MCID: FBR047
MIFTS: 52

Fibromyalgia malady

Summaries for Fibromyalgia

Sources:
34MedlinePlus, 3CDC, 64Wikipedia, 33MalaCards
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MedlinePlus:34 Fibromyalgia is a disorder that causes muscle pain and fatigue. people with fibromyalgia have "tender points" on the body. tender points are specific places on the neck, shoulders, back, hips, arms, and legs. these points hurt when pressure is put on them. people with fibromyalgia may also have other symptoms, such as trouble sleeping morning stiffness headaches painful menstrual periods tingling or numbness in hands and feet problems with thinking and memory (sometimes called "fibro fog") no one knows what causes fibromyalgia. anyone can get it, but it is most common in middle-aged women. people with rheumatoid arthritis and other autoimmune diseases are particularly likely to develop fibromyalgia. there is no cure for fibromyalgia, but medicine can help you manage your symptoms. getting enough sleep, exercising, and eating well may also help. nih: national institute of arthritis and musculoskeletal and skin diseases

MalaCards: Fibromyalgia is related to chronic fatigue syndrome and arthritis. An important gene associated with Fibromyalgia is HTR3A (5-hydroxytryptamine (serotonin) receptor 3A, ionotropic), and among its related pathways are Monoamine GPCRs and Selected targets of CREB1. The compounds 5-hydroxytryptophan and mhpg have been mentioned in the context of this disorder. Affiliated tissues include whole blood, brain and cortex, and related mouse phenotypes are integument and behavior/neurological.

CDC:3 NOTE: for the following sections using data based on ICD9-CM codes, there is no specific single code for fibromyalgia. According to coding rules, fibromyalgia is coded to 729.1 which is labeled “Myositis and Myalgia, unspecified” and can include other conditions. Thus, numbers based on ICDM9-CM code 729.1 for mortality, ambulatory care and hospitalizations may be overestimates.

Wikipedia:64 Fibromyalgia (FM or FMS) is characterised by chronic widespread pain and allodynia (a heightened and... more...

Aliases & Classifications for Fibromyalgia

Sources:
10DISEASES, 45Novoseek, 34MedlinePlus, 61UMLS, 25ICD10
See all sources

Related Diseases for Fibromyalgia

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Fibromyalgia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 167)
idRelated DiseaseScoreTop Affiliating Genes
1chronic fatigue syndrome31.0SUN2, SLC6A4, CRH
2arthritis30.7NPS, TACR1
3sleep disorder30.3NPS
4irritable bowel syndrome30.2SLC6A4, CRH, HTR3A
5serotonin syndrome30.1HTR2A, HTR3A
6osteoarthritis30.0NPY, TACR1, TSPO
7blindness29.8TSPO
8anxiety disorder29.8HTR3A, CRH, SLC6A4
9bipolar disorder29.8HTR3A, HTR2A, SLC6A4
10restless legs syndrome29.8HTR3A
11memory impairment29.8TSPO, TRH, HTR2A
12hypoglycemia29.8COMT, HTR2A, NPY, CRH, TRH
13chronic interstitial cystitis29.8P2RX3, TSPO
14myofascial pain syndrome10.6
15chronic pain10.6
16n syndrome10.5
17alexithymia10.3
18dysautonomia10.3
19multiple chemical sensitivity10.2
20autonomic dysfunction10.2
21back pain10.2
22eosinophilia-myalgia syndrome10.2
23rheumatic disease10.2
24psoriatic arthritis10.2
25pain disorder10.1
26somatoform disorder10.1
27bod syndrome10.1
28headache10.1
29radiculopathy10.0
30systemic lupus erythematosus10.0
31spondyloarthropathy10.0
32short syndrome10.0
33postural orthostatic tachycardia syndrome10.0
34mass syndrome10.0
35whiplash10.0
36eating disorder10.0SLC6A4
37ischemia10.0PNOC
38borderline personality disorder10.0SLC6A4
39drug dependence10.0SLC6A4, PNOC
40cystitis10.0TACR1
41substance abuse10.0SLC6A4, CRH
42cocaine dependence10.0SLC6A4
43cluster headache10.0PNOC, HTR3A
44constipation10.0SLC6A4, HTR3A
45melancholia10.0CRH, TRH
46thyroiditis10.0TRH
47seasonal affective disorder10.0SLC6A4, CRH, HTR2A
48social phobia10.0COMT, HTR3A, SLC6A4
49panic disorder10.0HTR3A, CRH, SLC6A4, TSPO
50amnestic disorder10.0HTR3A, PREP, TSPO

Graphical network of the top 20 diseases related to Fibromyalgia:



Diseases related to fibromyalgia

Clinical Features for Fibromyalgia

Drugs & Therapeutics for Fibromyalgia

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Fibromyalgia

Drug clinical trials:

Search ClinicalTrials for Fibromyalgia

Search NIH Clinical Center for Fibromyalgia

Search CenterWatch for Fibromyalgia

Genetic Tests for Fibromyalgia

Anatomical Context for Fibromyalgia

Sources:
33MalaCards
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MalaCards organs/tissues related to Fibromyalgia:

33
Whole blood, Brain, Cortex, Heart, Skeletal muscle, Small intestine, Lung, Thyroid, Breast, Skin, Monocytes, T cells, B cells, Endothelial, Cingulate cortex, Adrenal cortex, Pituitary

Animal Models for Fibromyalgia or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Fibromyalgia

Sources:
51PubMed
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Articles related to Fibromyalgia:

(show top 50)    (show all 735)
idTitleAuthorsYear
1
Validation of a Persian version of the Fibromyalgia Impact Questionnaire (FIQ-P). (24166211)
2014
2
Research to encourage exercise for fibromyalgia (REEF): use of motivational interviewing, outcomes from a randomized-controlled trial. (23042474)
2013
3
Validation of a Spanish version of the Revised Fibromyalgia Impact Questionnaire (FIQR). (23915386)
2013
4
Feasibility of Interactive Technology for Symptom Monitoring in Patients with Fibromyalgia. (23434124)
2013
5
Increased brain responses during subjectively-matched mechanical pain stimulation in fibromyalgia patients as evidenced by MEG. (23121899)
2013
6
Increased levels of IL-17A in patients with fibromyalgia. (24021410)
2013
7
Growth hormone treatment for sustained pain reduction and improvement in quality of life in severe fibromyalgia-too important to be tarnished by inconsistencies. (23415782)
2013
8
Alexithymia and fibromyalgia: clinical evidence. (24348453)
2013
9
Epigenetic alterations and an increased frequency of micronuclei in women with fibromyalgia. (24058735)
2013
10
Circadian rhythm of serum cortisol in female patients with fibromyalgia syndrome. (24426206)
2013
11
Emotional modulation of pain and spinal nociception in fibromyalgia. (23622762)
2013
12
Ozone therapy as add-on treatment in fibromyalgia management by rectal insufflation: an open-label pilot study. (23046293)
2013
13
Serotonin and noradrenaline reuptake inhibitors (SNRIs) for fibromyalgia syndrome. (23440848)
2013
14
Isokinetic muscle performance of the hip and ankle muscles in women with fibromyalgia. (24131514)
2013
15
Do participation and personalization matter? A model-driven evaluation of an Internet-based patient education intervention for fibromyalgia patients. (23664234)
2013
16
Primary attributions in women suffering fibromyalgia emphasize the perception of a disruptive onset for a long-lasting pain problem. (23438720)
2013
17
Review of Overlap Between Thermoregulation and Pain Modulation in Fibromyalgia. (23887348)
2013
18
In-Patient Treatment of Fibromyalgia: A Controlled Nonrandomized Comparison of Conventional Medicine versus Integrative Medicine including Fasting Therapy. (23431352)
2013
19
Agomelatine in the treatment of fibromyalgia: a 12-week, open-label, uncontrolled preliminary study. (23764682)
2013
20
Patients' and professionals' views on managing fibromyalgia. (23457682)
2013
21
Kynurenine Pathway Pathologies: do Nicotinamide and Other Pathway Co-Factors have a Therapeutic Role in Reduction of Symptom Severity, Including Chronic Fatigue Syndrome (CFS) and Fibromyalgia (FM). (23922501)
2013
22
Interdisciplinary Treatment of Patients with Fibromyalgia: Improvement of Their Health-Related Quality of Life. (24279638)
2013
23
Development of a multidimensional measure of fibromyalgia symptomatology: the comprehensive rating scale for fibromyalgia symptomatology. (23597325)
2013
24
Do weather changes influence pain levels in women with fibromyalgia, and can psychosocial variables moderate these influences? (24132549)
2013
25
Sono-myography and sono-myoelastography of the tender points of women with fibromyalgia. (23932269)
2013
26
Validation of an adapted arabic version of fibromyalgia syndrome impact questionnaire. (23681020)
2013
27
Prospective study of the use of healthcare resources and economic costs in patients with fibromyalgia after treatment in routine medical practice. (22935246)
2012
28
Identification of subgroups among fibromyalgia patients. (23024969)
2012
29
Alexithymia and psychological distress in fibromyalgia: prevalence and relation with quality of life. (23110722)
2012
30
Psychiatric problems in fibromyalgia: clinical and neurobiological links between mood disorders and fibromyalgia. (23024971)
2012
31
Absence of xenotropic murine leukemia virus-related virus in Italian patients affected by chronic fatigue syndrome, fibromyalgia, or rheumatoid arthritis. (22697086)
2012
32
Experience-sampling methodology with a mobile device in fibromyalgia. (23304132)
2012
33
Chronic fatigue syndrome and fibromyalgia: a status report in 2010. (21250522)
2010
34
High prevalence of restless legs syndrome among patients with fibromyalgia: a controlled cross-sectional study. (20957840)
2010
35
Serotonin receptor (5-HT 2A) and catechol-O-methyltransferase (COMT) gene polymorphisms: triggers of fibromyalgia? (21125150)
2010
36
Interstitial cystitis/painful bladder syndrome and associated medical conditions with an emphasis on irritable bowel syndrome, fibromyalgia and chronic fatigue syndrome. (20719340)
2010
37
Genetic influences on the dynamics of pain and affect in fibromyalgia. (20230086)
2010
38
Implications of forgiveness enhancement in patients with fibromyalgia and chronic fatigue syndrome. (20658426)
2010
39
Parental bonding and alexithymia in adults with fibromyalgia. (18354064)
2008
40
Catechol-O-methyltransferase gene haplotypes in Mexican and Spanish patients with fibromyalgia. (17961261)
2007
41
The low-dose dexamethasone suppression test in fibromyalgia. (17188125)
2007
42
Common etiology of posttraumatic stress disorder, fibromyalgia, chronic fatigue syndrome and multiple chemical sensitivity via elevated nitric oxide/peroxynitrite. (11461161)
2001
43
The growth hormone (GH)-releasing hormone-GH-insulin-like growth factor-1 axis in patients with fibromyalgia syndrome. (10487713)
1999
44
Secretory pattern of GH, TSH, thyroid hormones, ACTH, cortisol, FSH, and LH in patients with fibromyalgia syndrome following systemic injection of the relevant hypothalamic-releasing hormones. (10025090)
1998
45
Possible concomitant fibromyalgia in systemic lupus erythematosus patients with overt central nervous system disease but with cognitive deficits: comment on the article by Kozora et al. (9259439)
1997
46
Glucocorticoid receptors, fibromyalgia and low back pain. (9483705)
1997
47
Problems with myofascial pain syndrome and fibromyalgia syndrome. (8618650)
1996
48
Pathogenetic aspects of responsiveness to ondansetron (5-hydroxytryptamine type 3 receptor antagonist) in patients with primary fibromyalgia syndrome--a preliminary study. (8856622)
1996
49
Tender points/fibromyalgia vs. trigger points/myofascial pain syndrome: a need for clarity in terminology and differential diagnosis. (7595112)
1995
50
Biochemical changes in relation to a maximal exercise test in patients with fibromyalgia. (8205747)
1994

Genetic Variations for Fibromyalgia

Expression for genes affiliated with Fibromyalgia

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Fibromyalgia

Search GEO for disease gene expression data for Fibromyalgia.

Pathways for genes affiliated with Fibromyalgia

Sources:
38NCBI BioSystems Database, 50PharmGKB, 54Reactome, 12EMD Millipore, 30KEGG, 52QIAGEN
See all sources

Compounds for genes affiliated with Fibromyalgia

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 24HMDB, 29IUPHAR, 2BitterDB, 60Tocris Bioscience
See all sources

Compounds related to Fibromyalgia according to GeneCards/GeneDecks:

(show top 50)    (show all 175)
idCompoundScoreTop Affiliating Genes
15-hydroxytryptophan4510.8HTR2A, CRH, HTR3A, SLC6A4
2mhpg4510.8NPY, CRH, SLC6A4, COMT
3citalopram50 45 11 2413.8HTR3A, HTR2A, SLC6A4, TACR1
4mirtazapine50 45 1112.8CRH, SLC6A4, HTR3A, HTR2A
58-hydroxy-2-(di-n-propylamino)tetralin4510.8HTR2A, HTR3A, SLC6A4
6alpha-aminoisobutyric acid45 1111.8NPY, CRH, PNOC
7fluvoxamine45 50 1112.8HTR3A, HTR2A, TSPO, SLC6A4
8clomipramine45 50 1112.8TSPO, HTR2A, CRH, TACR1, SLC6A4, HTR3A
9paroxetine45 50 29 1113.8SLC6A4, TACR1, HTR2A, HTR3A, COMT
10fluoxetine50 45 29 1113.8HTR3A, HTR2A, CRH, TACR1, SLC6A4
11fenfluramine29 45 1112.8HTR2A, SLC6A4, HTR3A, NPY, CRH, TRH
12m-chlorophenylpiperazine4510.8HTR3A, SLC6A4, HTR2A
13yohimbine45 29 2 1113.8HTR3A, HTR2A, CRH, NPY
14dsip4510.7NPY, TSC22D3, CRH
15mcpp4510.7SLC6A4, HTR2A, HTR3A
16opiate4510.7TSPO, CRH, SLC6A4, PNOC, NPY, TACR1
17nmda45 2911.7TSPO, TACR1, GRIN2D, COMT, PNOC
18octadecaneuropeptide4510.7TSPO, NPY, PNOC
19clozapine45 29 50 1113.7COMT, SLC6A4, TACR1, HTR3A, HTR2A
202-methyl-5-ht45 2911.7TACR1, HTR3A, HTR2A
21capsaicin45 2911.7CRH, TACR1, P2RX3, PNOC, NPY
22haloperidol45 29 2 50 1114.7NPY, SLC6A4, HTR3A, HTR2A, TRH, TACR1
23cocaine45 1111.7PNOC, TSPO, SLC6A4, CRH, TRH, COMT
24atropine45 29 1112.7PNOC, TRH, TACR1, CRH, NPY
25morphine45 50 29 1113.7TRH, TACR1, PNOC, TSPO, COMT
26risperidone29 45 50 60 11 2415.7COMT, SLC6A4, HTR2A, HTR3A
27gaba4510.7PNOC, SLC6A4, TSC22D3, NPY, TSPO, TRH
28desipramine45 50 1112.7HTR2A, CRH, TRH, SLC6A4
29acetylcholine45 50 29 11 2414.7HTR3A, TSPO, PNOC, P2RX3, TACR1, TRH
305-hydroxytryptamine4510.7TACR1, CRH, PNOC, SLC6A4, NPY, HTR3B
31guanethidine45 1111.7NPY, PNOC, TACR1
32pindolol45 29 1112.7HTR3A, HTR2A, SLC6A4
33naloxone45 50 29 1113.7CRH, TRH, PNOC, TSPO
34dopamine45 29 11 2413.6HTR3A, HTR2A, PNOC, TSPO, SLC6A4, TACR1
35histamine45 29 2412.6HTR3A, CRH, NPY, TSPO, PNOC, TACR1
36clonidine45 29 1112.6TACR1, SLC6A4, TRH, NPY
37norepinephrine45 11 2412.6CRH, NPY, HTR2A, HTR3A, COMT, TSPO
38tegaserod45 29 1112.6HTR2A, SLC6A4, HTR3A
39glutamate4510.6COMT, NPY, PREP, GRIN2D, CRH, SLC6A4
40buspirone45 29 1112.6HTR3A, TSPO, HTR2A
41arginine4510.6TSPO, HTR3B, SLC6A4, TRH, CRH, NPY
42nicotine45 50 29 1113.6TSPO, COMT, CRH, SLC6A4, NPY
43imipramine45 50 29 11 2414.5SLC6A4, TACR1, HTR2A, HTR3A
44estrogen4510.5CRH, NPY, COMT, PNOC, TRH, SERPINA1
45octreotide45 60 29 1113.5NPY, TRH, TACR1, CRH
46allopregnanolone4510.4TSPO, NPY
47nefazodone45 50 1112.4SLC6A4, HTR2A, HTR3A
48acth4510.4TSC22D3, NPY, CRH, SERPINA1, TRH
49tetrodotoxin45 60 2912.3NPY, TACR1, CRH, HTR3A
50baclofen45 1111.1NPY, TSPO, PNOC

GO Terms for genes affiliated with Fibromyalgia

Sources:
16Gene Ontology
See all sources

Cellular components related to Fibromyalgia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral to plasma membraneGO:00588710.3SLC6A4, P2RX3, TACR1, HTR3B, HTR2A, HTR3A

Biological processes related to Fibromyalgia according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1behavioral response to painGO:04826610.6TACR1, P2RX3, TSPO
2sperm ejaculationGO:04271310.6SLC6A4, TACR1
3response to drugGO:04249310.6TSPO, SLC6A4, CRH, HTR2A, COMT
4response to hypoxiaGO:00166610.5TRH, P2RX3, SLC6A4, SERPINA1
5response to estradiol stimulusGO:03235510.5TACR1, SLC6A4, SERPINA1
6synaptic transmissionGO:00726810.5PNOC, GRIN2D, CRH, NPY, HTR3B, HTR2A
7positive regulation of action potentialGO:04576010.5TACR1, NPS
8positive regulation of synaptic transmission, GABAergicGO:03223010.5NPS, TACR1
9response to painGO:04826510.4CRH, COMT
10response to ethanolGO:04547110.4TACR1, TRH, CRH
11serotonin receptor signaling pathwayGO:00721010.3HTR3A, HTR2A
12neuropeptide signaling pathwayGO:00721810.1PNOC, NPY, NPS

Molecular functions related to Fibromyalgia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1serotonin bindingGO:05137810.4HTR2A, HTR3A
2neuropeptide hormone activityGO:00518410.4PNOC, TRH, CRH, NPY
3serotonin receptor activityGO:00499310.3HTR3A, HTR2A, HTR3B
4serotonin-activated cation-selective channel activityGO:00523210.1HTR3B, HTR3A

Products for genes affiliated with Fibromyalgia

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  • Lysates
  • Antibodies

Sources for Fibromyalgia

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet