MCID: FBR008
MIFTS: 41

Fibrillary Astrocytoma

Categories: Rare diseases, Neuronal diseases, Cancer diseases

Aliases & Classifications for Fibrillary Astrocytoma

MalaCards integrated aliases for Fibrillary Astrocytoma:

Name: Fibrillary Astrocytoma 12 50 56 52 14 69
Diffuse Astrocytoma 12 50 56 69
Gemistocytic Astrocytoma 50 69
Protoplasmic Astrocytoma 50 69
Low-Grade Diffuse Astrocytoma 50
Fibrillary Astrocytic Tumors 12

Classifications:

Orphanet: 56  
Rare neurological diseases


External Ids:

Disease Ontology 12 DOID:6726
MeSH 42 D001254
NCIt 47 C4322
SNOMED-CT 64 253063006 71314006
UMLS via Orphanet 70 C0280785 C0334582
ICD10 via Orphanet 34 C71.9
UMLS 69 C0334582

Summaries for Fibrillary Astrocytoma

Disease Ontology : 12 An astrocytoma that is characterized as a low grade astrocytoma and has material basis in neoplastic astrocytes.

MalaCards based summary : Fibrillary Astrocytoma, also known as diffuse astrocytoma, is related to gemistocytic astrocytoma and protoplasmic astrocytoma, and has symptoms including headache, seizures and motor manifestations. An important gene associated with Fibrillary Astrocytoma is IDH2 (Isocitrate Dehydrogenase (NADP(+)) 2, Mitochondrial), and among its related pathways/superpathways are p53 Pathway (RnD) and DNA Damage. The drugs Cyproheptadine and Histamine have been mentioned in the context of this disorder. Affiliated tissues include brain and cerebellum.

Wikipedia : 72 Fibrillary astrocytomas also called low grade or diffuse astrocytomas, are a group of primary slow... more...

Related Diseases for Fibrillary Astrocytoma

Diseases related to Fibrillary Astrocytoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 99)
id Related Disease Score Top Affiliating Genes
1 gemistocytic astrocytoma 12.3
2 protoplasmic astrocytoma 12.3
3 optic disk drusen 10.8 IDH1 IDH2
4 nemaline myopathy 10.8 IDH1 IDH2
5 endolymphatic sac tumor 10.8 IDH1 IDH2
6 essential pentosuria 10.7 IDH1 IDH2
7 breast papillomatosis 10.7 IDH1 IDH2
8 acute pre-b-cell lymphoblastic leukemia 10.7 IDH1 IDH2
9 neurotic disorder 10.7 IDH1 IDH2
10 pineal gland astrocytoma 10.7 IDH1 KIAA1549
11 juxtacortical chondrosarcoma 10.7 IDH1 IDH2
12 rectum squamous cell carcinoma 10.6 MGMT TP53
13 breast epithelioid hemangioma 10.6 IDH1 TP53
14 allergic hypersensitivity disease 10.6 IDH1 IDH2
15 leiomyoma cutis 10.6 PCNA TP53
16 vascular cancer 10.6 IDH1 IDH2
17 achard syndrome 10.6 IDH1 IDH2
18 brain edema 10.6 H3F3A TP53
19 immune system organ benign neoplasm 10.6 KIAA1549 TP53
20 hemangioma of liver 10.6 H3F3A TP53
21 brachydactyly 10.5 IDH1 IDH2
22 brainstem intraparenchymal clear cell meningioma 10.5 H3F3A TP53
23 childhood infratentorial neoplasm 10.5 H3F3A TP53
24 ovarian mucinous cystadenofibroma 10.5 GFAP IDH2
25 hypogonadotropic hypogonadism-frontoparietal alopecia syndrome 10.5 GFAP IDH1
26 malignant syringoma 10.5 PCNA TP53
27 orbital lymphoma 10.5 PCNA TP53
28 pancoast tumor 10.5 GFAP TP53
29 brain stem astrocytic neoplasm 10.5 GFAP TP53
30 fallopian tube papillary adenocarcinoma 10.5 IDH1 IDH2
31 pylorus cancer 10.5 PCNA TP53
32 renal pelvis urothelial papilloma 10.5 GFAP TP53
33 adenofibroma 10.5 GFAP IDH1
34 brain glioma 10.5 GFAP TP53
35 mixed oligodendroglioma-astrocytoma 10.5 IDH1 IDH2 TP53
36 rh isoimmunization 10.5 GFAP TP53
37 cerebellar astrocytoma 10.5 GFAP KIAA1549
38 third cranial nerve disease 10.5 GFAP TP53
39 pleural empyema 10.5 GFAP TP53
40 aggressive systemic mastocytosis 10.4 GFAP TP53
41 peritoneal serous adenocarcinoma 10.4 IDH1 IDH2 TP53
42 childhood choroid plexus cancer 10.4 GFAP TP53
43 papillary glioneuronal tumor 10.4 GFAP IDH1
44 brachial plexus neuritis 10.4 GFAP TP53
45 apocrine adenocarcinoma 10.4 IDH1 IDH2 TP53
46 fryns macrocephaly 10.4 IDH1 IDH2
47 subependymal giant cell astrocytoma 10.4 GFAP TP53
48 childhood oligodendroglioma 10.4 PCNA TP53
49 pineoblastoma 10.4 GFAP TP53
50 malignant spindle cell melanoma 10.4 MGMT TP53

Graphical network of the top 20 diseases related to Fibrillary Astrocytoma:



Diseases related to Fibrillary Astrocytoma

Symptoms & Phenotypes for Fibrillary Astrocytoma

UMLS symptoms related to Fibrillary Astrocytoma:


headache, seizures, motor manifestations, sensory manifestations

Drugs & Therapeutics for Fibrillary Astrocytoma

Drugs for Fibrillary Astrocytoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 43)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cyproheptadine Approved Phase 3 129-03-3 2913
2
Histamine Approved, Investigational Phase 3 75614-87-8, 51-45-6 774
3 Dermatologic Agents Phase 3,Phase 1
4 Anti-Allergic Agents Phase 3
5 Antipruritics Phase 3
6 Gastrointestinal Agents Phase 3
7 Histamine Antagonists Phase 3
8 Histamine H1 Antagonists Phase 3
9
Histamine Phosphate Phase 3 51-74-1 65513
10 Neurotransmitter Agents Phase 3
11
Serotonin Phase 3 50-67-9 5202
12 Serotonin Agents Phase 3
13 Serotonin Antagonists Phase 3
14
Bevacizumab Approved, Investigational Phase 1, Phase 2 216974-75-3
15
Cetuximab Approved Phase 1, Phase 2 205923-56-4 56842117 2333
16
Dacarbazine Approved, Investigational Phase 1, Phase 2 4342-03-4 5351166
17
Temozolomide Approved, Investigational Phase 1, Phase 2 85622-93-1 5394
18
Crizotinib Approved Phase 1, Phase 2 877399-52-5 11626560 10366136 10366137 10366138 10366139 10366140 10366141
19
Veliparib Investigational Phase 1, Phase 2 912444-00-9 11960529
20 Angiogenesis Inhibitors Phase 1, Phase 2
21 Angiogenesis Modulating Agents Phase 1, Phase 2
22 Alkylating Agents Phase 1, Phase 2
23 Poly(ADP-ribose) Polymerase Inhibitors Phase 1, Phase 2
24 Protein Kinase Inhibitors Phase 1, Phase 2
25
Trioxsalen Approved Phase 1 3902-71-4 5585
26
Verteporfin Approved, Investigational Phase 1 129497-78-5
27
Folic Acid Approved, Nutraceutical, Vet_approved Phase 1 59-30-3 6037
28
Niacin Approved, Investigational, Nutraceutical Phase 1 59-67-6 938
29
Nicotinamide Approved, Nutraceutical Phase 1 98-92-0 936
30 Dihematoporphyrin Ether Phase 1
31 Photosensitizing Agents Phase 1
32 Micronutrients Phase 1
33 Nicotinic Acids Phase 1
34 Trace Elements Phase 1
35 Vitamin B Complex Phase 1
36 Vitamins Phase 1
37 Folate Nutraceutical Phase 1
38 Vitamin B3 Nutraceutical Phase 1
39 Vitamin B9 Nutraceutical Phase 1
40
Dopamine Approved 51-61-6, 62-31-7 681
41 Dihydroxyphenylalanine
42 Dopamine Agents
43 Fluorides

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Cyproheptadine in Preventing Weight Loss in Children Receiving Chemotherapy for Cancer Terminated NCT01132547 Phase 3 cyproheptadine hydrochloride
2 Intraarterial Infusion Of Erbitux and Bevacizumab For Relapsed/Refractory Intracranial Glioma In Patients Under 22 Recruiting NCT01884740 Phase 1, Phase 2 SIACI of Erbitux and Bevacizumab
3 Veliparib, Radiation Therapy, and Temozolomide in Treating Younger Patients With Newly Diagnosed Diffuse Pontine Gliomas Active, not recruiting NCT01514201 Phase 1, Phase 2 Temozolomide;Veliparib
4 Crizotinib in Treating Young Patients With Relapsed or Refractory Solid Tumors or Anaplastic Large Cell Lymphoma Active, not recruiting NCT00939770 Phase 1, Phase 2 crizotinib
5 Photodynamic Therapy With Porfimer Sodium in Treating Patients With Refractory Brain Tumors Unknown status NCT00002647 Phase 1 verteporfin
6 Imetelstat Sodium in Treating Young Patients With Refractory or Recurrent Solid Tumors or Lymphoma Completed NCT01273090 Phase 1 imetelstat sodium
7 18F-FDOPA PET/CT or PET/MRI in Measuring Tumors in Patients With Newly-Diagnosed or Recurrent Gliomas Terminated NCT02175745 18F-fluoro-dihydroxyphenylalanine
8 Efficacy of 68Ga-DOTATOC Positron Emission Tomography (PET) CT in Children and Young Adults With Brain Tumors Withdrawn NCT02194452

Search NIH Clinical Center for Fibrillary Astrocytoma

Genetic Tests for Fibrillary Astrocytoma

Anatomical Context for Fibrillary Astrocytoma

MalaCards organs/tissues related to Fibrillary Astrocytoma:

39
Brain, Cerebellum

Publications for Fibrillary Astrocytoma

Articles related to Fibrillary Astrocytoma:

(show all 12)
id Title Authors Year
1
Dysgeusia: an atypical and neglected psychiatric symptom induced by fibrillary astrocytoma. ( 21497786 )
2011
2
Gliosarcoma arising from a fibrillary astrocytoma. ( 21737284 )
2011
3
Concurrent solitary fibrous tumor and low-grade fibrillary astrocytoma of the cerebellum. ( 20860893 )
2010
4
An unusual tuberous sclerosis case presenting with fibrillary astrocytoma. ( 12187056 )
2002
5
BCL2 and BAX mRNA concentration profile in fibrillary astrocytoma. ( 11820596 )
2001
6
A clinicopathologic reappraisal of brain stem tumor classification. Identification of pilocystic astrocytoma and fibrillary astrocytoma as distinct entities. ( 11013373 )
2000
7
Interobserver reproducibility among neuropathologists and surgical pathologists in fibrillary astrocytoma grading. ( 10785254 )
2000
8
Intrasellar presentation of a cystic optic chiasm fibrillary astrocytoma. ( 9309792 )
1996
9
Fibrillary astrocytoma in a goat: pathologic, immunohistochemical, and ultrastructural study. ( 8844587 )
1996
10
Glial fibrillary acidic protein (GFAP): purification from human fibrillary astrocytoma, development and validation of a radioimmunoassay for GFAP-like immunoactivity. ( 438840 )
1979
11
Fibrillary astrocytoma at the base of the skull in a 5 1/2-year-old girl. ( 904938 )
1977
12
Crystal formations in ultrastructure of fibrillary astrocytoma. ( 5973794 )
1966

Variations for Fibrillary Astrocytoma

Expression for Fibrillary Astrocytoma

Search GEO for disease gene expression data for Fibrillary Astrocytoma.

Pathways for Fibrillary Astrocytoma

Pathways related to Fibrillary Astrocytoma according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.46 MGMT PCNA TP53
2 11.39 HJURP MGMT PCNA TP53
3 10.83 PCNA TP53
4 10.72 PCNA TP53
5
Show member pathways
10.07 IDH1 IDH2

GO Terms for Fibrillary Astrocytoma

Cellular components related to Fibrillary Astrocytoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 nucleoplasm GO:0005654 9.5 ADD3 CAMK2G H3F3A HJURP MGMT PCNA
2 replication fork GO:0005657 8.62 PCNA TP53

Biological processes related to Fibrillary Astrocytoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cellular response to ionizing radiation GO:0071479 9.43 MGMT TP53
2 tricarboxylic acid cycle GO:0006099 9.4 IDH1 IDH2
3 positive regulation of DNA repair GO:0045739 9.37 MGMT PCNA
4 2-oxoglutarate metabolic process GO:0006103 9.32 IDH1 IDH2
5 regulation of protein complex assembly GO:0043254 9.26 GFAP HJURP
6 DNA ligation GO:0006266 9.16 MGMT PCNA
7 isocitrate metabolic process GO:0006102 8.96 IDH1 IDH2
8 glyoxylate cycle GO:0006097 8.62 IDH1 IDH2

Molecular functions related to Fibrillary Astrocytoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 NAD binding GO:0051287 9.32 IDH1 IDH2
2 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GO:0016616 9.26 IDH1 IDH2
3 histone acetyltransferase binding GO:0035035 9.16 PCNA TP53
4 isocitrate dehydrogenase (NADP+) activity GO:0004450 8.96 IDH1 IDH2
5 isocitrate dehydrogenase activity GO:0004448 8.62 IDH1 IDH2

Sources for Fibrillary Astrocytoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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