MCID: FBR019
MIFTS: 34

Fibromatosis malady

Summaries for Fibromatosis

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42NIH Rare Diseases, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 Fibromatosis refers to a group of conditions characterized by overgrowths of skin and connective tissue called fibromas. these fibromas are usually benign (non-cancerous). fibromatosis can be classified by a person's age or by the location of the fibromas. the cause of fibromatosis is often unknown, and treatment depends on the individual disease. last updated: 5/10/2010

MalaCards: Fibromatosis is related to gingivitis and pseudosarcomatous fibromatosis. An important gene associated with Fibromatosis is SOS1 (son of sevenless homolog 1 (Drosophila)), and among its related pathways are Glioma and Hyaluronan uptake and degradation. The compounds procollagen and orcein have been mentioned in the context of this disorder. Affiliated tissues include skin, and related mouse phenotypes are mortality/aging and cardiovascular system.

Wikipedia:63 The term fibromatosis refers to a group of benign soft tissue tumors which have certain characteristics... more...

Aliases & Classifications for Fibromatosis

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42NIH Rare Diseases, 44Novoseek, 60UMLS
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Aliases & Descriptions:

fibromatosis 42 44 60


Related Diseases for Fibromatosis

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17GeneCards, 18GeneDecks
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Diseases related to Fibromatosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 208)
idRelated DiseaseScoreTop Affiliating Genes
1gingivitis31.2MMP1
2pseudosarcomatous fibromatosis30.6RGPD1
3desmoid tumor30.5ACTC1, DES, CTNNB1
4gastrointestinal stromal tumor30.4ACTC1, DES, VIM
5fibromatosis, gingival30.4SOS1, CD36, MMP2, MMP1, SERPINH1, TGFB1
6fasciitis30.3ACTC1
7spindle cell carcinoma30.3VIM, DES, ACTC1
8sarcoma30.3ACTC1, DES, VIM
9infantile myofibromatosis29.9DES
10lipoma29.9DES
11fibrosarcoma29.9VIM, DES, CD36, MMP2, MMP1, ACTC1
12breast cancer29.9VIM, CTNNB1, MMP2, MMP1, ACTC1, TGFB1
13squamous cell carcinoma29.9VIM, CTNNB1, MMP2, MMP1, ACTC1, SERPINH1
14colon cancer29.7CTNNB1, CD36, MMP2
15leiomyoma29.7VIM, DES, ACTC1
16rhabdomyosarcoma29.7VIM, DES, ACTC1
17gingival overgrowth29.7ANTXR2, CD36, MMP1, TGFB1
18fibrous histiocytoma29.7ACTC1, DES, VIM
19arthritis29.7MMP2, MMP1, TGFB1
20rheumatoid arthritis29.7HAS1, HAS3, CD36, MMP2, MMP1, SERPINH1
21melanoma29.7VIM, CTNNB1, DES, CD36, MMP2, MMP1
22basal cell carcinoma29.7ACTC1, MMP1, CTNNB1
23juvenile hyaline fibromatosis10.5
24gingival fibromatosis with hypertrichosis10.5
25hypertrichosis10.4
26infantile digital fibromatosis10.3
27plantar fascial fibromatosis10.3
28periodontitis10.2
29gingival fibromatosis, 210.2
30gingival fibromatosis, 310.2
31gingival fibromatosis, 410.2
32hyalinosis, inherited systemic10.2
33gingival fibromatosis, 110.2
34amelogenesis imperfecta and gingival fibromatosis syndrome10.2
35aggressive periodontitis10.2
36breast metaplastic carcinoma10.2
37congenital generalized fibromatosis10.2
38jones syndrome10.2
39gingival fibromatosis with distinctive facies10.2
40cherubism10.1
41familial adenomatous polyposis10.1
42peritonitis10.1
43fibromatosis multiple non ossifying10.1
44ramon syndrome10.1
45gingival fibromatosis - facial dysmorphism10.1
46familial dupuytren contracture10.1
47liver cirrhosis10.0TGFB1
48oral submucous fibrosis10.0MMP1
49hepatitis10.0SOS1
50pancreatitis10.0TGFB1

Graphical network of the top 20 diseases related to Fibromatosis:



Diseases related to fibromatosis

Clinical Features for Fibromatosis

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Drugs & Therapeutics for Fibromatosis

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Fibromatosis

Drug clinical trials:

Search ClinicalTrials for Fibromatosis

Search NIH Clinical Center for Fibromatosis

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Genetic Tests for Fibromatosis

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Anatomical Context for Fibromatosis

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32MalaCards
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MalaCards organs/tissues related to Fibromatosis:

32
Skin

Animal Models for Fibromatosis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Fibromatosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:001076810.1SOS1, CTNNB1, DES, ANTXR2, CD36, FGF19
2MP:000538510.0SERPINH1, VIM, SOS1, CTNNB1, IER3, DES
3MP:000536910.0SOS1, IER3, CD36, MMP2, ACTC1, TGFB1

Publications for Fibromatosis

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Genetic Variations for Fibromatosis

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Expression for genes affiliated with Fibromatosis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Fibromatosis

Search GEO for disease gene expression data for Fibromatosis.

Pathways for genes affiliated with Fibromatosis

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29KEGG, 53Reactome, 51QIAGEN, 37NCBI BioSystems Database, 12EMD Millipore
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Compounds for genes affiliated with Fibromatosis

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44Novoseek, 11DrugBank, 24HMDB, 49PharmGKB, 28IUPHAR, 59Tocris Bioscience, 2BitterDB
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Compounds related to Fibromatosis according to GeneCards/GeneDecks:

(show top 50)    (show all 86)
idCompoundScoreTop Affiliating Genes
1procollagen4410.9TGFB1
2orcein4410.8VIM, ACTC1, DES
3phxa 854410.8MMP1, MMP2
4s 1004410.8ACTC1, DES, VIM
5reticulin4410.8DES, ACTC1, VIM
6mucicarmine4410.8DES, ACTC1, VIM
7silicone4410.8CD36, MMP2, VIM
8hydroxyproline44 11 2412.8MMP1, TGFB1, MMP2, CD36
9dexamethasone44 49 28 1113.8HAS3, CTNNB1, TGFB1
10hematoxylin4410.8ACTC1, MMP1, DES, VIM
11phalloidin4410.7VIM, DES, CTNNB1
12candesartan44 28 1112.7TGFB1, MMP1, MMP2
13creatinine4410.7TGFB1, MMP1, MMP2, CD36, ACTC1
14formaldehyde44 2411.7VIM, TGFB1, ACTC1, MMP1, DES
15serine4410.7SOS1, DES, MMP2, TGFB1, MMP1
16zoledronic acid4410.7MMP1, CD36, MMP2
17l-ascorbic acid 2-phosphate4410.7CD36, TGFB1
18biotin44 11 2412.7DES, CTNNB1, ACTC1, VIM
19cytochalasin d44 5911.7MMP2, TGFB1, MMP1, CD36, CTNNB1, VIM
20tgf beta14410.7TGFB1, CTNNB1, VIM, MMP2, CD36, MMP1
2112-o-tetradecanoylphorbol 13-acetate4410.7VIM, MMP1, MMP2, TGFB1, DES
22halofuginone4410.7MMP2, CD36
23hydrocortisone44 2 59 1113.7VIM, HAS1, HAS3, MMP1, MMP2, CD36
24adriamycin4410.7CTNNB1, VIM, DES, CD36
25cgs-27023a4410.7MMP1, MMP2
26b 7234410.7DES, VIM, ACTC1
27glycosaminoglycan4410.7CD36, MMP1, ACTC1, TGFB1, HAS3, HAS1
28rosiglitazone44 49 28 11 2414.7MMP2, MMP1, TGFB1, CD36
29sb 20358044 5911.7VIM, TGFB1, MMP1, MMP2, CD36, CTNNB1
30troglitazone44 28 59 1113.7MMP1, CD36, TGFB1, MMP2
31matrigel4410.7TGFB1, ACTC1, MMP1, MMP2, CD36, VIM
32paraffin4410.6CTNNB1, VIM, TGFB1, ACTC1, MMP1, MMP2
33alendronate44 49 1112.6MMP1, CD36, MMP2
34hyaluronic acid44 2411.6HAS3, HAS1, VIM, MMP2, MMP1, TGFB1
35progesterone44 59 28 11 2414.6MMP2, ACTC1, VIM, CTNNB1, DES, MMP1
36vegf4410.6MMP1, CD36, MMP2, VIM, ACTC1, CTNNB1
37alginate4410.6CD36
38h2o24410.6DES, VIM, MMP2, MMP1, CTNNB1, CD36
39retinoic acid44 2411.6TGFB1, HAS3, VIM, CTNNB1, DES, CD36
40bromodeoxyuridine4410.6DES, CTNNB1, VIM, TGFB1
41dihydrotestosterone44 28 11 2413.6VIM, CTNNB1, TGFB1, DES
42testosterone44 59 11 2413.5VIM, CTNNB1, MMP1, MMP2, DES, ACTC1
43herbimycin a44 5911.5MMP1, CTNNB1, CD36, MMP2
44doxorubicin44 49 1112.5TGFB1, MMP1, CTNNB1, DES, VIM
45ns 39844 5911.5MMP2, MMP1, TGFB1
46bafilomycin a144 59 1112.5SERPINH1, MMP2, DES
47thps4410.4MMP2, MMP1
483-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide4410.4MMP2, DES, TGFB1
49benzylamide4410.3TGFB1, CD36
50vgvapg4410.1MMP2, MMP1

GO Terms for genes affiliated with Fibromatosis

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16Gene Ontology
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Cellular components related to Fibromatosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1fascia adherensGO:00591610.4DES, CTNNB1

Biological processes related to Fibromatosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrix assemblyGO:08502910.5TGFB1, HAS3, HAS1
2muscle filament slidingGO:03004910.4ACTC1, DES, VIM
3extracellular polysaccharide biosynthetic processGO:04522610.4HAS3, HAS1
4extracellular matrix organizationGO:03019810.3TGFB1, SERPINH1, MMP1, MMP2
5hyaluronan biosynthetic processGO:03021310.3HAS1, HAS3
6positive regulation of apoptotic processGO:04306510.0TGFB1, IER3, CTNNB1, SOS1

Molecular functions related to Fibromatosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hyaluronan synthase activityGO:05050110.4HAS3, HAS1

Products for genes affiliated with Fibromatosis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Fibromatosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet