TCP
MCID: FBR063
MIFTS: 45

Fibrocalculous Pancreatic Diabetes (TCP) malady

Genetic diseases, Gastrointestinal diseases, Rare diseases, Endocrine diseases categories

Summaries for Fibrocalculous Pancreatic Diabetes

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48OMIM, 34MalaCards
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MalaCards: Fibrocalculous Pancreatic Diabetes, also known as tropical calcific chronic pancreatitis, is related to pancreatitis and diabetes mellitus. An important gene associated with Fibrocalculous Pancreatic Diabetes is SPINK1 (serine peptidase inhibitor, Kazal type 1), and among its related pathways are HIF-1 signaling pathway and Insulin receptor recycling. The compounds potassium chloride and chromium picolinate have been mentioned in the context of this disorder. Affiliated tissues include pancreatic islet, and related mouse phenotypes are mortality/aging and endocrine/exocrine gland.

Description from OMIM:48 608189

Aliases & Classifications for Fibrocalculous Pancreatic Diabetes

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48OMIM, 63UMLS, 50Orphanet, 27ICD10 via Orphanet
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Classifications:



Characteristics (Orphanet epidemiological data):

50

Aliases & Descriptions:

fibrocalculous pancreatic diabetes 48 63
tropical calcific chronic pancreatitis 50
tropical calcific pancreatitis 63
tropical pancreatitis 50
tcp 50


External Ids:

OMIM48 608189
ICD10 via Orphanet27 K86.1

Related Diseases for Fibrocalculous Pancreatic Diabetes

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18GeneCards, 19GeneDecks
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Diseases related to Fibrocalculous Pancreatic Diabetes via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 58)
idRelated DiseaseScoreTop Affiliating Genes
1pancreatitis31.5CTRC, ALB, REG1A, INS, SPINK1
2diabetes mellitus30.5SPINK1, TF, INS, REG1A, ALB
3hepatitis30.4TF, ALB
4autonomic neuropathy30.4ALB, INS
5neuropathy30.3ALB, INS
6fibrocalculous pancreatopathy10.4
7cataract10.3
8hemiplegia10.3
9obesity10.3
10autonomic dysfunction10.3
11insulin resistance10.3
12bone fracture10.2
13tropical calcific pancreatitis10.1SPINK1
14hereditary pancreatitis10.1REG1A, SPINK1
15pancreas disease10.1REG1A, SPINK1
16acute pancreatitis10.1SPINK1, REG1A
17pancreatitis, chronic10.1SPINK1, REG1A
18alzheimer's disease10.0
19gingivitis10.0
20primary hyperparathyroidism10.0
21hyperparathyroidism10.0
22pancreatic cancer10.0VIP, SPINK1
23hypokalemia10.0INS, VIP
24acromegaly10.0INS, VIP
25hypogonadism10.0INS, TF
26hypercalcemia10.0SPINK1, ALB
27nutritional deficiency disease10.0TF, ALB
28marasmus10.0ALB, TF
29protein-losing enteropathy10.0TF, ALB
30rhinitis10.0VIP, ALB
31acute erythroid leukemia10.0SPINK1, TF, VIP
32protein-energy malnutrition10.0ALB, TF
33lipoid nephrosis10.0TF, ALB
34alcoholic liver cirrhosis10.0ALB, TF
35fatty liver disease10.0TF, INS
36galactosemia10.0ALB, TF
37insulinoma10.0VIP, INS
38uremia10.0ALB, TF
39peripheral vascular disease10.0INS, ALB
40nephrotic syndrome10.0TF, ALB
41diabetic retinopathy10.0ALB, INS
42adenoma10.0SPINK1, INS, REG1A
43stroke, ischemic10.0ALB, INS
44cholera10.0VIP, INS, TF
45colon cancer10.0SPINK1, VIP, REG1A
46hypersensitivity reaction type ii disease10.0ALB, INS
47primary hyperoxaluria10.0SPINK1, TF, ALB
48liver cirrhosis10.0ALB, VIP, TF
49essential hypertension10.0ALB, INS
50type 2 diabetes mellitus10.0SPINK1, INS, ALB

Graphical network of the top 20 diseases related to Fibrocalculous Pancreatic Diabetes:



Diseases related to fibrocalculous pancreatic diabetes

Symptoms for Fibrocalculous Pancreatic Diabetes

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48OMIM
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Symptoms by clinical synopsis from OMIM:

608189

Clinical features from OMIM:

608189

Drugs & Therapeutics for Fibrocalculous Pancreatic Diabetes

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Fibrocalculous Pancreatic Diabetes

Drug clinical trials:

Search ClinicalTrials for Fibrocalculous Pancreatic Diabetes

Search NIH Clinical Center for Fibrocalculous Pancreatic Diabetes

Search CenterWatch for Fibrocalculous Pancreatic Diabetes

Genetic Tests for Fibrocalculous Pancreatic Diabetes

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Anatomical Context for Fibrocalculous Pancreatic Diabetes

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34MalaCards
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MalaCards organs/tissues related to Fibrocalculous Pancreatic Diabetes:

34
Pancreatic islet

Animal Models for Fibrocalculous Pancreatic Diabetes or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Fibrocalculous Pancreatic Diabetes:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107687.7ALB, VIP, INS, TF, SPINK1
2MP:00053797.6ALB, REG1A, VIP, INS, SPINK1
3MP:00053766.9SPINK1, TF, INS, VIP, REG1A, ALB

Publications for Fibrocalculous Pancreatic Diabetes

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53PubMed
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Articles related to Fibrocalculous Pancreatic Diabetes:

(show all 47)
idTitleAuthorsYear
1
Cataract in children and adolescents with fibrocalculous pancreatic diabetes. (23715357)
2013
2
Prevalence of cardiac autonomic neuropathy in Asian Indian patients with fibrocalculous pancreatic diabetes. (23087858)
2012
3
Fibrocalculous pancreatic diabetes in a young Ugandan patient, a rare form of secondary diabetes. (23126518)
2012
4
Secular trends of fibrocalculous pancreatic diabetes and diabetes secondary to alcoholic chronic pancreatitis at a tertiary care diabetes centre in South India. (22406602)
2012
5
Fibrocalculous pancreatic diabetes in a Nigerian patient. (20587936)
2010
6
A clinical profile of fibrocalculous pancreatic diabetes patients from eastern India with special reference to body fat percentage and insulin resistance. (20469780)
2009
7
Tropical pancreatitis and fibrocalculous pancreatic diabetes--two sides of the same coin? (19115613)
2008
8
Prevalence of fibrocalculous pancreatic diabetes in Chennai in South India. (18648140)
2008
9
Fibrocalculous pancreatic diabetes in patient residing in the Mediterranean region. (16749187)
2006
10
A SPINK1 gene mutation in a Thai patient with fibrocalculous pancreatic diabetes. (17120980)
2006
11
The clinical spectrum of fibrocalculous pancreatic diabetes in north India. (12540065)
2002
12
SPINK1 is a susceptibility gene for fibrocalculous pancreatic diabetes in subjects from the Indian subcontinent. (12187509)
2002
13
Genetic susceptibility to fibrocalculous pancreatic diabetes in Bangladeshi subjects: a family study. (11857053)
2002
14
Histopathology and immunohistochemistry of pancreatic islets in fibrocalculous pancreatic diabetes. (11137179)
2001
15
Fibrocalculous pancreatic diabetes and macrovascular disease. (11868882)
2001
16
Copper, zinc and magnesium levels in fibrocalculous pancreatic diabetes. (11026752)
2000
17
Hemiplegia in a patient with fibrocalculous pancreatic diabetes. (11310401)
2000
18
Pancreatitis in fibrocalculous pancreatic diabetes mellitus is not associated with common mutations in the trypsinogen gene. (11114105)
2000
19
Fibrocalculous pancreatic diabetes in a child: case report. (10734545)
1999
20
Fibrocalculous pancreatic diabetes in a patient from Bihar. (10999178)
1999
21
Antibodies to pancreatic islet cell antigens in diabetes seen in Southern India with particular reference to fibrocalculous pancreatic diabetes. (9507918)
1998
22
Fibrocalculous pancreatic diabetes. (9679668)
1998
23
Ketosis resistance in fibrocalculous pancreatic diabetes: II. Hepatic ketogenesis after oral medium-chain triglycerides. (9005960)
1997
24
Analysis of islet regenerating (reg) gene polymorphisms in fibrocalculous pancreatic diabetes. (9057183)
1997
25
Fibrocalculous pancreatic diabetes. Long-term survival analysis. (8908394)
1996
26
A study of cell-mediated immune response to pancreatic antigens in patients with fibrocalculous pancreatic diabetes. (9177822)
1996
27
Autonomic dysfunction in non-insulin-dependent diabetes mellitus and fibrocalculous pancreatic diabetes in south India. (8973885)
1996
28
Fibrocalculous pancreatic diabetes in infancy--two case reports. (7821193)
1994
29
Macrovascular disease is not that uncommon in fibrocalculous pancreatic diabetes. (8062624)
1994
30
Cardiac autonomic function in fibrocalculous pancreatic diabetes. (8329729)
1993
31
Fibrocalculous pancreatic diabetes: clinical profile in Libya. (7688337)
1993
32
Are patients with fibrocalculous pancreatic diabetes a subset of chronic calcific pancreatitis of the tropics with genetic predisposition to type 1 (insulin-dependent) diabetes? (8243880)
1993
33
Fibrocalculous pancreatic diabetes in Pune, India. Clinical features and follow-up for 7 yr. (8325206)
1993
34
Presence of autoimmunity to pancreatic antigens in a patient with fibrocalculous pancreatic diabetes. (1446574)
1992
35
Fibrocalculous pancreatic diabetes in an elderly male. (1452545)
1992
36
Nutritional profile of fibrocalculous pancreatic diabetes and primary forms of diabetes seen in southern India. (2036942)
1991
37
Pregnancy in fibrocalculous pancreatic diabetes. (1960172)
1991
38
Plasma glucagon responses in tropical fibrocalculous pancreatic diabetes. (2190785)
1990
39
Pancreatic C-peptide response to oral glucose in fibrocalculous pancreatic diabetes. Improvement after treatment. (2190776)
1990
40
Fibrocalculous pancreatic diabetes and obesity. (2307093)
1990
41
Familial aggregation in tropical fibrocalculous pancreatic diabetes. (2813331)
1989
42
The genetic predisposition to fibrocalculous pancreatic diabetes. (2565269)
1989
43
Two case reports of macrovascular complications in fibrocalculous pancreatic diabetes. (2629452)
1989
44
Fibrocalculous pancreatic diabetes in the elderly. (2613640)
1989
45
Fibrocalculous pancreatic diabetes in Papua New Guinea. (3407011)
1988
46
Case-control study on risk factors associated with fibrocalculous pancreatic diabetes. (2976643)
1988
47
Fibrocalculous pancreatic diabetes in Papua New Guinea. (3293881)
1988

Variations for Fibrocalculous Pancreatic Diabetes

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65UniProtKB/Swiss-Prot, 1 National Center for Biotechnology Information (Clinvar), 8dbSNP
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UniProtKB/Swiss-Prot genetic disease variations for Fibrocalculous Pancreatic Diabetes:

65
id Symbol AA change Variation ID SNP ID
1SPINK1p.Asn34SerVAR_011689rs17107315

Clinvar genetic disease variations for Fibrocalculous Pancreatic Diabetes:

1
id Gene Name Type Significance SNP ID Assembly Location
1SPINK1NM_003122.4(SPINK1): c.101A> G (p.Asn34Ser)single nucleotide variantPathogenic, risk factorrs17107315GRCh37Chr 5, 147207678: 147207678
2SPINK1SPINK1, -215G-Tsingle nucleotide variantPathogenic

Expression for genes affiliated with Fibrocalculous Pancreatic Diabetes

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Fibrocalculous Pancreatic Diabetes

Search GEO for disease gene expression data for Fibrocalculous Pancreatic Diabetes.

Pathways for genes affiliated with Fibrocalculous Pancreatic Diabetes

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51PathCards, 31KEGG, 56Reactome, 13EMD Millipore, 39NCBI BioSystems Database
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Compounds for genes affiliated with Fibrocalculous Pancreatic Diabetes

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46Novoseek, 12DrugBank, 30IUPHAR, 52PharmGKB, 62Tocris Bioscience, 25HMDB
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Compounds related to Fibrocalculous Pancreatic Diabetes according to GeneCards/GeneDecks:

(show top 50)    (show all 57)
idCompoundScoreTop Affiliating Genes
1potassium chloride46 1210.9VIP, TF
2chromium picolinate469.8INS, TF
3leupeptin469.8VIP, TF
4starch469.7INS, TF
5trypsinogen469.6CTRC, REG1A, SPINK1
68-isoprostane469.6INS, TF
7glibenclamide46 30 52 6212.6VIP, INS
8kp-1019469.6TF, ALB
9bismuth46 2510.6ALB, TF
10gelfoam469.6TF, ALB
11nicotinamide46 1210.6REG1A, INS
12suprofen46 1210.5ALB, TF
13octreotide46 62 30 1212.5VIP, INS
14enalapril46 52 1211.5ALB, VIP
15antipyrine46 1210.5ALB, TF
16dtpa469.5ALB, TF
17nn304469.5INS, ALB
18captopril46 62 52 30 1213.5VIP, ALB
19fructosamine46 2510.4ALB, INS
20naloxone46 30 52 1212.4ALB, VIP
21repaglinide52 46 1211.4ALB, INS
22glutaraldehyde469.4TF, ALB
23ramipril46 1210.4INS, ALB
24gliclazide46 52 1211.4INS, ALB
25nateglinide46 52 1211.4INS, ALB
26telmisartan46 30 1211.4ALB, INS
27pge1469.4VIP, TF
28rosuvastatin46 52 30 1212.3INS, ALB
29ibmx46 62 3011.3TF, INS, VIP
30vitamin b12469.2ALB, TF
31epinephrine46 25 1211.2TF, INS, VIP
32norepinephrine46 25 1211.2TF, INS, VIP
33stearic acid46 25 1211.2VIP, ALB
34tetracycline46 1210.1ALB, TF
35bicarbonate469.1ALB, VIP, TF
36polyethylene glycol469.1ALB, VIP, TF
37prednisolone46 30 1211.1TF, VIP, ALB
38olanzapine46 52 30 25 1213.1ALB, INS
39histamine46 30 2511.0ALB, VIP, TF
40palmitate468.9ALB, INS, TF
41tacrolimus46 52 1210.9TF, INS, ALB
42aspartate468.9TF, VIP, ALB
43fibrinogen468.9ALB, INS, TF
44myristic acid46 25 1210.7ALB, INS
45creatinine468.6SPINK1, TF, INS, ALB
46thyroxine46 259.5ALB, VIP, INS, TF
47serine468.5SPINK1, INS, VIP, REG1A, CTRC
48lactate468.5TF, INS, VIP, ALB
49alanine468.4ALB, VIP, INS, TF
50calcium46 52 25 1211.2SPINK1, VIP, REG1A, ALB, CTRC

GO Terms for genes affiliated with Fibrocalculous Pancreatic Diabetes

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17Gene Ontology
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Cellular components related to Fibrocalculous Pancreatic Diabetes according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1blood microparticleGO:0725629.1ALB, TF
2secretory granule lumenGO:0347749.0INS, TF
3extracellular regionGO:0055767.1ALB, SPINK1, TF, INS, VIP, REG1A

Biological processes related to Fibrocalculous Pancreatic Diabetes according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of vasodilationGO:0459099.5VIP, INS
2regulation of protein localizationGO:0328809.3INS, VIP
3retina homeostasisGO:0018959.1ALB, TF
4platelet degranulationGO:0025769.1ALB, TF
5positive regulation of cell proliferationGO:0082848.6REG1A, VIP, INS

Molecular functions related to Fibrocalculous Pancreatic Diabetes according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:0051799.4VIP, INS

Products for genes affiliated with Fibrocalculous Pancreatic Diabetes

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Sources for Fibrocalculous Pancreatic Diabetes

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet