MCID: FBR047
MIFTS: 38

Fibromyalgia malady

Summaries for Fibromyalgia

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33MedlinePlus, 3CDC, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Fibromyalgia is a disorder that causes muscle pain and fatigue. people with fibromyalgia have "tender points" on the body. tender points are specific places on the neck, shoulders, back, hips, arms, and legs. these points hurt when pressure is put on them. people with fibromyalgia may also have other symptoms, such as trouble sleeping morning stiffness headaches painful menstrual periods tingling or numbness in hands and feet problems with thinking and memory (sometimes called "fibro fog") no one knows what causes fibromyalgia. anyone can get it, but it is most common in middle-aged women. people with rheumatoid arthritis and other autoimmune diseases are particularly likely to develop fibromyalgia. there is no cure for fibromyalgia, but medicine can help you manage your symptoms. getting enough sleep, exercising, and eating well may also help. nih: national institute of arthritis and musculoskeletal and skin diseases

MalaCards: Fibromyalgia is related to chronic fatigue syndrome and arthritis. An important gene associated with Fibromyalgia is HTR3A (5-hydroxytryptamine (serotonin) receptor 3A, ionotropic), and among its related pathways are Monoamine GPCRs and Selected targets of CREB1. The compounds 5-hydroxytryptophan and mhpg have been mentioned in the context of this disorder. Affiliated tissues include skin, and related mouse phenotypes are integument and behavior/neurological.

CDC:3 NOTE: for the following sections using data based on ICD9-CM codes, there is no specific single code for fibromyalgia. According to coding rules, fibromyalgia is coded to 729.1 which is labeled “Myositis and Myalgia, unspecified” and can include other conditions. Thus, numbers based on ICDM9-CM code 729.1 for mortality, ambulatory care and hospitalizations may be overestimates.

Wikipedia:63 Fibromyalgia (FM or FMS) is characterised by chronic widespread pain and allodynia (a heightened and... more...

Aliases & Classifications for Fibromyalgia

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10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 25ICD10
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Related Diseases for Fibromyalgia

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17GeneCards, 18GeneDecks
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Diseases related to Fibromyalgia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 175)
idRelated DiseaseScoreTop Affiliating Genes
1chronic fatigue syndrome31.0SUN2, SLC6A4, CRH
2arthritis30.6NPS, TACR1
3rheumatoid arthritis30.5CRH, TACR1, SERPINA1, TSPO
4migraine30.4COMT, HTR3A, HTR2A, NPS, TACR1, P2RX3
5sleep disorder30.3NPS
6obesity30.2TRH, CRH, NPY, HTR2A, COMT
7irritable bowel syndrome30.2SLC6A4, CRH, HTR3A
8thyroiditis30.1TRH
9complex regional pain syndrome30.1TACR1, NPS
10mood disorder30.1COMT, HTR3A, HTR2A, NPY, CRH, TRH
11eating disorder29.9SLC6A4
12osteoarthritis29.9NPY, TACR1, TSPO
13cystitis29.7TACR1
14anxiety disorder29.7HTR3A, CRH, SLC6A4
15bipolar disorder29.7HTR3A, HTR2A, SLC6A4
16restless legs syndrome29.7HTR3A
17dementia29.7COMT, HTR3A, HTR2A, TRH, TSPO
18hypoglycemia29.7COMT, HTR2A, NPY, CRH, TRH
19chronic interstitial cystitis29.7P2RX3, TSPO
20endometriosis29.7COMT
21myofascial pain syndrome10.6
22neuropathy10.3
23alexithymia10.3
24multiple chemical sensitivity10.2
25eosinophilia-myalgia syndrome10.2
26diabetic neuropathy10.2
27eosinophilia10.2
28psoriatic arthritis10.1
29somatization disorder10.1
30pain disorder10.1
31cervicitis10.1
32peripheral neuropathy10.1
33polyneuropathy10.1
34somatoform disorder10.1
35blindness10.0TSPO
36ischemia10.0PNOC
37borderline personality disorder10.0SLC6A4
38drug dependence10.0SLC6A4, PNOC
39substance abuse10.0SLC6A4, CRH
40cocaine dependence10.0SLC6A4
41cluster headache10.0PNOC, HTR3A
42constipation10.0SLC6A4, HTR3A
43melancholia10.0CRH, TRH
44seasonal affective disorder10.0SLC6A4, CRH, HTR2A
45social phobia10.0COMT, HTR3A, SLC6A4
46serotonin syndrome10.0HTR2A, HTR3A
47panic disorder10.0HTR3A, CRH, SLC6A4, TSPO
48amnestic disorder10.0HTR3A, PREP, TSPO
49antisocial personality disorder10.0HTR2A, SLC6A4
50obsessive-compulsive disorder10.0COMT, HTR3A, HTR2A, SLC6A4, TSPO

Graphical network of the top 20 diseases related to Fibromyalgia:



Diseases related to fibromyalgia

Clinical Features for Fibromyalgia

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Drugs & Therapeutics for Fibromyalgia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Fibromyalgia

Drug clinical trials:

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Search NIH Clinical Center for Fibromyalgia

Search CenterWatch for Fibromyalgia

Genetic Tests for Fibromyalgia

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Anatomical Context for Fibromyalgia

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32MalaCards
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MalaCards organs/tissues related to Fibromyalgia:

32
Skin

Animal Models for Fibromyalgia or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Fibromyalgia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:001077110.3CRH, GRIN2D, TACR1, P2RX3, PNOC, SLC6A4
2MP:000538610.2SLC6A4, COMT, HTR3A, HTR2A, NPY, CRH
3MP:000537610.0TRH, TACR1, P2RX3, SLC6A4, GRIN2D, PREP
4MP:00036319.9COMT, SLC6A4, P2RX3, TACR1, TRH, GRIN2D

Publications for Fibromyalgia

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Genetic Variations for Fibromyalgia

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Expression for genes affiliated with Fibromyalgia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Fibromyalgia

Search GEO for disease gene expression data for Fibromyalgia.

Pathways for genes affiliated with Fibromyalgia

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Sources:
37NCBI BioSystems Database, 49PharmGKB, 53Reactome, 12EMD Millipore, 29KEGG, 51QIAGEN
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Compounds for genes affiliated with Fibromyalgia

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 28IUPHAR, 2BitterDB, 59Tocris Bioscience
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Compounds related to Fibromyalgia according to GeneCards/GeneDecks:

(show top 50)    (show all 175)
idCompoundScoreTop Affiliating Genes
15-hydroxytryptophan4410.8HTR2A, CRH, HTR3A, SLC6A4
2mhpg4410.8NPY, CRH, SLC6A4, COMT
3citalopram49 44 11 2413.8HTR3A, HTR2A, SLC6A4, TACR1
4mirtazapine49 44 1112.8CRH, SLC6A4, HTR3A, HTR2A
58-hydroxy-2-(di-n-propylamino)tetralin4410.8HTR2A, HTR3A, SLC6A4
6alpha-aminoisobutyric acid44 1111.8NPY, CRH, PNOC
7fluvoxamine44 49 1112.8HTR3A, HTR2A, TSPO, SLC6A4
8clomipramine44 49 1112.8TSPO, HTR2A, CRH, TACR1, SLC6A4, HTR3A
9paroxetine44 49 28 1113.8SLC6A4, TACR1, HTR2A, HTR3A, COMT
10fluoxetine49 44 28 1113.8HTR3A, HTR2A, CRH, TACR1, SLC6A4
11fenfluramine28 44 1112.8HTR2A, SLC6A4, HTR3A, NPY, CRH, TRH
12m-chlorophenylpiperazine4410.8HTR3A, SLC6A4, HTR2A
13yohimbine44 28 2 1113.8HTR3A, HTR2A, CRH, NPY
14dsip4410.7NPY, TSC22D3, CRH
15mcpp4410.7SLC6A4, HTR2A, HTR3A
16opiate4410.7TSPO, CRH, SLC6A4, PNOC, NPY, TACR1
17nmda44 2811.7TSPO, TACR1, GRIN2D, COMT, PNOC
18octadecaneuropeptide4410.7TSPO, NPY, PNOC
19clozapine44 28 49 1113.7COMT, SLC6A4, TACR1, HTR3A, HTR2A
202-methyl-5-ht44 2811.7TACR1, HTR3A, HTR2A
21capsaicin44 2811.7CRH, TACR1, P2RX3, PNOC, NPY
22haloperidol44 28 2 49 1114.7NPY, SLC6A4, HTR3A, HTR2A, TRH, TACR1
23cocaine44 1111.7PNOC, TSPO, SLC6A4, CRH, TRH, COMT
24atropine44 28 1112.7PNOC, TRH, TACR1, CRH, NPY
25morphine44 49 28 1113.7TRH, TACR1, PNOC, TSPO, COMT
26risperidone28 44 49 59 11 2415.7COMT, SLC6A4, HTR2A, HTR3A
27gaba4410.7PNOC, SLC6A4, TSC22D3, NPY, TSPO, TRH
28desipramine44 49 1112.7HTR2A, CRH, TRH, SLC6A4
29acetylcholine44 49 28 11 2414.7HTR3A, TSPO, PNOC, P2RX3, TACR1, TRH
305-hydroxytryptamine4410.7TACR1, CRH, PNOC, SLC6A4, NPY, HTR3B
31guanethidine44 1111.7NPY, PNOC, TACR1
32pindolol44 28 1112.7HTR3A, HTR2A, SLC6A4
33naloxone44 49 28 1113.7CRH, TRH, PNOC, TSPO
34dopamine44 28 11 2413.6HTR3A, HTR2A, PNOC, TSPO, SLC6A4, TACR1
35histamine44 28 2412.6HTR3A, CRH, NPY, TSPO, PNOC, TACR1
36clonidine44 28 1112.6TACR1, SLC6A4, TRH, NPY
37norepinephrine44 11 2412.6CRH, NPY, HTR2A, HTR3A, COMT, TSPO
38tegaserod44 28 1112.6HTR2A, SLC6A4, HTR3A
39glutamate4410.6COMT, NPY, PREP, GRIN2D, CRH, SLC6A4
40buspirone44 28 1112.6HTR3A, TSPO, HTR2A
41arginine4410.6TSPO, HTR3B, SLC6A4, TRH, CRH, NPY
42nicotine44 49 28 1113.6TSPO, COMT, CRH, SLC6A4, NPY
43imipramine44 49 28 11 2414.5SLC6A4, TACR1, HTR2A, HTR3A
44estrogen4410.5CRH, NPY, COMT, PNOC, TRH, SERPINA1
45octreotide44 59 28 1113.5NPY, TRH, TACR1, CRH
46allopregnanolone4410.4TSPO, NPY
47nefazodone44 49 1112.4SLC6A4, HTR2A, HTR3A
48acth4410.4TSC22D3, NPY, CRH, SERPINA1, TRH
49tetrodotoxin44 59 2812.3NPY, TACR1, CRH, HTR3A
50baclofen44 1111.1NPY, TSPO, PNOC

GO Terms for genes affiliated with Fibromyalgia

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16Gene Ontology
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Cellular components related to Fibromyalgia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral to plasma membraneGO:00588710.3SLC6A4, P2RX3, TACR1, HTR3B, HTR2A, HTR3A

Biological processes related to Fibromyalgia according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1behavioral response to painGO:04826610.6TACR1, TSPO, P2RX3
2sperm ejaculationGO:04271310.6TACR1, SLC6A4
3response to drugGO:04249310.6TSPO, SLC6A4, CRH, HTR2A, COMT
4response to hypoxiaGO:00166610.5SERPINA1, SLC6A4, P2RX3, TRH
5response to estradiol stimulusGO:03235510.5SERPINA1, TACR1, SLC6A4
6synaptic transmissionGO:00726810.5COMT, HTR3A, HTR2A, HTR3B, NPY, CRH
7positive regulation of action potentialGO:04576010.5NPS, TACR1
8positive regulation of synaptic transmission, GABAergicGO:03223010.5TACR1, NPS
9response to painGO:04826510.4CRH, COMT
10response to ethanolGO:04547110.4CRH, TRH, TACR1
11serotonin receptor signaling pathwayGO:00721010.3HTR2A, HTR3A
12neuropeptide signaling pathwayGO:00721810.1NPY, NPS, PNOC

Molecular functions related to Fibromyalgia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1serotonin bindingGO:05137810.4HTR2A, HTR3A
2neuropeptide hormone activityGO:00518410.4CRH, NPY, PNOC, TRH
3serotonin receptor activityGO:00499310.3HTR3B, HTR3A, HTR2A
4serotonin-activated cation-selective channel activityGO:00523210.1HTR3B, HTR3A

Products for genes affiliated with Fibromyalgia

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Sources for Fibromyalgia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet