Fibrosarcoma malady

Wikipedia: Fibrosarcoma (fibroblastic sarcoma) is a malignant mesenchymal tumour derived from fibrous connective...⁴⁴ more...

MalaCards: Fibrosarcoma, also known as fibrosarcoma of soft tissue, is related to congenital fibrosarcoma and fibrosarcoma of bone. An important gene associated with Fibrosarcoma is ETV6 (ets variant 6), and among its related pathways are UPA-UPAR Pathway and Integrin Pathway. The drug dacarbazine and the compounds ascorbic acid and lipid have been mentioned in the context of this disorder. Affiliated tissues include lymph node, brain and heart, and related mouse phenotypes are hematopoietic system and craniofacial.

Aliases & Descriptions:

fibrosarcoma 6 30 8 32 43 fibrosarcoma of soft tissue 6 8 fibrosarcoma (morphologic abnormality) 6 fibrosarcoma of the soft tissue 6

neoplasms, fibrous tissue 43 fibrous tissue neoplasm 6 fibrocytic tumor 6

Diseases related to fibrosarcoma by text searches and GeneDecks gene sharing:

(show top 50)    (show all 793)

id	Related Disease	Score	Top Affiliating Genes
1	congenital fibrosarcoma	32.5	MUSK, GOLGA6A, GOLGA6B, ETV6, TPM3, TEC
2	fibrosarcoma of bone	32.5	KIT, KDR, CHD1L, CDKN2A, ING1, PDGFRA
3	carcinoma	30.4	PIK3CG, LRRC2, RECK, KIT, KIF23, KITLG
4	squamous cell carcinoma	29.5	RECK, VTN, RB1, SETD2, SERPINB2, VIM
5	fibrous histiocytoma	28.8	VIM, FUS, CD34, F13A1, CTSB, ACTC1
6	dermatofibrosarcoma	28.7	KIT, VIM, MUC1, S100A1, CD34, MMP1
7	dermatofibrosarcoma protuberans	28.7	KIT, VIM, MUC1, S100A1, CD34, MMP1
8	congenital mesoblastic nephroma	28.1	VIM, MDM2, IGF2, ETV6, SSX2B, NTRK3
9	teratoma	28.0	KIT, VIM, BCL2, JUN, CDKN2A, CA9
10	sarcoma	27.7	PIK3CG, RECK, KIT, KITLG, VTN, RB1
11	rhabdomyosarcoma	26.8	KITLG, RB1, VIM, VEGFA, MYOD1, BMP6
12	colon carcinoma	26.6	PIK3CG, KIT, KITLG, VTN, SETD2, SERPINB2
13	hypoxia	26.5	PIK3CG, RECK, KIT, KITLG, VTN, RB1
14	dna topoisomerase i	26.5	PARP1, JUN, CDK6, CDKN2A, CDK4, FGF2
15	immunodeficiency	26.2	BMP6, PARP1, CIITA, CD4, ITGA4, INHA
16	hepatitis	25.9	PIK3CG, KIT, KITLG, VTN, RB1, SETD2
17	hypoglycemia	25.8	PIK3CG, SETD2, VIM, VEGFA, CIITA, JUN
18	leukemia	25.6	PIK3CG, RECK, KIT, KITLG, VTN, RB1
19	leiomyosarcoma	25.6	KIT, RB1, VIM, VEGFA, MYOD1, BCL2
20	liposarcoma	25.6	KIT, RB1, VIM, VEGFA, PARP1, KDR
21	adenocarcinoma	25.4	PIK3CG, RECK, KIT, KITLG, VTN, RB1
22	histiocytoma	24.4	KITLG, RB1, VIM, VEGFA, MYOD1, BCL2
23	osteosarcoma	24.3	PIK3CG, RECK, KIT, VTN, RB1, SETD2
24	malignant fibrous histiocytoma	24.1	KITLG, RB1, VIM, VEGFA, MYOD1, BCL2
25	severe combined immunodeficiency	23.6	LRRC2, KITLG, VHL, VEGFA, KDR, BCL2
26	combined immunodeficiency	23.6	LRRC2, KITLG, VHL, VEGFA, KDR, BCL2
27	colon adenocarcinoma	23.5	VTN, VEGFA, VCAN, MYB, BMP6, CLU
28	conjunctivitis	23.2	KITLG, RB1, VIM, VEGFA, MYB, BCL2
29	cholesterol	22.8	PIK3CG, RECK, KITLG, VTN, RB1, SERPINE1
30	fibromatosis	15.1	KIT, RB1, SERPINE1, VIM, S100A1, CD36
31	hepatic fibrosis renal cysts mental retardation	15.1	VTN, SERPINE1, BMP6, CD36, ITGB1, MMP1
32	periodontal disease	14.9	SERPINB2, CD36, CD14, ITGB1, MMP1, MMP13
33	liver cirrhosis	14.8	VTN, SERPINB2, RAF1, CD14, CD34, ITGB1
34	pediatric cns embryonal cell carcinoma	14.8	KIT, KITLG, MYOD1, LAMB1, JUN, ITGB1
35	refractive error	14.7	MMP1, MMP13, MMP14, MMP2, MMP3, MMP9
36	abdominal aortic aneurysm	14.7	MMP1, MMP13, MMP14, MMP2, MMP3, MMP9
37	factor v leiden thrombophilia	14.6	RECK, SETD2, SERPINE1, VHL, JAK2, CD34
38	keratoconus	14.6	VIM, S100A1, ITGA6, MMP1, MMP14, MMP2
39	sm-ahnmd	14.5	KIT, KITLG, RAC2, JAK2, TPSAB1, NTRK3
40	myeloproliferative disorder	14.5	KIT, KITLG, KDR, JUNB, JAK2, FGF2
41	glanzmann's thrombasthenia	14.5	RECK, VTN, CD9, ITGA2, FN1, F9
42	neurilemmoma	14.4	KIT, VIM, RAC1, MUC1, S100A1, CD34
43	lipoma	14.4	SERPINE1, VIM, S100A1, FUS, CDKN2A, CD34
44	gonococcal synovitis	14.4	PIK3CG, RECK, KITLG, VTN, SETD2, SERPINB2
45	perivascular epithelioid cell tumor	14.4	KIT, KITLG, VIM, MUC1, S100A1, CDKN2A
46	endometrial stromal sarcoma	14.4	KIT, VIM, INHA, PDGFRA, PDGFRB, ACTC1
47	aneurysm disease	14.4	MMP1, MMP14, MMP2, MMP3, MMP9, CCL2
48	mastocytosis	14.4	KIT, KITLG, VIM, RAC2, CMA1, BCL2
49	hypertrophy of breast	14.4	PIK3CG, SETD2, MYOD1, BMP6, RAF1, RAC1
50	lung carcinoma	14.4	PIK3CG, RECK, RB1, SETD2, SERPINB2, VHL

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 dacarbazine

MalaCards organs/tissues related to fibrosarcoma:

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MGI Mouse Phenotypes related to fibrosarcoma:

²⁵ (show all 28)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system phenotype	MP:0005397	11.7	KIT, SERPINB2, VHL, RAC2, BCL2, BCL2L1
2	craniofacial phenotype	MP:0005382	11.4	KIT, KITLG, ITGA4, MKKS, IL17A, FBLN1
3	nervous system phenotype	MP:0003631	11.3	RECK, KIT, KITLG, RB1, NAB2, VCAN
4	embryogenesis phenotype	MP:0005380	11.2	RECK, KIT, SETD2, VIM, VHL, MYB
5	immune system phenotype	MP:0005387	11.2	KIT, SERPINB2, VIM, MYB, RAF1, RAC2
6	renal/urinary system phenotype	MP:0005367	11.1	KIT, VHL, CLU, BCL2, FYN, JUNB
7	growth/size phenotype	MP:0005378	11.0	PIK3CG, RECK, KIT, KITLG, RB1, SETD2
8	other phenotype	MP:0005395	11.0	RECK, CLU, KDR, JAK2, CDKN2A, ITGA6
9	behavior/neurological phenotype	MP:0005386	11.0	KIT, RB1, VIM, NAB2, KDR, MUSK
10	respiratory system phenotype	MP:0005388	10.7	NAB2, MYOD1, MUSK, JAM3, CD14, MKKS
11	endocrine/exocrine gland phenotype	MP:0005379	10.7	FUS, JAM3, CDK6, ITGA3, INHA, IL2
12	limbs/digits/tail phenotype	MP:0005371	10.4	RECK, KIT, KITLG, RB1, VHL, VEGFA
13	normal phenotype	MP:0002873	10.3	VTN, NAB2, VHL, VEGFA, VCAN, MYB
14	reproductive system phenotype	MP:0005389	10.2	NAB2, VHL, VEGFA, MYOD1, LAMA1, FYN
15	mortality/aging	MP:0010768	9.9	RECK, KITLG, RB1, SETD2, SERPINB2, SERPINE1
16	homeostasis/metabolism phenotype	MP:0005376	9.7	PIK3CG, KIT, KITLG, VTN, RB1, SETD2
17	skeleton phenotype	MP:0005390	9.7	PIK3CG, RECK, KIT, KITLG, RB1, NAB2
18	cardiovascular system phenotype	MP:0005385	9.1	PIK3CG, RECK, KIT, KITLG, RB1, SETD2
19	integument phenotype	MP:0010771	8.9	PIK3CG, RECK, KIT, KITLG, RB1, NAB2
20	hearing/vestibular/ear phenotype	MP:0005377	8.7	KIT, KITLG, RB1, PARP1, BCL2, CDKN1A
21	tumorigenesis	MP:0002006	8.6	KIT, KITLG, RB1, SERPINE1, VHL, BCL2
22	liver/biliary system phenotype	MP:0005370	8.5	RECK, KIT, VHL, VEGFA, MYB, JUND
23	digestive/alimentary phenotype	MP:0005381	8.5	KIT, KITLG, RB1, VHL, VEGFA, BCL2
24	cellular phenotype	MP:0005384	8.4	PIK3CG, KIT, KITLG, RB1, VIM, NAB2
25	adipose tissue phenotype	MP:0005375	8.4	RB1, SERPINE1, MYOD1, BCL2, CDKN1A, CD36
26	no phenotypic analysis	MP:0003012	8.4	RB1, VEGFA, MYOD1, PARP1, MUC1, FYN
27	muscle phenotype	MP:0005369	8.2	PIK3CG, KIT, RB1, SERPINB2, VIM, VHL
28	vision/eye phenotype	MP:0005391	7.8	KIT, KITLG, RB1, VIM, VEGFA, RAF1

Articles related to fibrosarcoma:

(show top 50)    (show all 224)

id	Title	Authors	Year	Affiliating Genes
1	Silibinin activated p53 and induced autophagic death in human fibrosarcoma HT1080 cells via reactive oxygen species-p38 and c-Jun N- terminal kinase pathways. (21212516)	Duan W.J.... Ikejima T.	2011	TP53, MAPK1, JUN
2	Inhibition of the expression on MMP-2, 9 and morpholo gical changes via human fibrosarcoma cell line by 6,6'-bieckol from marine alga Ecklonia cava. (20132738)	Zhang C.... Kim S.K.	2010	MMP2
3	Mechanism of endothelial Rho/Rho kinase in extravasc ular Migration of fibrosarcoma cell (19968078)	Xin H.... Han Z.G.	2009	RHOD
4	Identification of integrins alpha6 and beta7 as c-Jun - and transformation-relevant genes in highly invasive fibrosarcoma cells. (19405119)	Kielosto M.... HAPlttAo E.	2009	JUN, ITGA6, CTSL1
5	Specific roles of Rac1 and Rac2 in motile functions o f HT1080 fibrosarcoma cells. (19555660)	Niggli V.... Affentranger S.	2009	RAC2, RAC1
6	Functional regulation of endothelial Myosin light chain kinase in extravascular migration of fibrosarcoma cells. (19363821)	Xin H.... Han Z.G.	2009	MYLK3
7	Frzb, a secreted Wnt antagonist, decreases growth and invasiveness of fibrosarcoma cells associated with inhibition of Met signaling. (18451162)	Guo Y.... Hoang B.H.	2008	MET, FRZB
8	Rottlerin induces autophagy and apoptotic cell death through a PKC-delta-independent pathway in HT1080 human fibrosarcoma cells: the protective role of autophagy in apoptosis. (18424913)	Song K.S.... Hwang B.D.	2008	PRKCD
9	Dimerization of endogenous MT1-MMP is a regulatory step in the activation of the 72-kDa gelatinase MMP-2 on fibroblasts and fibrosarcoma cells. (18627313)	Ingvarsen S.... Engelholm L.H.	2008	MMP2, MMP14
10	Collagen-binding domains of gelatinase A and thrombospondin-derived peptides impede endocytic clearance of active gelatinase A and promote HT1080 fibrosarcoma cell invasion. (18222489)	Robinet A.... Bellon G.	2008	MMP2, THBS1
11	Slit2 inhibits growth and metastasis of fibrosarcoma and squamous cell carcinoma. (19048120)	Kim H.K.... Xu H.	2008	CDH2, CDK6, SLIT2
12	Down-regulation of phosphoglucose isomerase/autocrine motility factor results in mesenchymal-to-epithelial transition of human lung fibrosarcoma cells. (17483335)	Funasaka T.... Raz A.	2007	GPI
13	Fibrosarcoma of the jaws: two cases of primary tumors with intraosseous growth. (17695417)	Angiero F.... Stefani M.	2007	VIM, MUC1, S100A1
14	Histopathology of hemangiosarcomas in mice and hamsters and liposarcomas/fibrosarcomas in rats associated with PPAR agonists. (18098039)	Hardisty J.F.... Tellier P.A.	2007	PPARA
15	Sulfated glucosamine inhibits MMP-2 and MMP-9 expressions in human fibrosarcoma cells. (17498959)	Rajapakse N.... Kim S.K.	2007	MMP2, MMP9
16	Down-regulation of phosphoglucose isomerase/autocrine motility factor expression sensitizes human fibrosarcoma cells to oxidative stress leading to cellular senescence. (17925402)	Funasaka T.... Raz A.	2007	GPI
17	Down regulation of 3p genes, LTF, SLC38A3 and DRR1, upon growth of human chromosome 3-mouse fibrosarcoma hybrids in severe combined immunodeficiency mice. (16432833)	Kholodnyuk I.D.... Imreh S.	2006	LTF, SLC38A3, FAM107A
18	Elevation of radiolabelled thymidine uptake in RIF-1 fibrosarcoma and HT29 colon adenocarcinoma cells after treatment with thymidylate synthase inhibitors. (16568206)	Yau K.... Aboagye E.	2006	TYMS
19	Inflammatory myofibroblastic tumors of the urinary tract: a clinicopathologic study of 46 cases, including a malignant example inflammatory fibrosarcoma and a subset associated with high-grade urothelial carcinoma. (17122505)	Montgomery E.A.... Epstein J.I.	2006	ALK
20	Activity-based protein profiling implicates urokinase activation as a key step in human fibrosarcoma intravasation. (16611636)	Madsen M.A.... Quigley J.P.	2006	PLAU, SERPINE1
21	Inhibitory effect of chitooligosaccharides on matrix metalloproteinase-9 in human fibrosarcoma cells (HT1080). (17091328)	Van Ta Q.... Kim S.K.	2006	MMP9
22	Stable expression of a heterogeneous gene introduced via gene targeting into the HPRT locus of human fibrosarcoma cells. (16807926)	Koyama Y.... Kusano K.	2006	HPRT1
23	Differential roles of Rho-kinase and myosin light chain kinase in regulating shape, adhesion, and migration of HT1080 fibrosarcoma cells. (16554034)	Niggli V.... Nievergelt A.	2006	MYLK3
24	Unexpected effect of matrix metalloproteinase down-regulation on vascular intravasation and metastasis of human fibrosarcoma cells selected in vivo for high rates of dissemination. (16322244)	Deryugina E.I.... Quigley J.P.	2005	MMP14
25	Malignant fibrous histiocytoma: pleomorphic sarcoma NOS or pleomorphic fibrosarcoma (15702318)	Meister P.	2005	DES, NOS2
26	Indication of a role of plasminogen activator inhibitor type I in protecting murine fibrosarcoma cells against apoptosis. (16270643)	Romer M.U.... Lademann U.	2005	SERPINE1
27	Focal adhesion kinase regulates syndecan-2-mediated tumorigenic activity of HT1080 fibrosarcoma cells. (16267014)	Park H.... Oh E.S.	2005	PTK2, PIK3CG, TIAM1
28	Reduction of experimental human fibrosarcoma lung metastasis in mice by adenovirus-mediated cystatin C overexpression in the host. (16204025)	Kopitz C.... KrA1ger A.	2005	CTSB, CST3
29	Response rate of fibrosarcoma cells to cytotoxic drugs on the expression level correlates to the therapeutic response rate of fibrosarcomas and is mediated by regulation of apoptotic pathways. (16001973)	Lehnhardt M.... Mueller O.	2005	CASP1
30	Plakoglobin is a new target gene of histone deacetylase in human fibrosarcoma HT1080 cells. (14661058)	Shim J.S.... Kwon H.J.	2004	HDAC9, JUP
31	Inducible expression of the gap junction protein connexin43 decreases the neoplastic potential of HT-1080 human fibrosarcoma cells in vitro and in vivo. (12203365)	King T.J.... Bertram J.S.	2002	GJA1
32	Inhibition of activator protein-1 binding activity and phosphatidylinositol 3-kinase pathway by nobiletin, a polymethoxy flavonoid, results in augmentation of tissue inhibitor of metalloproteinases-1 production and suppression of production of matrix metalloproteinases-1 and -9 in human fibrosarcoma HT-1080 cells. (11861377)	Sato T.... Ito A.	2002	MMP1, JUN, TIMP1
33	Hyaluronidase activation of c-Jun N-terminal kinase is necessary for protection of L929 fibrosarcoma cells from staurosporine-mediated cell death. (11327694)	Chang N.S.	2001	TGFB1, BMP6
34	ETV6 rearrangements in patients with infantile fibrosarcomas and congenital mesoblastic nephromas by fluorescence in situ hybridization. (11743047)	Adem C.... Nascimento A.G.	2001	ETV6
35	Ral promotes anchorage-independent growth of a human fibrosarcoma, HT1080. (11162603)	Yamazaki Y.... Koide H.	2001	RALA
36	Ovarian fibrosarcoma producing multiple cytokines. (11696180)	Fukuda T.... Suzuki T.	2001	KITLG, INHA
37	Stanniocalcin 1 and 2 are secreted as phosphoproteins from human fibrosarcoma cells. (10947959)	Jellinek D.A.... Reddel R.R.	2000	CSNK2A2, STC2, STC1
38	Effects of tea polyphenols on the invasion and matrix metalloproteinases activities of human fibrosarcoma HT1080 cells. (10794635)	Maeda-Yamamoto M.... Isemura M.	1999	MMP2, MMP9
39	Detection of DNA abnormalities by arbitrarily primed PCR fingerprinting: amplification of the MDM2 gene in a mediastinum fibrosarcoma. (10329377)	Kuchiki H.... Sekiya T.	1999	MDM2
40	The transcription factor EGR-1 suppresses transformation of human fibrosarcoma HT1080 cells by coordinated induction of transforming growth factor-beta1, fibronectin, and plasminogen activator inhibitor-1. (9933644)	Liu C.... Mercola D.	1999	SERPINE1, EGR1
41	Overexpression of manganese superoxide dismutase selectively modulates the activity of Jun-associated transcription factors in fibrosarcoma cells. (9393747)	Kiningham K.K.... St Clair D.K.	1997	SOD2
42	Suppression of transformed phenotypes of human fibrosarcoma cells by overexpression of recombinant fibronectin. (8813154)	Akamatsu H.... Sekiguchi K.	1996	FN1
43	Retention of unmethylated CpG island alleles in human diploid fibroblast x fibrosarcoma hybrids expressing high levels of DNA methyl transferase. (8780898)	Kuerbitz S.J.... Baylin S.B.	1996	DNMT1
44	Congenital-infantile fibrosarcoma: a clinicopathological study of five patients entered on the Prague children's tumor registry. (8897521)	Kodet R.... Eckschlager T.	1996	F13A1
45	Use of the stress-inducible grp78/BiP promoter in targeting high level gene expression in fibrosarcoma in vivo. (7712471)	Gazit G.... Lee A.S.	1995	HSPA5
46	Cyclic AMP-regulated synthesis of the tissue inhibitors of metalloproteinases suppresses the invasive potential of the human fibrosarcoma cell line HT1080. (7796421)	Tanaka K.... Sugioka Y.	1995	MMP2
47	Matrix metalloproteinase 9 (92-kDa gelatinase/type IV collagenase) from HT 1080 human fibrosarcoma cells. Purification and activation of the precursor and enzymic properties. (1400481)	Okada Y.... Hayakawa T.	1992	MMP9
48	Molecular analysis of the inhibition of interleukin-8 production by dexamethasone in a human fibrosarcoma cell line. (1592440)	Mukaida N.... Matsushima K.	1992	IL8, IL1A, CRAT
49	Modulation of vinblastine sensitivity by dipyridamole in multidrug resistant fibrosarcoma cells lacking mdr1 expression. (1680368)	Shalinsky D.R.... Howell S.B.	1991	ABCB1
50	Properties of monocyte chemotactic and activating factor (MCAF) purified from a human fibrosarcoma cell line. (2161898)	Zachariae C.O.... Matsushima K.	1990	CCL2

Genes related to fibrosarcoma according to GeneCards:

(show top 50)    (show all 296)

id	Symbol	Description	Score	GeneCards Section Context
1	ETV6	ets variant 6	11.1	Functions, Summaries, Publications
2	MAFF	v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)	11.0	Orthologs, Transcripts, Functions, Aliases & Descriptions
3	MAFK	v-maf musculoaponeurotic fibrosarcoma oncogene homolog K (avian)	11.0	Transcripts, Orthologs, Functions, Aliases & Descriptions
4	MAF	v-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian)	11.0	Functions, Orthologs, Aliases & Descriptions, Transcripts
5	MAFG	v-maf musculoaponeurotic fibrosarcoma oncogene homolog G (avian)	11.0	Transcripts, Orthologs, Functions, Aliases & Descriptions
6	MAFA	v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian)	11.0	Aliases & Descriptions, Transcripts, Orthologs
7	MAFB	v-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian)	11.0	Orthologs, Transcripts, Aliases & Descriptions
8	NFE2L3	nuclear factor (erythroid-derived 2)-like 3	11.0	Summaries
9	STIM1	stromal interaction molecule 1	11.0
10	PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	11.0	Publications
11	NTRK3	neurotrophic tyrosine kinase, receptor, type 3	11.0	Functions, Publications
12	B3GNT1	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1	11.0
13	CMAS	cytidine monophosphate N-acetylneuraminic acid synthetase	11.0
14	B3GNT6	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6 (core 3 synthase)	11.0
15	TFPI2	tissue factor pathway inhibitor 2	11.0	Publications
16	ST3GAL2	ST3 beta-galactoside alpha-2,3-sialyltransferase 2	11.0
17	STC1	stanniocalcin 1	11.0	Publications
18	TMSB4X	thymosin beta 4, X-linked	11.0	Publications
19	MMP14	matrix metallopeptidase 14 (membrane-inserted)	11.0	Publications
20	APRT	adenine phosphoribosyltransferase	11.0	Publications
21	HMMR	hyaluronan-mediated motility receptor (RHAMM)	11.0	Publications
22	SPINK1	serine peptidase inhibitor, Kazal type 1	11.0	Publications
23	AIMP1	aminoacyl tRNA synthetase complex-interacting multifunctional protein 1	11.0	Publications
24	MMP2	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	11.0	Publications
25	GLO1	glyoxalase I	11.0
26	EGR1	early growth response 1	11.0	Publications
27	VTN	vitronectin	11.0	Publications
28	GLB1	galactosidase, beta 1	11.0	Publications
29	GPI	glucose-6-phosphate isomerase	11.0	Publications
30	STAT2	signal transducer and activator of transcription 2, 113kDa	11.0
31	CAD	carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase	11.0
32	MLANA	melan-A	11.0
33	RNASEL	ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)	11.0
34	DES	desmin	11.0	Publications
35	SPARC	secreted protein, acidic, cysteine-rich (osteonectin)	11.0	Publications
36	ITGA3	integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)	11.0	Publications
37	TIMP1	TIMP metallopeptidase inhibitor 1	11.0	Publications
38	TIMP3	TIMP metallopeptidase inhibitor 3	11.0	Publications
39	CA9	carbonic anhydrase IX	11.0	Publications
40	PLAU	plasminogen activator, urokinase	11.0	Publications
41	TIMP2	TIMP metallopeptidase inhibitor 2	11.0	Publications
42	RHOD	ras homolog family member D	11.0	Publications
43	ACTC1	actin, alpha, cardiac muscle 1	11.0	Publications
44	MMP9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)	11.0	Publications
45	TYK2	tyrosine kinase 2	11.0	Publications
46	KRT8	keratin 8	11.0
47	FN1	fibronectin 1	11.0	Publications
48	CIITA	class II, major histocompatibility complex, transactivator	11.0
49	RECK	reversion-inducing-cysteine-rich protein with kazal motifs	11.0
50	LCP1	lymphocyte cytosolic protein 1 (L-plastin)	11.0

Pathways related to fibrosarcoma according to GeneDecks:

(show top 50)    (show all 368)

id	Pathway	Score	Top Affiliating Genes
1	UPA-UPAR Pathway36	12.2	VTN, SERPINE1, LAMA1, LAMB1, JUN, JAK1
2	Integrin Pathway36	11.6	RAF1, RAC1, RAC2, LAMA1, LAMB1, FYN
3	Angiogenesis3	11.5	RECK, VHL, KDR, ITGA6, ITGB1, MMP2
4	PDGF Pathway36	11.4	RAF1, RAC1, JUN, JAK1, JAK2, FOS
5	Colorectal cancer20	11.3	PIK3CG, RAC1, RAC2, FOS, MAPK8, MAP2K1
6	Cell adhesion_Cell-matrix glycoconjugates41	10.9	VCAN, LGALS3, LAMA1, LAMB1, ITGA3, ITGB1
7	Pancreatic cancer20	10.8	RALA, RAC2, CDK6
8	Cell adhesion PLAU signaling10	10.8	VTN, SERPINB2, SERPINE1, RAF1, JAK1, ITGB1
9	Fc epsilon RI signaling pathway20	10.8	PIK3CG, RAC1, RAC2, FYN, IL4, MAP2K1
10	Immune response_Oncostatin M signaling via MAPK in human cells41	10.8	RAF1, RAC1, JUN, JUNB, JUND, JAK1
11	Development_EGFR signaling pathway41	10.8	RAF1, RAC1, JUN, JAK1, MMP2, MMP9
12	Regulation of actin cytoskeleton20	10.7	MYLK3, RAF1, RAC2, ITGA2, ITGA3, ITGA4
13	Cell adhesion Cell-matrix glycoconjugates10	10.7	VCAN, LGALS3, MUC1, LAMA1, LAMB1, ITGA3
14	Ceramide Pathway36	10.7	RAF1, JUN, JUNB, JUND, FOS, MAPK8
15	Development_Prolactin receptor signaling41	10.7	RAF1, RAC1, BCL2, BCL2L1, FYN, JUN
16	Rac1 Pathway36	10.7	KITLG, BMP6, RAF1, RAC1, KDR, JUN
17	FAK1 Signaling36	10.7	RAF1, RAC1, RAC2, LAMA1, LAMB1, FYN
18	Paxillin Interactions36	10.3	KIT, KITLG, RAC1, KDR, MUSK, ITGA2
19	CREB Pathway36	10.3	KIT, KITLG, BMP6, KDR, IL2, MAP2K1
20	Development_VEGF signaling via VEGFR2 - generic cascades41	10.3	VEGFA, RAF1, RAC1, FYN, JUN, FOS
21	CDC42 Pathway36	10.2	KIT, RAF1, RALA, KDR, MUSK, JUN
22	Signal transduction PTEN pathway10	10.2	RAF1, JUN, CDKN1A, ITGB1, MAPK3, MAPK1
23	Activation of cAMP-Dependent PKA36	10.2	KITLG, RAF1, KDR, MUSK, INSR, MET
24	PPAR Pathway36	10.1	KIT, KITLG, RAF1, ITGA2, ITGA3, ITGA4
25	Activation of PKA through GPCR36	10.1	KIT, KITLG, BMP6, RAF1, KDR, MUSK
26	ERK Signaling36	10.0	KIT, KITLG, BMP6, RAF1, MUSK, LAMA1
27	p53 Signaling36	9.8	BCL2, CDKN1A, CDK4, FOS, MDM2, MAPK8
28	Chronic myeloid leukemia20	9.8	PIK3CG, RB1, RAF1, BCL2L1, CDK6, CDKN1A
29	Tuberculosis20	9.8	RAF1, BCL2, CIITA, JAK1, JAK2, CD14
30	Transcription P53 signaling pathway10	9.8	VEGFA, CDKN2A, MAPK8, MAPK10, TP53, EP300
31	T cell receptor signaling pathway20	9.7	PIK3CG, RAF1, FYN, JUN, CD4, CDK4
32	TRKA Signaling36	9.7	RAF1, RAC1, RAC2, JUN, APAF1, MAPK8
33	Endothelin-1 Signaling Pathway36	9.6	KIT, BMP6, RAF1, MUSK, INSR, IL1A
34	p70S6K Signaling36	9.5	KIT, KITLG, BMP6, RAF1, RAC1, RAC2
35	Glioblastoma Multiforme36	9.4	RB1, RAF1, RAC1, CDK6, CDKN1A, CDK4
36	DHA Signaling36	9.3	KIT, KITLG, BMP6, KDR, BCL2, BCL2L1
37	Nanog in Mammalian ESC Pluripotency36	9.3	KIT, KITLG, BMP6, RAF1, KDR, MUSK
38	Intracellular Calcium Signaling36	9.2	KIT, KITLG, BMP6, KDR, MUSK, INSR
39	Pancreatic Adenocarcinoma36	9.2	KIT, KITLG, RB1, BMP6, RAF1, RAC1
40	Molecular Mechanisms of Cancer36	9.1	PIK3CG, KITLG, RB1, BMP6, RAF1, RAC2
41	MIF Regulation of Innate Immune Cells36	8.9	BMP6, BCL2, JUN, CD14, FOS, IL15
42	Glioma20	8.9	PIK3CG, RB1, RAF1, CDK6, CDKN1A, CDKN2A
43	UVC-Induced MAPK Signaling36	8.8	RAF1, JUN, FOS, MAPK8, MAPK3, MAPK14
44	Melanoma20	8.8	PIK3CG, RB1, RAF1, CDK6, CDKN1A, CDKN2A
45	PAK Pathway36	8.8	KIT, KITLG, BMP6, RAC1, RAC2, KDR
46	JAK-STAT Pathway36	8.8	KIT, KITLG, BMP6, RAF1, KDR, BCL2
47	Prostate cancer20	8.7	PIK3CG, RB1, RAF1, BCL2, CDKN1A, MDM2
48	p53 Mediated Apoptosis36	8.6	KIT, KITLG, BMP6, KDR, BCL2, FGF2
49	TGF-Beta Pathway36	8.4	KITLG, BMP6, KDR, BCL2, JUN, CD4
50	p38 Signaling36	7.2	KIT, KITLG, BMP6, RALA, RAC1, KDR

Compounds related to fibrosarcoma according to GeneDecks:

(show top 50)    (show all 486)

id	Compound	Score	Top Affiliating Genes
1	ascorbic acid32 18	12.8	PIK3CG, SETD2, SERPINB2, RAF1, RAC1, P4HB
2	lipid32	11.8	PIK3CG, RECK, KITLG, VTN, RB1, SETD2
3	sucrose32 9 18 9	14.7	RECK, MYOD1, RAD51, CIITA, MVP, P4HB
4	phorbol32	11.5	SERPINB2, MYB, RAF1, RAC1, RAC2, JUN
5	h2o232	11.4	PIK3CG, KITLG, SERPINB2, MYB, RAD51, CLU
6	vegf32	11.3	PIK3CG, RECK, KIT, KITLG, VTN, SETD2
7	pge232	11.2	VTN, SETD2, SERPINB2, RAF1, RAC1, CIITA
8	aprotinin32 9 9	13.2	SERPINB2, MMP13, MMP2, MMP9, FN1, IL1A
9	estrogen32	11.1	SETD2, SERPINB2, SERPINE1, VHL, MYOD1, RAD51
10	nacl32	11.0	VCAN, RAD51, S100A1, ITGA2, ITGB1, MMP13
11	heparan sulfate32 18	12.0	VTN, SERPINE1, VIM, VCAN, BMP6, KDR
12	biotin32 9 18 9	14.0	KITLG, RB1, VIM, MUC1, S100A1, CDKN2A
13	phosphatidylserine32 9 9	12.9	RECK, VIM, RAC1, PARP1, BCL2, CD14
14	vanadate32	10.9	SETD2, FYN, JAK1, JAK2, INSR, MBP
15	forskolin32 42 9 9	13.8	VIM, BMP6, RAF1, RAC1, MUC1, JUN
16	aspirin32 34 18	12.7	KITLG, VTN, SERPINE1, BMP6, RAF1, LGALS3
17	wortmannin32 42	11.6	PIK3CG, KITLG, VTN, SETD2, VIM, MYLK3
18	methylcellulose32	10.6	KIT, KITLG, MYB, CD14, CD34, FGF2
19	norepinephrine32 9 18 9	13.5	KITLG, BMP6, JUNB, CD14, MMP1, MMP2
20	etoposide32 42 9 9	13.5	PIK3CG, RECK, RB1, SETD2, CLU, PARP1
21	n-formylmethionyl-leucylphenylalanine32	10.4	PIK3CG, VTN, RAC2, IL1A, MAPK3, MAPK14
22	phosphatidylcholine32	10.4	VIM, RAF1, RAC1, P4HB, ITGA2, ITGB1
23	nmda32 42	11.4	VIM, BCL2L1, P4HB, FYN, JUNB, JAK2
24	fmlp32	10.3	PIK3CG, VIM, RAC1, RAC2, LCP1, CD14
25	ly29400232	10.3	PIK3CG, VTN, VHL, VEGFA, JUN, MMP14
26	doxorubicin32 34 9 9	13.3	PIK3CG, RECK, KIT, KITLG, SETD2, VIM
27	zoledronic acid32	10.2	PARP1, CD36, MMP9, IL2, ANXA5, HRAS
28	5-aza-2deoxycytidine32	10.2	KITLG, VIM, VHL, MYOD1, BMP6, CLU
29	histamine32 18	11.1	KIT, KITLG, VIM, BMP6, RAF1, CMA1
30	melphalan32 9 9	12.0	RAD51, BCL2L1, MVP, MMP2, IL4, APRT
31	thapsigargin32 42	10.9	PIK3CG, SERPINE1, MYB, RAF1, BCL2, BCL2L1
32	thalidomide32 42 9 9	12.8	VTN, VEGFA, KDR, BCL2L1, CD36, FGF2
33	ag 147832	9.7	PIK3CG, SERPINE1, RAF1, JUN, JAK2, ITGA2
34	3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide32	9.6	PARP1, BCL2, BCL2L1, MMP2, MMP9, MET
35	gefitinib32 34 9 9	12.6	PIK3CG, KIT, VIM, VEGFA, RAD51, KDR
36	rantes32	9.3	KITLG, BMP6, RAC1, CIITA, JUN, CD14
37	dexamethasone32 42 34 9 9	13.3	KITLG, VTN, RB1, SERPINB2, SERPINE1, VIM
38	erlotinib32 34 9 9	12.2	KIT, VEGFA, KDR, MAPK1, CCND1, IGF1
39	cytarabine32 34 9 9	12.2	KIT, KITLG, RB1, VIM, CMPK1, BCL2
40	ang ii32	9.1	PIK3CG, VEGFA, JAK2, CD36, ANPEP, MAPK8
41	butyrate32	9.1	KITLG, RB1, SETD2, VIM, MYB, MYOD1
42	suramin32 9 9	11.0	RECK, VEGFA, BMP6, RAF1, KDR, FOS
43	paclitaxel32 34 9 9	12.0	PIK3CG, KIT, KITLG, RB1, SETD2, VIM
44	ciglitazone32	9.0	SERPINE1, PARP1, BCL2L1, JUN, CDKN1A, MMP2
45	quercetin32 42 9 18 9	12.9	PIK3CG, RAF1, PARP1, BCL2, BCL2L1, JUN
46	hydrocortisone32 9 9	10.6	KITLG, VIM, BMP6, KDR, MUC1, CD36
47	genistein32 9 18 9	11.3	PIK3CG, KITLG, RB1, SETD2, SERPINE1, VIM
48	cisplatin32 34 9 9	11.0	KITLG, VTN, RB1, SETD2, VEGFA, BMP6
49	carboplatin32 34 9 9	10.4	KITLG, RB1, VEGFA, PARP1, KDR, BCL2
50	triptolide32	6.8	VEGFA, PARP1, BCL2, JUN, CD14, MMP3

Cellular components related to fibrosarcoma according to GeneDecks:

(show all 13)

id	Name	GO ID	Score	Top Affiliating Genes
1	cell surface	GO:009986	11.0	PLAUR, PLAU, CTSG, TNF, HMMR, ABCB1
2	integral to plasma membrane	GO:005887	10.9	ABCC1, PDPN, PDGFRB, PDGFRA, PLAUR, NTRK3
3	plasma membrane	GO:005886	10.6	CTGF, CTSG, NRAS, PLAU, PLAUR, PLG
4	proteinaceous extracellular matrix	GO:005578	10.4	FBLN1, TNC, SPARC, CTGF, ELN, TGFB1
5	extracellular matrix	GO:031012	10.4	F3, TPSAB1, TNC, CTSD, CTSG, TIMP3
6	external side of plasma membrane	GO:009897	10.1	IL4, ANXA5, ANPEP, CCR1, IFNG, TNF
7	platelet alpha granule lumen	GO:031093	10.0	PLG, EGF, TIMP1, THBS1, TGFB1, SPARC
8	nucleus	GO:005634	9.8	CTSL1, SPARC, SP3, SP1, SSX2B, PPARA
9	nucleoplasm	GO:005654	9.5	EP300, TXN, AKT1, CASP3, CASP7, CCND1
10	extracellular region	GO:005576	9.5	TGFB1, THBS1, TIMP2, TIMP1, ELANE, EGF
11	cytoplasm	GO:005737	8.7	NQO1, NOS2, RPS3, RPSA, PDGFRA, PDGFRB
12	extracellular space	GO:005615	8.1	SPARC, IL7, IL4, IL2, IL1A, IL17A
13	cytosol	GO:005829	INF	RPSA, CAV1, CAV2, CASP1, CASP3, CASP7

Biological processes related to fibrosarcoma according to GeneDecks:

(show top 50)    (show all 63)

id	Name	GO ID	Score	Top Affiliating Genes
1	extracellular matrix organization	GO:030198	11.5	CMA1, GFAP, LGALS3, ELANE, PLG, RECK
2	extracellular matrix disassembly	GO:022617	11.5	MMP14, TIMP1, TPSAB1, MMP9, CMA1, MMP1
3	proteolysis	GO:006508	11.3	CTSD, TMPRSS15, TNFAIP3, CASP1, CASP3, CASP7
4	peptidyl-tyrosine phosphorylation	GO:018108	11.1	CSF1R, KIT, KDR, FYN, JAK1, JAK2
5	leukocyte migration	GO:050900	11.1	MMP1, CD34, ROCK1, AIMP1, FYN, JAM3
6	inflammatory response	GO:006954	11.0	ADAM8, CCR1, AKT1, AIMP1, TNF, IL1A
7	activation of MAPKK activity	GO:000186	10.8	RAF1, JAK2, NRAS
8	response to organic cyclic compound	GO:014070	10.7	JUNB, CDKN1A, MET, IL1A, IL4, CCND1
9	response to wounding	GO:009611	10.7	GFAP, FN1, CTGF, MET, CTSB, TGFB1
10	innate immune response	GO:045087	10.6	MAPK14, TXN, CASP1, IFNB1, MAPK3, MAP2K1
11	negative regulation of gene expression	GO:010629	10.6	CDKN1A, CD34, MKKS, INSR, CCR1, GJA1
12	virus-host interaction	GO:019048	10.6	SP1, MAPK1, ANPEP, MDM2, FBLN1, MMP1
13	protein autophosphorylation	GO:046777	10.6	KDR, KIT, CSF1R, EGFR, MUSK, FYN
14	activation of MAPK activity	GO:000187	10.5	ALK, PLA2G1B, MAPK10, MAPK1, MAP2K1, GHR
15	positive regulation of cell migration	GO:030335	10.4	PDGFRA, F3, TGFB1, THBS1, ABCC1, PDPN
16	blood coagulation	GO:007596	10.4	TFPI2, STIM1, PSAP, PRKCD, SOD1, TGFB1
17	negative regulation of cell proliferation	GO:008285	10.3	IGF1, IFNB1, HRAS, GJA1, TP53, TNF
18	platelet activation	GO:030168	10.3	VEGFA, PIK3CG, PTK2, SPARC, PLG, RHOA
19	angiogenesis	GO:001525	10.2	EPHA2, KDR, JUN, JAM3, MMP2, FN1
20	platelet degranulation	GO:002576	10.2	IGF1, F13A1, HSPA5, TMSB4X, SPARC, PLG
21	axon guidance	GO:007411	10.2	HSP90AA1, MAP2K1, RAC1, RAF1, CREB1, LAMA1
22	negative regulation of neuron apoptotic process	GO:043524	10.2	ROCK1, SOD2, ADAM8, SOD1, HIF1A, GPI
23	cytokine-mediated signaling pathway	GO:019221	10.2	IRF1, STAT3, STAT1, TYK2, RNASEL, HLA-B
24	nerve growth factor receptor signaling pathway	GO:048011	10.2	NRAS, TIAM1, CREB1, RHOA, RAF1, RALA
25	positive regulation of fibroblast proliferation	GO:048146	10.1	JUN, CDK6, CDK4, IGF1, DDR2, PLA2G1B
26	positive regulation of gene expression	GO:010628	10.1	MAPK8, E2F1, DNMT1, TGFB1, PLAUR, PLAG1
27	cellular component movement	GO:006928	10.1	ENPP2, IGF1, IFNG, AMFR, MAP2K1, MAPK14
28	positive regulation of protein phosphorylation	GO:001934	10.0	CCND1, MAPK3, INSR, MUSK, VEGFA, IGF2
29	positive regulation of protein kinase B signaling cascade	GO:051897	10.0	TGFB1, PTK2, ADAM8, INSR, IGF2, IGF1
30	MAPK cascade	GO:000165	9.8	RAF1, MAPK3, TGFB1, EGFR, NRAS, TNF
31	response to ethanol	GO:045471	9.7	IL4, CTSB, SPARC, CCND1, CCL2, INSR
32	positive regulation of transcription, DNA-dependent	GO:045893	9.6	CREB1, TGFB1, CDKN2A, JUN, HIF1A, CIITA
33	cellular response to hypoxia	GO:071456	9.6	VHL, TP53, VEGFA, EP300, ADAM8, STC2
34	positive regulation of DNA replication	GO:045740	9.6	PLA2G1B, EGFR, PDGFRA, HRAS, IGF1, MET
35	induction of apoptosis by intracellular signals	GO:008629	9.6	CASP7, TP53, CLU, HRAS, CASP3, MAPK8
36	cell proliferation	GO:008283	9.5	MAP2K1, BCL2L1, EGFR, PDPN, TP53, TXN
37	Ras protein signal transduction	GO:007265	9.5	CDKN2A, RAF1, RALA, CDKN1A, FGF2, MAPK3
38	negative regulation of apoptotic process	GO:043066	9.4	BCL2, TIMP1, THBS1, SOD2, NES, EGFR
39	apoptotic process	GO:006915	9.4	EP300, GABARAP, EPHA2, E2F1, ROCK1, CSNK2A2
40	cellular response to lipopolysaccharide	GO:071222	9.3	NOS2, IL8, SERPINE1, TSPO, CD36, TNFRSF1B
41	anti-apoptosis	GO:006916	9.3	MUC1, THBS1, AKT1, TNF, TNFAIP3, NR3C1
42	positive regulation of cell proliferation	GO:008284	9.3	MDM2, IGF2, IGF1, HRAS, PTK2, CTGF
43	signal transduction	GO:007165	9.2	CREB1, PLA2G1B, PLAU, PLAUR, PDGFRB, PDPN
44	response to drug	GO:042493	9.2	BCL2, MVP, FYN, JUN, JUNB, ACTC1
45	positive regulation of MAP kinase activity	GO:043406	9.2	KITLG, VEGFA, TNF, PIK3CG, EGFR, TGFB1
46	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	9.1	OSM, TP53, ITGB1, GHR, IGF1, IGF2
47	release of cytochrome c from mitochondria	GO:001836	9.0	SOD2, BCL2, BCL2L1, JUN, CASP7, CASP3
48	positive regulation of transcription from RNA polymerase II promoter	GO:045944	9.0	RB1, SERPINE1, VEGFA, MYB, MYOD1, BMP6
49	cell cycle arrest	GO:007050	8.9	IL8, TP53, HRAS, DDIT3, IFNG, MAP2K1
50	cell surface receptor signaling pathway	GO:007166	8.8	MAPK14, INHA, CD4, CD14, CD36, LAMA1

Molecular functions related to fibrosarcoma according to GeneDecks:

(show all 15)

id	Name	GO ID	Score	Top Affiliating Genes
1	sequence-specific DNA binding	GO:043565	11.0	SP1, PPARA, NR3C1, CREB3L1, CREB3L2, NFE2L3
2	integrin binding	GO:005178	10.7	CTGF, GFAP, TIMP2, THBS1, THY1, IGF1
3	transmembrane receptor protein tyrosine kinase activity	GO:004714	10.4	EPHA2, EGFR, PDGFRA, NTRK3, DDR2, ALK
4	double-stranded DNA binding	GO:003690	10.3	NR3C1, CREB1, EGFR, EGR1, STAT1, SP3
5	protein tyrosine kinase activity	GO:004713	10.2	MET, MAP2K1, PDGFRB, EGFR, TYK2, INSR
6	ATP binding	GO:005524	10.1	PTK2, DDR2, NTRK3, RNASEL, PDGFRA, TEC
7	transcription factor binding	GO:008134	9.8	TP53, DDIT3, SP1, HIF1A, DNMT1, STAT3
8	protease binding	GO:002020	9.6	CST3, ELANE, TNFAIP3, TNF, TP53, F3
9	protein kinase binding	GO:019901	9.5	HSPB1, GHR, TP53, PTK2, RPS3, HIF1A
10	protein binding	GO:005515	9.5	PDGFRA, CTSB, SPARC, SP3, SPINK1, SP1
11	cytokine activity	GO:005125	9.3	GPI, IFNB1, IFNG, AIMP1, TNF, TNFSF10
12	growth factor activity	GO:008083	8.8	IGF2, IGF1, CTGF, EGF, TGFB1, OSM
13	enzyme binding	GO:019899	8.8	PLAUR, EGFR, HIF1A, TGFB1, STAT1, PRKCD
14	protein heterodimerization activity	GO:046982	8.3	MAFA, MAF, TP53, NR3C1, EGFR, HIF1A
15	protein homodimerization activity	GO:042803	INF	TYR, ABCG2, PDGFRA, NOS2, NR3C1, TKT