TCP
MCID: FBR063
MIFTS: 35

Fibrocalculous Pancreatic Diabetes (TCP) malady

Gastrointestinal diseases, Endocrine diseases categories

Summaries for Fibrocalculous Pancreatic Diabetes

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46OMIM, 32MalaCards
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MalaCards: Fibrocalculous Pancreatic Diabetes, also known as tropical calcific chronic pancreatitis, is related to pancreatitis and tropical calcific pancreatitis. An important gene associated with Fibrocalculous Pancreatic Diabetes is SPINK1 (serine peptidase inhibitor, Kazal type 1), and among its related pathways are Selected targets of C/EBPalpha and FOXA2 and FOXA3 transcription factor networks. The compounds norepinephrine and captopril have been mentioned in the context of this disorder. Related mouse phenotype homeostasis/metabolism.

Description from OMIM:46 608189

Aliases & Classifications for Fibrocalculous Pancreatic Diabetes

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Sources:
46OMIM, 60UMLS, 48Orphanet, 26ICD10 via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases, Endocrine diseases


Characteristics (Orphanet epidemiological data):

48

Aliases & Descriptions:

fibrocalculous pancreatic diabetes 46 60
tropical calcific chronic pancreatitis 48
tropical calcific pancreatitis 60
tropical pancreatitis 48
tcp 48


External Ids:

OMIM46 608189
ICD10 via Orphanet26 K86.1

Related Diseases for Fibrocalculous Pancreatic Diabetes

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17GeneCards, 18GeneDecks
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Diseases related to Fibrocalculous Pancreatic Diabetes via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 106)
idRelated DiseaseScoreTop Affiliating Genes
1pancreatitis31.6INS, CTRC, ALB, REG1A, SPINK1
2tropical calcific pancreatitis30.6SPINK1
3diabetes mellitus30.5SPINK1, ALB, REG1A, TF, INS
4autonomic neuropathy30.3ALB, INS
5hepatitis30.3TF, ALB
6obesity30.3INS
7adenocarcinoma30.2SPINK1, VIP, REG1A
8cystic fibrosis30.2INS, VIP, ALB, SPINK1
9hyperparathyroidism30.0ALB
10alzheimer's disease29.9INS, REG1A
11fibrocalculous pancreatopathy10.4
12alcoholic pancreatitis10.2
13diabetic cataract10.2
14diabetic autonomic neuropathy10.2
15cataract10.2
16diabetic neuropathy10.2
17hemiplegia10.2
18neuropathy10.2
19kwashiorkor10.2
20celiac disease10.2
21pancreas adenocarcinoma10.2
22bone fracture10.1
23primary hyperparathyroidism10.0
24brain disease10.0
25gingivitis10.0
26pituitary adenoma10.0VIP
27cluster headache10.0VIP
28chronic fatigue syndrome10.0VIP
29multiple endocrine neoplasia10.0VIP
30rheumatoid arthritis10.0VIP
31stomach cancer10.0SPINK1
32ulcerative colitis10.0ALB
33psoriasis10.0VIP
34appendicitis10.0CTRC
35pituitary tumors10.0VIP
36glucagonoma10.0VIP
37acquired immunodeficiency syndrome10.0ALB
38hepatitis b10.0ALB
39allergic rhinitis10.0VIP
40pancreatic islet cell tumors10.0VIP
41peritonitis10.0ALB
42amyloidosis10.0ALB
43ischemia10.0VIP
44gastrinoma10.0VIP
45asthma10.0VIP
46hemochromatosis10.0TF
47hyperprolactinemia10.0VIP
48sickle cell disease10.0TF
49alpha thalassemia10.0TF
50porphyria cutanea tarda10.0TF

Graphical network of the top 20 diseases related to Fibrocalculous Pancreatic Diabetes:



Diseases related to fibrocalculous pancreatic diabetes

Clinical Features for Fibrocalculous Pancreatic Diabetes

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46OMIM
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Clinical features from OMIM:

608189

Clinical synopsis from OMIM:

608189

Drugs & Therapeutics for Fibrocalculous Pancreatic Diabetes

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Fibrocalculous Pancreatic Diabetes

Drug clinical trials:

Search ClinicalTrials for Fibrocalculous Pancreatic Diabetes

Search NIH Clinical Center for Fibrocalculous Pancreatic Diabetes

Search CenterWatch for Fibrocalculous Pancreatic Diabetes

Genetic Tests for Fibrocalculous Pancreatic Diabetes

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Anatomical Context for Fibrocalculous Pancreatic Diabetes

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Animal Models for Fibrocalculous Pancreatic Diabetes or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Fibrocalculous Pancreatic Diabetes:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053767.2ALB, SPINK1, INS, REG1A, TF, VIP

Publications for Fibrocalculous Pancreatic Diabetes

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Genetic Variations for Fibrocalculous Pancreatic Diabetes

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62UniProtKB/Swiss-Prot
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Genetic disease variations for Fibrocalculous Pancreatic Diabetes:

62
id Symbol AA change Variation ID SNP ID
1SPINK1p.Asn34SerVAR_011689rs17107315

Expression for genes affiliated with Fibrocalculous Pancreatic Diabetes

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Fibrocalculous Pancreatic Diabetes

Search GEO for disease gene expression data for Fibrocalculous Pancreatic Diabetes.

Pathways for genes affiliated with Fibrocalculous Pancreatic Diabetes

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Sources:
12EMD Millipore, 37NCBI BioSystems Database
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Pathways related to Fibrocalculous Pancreatic Diabetes according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.1ALB, TF
29.0ALB, INS
39.0ALB, INS

Compounds for genes affiliated with Fibrocalculous Pancreatic Diabetes

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Sources:
44Novoseek, 11DrugBank, 24HMDB, 28IUPHAR, 49PharmGKB, 59Tocris Bioscience
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Compounds related to Fibrocalculous Pancreatic Diabetes according to GeneCards/GeneDecks:

(show all 44)
idCompoundScoreTop Affiliating Genes
1norepinephrine44 11 2412.2VIP
2captopril44 28 49 59 1114.1VIP
3bicarbonate449.9TF, VIP
4potassium chloride44 1110.9TF, VIP
5chromium picolinate449.8TF, INS
6palmitate449.7TF, INS
7leupeptin449.6TF, VIP
8starch449.6TF, INS
9trypsinogen449.6SPINK1, REG1A, CTRC
10serine449.6VIP, CTRC, SPINK1
11Bismuth Subsalicylate119.6TF, ALB
12kp-1019449.6TF, ALB
13bismuth44 2410.5ALB, TF
14gelfoam449.5ALB, TF
15suprofen44 1110.5ALB, TF
168-isoprostane449.5TF, INS
17enalapril44 49 1111.5ALB, VIP
18antipyrine44 1110.5TF, ALB
19nn304449.5INS, ALB
20dtpa449.5ALB, TF
21fructosamine44 2410.4ALB, INS
22repaglinide44 49 1111.4ALB, INS
23glibenclamide44 28 49 5912.4INS, VIP
24ramipril44 1110.4ALB, INS
25gliclazide44 49 1111.4ALB, INS
26nateglinide44 49 1111.4ALB, INS
27glutaraldehyde449.4TF, ALB
28telmisartan44 28 1111.4INS, ALB
29rosuvastatin44 49 28 1112.3INS, ALB
30ibmx44 28 5911.3VIP, TF, INS
31nicotinamide44 1110.2REG1A, INS
32naloxone44 49 28 1112.2ALB, VIP
33epinephrine44 11 2411.2INS, TF, VIP
34polyethylene glycol449.1ALB, TF, VIP
35prednisolone44 28 1111.1VIP, TF, ALB
36tacrolimus44 49 1110.9TF, INS, ALB
37histamine44 28 2410.9ALB, TF, VIP
38fibrinogen448.8ALB, INS, TF
39olanzapine49 44 28 11 2412.7ALB, INS
40creatinine448.5ALB, SPINK1, INS, TF
41thyroxine44 249.5VIP, TF, INS, ALB
42lactate448.5VIP, TF, INS, ALB
43alanine448.4VIP, TF, INS, ALB
44calcium44 49 11 2411.0VIP, CTRC, REG1A, SPINK1, ALB

GO Terms for genes affiliated with Fibrocalculous Pancreatic Diabetes

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16Gene Ontology
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Cellular components related to Fibrocalculous Pancreatic Diabetes according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granule lumenGO:0347749.3INS, TF
2extracellular regionGO:0055766.9ALB, SPINK1, INS, REG1A, TF, VIP

Biological processes related to Fibrocalculous Pancreatic Diabetes according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of vasodilationGO:0459099.3INS, VIP
2regulation of protein localizationGO:0328809.1INS, VIP
3positive regulation of cell proliferationGO:0082848.9INS, REG1A, VIP

Products for genes affiliated with Fibrocalculous Pancreatic Diabetes

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  • Antibodies
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Sources for Fibrocalculous Pancreatic Diabetes

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet