MCID: FBR086
MIFTS: 45

Fibrolamellar Carcinoma

Categories: Rare diseases, Liver diseases, Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Fibrolamellar Carcinoma

MalaCards integrated aliases for Fibrolamellar Carcinoma:

Name: Fibrolamellar Carcinoma 12 50
Fibrolamellar Hepatocellular Carcinoma 12 50 56 42 69
Eosinophilic Hepatocellular Carcinoma with Lamellar Fibrosis 50
Polygonal Cell Hepatocellular Carcinoma with Fibrous Stroma 50
Hepatocellular Carcinoma with Increased Stromal Fibrosis 50
Hepatocellular Carcinoma, Fibrolamellar 12
Hepatocellular Fibrolamellar Carcinoma 14
Eosinophilic Glassy Cell Hepatoma 50
Fibrolamellar Oncocytic Hepatoma 50
Oncocytic Hepatocellular Tumor 12
Fibrolamellar Hepatocarcinoma 56
Fl-Hcc 50
Fhcc 56

Characteristics:

Orphanet epidemiological data:

56
fibrolamellar hepatocellular carcinoma
Inheritance: Not applicable; Prevalence: <1/1000000 (United States); Age of onset: Adolescent,Adult;

Classifications:

Orphanet: 56  
Rare hepatic diseases


External Ids:

Disease Ontology 12 DOID:5015
MeSH 42 C537258
NCIt 47 C4131
SNOMED-CT 64 15619004 253018005
Orphanet 56 ORPHA401920
UMLS via Orphanet 70 C0334287
ICD10 via Orphanet 34 C22.0
UMLS 69 C0334287

Summaries for Fibrolamellar Carcinoma

NIH Rare Diseases : 50 fibrolamellar carcinoma (flc) is a rare form of liver cancer which is generally diagnosed in adolescents and young adults (before age 40). many people with early flc have no signs or symptoms of the condition. when present, symptoms are often nonspecific (i.e. abdominal pain, weight loss, malaise) and blamed on other, more common conditions. the exact underlying cause of flc is poorly understood. unlike other forms of liver cancer, flc typically occurs in the absence of underlying liver inflammation or scarring; thus, specific risk factors for this condition remain unidentified. flc is typically treated with surgical resection. last updated: 4/23/2015

MalaCards based summary : Fibrolamellar Carcinoma, also known as fibrolamellar hepatocellular carcinoma, is related to mixed fibrolamellar hepatocellular carcinoma and urethra clear cell adenocarcinoma, and has symptoms including abdominal pain, fever and icterus. An important gene associated with Fibrolamellar Carcinoma is PRKACA (Protein Kinase CAMP-Activated Catalytic Subunit Alpha), and among its related pathways/superpathways are Sertoli-Sertoli Cell Junction Dynamics and NFAT and Cardiac Hypertrophy. The drugs Cyclophosphamide and Fludarabine have been mentioned in the context of this disorder. Affiliated tissues include liver, bone and bone marrow, and related phenotypes are cardiovascular system and homeostasis/metabolism

Disease Ontology : 12 A hepatocellular carcinoma characterized microscopically by laminated fibrous layers interspersed between the tumour cells. The polygonal, deeply eosinophilic tumor cells arise in non-cirrhotic livers.

Wikipedia : 72 Fibrolamellar hepatocellular carcinoma (FHCC) is a rare form of hepatocellular carcinoma (HCC) that... more...

Related Diseases for Fibrolamellar Carcinoma

Diseases related to Fibrolamellar Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 58)
id Related Disease Score Top Affiliating Genes
1 mixed fibrolamellar hepatocellular carcinoma 11.0
2 urethra clear cell adenocarcinoma 10.5 KRT8 SYP
3 metagonimiasis 10.5 ITGA1 ITGAV
4 superior mesenteric artery syndrome 10.5 KRT8 SYP
5 pediatric ependymoma 10.5 KRT8 SYP
6 uterine benign neoplasm 10.5 KRT8 SYP
7 rectum lymphoma 10.5 KRT8 SYP
8 paranasal sinus cancer 10.4 AFP SYP
9 middle ear squamous cell carcinoma 10.4 KRT8 SYP
10 mature teratoma 10.4 AFP SYP
11 classic variant of chromophobe renal cell carcinoma 10.4 KRT8 SYP
12 thymus small cell carcinoma 10.4 AFP SYP
13 malignant teratoma 10.4 AFP SYP
14 cerebellar vermis medulloblastoma 10.4 AFP SYP
15 rete ovarii cystadenofibroma 10.4 AFP SYP
16 pneumothorax 10.4 AFP SYP
17 2q31.1 microdeletion syndrome 10.4 SYP VIM
18 tricuspid valve insufficiency 10.3 AFP SYP
19 neurogenic thoracic outlet syndrome 10.3 SYP VIM
20 skin papilloma 10.3 SYP VIM
21 reticular pattern testicular yolk sac tumor 10.3 SYP VIM
22 adult medulloblastoma 10.3 SYP VIM
23 axonal neuropathy 10.3 SYP VIM
24 anaplastic oligodendroglioma 10.3 SYP VIM
25 vulva adenocarcinoma 10.3 KRT8 SYP
26 behcet's syndrome arthropathy 10.3 SYP VIM
27 volkmann contracture 10.3 CCKBR SYP
28 space motion sickness 10.3 SYP VIM
29 hypersensitivity reaction type iii disease 10.3 AFP SYP
30 papillary glioneuronal tumor 10.3 SYP VIM
31 sebaceous adenoma 10.3 SYP VIM
32 spondyloepimetaphyseal dysplasia, isidor type 10.3 SYP VIM
33 spindle cell liposarcoma 10.3 KRT8 VIM
34 olivopontocerebellar atrophy deafness 10.3 KRT8 VIM
35 pancreatic ductal carcinoma 10.3 SYP VIM
36 group b strep disease in newborns 10.2 SYP VIM
37 ischemia 10.2 AFP SYP
38 glomangioma 10.2 SYP VIM
39 inner ear cancer 10.2 AFP VIM
40 vulvar keratoacanthoma-like carcinoma 10.2 SYP VIM
41 childhood pleomorphic rhabdomyosarcoma 10.1 AFP VIM
42 microcystic meningioma 10.1 KRT8 VIM
43 hepatocellular carcinoma 10.1
44 toxic pneumonitis 10.1 SYP VIM
45 cervical adenomyoma 10.0 SYP VIM
46 sex differentiation disease 10.0 AFP VIM
47 hypogonadism 10.0 AFP SYP
48 conventional malignant hemangiopericytoma 10.0 KRT8 VIM
49 acidophil adenoma 10.0 KRT8 SYP VIM
50 epidermolysa bullosa simplex with muscular dystrophy 10.0 SYP VIM

Graphical network of the top 20 diseases related to Fibrolamellar Carcinoma:



Diseases related to Fibrolamellar Carcinoma

Symptoms & Phenotypes for Fibrolamellar Carcinoma

UMLS symptoms related to Fibrolamellar Carcinoma:


abdominal pain, fever, icterus, malaise

MGI Mouse Phenotypes related to Fibrolamellar Carcinoma:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.7 CCKBR ITGA1 ITGAV ITGB4 KRT8 PRKACA
2 homeostasis/metabolism MP:0005376 9.61 AFP CCKBR ITGA1 ITGAV ITGB4 KRT8
3 renal/urinary system MP:0005367 9.02 ITGA1 ITGAV ITGB4 PRKACA CCKBR

Drugs & Therapeutics for Fibrolamellar Carcinoma

Drugs for Fibrolamellar Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 42)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cyclophosphamide Approved, Investigational Phase 2 50-18-0, 6055-19-2 2907
2
Fludarabine Approved Phase 2 21679-14-1, 75607-67-9 30751
3
Lenograstim Approved Phase 2 135968-09-1
4
Mesna Approved Phase 2 3375-50-6 598
5
Mycophenolate mofetil Approved, Investigational Phase 2 128794-94-5 5281078
6
Mycophenolic acid Approved Phase 2 24280-93-1 446541
7
Prednisone Approved, Vet_approved Phase 2 53-03-2 5865
8
Tacrolimus Approved, Investigational Phase 2 104987-11-3 445643 439492
9
Everolimus Approved Phase 2 159351-69-6 6442177
10
Letrozole Approved, Investigational Phase 2 112809-51-5 3902
11
Leuprolide Approved, Investigational Phase 2 53714-56-0 3911 657181
12
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
13
Sirolimus Approved, Investigational Phase 2 53123-88-9 5284616 6436030 46835353
14
Sunitinib Approved, Investigational Phase 2 341031-54-7, 557795-19-4 5329102
15 Adjuvants, Immunologic Phase 2
16 Alkylating Agents Phase 2
17 Anti-Bacterial Agents Phase 2
18 Antibiotics, Antitubercular Phase 2
19 Anti-Inflammatory Agents Phase 2
20 Antilymphocyte Serum Phase 2
21 Antimetabolites Phase 2
22 Antimetabolites, Antineoplastic Phase 2
23 Antineoplastic Agents, Hormonal Phase 2
24 Antirheumatic Agents Phase 2
25 Calcineurin Inhibitors Phase 2
26 glucocorticoids Phase 2
27 Hematinics Phase 2
28 Hormone Antagonists Phase 2
29 Hormones Phase 2
30 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
31 Immunosuppressive Agents Phase 2
32 Liver Extracts Phase 2
33 Protective Agents Phase 2
34 Antifungal Agents Phase 2
35 Anti-Infective Agents Phase 2
36 Aromatase Inhibitors Phase 2
37 Estrogen Antagonists Phase 2
38 Estrogens Phase 2
39 Fertility Agents Phase 2
40 Steroid Synthesis Inhibitors Phase 2
41 Angiogenesis Inhibitors Phase 2
42 Angiogenesis Modulating Agents Phase 2

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Sequential, Related Donor Partial Liver Transplantation Followed by Bone Marrow Transplantation for Hepatocellular Carcinoma (HCC) Recruiting NCT02702960 Phase 2 Cyclophosphamide;Mesna;Filgrastim;Tacrolimus;mycophenolate mofetil;Prednisone;Antithymocyte globulin;fludarabine
2 A Multi-center, Open-label Study of Oral ENMD-2076 for the Treatment of Patients With Advanced Fibrolamellar Carcinoma Active, not recruiting NCT02234986 Phase 2 ENMD-2076
3 Study of (1) Everolimus, (2) Estrogen Deprivation Therapy (EDT) With Leuprolide + Letrozole and (3) Everolimus + EDT in Patients With Unresectable Fibrolamellar Hepatocellular Carcinoma (FLL-HCC) Active, not recruiting NCT01642186 Phase 2 everolimus;letrozole plus leuprolide;combination of everolimus, letrozole and leuprolide
4 Study of Sunitinib in Patients With Advanced/Inoperable Fibrolamellar Carcinoma Terminated NCT01215565 Phase 2 Sutent
5 Biomarkers in Stored Tumor Samples From Younger Patients With Liver Cancer Withdrawn NCT00899002

Search NIH Clinical Center for Fibrolamellar Carcinoma

Cochrane evidence based reviews: fibrolamellar hepatocellular carcinoma

Genetic Tests for Fibrolamellar Carcinoma

Anatomical Context for Fibrolamellar Carcinoma

MalaCards organs/tissues related to Fibrolamellar Carcinoma:

39
Liver, Bone, Bone Marrow, Testes

Publications for Fibrolamellar Carcinoma

Articles related to Fibrolamellar Carcinoma:

(show all 37)
id Title Authors Year
1
Environmental exposures as a risk factor for fibrolamellar carcinoma. ( 28256571 )
2017
2
Comprehensive analysis of The Cancer Genome Atlas reveals a unique gene and non-coding RNA signature of fibrolamellar carcinoma. ( 28304380 )
2017
3
Fibrolamellar carcinoma: A histologically unique tumor with unique molecular findings. ( 28110996 )
2017
4
Molecular testing for the clinical diagnosis of fibrolamellar carcinoma. ( 28862261 )
2017
5
Duodenal Recurrence of Fibrolamellar Carcinoma 12 Years After Partial Hepatectomy and Adjuvant Chemotherapy. ( 27921059 )
2016
6
The DNAJB1-PRKACA chimera: Candidate biomarker and therapeutic target for fibrolamellar carcinomas. ( 26505878 )
2016
7
Prognosis of Fibrolamellar Carcinoma Compared to Non-cirrhotic Conventional Hepatocellular Carcinoma. ( 27456016 )
2016
8
Fibrolamellar carcinoma versus scirrhous hepatocellular carcinomaa88: diagnostic usefulness of CD68. ( 26712049 )
2015
9
FGFR1 and FGFR2 in fibrolamellar carcinoma. ( 26259677 )
2015
10
Caroli's Syndrome with Incidental Fibrolamellar Carcinoma on Liver Explant. ( 25990596 )
2015
11
DNAJB1-PRKACA is specific for fibrolamellar carcinoma. ( 25698061 )
2015
12
Liver cancer: A model of fibrolamellar carcinoma. ( 26503883 )
2015
13
Multi-institutional analysis of recurrence and survival after hepatectomy for fibrolamellar carcinoma. ( 24844420 )
2014
14
Fibrolamellar carcinoma in a 62 year-old patient with human immunodeficiency virus infection. ( 24908574 )
2014
15
CT and MRI of primary and metastatic fibrolamellar carcinoma: a case series of 37 patients. ( 24896196 )
2014
16
Combined hepatocellular carcinoma and fibrolamellar carcinoma presenting as two adjacent separate lesions in a young boy: first case report from Asia. ( 25374712 )
2013
17
Clinicopathologic characteristics and survival outcomes of patients with fibrolamellar carcinoma: data from the fibrolamellar carcinoma consortium. ( 23505572 )
2013
18
Loss of the orphan nuclear receptor SHP is more pronounced in fibrolamellar carcinoma than in typical hepatocellular carcinoma. ( 22292081 )
2012
19
Cytologic features of fibrolamellar carcinoma with mucin production: A rare variant of combined hepatocellular-cholangiocarcinoma. ( 23008149 )
2012
20
Fibrolamellar carcinoma: 2012 update. ( 24278737 )
2012
21
Fibrolamellar carcinoma: a review with focus on genetics and comparison to other malignant primary liver tumors. ( 21344351 )
2011
22
Fibrolamellar carcinomas are positive for CD68. ( 21113139 )
2011
23
Frequent and distinct aberrations of DNA methylation patterns in fibrolamellar carcinoma of the liver. ( 21060828 )
2010
24
Fibrolamellar carcinoma of the liver exhibits immunohistochemical evidence of both hepatocyte and bile duct differentiation. ( 20495535 )
2010
25
Anterior gradient-2 is overexpressed by fibrolamellar carcinomas. ( 18973922 )
2009
26
Fibrolamellar carcinoma presenting as a pancreatic mass: case report and review of the literature. ( 19415023 )
2009
27
[Fibrolamellar carcinoma of the liver]. ( 19507574 )
2009
28
Epigenetic instability is rare in fibrolamellar carcinomas but common in viral-associated hepatocellular carcinomas. ( 18264082 )
2008
29
Shoulder pain as the first sign of a hepatic fibrolamellar carcinoma in a young man. ( 18568150 )
2008
30
Electronic clinical challenges and images in GI. Fibrolamellar carcinoma. ( 17983790 )
2007
31
Review of the clinicopathologic features of fibrolamellar carcinoma. ( 17452818 )
2007
32
Fibrolamellar carcinomas show overexpression of genes in the RAS, MAPK, PIK3, and xenobiotic degradation pathways. ( 17367606 )
2007
33
Combined fibrolamellar carcinoma and cholangiocarcinoma exhibiting biphenotypic antigen expression: a case report. ( 16049296 )
2005
34
Expression and processing of gastrin in hepatocellular carcinoma, fibrolamellar carcinoma and cholangiocarcinoma. ( 10190738 )
1999
35
Fibrolamellar carcinoma of the liver: composition of the extracellular matrix and expression of cell-matrix and cell-cell adhesion molecules. ( 8903387 )
1996
36
Expression of the neurotensin gene in fetal human liver and fibrolamellar carcinoma. ( 7944660 )
1994
37
Abundant expression of cytokeratin 7 in fibrolamellar carcinoma of the liver. ( 1699871 )
1990

Variations for Fibrolamellar Carcinoma

Cosmic variations for Fibrolamellar Carcinoma:

9 (show top 50) (show all 702)
id Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA Conf
1 COSM43833 TP53 liver,NS,carcinoma,hepatocellular carcinoma c.578A>C p.H193P 28
2 COSM10771 TP53 liver,NS,carcinoma,hepatocellular carcinoma c.749C>T p.P250L 28
3 COSM10659 TP53 liver,NS,carcinoma,hepatocellular carcinoma c.817C>T p.R273C 28
4 COSM43785 TP53 liver,NS,carcinoma,hepatocellular carcinoma c.795G>A p.L265L 28
5 COSM10883 TP53 liver,NS,carcinoma,hepatocellular carcinoma c.731G>A p.G244D 28
6 COSM11542 TP53 liver,NS,carcinoma,hepatocellular carcinoma c.703A>G p.N235D 28
7 COSM45047 TP53 liver,NS,carcinoma,hepatocellular carcinoma c.515T>G p.V172G 28
8 COSM10733 TP53 liver,NS,carcinoma,hepatocellular carcinoma c.574C>T p.Q192* 28
9 COSM43737 TP53 liver,NS,carcinoma,hepatocellular carcinoma c.830G>A p.C277Y 28
10 COSM43778 TP53 liver,NS,carcinoma,hepatocellular carcinoma c.713G>T p.C238F 28
11 COSM10648 TP53 liver,NS,carcinoma,hepatocellular carcinoma c.524G>A p.R175H 28
12 COSM44956 TP53 liver,NS,carcinoma,hepatocellular carcinoma c.808T>G p.F270V 28
13 COSM11552 TP53 liver,NS,carcinoma,hepatocellular carcinoma c.775G>T p.D259Y 28
14 COSM44091 TP53 liver,NS,carcinoma,hepatocellular carcinoma c.746G>A p.R249K 28
15 COSM43665 TP53 liver,NS,carcinoma,hepatocellular carcinoma c.746G>C p.R249T 28
16 COSM10743 TP53 liver,NS,carcinoma,hepatocellular carcinoma c.848G>C p.R283P 28
17 COSM44129 TP53 liver,NS,carcinoma,hepatocellular carcinoma c.729G>A p.M243I 28
18 COSM44511 TP53 liver,NS,carcinoma,hepatocellular carcinoma c.753C>A p.I251I 28
19 COSM10725 TP53 liver,NS,carcinoma,hepatocellular carcinoma c.701A>G p.Y234C 28
20 COSM44571 TP53 liver,NS,carcinoma,hepatocellular carcinoma c.581T>G p.L194R 28
21 COSM11205 TP53 liver,NS,carcinoma,hepatocellular carcinoma c.796G>C p.G266R 28
22 COSM44808 TP53 liver,NS,carcinoma,hepatocellular carcinoma c.503A>C p.H168P 28
23 COSM44510 TP53 liver,NS,carcinoma,hepatocellular carcinoma c.717C>G p.N239K 28
24 COSM11183 TP53 liver,NS,carcinoma,hepatocellular carcinoma c.799C>T p.R267W 28
25 COSM43635 TP53 liver,NS,carcinoma,hepatocellular carcinoma c.536A>T p.H179L 28
26 COSM10893 TP53 liver,NS,carcinoma,hepatocellular carcinoma c.824G>A p.C275Y 28
27 COSM43850 TP53 liver,NS,carcinoma,hepatocellular carcinoma c.659A>C p.Y220S 28
28 COSM10756 TP53 liver,NS,carcinoma,hepatocellular carcinoma c.827C>T p.A276V 28
29 COSM43597 TP53 liver,NS,carcinoma,hepatocellular carcinoma c.538G>T p.E180* 28
30 COSM43846 TP53 liver,NS,carcinoma,hepatocellular carcinoma c.487T>C p.Y163H 28
31 COSM10757 TP53 liver,NS,carcinoma,hepatocellular carcinoma c.738G>C p.M246I 28
32 COSM43687 TP53 liver,NS,carcinoma,hepatocellular carcinoma c.641A>G p.H214R 28
33 COSM44623 TP53 liver,NS,carcinoma,hepatocellular carcinoma c.487T>A p.Y163N 28
34 COSM6815 TP53 liver,NS,carcinoma,hepatocellular carcinoma c.461G>T p.G154V 28
35 COSM10656 TP53 liver,NS,carcinoma,hepatocellular carcinoma c.742C>T p.R248W 28
36 COSM10714 TP53 liver,NS,carcinoma,hepatocellular carcinoma c.473G>T p.R158L 28
37 COSM43791 TP53 liver,NS,carcinoma,hepatocellular carcinoma c.994-2A>T p.? 28
38 COSM1651731 TP53 liver,NS,carcinoma,hepatocellular carcinoma c.957G>A p.K319K 28
39 COSM44935 TP53 liver,NS,carcinoma,hepatocellular carcinoma c.724T>A p.C242S 28
40 COSM10722 TP53 liver,NS,carcinoma,hepatocellular carcinoma c.853G>A p.E285K 28
41 COSM44227 TP53 liver,NS,carcinoma,hepatocellular carcinoma c.854A>T p.E285V 28
42 COSM44672 TP53 liver,NS,carcinoma,hepatocellular carcinoma c.658T>A p.Y220N 28
43 COSM44320 TP53 liver,NS,carcinoma,hepatocellular carcinoma c.484A>T p.I162F 28
44 COSM44063 TP53 liver,NS,carcinoma,hepatocellular carcinoma c.389T>G p.L130R 28
45 COSM45747 TP53 liver,NS,carcinoma,hepatocellular carcinoma c.620A>C p.D207A 28
46 COSM10779 TP53 liver,NS,carcinoma,hepatocellular carcinoma c.818G>T p.R273L 28
47 COSM44321 TP53 liver,NS,carcinoma,hepatocellular carcinoma c.712T>C p.C238R 28
48 COSM43967 TP53 liver,NS,carcinoma,hepatocellular carcinoma c.751A>T p.I251F 28
49 COSM44469 TP53 liver,NS,carcinoma,hepatocellular carcinoma c.812A>T p.E271V 28
50 COSM10727 TP53 liver,NS,carcinoma,hepatocellular carcinoma c.438G>A p.W146* 28

Expression for Fibrolamellar Carcinoma

Search GEO for disease gene expression data for Fibrolamellar Carcinoma.

Pathways for Fibrolamellar Carcinoma

Pathways related to Fibrolamellar Carcinoma according to GeneCards Suite gene sharing:

(show all 14)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.58 ITGA1 ITGAV ITGB4 PRKACA
2
Show member pathways
12.52 ITGA1 ITGAV ITGB4 PRKACA
3
Show member pathways
12.48 ITGA1 ITGAV ITGB4 PRKACA
4
Show member pathways
12.43 ITGA1 ITGAV ITGB4 PRKACA
5 12.36 ITGA1 ITGAV ITGB4 PRKACA
6
Show member pathways
12.12 ITGA1 ITGAV ITGB4
7
Show member pathways
12.03 ITGA1 ITGAV ITGB4
8
Show member pathways
11.76 ITGA1 ITGAV ITGB4
9
Show member pathways
11.73 ITGA1 ITGAV ITGB4
10 11.55 ITGA1 ITGAV ITGB4
11 11.26 ITGA1 ITGAV ITGB4
12 11.25 ITGA1 ITGAV ITGB4 PRKACA
13 10.79 ITGAV ITGB4 KRT8 VIM
14 10.73 ITGA1 ITGAV ITGB4

GO Terms for Fibrolamellar Carcinoma

Cellular components related to Fibrolamellar Carcinoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.5 DNAJB1 ITGA1 ITGAV ITGB4 KRT8 PRKACA
2 integrin complex GO:0008305 8.8 ITGA1 ITGAV ITGB4

Biological processes related to Fibrolamellar Carcinoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular matrix organization GO:0030198 9.33 ITGA1 ITGAV ITGB4
2 digestive tract development GO:0048565 9.26 CCKBR ITGB4
3 cell-matrix adhesion GO:0007160 9.13 ITGA1 ITGAV ITGB4
4 integrin-mediated signaling pathway GO:0007229 8.8 ITGA1 ITGAV ITGB4

Molecular functions related to Fibrolamellar Carcinoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 insulin-like growth factor I binding GO:0031994 8.96 ITGAV ITGB4
2 neuregulin binding GO:0038132 8.62 ITGAV ITGB4

Sources for Fibrolamellar Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....