MCID: FBR047
MIFTS: 49

Fibromyalgia malady

Summaries for Fibromyalgia

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35MedlinePlus, 4CDC, 66Wikipedia, 34MalaCards
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MedlinePlus:35 Fibromyalgia is a disorder that causes muscle pain and fatigue. people with fibromyalgia have "tender points" on the body. tender points are specific places on the neck, shoulders, back, hips, arms, and legs. these points hurt when pressure is put on them. people with fibromyalgia may also have other symptoms, such as trouble sleeping morning stiffness headaches painful menstrual periods tingling or numbness in hands and feet problems with thinking and memory (sometimes called "fibro fog") no one knows what causes fibromyalgia. anyone can get it, but it is most common in middle-aged women. people with rheumatoid arthritis and other autoimmune diseases are particularly likely to develop fibromyalgia. there is no cure for fibromyalgia, but medicine can help you manage your symptoms. getting enough sleep, exercising, and eating well may also help. nih: national institute of arthritis and musculoskeletal and skin diseases

MalaCards: Fibromyalgia is related to chronic fatigue syndrome and rheumatoid arthritis. An important gene associated with Fibromyalgia is HTR3A (5-hydroxytryptamine (serotonin) receptor 3A, ionotropic), and among its related pathways are Ligand-gated ion channel transport and SIDS Susceptibility Pathways. The compounds ly 53857 and buspirone have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and brain, and related mouse phenotypes are homeostasis/metabolism and behavior/neurological.

CDC:4 NOTE: for the following sections using data based on ICD9-CM codes, there is no specific single code for fibromyalgia. According to coding rules, fibromyalgia is coded to 729.1 which is labeled “Myositis and Myalgia, unspecified” and can include other conditions. Thus, numbers based on ICDM9-CM code 729.1 for mortality, ambulatory care and hospitalizations may be overestimates.

Wikipedia:66 Fibromyalgia (FM or FMS) is characterised by chronic widespread pain and allodynia (a heightened and... more...

Aliases & Classifications for Fibromyalgia

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Sources:
11DISEASES, 46Novoseek, 35MedlinePlus, 63UMLS, 26ICD10
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Related Diseases for Fibromyalgia

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18GeneCards, 19GeneDecks
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Diseases related to Fibromyalgia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 175)
idRelated DiseaseScoreTop Affiliating Genes
1chronic fatigue syndrome31.1CRH, SLC6A4
2rheumatoid arthritis30.6SERPINA1, CRH, MEFV, TSPO
3migraine30.4SLC6A4, HTR2A, COMT, HTR3A
4obesity30.3HTR2A, NPY, CRH, COMT
5irritable bowel syndrome30.3HTR3A, CRH, SLC6A4
6serotonin syndrome30.1HTR2A, HTR3A
7hepatitis30.1SERPINA1, COMT
8mood disorder30.0SLC6A4, CRH, NPY, HTR3A, COMT, HTR2A
9memory impairment29.9TSPO, HTR2A
10eating disorder29.9HTR2A, COMT, CRH, NPY, SLC6A4, HTR3A
11anxiety disorder29.8SLC6A4, CRH, HTR3A
12central nervous system disease29.8HTR2A, SLC6A4
13dementia29.8HTR2A, TSPO, COMT, HTR3A
14hypoglycemia29.8CRH, NPY, HTR2A, COMT
15paine syndrome10.6
16myofascial pain syndrome10.6
17blindness10.5
18arthritis10.5
19neuropathy10.3
20alexithymia10.3
21dysautonomia10.3
22multiple chemical sensitivity10.3
23autonomic dysfunction10.3
24back pain10.3
25chronic pain10.3
26eosinophilia-myalgia syndrome10.2
27eosinophilia10.2
28sleep disorder10.2
29rheumatic disease10.2
30psoriatic arthritis10.2
31melancholia10.1CRH
32pain disorder10.1
33cervicitis10.1
34complex regional pain syndrome10.1
35diabetic neuropathy10.1
36polyneuropathy10.1
37thyroiditis10.1
38headache10.1
39alcoholic psychosis10.1SLC6A4
40premature ejaculation10.1SLC6A4
41amnestic disorder10.1TSPO, HTR3A
42heart valve disease10.1HTR2A, HTR3A
43schizophrenia10.1HTR2A, COMT
44generalized anxiety disorder10.1TSPO, SLC6A4
45narcolepsy10.1HTR2A, COMT
46cocaine abuse10.1HTR3A, SLC6A4
47endogenous depression10.1SLC6A4, CRH
48antisocial personality disorder10.0HTR2A, SLC6A4
49pain agnosia10.0HTR3A, CRH
50galactosemia10.0SERPINA1, TSPO

Graphical network of the top 20 diseases related to Fibromyalgia:



Diseases related to fibromyalgia

Symptoms for Fibromyalgia

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Drugs & Therapeutics for Fibromyalgia

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Fibromyalgia

Drug clinical trials:

Search ClinicalTrials for Fibromyalgia

Search NIH Clinical Center for Fibromyalgia

Search CenterWatch for Fibromyalgia

Genetic Tests for Fibromyalgia

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Anatomical Context for Fibromyalgia

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Sources:
34MalaCards
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MalaCards organs/tissues related to Fibromyalgia:

34
Skin, Testes, Brain, Pituitary, Heart, Cortex, Monocytes, Thyroid, Bone, Breast, Endothelial, Skeletal muscle, Eye, T cells, Lung, Cingulate cortex

Animal Models for Fibromyalgia or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Fibromyalgia:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053767.8HTR3A, COMT, CRH, NPY, SLC6A4, MEFV
2MP:00053867.6SLC6A4, NPY, CRH, COMT, HTR3A, HTR2A

Publications for Fibromyalgia

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53PubMed
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Articles related to Fibromyalgia:

(show top 50)    (show all 724)
idTitleAuthorsYear
1
Suicidal Ideation in Patients with Fibromyalgia: A Cross-Sectional Study. (24433278)
2014
2
The role of vitamin D in pathophysiology and treatment of fibromyalgia. (23801008)
2013
3
Brain correlates of cognitive inhibition in fibromyalgia: emotional intrusion of symptom-related words. (23557844)
2013
4
Meanings of feeling well for women with fibromyalgia. (23530542)
2013
5
Posttraumatic stress disorder in fibromyalgia syndrome: prevalence, temporal relationship between posttraumatic stress and fibromyalgia symptoms, and impact on clinical outcome. (23685006)
2013
6
Research to encourage exercise for fibromyalgia (REEF): use of motivational interviewing, outcomes from a randomized-controlled trial. (23042474)
2013
7
Validation of a Spanish version of the Revised Fibromyalgia Impact Questionnaire (FIQR). (23915386)
2013
8
Acylated ghrelin: a potential marker for fibromyalgia? (23475812)
2013
9
Trapezius activity of fibromyalgia patients is enhanced in stressful situations, but is similar to healthy controls in a quiet naturalistic setting: a case-control study. (23506457)
2013
10
Factors promoting sustainable work in women with fibromyalgia. (23336119)
2013
11
Prevalence of fibromyalgia in vasovagal syncope. (23519175)
2013
12
Trajectory of change in pain, depression, and physical functioning after physical activity adoption in fibromyalgia. (24165860)
2013
13
Serum level of brain-derived neurotrophic factor in fibromyalgia syndrome correlates with depression but not anxiety. (23318672)
2013
14
Cognitive impairment in fibromyalgia. (23709236)
2013
15
Fibromyalgia syndrome--novel therapeutic targets. (23742873)
2013
16
Feasibility of Interactive Technology for Symptom Monitoring in Patients with Fibromyalgia. (23434124)
2013
17
Extension trial of qigong for fibromyalgia: a quantitative and qualitative study. (24069054)
2013
18
Validation and psychometric properties of the Spanish version of the Quality of Life Scale (QOLS) in patients with fibromyalgia. (24097208)
2013
19
Classification and Clinical Diagnosis of Fibromyalgia Syndrome: Recommendations of Recent Evidence-Based Interdisciplinary Guidelines. (24379886)
2013
20
Effect of moderate to vigorous physical activity on long-term clinical outcomes and pain severity in fibromyalgia. (23401486)
2013
21
Association between fibromyalgia syndrome and polymorphism of the IL-4 gene in a Turkish population. (23644020)
2013
22
Longitudinal observation of treatment patterns and outcomes for patients with fibromyalgia: 12-month findings from the reflections study. (23758985)
2013
23
Quality of life and emotional functioning in youth with chronic migraine and juvenile fibromyalgia. (23446072)
2013
24
Fibromyalgia research indicates it is a spectrum disorder and not a disease. (24151889)
2013
25
Association of fibromyalgia with altered skeletal muscle characteristics which may contribute to postexertional fatigue in postmenopausal women. (23124535)
2013
26
Self-reported sensory descriptors are associated with quantitative sensory testing parameters in patients with cervical radiculopathy, but not in patients with fibromyalgia. (23108871)
2013
27
Increased brain responses during subjectively-matched mechanical pain stimulation in fibromyalgia patients as evidenced by MEG. (23121899)
2013
28
Effects of shiatsu in the management of fibromyalgia symptoms: a controlled pilot study. (23830713)
2013
29
Complementary therapies for fibromyalgia syndrome -- a rational approach. (23801007)
2013
30
Work-related physical trauma and fibromyalgia. (23996999)
2013
31
Bone mass and vitamin D levels in women with a diagnosis of fibromyalgia. (24008400)
2013
32
Fear-learning deficits in fibromyalgia: precursor or consequence? (24006368)
2013
33
A patient and physician survey of fibromyalgia across Latin America and Europe. (23767857)
2013
34
Hyperexcitable C nociceptors in fibromyalgia. (24243538)
2013
35
Survey Criteria for Fibromyalgia Independently Predict Increased Postoperative Opioid Consumption after Lower-extremity Joint Arthroplasty: A Prospective, Observational Cohort Study. (24343289)
2013
36
A 3-year, open-label, flexible-dosing study of milnacipran for the treatment of fibromyalgia. (23446068)
2013
37
Internet-Delivered Acceptance and Values-Based Exposure Treatment for Fibromyalgia: A Pilot Study. (24215278)
2013
38
Do patients with fibromyalgia show abnormal neural responses to the observation of pain in others? (23419861)
2013
39
Effects of a one week multidisciplinary inpatient self-management programme for patients with fibromyalgia: a randomised controlled trial. (23013162)
2012
40
Entheseal power Doppler ultrasonography: a comparison of psoriatic arthritis and fibromyalgia. (22751587)
2012
41
Sodium oxybate: not authorised for fibromyalgia. (23373093)
2012
42
Influence of the interaction between environmental quality and T102C SNP in the HTR2A gene on fibromyalgia susceptibility. (22124593)
2011
43
Pilot study to assess the frequency of fibromyalgia, depression, and sleep disorders in patients with granulomatosis with polyangiitis (Wegener's). (21337530)
2011
44
Missense mutations in the MEFV gene are associated with fibromyalgia syndrome and correlate with elevated IL-1beta plasma levels. (20041150)
2009
45
Alteration of serotonin transporter density and activity in fibromyalgia. (16790074)
2006
46
Neuroendocrine and hormonal perturbations and relations to the serotonergic system in fibromyalgia patients. (11028824)
2000
47
Plasma levels on nociceptin in female fibromyalgia syndrome patients. (10025089)
1998
48
Secretory pattern of GH, TSH, thyroid hormones, ACTH, cortisol, FSH, and LH in patients with fibromyalgia syndrome following systemic injection of the relevant hypothalamic-releasing hormones. (10025090)
1998
49
Possible concomitant fibromyalgia in systemic lupus erythematosus patients with overt central nervous system disease but with cognitive deficits: comment on the article by Kozora et al. (9259439)
1997
50
Hypothalamic-pituitary-adrenal axis perturbations in patients with fibromyalgia. (7980669)
1994

Variations for Fibromyalgia

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Expression for genes affiliated with Fibromyalgia

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Fibromyalgia

Search GEO for disease gene expression data for Fibromyalgia.

Pathways for genes affiliated with Fibromyalgia

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Sources:
51PathCards, 56Reactome, 39NCBI BioSystems Database, 52PharmGKB, 31KEGG
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Compounds for genes affiliated with Fibromyalgia

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Sources:
46Novoseek, 30IUPHAR, 12DrugBank, 52PharmGKB, 25HMDB, 3BitterDB, 62Tocris Bioscience
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Compounds related to Fibromyalgia according to GeneCards/GeneDecks:

(show top 50)    (show all 175)
idCompoundScoreTop Affiliating Genes
1ly 53857469.8HTR2A, HTR3A
2buspirone46 30 1211.8HTR3A, TSPO, HTR2A
3mdl 100907469.8HTR2A, HTR3A
4benzodiazepine469.8HTR3A, CRH, TSPO
5mdl 72222469.7HTR2A, HTR3A
6allopregnanolone469.6TSPO, CRH, NPY
75,7-dihydroxytryptamine469.6SLC6A4, HTR2A
88-hydroxy-2-(di-n-propylamino)tetralin469.6SLC6A4, HTR3A, HTR2A
9m-chlorophenylpiperazine469.5SLC6A4, HTR3A, HTR2A
10mcpp469.5SLC6A4, HTR3A, HTR2A
11pindolol46 30 1211.5HTR3A, HTR2A, SLC6A4
12propranolol46 30 52 25 1213.5CRH, TSPO, COMT, HTR3A
13tegaserod46 30 1211.5HTR2A, HTR3A, SLC6A4
14sertraline46 30 52 25 1213.5HTR3A, CRH, SLC6A4
15alpha methyl 5 hydroxytryptamine469.5HTR2A, HTR3A
16nefazodone46 52 1211.5HTR3A, HTR2A, SLC6A4
175-hydroxyindoleacetic acid46 2510.4HTR3A, SLC6A4, CRH
18mianserin46 30 1211.4HTR2A, HTR3A, SLC6A4
19homovanillic acid46 2510.4COMT, SLC6A4, CRH
20ketanserin46 3010.4SLC6A4, HTR2A, HTR3A
21maoa469.4SLC6A4, HTR2A, COMT
22ondansetron52 46 25 1212.3HTR3A, HTR2A, SLC6A4
23spec-t469.3SLC6A4, CRH, TSPO
24yohimbine46 3 30 1212.3HTR2A, HTR3A, NPY, CRH
255-hydroxytryptophan469.2HTR3A, HTR2A, CRH, SLC6A4
26mirtazapine46 52 1211.2HTR2A, HTR3A, CRH, SLC6A4
27fluoxetine46 52 30 1212.2CRH, HTR3A, HTR2A, SLC6A4
28venlafaxine46 52 25 1212.2HTR2A, HTR3A, COMT, SLC6A4
29citalopram46 52 25 1212.2SLC6A4, HTR2A, HTR3A, CRH
30paroxetine46 52 30 1212.2SLC6A4, COMT, HTR3A, HTR2A
31risperidone46 52 30 62 25 1214.2HTR2A, SLC6A4, HTR3A, COMT
32olanzapine46 52 30 25 1213.1HTR3A, HTR2A, SLC6A4, COMT
33amitriptyline46 30 52 1212.1HTR3A, HTR2A, SLC6A4
34bupropion52 46 25 1212.1COMT, NPY, SLC6A4
35clozapine46 30 52 1212.1HTR2A, HTR3A, COMT, SLC6A4
36mhpg469.0NPY, CRH, COMT, SLC6A4
37opiate469.0SLC6A4, NPY, TSPO, CRH
38corticosterone46 62 2511.0NPY, SLC6A4, TSPO, CRH
39clomipramine46 52 1210.9SLC6A4, TSPO, HTR2A, HTR3A, CRH
40fluvoxamine46 52 1210.9SLC6A4, COMT, HTR3A, HTR2A, TSPO
41gaba468.8NPY, HTR3A, TSPO, SLC6A4, CRH
42Serotonin258.8SLC6A4, HTR3A, HTR2A, HTR3B
43haloperidol46 52 30 3 1212.7SLC6A4, NPY, HTR3A, HTR2A, TSPO
44fenfluramine46 30 1210.7CRH, NPY, SLC6A4, HTR3A, HTR2A
45cocaine46 129.7CRH, SLC6A4, NPY, COMT, TSPO
46nicotine46 30 52 1211.7TSPO, SLC6A4, NPY, CRH, COMT
47estrogen468.1COMT, CRH, SLC6A4, NPY, TSPO, SERPINA1
48norepinephrine46 25 1210.0SLC6A4, TSPO, HTR2A, HTR3A, COMT, CRH
49dopamine46 30 25 1211.0TSPO, HTR2A, HTR3A, COMT, CRH, NPY
505-hydroxytryptamine467.2SLC6A4, TSPO, HTR3B, HTR2A, HTR3A, COMT

GO Terms for genes affiliated with Fibromyalgia

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17Gene Ontology
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Cellular components related to Fibromyalgia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral component of plasma membraneGO:0058878.3SLC6A4, HTR3A, HTR2A, HTR3B

Biological processes related to Fibromyalgia according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1serotonin receptor signaling pathwayGO:0072109.9HTR2A, HTR3A
2adrenal gland developmentGO:0303259.9CRH, TSPO
3response to painGO:0482659.9CRH, COMT
4digestionGO:0075869.7HTR3A, NPY
5feeding behaviorGO:0076319.6NPY, CRH
6cation transportGO:0068129.3HTR3A, HTR3B
7memoryGO:0076139.1HTR2A, SLC6A4
8response to drugGO:0424938.6HTR2A, COMT, CRH, TSPO, SLC6A4
9synaptic transmissionGO:0072687.6TSPO, HTR3B, HTR2A, HTR3A, COMT, CRH

Molecular functions related to Fibromyalgia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuropeptide hormone activityGO:0051849.6NPY, CRH
2serotonin bindingGO:0513789.5HTR3A, HTR2A
3serotonin-activated cation-selective channel activityGO:0052329.3HTR3A, HTR3B
4serotonin receptor activityGO:0049938.9HTR3A, HTR2A, HTR3B

Products for genes affiliated with Fibromyalgia

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  • Antibodies
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Sources for Fibromyalgia

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet