MCID: FBR017
MIFTS: 66

Fibrosarcoma malady

Bone diseases, Cancer diseases categories

Summaries for Fibrosarcoma

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63Wikipedia, 46OMIM, 32MalaCards
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Wikipedia:63 Fibrosarcoma (fibroblastic sarcoma) is a malignant mesenchymal tumour derived from fibrous connective... more...

MalaCards: Fibrosarcoma, also known as fibrosarcoma of the soft tissue, is related to congenital fibrosarcoma and osteosarcoma. An important gene associated with Fibrosarcoma is ETV6 (ets variant 6), and among its related pathways are Tacrolimus/Cyclosporine Pathway, Pharmacodynamics and Matrix Metalloproteinases. The drug dacarbazine and the compounds vegf and matrigel have been mentioned in the context of this disorder. Affiliated tissues include bone, breast and colon, and related mouse phenotypes are growth/size and mortality/aging.

Description from OMIM:46 117600

Aliases & Classifications for Fibrosarcoma

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 48Orphanet, 46OMIM, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH, 35MESH via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Bone diseases


Characteristics (Orphanet epidemiological data):

48
fibrosarcoma:
Age of onset: Variable


Aliases & Descriptions:

fibrosarcoma 8 42 10 44 48 46 60
fibrosarcoma of the soft tissue 8
fibrosarcoma of soft tissue 8
neoplasms, fibrous tissue 60
fibrous tissue neoplasm 8
fibrocytic tumor 8


External Ids:

Disease Ontology8 DOID:3355
NCIt39 C3043
MeSH34 D005354
OMIM46 117600
SNOMED-CT56 443250000, 53654007
MESH via Orphanet35 D005354
SNOMED-CT via Orphanet57 53654007
UMLS via Orphanet61 C0016057

Related Diseases for Fibrosarcoma

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17GeneCards, 18GeneDecks
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Diseases in the Fibrosarcoma family:

Adult Fibrosarcoma Congenital Fibrosarcoma

Diseases related to Fibrosarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 142)
idRelated DiseaseScoreTop Affiliating Genes
1congenital fibrosarcoma31.2ETV6, GOLGA6A, GOLGA6B
2osteosarcoma30.4PDGFRA, EGR1, ING1, MMP14, MMP2, MMP9
3congenital mesoblastic nephroma30.2ETV6, NTRK3
4chondrosarcoma30.2MMP14, PDGFRA
5leukemia30.1PDGFRA, STC1, EGR1, NTRK3, ETV6
6breast cancer30.0TFPI2, STC1, EGR1, NTRK3, ETV6, MMP14
7adenocarcinoma30.0TFPI2, EGR1, NTRK3, ING1, MMP14, MMP2
8hepatocellular carcinoma29.7PDGFRA, TFPI2, STC1, EGR1, ING1, MMP14
9squamous cell carcinoma29.7PDGFRA, TFPI2, EGR1, ING1, MMP14, MMP2
10astrocytoma29.7PDGFRA, EGR1, MMP14, MMP2, MMP9
11colon cancer29.7EGR1, NTRK3, MMP14, MMP2, MMP9
12myeloid leukemia29.7EGR1, NTRK3, ETV6
13stomach cancer29.7MMP9, MMP2, MMP14, ING1, EGR1
14fibrosarcoma of bone10.6
15breast fibrosarcoma10.4
16heart fibrosarcoma10.4
17adult fibrosarcoma10.3
18liver fibrosarcoma10.3
19sarcoma10.3
20fibrous histiocytoma10.2
21dermatofibrosarcoma10.2
22kidney fibrosarcoma10.2
23histiocytoma10.2
24pediatric fibrosarcoma10.2
25small bowel fibrosarcoma10.2
26conventional fibrosarcoma10.1
27central nervous system fibrosarcoma10.1
28bone osteosarcoma10.1
29hemangioma10.1
30liposarcoma10.1
31rhabdomyosarcoma10.1
32thyroiditis10.1
33malignant fibrous histiocytoma of bone10.1
34cerebritis10.1
35hypoglycemia10.1
36basal cell carcinoma10.1
37fasciitis10.1
38melanoma10.0PDGFRA, TFPI2, EGR1, NTRK3, ING1, MMP14
39brain cancer10.0PDGFRA, TFPI2, EGR1, NTRK3, ING1, MMP14
40non-small cell lung carcinoma10.0PDGFRA, TFPI2, EGR1, MMP14, MMP2, MMP9
41glioblastoma multiforme10.0PDGFRA, TFPI2, EGR1, MMP14, MMP2, MMP9
42lung cancer10.0PDGFRA, TFPI2, EGR1, ING1, MMP2, MMP9
43malignant glioma10.0PDGFRA, EGR1, MMP14, MMP2, MMP9
44squamous cell carcinoma of the head and neck10.0MMP9, MMP2, MMP14, EGR1
45lung adenocarcinoma10.0MMP9, MMP2, MMP14, NTRK3
46aneurysm disease10.0MMP9, MMP2, MMP14
47bladder carcinoma10.0MMP9, MMP2, MMP14, EGR1
48myelodysplastic syndromes10.0PDGFRA, EGR1, ETV6
49myeloproliferative disorder10.0ETV6, NTRK3, PDGFRA
50prostate cancer10.0MMP9, MMP2, MMP14, EGR1

Graphical network of the top 20 diseases related to Fibrosarcoma:



Diseases related to fibrosarcoma

Clinical Features for Fibrosarcoma

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Sources:
46OMIM
See all sources

Clinical features from OMIM:

117600

Clinical synopsis from OMIM:

117600

Drugs & Therapeutics for Fibrosarcoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Fibrosarcoma

Drug clinical trials:

Search ClinicalTrials for Fibrosarcoma

Search NIH Clinical Center for Fibrosarcoma

Search CenterWatch for Fibrosarcoma

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Fibrosarcoma

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Anatomical Context for Fibrosarcoma

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32MalaCards
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MalaCards organs/tissues related to Fibrosarcoma:

32
Bone, Breast, Colon, Lung, Heart, T cells, Liver, Ovary, Thyroid, Kidney, Endothelial, Pituitary, Pancreas, Monocytes, Myeloid, Skin, Brain, Tongue, Thymus, Lymph node, Nk cells

Animal Models for Fibrosarcoma or affiliated genes

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36MGI
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Publications for Fibrosarcoma

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Sources:
50PubMed
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Articles related to Fibrosarcoma:

(show top 50)    (show all 767)
idTitleAuthorsYear
1
Physalin A induces apoptotic cell death and protective autophagy in HT1080 human fibrosarcoma cells. (23647462)
2013
2
Congenital fibrosarcoma of the bowel: Sonographic description of a rare case of neonatal intestinal obstruction. (24281989)
2013
3
Anti-metastatic activity of biologically synthesized gold nanoparticles on human fibrosarcoma cell line HT-1080. (23711787)
2013
4
Congenital fibrosarcoma and history of prenatal exposure to petroleum derivatives. (22945410)
2012
5
Beta cell nuclear musculoaponeurotic fibrosarcoma oncogene family A (MafA) is deficient in type 2 diabetes. (22847061)
2012
6
Adult fibrosarcoma of the wrist: a case report. (22689150)
2012
7
Radiation-induced fibrosarcoma after radiotherapy for osteosarcoma in the mandibular condyle. (23172499)
2012
8
Fibrosarcoma arising from a burn scar. (21865123)
2011
9
Schistosoma mansoni U6 gene promoter-driven short hairpin RNA induces RNA interference in human fibrosarcoma cells and schistosomules. (21447344)
2011
10
Gene gun-mediated skin transfection with FL gene suppresses the growth of murine fibrosarcoma. (21372485)
2011
11
Endobronchial fibrosarcoma presenting as recurrent left-sided pneumonia. (21560264)
2011
12
Prenatal management of congenital infantile fibrosarcoma: unexpected outcome. (21618315)
2011
13
Giant primary pulmonary fibrosarcoma. (20578405)
2010
14
Synergistic effects of sonoporation and taurolidin/TRAIL on apoptosis in human fibrosarcoma. (20870344)
2010
15
Cytology of sclerosing epithelioid fibrosarcoma in pleural effusion. (20091700)
2010
16
Immunoexpression of Ki67, proliferative cell nuclear antigen, and Bcl-2 proteins in a case of ameloblastic fibrosarcoma. (21074695)
2010
17
Infantile fibrosarcoma successfully treated with chemotherapy, with occurrence of calcifying aponeurotic fibroma and pleomorphic/spindled celled lipoma at the site 12 years later. (19648795)
2009
18
Multiple bone metastasis of sclerosing epithelioid fibrosarcoma 12 years after initial surgery-increasing ki-67 labeling index. (19343182)
2009
19
Infantile fibrosarcoma: clinical and histologic responses to cytotoxic chemotherapy. (19340853)
2009
20
Metastatic hepatocellular carcinoma and subcutaneous fibrosarcoma in a black-headed gull (Larus ridibundus). (19202174)
2009
21
An unusual presentation of infantile fibrosarcoma in a male newborn. (19067284)
2009
22
Functional in vivo optical imaging of tumor angiogenesis, growth, and metastasis prevented by administration of anti-human VEGF antibody in xenograft model of human fibrosarcoma HT1080 cells. (19719773)
2009
23
Caspase inhibition augmented oridonin-induced cell death in murine fibrosarcoma l929 by enhancing reactive oxygen species generation. (18818479)
2008
24
Human tissue factor pathway inhibitor-2 induces caspase-mediated apoptosis in a human fibrosarcoma cell line. (18401718)
2008
25
Myeloid suppressor cell-associated immune dysfunction in CSA1M fibrosarcoma tumor-bearing mice. (17433038)
2007
26
Re: low grade malignant fibrosarcoma of the dental follicle of an unerupted third molar clinical evidence of any follicular lesion. (17448666)
2007
27
Combined effects of treatment with trientine, a copper-chelating agent, and x-irradiation on tumor growth in transplantation model of a murine fibrosarcoma. (17984591)
2007
28
Congenital infantile fibrosarcoma: a masquerader of ulcerated hemangioma. (16918626)
2006
29
Immunohistochemical study of STAT3 expression in feline injection-site fibrosarcomas. (16423575)
2006
30
Immune phenomena involved in the in vivo regression of fibrosarcoma cells expressing cell-associated IL-1alpha. (16707560)
2006
31
Infantile rhabdomyofibrosarcoma: a distinct variant or a missing link between fibrosarcoma and rhabdomyosarcoma? (16763362)
2006
32
Synchronous fibrosarcoma and medullary thyroid cancer in a man with AIDS. (17023794)
2006
33
Carboxylated chitooligosaccharides (CCOS) inhibit MMP-9 expression in human fibrosarcoma cells via down-regulation of AP-1. (17020790)
2006
34
The augmentation of TNFalpha-induced cell death in murine L929 fibrosarcoma by the pan-caspase inhibitor Z-VAD-fmk through pre-mitochondrial and MAPK-dependent pathways. (16418768)
2005
35
Inflammatory myofibroblastic tumor (inflammatory fibrosarcoma) of the pancreas: a case report. (15816492)
2005
36
Response of DNA repair enzymes in murine fibrosarcoma, lymphosarcoma and ascites cells following gamma irradiation. (14646226)
2003
37
Metastatic secondary fibrosarcoma of bone responsive to repeated courses of Ifosfamide and associated with hypoglycemia. (18521374)
2003
38
Ral promotes anchorage-independent growth of a human fibrosarcoma, HT1080. (11162603)
2001
39
ETV6-NTRK3 gene fusion in metastasizing congenital fibrosarcoma. (10918240)
2000
40
Cyclic AMP-regulated synthesis of the tissue inhibitors of metalloproteinases suppresses the invasive potential of the human fibrosarcoma cell line HT1080. (7796421)
1995
41
Primary cerebral fibrosarcomas. Clinicopathologic study and review of the literature. (8242554)
1993
42
Studies on the intracellular degradation of newly synthesized collagen in 3-methylcholanthrene induced fibrosarcoma cells. (1522755)
1992
43
Human colon carcinoma, fibrosarcoma and leukemia cell lines produce tumor-associated trypsinogen. (1995487)
1991
44
Deletion of part of the short arm of chromosome 17 in a congenital fibrosarcoma. (2204476)
1990
45
Complete response of congenital fibrosarcoma to chemotherapy. (2878294)
1986
46
Poorly differentiated fibrosarcoma (spindle cell sarcoma) involving the temporal bone. (3785903)
1986
47
Definitions of osteosarcoma, chondrosarcoma, and fibrosarcoma of bone. (6930319)
1980
48
Central fibrosarcoma of bone. Report of a case. (452904)
1979
49
Fibrosarcoma of bone. A study of 114 cases. (612638)
1977
50
Nevoid basal cell carcinoma syndrome with associated fibrosarcoma of the maxilla. Report of a case. (5641334)
1968

Genetic Variations for Fibrosarcoma

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Expression for genes affiliated with Fibrosarcoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Fibrosarcoma

Search GEO for disease gene expression data for Fibrosarcoma.

Pathways for genes affiliated with Fibrosarcoma

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49PharmGKB, 37NCBI BioSystems Database, 51QIAGEN, 4Cell Signaling Technology, 12EMD Millipore, 53Reactome
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Pathways related to Fibrosarcoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
111.0MAFG, MAFA, MAFK, MAF, MAFF, MAFB
2
Hide members
10.8TFPI2, MMP2, MMP9, MMP14
310.8MMP9, PDGFRA, MMP2
4
Cell adhesion ECM remodeling
Hide members
10.8MMP14, MMP9, MMP2
510.8MMP9, MMP2, MMP14
6
Hide members
10.7MMP14, MMP2

Compounds for genes affiliated with Fibrosarcoma

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44Novoseek, 59Tocris Bioscience, 24HMDB, 11DrugBank, 2BitterDB
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Compounds related to Fibrosarcoma according to GeneCards/GeneDecks:

(show all 44)
idCompoundScoreTop Affiliating Genes
1vegf4411.6PDGFRA, STC1, EGR1, NTRK3, ETV6, MMP14
2matrigel4411.5TFPI2, EGR1, NTRK3, MMP14, MMP2, MMP9
3leucine4411.4EGR1, MAFG, MAFK, MAF, MAFF, MMP14
4phosphatidylinositol4411.4PDGFRA, EGR1, NTRK3, MMP14, MMP2, MMP9
5tgf beta14411.4PDGFRA, EGR1, MMP14, MMP2, MMP9
6ag 14784411.3MMP9, MMP2, MMP14, EGR1
7aspartate4411.3PDGFRA, TFPI2, NTRK3, MMP2, MMP9
8sp 60012544 5912.2MMP9, MMP2, MMP14, EGR1
9cytochalasin d44 5912.2EGR1, MMP14, MMP2, MMP9
10flavanol4411.2MMP9, MMP2, MMP14
11curcumin4411.2EGR1, MMP14, MMP2, MMP9
12prinomastat4411.2MMP14, MMP2, MMP9
13retinoic acid44 2412.2PDGFRA, EGR1, NTRK3, ETV6, MMP2, MMP9
14ilomastat4411.2MMP9, MMP2, MMP14
15uk 3833675911.2MMP14, MMP2, MMP9
16gi 254023x5911.2MMP14, MMP2, MMP9
17gm 60015911.2MMP14, MMP2, MMP9
18phorbol-12-myristate4411.2EGR1, MMP14, MMP9
19hydroxamate4411.2MMP14, MMP2, MMP9
20marimastat44 59 1113.1MMP9, MMP2, MMP14
21tbhq4411.1MAF, MAFK, MAFG
22ribonucleic acid4411.1EGR1, MMP14, MMP2, MMP9
231,10-phenanthroline44 212.1MMP9, MMP2, MMP14
24batimastat44 59 1113.1MMP9, MMP2, MMP14
2512-o-tetradecanoylphorbol 13-acetate4411.1EGR1, MMP14, MMP2, MMP9
26cgs-27023a4411.0MMP2, MMP9
27methyl selenol4411.0MMP2, MMP9
28col 34411.0MMP2, MMP9
29pdtc4411.0MMP9, MMP2, MAFG
30trapidil4411.0MMP9, MMP2
31lercanidipine44 1112.0MMP9, MMP2
32tranilast4411.0MMP9, MMP2
33estrogen4411.0ING1
34tetracycline44 1111.9MMP14, MMP2, MMP9
35gelfoam4410.9MMP9, MMP2
36pd 98,0594410.9EGR1, MMP14, MMP2, MMP9
37cilomilast4410.9MMP9, MMP2
38latanoprost44 1111.9MMP9, MMP2
39cycloheximide4410.9NTRK3
40ly2940024410.8MMP9, MMP2, MMP14, EGR1
41grgdsp4410.8MMP2, MMP14
42p0024410.8MMP9, MMP14, TFPI2
43wortmannin4410.7EGR1, MMP14, MMP2, MMP9
44phorbol4410.5MMP9, MMP2, EGR1

GO Terms for genes affiliated with Fibrosarcoma

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16Gene Ontology
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Biological processes related to Fibrosarcoma according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1embryo implantationGO:00756610.9STC1, MMP2, MMP9
2collagen catabolic processGO:03057410.8MMP2, MMP14, MMP9
3regulation of epidermal cell differentiationGO:04560410.8MAFG, MAFF
4positive regulation of cell migrationGO:03033510.8MMP14, NTRK3, PDGFRA
5extracellular matrix disassemblyGO:02261710.8MMP9, MMP2, MMP14
6extracellular matrix organizationGO:03019810.7PDGFRA, MMP14, MMP2, MMP9
7transcription from RNA polymerase II promoterGO:00636610.5EGR1, NFE2L3, MAF, MAFF

Molecular functions related to Fibrosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1sequence-specific DNA bindingGO:04356511.2EGR1, ETV6, MAFB, MAFF, MAF, MAFK
2sequence-specific DNA binding transcription factor activityGO:00370011.1MMP14, MAFK, EGR1, ETV6, NFE2L3, MAFA
3metalloendopeptidase activityGO:00422210.8MMP9, MMP14, MMP2

Products for genes affiliated with Fibrosarcoma

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Sources for Fibrosarcoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet