MCID: FBR017
MIFTS: 66

Fibrosarcoma malady

Bone diseases, Cancer diseases categories

Summaries for Fibrosarcoma

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63Wikipedia, 46OMIM, 32MalaCards
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Wikipedia:63 Fibrosarcoma (fibroblastic sarcoma) is a malignant mesenchymal tumour derived from fibrous connective... more...

MalaCards: Fibrosarcoma, also known as fibrosarcoma of the soft tissue, is related to congenital fibrosarcoma and osteosarcoma. An important gene associated with Fibrosarcoma is ETV6 (ets variant 6), and among its related pathways are Tacrolimus/Cyclosporine Pathway, Pharmacodynamics and Matrix Metalloproteinases. The drug dacarbazine and the compounds vegf and matrigel have been mentioned in the context of this disorder. Affiliated tissues include bone, breast and colon, and related mouse phenotypes are growth/size and mortality/aging.

Description from OMIM:46 117600

Aliases & Classifications for Fibrosarcoma

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 48Orphanet, 46OMIM, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH, 35MESH via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Bone diseases


Characteristics (Orphanet epidemiological data):

48
fibrosarcoma:
Age of onset: Variable


Aliases & Descriptions:

fibrosarcoma 8 42 10 44 48 46 60
fibrosarcoma of the soft tissue 8
fibrosarcoma of soft tissue 8
neoplasms, fibrous tissue 60
fibrous tissue neoplasm 8
fibrocytic tumor 8


External Ids:

Disease Ontology8 DOID:3355
NCIt39 C3043
MeSH34 D005354
OMIM46 117600
SNOMED-CT56 443250000, 53654007
MESH via Orphanet35 D005354
SNOMED-CT via Orphanet57 53654007
UMLS via Orphanet61 C0016057

Related Diseases for Fibrosarcoma

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17GeneCards, 18GeneDecks
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Diseases in the Fibrosarcoma family:

Adult Fibrosarcoma Congenital Fibrosarcoma

Diseases related to Fibrosarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 142)
idRelated DiseaseScoreTop Affiliating Genes
1congenital fibrosarcoma31.2ETV6, GOLGA6A, GOLGA6B
2osteosarcoma30.4PDGFRA, EGR1, ING1, MMP14, MMP2, MMP9
3congenital mesoblastic nephroma30.2ETV6, NTRK3
4chondrosarcoma30.2MMP14, PDGFRA
5leukemia30.1PDGFRA, STC1, EGR1, NTRK3, ETV6
6breast cancer30.0TFPI2, STC1, EGR1, NTRK3, ETV6, MMP14
7adenocarcinoma30.0TFPI2, EGR1, NTRK3, ING1, MMP14, MMP2
8hepatocellular carcinoma29.7PDGFRA, TFPI2, STC1, EGR1, ING1, MMP14
9squamous cell carcinoma29.7PDGFRA, TFPI2, EGR1, ING1, MMP14, MMP2
10astrocytoma29.7PDGFRA, EGR1, MMP14, MMP2, MMP9
11colon cancer29.7EGR1, NTRK3, MMP14, MMP2, MMP9
12myeloid leukemia29.7EGR1, NTRK3, ETV6
13stomach cancer29.7MMP9, MMP2, MMP14, ING1, EGR1
14fibrosarcoma of bone10.6
15breast fibrosarcoma10.4
16heart fibrosarcoma10.4
17adult fibrosarcoma10.3
18liver fibrosarcoma10.3
19sarcoma10.3
20fibrous histiocytoma10.2
21dermatofibrosarcoma10.2
22kidney fibrosarcoma10.2
23histiocytoma10.2
24pediatric fibrosarcoma10.2
25small bowel fibrosarcoma10.2
26conventional fibrosarcoma10.1
27central nervous system fibrosarcoma10.1
28bone osteosarcoma10.1
29hemangioma10.1
30liposarcoma10.1
31rhabdomyosarcoma10.1
32thyroiditis10.1
33malignant fibrous histiocytoma of bone10.1
34cerebritis10.1
35hypoglycemia10.1
36basal cell carcinoma10.1
37fasciitis10.1
38melanoma10.0PDGFRA, TFPI2, EGR1, NTRK3, ING1, MMP14
39brain cancer10.0PDGFRA, TFPI2, EGR1, NTRK3, ING1, MMP14
40non-small cell lung carcinoma10.0PDGFRA, TFPI2, EGR1, MMP14, MMP2, MMP9
41glioblastoma multiforme10.0PDGFRA, TFPI2, EGR1, MMP14, MMP2, MMP9
42lung cancer10.0PDGFRA, TFPI2, EGR1, ING1, MMP2, MMP9
43malignant glioma10.0PDGFRA, EGR1, MMP14, MMP2, MMP9
44squamous cell carcinoma of the head and neck10.0MMP9, MMP2, MMP14, EGR1
45lung adenocarcinoma10.0MMP9, MMP2, MMP14, NTRK3
46aneurysm disease10.0MMP9, MMP2, MMP14
47bladder carcinoma10.0MMP9, MMP2, MMP14, EGR1
48myelodysplastic syndromes10.0PDGFRA, EGR1, ETV6
49myeloproliferative disorder10.0ETV6, NTRK3, PDGFRA
50prostate cancer10.0MMP9, MMP2, MMP14, EGR1

Graphical network of the top 20 diseases related to Fibrosarcoma:



Diseases related to fibrosarcoma

Clinical Features for Fibrosarcoma

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Sources:
46OMIM
See all sources

Clinical features from OMIM:

117600

Clinical synopsis from OMIM:

117600

Drugs & Therapeutics for Fibrosarcoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Fibrosarcoma

Drug clinical trials:

Search ClinicalTrials for Fibrosarcoma

Search NIH Clinical Center for Fibrosarcoma

Search CenterWatch for Fibrosarcoma

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Fibrosarcoma

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Anatomical Context for Fibrosarcoma

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32MalaCards
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MalaCards organs/tissues related to Fibrosarcoma:

32
Bone, Breast, Colon, Lung, Heart, T cells, Ovary, Liver, Thyroid, Kidney, Endothelial, Pancreas, Tongue, Monocytes, Myeloid, Skin, Brain, Pituitary, Thymus, Nk cells, Lymph node

Animal Models for Fibrosarcoma or affiliated genes

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36MGI
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Publications for Fibrosarcoma

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Sources:
50PubMed
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Articles related to Fibrosarcoma:

(show top 50)    (show all 767)
idTitleAuthorsYear
1
Dietary gallic acid and anthocyanin cytotoxicity on human fibrosarcoma HT1080 cells. A study on the mode of action. (24413695)
2014
2
Ameloblastic fibrosarcoma of the upper jaw: Report of a rare case with long-term follow-up. (23878574)
2013
3
Inhibitory effects of p-dodecylaminophenol on the invasiveness of human fibrosarcoma cell line HT1080. (23953690)
2013
4
Targeting androgen receptor/Src complex impairs the aggressive phenotype of human fibrosarcoma cells. (24130806)
2013
5
1,2,3,4-Diepoxybutane-induced DNA-protein cross-linking in human fibrosarcoma (HT1080) cells. (23506368)
2013
6
Negatively-regulated necroptosis by autophagy required caspase-6 activation in TNFI+-treated murine fibrosarcoma L929 cells. (23941769)
2013
7
Quercetin suppresses intracellular ROS formation, MMP activation, and cell motility in human fibrosarcoma cells. (23902346)
2013
8
Infantile fibrosarcoma of the maxillary sinus: significant response. (22430333)
2012
9
Dermatofibrosarcoma protuberans-derived fibrosarcoma: clinical history, biological profile and sensitivity to imatinib. (21128251)
2011
10
Sclerosing epithelioid fibrosarcoma of the oral cavity. (21691827)
2011
11
Low-grade fibromyxoid sarcoma: a clinicopathologic study of 18 cases, including histopathologic relationship with sclerosing epithelioid fibrosarcoma in a subset of cases. (21550274)
2011
12
Monoamine carboxylate transporters are involved in BI-1-associated cancer metastasis in HT1080 colon fibrosarcoma cells. (21537843)
2011
13
Long-term survival with heart transplantation for fibrosarcoma of the heart. (20667366)
2010
14
Infantile fibrosarcoma of the ileum presenting with congenital bowel obstruction. (20152376)
2010
15
Secondary fibrosarcoma of the brain stem treated with cyclophosphamide and Imatinib. (20043189)
2010
16
Rapid growth of primary cerebral fibrosarcoma with conversion to glioblastoma at second recurrence. (19082530)
2009
17
Ameloblastic fibrosarcoma involving the anterior and middle skull base with intradural extension. (19884826)
2009
18
Induction of apoptosis by Polygonatum odoratum lectin and its molecular mechanisms in murine fibrosarcoma L929 cells. (19414060)
2009
19
Nano-scaled particles of titanium dioxide convert benign mouse fibrosarcoma cells into aggressive tumor cells. (19815711)
2009
20
bFGF induces changes in hyaluronan synthase and hyaluronidase isoform expression and modulates the migration capacity of fibrosarcoma cells. (19577615)
2009
21
Opposing effects of fibrosarcoma cell-derived IL-1 alpha and IL-1 beta on immune response induction. (18412246)
2008
22
Dimerization of endogenous MT1-MMP is a regulatory step in the activation of the 72-kDa gelatinase MMP-2 on fibroblasts and fibrosarcoma cells. (18627313)
2008
23
Prenatal diagnosis of infantile fibrosarcoma with diffuse metastases. (18567060)
2008
24
Mitogen-activated protein kinase kinase signaling promotes growth and vascularization of fibrosarcoma. (18319331)
2008
25
Feline vaccine-associated fibrosarcoma induced by aluminium compound in two cats: short communication. (18401961)
2008
26
Sclerosing epithelioid fibrosarcoma of the pituitary. (18097772)
2007
27
Beta-sitosterol-induced-apoptosis is mediated by the activation of ERK and the downregulation of Akt in MCA-102 murine fibrosarcoma cells. (17570321)
2007
28
Hypoxia enhances metastatic efficiency in HT1080 fibrosarcoma cells by increasing cell survival in lungs, not cell adhesion and invasion. (17699784)
2007
29
AKAP12 induces apoptotic cell death in human fibrosarcoma cells by regulating CDKI-cyclin D1 and caspase-3 activity. (17442483)
2007
30
Inhibitory effects of caffeic acid phenethyl ester on cancer cell metastasis mediated by the down-regulation of matrix metalloproteinase expression in human HT1080 fibrosarcoma cells. (16214327)
2006
31
The apparent positive cooperativity of in vivo [3H]PK-11195 binding in mouse fibrosarcoma. (16934698)
2006
32
Unexpected effect of matrix metalloproteinase down-regulation on vascular intravasation and metastasis of human fibrosarcoma cells selected in vivo for high rates of dissemination. (16322244)
2005
33
Plakoglobin is a new target gene of histone deacetylase in human fibrosarcoma HT1080 cells. (14661058)
2004
34
Sp1 regulates expression of MET, and ribozyme-induced down-regulation of MET in fibrosarcoma-derived human cells reduces or eliminates their tumorigenicity. (15067326)
2004
35
Arfaptin 1 inhibits ADP-ribosylation factor-dependent matrix metalloproteinase-9 secretion induced by phorbol ester in HT 1080 fibrosarcoma cells. (12606037)
2003
36
Cellular mesoblastic nephroma: morphologic, cytogenetic and molecular links with congenital fibrosarcoma. (12650516)
2003
37
A novel matrix metalloproteinase inhibitor, FYK-1388 suppresses tumor growth, metastasis and angiogenesis by human fibrosarcoma cell line. (12527923)
2003
38
Infantile fibrosarcoma associated with urticaria pigmentosa. (12186369)
2002
39
Molecular detection of the ETV6-NTRK3 gene fusion differentiates congenital fibrosarcoma from other childhood spindle cell tumors. (10895816)
2000
40
Regulation of matrix metalloproteinase-2 (gelatinase A, MMP-2), membrane-type matrix metalloproteinase-1 (MT1-MMP) and tissue inhibitor of metalloproteinases-2 (TIMP-2) expression by elastin-derived peptides in human HT-1080 fibrosarcoma cell line. (9872597)
1998
41
Induction of tissue transglutaminase by dexamethasone: its correlation to receptor number and transglutaminase-mediated cell death in a series of malignant hamster fibrosarcomas. (9512467)
1998
42
A novel ETV6-NTRK3 gene fusion in congenital fibrosarcoma. (9462753)
1998
43
Gossypol inhibition of mitosis, cyclin D1 and Rb protein in human mammary cancer cells and cyclin-D1 transfected human fibrosarcoma cells. (9218727)
1997
44
Effect of cyclin D1 overexpression on drug sensitivity in a human fibrosarcoma cell line. (8797766)
1996
45
Congenital fibrosarcoma. Report of three cases. (8772821)
1995
46
WEHI-13VAR: a stable and sensitive variant of WEHI 164 clone 13 fibrosarcoma for tumor necrosis factor bioassay. (7590904)
1995
47
Okadaic acid-elicited transcriptional activation of collagenase gene expression in HT-1080 fibrosarcoma cells is mediated by JunB. (7848922)
1994
48
Fibrosarcoma of bone. A study of 114 cases. (5249422)
1969
49
A bone tumour registry--chondrosarcoma and fibrosarcoma of bone. (13697723)
1961
50
Central (medullary) fibrosarcoma of bone. (13491615)
1958

Genetic Variations for Fibrosarcoma

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Expression for genes affiliated with Fibrosarcoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Fibrosarcoma

Search GEO for disease gene expression data for Fibrosarcoma.

Pathways for genes affiliated with Fibrosarcoma

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49PharmGKB, 37NCBI BioSystems Database, 51QIAGEN, 4Cell Signaling Technology, 12EMD Millipore, 53Reactome
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Pathways related to Fibrosarcoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
111.0MAFB, MAFA, MAFG, MAFK, MAF, MAFF
2
Hide members
10.8MMP9, MMP2, MMP14, TFPI2
310.8PDGFRA, MMP2, MMP9
4
Cell adhesion ECM remodeling
Hide members
10.8MMP9, MMP2, MMP14
510.8MMP9, MMP2, MMP14
6
Hide members
10.7MMP14, MMP2

Compounds for genes affiliated with Fibrosarcoma

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44Novoseek, 59Tocris Bioscience, 24HMDB, 11DrugBank, 2BitterDB
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Compounds related to Fibrosarcoma according to GeneCards/GeneDecks:

(show all 44)
idCompoundScoreTop Affiliating Genes
1vegf4411.6PDGFRA, STC1, EGR1, NTRK3, ETV6, MMP14
2matrigel4411.5TFPI2, EGR1, NTRK3, MMP14, MMP2, MMP9
3leucine4411.4EGR1, MAFG, MAFK, MAF, MAFF, MMP14
4phosphatidylinositol4411.4PDGFRA, EGR1, NTRK3, MMP14, MMP2, MMP9
5tgf beta14411.4PDGFRA, EGR1, MMP14, MMP2, MMP9
6ag 14784411.3MMP9, MMP2, MMP14, EGR1
7aspartate4411.3PDGFRA, TFPI2, NTRK3, MMP2, MMP9
8sp 60012544 5912.2MMP9, MMP2, MMP14, EGR1
9cytochalasin d44 5912.2EGR1, MMP14, MMP2, MMP9
10flavanol4411.2MMP9, MMP2, MMP14
11curcumin4411.2EGR1, MMP14, MMP2, MMP9
12prinomastat4411.2MMP14, MMP2, MMP9
13retinoic acid44 2412.2PDGFRA, EGR1, NTRK3, ETV6, MMP2, MMP9
14ilomastat4411.2MMP9, MMP2, MMP14
15uk 3833675911.2MMP14, MMP2, MMP9
16gi 254023x5911.2MMP14, MMP2, MMP9
17gm 60015911.2MMP14, MMP2, MMP9
18phorbol-12-myristate4411.2EGR1, MMP14, MMP9
19hydroxamate4411.2MMP14, MMP2, MMP9
20marimastat44 59 1113.1MMP9, MMP2, MMP14
21tbhq4411.1MAF, MAFK, MAFG
22ribonucleic acid4411.1EGR1, MMP14, MMP2, MMP9
231,10-phenanthroline44 212.1MMP9, MMP2, MMP14
24batimastat44 59 1113.1MMP9, MMP2, MMP14
2512-o-tetradecanoylphorbol 13-acetate4411.1EGR1, MMP14, MMP2, MMP9
26cgs-27023a4411.0MMP2, MMP9
27methyl selenol4411.0MMP2, MMP9
28col 34411.0MMP2, MMP9
29pdtc4411.0MMP9, MMP2, MAFG
30trapidil4411.0MMP9, MMP2
31lercanidipine44 1112.0MMP9, MMP2
32tranilast4411.0MMP9, MMP2
33estrogen4411.0ING1
34tetracycline44 1111.9MMP14, MMP2, MMP9
35gelfoam4410.9MMP9, MMP2
36pd 98,0594410.9EGR1, MMP14, MMP2, MMP9
37cilomilast4410.9MMP9, MMP2
38latanoprost44 1111.9MMP9, MMP2
39cycloheximide4410.9NTRK3
40ly2940024410.8MMP9, MMP2, MMP14, EGR1
41grgdsp4410.8MMP2, MMP14
42p0024410.8MMP9, MMP14, TFPI2
43wortmannin4410.7EGR1, MMP14, MMP2, MMP9
44phorbol4410.5MMP9, MMP2, EGR1

GO Terms for genes affiliated with Fibrosarcoma

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16Gene Ontology
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Biological processes related to Fibrosarcoma according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1embryo implantationGO:00756610.9MMP9, MMP2, STC1
2collagen catabolic processGO:03057410.8MMP14, MMP2, MMP9
3regulation of epidermal cell differentiationGO:04560410.8MAFF, MAFG
4positive regulation of cell migrationGO:03033510.8MMP14, NTRK3, PDGFRA
5extracellular matrix disassemblyGO:02261710.8MMP9, MMP2, MMP14
6extracellular matrix organizationGO:03019810.7PDGFRA, MMP14, MMP2, MMP9
7transcription from RNA polymerase II promoterGO:00636610.5MAFF, MAF, NFE2L3, EGR1

Molecular functions related to Fibrosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1sequence-specific DNA bindingGO:04356511.2ETV6, EGR1, NFE2L3, MAFA, MAFG, MAFK
2sequence-specific DNA binding transcription factor activityGO:00370011.1EGR1, NFE2L3, MAFA, MAFG, MAFK, MAF
3metalloendopeptidase activityGO:00422210.8MMP9, MMP2, MMP14

Products for genes affiliated with Fibrosarcoma

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Sources for Fibrosarcoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet