MCID: FBR017
MIFTS: 63

Fibrosarcoma malady

Rare diseases, Bone diseases, Cancer diseases categories
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Summaries for Fibrosarcoma

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Disease Ontology:8 A connective tissue cancer that has material basis in fibrous connective tissue and characterized by the presence of immature proliferating fibroblasts or undifferentiated anaplastic spindle cells in a storiform pattern.

MalaCards based summary: Fibrosarcoma, also known as fibrosarcoma of soft tissue, is related to congenital fibrosarcoma and congenital mesoblastic nephroma, and has symptoms including An important gene associated with Fibrosarcoma is ETV6 (ets variant 6), and among its related pathways are Factors involved in megakaryocyte development and platelet production and Matrix Metalloproteinases. The drug dacarbazine and the compounds flavanol and prinomastat have been mentioned in the context of this disorder. Affiliated tissues include bone, breast and colon, and related mouse phenotypes are craniofacial and renal/urinary system.

Wikipedia:65 Fibrosarcoma (fibroblastic sarcoma) is a malignant mesenchymal tumour derived from fibrous connective... more...

Description from OMIM:46 117600

Aliases & Classifications for Fibrosarcoma

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 48Orphanet, 46OMIM, 62UMLS, 57SNOMED-CT, 34MeSH, 39NCIt, 35MESH via Orphanet, 63UMLS via Orphanet
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Fibrosarcoma, Aliases & Descriptions:

Name: Fibrosarcoma 8 42 10 44 48 46 62
Fibrosarcoma of Soft Tissue 8 62
Neoplasms, Fibrous Tissue 62
 
Fibrous Tissue Neoplasm 8
Fibrocytic Tumor 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Bone diseases


Characteristics (Orphanet epidemiological data):

48
fibrosarcoma:
Age of onset: Variable


External Ids:

Disease Ontology8 DOID:3355
MeSH34 D005354
NCIt39 C3043
SNOMED-CT57 53654007, 443250000
OMIM46 117600
MESH via Orphanet35 D005354
UMLS via Orphanet63 C0016057

Related Diseases for Fibrosarcoma

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Diseases in the Fibrosarcoma family:

Congenital Fibrosarcoma Adult Fibrosarcoma

Diseases related to Fibrosarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 147)
idRelated DiseaseScoreTop Affiliating Genes
1congenital fibrosarcoma31.7GOLGA6A, GOLGA6B, ETV6
2congenital mesoblastic nephroma30.7NTRK3, ETV6
3leukemia30.0HMMR, PDGFRA, NTRK3, STC1, ETV6, APRT
4adenocarcinoma29.8NTRK3, MMP14, MMP2, TFPI2, SPINK1
5glioblastoma29.8PDGFRA, MMP14, MMP2, TFPI2
6prostate cancer29.6SPINK1, MMP2, MMP14, NTRK3, PDGFRA
7breast cancer29.5MMP2, MMP14, ETV6, STC1, NTRK3, HMMR
8fibrosarcoma of bone10.6
9parotitis10.5SPINK1
10pdgfrb-associated chronic eosinophilic leukemia10.4PDGFRA, ETV6
11sarcoma10.4
12mastocytosis10.4PDGFRA, NTRK3
13bone marrow cancer10.3ETV6, NTRK3, PDGFRA
14keratitis10.3MMP2
15serous cystadenocarcinoma10.3MMP14, MMP2
16breast fibrosarcoma10.3
17dermatofibrosarcoma protuberans10.3
18osteosarcoma10.3
19peripheral t-cell lymphoma10.3ETV6, PDGFRA
20heart fibrosarcoma10.3
21fibroma10.3
22fibrous histiocytoma10.3
23adult fibrosarcoma10.3
24histiocytoma10.3
25mesoblastic nephroma10.3
26abdominal aortic aneurysm10.2MMP14, MMP2
27small bowel fibrosarcoma10.2
28central nervous system fibrosarcoma10.2
29kidney fibrosarcoma10.2
30hypoxia10.2
31endometriosis10.2MMP2, MMP14, PDGFRA
32hemangioma10.2
33inflammatory myofibroblastic tumor10.2
34liver fibrosarcoma10.2
35chondrosarcoma10.2
36liposarcoma10.2
37rhabdomyosarcoma10.2
38thyroiditis10.2
39brain cancer10.2PDGFRA, NTRK3, MMP14, TFPI2
40chronic myeloid leukemia10.1PDGFRA, NTRK3, ETV6
41malignant glioma10.1MMP2, MMP14, PDGFRA
42hypoglycemia10.1
43cerebritis10.1
44conventional fibrosarcoma10.1
45basal cell carcinoma10.1
46fasciitis10.1
47pediatric fibrosarcoma10.1
48desmoid tumor10.1
49diaphyseal medullary stenosis with malignant fibrous histiocytoma10.1
50endotheliitis10.1

Graphical network of the top 20 diseases related to Fibrosarcoma:



Diseases related to fibrosarcoma

Symptoms for Fibrosarcoma

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Symptoms by clinical synopsis from OMIM:

117600

Clinical features from OMIM:

117600

HPO human phenotypes related to Fibrosarcoma:

id Description Frequency HPO Source Accession
1 autosomal dominant inheritance HP:0000006
2 fibrosarcoma HP:0100244

Drugs & Therapeutics for Fibrosarcoma

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Drug clinical trials:

Search ClinicalTrials for Fibrosarcoma

Search NIH Clinical Center for Fibrosarcoma

Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Fibrosarcoma

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Anatomical Context for Fibrosarcoma

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MalaCards organs/tissues related to Fibrosarcoma:

32
Bone, Breast, Colon, Lung, Heart, T cells, Liver, Ovary, Thyroid, Brain, Kidney, Skin, Endothelial, Pancreas, Myeloid, Monocytes, Tongue, Pituitary, Lymph node, Thymus, Prostate, Nk cells

Animal Models for Fibrosarcoma or affiliated genes

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Publications for Fibrosarcoma

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Articles related to Fibrosarcoma:

(show top 50)    (show all 782)
idTitleAuthorsYear
1
Congenital infantile fibrosarcoma of the lip. (24138391)
2014
2
Physalin A induces apoptotic cell death and protective autophagy in HT1080 human fibrosarcoma cells. (23647462)
2013
3
Congenital fibrosarcoma of the bowel: Sonographic description of a rare case of neonatal intestinal obstruction. (24281989)
2013
4
Intraosseous fibrosarcoma of maxilla in an HIV patient. (22208447)
2012
5
Mediators of receptor tyrosine kinase activation in infantile fibrosarcoma: a Children's Oncology Group study. (22374738)
2012
6
Fibrosarcoma arising from a burn scar. (21865123)
2011
7
Chaotic neovascularization induced by aggressive fibrosarcoma cells overexpressing S-adenosylmethionine decarboxylase. (21134486)
2011
8
Anticancer effects of fullerene [C60] included in polyethylene glycol combined with visible light irradiation through ROS generation and DNA fragmentation on fibrosarcoma cells with scarce cytotoxicity to normal fibroblasts. (21542456)
2011
9
Molecular cytogenetics reveals complex karyotype in apparent t(8;13) therapy-related acute myeloid leukemia M2 after fibrosarcoma. (21329977)
2011
10
Giant primary pulmonary fibrosarcoma. (20578405)
2010
11
A rare case of locally advanced fibrosarcoma of diaphysal humerus managed successfully with limb-sparing procedures after neoadjuvant chemotherapy. (20819211)
2010
12
Zoledronic acid inhibits proliferation of human fibrosarcoma cells with induction of apoptosis, and shows combined effects with other anticancer agents. (20514467)
2010
13
Abdominal fibrosarcoma associated with a retained surgical swab in a dog. (20096417)
2010
14
Cellular mesoblastic nephroma (infantile renal fibrosarcoma): institutional review of the clinical, diagnostic imaging, and pathologic features of a distinctive neoplasm of infancy. (19629465)
2009
15
Congenital fibrosarcoma with a novel complex 3-way translocation t(12;15;19) and unusual histologic features. (18657299)
2008
16
Frzb, a secreted Wnt antagonist, decreases growth and invasiveness of fibrosarcoma cells associated with inhibition of Met signaling. (18451162)
2008
17
Opposing effects of fibrosarcoma cell-derived IL-1 alpha and IL-1 beta on immune response induction. (18412246)
2008
18
Vaginal fibrosarcoma in a cow. (21851697)
2007
19
A unique fibrous tumor of the ovary: fibrosarcoma or mitotically active cellular fibroma? (18214045)
2007
20
Sclerosing epithelioid fibrosarcoma of the pituitary. (18097772)
2007
21
Dynamic contrast enhanced MRI of mouse fibrosarcoma using small-molecular and novel macromolecular contrast agents. (18061121)
2007
22
Junctional adhesion molecule-C promotes metastatic potential of HT1080 human fibrosarcoma. (17227766)
2007
23
Non-apoptotic programmed cell death induced by a copper(II) complex in human fibrosarcoma cells. (16733666)
2006
24
Stable expression of a heterogeneous gene introduced via gene targeting into the HPRT locus of human fibrosarcoma cells. (16807926)
2006
25
Inhibitory effects of caffeic acid phenethyl ester on cancer cell metastasis mediated by the down-regulation of matrix metalloproteinase expression in human HT1080 fibrosarcoma cells. (16214327)
2006
26
Congenital infantile fibrosarcoma: a masquerader of ulcerated hemangioma. (16918626)
2006
27
Unexpected effect of matrix metalloproteinase down-regulation on vascular intravasation and metastasis of human fibrosarcoma cells selected in vivo for high rates of dissemination. (16322244)
2005
28
Coxofemoral arthroscopy and total hip arthroplasty for management of intermediate grade fibrosarcoma in a dog. (15720595)
2005
29
Inhibitory effects of adrenomedullary hormone on the induction and growth of fibrosarcoma by methylcholanthrene. (15855881)
2005
30
99mTc-MDP uptake in fibrosarcoma in a cat. (15977148)
2005
31
Peripheral-type benzodiazepine receptor (PBR) and PBR drug ligands in fibroblast and fibrosarcoma cell proliferation: role of ERK, c-Jun and ligand-activated PBR-independent pathways. (15130769)
2004
32
Congenital fibrosarcoma with metastasis in a fetus. (15022058)
2004
33
Plakoglobin is a new target gene of histone deacetylase in human fibrosarcoma HT1080 cells. (14661058)
2004
34
Giant fibrosarcoma arising in dermatofibrosarcoma protuberans on the scalp during pregnancy. (12614428)
2003
35
Apoptosis induced by butyrate is independent of Jak/STAT signaling in a fibrosarcoma cell line. (12589807)
2003
36
Effects of tea polyphenols on the invasion and matrix metalloproteinases activities of human fibrosarcoma HT1080 cells. (10794635)
1999
37
Highly activated matrix metalloproteinase-2 secreted from clones of metastatic lung nodules of nude mice injected with human fibrosarcoma HT1080. (10656606)
1999
38
Overexpression of manganese superoxide dismutase selectively modulates the activity of Jun-associated transcription factors in fibrosarcoma cells. (9393747)
1997
39
Suppression of transformed phenotypes of human fibrosarcoma cells by overexpression of recombinant fibronectin. (8813154)
1996
40
Intrathoracic congenital fibrosarcoma. A case report. (7608883)
1995
41
Congenital fibrosarcoma masquerading as lymphatic malformation: report of two cases. (7722837)
1995
42
Single-base deletion induced by benzo[a]pyrene diol epoxide at the adenine phosphoribosyltransferase locus in human fibrosarcoma cell lines. (7510848)
1994
43
Primary rhabdomyosarcoma of the iliac bone in an adult: a case mimicking fibrosarcoma. (8212536)
1993
44
Interaction of topoisomerase I inhibitors with radiation in cis-diamminedichloroplatinum(II)-sensitive and -resistant cells in vitro and in the FSAIIC fibrosarcoma in vivo. (8416195)
1993
45
Congenital fibrosarcoma of the forearm. A case report. (3957990)
1986
46
Mechanism of activation of an N-ras gene in the human fibrosarcoma cell line HT1080. (6086315)
1984
47
Metastatic spread of fibrosarcoma of bone; A report on forty-nine cases, and a comparison with osteosarcoma. (1071090)
1976
48
Pancreaticoduodenectomy in the treatment of congenital fibrosarcoma of the duodenum. (1185470)
1975
49
Ultrastructure of congenital fibrosarcoma. (5483658)
1970
50
Congenital fibrosarcoma. (13095275)
1953

Variations for Fibrosarcoma

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Expression for genes affiliated with Fibrosarcoma

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Expression patterns in normal tissues for genes affiliated with Fibrosarcoma

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Pathways for genes affiliated with Fibrosarcoma

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Pathways related to Fibrosarcoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8MAFG, MAFF, MAFK
2
Show member pathways
9.6TFPI2, MMP2, MMP14
39.1MAFB, MAFG, MAFA, MAFF, MAF, MAFK

Compounds for genes affiliated with Fibrosarcoma

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Compounds related to Fibrosarcoma according to GeneCards/GeneDecks:

(show all 17)
idCompoundScoreTop Affiliating Genes
1flavanol4410.3MMP14, MMP2
2prinomastat4410.3MMP14, MMP2
3ilomastat4410.3MMP14, MMP2
4grgdsp4410.3MMP14, MMP2
5uk 3833676110.2MMP2, MMP14
6gi 254023x6110.1MMP2, MMP14
7imatinib44 50 1112.1PDGFRA, NTRK3, ETV6
8gm 60016110.1MMP2, MMP14
9tbhq4410.1MAFG, MAF, MAFK
10tgf beta14410.0MMP2, MMP14, PDGFRA
11hydroxamate449.9MMP14, MMP2
12marimastat44 61 1111.7MMP14, MMP2
13matrigel449.7TFPI2, MMP2, MMP14, NTRK3
14leucine449.7MMP14, MAFK, MAF, MAFF, MAFG
15aspartate449.5TFPI2, MMP2, NTRK3, PDGFRA
16vegf449.4MMP2, MMP14, ETV6, STC1, NTRK3, PDGFRA
17tyrosine449.1MMP14, ETV6, NTRK3, PDGFRA, HMMR, MMP2

GO Terms for genes affiliated with Fibrosarcoma

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Biological processes related to Fibrosarcoma according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1regulation of epidermal cell differentiationGO:04560410.2MAFG, MAFF
2positive regulation of cell migrationGO:03033510.0PDGFRA, NTRK3, MMP14
3face morphogenesisGO:0603259.9PDGFRA, MMP2
4embryo implantationGO:0075669.9STC1, MMP2
5transcription from RNA polymerase II promoterGO:0063669.7ETV6, MAF, MAFF, NFE2L3
6angiogenesisGO:0015259.5MMP14, MMP2, AIMP1
7blood coagulationGO:0075969.3TFPI2, MAFK, MAFF, MAFG

Molecular functions related to Fibrosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transmembrane receptor protein tyrosine kinase activityGO:00471410.1PDGFRA, NTRK3
2sequence-specific DNA bindingGO:0435658.6NFE2L3, ETV6, MAFK, MAF, MAFF, MAFA
3sequence-specific DNA binding transcription factor activityGO:0037008.2MMP14, ETV6, MAFK, MAF, MAFF, MAFA

Products for genes affiliated with Fibrosarcoma

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Sources for Fibrosarcoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet