MCID: FBR017
MIFTS: 66

Fibrosarcoma malady

Bone diseases, Cancer diseases categories

Summaries for Fibrosarcoma

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63Wikipedia, 46OMIM, 32MalaCards
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Wikipedia:63 Fibrosarcoma (fibroblastic sarcoma) is a malignant mesenchymal tumour derived from fibrous connective... more...

MalaCards: Fibrosarcoma, also known as fibrosarcoma of the soft tissue, is related to congenital fibrosarcoma and osteosarcoma. An important gene associated with Fibrosarcoma is ETV6 (ets variant 6), and among its related pathways are Tacrolimus/Cyclosporine Pathway, Pharmacodynamics and Matrix Metalloproteinases. The drug dacarbazine and the compounds vegf and matrigel have been mentioned in the context of this disorder. Affiliated tissues include bone, breast and colon, and related mouse phenotypes are growth/size and mortality/aging.

Description from OMIM:46 117600

Aliases & Classifications for Fibrosarcoma

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 48Orphanet, 46OMIM, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH, 35MESH via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Bone diseases


Characteristics (Orphanet epidemiological data):

48
fibrosarcoma:
Age of onset: Variable


Aliases & Descriptions:

fibrosarcoma 8 42 10 44 48 46 60
fibrosarcoma of the soft tissue 8
fibrosarcoma of soft tissue 8
neoplasms, fibrous tissue 60
fibrous tissue neoplasm 8
fibrocytic tumor 8


External Ids:

Disease Ontology8 DOID:3355
NCIt39 C3043
MeSH34 D005354
OMIM46 117600
SNOMED-CT56 443250000, 53654007
MESH via Orphanet35 D005354
SNOMED-CT via Orphanet57 53654007
UMLS via Orphanet61 C0016057

Related Diseases for Fibrosarcoma

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17GeneCards, 18GeneDecks
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Diseases in the Fibrosarcoma family:

Adult Fibrosarcoma Congenital Fibrosarcoma

Diseases related to Fibrosarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 142)
idRelated DiseaseScoreTop Affiliating Genes
1congenital fibrosarcoma31.2ETV6, GOLGA6A, GOLGA6B
2osteosarcoma30.4PDGFRA, EGR1, ING1, MMP14, MMP2, MMP9
3congenital mesoblastic nephroma30.2ETV6, NTRK3
4chondrosarcoma30.2MMP14, PDGFRA
5leukemia30.1PDGFRA, STC1, EGR1, NTRK3, ETV6
6breast cancer30.0TFPI2, STC1, EGR1, NTRK3, ETV6, MMP14
7adenocarcinoma30.0TFPI2, EGR1, NTRK3, ING1, MMP14, MMP2
8hepatocellular carcinoma29.7PDGFRA, TFPI2, STC1, EGR1, ING1, MMP14
9squamous cell carcinoma29.7PDGFRA, TFPI2, EGR1, ING1, MMP14, MMP2
10astrocytoma29.7PDGFRA, EGR1, MMP14, MMP2, MMP9
11colon cancer29.7EGR1, NTRK3, MMP14, MMP2, MMP9
12myeloid leukemia29.7EGR1, NTRK3, ETV6
13stomach cancer29.7MMP9, MMP2, MMP14, ING1, EGR1
14fibrosarcoma of bone10.6
15breast fibrosarcoma10.4
16heart fibrosarcoma10.4
17adult fibrosarcoma10.3
18liver fibrosarcoma10.3
19sarcoma10.3
20fibrous histiocytoma10.2
21dermatofibrosarcoma10.2
22kidney fibrosarcoma10.2
23histiocytoma10.2
24pediatric fibrosarcoma10.2
25small bowel fibrosarcoma10.2
26conventional fibrosarcoma10.1
27central nervous system fibrosarcoma10.1
28bone osteosarcoma10.1
29hemangioma10.1
30liposarcoma10.1
31rhabdomyosarcoma10.1
32thyroiditis10.1
33malignant fibrous histiocytoma of bone10.1
34cerebritis10.1
35hypoglycemia10.1
36basal cell carcinoma10.1
37fasciitis10.1
38melanoma10.0PDGFRA, TFPI2, EGR1, NTRK3, ING1, MMP14
39brain cancer10.0PDGFRA, TFPI2, EGR1, NTRK3, ING1, MMP14
40non-small cell lung carcinoma10.0PDGFRA, TFPI2, EGR1, MMP14, MMP2, MMP9
41glioblastoma multiforme10.0PDGFRA, TFPI2, EGR1, MMP14, MMP2, MMP9
42lung cancer10.0PDGFRA, TFPI2, EGR1, ING1, MMP2, MMP9
43malignant glioma10.0PDGFRA, EGR1, MMP14, MMP2, MMP9
44squamous cell carcinoma of the head and neck10.0MMP9, MMP2, MMP14, EGR1
45lung adenocarcinoma10.0MMP9, MMP2, MMP14, NTRK3
46aneurysm disease10.0MMP9, MMP2, MMP14
47bladder carcinoma10.0MMP9, MMP2, MMP14, EGR1
48myelodysplastic syndromes10.0PDGFRA, EGR1, ETV6
49myeloproliferative disorder10.0ETV6, NTRK3, PDGFRA
50prostate cancer10.0MMP9, MMP2, MMP14, EGR1

Graphical network of the top 20 diseases related to Fibrosarcoma:



Diseases related to fibrosarcoma

Clinical Features for Fibrosarcoma

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Sources:
46OMIM
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Clinical features from OMIM:

117600

Clinical synopsis from OMIM:

117600

Drugs & Therapeutics for Fibrosarcoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Fibrosarcoma

Drug clinical trials:

Search ClinicalTrials for Fibrosarcoma

Search NIH Clinical Center for Fibrosarcoma

Search CenterWatch for Fibrosarcoma

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Fibrosarcoma

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Anatomical Context for Fibrosarcoma

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32MalaCards
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MalaCards organs/tissues related to Fibrosarcoma:

32
Bone, Breast, Colon, Lung, Heart, T cells, Ovary, Liver, Thyroid, Kidney, Endothelial, Pancreas, Tongue, Monocytes, Myeloid, Skin, Brain, Pituitary, Thymus, Nk cells, Lymph node

Animal Models for Fibrosarcoma or affiliated genes

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36MGI
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Publications for Fibrosarcoma

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50PubMed
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Articles related to Fibrosarcoma:

(show top 50)    (show all 767)
idTitleAuthorsYear
1
Infantile fibrosarcoma-a clinical and histologic mimicker of vascular malformations: case report and review of the literature. (23718697)
2013
2
Prenatal presentation of fronto-orbital congenital infantile fibrosarcoma: a clinicopathologic report. (23559269)
2013
3
EWSR1 rearrangements in sclerosing epithelioid fibrosarcoma. (24025527)
2013
4
Intraosseous fibrosarcoma of maxilla in an HIV patient. (22208447)
2012
5
Picture of the month: diagnosis: infantile fibrosarcoma. (22945322)
2012
6
Ameloblastic fibrosarcoma of the mandible: report of 2 chemosensitive pediatric cases. (22009005)
2012
7
Picture of the month-quiz case. Infantile Fibrosarcoma. (22945321)
2012
8
miR-520c and miR-373 upregulate MMP9 expression by targeting mTOR and SIRT1, and activate the Ras/Raf/MEK/Erk signaling pathway and NF-I_B factor in human fibrosarcoma cells. (21898400)
2012
9
Recurrent congenital fibrosarcoma with heart metastases. (22217490)
2012
10
Cranial fasciitis resembling infantile fibrosarcoma differentiated by genetic assay. (21366679)
2011
11
Primary congenital infantile fibrosarcoma of the heart: the first confirmed case. (21440163)
2011
12
The histone deacetylase inhibitor vorinostat selectively sensitizes fibrosarcoma cells to chemotherapy. (20957741)
2011
13
Small interfering RNA targeting HIF-1I+ reduces hypoxia-dependent transcription and radiosensitizes hypoxic HT 1080 human fibrosarcoma cells in vitro. (21437769)
2011
14
Congenital fibrosarcoma of the chest wall: report of a case. (21430833)
2010
15
Infantile fibrosarcoma: management based on the European experience. (19917847)
2010
16
Dendritic cell-based immunotherapy induces transient clinical response in advanced rat fibrosarcoma - comparison with preventive anti-tumour vaccination. (19691918)
2009
17
Does incorporation of gene for green fluorescent protein in BP6 fibrosarcoma tumor cells depress their intraperitoneal growth in rats? (In honour of Nobel Prize laureates 2008--Osamu Shimomura, Martin Chalfie, Roger Y. Tsien). (19507630)
2009
18
Molecular mechanisms of oridonin-induced apoptosis and autophagy in murine fibrosarcoma L929 cells. (19202353)
2009
19
Identification of integrins alpha6 and beta7 as c-Jun- and transformation-relevant genes in highly invasive fibrosarcoma cells. (19405119)
2009
20
Preclinical studies of [61Cu]ATSM as a PET radiopharmaceutical for fibrosarcoma imaging. (19304557)
2009
21
Unusual synchronous presentation of maxillary sinus fibrosarcoma and gemistocytic astrocytoma with a complication called leukocytoclastic vasculitis: a case report. (19756200)
2009
22
Vaginal fibrosarcoma in a cow. (21851697)
2007
23
Junctional adhesion molecule-C promotes metastatic potential of HT1080 human fibrosarcoma. (17227766)
2007
24
Translocation-positive low-grade fibromyxoid sarcoma: clinicopathologic and molecular analysis of a series expanding the morphologic spectrum and suggesting potential relationship to sclerosing epithelioid fibrosarcoma: a study from the French Sarcoma Group. (17721195)
2007
25
Cytologic appearance of a keloidal fibrosarcoma in a dog. (18041704)
2007
26
Primary cerebral fibrosarcoma in a child. (18232594)
2007
27
Reduction of invasion in human fibrosarcoma cells by ribosomal protein S3 in conjunction with Nm23-H1 and ERK. (16814409)
2006
28
Ginsenoside 20(S)-protopanaxadiol inhibits the proliferation and invasion of human fibrosarcoma HT1080 cells. (16700822)
2006
29
Malignant fibrous histiocytoma: pleomorphic sarcoma NOS or pleomorphic fibrosarcoma]. (15702318)
2005
30
Focal adhesion kinase is activated in invading fibrosarcoma cells and regulates metastasis. (16320111)
2005
31
Congenital fibrosarcoma of the upper extremity--a case report and review of literature. (16366098)
2005
32
Early detection of tumor response to chemotherapy by 3'-deoxy-3'-[18F]fluorothymidine positron emission tomography: the effect of cisplatin on a fibrosarcoma tumor model in vivo. (15899811)
2005
33
Fibrosarcoma in yellow perch, Perca flavescens (Mitchill). (15892756)
2005
34
Genetic analysis of fibrosarcoma of bone, a rare tumour entity closely related to osteosarcoma and malignant fibrous histiocytoma of bone. (15540465)
2004
35
Assessment of the antiinvasive potential of the anthracycline aclacinomycin (Aclarubicin) in a human fibrosarcoma cell line. (15138606)
2004
36
Giant fibrosarcoma arising in dermatofibrosarcoma protuberans on the scalp during pregnancy. (12614428)
2003
37
Fibrosarcoma associated with a benign cystic teratoma of the ovary. (11748992)
2002
38
TNP-470 Suppresses the Tumorigenicity of HT1080 Fibrosarcoma Tumor Through the Inhibition of VEGF Secretion From the Tumor Cells. (18521314)
2001
39
Role of phosphoinositide 3-kinase in the aggressive tumor growth of HT1080 human fibrosarcoma cells. (11486024)
2001
40
Extracellular signal-regulated kinase functions in the urokinase receptor-dependent pathway by which neutralization of low density lipoprotein receptor-related protein promotes fibrosarcoma cell migration and matrigel invasion. (10591631)
2000
41
Highly activated matrix metalloproteinase-2 secreted from clones of metastatic lung nodules of nude mice injected with human fibrosarcoma HT1080. (10656606)
1999
42
Eradication of primary murine fibrosarcomas and induction of systemic immunity by adenovirus-mediated interferon beta gene therapy. (10537298)
1999
43
Suppression of human fibrosarcoma cell growth by transcription factor, Egr-1, involves down-regulation of Bcl-2. (9714058)
1998
44
The activation of ProMMP-2 (gelatinase A) by HT1080 fibrosarcoma cells is promoted by culture on a fibronectin substrate and is concomitant with an increase in processing of MT1-MMP (MMP-14) to a 45 kDa form. (9718371)
1998
45
Congenital fibrosarcoma masquerading as congenital hemangioma: report of two cases. (8523253)
1995
46
Single-base deletion induced by benzo[a]pyrene diol epoxide at the adenine phosphoribosyltransferase locus in human fibrosarcoma cell lines. (7510848)
1994
47
Enhancement of in vitro prostaglandin E2 production by mouse fibrosarcoma cells after co-culture with various anti-tumour effector cells. (8054271)
1994
48
Down-regulation of SPARC/osteonectin/BM-40 expression in methylcholanthrene-induced fibrosarcomas and in Kirsten-MSV transformed fibroblasts. (1826444)
1991
49
Near triploidy in a feline fibrosarcoma. (1771983)
1991
50
Congenital fibrosarcoma: presence of a histiocytic component. (7388769)
1980

Genetic Variations for Fibrosarcoma

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Expression for genes affiliated with Fibrosarcoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Fibrosarcoma

Search GEO for disease gene expression data for Fibrosarcoma.

Pathways for genes affiliated with Fibrosarcoma

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49PharmGKB, 37NCBI BioSystems Database, 51QIAGEN, 4Cell Signaling Technology, 12EMD Millipore, 53Reactome
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Pathways related to Fibrosarcoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
111.0MAFB, MAFA, MAFG, MAFK, MAF, MAFF
2
Hide members
10.8MMP9, MMP2, MMP14, TFPI2
310.8PDGFRA, MMP2, MMP9
4
Cell adhesion ECM remodeling
Hide members
10.8MMP9, MMP2, MMP14
510.8MMP9, MMP2, MMP14
6
Hide members
10.7MMP14, MMP2

Compounds for genes affiliated with Fibrosarcoma

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44Novoseek, 59Tocris Bioscience, 24HMDB, 11DrugBank, 2BitterDB
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Compounds related to Fibrosarcoma according to GeneCards/GeneDecks:

(show all 44)
idCompoundScoreTop Affiliating Genes
1vegf4411.6PDGFRA, STC1, EGR1, NTRK3, ETV6, MMP14
2matrigel4411.5TFPI2, EGR1, NTRK3, MMP14, MMP2, MMP9
3leucine4411.4EGR1, MAFG, MAFK, MAF, MAFF, MMP14
4phosphatidylinositol4411.4PDGFRA, EGR1, NTRK3, MMP14, MMP2, MMP9
5tgf beta14411.4PDGFRA, EGR1, MMP14, MMP2, MMP9
6ag 14784411.3MMP9, MMP2, MMP14, EGR1
7aspartate4411.3PDGFRA, TFPI2, NTRK3, MMP2, MMP9
8sp 60012544 5912.2MMP9, MMP2, MMP14, EGR1
9cytochalasin d44 5912.2EGR1, MMP14, MMP2, MMP9
10flavanol4411.2MMP9, MMP2, MMP14
11curcumin4411.2EGR1, MMP14, MMP2, MMP9
12prinomastat4411.2MMP14, MMP2, MMP9
13retinoic acid44 2412.2PDGFRA, EGR1, NTRK3, ETV6, MMP2, MMP9
14ilomastat4411.2MMP9, MMP2, MMP14
15uk 3833675911.2MMP14, MMP2, MMP9
16gi 254023x5911.2MMP14, MMP2, MMP9
17gm 60015911.2MMP14, MMP2, MMP9
18phorbol-12-myristate4411.2EGR1, MMP14, MMP9
19hydroxamate4411.2MMP14, MMP2, MMP9
20marimastat44 59 1113.1MMP9, MMP2, MMP14
21tbhq4411.1MAF, MAFK, MAFG
22ribonucleic acid4411.1EGR1, MMP14, MMP2, MMP9
231,10-phenanthroline44 212.1MMP9, MMP2, MMP14
24batimastat44 59 1113.1MMP9, MMP2, MMP14
2512-o-tetradecanoylphorbol 13-acetate4411.1EGR1, MMP14, MMP2, MMP9
26cgs-27023a4411.0MMP2, MMP9
27methyl selenol4411.0MMP2, MMP9
28col 34411.0MMP2, MMP9
29pdtc4411.0MMP9, MMP2, MAFG
30trapidil4411.0MMP9, MMP2
31lercanidipine44 1112.0MMP9, MMP2
32tranilast4411.0MMP9, MMP2
33estrogen4411.0ING1
34tetracycline44 1111.9MMP14, MMP2, MMP9
35gelfoam4410.9MMP9, MMP2
36pd 98,0594410.9EGR1, MMP14, MMP2, MMP9
37cilomilast4410.9MMP9, MMP2
38latanoprost44 1111.9MMP9, MMP2
39cycloheximide4410.9NTRK3
40ly2940024410.8MMP9, MMP2, MMP14, EGR1
41grgdsp4410.8MMP2, MMP14
42p0024410.8MMP9, MMP14, TFPI2
43wortmannin4410.7EGR1, MMP14, MMP2, MMP9
44phorbol4410.5MMP9, MMP2, EGR1

GO Terms for genes affiliated with Fibrosarcoma

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16Gene Ontology
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Biological processes related to Fibrosarcoma according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1embryo implantationGO:00756610.9MMP9, MMP2, STC1
2collagen catabolic processGO:03057410.8MMP14, MMP2, MMP9
3regulation of epidermal cell differentiationGO:04560410.8MAFF, MAFG
4positive regulation of cell migrationGO:03033510.8MMP14, NTRK3, PDGFRA
5extracellular matrix disassemblyGO:02261710.8MMP9, MMP2, MMP14
6extracellular matrix organizationGO:03019810.7PDGFRA, MMP14, MMP2, MMP9
7transcription from RNA polymerase II promoterGO:00636610.5MAFF, MAF, NFE2L3, EGR1

Molecular functions related to Fibrosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1sequence-specific DNA bindingGO:04356511.2ETV6, EGR1, NFE2L3, MAFA, MAFG, MAFK
2sequence-specific DNA binding transcription factor activityGO:00370011.1EGR1, NFE2L3, MAFA, MAFG, MAFK, MAF
3metalloendopeptidase activityGO:00422210.8MMP9, MMP2, MMP14

Products for genes affiliated with Fibrosarcoma

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Sources for Fibrosarcoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet