MCID: FBR047
MIFTS: 49

Fibromyalgia malady

Summaries for Fibromyalgia

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MedlinePlus:33 Fibromyalgia is a disorder that causes muscle pain and fatigue. people with fibromyalgia have "tender points" on the body. tender points are specific places on the neck, shoulders, back, hips, arms, and legs. these points hurt when pressure is put on them. people with fibromyalgia may also have other symptoms, such as trouble sleeping morning stiffness headaches painful menstrual periods tingling or numbness in hands and feet problems with thinking and memory (sometimes called "fibro fog") no one knows what causes fibromyalgia. anyone can get it, but it is most common in middle-aged women. people with rheumatoid arthritis and other autoimmune diseases are particularly likely to develop fibromyalgia. there is no cure for fibromyalgia, but medicine can help you manage your symptoms. getting enough sleep, exercising, and eating well may also help. nih: national institute of arthritis and musculoskeletal and skin diseases

MalaCards based summary: Fibromyalgia is related to chronic fatigue syndrome and serotonin syndrome. An important gene associated with Fibromyalgia is HTR3A (5-hydroxytryptamine (serotonin) receptor 3A, ionotropic), and among its related pathways are Ligand-gated ion channel transport and SIDS Susceptibility Pathways. The compounds ly 53857 and buspirone have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and brain, and related mouse phenotypes are homeostasis/metabolism and behavior/neurological.

CDC:4 NOTE: for the following sections using data based on ICD9-CM codes, there is no specific single code for fibromyalgia. According to coding rules, fibromyalgia is coded to 729.1 which is labeled “Myositis and Myalgia, unspecified” and can include other conditions. Thus, numbers based on ICDM9-CM code 729.1 for mortality, ambulatory care and hospitalizations may be overestimates.

Wikipedia:64 Fibromyalgia (FM or FMS) is characterised by chronic widespread pain and allodynia (a heightened and... more...

Aliases & Classifications for Fibromyalgia

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Sources:
11DISEASES, 44Novoseek, 33MedlinePlus, 61UMLS, 26ICD10
See all sources

Fibromyalgia, Aliases & Descriptions:

Name: Fibromyalgia 11 44 33 61


Classifications:



External Ids:

ICD1026 M79.7

Related Diseases for Fibromyalgia

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Diseases related to Fibromyalgia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 184)
idRelated DiseaseScoreTop Affiliating Genes
1chronic fatigue syndrome31.4CRH, SLC6A4
2serotonin syndrome30.6HTR2A, HTR3A
3irritable bowel syndrome30.6HTR3A, CRH, SLC6A4
4rheumatoid arthritis30.5SERPINA1, CRH, MEFV, TSPO
5hepatitis30.4SERPINA1, COMT
6migraine30.3SLC6A4, HTR2A, COMT, HTR3A
7obesity30.3HTR2A, NPY, CRH, COMT
8memory impairment30.2TSPO, HTR2A
9anxiety disorder30.0SLC6A4, CRH, HTR3A
10central nervous system disease30.0HTR2A, SLC6A4
11dementia29.9HTR2A, TSPO, COMT, HTR3A
12hypoglycemia29.7CRH, NPY, HTR2A, COMT
13eating disorder29.5HTR2A, COMT, CRH, NPY, SLC6A4, HTR3A
14mood disorder29.5SLC6A4, CRH, NPY, HTR3A, COMT, HTR2A
15myofascial pain syndrome10.6
16arthritis10.5
17blindness10.5
18melancholia10.5CRH
19neuropathy10.4
20alcoholic psychosis10.4SLC6A4
21premature ejaculation10.4SLC6A4
22amnestic disorder10.4TSPO, HTR3A
23heart valve disease10.3HTR2A, HTR3A
24schizophrenia10.3HTR2A, COMT
25alexithymia10.3
26chronic pain10.3
27dysautonomia10.3
28multiple chemical sensitivity10.3
29autonomic dysfunction10.3
30back pain10.3
31generalized anxiety disorder10.2TSPO, SLC6A4
32narcolepsy10.2HTR2A, COMT
33cocaine abuse10.2HTR3A, SLC6A4
34endogenous depression10.2SLC6A4, CRH
35eosinophilia-myalgia syndrome10.2
36eosinophilia10.2
37sleep disorder10.2
38rheumatic disease10.2
39antisocial personality disorder10.2HTR2A, SLC6A4
40pain agnosia10.2HTR3A, CRH
41galactosemia10.2SERPINA1, TSPO
42constipation10.2HTR3A, SLC6A4
43substance dependence10.2COMT, SLC6A4
44carcinoid syndrome10.2HTR3A, CRH, HTR2A
45conduct disorder10.2SLC6A4, COMT
46psoriatic arthritis10.2
47pain disorder10.2
48substance abuse10.2CRH, SLC6A4
49alcohol abuse10.2SLC6A4, COMT
50temporal lobe epilepsy10.1TSPO, NPY

Graphical network of the top 20 diseases related to Fibromyalgia:



Diseases related to fibromyalgia

Symptoms for Fibromyalgia

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Drugs & Therapeutics for Fibromyalgia

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Drug clinical trials:

Search ClinicalTrials for Fibromyalgia

Search NIH Clinical Center for Fibromyalgia

Genetic Tests for Fibromyalgia

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Anatomical Context for Fibromyalgia

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MalaCards organs/tissues related to Fibromyalgia:

32
Skin, Testes, Brain, Pituitary, Cortex, Heart, Bone, Thyroid, Monocytes, Breast, Endothelial, Neutrophil, Eye, Skeletal muscle, Lung, T cells, Cingulate cortex

Animal Models for Fibromyalgia or affiliated genes

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MGI Mouse Phenotypes related to Fibromyalgia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053767.8HTR3A, COMT, CRH, NPY, SLC6A4, MEFV
2MP:00053867.6SLC6A4, NPY, CRH, COMT, HTR3A, HTR2A

Publications for Fibromyalgia

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Articles related to Fibromyalgia:

(show top 50)    (show all 762)
idTitleAuthorsYear
1
Intra- and Inter-Patient Symptom Variability in Fibromyalgia: Results of a 90-Day Assessment. (25408116)
2014
2
Suicidal Ideation in Patients with Fibromyalgia: A Cross-Sectional Study. (24433278)
2014
3
Improving the primary care physicians' decision making for fibromyalgia in clinical practice: development and validation of the Fibromyalgia Detection (FibroDetectAr) screening tool. (25341959)
2014
4
The role of vitamin D in pathophysiology and treatment of fibromyalgia. (23801008)
2013
5
Brain correlates of cognitive inhibition in fibromyalgia: emotional intrusion of symptom-related words. (23557844)
2013
6
Meanings of feeling well for women with fibromyalgia. (23530542)
2013
7
Posttraumatic stress disorder in fibromyalgia syndrome: prevalence, temporal relationship between posttraumatic stress and fibromyalgia symptoms, and impact on clinical outcome. (23685006)
2013
8
Research to encourage exercise for fibromyalgia (REEF): use of motivational interviewing, outcomes from a randomized-controlled trial. (23042474)
2013
9
Validation of a Spanish version of the Revised Fibromyalgia Impact Questionnaire (FIQR). (23915386)
2013
10
Acylated ghrelin: a potential marker for fibromyalgia? (23475812)
2013
11
Trapezius activity of fibromyalgia patients is enhanced in stressful situations, but is similar to healthy controls in a quiet naturalistic setting: a case-control study. (23506457)
2013
12
Factors promoting sustainable work in women with fibromyalgia. (23336119)
2013
13
Prevalence of fibromyalgia in vasovagal syncope. (23519175)
2013
14
Trajectory of change in pain, depression, and physical functioning after physical activity adoption in fibromyalgia. (24165860)
2013
15
Serum level of brain-derived neurotrophic factor in fibromyalgia syndrome correlates with depression but not anxiety. (23318672)
2013
16
Cognitive impairment in fibromyalgia. (23709236)
2013
17
Fibromyalgia syndrome--novel therapeutic targets. (23742873)
2013
18
Feasibility of Interactive Technology for Symptom Monitoring in Patients with Fibromyalgia. (23434124)
2013
19
Extension trial of qigong for fibromyalgia: a quantitative and qualitative study. (24069054)
2013
20
Validation and psychometric properties of the Spanish version of the Quality of Life Scale (QOLS) in patients with fibromyalgia. (24097208)
2013
21
Classification and Clinical Diagnosis of Fibromyalgia Syndrome: Recommendations of Recent Evidence-Based Interdisciplinary Guidelines. (24379886)
2013
22
Effect of moderate to vigorous physical activity on long-term clinical outcomes and pain severity in fibromyalgia. (23401486)
2013
23
Association between fibromyalgia syndrome and polymorphism of the IL-4 gene in a Turkish population. (23644020)
2013
24
Longitudinal observation of treatment patterns and outcomes for patients with fibromyalgia: 12-month findings from the reflections study. (23758985)
2013
25
Quality of life and emotional functioning in youth with chronic migraine and juvenile fibromyalgia. (23446072)
2013
26
Fibromyalgia research indicates it is a spectrum disorder and not a disease. (24151889)
2013
27
Association of fibromyalgia with altered skeletal muscle characteristics which may contribute to postexertional fatigue in postmenopausal women. (23124535)
2013
28
Self-reported sensory descriptors are associated with quantitative sensory testing parameters in patients with cervical radiculopathy, but not in patients with fibromyalgia. (23108871)
2013
29
Increased brain responses during subjectively-matched mechanical pain stimulation in fibromyalgia patients as evidenced by MEG. (23121899)
2013
30
Effects of shiatsu in the management of fibromyalgia symptoms: a controlled pilot study. (23830713)
2013
31
Complementary therapies for fibromyalgia syndrome -- a rational approach. (23801007)
2013
32
Work-related physical trauma and fibromyalgia. (23996999)
2013
33
Bone mass and vitamin D levels in women with a diagnosis of fibromyalgia. (24008400)
2013
34
Fear-learning deficits in fibromyalgia: precursor or consequence? (24006368)
2013
35
A patient and physician survey of fibromyalgia across Latin America and Europe. (23767857)
2013
36
Hyperexcitable C nociceptors in fibromyalgia. (24243538)
2013
37
Survey Criteria for Fibromyalgia Independently Predict Increased Postoperative Opioid Consumption after Lower-extremity Joint Arthroplasty: A Prospective, Observational Cohort Study. (24343289)
2013
38
A 3-year, open-label, flexible-dosing study of milnacipran for the treatment of fibromyalgia. (23446068)
2013
39
Effects of a one week multidisciplinary inpatient self-management programme for patients with fibromyalgia: a randomised controlled trial. (23013162)
2012
40
Entheseal power Doppler ultrasonography: a comparison of psoriatic arthritis and fibromyalgia. (22751587)
2012
41
Sodium oxybate: not authorised for fibromyalgia. (23373093)
2012
42
Influence of the interaction between environmental quality and T102C SNP in the HTR2A gene on fibromyalgia susceptibility. (22124593)
2011
43
Pilot study to assess the frequency of fibromyalgia, depression, and sleep disorders in patients with granulomatosis with polyangiitis (Wegener's). (21337530)
2011
44
Missense mutations in the MEFV gene are associated with fibromyalgia syndrome and correlate with elevated IL-1beta plasma levels. (20041150)
2009
45
Alteration of serotonin transporter density and activity in fibromyalgia. (16790074)
2006
46
Neuroendocrine and hormonal perturbations and relations to the serotonergic system in fibromyalgia patients. (11028824)
2000
47
Plasma levels on nociceptin in female fibromyalgia syndrome patients. (10025089)
1998
48
Secretory pattern of GH, TSH, thyroid hormones, ACTH, cortisol, FSH, and LH in patients with fibromyalgia syndrome following systemic injection of the relevant hypothalamic-releasing hormones. (10025090)
1998
49
Possible concomitant fibromyalgia in systemic lupus erythematosus patients with overt central nervous system disease but with cognitive deficits: comment on the article by Kozora et al. (9259439)
1997
50
Hypothalamic-pituitary-adrenal axis perturbations in patients with fibromyalgia. (7980669)
1994

Variations for Fibromyalgia

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Expression for genes affiliated with Fibromyalgia

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Expression patterns in normal tissues for genes affiliated with Fibromyalgia

Search GEO for disease gene expression data for Fibromyalgia.

Pathways for genes affiliated with Fibromyalgia

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Compounds for genes affiliated with Fibromyalgia

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Compounds related to Fibromyalgia according to GeneCards/GeneDecks:

(show top 50)    (show all 175)
idCompoundScoreTop Affiliating Genes
1ly 53857449.8HTR2A, HTR3A
2buspirone44 29 1211.8HTR3A, TSPO, HTR2A
3mdl 100907449.8HTR2A, HTR3A
4benzodiazepine449.8HTR3A, CRH, TSPO
5mdl 72222449.7HTR2A, HTR3A
6allopregnanolone449.6TSPO, CRH, NPY
75,7-dihydroxytryptamine449.6SLC6A4, HTR2A
88-hydroxy-2-(di-n-propylamino)tetralin449.6SLC6A4, HTR3A, HTR2A
9m-chlorophenylpiperazine449.5SLC6A4, HTR3A, HTR2A
10mcpp449.5SLC6A4, HTR3A, HTR2A
11pindolol44 29 1211.5HTR3A, HTR2A, SLC6A4
12propranolol44 29 50 25 1213.5CRH, TSPO, COMT, HTR3A
13tegaserod44 29 1211.5HTR2A, HTR3A, SLC6A4
14sertraline44 29 50 25 1213.5HTR3A, CRH, SLC6A4
15alpha methyl 5 hydroxytryptamine449.5HTR2A, HTR3A
16nefazodone44 50 1211.5HTR3A, HTR2A, SLC6A4
175-hydroxyindoleacetic acid44 2510.4HTR3A, SLC6A4, CRH
18mianserin44 29 1211.4HTR2A, HTR3A, SLC6A4
19homovanillic acid44 2510.4COMT, SLC6A4, CRH
20ketanserin44 2910.4SLC6A4, HTR2A, HTR3A
21maoa449.4SLC6A4, HTR2A, COMT
22ondansetron50 44 25 1212.3HTR3A, HTR2A, SLC6A4
23spec-t449.3SLC6A4, CRH, TSPO
24yohimbine44 3 29 1212.3HTR2A, HTR3A, NPY, CRH
255-hydroxytryptophan449.2HTR3A, HTR2A, CRH, SLC6A4
26mirtazapine44 50 1211.2HTR2A, HTR3A, CRH, SLC6A4
27fluoxetine44 50 29 1212.2CRH, HTR3A, HTR2A, SLC6A4
28venlafaxine44 50 25 1212.2HTR2A, HTR3A, COMT, SLC6A4
29citalopram44 50 25 1212.2SLC6A4, HTR2A, HTR3A, CRH
30paroxetine44 50 29 1212.2SLC6A4, COMT, HTR3A, HTR2A
31risperidone44 50 29 60 25 1214.2HTR2A, SLC6A4, HTR3A, COMT
32olanzapine44 50 29 25 1213.1HTR3A, HTR2A, SLC6A4, COMT
33amitriptyline44 29 50 1212.1HTR3A, HTR2A, SLC6A4
34bupropion50 44 25 1212.1COMT, NPY, SLC6A4
35clozapine44 29 50 1212.1HTR2A, HTR3A, COMT, SLC6A4
36mhpg449.0NPY, CRH, COMT, SLC6A4
37opiate449.0SLC6A4, NPY, TSPO, CRH
38corticosterone44 60 2511.0NPY, SLC6A4, TSPO, CRH
39clomipramine44 50 1210.9SLC6A4, TSPO, HTR2A, HTR3A, CRH
40fluvoxamine44 50 1210.9SLC6A4, COMT, HTR3A, HTR2A, TSPO
41gaba448.8NPY, HTR3A, TSPO, SLC6A4, CRH
42Serotonin258.8SLC6A4, HTR3A, HTR2A, HTR3B
43haloperidol44 50 29 3 1212.7SLC6A4, NPY, HTR3A, HTR2A, TSPO
44fenfluramine44 29 1210.7CRH, NPY, SLC6A4, HTR3A, HTR2A
45cocaine44 129.7CRH, SLC6A4, NPY, COMT, TSPO
46nicotine44 29 50 1211.7TSPO, SLC6A4, NPY, CRH, COMT
47estrogen448.1COMT, CRH, SLC6A4, NPY, TSPO, SERPINA1
48norepinephrine44 25 1210.0SLC6A4, TSPO, HTR2A, HTR3A, COMT, CRH
49dopamine44 29 25 1211.0TSPO, HTR2A, HTR3A, COMT, CRH, NPY
505-hydroxytryptamine447.2SLC6A4, TSPO, HTR3B, HTR2A, HTR3A, COMT

GO Terms for genes affiliated with Fibromyalgia

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Cellular components related to Fibromyalgia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral component of plasma membraneGO:0058878.3SLC6A4, HTR3A, HTR2A, HTR3B

Biological processes related to Fibromyalgia according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1serotonin receptor signaling pathwayGO:0072109.9HTR2A, HTR3A
2adrenal gland developmentGO:0303259.9CRH, TSPO
3response to painGO:0482659.9CRH, COMT
4digestionGO:0075869.7NPY, HTR3A
5feeding behaviorGO:0076319.6CRH, NPY
6cation transportGO:0068129.3HTR3A, HTR3B
7memoryGO:0076139.1SLC6A4, HTR2A
8response to drugGO:0424938.6SLC6A4, CRH, COMT, HTR2A, TSPO
9synaptic transmissionGO:0072687.6NPY, TSPO, HTR3B, HTR2A, HTR3A, COMT

Molecular functions related to Fibromyalgia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuropeptide hormone activityGO:0051849.6NPY, CRH
2serotonin bindingGO:0513789.5HTR3A, HTR2A
3serotonin-activated cation-selective channel activityGO:0052329.3HTR3A, HTR3B
4serotonin receptor activityGO:0049938.9HTR3A, HTR2A, HTR3B

Products for genes affiliated with Fibromyalgia

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Sources for Fibromyalgia

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
29IUPHAR
30KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet