TCP
MCID: FBR063
MIFTS: 46

Fibrocalculous Pancreatic Diabetes (TCP) malady

Genetic diseases, Gastrointestinal diseases, Rare diseases, Endocrine diseases categories

Summaries for Fibrocalculous Pancreatic Diabetes

About this section


MalaCards based summary: Fibrocalculous Pancreatic Diabetes, also known as TCP, is related to pancreatitis and hepatitis, and has symptoms including autosomal dominant inheritance, autosomal recessive inheritance and abdominal pain. An important gene associated with Fibrocalculous Pancreatic Diabetes is SPINK1 (serine peptidase inhibitor, Kazal type 1), and among its related pathways are HIF-1 signaling pathway and Insulin receptor recycling. The compounds potassium chloride and chromium picolinate have been mentioned in the context of this disorder. Affiliated tissues include pancreatic islet, and related mouse phenotypes are mortality/aging and endocrine/exocrine gland.

Description from OMIM:46 608189

Aliases & Classifications for Fibrocalculous Pancreatic Diabetes

About this section
Sources:
46OMIM, 61UMLS, 48Orphanet, 27ICD10 via Orphanet
See all sources

Fibrocalculous Pancreatic Diabetes, Aliases & Descriptions:

Name: Fibrocalculous Pancreatic Diabetes 46 61
Tcp 48 61
 
Tropical Calcific Chronic Pancreatitis 48
Tropical Pancreatitis 48


Classifications:



Characteristics (Orphanet epidemiological data):

48
tcp:
Age of onset: Childhood


External Ids:

OMIM46 608189
ICD10 via Orphanet27 K86.1

Related Diseases for Fibrocalculous Pancreatic Diabetes

About this section

Diseases related to Fibrocalculous Pancreatic Diabetes via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 58)
idRelated DiseaseScoreTop Affiliating Genes
1pancreatitis30.9INS, REG1A, ALB, CTRC, SPINK1
2hepatitis30.5ALB, TF
3autonomic neuropathy30.4ALB, INS
4neuropathy30.1INS, ALB
5diabetes mellitus29.9SPINK1, TF, INS, REG1A, ALB
6tropical calcific pancreatitis10.5SPINK1
7fibrocalculous pancreatopathy10.4
8hereditary pancreatitis10.3REG1A, SPINK1
9cataract10.3
10obesity10.3
11hemiplegia10.3
12autonomic dysfunction10.3
13insulin resistance10.3
14pancreas disease10.3SPINK1, REG1A
15acute pancreatitis10.2REG1A, SPINK1
16pancreatitis, chronic10.2SPINK1, REG1A
17bone fracture10.2
18pancreatic cancer10.2VIP, SPINK1
19hypokalemia10.1VIP, INS
20acromegaly10.1VIP, INS
21hypogonadism10.1INS, TF
22hypercalcemia10.1SPINK1, ALB
23nutritional deficiency disease10.1TF, ALB
24marasmus10.1ALB, TF
25alzheimer's disease10.1
26gingivitis10.1
27protein-losing enteropathy10.1ALB, TF
28rhinitis10.1ALB, VIP
29acute erythroid leukemia10.1TF, SPINK1, VIP
30protein-energy malnutrition10.1ALB, TF
31primary hyperparathyroidism10.0
32hyperparathyroidism10.0
33lipoid nephrosis10.0ALB, TF
34alcoholic liver cirrhosis10.0TF, ALB
35fatty liver disease10.0INS, TF
36galactosemia10.0ALB, TF
37insulinoma10.0INS, VIP
38uremia10.0TF, ALB
39peripheral vascular disease10.0INS, ALB
40nephrotic syndrome10.0ALB, TF
41diabetic retinopathy10.0ALB, INS
42adenoma10.0INS, SPINK1, REG1A
43stroke, ischemic9.9INS, ALB
44cholera9.9TF, VIP, INS
45colonic benign neoplasm9.9REG1A, VIP, SPINK1
46hypersensitivity reaction type ii disease9.9ALB, INS
47primary hyperoxaluria9.9TF, SPINK1, ALB
48liver cirrhosis9.9TF, VIP, ALB
49essential hypertension9.8INS, ALB
50type 2 diabetes mellitus9.8ALB, INS, SPINK1

Graphical network of the top 20 diseases related to Fibrocalculous Pancreatic Diabetes:



Diseases related to fibrocalculous pancreatic diabetes

Symptoms for Fibrocalculous Pancreatic Diabetes

About this section

Symptoms by clinical synopsis from OMIM:

608189

Clinical features from OMIM:

608189

HPO human phenotypes related to Fibrocalculous Pancreatic Diabetes:

(show all 8)
id Description Frequency HPO Source Accession
1 autosomal dominant inheritance HP:0000006
2 autosomal recessive inheritance HP:0000007
3 abdominal pain HP:0002027
4 neoplasm of the pancreas HP:0002894
5 pancreatic calcification HP:0005213
6 pancreatic calcification HP:0005213
7 chronic pancreatitis HP:0006280
8 insulin-dependent but ketosis-resistant diabetes HP:0008205

Drugs & Therapeutics for Fibrocalculous Pancreatic Diabetes

About this section

Drug clinical trials:

Search ClinicalTrials for Fibrocalculous Pancreatic Diabetes

Search NIH Clinical Center for Fibrocalculous Pancreatic Diabetes

Genetic Tests for Fibrocalculous Pancreatic Diabetes

About this section

Anatomical Context for Fibrocalculous Pancreatic Diabetes

About this section

MalaCards organs/tissues related to Fibrocalculous Pancreatic Diabetes:

32
Pancreatic islet

Animal Models for Fibrocalculous Pancreatic Diabetes or affiliated genes

About this section

MGI Mouse Phenotypes related to Fibrocalculous Pancreatic Diabetes:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107687.7ALB, VIP, INS, TF, SPINK1
2MP:00053797.6ALB, REG1A, VIP, INS, SPINK1
3MP:00053766.9SPINK1, TF, INS, VIP, REG1A, ALB

Publications for Fibrocalculous Pancreatic Diabetes

About this section

Articles related to Fibrocalculous Pancreatic Diabetes:

(show all 49)
idTitleAuthorsYear
1
Fibrocalculous pancreatic diabetes (FCPD). (25395047)
2014
2
Cataract in children and adolescents with fibrocalculous pancreatic diabetes. (23715357)
2013
3
Prevalence of cardiac autonomic neuropathy in Asian Indian patients with fibrocalculous pancreatic diabetes. (23087858)
2012
4
Fibrocalculous pancreatic diabetes in a young Ugandan patient, a rare form of secondary diabetes. (23126518)
2012
5
Secular trends of fibrocalculous pancreatic diabetes and diabetes secondary to alcoholic chronic pancreatitis at a tertiary care diabetes centre in South India. (22406602)
2012
6
Fibrocalculous pancreatic diabetes in a Nigerian patient. (20587936)
2010
7
A clinical profile of fibrocalculous pancreatic diabetes patients from eastern India with special reference to body fat percentage and insulin resistance. (20469780)
2009
8
Tropical pancreatitis and fibrocalculous pancreatic diabetes--two sides of the same coin? (19115613)
2008
9
Prevalence of fibrocalculous pancreatic diabetes in Chennai in South India. (18648140)
2008
10
Fibrocalculous pancreatic diabetes in patient residing in the Mediterranean region. (16749187)
2006
11
A SPINK1 gene mutation in a Thai patient with fibrocalculous pancreatic diabetes. (17120980)
2006
12
The clinical spectrum of fibrocalculous pancreatic diabetes in north India. (12540065)
2002
13
SPINK1 is a susceptibility gene for fibrocalculous pancreatic diabetes in subjects from the Indian subcontinent. (12187509)
2002
14
Genetic susceptibility to fibrocalculous pancreatic diabetes in Bangladeshi subjects: a family study. (11857053)
2002
15
Histopathology and immunohistochemistry of pancreatic islets in fibrocalculous pancreatic diabetes. (11137179)
2001
16
Fibrocalculous pancreatic diabetes and macrovascular disease. (11868882)
2001
17
Copper, zinc and magnesium levels in fibrocalculous pancreatic diabetes. (11026752)
2000
18
Hemiplegia in a patient with fibrocalculous pancreatic diabetes. (11310401)
2000
19
Pancreatitis in fibrocalculous pancreatic diabetes mellitus is not associated with common mutations in the trypsinogen gene. (11114105)
2000
20
Fibrocalculous pancreatic diabetes in a child: case report. (10734545)
1999
21
Fibrocalculous pancreatic diabetes in a patient from Bihar. (10999178)
1999
22
Antibodies to pancreatic islet cell antigens in diabetes seen in Southern India with particular reference to fibrocalculous pancreatic diabetes. (9507918)
1998
23
Fibrocalculous pancreatic diabetes. (9679668)
1998
24
Ketosis resistance in fibrocalculous pancreatic diabetes: II. Hepatic ketogenesis after oral medium-chain triglycerides. (9005960)
1997
25
Analysis of islet regenerating (reg) gene polymorphisms in fibrocalculous pancreatic diabetes. (9057183)
1997
26
Fibrocalculous pancreatic diabetes. Long-term survival analysis. (8908394)
1996
27
A study of cell-mediated immune response to pancreatic antigens in patients with fibrocalculous pancreatic diabetes. (9177822)
1996
28
Autonomic dysfunction in non-insulin-dependent diabetes mellitus and fibrocalculous pancreatic diabetes in south India. (8973885)
1996
29
Fibrocalculous pancreatic diabetes in infancy--two case reports. (7821193)
1994
30
Macrovascular disease is not that uncommon in fibrocalculous pancreatic diabetes. (8062624)
1994
31
Cardiac autonomic function in fibrocalculous pancreatic diabetes. (8329729)
1993
32
Fibrocalculous pancreatic diabetes: clinical profile in Libya. (7688337)
1993
33
Are patients with fibrocalculous pancreatic diabetes a subset of chronic calcific pancreatitis of the tropics with genetic predisposition to type 1 (insulin-dependent) diabetes? (8243880)
1993
34
Fibrocalculous pancreatic diabetes in Pune, India. Clinical features and follow-up for 7 yr. (8325206)
1993
35
Presence of autoimmunity to pancreatic antigens in a patient with fibrocalculous pancreatic diabetes. (1446574)
1992
36
Fibrocalculous pancreatic diabetes in an elderly male. (1452545)
1992
37
Nutritional profile of fibrocalculous pancreatic diabetes and primary forms of diabetes seen in southern India. (2036942)
1991
38
Pregnancy in fibrocalculous pancreatic diabetes. (1960172)
1991
39
Plasma glucagon responses in tropical fibrocalculous pancreatic diabetes. (2190785)
1990
40
Pancreatic C-peptide response to oral glucose in fibrocalculous pancreatic diabetes. Improvement after treatment. (2190776)
1990
41
Fibrocalculous pancreatic diabetes and obesity. (2307093)
1990
42
Familial aggregation in tropical fibrocalculous pancreatic diabetes. (2813331)
1989
43
The genetic predisposition to fibrocalculous pancreatic diabetes. (2565269)
1989
44
Two case reports of macrovascular complications in fibrocalculous pancreatic diabetes. (2629452)
1989
45
Fibrocalculous pancreatic diabetes in the elderly. (2613640)
1989
46
Exocrine pancreatic function in tropical fibrocalculous pancreatic diabetes. (2467788)
1989
47
Fibrocalculous pancreatic diabetes in Papua New Guinea. (3407011)
1988
48
Case-control study on risk factors associated with fibrocalculous pancreatic diabetes. (2976643)
1988
49
Fibrocalculous pancreatic diabetes in Papua New Guinea. (3293881)
1988

Variations for Fibrocalculous Pancreatic Diabetes

About this section

UniProtKB/Swiss-Prot genetic disease variations for Fibrocalculous Pancreatic Diabetes:

63
id Symbol AA change Variation ID SNP ID
1SPINK1p.Asn34SerVAR_011689rs17107315

Clinvar genetic disease variations for Fibrocalculous Pancreatic Diabetes:

7
id Gene Name Type Significance SNP ID Assembly Location
1SPINK1NM_003122.4(SPINK1): c.101A> G (p.Asn34Ser)single nucleotide variantPathogenic, risk factorrs17107315GRCh37Chr 5, 147207678: 147207678
2SPINK1SPINK1, -215G-Tsingle nucleotide variantPathogenic

Expression for genes affiliated with Fibrocalculous Pancreatic Diabetes

About this section
Expression patterns in normal tissues for genes affiliated with Fibrocalculous Pancreatic Diabetes

Search GEO for disease gene expression data for Fibrocalculous Pancreatic Diabetes.

Pathways for genes affiliated with Fibrocalculous Pancreatic Diabetes

About this section

Compounds for genes affiliated with Fibrocalculous Pancreatic Diabetes

About this section

Compounds related to Fibrocalculous Pancreatic Diabetes according to GeneCards/GeneDecks:

(show top 50)    (show all 57)
idCompoundScoreTop Affiliating Genes
1potassium chloride44 1210.9VIP, TF
2chromium picolinate449.8INS, TF
3leupeptin449.8VIP, TF
4starch449.7INS, TF
5trypsinogen449.6CTRC, REG1A, SPINK1
68-isoprostane449.6INS, TF
7glibenclamide44 29 50 6012.6VIP, INS
8kp-1019449.6TF, ALB
9bismuth44 2510.6ALB, TF
10gelfoam449.6TF, ALB
11nicotinamide44 1210.6REG1A, INS
12suprofen44 1210.5ALB, TF
13octreotide44 60 29 1212.5VIP, INS
14enalapril44 50 1211.5ALB, VIP
15antipyrine44 1210.5ALB, TF
16dtpa449.5ALB, TF
17nn304449.5INS, ALB
18captopril44 60 50 29 1213.5VIP, ALB
19fructosamine44 2510.4ALB, INS
20naloxone44 29 50 1212.4ALB, VIP
21repaglinide50 44 1211.4ALB, INS
22glutaraldehyde449.4TF, ALB
23ramipril44 1210.4INS, ALB
24gliclazide44 50 1211.4INS, ALB
25nateglinide44 50 1211.4INS, ALB
26telmisartan44 29 1211.4ALB, INS
27pge1449.4VIP, TF
28rosuvastatin44 50 29 1212.3INS, ALB
29ibmx44 60 2911.3TF, INS, VIP
30vitamin b12449.2ALB, TF
31epinephrine44 25 1211.2TF, INS, VIP
32norepinephrine44 25 1211.2TF, INS, VIP
33stearic acid44 25 1211.2VIP, ALB
34tetracycline44 1210.1ALB, TF
35bicarbonate449.1ALB, VIP, TF
36polyethylene glycol449.1ALB, VIP, TF
37prednisolone44 29 1211.1TF, VIP, ALB
38olanzapine44 50 29 25 1213.1ALB, INS
39histamine44 29 2511.0ALB, VIP, TF
40palmitate448.9ALB, INS, TF
41tacrolimus44 50 1210.9TF, INS, ALB
42aspartate448.9TF, VIP, ALB
43fibrinogen448.9ALB, INS, TF
44myristic acid44 25 1210.7ALB, INS
45creatinine448.6SPINK1, TF, INS, ALB
46thyroxine44 259.5ALB, VIP, INS, TF
47serine448.5SPINK1, INS, VIP, REG1A, CTRC
48lactate448.5TF, INS, VIP, ALB
49alanine448.4ALB, VIP, INS, TF
50calcium44 50 25 1211.2SPINK1, VIP, REG1A, ALB, CTRC

GO Terms for genes affiliated with Fibrocalculous Pancreatic Diabetes

About this section

Cellular components related to Fibrocalculous Pancreatic Diabetes according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1blood microparticleGO:0725629.1ALB, TF
2secretory granule lumenGO:0347749.0INS, TF
3extracellular regionGO:0055767.1ALB, SPINK1, TF, INS, VIP, REG1A

Biological processes related to Fibrocalculous Pancreatic Diabetes according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of vasodilationGO:0459099.5VIP, INS
2regulation of protein localizationGO:0328809.3INS, VIP
3retina homeostasisGO:0018959.1ALB, TF
4platelet degranulationGO:0025769.1ALB, TF
5positive regulation of cell proliferationGO:0082848.6REG1A, VIP, INS

Molecular functions related to Fibrocalculous Pancreatic Diabetes according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:0051799.4VIP, INS

Products for genes affiliated with Fibrocalculous Pancreatic Diabetes

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Fibrocalculous Pancreatic Diabetes

About this section
4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
29IUPHAR
30KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet