TCP
MCID: FBR063
MIFTS: 45

Fibrocalculous Pancreatic Diabetes (TCP) malady

Genetic diseases, Gastrointestinal diseases, Rare diseases, Endocrine diseases categories
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Summaries for Fibrocalculous Pancreatic Diabetes

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MalaCards based summary: Fibrocalculous Pancreatic Diabetes, also known as TCP, is related to pancreatitis and hepatitis, and has symptoms including An important gene associated with Fibrocalculous Pancreatic Diabetes is SPINK1 (serine peptidase inhibitor, Kazal type 1), and among its related pathways are HIF-1 signaling pathway and Insulin receptor recycling. The compounds potassium chloride and chromium picolinate have been mentioned in the context of this disorder. Affiliated tissues include pancreatic islet, and related mouse phenotypes are mortality/aging and endocrine/exocrine gland.

Description from OMIM:46 608189

Aliases & Classifications for Fibrocalculous Pancreatic Diabetes

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Sources:
46OMIM, 62UMLS, 48Orphanet, 26ICD10 via Orphanet
See all sources

Fibrocalculous Pancreatic Diabetes, Aliases & Descriptions:

Name: Fibrocalculous Pancreatic Diabetes 46 62
Tcp 48 62
 
Tropical Calcific Chronic Pancreatitis 48
Tropical Pancreatitis 48


Classifications:



Characteristics (Orphanet epidemiological data):

48
tcp:
Age of onset: Childhood


External Ids:

OMIM46 608189
ICD10 via Orphanet26 K86.1

Related Diseases for Fibrocalculous Pancreatic Diabetes

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Diseases related to Fibrocalculous Pancreatic Diabetes via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 58)
idRelated DiseaseScoreTop Affiliating Genes
1pancreatitis30.9CTRC, ALB, REG1A, INS, SPINK1
2hepatitis30.5TF, ALB
3autonomic neuropathy30.4ALB, INS
4neuropathy30.1ALB, INS
5diabetes mellitus29.9SPINK1, TF, INS, REG1A, ALB
6tropical calcific pancreatitis10.5SPINK1
7fibrocalculous pancreatopathy10.4
8hereditary pancreatitis10.3REG1A, SPINK1
9cataract10.3
10obesity10.3
11hemiplegia10.3
12autonomic dysfunction10.3
13insulin resistance10.3
14pancreas disease10.3REG1A, SPINK1
15acute pancreatitis10.2SPINK1, REG1A
16pancreatitis, chronic10.2SPINK1, REG1A
17bone fracture10.2
18pancreatic cancer10.2VIP, SPINK1
19hypokalemia10.1INS, VIP
20acromegaly10.1INS, VIP
21hypogonadism10.1INS, TF
22hypercalcemia10.1SPINK1, ALB
23nutritional deficiency disease10.1TF, ALB
24alzheimer's disease10.1
25gingivitis10.1
26marasmus10.1ALB, TF
27protein-losing enteropathy10.1TF, ALB
28rhinitis10.1VIP, ALB
29acute erythroid leukemia10.1SPINK1, TF, VIP
30protein-energy malnutrition10.1ALB, TF
31primary hyperparathyroidism10.0
32hyperparathyroidism10.0
33lipoid nephrosis10.0TF, ALB
34alcoholic liver cirrhosis10.0ALB, TF
35fatty liver disease10.0TF, INS
36galactosemia10.0ALB, TF
37insulinoma10.0VIP, INS
38uremia10.0ALB, TF
39peripheral vascular disease10.0INS, ALB
40nephrotic syndrome10.0TF, ALB
41diabetic retinopathy10.0ALB, INS
42adenoma10.0SPINK1, INS, REG1A
43stroke, ischemic9.9ALB, INS
44cholera9.9VIP, INS, TF
45colonic benign neoplasm9.9SPINK1, VIP, REG1A
46hypersensitivity reaction type ii disease9.9ALB, INS
47primary hyperoxaluria9.9SPINK1, TF, ALB
48liver cirrhosis9.8ALB, VIP, TF
49essential hypertension9.8ALB, INS
50type 2 diabetes mellitus9.8SPINK1, INS, ALB

Graphical network of the top 20 diseases related to Fibrocalculous Pancreatic Diabetes:



Diseases related to fibrocalculous pancreatic diabetes

Symptoms for Fibrocalculous Pancreatic Diabetes

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Symptoms by clinical synopsis from OMIM:

608189

Clinical features from OMIM:

608189

HPO human phenotypes related to Fibrocalculous Pancreatic Diabetes:

(show all 8)
id Description Frequency HPO Source Accession
1 autosomal dominant inheritance HP:0000006
2 autosomal recessive inheritance HP:0000007
3 abdominal pain HP:0002027
4 neoplasm of the pancreas HP:0002894
5 pancreatic calcification HP:0005213
6 pancreatic calcification HP:0005213
7 chronic pancreatitis HP:0006280
8 insulin-dependent but ketosis-resistant diabetes HP:0008205

Drugs & Therapeutics for Fibrocalculous Pancreatic Diabetes

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Drug clinical trials:

Search ClinicalTrials for Fibrocalculous Pancreatic Diabetes

Search NIH Clinical Center for Fibrocalculous Pancreatic Diabetes

Genetic Tests for Fibrocalculous Pancreatic Diabetes

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Anatomical Context for Fibrocalculous Pancreatic Diabetes

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MalaCards organs/tissues related to Fibrocalculous Pancreatic Diabetes:

32
Pancreatic islet

Animal Models for Fibrocalculous Pancreatic Diabetes or affiliated genes

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MGI Mouse Phenotypes related to Fibrocalculous Pancreatic Diabetes:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107687.7ALB, VIP, INS, TF, SPINK1
2MP:00053797.6ALB, REG1A, VIP, INS, SPINK1
3MP:00053766.9SPINK1, TF, INS, VIP, REG1A, ALB

Publications for Fibrocalculous Pancreatic Diabetes

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Articles related to Fibrocalculous Pancreatic Diabetes:

(show all 49)
idTitleAuthorsYear
1
Fibrocalculous pancreatic diabetes (FCPD). (25395047)
2014
2
Cataract in children and adolescents with fibrocalculous pancreatic diabetes. (23715357)
2013
3
Prevalence of cardiac autonomic neuropathy in Asian Indian patients with fibrocalculous pancreatic diabetes. (23087858)
2012
4
Fibrocalculous pancreatic diabetes in a young Ugandan patient, a rare form of secondary diabetes. (23126518)
2012
5
Secular trends of fibrocalculous pancreatic diabetes and diabetes secondary to alcoholic chronic pancreatitis at a tertiary care diabetes centre in South India. (22406602)
2012
6
Fibrocalculous pancreatic diabetes in a Nigerian patient. (20587936)
2010
7
A clinical profile of fibrocalculous pancreatic diabetes patients from eastern India with special reference to body fat percentage and insulin resistance. (20469780)
2009
8
Tropical pancreatitis and fibrocalculous pancreatic diabetes--two sides of the same coin? (19115613)
2008
9
Prevalence of fibrocalculous pancreatic diabetes in Chennai in South India. (18648140)
2008
10
Fibrocalculous pancreatic diabetes in patient residing in the Mediterranean region. (16749187)
2006
11
A SPINK1 gene mutation in a Thai patient with fibrocalculous pancreatic diabetes. (17120980)
2006
12
The clinical spectrum of fibrocalculous pancreatic diabetes in north India. (12540065)
2002
13
SPINK1 is a susceptibility gene for fibrocalculous pancreatic diabetes in subjects from the Indian subcontinent. (12187509)
2002
14
Genetic susceptibility to fibrocalculous pancreatic diabetes in Bangladeshi subjects: a family study. (11857053)
2002
15
Histopathology and immunohistochemistry of pancreatic islets in fibrocalculous pancreatic diabetes. (11137179)
2001
16
Fibrocalculous pancreatic diabetes and macrovascular disease. (11868882)
2001
17
Copper, zinc and magnesium levels in fibrocalculous pancreatic diabetes. (11026752)
2000
18
Hemiplegia in a patient with fibrocalculous pancreatic diabetes. (11310401)
2000
19
Pancreatitis in fibrocalculous pancreatic diabetes mellitus is not associated with common mutations in the trypsinogen gene. (11114105)
2000
20
Fibrocalculous pancreatic diabetes in a child: case report. (10734545)
1999
21
Fibrocalculous pancreatic diabetes in a patient from Bihar. (10999178)
1999
22
Antibodies to pancreatic islet cell antigens in diabetes seen in Southern India with particular reference to fibrocalculous pancreatic diabetes. (9507918)
1998
23
Fibrocalculous pancreatic diabetes. (9679668)
1998
24
Ketosis resistance in fibrocalculous pancreatic diabetes: II. Hepatic ketogenesis after oral medium-chain triglycerides. (9005960)
1997
25
Analysis of islet regenerating (reg) gene polymorphisms in fibrocalculous pancreatic diabetes. (9057183)
1997
26
Fibrocalculous pancreatic diabetes. Long-term survival analysis. (8908394)
1996
27
A study of cell-mediated immune response to pancreatic antigens in patients with fibrocalculous pancreatic diabetes. (9177822)
1996
28
Autonomic dysfunction in non-insulin-dependent diabetes mellitus and fibrocalculous pancreatic diabetes in south India. (8973885)
1996
29
Fibrocalculous pancreatic diabetes in infancy--two case reports. (7821193)
1994
30
Macrovascular disease is not that uncommon in fibrocalculous pancreatic diabetes. (8062624)
1994
31
Cardiac autonomic function in fibrocalculous pancreatic diabetes. (8329729)
1993
32
Fibrocalculous pancreatic diabetes: clinical profile in Libya. (7688337)
1993
33
Are patients with fibrocalculous pancreatic diabetes a subset of chronic calcific pancreatitis of the tropics with genetic predisposition to type 1 (insulin-dependent) diabetes? (8243880)
1993
34
Fibrocalculous pancreatic diabetes in Pune, India. Clinical features and follow-up for 7 yr. (8325206)
1993
35
Presence of autoimmunity to pancreatic antigens in a patient with fibrocalculous pancreatic diabetes. (1446574)
1992
36
Fibrocalculous pancreatic diabetes in an elderly male. (1452545)
1992
37
Nutritional profile of fibrocalculous pancreatic diabetes and primary forms of diabetes seen in southern India. (2036942)
1991
38
Pregnancy in fibrocalculous pancreatic diabetes. (1960172)
1991
39
Plasma glucagon responses in tropical fibrocalculous pancreatic diabetes. (2190785)
1990
40
Pancreatic C-peptide response to oral glucose in fibrocalculous pancreatic diabetes. Improvement after treatment. (2190776)
1990
41
Fibrocalculous pancreatic diabetes and obesity. (2307093)
1990
42
Familial aggregation in tropical fibrocalculous pancreatic diabetes. (2813331)
1989
43
The genetic predisposition to fibrocalculous pancreatic diabetes. (2565269)
1989
44
Two case reports of macrovascular complications in fibrocalculous pancreatic diabetes. (2629452)
1989
45
Fibrocalculous pancreatic diabetes in the elderly. (2613640)
1989
46
Exocrine pancreatic function in tropical fibrocalculous pancreatic diabetes. (2467788)
1989
47
Fibrocalculous pancreatic diabetes in Papua New Guinea. (3407011)
1988
48
Case-control study on risk factors associated with fibrocalculous pancreatic diabetes. (2976643)
1988
49
Fibrocalculous pancreatic diabetes in Papua New Guinea. (3293881)
1988

Variations for Fibrocalculous Pancreatic Diabetes

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UniProtKB/Swiss-Prot genetic disease variations for Fibrocalculous Pancreatic Diabetes:

64
id Symbol AA change Variation ID SNP ID
1SPINK1p.Asn34SerVAR_011689rs17107315

Clinvar genetic disease variations for Fibrocalculous Pancreatic Diabetes:

6
id Gene Name Type Significance SNP ID Assembly Location
1SPINK1NM_003122.4(SPINK1): c.101A> G (p.Asn34Ser)single nucleotide variantPathogenicrs17107315GRCh37Chr 5, 147207678: 147207678
2SPINK1SPINK1, -215G-Tsingle nucleotide variantPathogenic

Expression for genes affiliated with Fibrocalculous Pancreatic Diabetes

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Expression patterns in normal tissues for genes affiliated with Fibrocalculous Pancreatic Diabetes

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Pathways for genes affiliated with Fibrocalculous Pancreatic Diabetes

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Compounds for genes affiliated with Fibrocalculous Pancreatic Diabetes

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Compounds related to Fibrocalculous Pancreatic Diabetes according to GeneCards/GeneDecks:

(show top 50)    (show all 57)
idCompoundScoreTop Affiliating Genes
1potassium chloride44 1110.9VIP, TF
2chromium picolinate449.8INS, TF
3leupeptin449.8VIP, TF
4starch449.7INS, TF
5trypsinogen449.6CTRC, REG1A, SPINK1
68-isoprostane449.6INS, TF
7glibenclamide44 28 50 6112.6VIP, INS
8kp-1019449.6TF, ALB
9bismuth44 2410.6ALB, TF
10gelfoam449.6TF, ALB
11nicotinamide44 1110.6REG1A, INS
12suprofen44 1110.5ALB, TF
13octreotide44 61 28 1112.5VIP, INS
14enalapril44 50 1111.5ALB, VIP
15antipyrine44 1110.5ALB, TF
16dtpa449.5ALB, TF
17nn304449.5INS, ALB
18captopril44 61 50 28 1113.5VIP, ALB
19fructosamine44 2410.4ALB, INS
20naloxone44 28 50 1112.4ALB, VIP
21repaglinide50 44 1111.4ALB, INS
22glutaraldehyde449.4TF, ALB
23ramipril44 1110.4INS, ALB
24gliclazide44 50 1111.4INS, ALB
25nateglinide44 50 1111.4INS, ALB
26telmisartan44 28 1111.4ALB, INS
27pge1449.4VIP, TF
28rosuvastatin44 50 28 1112.3INS, ALB
29ibmx44 61 2811.3TF, INS, VIP
30vitamin b12449.2ALB, TF
31epinephrine44 24 1111.2TF, INS, VIP
32norepinephrine44 24 1111.2TF, INS, VIP
33stearic acid44 24 1111.2VIP, ALB
34tetracycline44 1110.1ALB, TF
35bicarbonate449.1ALB, VIP, TF
36polyethylene glycol449.1ALB, VIP, TF
37prednisolone44 28 1111.1TF, VIP, ALB
38olanzapine44 50 28 24 1113.1ALB, INS
39histamine44 28 2411.0ALB, VIP, TF
40palmitate448.9ALB, INS, TF
41tacrolimus44 50 1110.9TF, INS, ALB
42aspartate448.9TF, VIP, ALB
43fibrinogen448.9ALB, INS, TF
44myristic acid44 24 1110.7ALB, INS
45creatinine448.6SPINK1, TF, INS, ALB
46thyroxine44 249.5ALB, VIP, INS, TF
47serine448.5SPINK1, INS, VIP, REG1A, CTRC
48lactate448.5TF, INS, VIP, ALB
49alanine448.4ALB, VIP, INS, TF
50calcium44 50 24 1111.2SPINK1, VIP, REG1A, ALB, CTRC

GO Terms for genes affiliated with Fibrocalculous Pancreatic Diabetes

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Cellular components related to Fibrocalculous Pancreatic Diabetes according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1blood microparticleGO:0725629.1ALB, TF
2secretory granule lumenGO:0347749.0INS, TF
3extracellular regionGO:0055767.1ALB, SPINK1, TF, INS, VIP, REG1A

Biological processes related to Fibrocalculous Pancreatic Diabetes according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of vasodilationGO:0459099.5VIP, INS
2regulation of protein localizationGO:0328809.3INS, VIP
3retina homeostasisGO:0018959.1ALB, TF
4platelet degranulationGO:0025769.1ALB, TF
5positive regulation of cell proliferationGO:0082848.6REG1A, VIP, INS

Molecular functions related to Fibrocalculous Pancreatic Diabetes according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:0051799.4VIP, INS

Products for genes affiliated with Fibrocalculous Pancreatic Diabetes

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  • Antibodies
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Sources for Fibrocalculous Pancreatic Diabetes

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet