MCID: FBR002
MIFTS: 36

Fibrosarcoma of Bone

Categories: Bone diseases, Cancer diseases

Aliases & Classifications for Fibrosarcoma of Bone

MalaCards integrated aliases for Fibrosarcoma of Bone:

Name: Fibrosarcoma of Bone 12 14
Fibrosarcoma of the Bone 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3354

Summaries for Fibrosarcoma of Bone

MalaCards based summary : Fibrosarcoma of Bone, also known as fibrosarcoma of the bone, is related to histiocytoma and malignant fibrous histiocytoma of bone. An important gene associated with Fibrosarcoma of Bone is PDGFRA (Platelet Derived Growth Factor Receptor Alpha), and among its related pathways/superpathways are GPCR Pathway and Phospholipase-C Pathway. Affiliated tissues include bone, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Fibrosarcoma of Bone

Diseases related to Fibrosarcoma of Bone via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 108)
# Related Disease Score Top Affiliating Genes
1 histiocytoma 29.9 CDK4 KIT MDM2 SERPINA3
2 malignant fibrous histiocytoma of bone 28.6 CALD1 CDK4 MDM2 MYC PTER
3 primary hypereosinophilic syndrome 10.6 PDGFRA PDGFRB
4 reticular perineurioma 10.6 KIT PDGFRA
5 myeloid and lymphoid neoplasms with eosinophilia and abnormalities of pdgfra, pdgfrb, and fgfr1 10.5 PDGFRA PDGFRB
6 adenosquamous gallbladder carcinoma 10.5 PDGFRA SERPINA3
7 sm-ahnmd 10.5 KIT PDGFRA
8 pulmonary vein stenosis 10.5 KDR KIT PDGFRA
9 gastric leiomyosarcoma 10.5 KIT PDGFRA
10 cervical adenosquamous carcinoma 10.5 CDKN2A KDR PDGFRA
11 desmoid tumor 10.5 KIT PDGFRA PDGFRB
12 hypereosinophilic syndrome, idiopathic 10.5 KIT PDGFRA PDGFRB
13 hepatic angiomyolipoma 10.4 KIT MYC
14 chronic eosinophilic leukemia 10.4 KIT PDGFRA PDGFRB
15 8p11 myeloproliferative syndrome 10.4 KDR KIT PDGFRB
16 neurofibroma 10.4 CDKN2A KIT PDGFRA
17 systemic mastocytosis 10.4 KIT PDGFRA PDGFRB
18 vascular cancer 10.4 KDR KIT PDGFRB
19 mast cell disease 10.4 KIT PDGFRA PDGFRB
20 leukocyte disease 10.4 KIT PDGFRA PDGFRB
21 fibrosarcoma 10.4
22 adenoid basal cell carcinoma 10.4 CDKN2A KIT
23 dermatofibrosarcoma protuberans 10.4 PDGFRA PDGFRB SERPINA3
24 acinar cell cystadenocarcinoma 10.4 SERPINA1 SERPINA3
25 bone marrow cancer 10.4 KIT PDGFRA PDGFRB
26 ring chromosome 7 10.4 CDK4 MDM2
27 angiosarcoma 10.4 KDR KIT MYC
28 hypereosinophilic syndrome 10.4 KIT PDGFRA PDGFRB
29 deep leiomyoma 10.3 CALD1 KIT
30 uterine sarcoma 10.3 KIT MDM2 PDGFRB
31 ewing's family of tumors 10.3 CDK4 CDKN2A KIT
32 carney triad 10.3 KIT PDGFRA
33 cutaneous solitary mastocytoma 10.3 KIT SERPINA1 SERPINA3
34 spindle cell lipoma 10.3 CDK4 MDM2
35 sarcomatoid renal cell carcinoma 10.3 KIT PDGFRA
36 melanoma, cutaneous malignant 1 10.3 CDK4 CDKN2A KIT
37 extraosseous osteosarcoma 10.3 CDK4 MDM2
38 gastrointestinal stromal tumor 10.3 CDKN2A KIT PDGFRA PDGFRB
39 ovarian melanoma 10.3 CALD1 KIT
40 infiltrating angiolipoma 10.3 CDK4 CDKN2A MDM2
41 gastrointestinal system cancer 10.2 CDKN2A KIT MYC PDGFRA
42 ischemic fasciitis 10.2 CDK4 CDKN2A MDM2
43 periosteal chondrosarcoma 10.2 CDK4 CDKN2A MDM2
44 well-differentiated liposarcoma 10.2 CDK4 CDKN2A MDM2
45 pilocytic astrocytoma 10.2 CDK4 CDKN2A KDR
46 dedifferentiated liposarcoma 10.2 CDK4 CDKN2A MDM2
47 undifferentiated embryonal sarcoma of the liver 10.2 CDK4 MDM2 SERPINA3
48 nodular tenosynovitis 10.2 PTER SERPINA3
49 bone osteosarcoma 10.2 CDK4 MDM2
50 leukemia, chronic myeloid 10.2 KIT MYC PDGFRA PDGFRB

Graphical network of the top 20 diseases related to Fibrosarcoma of Bone:



Diseases related to Fibrosarcoma of Bone

Symptoms & Phenotypes for Fibrosarcoma of Bone

GenomeRNAi Phenotypes related to Fibrosarcoma of Bone according to GeneCards Suite gene sharing:

25 (show all 11)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00173-A 9.88 PDGFRA
2 Decreased viability GR00221-A-1 9.88 CDKN2A PDGFRB KDR KIT MYC PDGFRA
3 Decreased viability GR00221-A-2 9.88 KDR
4 Decreased viability GR00221-A-3 9.88 CDKN2A PDGFRB KDR MYC PDGFRA
5 Decreased viability GR00221-A-4 9.88 PDGFRB KDR PDGFRA CDKN2A
6 Decreased viability GR00301-A 9.88 KIT
7 Decreased viability GR00342-S-1 9.88 PDGFRB
8 Decreased substrate adherent cell growth GR00193-A-1 9.5 KIT
9 Decreased substrate adherent cell growth GR00193-A-2 9.5 KIT CDK4
10 Decreased substrate adherent cell growth GR00193-A-3 9.5 CDK4
11 Decreased substrate adherent cell growth GR00193-A-4 9.5 KDR KIT CDK4

MGI Mouse Phenotypes related to Fibrosarcoma of Bone:

43 (show all 16)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.28 MDM2 NFATC2 KIT MYC PDGFRB STARD13
2 behavior/neurological MP:0005386 10.26 MYC NFATC2 MDM2 KIT PDGFRB PDGFRA
3 growth/size/body region MP:0005378 10.23 MDM2 NFATC2 KIT MYC PDGFRB STARD13
4 cardiovascular system MP:0005385 10.2 MDM2 KIT MYC PDGFRB STARD13 PDGFRA
5 endocrine/exocrine gland MP:0005379 10.18 MDM2 NFATC2 PDGFRA MYC PDGFRB STARD13
6 hematopoietic system MP:0005397 10.17 MDM2 NFATC2 KIT MYC PDGFRB STARD13
7 embryo MP:0005380 10.15 MDM2 NFATC2 MYC PDGFRB PDGFRA KDR
8 immune system MP:0005387 10.14 MDM2 NFATC2 KIT MYC PDGFRB STARD13
9 craniofacial MP:0005382 10.13 MDM2 NFATC2 PDGFRA MYC PDGFRB KDR
10 digestive/alimentary MP:0005381 10.11 MDM2 KIT MYC PDGFRB PDGFRA CDKN2A
11 integument MP:0010771 9.97 MDM2 KIT MYC PDGFRB PDGFRA CDK4
12 muscle MP:0005369 9.91 NFATC2 PDGFRA MYC MDM2 PDGFRB KDR
13 limbs/digits/tail MP:0005371 9.8 MYC MDM2 KIT PDGFRB PDGFRA CREB3L2
14 neoplasm MP:0002006 9.76 PDGFRA MYC MDM2 STARD13 CDKN2A KIT
15 pigmentation MP:0001186 9.43 MDM2 MYC PDGFRA CDKN2A KIT CDK4
16 skeleton MP:0005390 9.28 MDM2 NFATC2 KIT MYC PDGFRB PDGFRA

Drugs & Therapeutics for Fibrosarcoma of Bone

Search Clinical Trials , NIH Clinical Center for Fibrosarcoma of Bone

Genetic Tests for Fibrosarcoma of Bone

Anatomical Context for Fibrosarcoma of Bone

MalaCards organs/tissues related to Fibrosarcoma of Bone:

38
Bone

Publications for Fibrosarcoma of Bone

Articles related to Fibrosarcoma of Bone:

(show all 29)
# Title Authors Year
1
Primary sclerosing epithelioid fibrosarcoma of bone: analysis of a series. ( 24921641 )
2014
2
Malignant fibrous histiocytoma and fibrosarcoma of bone: a re-assessment in the light of currently employed morphological, immunohistochemical and molecular approaches. ( 23001328 )
2012
3
Frequent deletion of CDKN2A and recurrent coamplification of KIT, PDGFRA, and KDR in fibrosarcoma of bone--an array comparative genomic hybridization study. ( 19862822 )
2010
4
Tiling resolution array comparative genomic hybridization analysis of a fibrosarcoma of bone. ( 17175386 )
2007
5
Genetic analysis of fibrosarcoma of bone, a rare tumour entity closely related to osteosarcoma and malignant fibrous histiocytoma of bone. ( 15540465 )
2004
6
Metastatic secondary fibrosarcoma of bone responsive to repeated courses of Ifosfamide and associated with hypoglycemia. ( 18521374 )
2003
7
Clinicopathologic features, diagnosis, and treatment of fibrosarcoma of bone. ( 12041516 )
2002
8
Primary fibrosarcoma of bone. Outcome after primary surgical treatment. ( 10810466 )
2000
9
Multiple diffuse fibrosarcoma of bone. ( 10614764 )
1999
10
Multiple diffuse fibrosarcoma of bone associated with extramedullary hematopoiesis. ( 9652906 )
1998
11
Multiple diffuse fibrosarcoma of bone. ( 3843661 )
1985
12
Primary central (medullary) fibrosarcoma of bone. ( 6599928 )
1984
13
Definitions of osteosarcoma, chondrosarcoma, and fibrosarcoma of bone. ( 6930319 )
1980
14
Central fibrosarcoma of bone. Report of a case. ( 452904 )
1979
15
Fibrosarcoma of bone and soft tissues of the trunk and extremities. ( 917469 )
1977
16
Fibrosarcoma of bone. A study of 114 cases. ( 612638 )
1977
17
Fibrosarcoma of bone. A demographic, clinical and histopathological study of all cases recorded in the Swedish cancer registry from 1958 to 1968. ( 1071089 )
1976
18
Multiple diffuse fibrosarcoma of bone. ( 1253118 )
1976
19
A spectacular fibrosarcoma of bone. ( 1269140 )
1976
20
Metastatic spread of fibrosarcoma of bone; A report on forty-nine cases, and a comparison with osteosarcoma. ( 1071090 )
1976
21
Primary fibrosarcoma of bone. A clinicopathologic study of 130 patients. ( 1053940 )
1975
22
Fibrosarcoma of bone. A study of 114 cases. ( 5249422 )
1969
23
Fibrosarcoma of bone. Review of fifty consecutive cases from the Bristol Bone Tumour Registry. ( 5766357 )
1969
24
Medullary fibrosarcoma of bone. ( 5235191 )
1968
25
Primary medullary fibrosarcoma of bone: a case report. ( 13940805 )
1962
26
A bone tumour registry--chondrosarcoma and fibrosarcoma of bone. ( 13697723 )
1961
27
Central (medullary) fibrosarcoma of bone. ( 13491615 )
1958
28
Fibrosarcoma of bone. ( 13458607 )
1957
29
Multiple Diffuse Fibrosarcoma of Bone. ( 19970785 )
1944

Variations for Fibrosarcoma of Bone

Expression for Fibrosarcoma of Bone

Search GEO for disease gene expression data for Fibrosarcoma of Bone.

Pathways for Fibrosarcoma of Bone

Pathways related to Fibrosarcoma of Bone according to GeneCards Suite gene sharing:

(show all 34)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.65 CDK4 CDKN2A KDR KIT MDM2 MYC
2
Show member pathways
12.98 KDR KIT MDM2 NFATC2 PDGFRA PDGFRB
3
Show member pathways
12.69 CDK4 CDKN2A CREB3L2 KDR KIT MDM2
4 12.68 KDR KIT MYC PDGFRA PDGFRB
5
Show member pathways
12.68 CDK4 CREB3L2 KDR KIT MDM2 MYC
6 12.67 CDK4 CDKN2A KIT MDM2 MYC PDGFRA
7 12.42 CDKN2A MDM2 MYC PDGFRA PDGFRB
8
Show member pathways
12.37 KDR MDM2 PDGFRA PDGFRB
9
Show member pathways
12.3 CDK4 CDKN2A MDM2 MYC
10 12.29 CDK4 CDKN2A MDM2 MYC
11 12.21 CDK4 CDKN2A CREB3L2 MDM2
12 12.21 CDK4 CDKN2A MYC NFATC2 PDGFRA PDGFRB
13
Show member pathways
12.06 CDK4 CDKN2A MDM2 MYC
14 12.03 KDR KIT PDGFRA PDGFRB
15 12.03 CDK4 CDKN2A MDM2 MYC NFATC2
16 11.98 KDR MYC PDGFRB SERPINA1
17 11.9 CDKN2A MDM2 MYC
18 11.86 CDKN2A ING1 MDM2
19 11.77 KDR PDGFRA PDGFRB
20 11.76 CDK4 MDM2 MYC
21
Show member pathways
11.73 KDR KIT PDGFRB
22
Show member pathways
11.68 CDK4 CREB3L2 KDR MDM2 MYC PDGFRA
23 11.66 CDK4 CDKN2A MDM2 MYC
24 11.59 KIT MYC PDGFRA PDGFRB
25
Show member pathways
11.55 KDR KIT PDGFRA PDGFRB
26 11.5 KDR KIT PDGFRA
27 11.43 CDK4 MDM2 MYC
28 11.4 CDK4 MDM2 MYC
29 11.29 KDR MYC PDGFRA PDGFRB
30 11.22 CDK4 CDKN2A MDM2
31 11.15 CDK4 CDKN2A MDM2 MYC PDGFRA PDGFRB
32 11.04 CDKN2A MDM2 MYC
33
Show member pathways
11.03 CDKN2A MDM2 MYC
34 10.8 PDGFRA PDGFRB

GO Terms for Fibrosarcoma of Bone

Biological processes related to Fibrosarcoma of Bone according to GeneCards Suite gene sharing:

(show all 33)
# Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.95 CDK4 MDM2 MYC NFATC2
2 MAPK cascade GO:0000165 9.91 KIT MYC PDGFRA PDGFRB
3 positive regulation of gene expression GO:0010628 9.89 CDKN2A KIT MDM2 MYC NFATC2
4 positive regulation of cell migration GO:0030335 9.84 KDR KIT PDGFRA PDGFRB
5 response to toxic substance GO:0009636 9.81 CDK4 MDM2 PDGFRB
6 phosphatidylinositol phosphorylation GO:0046854 9.81 KIT PDGFRA PDGFRB
7 protein autophosphorylation GO:0046777 9.81 KDR KIT PDGFRA PDGFRB
8 G1/S transition of mitotic cell cycle GO:0000082 9.8 CDK4 CDKN2A MYC
9 peptidyl-tyrosine phosphorylation GO:0018108 9.78 KDR KIT PDGFRA PDGFRB
10 cell chemotaxis GO:0060326 9.73 KIT PDGFRA PDGFRB
11 positive regulation of cell proliferation GO:0008284 9.7 CDK4 KDR KIT MDM2 MYC PDGFRA
12 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.67 KDR KIT PDGFRA PDGFRB
13 response to hyperoxia GO:0055093 9.66 CDK4 PDGFRB
14 embryonic hemopoiesis GO:0035162 9.64 KDR KIT
15 cellular response to estrogen stimulus GO:0071391 9.62 MDM2 MYC
16 positive regulation of DNA biosynthetic process GO:2000573 9.62 MYC PDGFRB
17 cardiac myofibril assembly GO:0055003 9.61 PDGFRA PDGFRB
18 positive regulation of cell cycle GO:0045787 9.61 CDK4 MDM2 MYC
19 maintenance of gastrointestinal epithelium GO:0030277 9.6 MUC4 SERPINA3
20 somatic stem cell division GO:0048103 9.59 CDKN2A KIT
21 retina vasculature development in camera-type eye GO:0061298 9.58 PDGFRA PDGFRB
22 cellular response to phorbol 13-acetate 12-myristate GO:1904628 9.58 CDK4 MYC
23 amyloid fibril formation GO:1990000 9.57 CDKN2A MDM2
24 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.56 KDR KIT PDGFRA PDGFRB
25 negative regulation of platelet-derived growth factor receptor-beta signaling pathway GO:2000587 9.55 PDGFRA PDGFRB
26 positive regulation of phosphatidylinositol 3-kinase activity GO:0043552 9.5 KIT PDGFRA PDGFRB
27 metanephric glomerular capillary formation GO:0072277 9.46 PDGFRA PDGFRB
28 positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway GO:0038091 9.4 PDGFRA PDGFRB
29 positive regulation of fibroblast proliferation GO:0048146 9.26 CDK4 MYC PDGFRA PDGFRB
30 positive regulation of phospholipase C activity GO:0010863 8.8 KIT PDGFRA PDGFRB
31 protein phosphorylation GO:0006468 10.05 CDK4 KDR KIT PDGFRA PDGFRB
32 positive regulation of transcription, DNA-templated GO:0045893 10.04 CDKN2A CREB3L2 ING1 MYC NFATC2
33 phosphorylation GO:0016310 10 CDK4 CDKN2A KDR KIT PDGFRA PDGFRB

Molecular functions related to Fibrosarcoma of Bone according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 protein kinase activity GO:0004672 9.85 CDK4 KDR KIT PDGFRA PDGFRB
2 kinase activity GO:0016301 9.73 CDK4 CDKN2A KDR KIT PDGFRA PDGFRB
3 nucleotide binding GO:0000166 9.72 CDK4 CHD1L KIT PDGFRA PDGFRB
4 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 9.58 KIT PDGFRA PDGFRB
5 SUMO transferase activity GO:0019789 9.51 CDKN2A MDM2
6 platelet-derived growth factor receptor binding GO:0005161 9.49 PDGFRA PDGFRB
7 platelet-derived growth factor binding GO:0048407 9.48 PDGFRA PDGFRB
8 protein tyrosine kinase activity GO:0004713 9.46 KDR KIT PDGFRA PDGFRB
9 signal transducer, downstream of receptor, with protein tyrosine kinase activity GO:0004716 9.43 KDR KIT
10 vascular endothelial growth factor-activated receptor activity GO:0005021 9.37 KDR PDGFRA
11 vascular endothelial growth factor binding GO:0038085 8.96 PDGFRA PDGFRB
12 transmembrane receptor protein tyrosine kinase activity GO:0004714 8.92 KDR KIT PDGFRA PDGFRB

Sources for Fibrosarcoma of Bone

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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