MCID: FBR017
MIFTS: 63

Fibrosarcoma malady

Rare diseases, Bone diseases, Cancer diseases categories
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Summaries for Fibrosarcoma

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65Wikipedia, 47OMIM, 33MalaCards
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Wikipedia:65 Fibrosarcoma (fibroblastic sarcoma) is a malignant mesenchymal tumour derived from fibrous connective... more...

MalaCards: Fibrosarcoma, also known as fibrosarcoma of the soft tissue, is related to congenital fibrosarcoma and congenital mesoblastic nephroma. An important gene associated with Fibrosarcoma is ETV6 (ets variant 6), and among its related pathways are Factors involved in megakaryocyte development and platelet production and Matrix Metalloproteinases. The drug dacarbazine and the compounds flavanol and prinomastat have been mentioned in the context of this disorder. Affiliated tissues include bone, breast and colon, and related mouse phenotypes are craniofacial and renal/urinary system.

Description from OMIM:47 117600

Aliases & Classifications for Fibrosarcoma

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8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 49Orphanet, 47OMIM, 62UMLS, 58SNOMED-CT, 35MeSH, 40NCIt, 36MESH via Orphanet, 59SNOMED-CT via Orphanet, 63UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Bone diseases


Characteristics (Orphanet epidemiological data):

49
fibrosarcoma:
Age of onset: Variable


Aliases & Descriptions:

fibrosarcoma 8 43 10 45 49 47 62
fibrosarcoma of the soft tissue 8
fibrosarcoma of soft tissue 8
neoplasms, fibrous tissue 62
fibrous tissue neoplasm 8
fibrocytic tumor 8


External Ids:

Disease Ontology8 DOID:3355
MeSH35 D005354
NCIt40 C3043
OMIM47 117600
SNOMED-CT58 53654007, 443250000
MESH via Orphanet36 D005354
SNOMED-CT via Orphanet59 53654007
UMLS via Orphanet63 C0016057

Related Diseases for Fibrosarcoma

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17GeneCards, 18GeneDecks
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Diseases in the Fibrosarcoma family:

Congenital Fibrosarcoma Adult Fibrosarcoma

Diseases related to Fibrosarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 144)
idRelated DiseaseScoreTop Affiliating Genes
1congenital fibrosarcoma31.3GOLGA6A, GOLGA6B, ETV6
2congenital mesoblastic nephroma30.2NTRK3, ETV6
3leukemia30.1HMMR, PDGFRA, NTRK3, STC1, ETV6, APRT
4adenocarcinoma30.0NTRK3, MMP14, MMP2, TFPI2, SPINK1
5hepatocellular carcinoma29.7SPINK1, TFPI2, MMP2, MMP14, STC1, PDGFRA
6breast cancer29.7MMP2, MMP14, ETV6, STC1, NTRK3, HMMR
7fibrosarcoma of bone10.6
8sarcoma10.3
9osteosarcoma10.3
10breast fibrosarcoma10.3
11fibroma10.3
12fibrous histiocytoma10.3
13adult fibrosarcoma10.3
14histiocytoma10.3
15mesoblastic nephroma10.3
16heart fibrosarcoma10.2
17small bowel fibrosarcoma10.2
18dermatofibrosarcoma10.2
19dermatofibrosarcoma protuberans10.2
20inflammatory myofibroblastic tumor10.2
21hypoxia10.2
22liver fibrosarcoma10.2
23central nervous system fibrosarcoma10.2
24chondrosarcoma10.2
25hemangioma10.2
26liposarcoma10.2
27rhabdomyosarcoma10.2
28thyroiditis10.2
29parotitis10.1SPINK1
30hypoglycemia10.1
31cerebritis10.1
32conventional fibrosarcoma10.1
33kidney fibrosarcoma10.1
34basal cell carcinoma10.1
35fasciitis10.1
36pediatric fibrosarcoma10.1
37desmoid tumor10.1
38endotheliitis10.1
39chronic myelomonocytic leukemia10.1PDGFRA, ETV6
40mastocytosis10.1PDGFRA, NTRK3
41myeloproliferative disorder10.1ETV6, NTRK3, PDGFRA
42keratitis10.1MMP2
43serous cystadenocarcinoma10.1MMP14, MMP2
44peripheral t-cell lymphoma10.1ETV6, PDGFRA
45abdominal aortic aneurysm10.1MMP14, MMP2
46endometriosis10.0MMP2, MMP14, PDGFRA
47brain cancer10.0PDGFRA, NTRK3, MMP14, TFPI2
48chronic myeloid leukemia10.0PDGFRA, NTRK3, ETV6
49malignant glioma10.0MMP2, MMP14, PDGFRA
50cervical cancer10.0SPINK1, MMP2, MMP14

Graphical network of the top 20 diseases related to Fibrosarcoma:



Diseases related to fibrosarcoma

Symptoms for Fibrosarcoma

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47OMIM
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Symptoms by clinical synopsis from OMIM:

117600

Clinical features from OMIM:

117600

Drugs & Therapeutics for Fibrosarcoma

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Fibrosarcoma

Search NIH Clinical Center for Fibrosarcoma

Inferred drug relations via UMLS62/NDF-RT41:

Genetic Tests for Fibrosarcoma

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Anatomical Context for Fibrosarcoma

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33MalaCards
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MalaCards organs/tissues related to Fibrosarcoma:

33
Bone, Breast, Colon, Lung, Heart, T cells, Ovary, Liver, Thyroid, Kidney, Endothelial, Pancreas, Tongue, Monocytes, Myeloid, Skin, Brain, Pituitary, Thymus, Nk cells, Lymph node

Animal Models for Fibrosarcoma or affiliated genes

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37MGI
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Publications for Fibrosarcoma

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52PubMed
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Articles related to Fibrosarcoma:

(show top 50)    (show all 760)
idTitleAuthorsYear
1
Congenital infantile fibrosarcoma of the lip. (24138391)
2014
2
Physalin A induces apoptotic cell death and protective autophagy in HT1080 human fibrosarcoma cells. (23647462)
2013
3
Congenital fibrosarcoma of the bowel: Sonographic description of a rare case of neonatal intestinal obstruction. (24281989)
2013
4
Inhibition of Growth and Induction of Apoptosis in Fibrosarcoma Cell Lines by Echinophora platyloba DC: In Vitro Analysis. (23365566)
2013
5
Intraosseous fibrosarcoma of maxilla in an HIV patient. (22208447)
2012
6
Mediators of receptor tyrosine kinase activation in infantile fibrosarcoma: a Children's Oncology Group study. (22374738)
2012
7
Fibrosarcoma arising from a burn scar. (21865123)
2011
8
Chaotic neovascularization induced by aggressive fibrosarcoma cells overexpressing S-adenosylmethionine decarboxylase. (21134486)
2011
9
Anticancer effects of fullerene [C60] included in polyethylene glycol combined with visible light irradiation through ROS generation and DNA fragmentation on fibrosarcoma cells with scarce cytotoxicity to normal fibroblasts. (21542456)
2011
10
Molecular cytogenetics reveals complex karyotype in apparent t(8;13) therapy-related acute myeloid leukemia M2 after fibrosarcoma. (21329977)
2011
11
Giant primary pulmonary fibrosarcoma. (20578405)
2010
12
A rare case of locally advanced fibrosarcoma of diaphysal humerus managed successfully with limb-sparing procedures after neoadjuvant chemotherapy. (20819211)
2010
13
Zoledronic acid inhibits proliferation of human fibrosarcoma cells with induction of apoptosis, and shows combined effects with other anticancer agents. (20514467)
2010
14
Abdominal fibrosarcoma associated with a retained surgical swab in a dog. (20096417)
2010
15
Cellular mesoblastic nephroma (infantile renal fibrosarcoma): institutional review of the clinical, diagnostic imaging, and pathologic features of a distinctive neoplasm of infancy. (19629465)
2009
16
Congenital fibrosarcoma with a novel complex 3-way translocation t(12;15;19) and unusual histologic features. (18657299)
2008
17
Frzb, a secreted Wnt antagonist, decreases growth and invasiveness of fibrosarcoma cells associated with inhibition of Met signaling. (18451162)
2008
18
Opposing effects of fibrosarcoma cell-derived IL-1 alpha and IL-1 beta on immune response induction. (18412246)
2008
19
Vaginal fibrosarcoma in a cow. (21851697)
2007
20
A unique fibrous tumor of the ovary: fibrosarcoma or mitotically active cellular fibroma? (18214045)
2007
21
Sclerosing epithelioid fibrosarcoma of the pituitary. (18097772)
2007
22
Dynamic contrast enhanced MRI of mouse fibrosarcoma using small-molecular and novel macromolecular contrast agents. (18061121)
2007
23
Junctional adhesion molecule-C promotes metastatic potential of HT1080 human fibrosarcoma. (17227766)
2007
24
Non-apoptotic programmed cell death induced by a copper(II) complex in human fibrosarcoma cells. (16733666)
2006
25
Stable expression of a heterogeneous gene introduced via gene targeting into the HPRT locus of human fibrosarcoma cells. (16807926)
2006
26
Inhibitory effects of caffeic acid phenethyl ester on cancer cell metastasis mediated by the down-regulation of matrix metalloproteinase expression in human HT1080 fibrosarcoma cells. (16214327)
2006
27
Congenital infantile fibrosarcoma: a masquerader of ulcerated hemangioma. (16918626)
2006
28
Unexpected effect of matrix metalloproteinase down-regulation on vascular intravasation and metastasis of human fibrosarcoma cells selected in vivo for high rates of dissemination. (16322244)
2005
29
Coxofemoral arthroscopy and total hip arthroplasty for management of intermediate grade fibrosarcoma in a dog. (15720595)
2005
30
Inhibitory effects of adrenomedullary hormone on the induction and growth of fibrosarcoma by methylcholanthrene. (15855881)
2005
31
99mTc-MDP uptake in fibrosarcoma in a cat. (15977148)
2005
32
Peripheral-type benzodiazepine receptor (PBR) and PBR drug ligands in fibroblast and fibrosarcoma cell proliferation: role of ERK, c-Jun and ligand-activated PBR-independent pathways. (15130769)
2004
33
Congenital fibrosarcoma with metastasis in a fetus. (15022058)
2004
34
Plakoglobin is a new target gene of histone deacetylase in human fibrosarcoma HT1080 cells. (14661058)
2004
35
Giant fibrosarcoma arising in dermatofibrosarcoma protuberans on the scalp during pregnancy. (12614428)
2003
36
Apoptosis induced by butyrate is independent of Jak/STAT signaling in a fibrosarcoma cell line. (12589807)
2003
37
Effects of tea polyphenols on the invasion and matrix metalloproteinases activities of human fibrosarcoma HT1080 cells. (10794635)
1999
38
Highly activated matrix metalloproteinase-2 secreted from clones of metastatic lung nodules of nude mice injected with human fibrosarcoma HT1080. (10656606)
1999
39
Overexpression of manganese superoxide dismutase selectively modulates the activity of Jun-associated transcription factors in fibrosarcoma cells. (9393747)
1997
40
Suppression of transformed phenotypes of human fibrosarcoma cells by overexpression of recombinant fibronectin. (8813154)
1996
41
Intrathoracic congenital fibrosarcoma. A case report. (7608883)
1995
42
Congenital fibrosarcoma masquerading as lymphatic malformation: report of two cases. (7722837)
1995
43
Single-base deletion induced by benzo[a]pyrene diol epoxide at the adenine phosphoribosyltransferase locus in human fibrosarcoma cell lines. (7510848)
1994
44
Primary rhabdomyosarcoma of the iliac bone in an adult: a case mimicking fibrosarcoma. (8212536)
1993
45
Interaction of topoisomerase I inhibitors with radiation in cis-diamminedichloroplatinum(II)-sensitive and -resistant cells in vitro and in the FSAIIC fibrosarcoma in vivo. (8416195)
1993
46
Congenital fibrosarcoma of the forearm. A case report. (3957990)
1986
47
Metastatic spread of fibrosarcoma of bone; A report on forty-nine cases, and a comparison with osteosarcoma. (1071090)
1976
48
Pancreaticoduodenectomy in the treatment of congenital fibrosarcoma of the duodenum. (1185470)
1975
49
Ultrastructure of congenital fibrosarcoma. (5483658)
1970
50
Congenital fibrosarcoma. (13095275)
1953

Variations for Fibrosarcoma

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Expression for genes affiliated with Fibrosarcoma

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Fibrosarcoma

Search GEO for disease gene expression data for Fibrosarcoma.

Pathways for genes affiliated with Fibrosarcoma

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50PathCards, 55Reactome, 38NCBI BioSystems Database, 53QIAGEN, 51PharmGKB
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Pathways related to Fibrosarcoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8MAFG, MAFF, MAFK
2
Show member pathways
9.6TFPI2, MMP2, MMP14
39.1MAFB, MAFG, MAFA, MAFF, MAF, MAFK

Compounds for genes affiliated with Fibrosarcoma

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45Novoseek, 61Tocris Bioscience, 51PharmGKB, 11DrugBank
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Compounds related to Fibrosarcoma according to GeneCards/GeneDecks:

(show all 17)
idCompoundScoreTop Affiliating Genes
1flavanol4510.3MMP14, MMP2
2prinomastat4510.3MMP14, MMP2
3ilomastat4510.3MMP14, MMP2
4grgdsp4510.3MMP14, MMP2
5uk 3833676110.2MMP2, MMP14
6gi 254023x6110.1MMP2, MMP14
7imatinib45 51 1112.1PDGFRA, NTRK3, ETV6
8gm 60016110.1MMP2, MMP14
9tbhq4510.1MAFG, MAF, MAFK
10tgf beta14510.0MMP2, MMP14, PDGFRA
11hydroxamate459.9MMP14, MMP2
12marimastat45 61 1111.7MMP14, MMP2
13matrigel459.7TFPI2, MMP2, MMP14, NTRK3
14leucine459.7MMP14, MAFK, MAF, MAFF, MAFG
15aspartate459.5TFPI2, MMP2, NTRK3, PDGFRA
16vegf459.4MMP2, MMP14, ETV6, STC1, NTRK3, PDGFRA
17tyrosine459.1MMP14, ETV6, NTRK3, PDGFRA, HMMR, MMP2

GO Terms for genes affiliated with Fibrosarcoma

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16Gene Ontology
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Biological processes related to Fibrosarcoma according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1regulation of epidermal cell differentiationGO:04560410.2MAFG, MAFF
2positive regulation of cell migrationGO:03033510.0PDGFRA, NTRK3, MMP14
3face morphogenesisGO:0603259.9PDGFRA, MMP2
4embryo implantationGO:0075669.9STC1, MMP2
5transcription from RNA polymerase II promoterGO:0063669.7ETV6, MAF, MAFF, NFE2L3
6angiogenesisGO:0015259.5MMP14, MMP2, AIMP1
7blood coagulationGO:0075969.3TFPI2, MAFK, MAFF, MAFG

Molecular functions related to Fibrosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transmembrane receptor protein tyrosine kinase activityGO:00471410.1PDGFRA, NTRK3
2sequence-specific DNA bindingGO:0435658.6NFE2L3, ETV6, MAFK, MAF, MAFF, MAFA
3sequence-specific DNA binding transcription factor activityGO:0037008.2MMP14, ETV6, MAFK, MAF, MAFF, MAFA

Products for genes affiliated with Fibrosarcoma

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Sources for Fibrosarcoma

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet