MCID: FBR047
MIFTS: 42

Fibromyalgia malady

Summaries for Fibromyalgia

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MedlinePlus:32 Fibromyalgia is a disorder that causes muscle pain and fatigue. people with fibromyalgia have "tender points" on the body. tender points are specific places on the neck, shoulders, back, hips, arms, and legs. these points hurt when pressure is put on them. people with fibromyalgia may also have other symptoms, such as trouble sleeping morning stiffness headaches painful menstrual periods tingling or numbness in hands and feet problems with thinking and memory (sometimes called "fibro fog") no one knows what causes fibromyalgia. anyone can get it, but it is most common in middle-aged women. people with rheumatoid arthritis and other autoimmune diseases are particularly likely to develop fibromyalgia. there is no cure for fibromyalgia, but medicine can help you manage your symptoms. getting enough sleep, exercising, and eating well may also help. nih: national institute of arthritis and musculoskeletal and skin diseases

MalaCards based summary: Fibromyalgia is related to chronic fatigue syndrome and irritable bowel syndrome. An important gene associated with Fibromyalgia is HTR3A (5-hydroxytryptamine (serotonin) receptor 3A, ionotropic), and among its related pathways are Ligand-gated ion channel transport and SIDS Susceptibility Pathways. The compounds ly 53857 and buspirone have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and brain, and related mouse phenotypes are homeostasis/metabolism and behavior/neurological.

CDC:3 NOTE: for the following sections using data based on ICD9-CM codes, there is no specific single code for fibromyalgia. According to coding rules, fibromyalgia is coded to 729.1 which is labeled “Myositis and Myalgia, unspecified” and can include other conditions. Thus, numbers based on ICDM9-CM code 729.1 for mortality, ambulatory care and hospitalizations may be overestimates.

Wikipedia:63 Fibromyalgia (FM or FMS) is characterised by chronic widespread pain and a heightened and painful... more...

Aliases & Classifications for Fibromyalgia

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Sources:
11DISEASES, 43Novoseek, 32MedlinePlus, 3CDC, 60UMLS, 25ICD10
See all sources

Fibromyalgia, Aliases & Descriptions:

Name: Fibromyalgia 11 43 32 3 60


Classifications:



External Ids:

ICD1025 M79.7

Related Diseases for Fibromyalgia

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Diseases related to Fibromyalgia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 177)
idRelated DiseaseScoreTop Affiliating Genes
1chronic fatigue syndrome31.4CRH, SLC6A4
2irritable bowel syndrome30.6HTR3A, CRH, SLC6A4
3serotonin syndrome30.6HTR2A, HTR3A
4rheumatoid arthritis30.5SERPINA1, CRH, MEFV, TSPO
5hepatitis30.4SERPINA1, COMT
6migraine30.3SLC6A4, HTR2A, COMT, HTR3A
7obesity30.3HTR2A, NPY, CRH, COMT
8anxiety disorder30.2SLC6A4, CRH, HTR3A
9central nervous system disease30.0HTR2A, SLC6A4
10dementia29.9HTR2A, TSPO, COMT, HTR3A
11hypoglycemia29.7CRH, NPY, HTR2A, COMT
12eating disorder29.5HTR2A, COMT, CRH, NPY, SLC6A4, HTR3A
13mood disorder29.5SLC6A4, CRH, NPY, HTR3A, COMT, HTR2A
14myofascial pain syndrome10.6
15arthritis10.5
16blindness10.5
17melancholia10.5CRH
18neuropathy10.4
19alcoholic psychosis10.4SLC6A4
20premature ejaculation10.4SLC6A4
21amnestic disorder10.3TSPO, HTR3A
22chronic pain10.3
23heart valve disease10.3HTR2A, HTR3A
24alexithymia10.3
25autonomic dysfunction10.3
26dysautonomia10.3
27schizophrenia10.3HTR2A, COMT
28multiple chemical sensitivity10.3
29sleep disorder10.3
30back pain10.3
31generalized anxiety disorder10.2TSPO, SLC6A4
32eosinophilia-myalgia syndrome10.2
33eosinophilia10.2
34rheumatic disease10.2
35narcolepsy10.2HTR2A, COMT
36cocaine abuse10.2HTR3A, SLC6A4
37endogenous depression10.2CRH, SLC6A4
38major depressive disorder and accelerated response to antidepressant drug treatment10.2SLC6A4, CRH
39antisocial personality disorder10.2HTR2A, SLC6A4
40pain agnosia10.2HTR3A, CRH
41galactosemia10.2SERPINA1, TSPO
42constipation10.2HTR3A, SLC6A4
43substance dependence10.2COMT, SLC6A4
44psoriatic arthritis10.2
45pain disorder10.2
46carcinoid syndrome10.2HTR3A, CRH, HTR2A
47conduct disorder10.2SLC6A4, COMT
48substance abuse10.2CRH, SLC6A4
49alcohol abuse10.2SLC6A4, COMT
50temporal lobe epilepsy10.1TSPO, NPY

Graphical network of the top 20 diseases related to Fibromyalgia:



Diseases related to fibromyalgia

Symptoms for Fibromyalgia

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Drugs & Therapeutics for Fibromyalgia

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Drug clinical trials:

Search ClinicalTrials for Fibromyalgia

Search NIH Clinical Center for Fibromyalgia

Genetic Tests for Fibromyalgia

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Anatomical Context for Fibromyalgia

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MalaCards organs/tissues related to Fibromyalgia:

31
Skin, Testes, Brain, Pituitary, Cortex, Heart, Bone, Thyroid, Monocytes, Breast, Endothelial, Neutrophil, Eye, Skeletal muscle, Lung, T cells, Cingulate cortex

Animal Models for Fibromyalgia or affiliated genes

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MGI Mouse Phenotypes related to Fibromyalgia:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053767.8HTR3A, COMT, CRH, NPY, SLC6A4, MEFV
2MP:00053867.6SLC6A4, NPY, CRH, COMT, HTR3A, HTR2A

Publications for Fibromyalgia

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Articles related to Fibromyalgia:

(show top 50)    (show all 789)
idTitleAuthorsYear
1
Intra- and Inter-Patient Symptom Variability in Fibromyalgia: Results of a 90-Day Assessment. (25408116)
2014
2
Suicidal Ideation in Patients with Fibromyalgia: A Cross-Sectional Study. (24433278)
2014
3
Improving the primary care physicians' decision making for fibromyalgia in clinical practice: development and validation of the Fibromyalgia Detection (FibroDetectAr) screening tool. (25341959)
2014
4
The role of vitamin D in pathophysiology and treatment of fibromyalgia. (23801008)
2013
5
Brain correlates of cognitive inhibition in fibromyalgia: emotional intrusion of symptom-related words. (23557844)
2013
6
Meanings of feeling well for women with fibromyalgia. (23530542)
2013
7
Posttraumatic stress disorder in fibromyalgia syndrome: prevalence, temporal relationship between posttraumatic stress and fibromyalgia symptoms, and impact on clinical outcome. (23685006)
2013
8
Research to encourage exercise for fibromyalgia (REEF): use of motivational interviewing, outcomes from a randomized-controlled trial. (23042474)
2013
9
Validation of a Spanish version of the Revised Fibromyalgia Impact Questionnaire (FIQR). (23915386)
2013
10
Acylated ghrelin: a potential marker for fibromyalgia? (23475812)
2013
11
Trapezius activity of fibromyalgia patients is enhanced in stressful situations, but is similar to healthy controls in a quiet naturalistic setting: a case-control study. (23506457)
2013
12
Factors promoting sustainable work in women with fibromyalgia. (23336119)
2013
13
Prevalence of fibromyalgia in vasovagal syncope. (23519175)
2013
14
Trajectory of change in pain, depression, and physical functioning after physical activity adoption in fibromyalgia. (24165860)
2013
15
Cognitive impairment in fibromyalgia. (23709236)
2013
16
Fibromyalgia syndrome--novel therapeutic targets. (23742873)
2013
17
Feasibility of Interactive Technology for Symptom Monitoring in Patients with Fibromyalgia. (23434124)
2013
18
Extension trial of qigong for fibromyalgia: a quantitative and qualitative study. (24069054)
2013
19
Validation and psychometric properties of the Spanish version of the Quality of Life Scale (QOLS) in patients with fibromyalgia. (24097208)
2013
20
Classification and Clinical Diagnosis of Fibromyalgia Syndrome: Recommendations of Recent Evidence-Based Interdisciplinary Guidelines. (24379886)
2013
21
Effect of moderate to vigorous physical activity on long-term clinical outcomes and pain severity in fibromyalgia. (23401486)
2013
22
Association between fibromyalgia syndrome and polymorphism of the IL-4 gene in a Turkish population. (23644020)
2013
23
Longitudinal observation of treatment patterns and outcomes for patients with fibromyalgia: 12-month findings from the reflections study. (23758985)
2013
24
Quality of life and emotional functioning in youth with chronic migraine and juvenile fibromyalgia. (23446072)
2013
25
Fibromyalgia research indicates it is a spectrum disorder and not a disease. (24151889)
2013
26
Association of fibromyalgia with altered skeletal muscle characteristics which may contribute to postexertional fatigue in postmenopausal women. (23124535)
2013
27
Self-reported sensory descriptors are associated with quantitative sensory testing parameters in patients with cervical radiculopathy, but not in patients with fibromyalgia. (23108871)
2013
28
Increased brain responses during subjectively-matched mechanical pain stimulation in fibromyalgia patients as evidenced by MEG. (23121899)
2013
29
Effects of shiatsu in the management of fibromyalgia symptoms: a controlled pilot study. (23830713)
2013
30
Complementary therapies for fibromyalgia syndrome -- a rational approach. (23801007)
2013
31
Work-related physical trauma and fibromyalgia. (23996999)
2013
32
Bone mass and vitamin D levels in women with a diagnosis of fibromyalgia. (24008400)
2013
33
Fear-learning deficits in fibromyalgia: precursor or consequence? (24006368)
2013
34
A patient and physician survey of fibromyalgia across Latin America and Europe. (23767857)
2013
35
Hyperexcitable C nociceptors in fibromyalgia. (24243538)
2013
36
Survey Criteria for Fibromyalgia Independently Predict Increased Postoperative Opioid Consumption after Lower-extremity Joint Arthroplasty: A Prospective, Observational Cohort Study. (24343289)
2013
37
A 3-year, open-label, flexible-dosing study of milnacipran for the treatment of fibromyalgia. (23446068)
2013
38
Juvenile fibromyalgia: current status of research and future developments. (24275966)
2013
39
Internet-Delivered Acceptance and Values-Based Exposure Treatment for Fibromyalgia: A Pilot Study. (24215278)
2013
40
Effects of a one week multidisciplinary inpatient self-management programme for patients with fibromyalgia: a randomised controlled trial. (23013162)
2012
41
Entheseal power Doppler ultrasonography: a comparison of psoriatic arthritis and fibromyalgia. (22751587)
2012
42
Sodium oxybate: not authorised for fibromyalgia. (23373093)
2012
43
Influence of the interaction between environmental quality and T102C SNP in the HTR2A gene on fibromyalgia susceptibility. (22124593)
2011
44
Pilot study to assess the frequency of fibromyalgia, depression, and sleep disorders in patients with granulomatosis with polyangiitis (Wegener's). (21337530)
2011
45
Missense mutations in the MEFV gene are associated with fibromyalgia syndrome and correlate with elevated IL-1beta plasma levels. (20041150)
2009
46
Alteration of serotonin transporter density and activity in fibromyalgia. (16790074)
2006
47
Neuroendocrine and hormonal perturbations and relations to the serotonergic system in fibromyalgia patients. (11028824)
2000
48
Plasma levels on nociceptin in female fibromyalgia syndrome patients. (10025089)
1998
49
Secretory pattern of GH, TSH, thyroid hormones, ACTH, cortisol, FSH, and LH in patients with fibromyalgia syndrome following systemic injection of the relevant hypothalamic-releasing hormones. (10025090)
1998
50
Possible concomitant fibromyalgia in systemic lupus erythematosus patients with overt central nervous system disease but with cognitive deficits: comment on the article by Kozora et al. (9259439)
1997

Variations for Fibromyalgia

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Expression for genes affiliated with Fibromyalgia

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Search GEO for disease gene expression data for Fibromyalgia.

Pathways for genes affiliated with Fibromyalgia

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Compounds for genes affiliated with Fibromyalgia

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Compounds related to Fibromyalgia according to GeneCards Suite gene sharing:

(show top 50)    (show all 175)
idCompoundScoreTop Affiliating Genes
1ly 53857439.8HTR2A, HTR3A
2buspirone43 28 1211.8HTR3A, TSPO, HTR2A
3mdl 100907439.8HTR2A, HTR3A
4benzodiazepine439.8HTR3A, CRH, TSPO
5mdl 72222439.7HTR2A, HTR3A
6allopregnanolone439.6TSPO, CRH, NPY
75,7-dihydroxytryptamine439.6SLC6A4, HTR2A
88-hydroxy-2-(di-n-propylamino)tetralin439.6SLC6A4, HTR3A, HTR2A
9m-chlorophenylpiperazine439.5SLC6A4, HTR3A, HTR2A
10mcpp439.5SLC6A4, HTR3A, HTR2A
11pindolol43 28 1211.5HTR3A, HTR2A, SLC6A4
12propranolol43 28 49 24 1213.5CRH, TSPO, COMT, HTR3A
13tegaserod43 28 1211.5HTR2A, HTR3A, SLC6A4
14sertraline43 28 49 24 1213.5HTR3A, CRH, SLC6A4
15alpha methyl 5 hydroxytryptamine439.5HTR2A, HTR3A
16nefazodone43 49 1211.5HTR3A, HTR2A, SLC6A4
175-hydroxyindoleacetic acid43 2410.4HTR3A, SLC6A4, CRH
18mianserin43 28 1211.4HTR2A, HTR3A, SLC6A4
19homovanillic acid43 2410.4COMT, SLC6A4, CRH
20ketanserin43 2810.4SLC6A4, HTR2A, HTR3A
21maoa439.4SLC6A4, HTR2A, COMT
22ondansetron49 43 24 1212.3HTR3A, HTR2A, SLC6A4
23spec-t439.3SLC6A4, CRH, TSPO
24yohimbine43 2 28 1212.3HTR2A, HTR3A, NPY, CRH
255-hydroxytryptophan439.2HTR3A, HTR2A, CRH, SLC6A4
26mirtazapine43 49 1211.2HTR2A, HTR3A, CRH, SLC6A4
27fluoxetine43 49 28 1212.2CRH, HTR3A, HTR2A, SLC6A4
28venlafaxine43 49 24 1212.2HTR2A, HTR3A, COMT, SLC6A4
29citalopram43 49 24 1212.2SLC6A4, HTR2A, HTR3A, CRH
30paroxetine43 49 28 1212.2SLC6A4, COMT, HTR3A, HTR2A
31risperidone43 49 28 59 24 1214.2HTR2A, SLC6A4, HTR3A, COMT
32olanzapine43 49 28 24 1213.1HTR3A, HTR2A, SLC6A4, COMT
33amitriptyline43 28 49 1212.1HTR3A, HTR2A, SLC6A4
34bupropion49 43 24 1212.1COMT, NPY, SLC6A4
35clozapine43 28 49 1212.1HTR2A, HTR3A, COMT, SLC6A4
36mhpg439.0NPY, CRH, COMT, SLC6A4
37opiate439.0SLC6A4, NPY, TSPO, CRH
38corticosterone43 59 2411.0NPY, SLC6A4, TSPO, CRH
39clomipramine43 49 1210.9SLC6A4, TSPO, HTR2A, HTR3A, CRH
40fluvoxamine43 49 1210.9SLC6A4, COMT, HTR3A, HTR2A, TSPO
41gaba438.8NPY, HTR3A, TSPO, SLC6A4, CRH
42Serotonin248.8SLC6A4, HTR3A, HTR2A, HTR3B
43haloperidol43 49 28 2 1212.7SLC6A4, NPY, HTR3A, HTR2A, TSPO
44fenfluramine43 28 1210.7CRH, NPY, SLC6A4, HTR3A, HTR2A
45cocaine43 129.7CRH, SLC6A4, NPY, COMT, TSPO
46nicotine43 28 49 1211.7TSPO, SLC6A4, NPY, CRH, COMT
47estrogen438.1COMT, CRH, SLC6A4, NPY, TSPO, SERPINA1
48norepinephrine43 24 1210.0SLC6A4, TSPO, HTR2A, HTR3A, COMT, CRH
49dopamine43 28 24 1211.0TSPO, HTR2A, HTR3A, COMT, CRH, NPY
505-hydroxytryptamine437.2SLC6A4, TSPO, HTR3B, HTR2A, HTR3A, COMT

GO Terms for genes affiliated with Fibromyalgia

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Cellular components related to Fibromyalgia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1integral component of plasma membraneGO:00058878.3SLC6A4, HTR3A, HTR2A, HTR3B

Biological processes related to Fibromyalgia according to GeneCards Suite gene sharing:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1serotonin receptor signaling pathwayGO:00072109.9HTR2A, HTR3A
2adrenal gland developmentGO:00303259.9CRH, TSPO
3response to painGO:00482659.9CRH, COMT
4digestionGO:00075869.7NPY, HTR3A
5feeding behaviorGO:00076319.6CRH, NPY
6cation transportGO:00068129.3HTR3A, HTR3B
7memoryGO:00076139.1SLC6A4, HTR2A
8response to drugGO:00424938.6SLC6A4, CRH, COMT, HTR2A, TSPO
9synaptic transmissionGO:00072687.6NPY, TSPO, HTR3B, HTR2A, HTR3A, COMT

Molecular functions related to Fibromyalgia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1neuropeptide hormone activityGO:00051849.6NPY, CRH
2serotonin bindingGO:00513789.5HTR3A, HTR2A
3serotonin-activated cation-selective channel activityGO:00052329.3HTR3A, HTR3B
4serotonin receptor activityGO:00049938.9HTR3A, HTR2A, HTR3B

Products for genes affiliated with Fibromyalgia

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Sources for Fibromyalgia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet