites, Antineoplastic Phase 3
35 Antimitotic Agents Phase 3,Phase 2,Phase 1
36 Antirheumatic Agents Phase 3
37 Antineoplastic Agents, Alkylating Phase 3,Phase 2,Phase 1
38 Antineoplastic Agents, Hormonal Phase 3,Phase 2,Phase 1
39 Antineoplastic Agents, Phytogenic Phase 3,Phase 2,Phase 1
40 Calcium, Dietary Phase 3,Phase 2,Phase 1
41 pancreatic polypeptide Phase 3,Phase 1
42 Analgesics Phase 3,Phase 2
43 Cholinergic Agents Phase 3
44 Adjuvants, Anesthesia Phase 3
45 Cholinesterase Inhibitors Phase 3
46 Narcotics Phase 3
47 Gastrointestinal Agents Phase 3,Phase 1,Early Phase 1
48 Neurotransmitter Agents Phase 3,Phase 2
49 Nootropic Agents Phase 3,Phase 2
50 Analgesics, Opioid Phase 3

Interventional clinical trials:

(show top 50) (show all 105)
id Name Status NCT ID Phase
1 Combination Chemotherapy and Radiation Therapy With or Without Methotrexate in Treating Young Patients With Newly Diagnosed Gliomas Unknown status NCT00278278 Phase 3
2 Radiation Therapy or Temozolomide in Treating Patients With Gliomas Completed NCT00182819 Phase 3
3 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3
4 Donepezil in Treating Patients Who Have Undergone Radiation Therapy for Brain Tumors Completed NCT00369785 Phase 3
5 Radiation Therapy With or Without Temozolomide in Treating Patients With Low-Grade Glioma Recruiting NCT00978458 Phase 3
6 Observation or Radiation Therapy With or Without Combination Chemotherapy in Treating Patients With Low-Grade Glioma Active, not recruiting NCT00003375 Phase 2, Phase 3
7 Cyproheptadine in Preventing Weight Loss in Children Receiving Chemotherapy for Cancer Terminated NCT01132547 Phase 3
8 Antineoplaston Therapy in Treating Patients With Low-Grade Astrocytoma Unknown status NCT00003471 Phase 2
9 Chemotherapy Followed by Radiation Therapy in Treating Adults With Supratentorial Glioma Completed NCT00002806 Phase 2
10 Phase II Imatinib + Hydroxyurea in Treatment of Patients With Recurrent/Progressive Grade II Low-Grade Glioma (LGG) Completed NCT00615927 Phase 2
11 Temozolomide in Treating Patients With Low-Grade Glioma Completed NCT00313729 Phase 2
12 Irinotecan in Treating Patients With Progressive or Recurrent Malignant Glioma Completed NCT00003616 Phase 1, Phase 2
13 Irinotecan in Treating Patients With Recurrent Glioma Completed NCT00003134 Phase 2
14 Sunitinib in Treating Patients With Recurrent Malignant Gliomas Completed NCT00499473 Phase 2
15 Erlotinib and Temsirolimus in Treating Patients With Recurrent Malignant Glioma Completed NCT00112736 Phase 1, Phase 2
16 Bevacizumab in Reducing CNS Side Effects in Patients Who Have Undergone Radiation Therapy to the Brain for Primary Brain Tumor, Meningioma, or Head and Neck Cancer Completed NCT00492089 Phase 2
17 Magnetic Resonance Imaging and Magnetic Resonance Spectroscopic Imaging in Evaluating Patients Who Are Undergoing Treatment for Gliomas Completed NCT00274755 Phase 2
18 Biological Therapy Following Surgery and Radiation Therapy in Treating Patients With Primary or Recurrent Astrocytoma or Oligodendroglioma Completed NCT00004024 Phase 2
19 Levetiracetam or Pregabalin in Treating Seizures in Patients Undergoing Chemotherapy and/or Radiation Therapy For Primary Brain Tumors Completed NCT00629889 Phase 2
20 Tamoxifen, Carboplatin, and Topotecan in Treating Patients With CNS Metastases or Recurrent Brain or Spinal Cord Tumors Completed NCT00541138 Phase 2
21 Temozolomide in Treating Patients With Recurrent Glioblastoma Multiforme or Other Malignant Glioma Completed NCT00498927 Phase 2
22 Combination Chemotherapy and Tamoxifen in Treating Patients With Solid Tumors Completed NCT00002608 Phase 2
23 Armodafinil in Treating Fatigue Caused By Radiation Therapy in Patients With Primary Brain Tumors Completed NCT01032200 Phase 2
24 Imatinib Mesylate in Treating Patients With Gliomas Completed NCT00039364 Phase 2
25 Temozolomide in Treating Patients With Progressive Low-Grade Glioma Completed NCT00003466 Phase 2
26 Chemotherapy and Radiation Therapy After Surgery in Treating Children With Newly Diagnosed Astrocytoma, Glioblastoma Multiforme, Gliosarcoma, or Diffuse Intrinsic Pontine Glioma Completed NCT00028795 Phase 2
27 Imetelstat Sodium in Treating Younger Patients With Recurrent or Refractory Brain Tumors Completed NCT01836549 Phase 2
28 Bevacizumab and Irinotecan in Treating Young Patients With Recurrent, Progressive, or Refractory Glioma, Medulloblastoma, Ependymoma, or Low Grade Glioma Completed NCT00381797 Phase 2
29 Chemotherapy Followed by Bone Marrow or Peripheral Stem Cell Transplantation in Treating Patients With Glioblastoma Multiforme or Brain Stem Tumors Completed NCT00002619 Phase 2
30 Study to Assess Safety, Pharmacokinetics, and Efficacy of Oral CC-223 for Patients With Advanced Solid Tumors, Non-Hodgkin Lymphoma or Multiple Myeloma Completed NCT01177397 Phase 1, Phase 2
31 Everolimus With and Without Temozolomide in Adult Low Grade Glioma Recruiting NCT02023905 Phase 2
32 Proton Beam or Intensity-Modulated Radiation Therapy in Preserving Brain Function in Patients With IDH Mutant Grade II or III Glioma Recruiting NCT03180502 Phase 2
33 A Phase I Study of Mebendazole for the Treatment of Pediatric Gliomas Recruiting NCT01837862 Phase 1, Phase 2
34 Prolonged Exposure to Doxorubicin in Patients With Glioblastoma Multiforme and Diffuse Intrinsic Pontine Glioma Recruiting NCT02758366 Phase 2
35 Intraarterial Infusion Of Erbitux and Bevacizumab For Relapsed/Refractory Intracranial Glioma In Patients Under 22 Recruiting NCT01884740 Phase 1, Phase 2
36 A Study of DSP-7888 in Pediatric Patients With Relapsed or Refractory High Grade Gliomas Recruiting NCT02750891 Phase 1, Phase 2
37 A Study of the Safety, Tolerability, and Efficacy of Epacadostat Administered in Combination With Nivolumab in Select Advanced Cancers (ECHO-204) Recruiting NCT02327078 Phase 1, Phase 2
38 Adult Study: ABT-414 Alone or ABT-414 Plus Temozolomide vs. Lomustine or Temozolomide for Recurrent Glioblastoma Pediatric Study: Evaluation of ABT-414 in Children With High Grade Gliomas Recruiting NCT02343406 Phase 2
39 Temozolomide and Radiation Therapy in Treating Patients With Gliomas Active, not recruiting NCT00114140 Phase 2
40 Vaccine for Patients With Newly Diagnosed or Recurrent Low-Grade Glioma Active, not recruiting NCT01635283 Phase 2
41 Temsirolimus and Perifosine in Treating Patients With Recurrent or Progressive Malignant Glioma Active, not recruiting NCT01051557 Phase 1, Phase 2
42 Proton Beam Radiation Therapy in Treating Patients With Low Grade Gliomas Active, not recruiting NCT01024907 Phase 1, Phase 2
43 External Beam Radiation Therapy and Cetuximab Followed by Irinotecan and Cetuximab for Children and Young Adults With Newly Diagnosed Diffuse Pontine Tumors and High-Grade Astrocytomas Active, not recruiting NCT01012609 Phase 2
44 Bevacizumab in Recurrent Grade II and III Glioma Active, not recruiting NCT01164189 Phase 2
45 Everolimus, Temozolomide, and Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma Active, not recruiting NCT00553150 Phase 1, Phase 2
46 Iodine I 131 Monoclonal Antibody 3F8 in Treating Patients With Central Nervous System Cancer or Leptomeningeal Cancer Active, not recruiting NCT00445965 Phase 2
47 Valproic Acid and Radiation Followed by Maintenance Valproic Acid and Bevacizumab in Children With High Grade Gliomas or Diffuse Intrinsic Pontine Glioma Active, not recruiting NCT00879437 Phase 2
48 Veliparib, Radiation Therapy, and Temozolomide in Treating Younger Patients With Newly Diagnosed Diffuse Pontine Gliomas Active, not recruiting NCT01514201 Phase 1, Phase 2
49 Vorinostat and Radiation Therapy Followed by Maintenance Therapy With Vorinostat in Treating Younger Patients With Newly Diagnosed Diffuse Intrinsic Pontine Glioma Active, not recruiting NCT01189266 Phase 1, Phase 2
50 Dasatinib, Ifosfamide, Carboplatin, and Etoposide in Treating Young Patients With Metastatic or Recurrent Malignant Solid Tumors Active, not recruiting NCT00788125 Phase 1, Phase 2

Search NIH Clinical Center for Fibrillary Astrocytoma

Genetic Tests for Fibrillary Astrocytoma

Anatomical Context for Fibrillary Astrocytoma

MalaCards organs/tissues related to Fibrillary Astrocytoma:

39
Brain, Cerebellum

Publications for Fibrillary Astrocytoma

Articles related to Fibrillary Astrocytoma:

(show all 12)
id Title Authors Year
1
Dysgeusia: an atypical and neglected psychiatric symptom induced by fibrillary astrocytoma. ( 21497786 )
2011
2
Gliosarcoma arising from a fibrillary astrocytoma. ( 21737284 )
2011
3
Concurrent solitary fibrous tumor and low-grade fibrillary astrocytoma of the cerebellum. ( 20860893 )
2010
4
An unusual tuberous sclerosis case presenting with fibrillary astrocytoma. ( 12187056 )
2002
5
BCL2 and BAX mRNA concentration profile in fibrillary astrocytoma. ( 11820596 )
2001
6
Interobserver reproducibility among neuropathologists and surgical pathologists in fibrillary astrocytoma grading. ( 10785254 )
2000
7
A clinicopathologic reappraisal of brain stem tumor classification. Identification of pilocystic astrocytoma and fibrillary astrocytoma as distinct entities. ( 11013373 )
2000
8
Fibrillary astrocytoma in a goat: pathologic, immunohistochemical, and ultrastructural study. ( 8844587 )
1996
9
Intrasellar presentation of a cystic optic chiasm fibrillary astrocytoma. ( 9309792 )
1996
10
Glial fibrillary acidic protein (GFAP): purification from human fibrillary astrocytoma, development and validation of a radioimmunoassay for GFAP-like immunoactivity. ( 438840 )
1979
11
Fibrillary astrocytoma at the base of the skull in a 5 1/2-year-old girl. ( 904938 )
1977
12
Crystal formations in ultrastructure of fibrillary astrocytoma. ( 5973794 )
1966

Variations for Fibrillary Astrocytoma

Expression for Fibrillary Astrocytoma

Search GEO for disease gene expression data for Fibrillary Astrocytoma.

Pathways for Fibrillary Astrocytoma

Pathways related to Fibrillary Astrocytoma according to GeneCards Suite gene sharing:

(show all 11)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
11.99 BRAF CAMK2G TP53
2 11.96 BRAF CAMK2G TP53
3 11.67 MGMT PCNA TP53
4 11.54 BRAF MGMT TP53
5 11.39 HJURP MGMT PCNA TP53
6 11.36 BRAF PCNA TP53
7 11.06 BRAF CAMK2G TP53
8 10.96 PCNA TP53
9 10.9 PCNA TP53
10 10.87 BRAF TP53
11
Show member pathways
10.37 IDH1 IDH2

GO Terms for Fibrillary Astrocytoma

Cellular components related to Fibrillary Astrocytoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 replication fork GO:0005657 8.62 PCNA TP53

Biological processes related to Fibrillary Astrocytoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cellular response to ionizing radiation GO:0071479 9.43 MGMT TP53
2 tricarboxylic acid cycle GO:0006099 9.4 IDH1 IDH2
3 positive regulation of DNA repair GO:0045739 9.37 MGMT PCNA
4 2-oxoglutarate metabolic process GO:0006103 9.32 IDH1 IDH2
5 regulation of protein complex assembly GO:0043254 9.26 GFAP HJURP
6 DNA ligation GO:0006266 9.16 MGMT PCNA
7 isocitrate metabolic process GO:0006102 8.96 IDH1 IDH2
8 glyoxylate cycle GO:0006097 8.62 IDH1 IDH2

Molecular functions related to Fibrillary Astrocytoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.55 BRAF GFAP HJURP PCNA TP53
2 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GO:0016616 9.32 IDH1 IDH2
3 histone acetyltransferase binding GO:0035035 9.26 PCNA TP53
4 isocitrate dehydrogenase (NADP+) activity GO:0004450 8.96 IDH1 IDH2
5 isocitrate dehydrogenase activity GO:0004448 8.62 IDH1 IDH2

Sources for Fibrillary Astrocytoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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