MCID: FBR017
MIFTS: 52

Fibrosarcoma malady

Rare diseases, Bone diseases, Cancer diseases categories

Aliases & Classifications for Fibrosarcoma

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Sources:
9Disease Ontology, 41NIH Rare Diseases, 11DISEASES, 43Novoseek, 47Orphanet, 60UMLS, 38NCIt, 33MeSH, 55SNOMED-CT, 34MESH via Orphanet, 61UMLS via Orphanet
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Fibrosarcoma, Aliases & Descriptions:

Name: Fibrosarcoma 9 41 11 43 47 60
Fibrosarcoma of Soft Tissue 9
Neoplasms, Fibrous Tissue 60
 
Soft Tissue Fibrosarcoma 60
Fibrous Tissue Neoplasm 9
Fibrocytic Tumor 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Bone diseases


Characteristics (Orphanet epidemiological data):

47
fibrosarcoma:
Prevalence: <1/1000000 (Europe); Age of onset: All ages


External Ids:

Disease Ontology9 DOID:3355
NCIt38 C3043
MeSH33 D005354
SNOMED-CT55 443250000, 53654007
Orphanet47 2030
MESH via Orphanet34 D005354
UMLS via Orphanet61 C0016057

Summaries for Fibrosarcoma

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Disease Ontology:9 A connective tissue cancer that has material basis in fibrous connective tissue and characterized by the presence of immature proliferating fibroblasts or undifferentiated anaplastic spindle cells in a storiform pattern.

MalaCards based summary: Fibrosarcoma, also known as fibrosarcoma of soft tissue, is related to congenital fibrosarcoma and congenital mesoblastic nephroma. An important gene associated with Fibrosarcoma is ETV6 (ets variant 6), and among its related pathways are Factors involved in megakaryocyte development and platelet production and Matrix Metalloproteinases. The drug dacarbazine and the compounds flavanol and prinomastat have been mentioned in the context of this disorder. Affiliated tissues include bone, colon and breast, and related mouse phenotypes are craniofacial and renal/urinary system.

Wikipedia:63 Fibrosarcoma (fibroblastic sarcoma) is a malignant mesenchymal tumour derived from fibrous connective... more...

Related Diseases for Fibrosarcoma

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Diseases in the Fibrosarcoma family:

Congenital Fibrosarcoma Adult Fibrosarcoma

Diseases related to Fibrosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 148)
idRelated DiseaseScoreTop Affiliating Genes
1congenital fibrosarcoma31.7GOLGA6A, GOLGA6B, ETV6
2congenital mesoblastic nephroma30.7NTRK3, ETV6
3abdominal aortic aneurysm30.2MMP14, MMP2
4leukemia30.0HMMR, PDGFRA, NTRK3, STC1, ETV6, APRT
5glioblastoma29.8PDGFRA, MMP14, MMP2, TFPI2
6adenocarcinoma29.8NTRK3, MMP14, MMP2, TFPI2, SPINK1
7prostate cancer29.6SPINK1, MMP2, MMP14, NTRK3, PDGFRA
8hepatocellular carcinoma29.5SPINK1, TFPI2, MMP2, MMP14, STC1, PDGFRA
9breast cancer29.5MMP2, MMP14, ETV6, STC1, NTRK3, HMMR
10fibrosarcoma of bone10.6
11parotitis10.5SPINK1
12chronic myelomonocytic leukemia10.4PDGFRA, ETV6
13sarcoma10.4
14mastocytosis10.4PDGFRA, NTRK3
15bone marrow cancer10.3ETV6, NTRK3, PDGFRA
16adult fibrosarcoma10.3
17keratitis10.3MMP2
18serous cystadenocarcinoma10.3MMP14, MMP2
19dermatofibrosarcoma protuberans10.3
20breast fibrosarcoma10.3
21peripheral t-cell lymphoma10.3ETV6, PDGFRA
22heart fibrosarcoma10.3
23fibroma10.3
24small bowel fibrosarcoma10.3
25fibrous histiocytoma10.3
26histiocytoma10.3
27mesoblastic nephroma10.3
28inflammatory myofibroblastic tumor10.2
29liver fibrosarcoma10.2
30central nervous system fibrosarcoma10.2
31kidney fibrosarcoma10.2
32hypoxia10.2
33endometriosis10.2MMP2, MMP14, PDGFRA
34chondrosarcoma10.2
35diaphyseal medullary stenosis with malignant fibrous histiocytoma10.2
36hemangioma10.2
37conventional fibrosarcoma10.2
38liposarcoma10.2
39pediatric fibrosarcoma10.2
40rhabdomyosarcoma10.2
41thyroiditis10.2
42brain cancer10.2PDGFRA, NTRK3, MMP14, TFPI2
43leukemia, chronic myeloid10.1PDGFRA, NTRK3, ETV6
44malignant glioma10.1MMP2, MMP14, PDGFRA
45hypoglycemia10.1
46cerebritis10.1
47basal cell carcinoma10.1
48fasciitis10.1
49peritonitis10.1
50endotheliitis10.1

Graphical network of the top 20 diseases related to Fibrosarcoma:



Diseases related to fibrosarcoma

Symptoms for Fibrosarcoma

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Drugs & Therapeutics for Fibrosarcoma

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Drug clinical trials:

Search ClinicalTrials for Fibrosarcoma

Search NIH Clinical Center for Fibrosarcoma

Inferred drug relations via UMLS60/NDF-RT39:

Genetic Tests for Fibrosarcoma

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Anatomical Context for Fibrosarcoma

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MalaCards organs/tissues related to Fibrosarcoma:

31
Bone, Colon, Breast, Lung, Heart, T cells, Ovary, Liver, Thyroid, Brain, Kidney, Skin, Endothelial, Pancreas, Myeloid, Monocytes, Tongue, Pituitary, Lymph node, Thymus, Prostate, Nk cells

Animal Models for Fibrosarcoma or affiliated genes

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Publications for Fibrosarcoma

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Articles related to Fibrosarcoma:

(show top 50)    (show all 803)
idTitleAuthorsYear
1
Acute peritonitis caused by a fibrosarcoma of the transverse colon in an adult. (25580415)
2014
2
Congenital infantile fibrosarcoma of the lip. (24138391)
2014
3
Physalin A induces apoptotic cell death and protective autophagy in HT1080 human fibrosarcoma cells. (23647462)
2013
4
Congenital fibrosarcoma of the bowel: Sonographic description of a rare case of neonatal intestinal obstruction. (24281989)
2013
5
Intraosseous fibrosarcoma of maxilla in an HIV patient. (22208447)
2012
6
Mediators of receptor tyrosine kinase activation in infantile fibrosarcoma: a Children's Oncology Group study. (22374738)
2012
7
Fibrosarcoma arising from a burn scar. (21865123)
2011
8
Chaotic neovascularization induced by aggressive fibrosarcoma cells overexpressing S-adenosylmethionine decarboxylase. (21134486)
2011
9
Anticancer effects of fullerene [C60] included in polyethylene glycol combined with visible light irradiation through ROS generation and DNA fragmentation on fibrosarcoma cells with scarce cytotoxicity to normal fibroblasts. (21542456)
2011
10
Molecular cytogenetics reveals complex karyotype in apparent t(8;13) therapy-related acute myeloid leukemia M2 after fibrosarcoma. (21329977)
2011
11
Giant primary pulmonary fibrosarcoma. (20578405)
2010
12
A rare case of locally advanced fibrosarcoma of diaphysal humerus managed successfully with limb-sparing procedures after neoadjuvant chemotherapy. (20819211)
2010
13
Zoledronic acid inhibits proliferation of human fibrosarcoma cells with induction of apoptosis, and shows combined effects with other anticancer agents. (20514467)
2010
14
Abdominal fibrosarcoma associated with a retained surgical swab in a dog. (20096417)
2010
15
Cellular mesoblastic nephroma (infantile renal fibrosarcoma): institutional review of the clinical, diagnostic imaging, and pathologic features of a distinctive neoplasm of infancy. (19629465)
2009
16
Congenital fibrosarcoma with a novel complex 3-way translocation t(12;15;19) and unusual histologic features. (18657299)
2008
17
Frzb, a secreted Wnt antagonist, decreases growth and invasiveness of fibrosarcoma cells associated with inhibition of Met signaling. (18451162)
2008
18
Opposing effects of fibrosarcoma cell-derived IL-1 alpha and IL-1 beta on immune response induction. (18412246)
2008
19
Vaginal fibrosarcoma in a cow. (21851697)
2007
20
A unique fibrous tumor of the ovary: fibrosarcoma or mitotically active cellular fibroma? (18214045)
2007
21
Sclerosing epithelioid fibrosarcoma of the pituitary. (18097772)
2007
22
Dynamic contrast enhanced MRI of mouse fibrosarcoma using small-molecular and novel macromolecular contrast agents. (18061121)
2007
23
Junctional adhesion molecule-C promotes metastatic potential of HT1080 human fibrosarcoma. (17227766)
2007
24
Non-apoptotic programmed cell death induced by a copper(II) complex in human fibrosarcoma cells. (16733666)
2006
25
Stable expression of a heterogeneous gene introduced via gene targeting into the HPRT locus of human fibrosarcoma cells. (16807926)
2006
26
Inhibitory effects of caffeic acid phenethyl ester on cancer cell metastasis mediated by the down-regulation of matrix metalloproteinase expression in human HT1080 fibrosarcoma cells. (16214327)
2006
27
Congenital infantile fibrosarcoma: a masquerader of ulcerated hemangioma. (16918626)
2006
28
Unexpected effect of matrix metalloproteinase down-regulation on vascular intravasation and metastasis of human fibrosarcoma cells selected in vivo for high rates of dissemination. (16322244)
2005
29
Coxofemoral arthroscopy and total hip arthroplasty for management of intermediate grade fibrosarcoma in a dog. (15720595)
2005
30
Inhibitory effects of adrenomedullary hormone on the induction and growth of fibrosarcoma by methylcholanthrene. (15855881)
2005
31
Peripheral-type benzodiazepine receptor (PBR) and PBR drug ligands in fibroblast and fibrosarcoma cell proliferation: role of ERK, c-Jun and ligand-activated PBR-independent pathways. (15130769)
2004
32
Congenital fibrosarcoma with metastasis in a fetus. (15022058)
2004
33
Plakoglobin is a new target gene of histone deacetylase in human fibrosarcoma HT1080 cells. (14661058)
2004
34
Giant fibrosarcoma arising in dermatofibrosarcoma protuberans on the scalp during pregnancy. (12614428)
2003
35
Apoptosis induced by butyrate is independent of Jak/STAT signaling in a fibrosarcoma cell line. (12589807)
2003
36
Effects of tea polyphenols on the invasion and matrix metalloproteinases activities of human fibrosarcoma HT1080 cells. (10794635)
1999
37
Highly activated matrix metalloproteinase-2 secreted from clones of metastatic lung nodules of nude mice injected with human fibrosarcoma HT1080. (10656606)
1999
38
Overexpression of manganese superoxide dismutase selectively modulates the activity of Jun-associated transcription factors in fibrosarcoma cells. (9393747)
1997
39
Suppression of transformed phenotypes of human fibrosarcoma cells by overexpression of recombinant fibronectin. (8813154)
1996
40
Intrathoracic congenital fibrosarcoma. A case report. (7608883)
1995
41
Congenital fibrosarcoma masquerading as lymphatic malformation: report of two cases. (7722837)
1995
42
Single-base deletion induced by benzo[a]pyrene diol epoxide at the adenine phosphoribosyltransferase locus in human fibrosarcoma cell lines. (7510848)
1994
43
Primary rhabdomyosarcoma of the iliac bone in an adult: a case mimicking fibrosarcoma. (8212536)
1993
44
Interaction of topoisomerase I inhibitors with radiation in cis-diamminedichloroplatinum(II)-sensitive and -resistant cells in vitro and in the FSAIIC fibrosarcoma in vivo. (8416195)
1993
45
Congenital fibrosarcoma of the forearm. A case report. (3957990)
1986
46
Mechanism of activation of an N-ras gene in the human fibrosarcoma cell line HT1080. (6086315)
1984
47
Metastatic spread of fibrosarcoma of bone; A report on forty-nine cases, and a comparison with osteosarcoma. (1071090)
1976
48
Pancreaticoduodenectomy in the treatment of congenital fibrosarcoma of the duodenum. (1185470)
1975
49
Ultrastructure of congenital fibrosarcoma. (5483658)
1970
50
Congenital fibrosarcoma. (13095275)
1953

Variations for Fibrosarcoma

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Expression for genes affiliated with Fibrosarcoma

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Search GEO for disease gene expression data for Fibrosarcoma.

Pathways for genes affiliated with Fibrosarcoma

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Pathways related to Fibrosarcoma according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8MAFG, MAFF, MAFK
2
Show member pathways
9.6TFPI2, MMP2, MMP14
39.1MAFB, MAFG, MAFA, MAFF, MAF, MAFK

Compounds for genes affiliated with Fibrosarcoma

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Compounds related to Fibrosarcoma according to GeneCards Suite gene sharing:

(show all 17)
idCompoundScoreTop Affiliating Genes
1flavanol4310.3MMP14, MMP2
2prinomastat4310.3MMP14, MMP2
3ilomastat4310.3MMP14, MMP2
4grgdsp4310.3MMP14, MMP2
5uk 3833675910.2MMP2, MMP14
6gi 254023x5910.1MMP2, MMP14
7imatinib43 49 1212.1PDGFRA, NTRK3, ETV6
8gm 60015910.1MMP2, MMP14
9tbhq4310.1MAFG, MAF, MAFK
10tgf beta14310.0MMP2, MMP14, PDGFRA
11hydroxamate439.9MMP14, MMP2
12marimastat43 59 1211.7MMP14, MMP2
13matrigel439.7TFPI2, MMP2, MMP14, NTRK3
14leucine439.7MMP14, MAFK, MAF, MAFF, MAFG
15aspartate439.5TFPI2, MMP2, NTRK3, PDGFRA
16vegf439.4MMP2, MMP14, ETV6, STC1, NTRK3, PDGFRA
17tyrosine439.1MMP14, ETV6, NTRK3, PDGFRA, HMMR, MMP2

GO Terms for genes affiliated with Fibrosarcoma

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Biological processes related to Fibrosarcoma according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1regulation of epidermal cell differentiationGO:004560410.2MAFG, MAFF
2positive regulation of cell migrationGO:003033510.0PDGFRA, NTRK3, MMP14
3face morphogenesisGO:00603259.9PDGFRA, MMP2
4embryo implantationGO:00075669.9STC1, MMP2
5transcription from RNA polymerase II promoterGO:00063669.7ETV6, MAF, MAFF, NFE2L3
6angiogenesisGO:00015259.5MMP14, MMP2, AIMP1
7blood coagulationGO:00075969.3TFPI2, MAFK, MAFF, MAFG

Molecular functions related to Fibrosarcoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1transmembrane receptor protein tyrosine kinase activityGO:000471410.1PDGFRA, NTRK3
2sequence-specific DNA bindingGO:00435658.6NFE2L3, ETV6, MAFK, MAF, MAFF, MAFA
3sequence-specific DNA binding transcription factor activityGO:00037008.2MMP14, ETV6, MAFK, MAF, MAFF, MAFA

Products for genes affiliated with Fibrosarcoma

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Sources for Fibrosarcoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet