MCID: FBR017
MIFTS: 56

Fibrosarcoma malady

Bone, Cancer categories

Summaries for Fibrosarcoma

Sources:
64Wikipedia, 47OMIM, 33MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Wikipedia:64 Fibrosarcoma (fibroblastic sarcoma) is a malignant mesenchymal tumour derived from fibrous connective... more...

MalaCards: Fibrosarcoma, also known as fibrosarcoma of the soft tissue, is related to congenital fibrosarcoma and adenocarcinoma. An important gene associated with Fibrosarcoma is ETV6 (ets variant 6), and among its related pathways are Tacrolimus/Cyclosporine Pathway, Pharmacodynamics and Matrix Metalloproteinases. The drug dacarbazine and the compounds vegf and matrigel have been mentioned in the context of this disorder. Related mouse phenotypes are growth/size and mortality/aging.

Description from OMIM:47 117600

Aliases & Classifications for Fibrosarcoma

Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 49Orphanet, 47OMIM, 61UMLS, 57SNOMED-CT, 40NCIt, 35MeSH, 36MESH via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Bone


Characteristics (Orphanet epidemiological data):

49
fibrosarcoma:
Age of onset: Variable


Aliases & Descriptions:

fibrosarcoma 8 43 10 45 49 47 61
fibrosarcoma of the soft tissue 8
fibrosarcoma of soft tissue 8
neoplasms, fibrous tissue 61
fibrous tissue neoplasm 8
fibrocytic tumor 8


External Ids:

Disease Ontology8 DOID:3355
NCIt40 C3043
MeSH35 D005354
OMIM47 117600
SNOMED-CT57 443250000, 53654007
MESH via Orphanet36 D005354
SNOMED-CT via Orphanet58 53654007
UMLS via Orphanet62 C0016057

Related Diseases for Fibrosarcoma

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Fibrosarcoma family:

adult fibrosarcoma congenital fibrosarcoma

Diseases related to Fibrosarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 125)
idRelated DiseaseScoreTop Affiliating Genes
1congenital fibrosarcoma31.3ETV6, GOLGA6A, GOLGA6B
2adenocarcinoma30.0TFPI2, EGR1, NTRK3, ING1, MMP14, MMP2
3squamous cell carcinoma29.8PDGFRA, TFPI2, EGR1, ING1, MMP14, MMP2
4astrocytoma29.8PDGFRA, EGR1, MMP14, MMP2, MMP9
5stomach cancer29.8MMP9, MMP2, MMP14, ING1, EGR1
6breast fibrosarcoma10.4
7heart fibrosarcoma10.4
8adult fibrosarcoma10.4
9liver fibrosarcoma10.3
10inflammatory myofibroblastic tumor10.3
11fibrous histiocytoma10.3
12dermatofibrosarcoma10.3
13kidney fibrosarcoma10.3
14dermatofibrosarcoma protuberans10.3
15mesoblastic nephroma10.3
16small bowel fibrosarcoma10.2
17hypoxia10.2
18conventional fibrosarcoma10.2
19central nervous system fibrosarcoma10.2
20bone osteosarcoma10.2
21myofibroma10.1
22fibrosarcoma of bone10.1
23hypoglycemia10.1
24n syndrome10.1
25basal cell carcinoma10.1
26desmoid tumor10.1
27cellular congenital mesoblastic nephroma10.0
28nevoid basal cell carcinoma syndrome10.0
29spindle cell sarcoma10.0
30acute leukemia10.0
31spindle cell lipoma10.0
32diaphyseal medullary stenosis with malignant fibrous histiocytoma10.0
33nevo syndrome10.0
34fibromatosis10.0
35infantile myofibromatosis10.0
36malignant mesenchymal tumor10.0
37teratoma10.0
38breast cancer10.0TFPI2, STC1, EGR1, NTRK3, ETV6, MMP14
39hepatocellular carcinoma10.0PDGFRA, TFPI2, STC1, EGR1, ING1, MMP14
40melanoma10.0PDGFRA, TFPI2, EGR1, NTRK3, ING1, MMP14
41brain cancer10.0PDGFRA, TFPI2, EGR1, NTRK3, ING1, MMP14
42non-small cell lung carcinoma10.0PDGFRA, TFPI2, EGR1, MMP14, MMP2, MMP9
43glioblastoma multiforme10.0PDGFRA, TFPI2, EGR1, MMP14, MMP2, MMP9
44lung cancer10.0PDGFRA, TFPI2, EGR1, ING1, MMP2, MMP9
45osteosarcoma10.0PDGFRA, EGR1, ING1, MMP14, MMP2, MMP9
46colon cancer10.0EGR1, NTRK3, MMP14, MMP2, MMP9
47leukemia10.0PDGFRA, STC1, EGR1, NTRK3, ETV6
48malignant glioma10.0PDGFRA, EGR1, MMP14, MMP2, MMP9
49squamous cell carcinoma of the head and neck10.0MMP9, MMP2, MMP14, EGR1
50lung adenocarcinoma10.0MMP9, MMP2, MMP14, NTRK3

Graphical network of the top 20 diseases related to Fibrosarcoma:



Diseases related to fibrosarcoma

Clinical Features for Fibrosarcoma

Sources:
47OMIM
See all sources

Clinical features from OMIM:

117600

Clinical synopsis from OMIM:

117600

Drugs & Therapeutics for Fibrosarcoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Fibrosarcoma

Drug clinical trials:

Search ClinicalTrials for Fibrosarcoma

Search NIH Clinical Center for Fibrosarcoma

Search CenterWatch for Fibrosarcoma

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Fibrosarcoma

Anatomical Context for Fibrosarcoma

Animal Models for Fibrosarcoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Fibrosarcoma

Sources:
51PubMed
See all sources

Articles related to Fibrosarcoma:

(show top 50)    (show all 798)
idTitleAuthorsYear
1
Inhibition of Growth and Induction of Apoptosis in Fibrosarcoma Cell Lines by Echinophora platyloba DC: In Vitro Analysis. (23365566)
2013
2
A young woman with a giant breast fibrosarcoma: a case report. (24255792)
2013
3
Primary fibrosarcoma of kidney. (23314136)
2013
4
EWSR1 rearrangements in sclerosing epithelioid fibrosarcoma. (24025527)
2013
5
Tetraspanin CD9 promotes the invasive phenotype of human fibrosarcoma cells via upregulation of matrix metalloproteinase-9. (23840773)
2013
6
Long acting propranolol and HSP-70 rich tumor lysate reduce tumor growth and enhance immune response against fibrosarcoma in Balb/c mice. (23811546)
2013
7
Giant primary ovarian fibrosarcoma: Case report and review of pitfalls. (23326031)
2012
8
Salidroside inhibits migration and invasion of human fibrosarcoma HT1080 cells. (21978886)
2012
9
The acromion thoracic flap: a reconstructive resource after exeresis of a parotid fibrosarcoma. (21196871)
2011
10
A rare case of locally advanced fibrosarcoma of diaphysal humerus managed successfully with limb-sparing procedures after neoadjuvant chemotherapy. (20819211)
2010
11
A giant congenital fibrosarcoma of the leg. (20442675)
2010
12
A newborn with infantile fibrosarcoma of foot: treatment with chemotherapy and extremity-sparing surgery. (20038940)
2010
13
Infantile fibrosarcoma of the ileum presenting with congenital bowel obstruction. (20152376)
2010
14
Stabilization of anaphase midzone microtubules is regulated by Rho during cytokinesis in human fibrosarcoma cells. (19576212)
2009
15
Specific roles of Rac1 and Rac2 in motile functions of HT1080 fibrosarcoma cells. (19555660)
2009
16
Endobronchial metastasis from oral fibrosarcoma 13 years after treatment of primary tumor. (19787473)
2009
17
Congenital fibrosarcoma with a novel complex 3-way translocation t(12;15;19) and unusual histologic features. (18657299)
2008
18
A citrus polymethoxyflavonoid, nobiletin, is a novel MEK inhibitor that exhibits antitumor metastasis in human fibrosarcoma HT-1080 cells. (18053806)
2008
19
Collagen-binding domains of gelatinase A and thrombospondin-derived peptides impede endocytic clearance of active gelatinase A and promote HT1080 fibrosarcoma cell invasion. (18222489)
2008
20
Down-regulation of phosphoglucose isomerase/autocrine motility factor results in mesenchymal-to-epithelial transition of human lung fibrosarcoma cells. (17483335)
2007
21
Functional analysis of matrix metalloproteinases and tissue inhibitors of metalloproteinases differentially expressed by variants of human HT-1080 fibrosarcoma exhibiting high and low levels of intravasation and metastasis. (17895241)
2007
22
Down regulation of 3p genes, LTF, SLC38A3 and DRR1, upon growth of human chromosome 3-mouse fibrosarcoma hybrids in severe combined immunodeficiency mice. (16432833)
2006
23
Synchronous fibrosarcoma and medullary thyroid cancer in a man with AIDS. (17023794)
2006
24
Malignant transformation of ameloblastic fibroma to ameloblastic fibrosarcoma: case report and review of the literature. (16129612)
2005
25
The augmentation of TNFalpha-induced cell death in murine L929 fibrosarcoma by the pan-caspase inhibitor Z-VAD-fmk through pre-mitochondrial and MAPK-dependent pathways. (16418768)
2005
26
Peripheral-type benzodiazepine receptor (PBR) and PBR drug ligands in fibroblast and fibrosarcoma cell proliferation: role of ERK, c-Jun and ligand-activated PBR-independent pathways. (15130769)
2004
27
Combined sellar fibrosarcoma and prolactinoma with neuronal metaplasia: report of a case unassociated with radiotherapy. (15299201)
2004
28
Management of extensive congenital fibrosarcoma with preoperative chemotherapy. (15456453)
2004
29
Assessment of the antiinvasive potential of the anthracycline aclacinomycin (Aclarubicin) in a human fibrosarcoma cell line. (15138606)
2004
30
Spectrum of low-grade fibrosarcomas: a comparative ultrastructural analysis of low-grade myxofibrosarcoma and fibromyxoid sarcoma. (15764580)
2004
31
Congenital fibrosarcoma of the jejunum in a premature infant with meconium peritonitis. (12776248)
2003
32
Cumulative influence of elastin peptides and plasminogen on matrix metalloproteinase activation and type I collagen invasion by HT-1080 fibrosarcoma cells. (11964074)
2002
33
Type IV collagen induces matrix metalloproteinase 2 activation in HT1080 fibrosarcoma cells. (11112341)
2000
34
ETV6-NTRK3 gene fusion in metastasizing congenital fibrosarcoma. (10918240)
2000
35
Recurrent dermatofibrosarcoma protuberans with total fibrosarcomatous change. (10029495)
1999
36
Dermatofibrosarcoma protuberans with fibrosarcomatous areas. Molecular abnormalities of the p53 pathway in fibrosarcomatous transformation of dermatofibrosarcoma protuberans. (9808434)
1998
37
ETV6-NTRK3 gene fusions and trisomy 11 establish a histogenetic link between mesoblastic nephroma and congenital fibrosarcoma. (9823307)
1998
38
Malignant stromal tumor consistent with fibrosarcoma arising from Meckel's diverticulum. Clinicopathological study of an incidentally discovered tumor and review of the literature. (9267492)
1997
39
Plasminogen activator inhibitor-1 accelerates lung metastasis formation of human fibrosarcoma cells. (9066670)
1997
40
Anti-invasive activity of ursolic acid correlates with the reduced expression of matrix metalloproteinase-9 (MMP-9) in HT1080 human fibrosarcoma cells. (8625299)
1996
41
Use of the stress-inducible grp78/BiP promoter in targeting high level gene expression in fibrosarcoma in vivo. (7712471)
1995
42
Congenital fibrosarcoma. Report of three cases. (8772821)
1995
43
Macrophage priming and activation during fibrosarcoma growth: expression of c-myb, c-myc, c-fos, and c-fms. (7851963)
1994
44
Potentiation of K252a, a protein kinase inhibitor-induced polyploidization by cAMP in cultured fibrosarcoma cell line. (7999107)
1994
45
Comparative effects of a recombinant and a mutein type of granulocyte colony stimulating factor on the growth of Meth-A fibrosarcoma with 5-fluorouracil chemotherapy. (1377928)
1992
46
Central fibrosarcoma of bone. Report of a case. (452904)
1979
47
Fibrosarcoma of bone. A study of 114 cases. (5249422)
1969
48
Nevoid basal cell carcinoma syndrome with associated fibrosarcoma of the maxilla. Report of a case. (5641334)
1968
49
Right ventricular fibrosarcoma causing pulmonic stenosis. (5929663)
1966
50
Fibrosarcoma of bone. (13458607)
1957

Genetic Variations for Fibrosarcoma

Expression for genes affiliated with Fibrosarcoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Fibrosarcoma

Search GEO for disease gene expression data for Fibrosarcoma.

Pathways for genes affiliated with Fibrosarcoma

Sources:
50PharmGKB, 38NCBI BioSystems Database, 52QIAGEN, 4Cell Signaling Technology, 12EMD Millipore, 54Reactome
See all sources

Pathways related to Fibrosarcoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
111.0MAFB, MAFA, MAFG, MAFK, MAF, MAFF
2
Hide members
10.8MMP9, MMP2, MMP14, TFPI2
310.8PDGFRA, MMP2, MMP9
4
Cell adhesion ECM remodeling
Hide members
10.8MMP9, MMP2, MMP14
510.8MMP9, MMP2, MMP14
6
Hide members
10.7MMP14, MMP2

Compounds for genes affiliated with Fibrosarcoma

Sources:
45Novoseek, 60Tocris Bioscience, 24HMDB, 11DrugBank, 2BitterDB
See all sources

Compounds related to Fibrosarcoma according to GeneCards/GeneDecks:

(show all 44)
idCompoundScoreTop Affiliating Genes
1vegf4511.6PDGFRA, STC1, EGR1, NTRK3, ETV6, MMP14
2matrigel4511.5TFPI2, EGR1, NTRK3, MMP14, MMP2, MMP9
3leucine4511.4EGR1, MAFG, MAFK, MAF, MAFF, MMP14
4phosphatidylinositol4511.4PDGFRA, EGR1, NTRK3, MMP14, MMP2, MMP9
5tgf beta14511.4PDGFRA, EGR1, MMP14, MMP2, MMP9
6ag 14784511.3MMP9, MMP2, MMP14, EGR1
7aspartate4511.3PDGFRA, TFPI2, NTRK3, MMP2, MMP9
8sp 60012545 6012.2MMP9, MMP2, MMP14, EGR1
9cytochalasin d45 6012.2EGR1, MMP14, MMP2, MMP9
10flavanol4511.2MMP9, MMP2, MMP14
11curcumin4511.2EGR1, MMP14, MMP2, MMP9
12prinomastat4511.2MMP14, MMP2, MMP9
13retinoic acid45 2412.2PDGFRA, EGR1, NTRK3, ETV6, MMP2, MMP9
14ilomastat4511.2MMP9, MMP2, MMP14
15uk 3833676011.2MMP14, MMP2, MMP9
16gi 254023x6011.2MMP14, MMP2, MMP9
17gm 60016011.2MMP14, MMP2, MMP9
18phorbol-12-myristate4511.2EGR1, MMP14, MMP9
19hydroxamate4511.2MMP14, MMP2, MMP9
20marimastat45 60 1113.1MMP9, MMP2, MMP14
21tbhq4511.1MAF, MAFK, MAFG
22ribonucleic acid4511.1EGR1, MMP14, MMP2, MMP9
231,10-phenanthroline45 212.1MMP9, MMP2, MMP14
24batimastat45 60 1113.1MMP9, MMP2, MMP14
2512-o-tetradecanoylphorbol 13-acetate4511.1EGR1, MMP14, MMP2, MMP9
26cgs-27023a4511.0MMP2, MMP9
27methyl selenol4511.0MMP2, MMP9
28col 34511.0MMP2, MMP9
29pdtc4511.0MMP9, MMP2, MAFG
30trapidil4511.0MMP9, MMP2
31lercanidipine45 1112.0MMP9, MMP2
32tranilast4511.0MMP9, MMP2
33estrogen4511.0ING1
34tetracycline45 1111.9MMP14, MMP2, MMP9
35gelfoam4510.9MMP9, MMP2
36pd 98,0594510.9EGR1, MMP14, MMP2, MMP9
37cilomilast4510.9MMP9, MMP2
38latanoprost45 1111.9MMP9, MMP2
39cycloheximide4510.9NTRK3
40ly2940024510.8MMP9, MMP2, MMP14, EGR1
41grgdsp4510.8MMP2, MMP14
42p0024510.8MMP9, MMP14, TFPI2
43wortmannin4510.7EGR1, MMP14, MMP2, MMP9
44phorbol4510.5MMP9, MMP2, EGR1

GO Terms for genes affiliated with Fibrosarcoma

Sources:
16Gene Ontology
See all sources

Biological processes related to Fibrosarcoma according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1embryo implantationGO:00756610.9MMP9, MMP2, STC1
2collagen catabolic processGO:03057410.8MMP14, MMP2, MMP9
3regulation of epidermal cell differentiationGO:04560410.8MAFF, MAFG
4positive regulation of cell migrationGO:03033510.8MMP14, NTRK3, PDGFRA
5extracellular matrix disassemblyGO:02261710.8MMP9, MMP2, MMP14
6extracellular matrix organizationGO:03019810.7PDGFRA, MMP14, MMP2, MMP9
7transcription from RNA polymerase II promoterGO:00636610.5MAFF, MAF, NFE2L3, EGR1

Molecular functions related to Fibrosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1sequence-specific DNA bindingGO:04356511.2ETV6, EGR1, NFE2L3, MAFA, MAFG, MAFK
2sequence-specific DNA binding transcription factor activityGO:00370011.1EGR1, NFE2L3, MAFA, MAFG, MAFK, MAF
3metalloendopeptidase activityGO:00422210.8MMP9, MMP2, MMP14

Products for genes affiliated with Fibrosarcoma

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Fibrosarcoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet