TCP
MCID: FBR063
MIFTS: 34

Fibrocalculous Pancreatic Diabetes (TCP) malady

Gastrointestinal, Endocrine categories

Summaries for Fibrocalculous Pancreatic Diabetes

Sources:
47OMIM, 33MalaCards
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MalaCards: Fibrocalculous Pancreatic Diabetes, also known as tropical calcific chronic pancreatitis, is related to tropical calcific pancreatitis and autonomic neuropathy. An important gene associated with Fibrocalculous Pancreatic Diabetes is SPINK1 (serine peptidase inhibitor, Kazal type 1), and among its related pathways are Selected targets of C/EBPalpha and FOXA2 and FOXA3 transcription factor networks. The compounds norepinephrine and captopril have been mentioned in the context of this disorder. Affiliated tissues include pancreatic islet, and related mouse phenotype homeostasis/metabolism.

Description from OMIM:47 608189

Aliases & Classifications for Fibrocalculous Pancreatic Diabetes

Sources:
47OMIM, 61UMLS, 49Orphanet, 26ICD10 via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal, Endocrine


Characteristics (Orphanet epidemiological data):

49

Aliases & Descriptions:

fibrocalculous pancreatic diabetes 47 61
tropical calcific chronic pancreatitis 49
tropical calcific pancreatitis 61
tropical pancreatitis 49
tcp 49


External Ids:

OMIM47 608189
ICD10 via Orphanet26 K86.1

Related Diseases for Fibrocalculous Pancreatic Diabetes

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Fibrocalculous Pancreatic Diabetes via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 102)
idRelated DiseaseScoreTop Affiliating Genes
1tropical calcific pancreatitis31.4SPINK1
2autonomic neuropathy30.4ALB, INS
3adenocarcinoma30.2SPINK1, VIP, REG1A
4cystic fibrosis30.2INS, VIP, ALB, SPINK1
5alzheimer's disease30.0INS, REG1A
6pancreatitis, chronic10.4
7fibrocalculous pancreatopathy10.4
8alcoholic pancreatitis10.3
9autonomic dysfunction10.3
10insulin resistance10.3
11kwashiorkor10.2
12celiac disease10.2
13pancreatitis, idiopathic10.2
14bone fracture10.2
15primary hyperparathyroidism10.0
16brain disease10.0
17pituitary adenoma10.0VIP
18cluster headache10.0VIP
19chronic fatigue syndrome10.0VIP
20multiple endocrine neoplasia10.0VIP
21rheumatoid arthritis10.0VIP
22stomach cancer10.0SPINK1
23hyperparathyroidism10.0ALB
24ulcerative colitis10.0ALB
25psoriasis10.0VIP
26appendicitis10.0CTRC
27pituitary tumors10.0VIP
28glucagonoma10.0VIP
29acquired immunodeficiency syndrome10.0ALB
30hepatitis b10.0ALB
31allergic rhinitis10.0VIP
32pancreatic islet cell tumors10.0VIP
33peritonitis10.0ALB
34amyloidosis10.0ALB
35ischemia10.0VIP
36gastrinoma10.0VIP
37asthma10.0VIP
38hemochromatosis10.0TF
39hyperprolactinemia10.0VIP
40sickle cell disease10.0TF
41thalassemia10.0TF
42porphyria cutanea tarda10.0TF
43acute pancreatitis10.0SPINK1, REG1A
44iron deficiency anemia10.0TF
45glomerulonephritis10.0ALB
46colorectal cancer10.0REG1A, SPINK1
47hereditary pancreatitis10.0SPINK1, REG1A
48multiple sclerosis10.0ALB
49fatty liver disease10.0INS
50hypothyroidism10.0INS

Graphical network of the top 20 diseases related to Fibrocalculous Pancreatic Diabetes:



Diseases related to fibrocalculous pancreatic diabetes

Clinical Features for Fibrocalculous Pancreatic Diabetes

Sources:
47OMIM
See all sources

Clinical features from OMIM:

608189

Clinical synopsis from OMIM:

608189

Drugs & Therapeutics for Fibrocalculous Pancreatic Diabetes

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Fibrocalculous Pancreatic Diabetes

Drug clinical trials:

Search ClinicalTrials for Fibrocalculous Pancreatic Diabetes

Search NIH Clinical Center for Fibrocalculous Pancreatic Diabetes

Search CenterWatch for Fibrocalculous Pancreatic Diabetes

Genetic Tests for Fibrocalculous Pancreatic Diabetes

Anatomical Context for Fibrocalculous Pancreatic Diabetes

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Fibrocalculous Pancreatic Diabetes:

33
Pancreatic islet

Animal Models for Fibrocalculous Pancreatic Diabetes or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Fibrocalculous Pancreatic Diabetes:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053767.2ALB, SPINK1, INS, REG1A, TF, VIP

Publications for Fibrocalculous Pancreatic Diabetes

Sources:
51PubMed
See all sources

Articles related to Fibrocalculous Pancreatic Diabetes:

(show all 48)
idTitleAuthorsYear
1
Cataract in children and adolescents with fibrocalculous pancreatic diabetes. (23715357)
2013
2
Prevalence of cardiac autonomic neuropathy in Asian Indian patients with fibrocalculous pancreatic diabetes. (23087858)
2012
3
Fibrocalculous pancreatic diabetes in a young Ugandan patient, a rare form of secondary diabetes. (23126518)
2012
4
Secular trends of fibrocalculous pancreatic diabetes and diabetes secondary to alcoholic chronic pancreatitis at a tertiary care diabetes centre in South India. (22406602)
2012
5
Fibrocalculous pancreatic diabetes in a Nigerian patient. (20587936)
2010
6
A clinical profile of fibrocalculous pancreatic diabetes patients from eastern India with special reference to body fat percentage and insulin resistance. (20469780)
2009
7
Tropical pancreatitis and fibrocalculous pancreatic diabetes--two sides of the same coin? (19115613)
2008
8
Prevalence of fibrocalculous pancreatic diabetes in Chennai in South India. (18648140)
2008
9
Fibrocalculous pancreatic diabetes in patient residing in the Mediterranean region. (16749187)
2006
10
A SPINK1 gene mutation in a Thai patient with fibrocalculous pancreatic diabetes. (17120980)
2006
11
The clinical spectrum of fibrocalculous pancreatic diabetes in north India. (12540065)
2002
12
SPINK1 is a susceptibility gene for fibrocalculous pancreatic diabetes in subjects from the Indian subcontinent. (12187509)
2002
13
Genetic susceptibility to fibrocalculous pancreatic diabetes in Bangladeshi subjects: a family study. (11857053)
2002
14
Histopathology and immunohistochemistry of pancreatic islets in fibrocalculous pancreatic diabetes. (11137179)
2001
15
Fibrocalculous pancreatic diabetes and macrovascular disease. (11868882)
2001
16
Copper, zinc and magnesium levels in fibrocalculous pancreatic diabetes. (11026752)
2000
17
Hemiplegia in a patient with fibrocalculous pancreatic diabetes. (11310401)
2000
18
Pancreatitis in fibrocalculous pancreatic diabetes mellitus is not associated with common mutations in the trypsinogen gene. (11114105)
2000
19
Fibrocalculous pancreatic diabetes in a child: case report. (10734545)
1999
20
Fibrocalculous pancreatic diabetes in a patient from Bihar. (10999178)
1999
21
Antibodies to pancreatic islet cell antigens in diabetes seen in Southern India with particular reference to fibrocalculous pancreatic diabetes. (9507918)
1998
22
Fibrocalculous pancreatic diabetes. (9679668)
1998
23
Ketosis resistance in fibrocalculous pancreatic diabetes: II. Hepatic ketogenesis after oral medium-chain triglycerides. (9005960)
1997
24
Analysis of islet regenerating (reg) gene polymorphisms in fibrocalculous pancreatic diabetes. (9057183)
1997
25
Fibrocalculous pancreatic diabetes. Long-term survival analysis. (8908394)
1996
26
A study of cell-mediated immune response to pancreatic antigens in patients with fibrocalculous pancreatic diabetes. (9177822)
1996
27
Autonomic dysfunction in non-insulin-dependent diabetes mellitus and fibrocalculous pancreatic diabetes in south India. (8973885)
1996
28
Fibrocalculous pancreatic diabetes in infancy--two case reports. (7821193)
1994
29
Macrovascular disease is not that uncommon in fibrocalculous pancreatic diabetes. (8062624)
1994
30
Cardiac autonomic function in fibrocalculous pancreatic diabetes. (8329729)
1993
31
Fibrocalculous pancreatic diabetes: clinical profile in Libya. (7688337)
1993
32
Are patients with fibrocalculous pancreatic diabetes a subset of chronic calcific pancreatitis of the tropics with genetic predisposition to type 1 (insulin-dependent) diabetes? (8243880)
1993
33
Fibrocalculous pancreatic diabetes in Pune, India. Clinical features and follow-up for 7 yr. (8325206)
1993
34
Presence of autoimmunity to pancreatic antigens in a patient with fibrocalculous pancreatic diabetes. (1446574)
1992
35
Fibrocalculous pancreatic diabetes in an elderly male. (1452545)
1992
36
Nutritional profile of fibrocalculous pancreatic diabetes and primary forms of diabetes seen in southern India. (2036942)
1991
37
Pregnancy in fibrocalculous pancreatic diabetes. (1960172)
1991
38
Plasma glucagon responses in tropical fibrocalculous pancreatic diabetes. (2190785)
1990
39
Pancreatic C-peptide response to oral glucose in fibrocalculous pancreatic diabetes. Improvement after treatment. (2190776)
1990
40
Fibrocalculous pancreatic diabetes and obesity. (2307093)
1990
41
Familial aggregation in tropical fibrocalculous pancreatic diabetes. (2813331)
1989
42
The genetic predisposition to fibrocalculous pancreatic diabetes. (2565269)
1989
43
Two case reports of macrovascular complications in fibrocalculous pancreatic diabetes. (2629452)
1989
44
Fibrocalculous pancreatic diabetes in the elderly. (2613640)
1989
45
Exocrine pancreatic function in tropical fibrocalculous pancreatic diabetes. (2467788)
1989
46
Fibrocalculous pancreatic diabetes in Papua New Guinea. (3407011)
1988
47
Case-control study on risk factors associated with fibrocalculous pancreatic diabetes. (2976643)
1988
48
Fibrocalculous pancreatic diabetes in Papua New Guinea. (3293881)
1988

Genetic Variations for Fibrocalculous Pancreatic Diabetes

Sources:
63UniProtKB/Swiss-Prot
See all sources

Genetic disease variations for Fibrocalculous Pancreatic Diabetes:

63
id Symbol AA change Variation SNP ID
1SPINK1p.Asn34SerVAR_011689rs17107315

Expression for genes affiliated with Fibrocalculous Pancreatic Diabetes

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Fibrocalculous Pancreatic Diabetes

Search GEO for disease gene expression data for Fibrocalculous Pancreatic Diabetes.

Pathways for genes affiliated with Fibrocalculous Pancreatic Diabetes

Sources:
12EMD Millipore, 38NCBI BioSystems Database
See all sources

Pathways related to Fibrocalculous Pancreatic Diabetes according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.1ALB, TF
29.0ALB, INS
39.0ALB, INS

Compounds for genes affiliated with Fibrocalculous Pancreatic Diabetes

Sources:
45Novoseek, 11DrugBank, 24HMDB, 29IUPHAR, 50PharmGKB, 60Tocris Bioscience
See all sources

Compounds related to Fibrocalculous Pancreatic Diabetes according to GeneCards/GeneDecks:

(show all 44)
idCompoundScoreTop Affiliating Genes
1norepinephrine45 11 2412.2VIP
2captopril45 29 50 60 1114.1VIP
3bicarbonate459.9TF, VIP
4potassium chloride45 1110.9TF, VIP
5chromium picolinate459.8TF, INS
6palmitate459.7TF, INS
7leupeptin459.6TF, VIP
8starch459.6TF, INS
9trypsinogen459.6SPINK1, REG1A, CTRC
10serine459.6VIP, CTRC, SPINK1
11Bismuth Subsalicylate119.6TF, ALB
12kp-1019459.6TF, ALB
13bismuth45 2410.5ALB, TF
14gelfoam459.5ALB, TF
15suprofen45 1110.5ALB, TF
168-isoprostane459.5TF, INS
17enalapril45 50 1111.5ALB, VIP
18antipyrine45 1110.5TF, ALB
19nn304459.5INS, ALB
20dtpa459.5ALB, TF
21fructosamine45 2410.4ALB, INS
22repaglinide45 50 1111.4ALB, INS
23glibenclamide45 29 50 6012.4INS, VIP
24ramipril45 1110.4ALB, INS
25gliclazide45 50 1111.4ALB, INS
26nateglinide45 50 1111.4ALB, INS
27glutaraldehyde459.4TF, ALB
28telmisartan45 29 1111.4INS, ALB
29rosuvastatin45 50 29 1112.3INS, ALB
30ibmx45 29 6011.3VIP, TF, INS
31nicotinamide45 1110.2REG1A, INS
32naloxone45 50 29 1112.2ALB, VIP
33epinephrine45 11 2411.2INS, TF, VIP
34polyethylene glycol459.1ALB, TF, VIP
35prednisolone45 29 1111.1VIP, TF, ALB
36tacrolimus45 50 1110.9TF, INS, ALB
37histamine45 29 2410.9ALB, TF, VIP
38fibrinogen458.8ALB, INS, TF
39olanzapine50 45 29 11 2412.7ALB, INS
40creatinine458.5ALB, SPINK1, INS, TF
41thyroxine45 249.5VIP, TF, INS, ALB
42lactate458.5VIP, TF, INS, ALB
43alanine458.4VIP, TF, INS, ALB
44calcium45 50 11 2411.0VIP, CTRC, REG1A, SPINK1, ALB

GO Terms for genes affiliated with Fibrocalculous Pancreatic Diabetes

Sources:
16Gene Ontology
See all sources

Cellular components related to Fibrocalculous Pancreatic Diabetes according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granule lumenGO:0347749.3INS, TF
2extracellular regionGO:0055766.9ALB, SPINK1, INS, REG1A, TF, VIP

Biological processes related to Fibrocalculous Pancreatic Diabetes according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of vasodilationGO:0459099.3INS, VIP
2regulation of protein localizationGO:0328809.1INS, VIP
3positive regulation of cell proliferationGO:0082848.9INS, REG1A, VIP

Products for genes affiliated with Fibrocalculous Pancreatic Diabetes

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Fibrocalculous Pancreatic Diabetes

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet