MCID: FBR002
MIFTS: 40

Fibrosarcoma of Bone

Categories: Cancer diseases, Bone diseases

Aliases & Classifications for Fibrosarcoma of Bone

MalaCards integrated aliases for Fibrosarcoma of Bone:

Name: Fibrosarcoma of Bone 12 14
Fibrosarcoma of the Bone 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3354

Summaries for Fibrosarcoma of Bone

MalaCards based summary : Fibrosarcoma of Bone, also known as fibrosarcoma of the bone, is related to primary bone lymphoma and dedifferentiated liposarcoma. An important gene associated with Fibrosarcoma of Bone is PDGFRA (Platelet Derived Growth Factor Receptor Alpha), and among its related pathways/superpathways are GPCR Pathway and Phospholipase-C Pathway. The drugs Doxorubicin and Ifosfamide have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and lung, and related phenotypes are Decreased viability and cellular

Related Diseases for Fibrosarcoma of Bone

Diseases related to Fibrosarcoma of Bone via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 101)
id Related Disease Score Top Affiliating Genes
1 primary bone lymphoma 10.8 PDGFRA PDGFRB
2 dedifferentiated liposarcoma 10.8 KIT PDGFRA
3 bartholin's gland adenosquamous carcinoma 10.8 PDGFRA SERPINA3
4 myeloid neoplasms associated with pdgfrb rearrangement 10.8 PDGFRA PDGFRB
5 movement disease 10.7 KIT PDGFRA
6 punctate palmoplantar keratoderma type 2 10.7 KDR KIT PDGFRA
7 rete testis neoplasm 10.7 CDKN2A KDR PDGFRA
8 wilms tumor 6 10.7 KIT PDGFRA PDGFRB
9 desmoplastic small round cell tumor 10.7 KIT PDGFRA PDGFRB
10 gangliosidosis gm1 10.7 KIT MYC
11 alopecia antibody deficiency 10.7 KIT PDGFRA PDGFRB
12 cask-related intellectual disability 10.6 KDR KIT PDGFRB
13 mitral valve stenosis 10.6 KDR KIT PDGFRB
14 retroperitoneal leiomyosarcoma 10.6 KIT PDGFRA
15 temporal lobe epilepsy 10.6 KIT PDGFRA PDGFRB
16 hypereosinophilic syndrome, idiopathic, resistant to imatinib 10.6 KIT PDGFRA PDGFRB
17 benign mammary dysplasia 10.6 KIT PDGFRA PDGFRB
18 thrombocythemia 3 10.5 KIT PDGFRA PDGFRB
19 rnase t2-deficient leukoencephalopathy 10.5 CDK4 MDM2
20 chikungunya 10.5 KDR KIT MYC
21 nelson syndrome 10.5 KIT PDGFRA PDGFRB
22 anus leiomyoma 10.5 CALD1 KIT
23 exertional headache 10.5 CDK4 CDKN2A KIT
24 vagina, absence of 10.5 KIT MDM2 PDGFRB
25 18p deletion syndrome 10.5 KIT PDGFRA PDGFRB
26 superficial basal cell carcinoma 10.5 CDKN2A KIT
27 rhabdoid cancer 10.5 KIT SERPINA1 SERPINA3
28 gastrointestinal stromal tumor 10.4 CDKN2A KIT PDGFRA PDGFRB
29 dubin-johnson syndrome 10.4 CDK4 CDKN2A KIT
30 epidural neoplasm 10.4 CDK4 CDKN2A MDM2
31 skin lipoma 10.4 CDK4 MDM2
32 gallbladder cancer 10.4 CDKN2A KIT MYC PDGFRA
33 juxtacortical chondrosarcoma 10.4 CDK4 CDKN2A MDM2
34 neurofibroma of the esophagus 10.4 CDK4 CDKN2A MDM2
35 primary pulmonary lymphoma 10.4 CDK4 MDM2 SERPINA3
36 coronary aneurysm 10.4 CDK4 MDM2
37 secondary pulmonary hemosiderosis 10.4 CDK4 CDKN2A MDM2
38 diencephalic astrocytomas 10.3 CDK4 CDKN2A KDR
39 malignant giant cell tumor of the tendon sheath 10.3 PTER SERPINA3
40 fibrosarcoma 10.3
41 peroxisome biogenesis disorder 7a 10.3 KIT MYC PDGFRA PDGFRB
42 sublingual gland adenoid cystic carcinoma 10.3 CALD1 KIT
43 bladder urachal squamous cell carcinoma 10.3 CDK4 CDKN2A KIT PDGFRA
44 rectum squamous cell carcinoma 10.3 CDKN2A MDM2
45 accessory nerve disease 10.3 CDK4 CDKN2A MDM2
46 sleep disorder 10.3 MDM2 SERPINA1 SERPINA3
47 metachronous osteosarcoma of the bone 10.3 CDK4 MDM2
48 villous adenoma 10.3 CDKN2A MDM2 MYC
49 kala-azar 1 10.2 KIT MDM2 PDGFRA PDGFRB
50 sarcoma 10.2 CREB3L2 KIT

Graphical network of the top 20 diseases related to Fibrosarcoma of Bone:



Diseases related to Fibrosarcoma of Bone

Symptoms & Phenotypes for Fibrosarcoma of Bone

GenomeRNAi Phenotypes related to Fibrosarcoma of Bone according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00173-A 9.88 PDGFRA
2 Decreased viability GR00221-A-1 9.88 PDGFRB CDKN2A KDR MYC PDGFRA KIT
3 Decreased viability GR00221-A-2 9.88 KDR
4 Decreased viability GR00221-A-3 9.88 PDGFRB CDKN2A KDR MYC PDGFRA
5 Decreased viability GR00221-A-4 9.88 PDGFRB CDKN2A KDR PDGFRA
6 Decreased viability GR00301-A 9.88 KIT
7 Decreased viability GR00342-S-1 9.88 PDGFRB
8 Decreased substrate adherent cell growth GR00193-A-1 9.5 KIT
9 Decreased substrate adherent cell growth GR00193-A-2 9.5 CDK4 KIT
10 Decreased substrate adherent cell growth GR00193-A-3 9.5 CDK4
11 Decreased substrate adherent cell growth GR00193-A-4 9.5 CDK4 KDR KIT

MGI Mouse Phenotypes related to Fibrosarcoma of Bone:

44 (show all 16)
id Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.28 STARD13 CDK4 CDKN2A ING1 KDR KIT
2 behavior/neurological MP:0005386 10.26 CDK4 CDKN2A ING1 KDR KIT MDM2
3 growth/size/body region MP:0005378 10.23 CDK4 CDKN2A CREB3L2 ING1 KDR KIT
4 cardiovascular system MP:0005385 10.2 KIT MDM2 MYC PDGFRA PDGFRB STARD13
5 endocrine/exocrine gland MP:0005379 10.18 CDK4 CDKN2A ING1 KIT MDM2 MYC
6 hematopoietic system MP:0005397 10.17 KDR KIT MDM2 MYC NFATC2 PDGFRA
7 embryo MP:0005380 10.15 CDK4 CDKN2A KDR KIT MDM2 MYC
8 immune system MP:0005387 10.14 CDK4 CDKN2A ING1 KDR KIT MDM2
9 digestive/alimentary MP:0005381 10.11 CDKN2A CREB3L2 KIT MDM2 MYC PDGFRA
10 craniofacial MP:0005382 10.07 CREB3L2 KIT MDM2 MYC NFATC2 PDGFRA
11 integument MP:0010771 9.97 CDK4 CDKN2A KDR KIT MDM2 MYC
12 muscle MP:0005369 9.91 NFATC2 PDGFRA PDGFRB CDK4 CDKN2A KDR
13 limbs/digits/tail MP:0005371 9.8 CREB3L2 KIT MDM2 MYC PDGFRA PDGFRB
14 neoplasm MP:0002006 9.76 CDK4 CDKN2A ING1 KIT MDM2 MYC
15 pigmentation MP:0001186 9.43 CDK4 CDKN2A KIT MDM2 MYC PDGFRA
16 skeleton MP:0005390 9.28 CDKN2A CREB3L2 KDR KIT MDM2 MYC

Drugs & Therapeutics for Fibrosarcoma of Bone

Drugs for Fibrosarcoma of Bone (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 70)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Doxorubicin Approved, Investigational Phase 3,Phase 2,Phase 1 23214-92-8 31703
2
Ifosfamide Approved Phase 3,Phase 2 3778-73-2 3690
3
Mechlorethamine Approved Phase 3,Phase 2 51-75-2 4033
4
Carboplatin Approved Phase 3,Phase 2 41575-94-4 10339178 498142 38904
5
Cyclophosphamide Approved, Investigational Phase 3,Phase 2 50-18-0, 6055-19-2 2907
6
Dactinomycin Approved Phase 3,Phase 2 50-76-0 2019 457193
7
Epirubicin Approved Phase 3 56420-45-2 41867
8
Etoposide Approved Phase 3,Phase 2 33419-42-0 36462
9
Vincristine Approved, Investigational Phase 3,Phase 2 2068-78-2, 57-22-7 5978
10
Doxil Approved June 1999 Phase 3,Phase 2,Phase 1 31703
11 Alkylating Agents Phase 3,Phase 2
12 Anti-Bacterial Agents Phase 3,Phase 2,Phase 1
13 Antibiotics, Antitubercular Phase 3,Phase 2,Phase 1
14 Isophosphamide mustard Phase 3,Phase 2
15 Topoisomerase Inhibitors Phase 3,Phase 2,Phase 1
16 Anti-Infective Agents Phase 3,Phase 2
17 Antimitotic Agents Phase 3,Phase 1,Phase 2
18 Antineoplastic Agents, Phytogenic Phase 3,Phase 2,Phase 1
19 Antirheumatic Agents Phase 3,Phase 2,Phase 1
20 Etoposide phosphate Phase 3,Phase 2
21 Immunosuppressive Agents Phase 3,Phase 2
22 Nucleic Acid Synthesis Inhibitors Phase 3,Phase 2
23 Thiotepa Approved Phase 2 52-24-4 5453
24
Lenograstim Approved Phase 2 135968-09-1
25
Topotecan Approved, Investigational Phase 2 119413-54-6, 123948-87-8 60700
26
Sunitinib Approved, Investigational Phase 2 341031-54-7, 557795-19-4 5329102
27
Dacarbazine Approved, Investigational Phase 2 4342-03-4 5351166
28
Sorafenib Approved, Investigational Phase 2 284461-73-0 216239 406563
29
Romidepsin Approved, Investigational Phase 2 128517-07-7 5352062
30
Everolimus Approved Phase 2 159351-69-6 6442177
31
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
32
Sirolimus Approved, Investigational Phase 2 53123-88-9 5284616 6436030 46835353
33
Dasatinib Approved, Investigational Phase 2 302962-49-8 3062316
34
Paclitaxel Approved, Vet_approved Phase 1, Phase 2 33069-62-4 36314
35
Mesna Approved Phase 2 3375-50-6 598
36
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
37
Niacin Approved, Investigational, Nutraceutical Phase 2 59-67-6 938
38
Nicotinamide Approved, Nutraceutical Phase 2 98-92-0 936
39
Camptothecin Experimental Phase 2 7689-03-4
40 Exatecan Investigational Phase 2 171335-80-1
41 Imatinib Mesylate Phase 2 123596
42 Protein Kinase Inhibitors Phase 2
43 Liver Extracts Phase 2
44 topoisomerase I inhibitors Phase 2
45 Angiogenesis Inhibitors Phase 2
46 Angiogenesis Modulating Agents Phase 2
47 Micronutrients Phase 2
48 Nicotinic Acids Phase 2
49 Trace Elements Phase 2
50 Vitamin B Complex Phase 2

Interventional clinical trials:

(show all 22)

id Name Status NCT ID Phase Drugs
1 Ifosfamide and Doxorubicin, Radiation Therapy, and/or Surgery in Treating Young Patients With Localized Soft Tissue Sarcoma Unknown status NCT00334854 Phase 3 doxorubicin hydrochloride;ifosfamide
2 Surgery Followed by Chemotherapy in Treating Young Patients With Soft Tissue Sarcoma Completed NCT00002898 Phase 3 carboplatin;cyclophosphamide;epirubicin hydrochloride;etoposide;ifosfamide;vincristine sulfate
3 Observation, Radiation Therapy, Combination Chemotherapy, and/or Surgery in Treating Young Patients With Soft Tissue Sarcoma Completed NCT00346164 Phase 3 doxorubicin hydrochloride;ifosfamide
4 Radiation Therapy With or Without Combination Chemotherapy or Pazopanib Hydrochloride Before Surgery in Treating Patients With Newly Diagnosed Non-rhabdomyosarcoma Soft Tissue Sarcomas That Can Be Removed by Surgery Recruiting NCT02180867 Phase 2, Phase 3 Doxorubicin Hydrochloride;Ifosfamide;Pazopanib Hydrochloride
5 Randomised Trial of Volume of Post-operative Radiotherapy Given to Adult Patients With eXtremity Soft Tissue Sarcoma Active, not recruiting NCT00423618 Phase 3
6 Safety and Efficacy Study of REOLYSIN® in the Treatment of Bone and Soft Tissue Sarcomas Metastatic to the Lung Completed NCT00503295 Phase 2
7 Study of High-Dose Chemotherapy With Bone Marrow or Stem Cell Transplant for Rare Poor-Prognosis Cancers Completed NCT00141765 Phase 2
8 Imatinib Mesylate in Treating Patients With Advanced Soft Tissue Sarcoma or Bone Sarcoma Completed NCT00031915 Phase 2 imatinib mesylate
9 Combination Chemotherapy Followed by Bone Marrow Transplantation in Treating Patients With Rare Cancer Completed NCT00002515 Phase 2 carboplatin;thiotepa;topotecan hydrochloride
10 Exatecan Mesylate in Treating Patients With Advanced Soft Tissue Sarcoma Completed NCT00041236 Phase 2 exatecan mesylate
11 Vismodegib and Gamma-Secretase/Notch Signalling Pathway Inhibitor RO4929097 in Treating Patients With Advanced or Metastatic Sarcoma Completed NCT01154452 Phase 1, Phase 2 Gamma-Secretase Inhibitor RO4929097;Vismodegib
12 Sunitinib in Treating Patients With Metastatic, Locally Advanced, or Locally Recurrent Sarcomas Completed NCT00474994 Phase 2 sunitinib malate
13 Sorafenib and Dacarbazine in Soft Tissue Sarcoma Completed NCT00837148 Phase 2 Sorafenib and Dacarbazine
14 Depsipeptide (Romidepsin) in Treating Patients With Metastatic or Unresectable Soft Tissue Sarcoma Completed NCT00112463 Phase 2 romidepsin
15 Cixutumumab and Temsirolimus in Treating Younger Patients With Recurrent or Refractory Sarcoma Active, not recruiting NCT01614795 Phase 2 temsirolimus
16 Trial of Dasatinib in Advanced Sarcomas Active, not recruiting NCT00464620 Phase 2 Dasatinib
17 To Find a Safe Dose and Show Early Clinical Activity of Weekly Nab-paclitaxel in Pediatric Patients With Recurrent/ Refractory Solid Tumors Active, not recruiting NCT01962103 Phase 1, Phase 2 nab-paclitaxel
18 Surgery and/or Chemotherapy in Treating Children With Infantile, Congenital, or Childhood Fibrosarcoma Terminated NCT00072280 Phase 2 cyclophosphamide;etoposide;ifosfamide;vincristine sulfate
19 Celecoxib and Radiation Therapy in Treating Patients With Stage II or Stage III Soft Tissue Sarcoma of the Arm, Hand, Leg, or Foot That Has Been Removed by Surgery Completed NCT00450736 Phase 1 celecoxib
20 Cixutumumab and Doxorubicin Hydrochloride in Treating Patients With Unresectable, Locally Advanced, or Metastatic Soft Tissue Sarcoma Completed NCT00720174 Phase 1 Doxorubicin Hydrochloride
21 Natural History Study of Patients With Neurofibromatosis Type I Recruiting NCT00924196
22 Glutamine in Preventing Oral Mucositis in Patients Receiving Chemotherapy for Sarcoma Withdrawn NCT00334984 glutamine

Search NIH Clinical Center for Fibrosarcoma of Bone

Genetic Tests for Fibrosarcoma of Bone

Anatomical Context for Fibrosarcoma of Bone

MalaCards organs/tissues related to Fibrosarcoma of Bone:

39
Bone, Bone Marrow, Lung, Liver

Publications for Fibrosarcoma of Bone

Articles related to Fibrosarcoma of Bone:

(show all 29)
id Title Authors Year
1
Primary sclerosing epithelioid fibrosarcoma of bone: analysis of a series. ( 24921641 )
2014
2
Malignant fibrous histiocytoma and fibrosarcoma of bone: a re-assessment in the light of currently employed morphological, immunohistochemical and molecular approaches. ( 23001328 )
2012
3
Frequent deletion of CDKN2A and recurrent coamplification of KIT, PDGFRA, and KDR in fibrosarcoma of bone--an array comparative genomic hybridization study. ( 19862822 )
2010
4
Tiling resolution array comparative genomic hybridization analysis of a fibrosarcoma of bone. ( 17175386 )
2007
5
Genetic analysis of fibrosarcoma of bone, a rare tumour entity closely related to osteosarcoma and malignant fibrous histiocytoma of bone. ( 15540465 )
2004
6
Metastatic secondary fibrosarcoma of bone responsive to repeated courses of Ifosfamide and associated with hypoglycemia. ( 18521374 )
2003
7
Clinicopathologic features, diagnosis, and treatment of fibrosarcoma of bone. ( 12041516 )
2002
8
Primary fibrosarcoma of bone. Outcome after primary surgical treatment. ( 10810466 )
2000
9
Multiple diffuse fibrosarcoma of bone. ( 10614764 )
1999
10
Multiple diffuse fibrosarcoma of bone associated with extramedullary hematopoiesis. ( 9652906 )
1998
11
Multiple diffuse fibrosarcoma of bone. ( 3843661 )
1985
12
Primary central (medullary) fibrosarcoma of bone. ( 6599928 )
1984
13
Definitions of osteosarcoma, chondrosarcoma, and fibrosarcoma of bone. ( 6930319 )
1980
14
Central fibrosarcoma of bone. Report of a case. ( 452904 )
1979
15
Fibrosarcoma of bone. A study of 114 cases. ( 612638 )
1977
16
Fibrosarcoma of bone and soft tissues of the trunk and extremities. ( 917469 )
1977
17
Multiple diffuse fibrosarcoma of bone. ( 1253118 )
1976
18
A spectacular fibrosarcoma of bone. ( 1269140 )
1976
19
Fibrosarcoma of bone. A demographic, clinical and histopathological study of all cases recorded in the Swedish cancer registry from 1958 to 1968. ( 1071089 )
1976
20
Metastatic spread of fibrosarcoma of bone; A report on forty-nine cases, and a comparison with osteosarcoma. ( 1071090 )
1976
21
Primary fibrosarcoma of bone. A clinicopathologic study of 130 patients. ( 1053940 )
1975
22
Fibrosarcoma of bone. Review of fifty consecutive cases from the Bristol Bone Tumour Registry. ( 5766357 )
1969
23
Fibrosarcoma of bone. A study of 114 cases. ( 5249422 )
1969
24
Medullary fibrosarcoma of bone. ( 5235191 )
1968
25
Primary medullary fibrosarcoma of bone: a case report. ( 13940805 )
1962
26
A bone tumour registry--chondrosarcoma and fibrosarcoma of bone. ( 13697723 )
1961
27
Central (medullary) fibrosarcoma of bone. ( 13491615 )
1958
28
Fibrosarcoma of bone. ( 13458607 )
1957
29
Multiple Diffuse Fibrosarcoma of Bone. ( 19970785 )
1944

Variations for Fibrosarcoma of Bone

Expression for Fibrosarcoma of Bone

Search GEO for disease gene expression data for Fibrosarcoma of Bone.

Pathways for Fibrosarcoma of Bone

Pathways related to Fibrosarcoma of Bone according to GeneCards Suite gene sharing:

(show all 29)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.62 CDK4 CDKN2A KDR KIT MDM2 MYC
2
Show member pathways
12.96 KDR KIT MDM2 NFATC2 PDGFRA PDGFRB
3 12.46 CDK4 CREB3L2 KDR KIT MDM2 MYC
4 12.4 CDKN2A MDM2 MYC PDGFRA PDGFRB
5 12.4 CDK4 CDKN2A KIT MDM2 MYC PDGFRA
6
Show member pathways
12.36 KDR MDM2 PDGFRA PDGFRB
7
Show member pathways
12.28 CDK4 CDKN2A MDM2 MYC
8 12.27 CDK4 CDKN2A MDM2 MYC
9 12.25 CDK4 CDKN2A MYC NFATC2 PDGFRA PDGFRB
10 12.19 CDK4 CDKN2A CREB3L2 MDM2
11
Show member pathways
12.16 CDK4 CDKN2A CREB3L2 KDR KIT MDM2
12 12 KDR KIT PDGFRA PDGFRB
13 11.96 KDR MYC PDGFRB SERPINA1
14 11.84 CDKN2A ING1 MDM2
15 11.75 CDK4 MDM2 MYC
16 11.74 KDR PDGFRA PDGFRB
17
Show member pathways
11.71 KDR KIT PDGFRB
18
Show member pathways
11.71 CDK4 CREB3L2 KDR MDM2 MYC PDGFRA
19 11.62 CDK4 CDKN2A MDM2 MYC
20
Show member pathways
11.59 KDR KIT PDGFRA PDGFRB
21 11.52 KIT MYC PDGFRA PDGFRB
22 11.48 KDR KIT PDGFRA
23 11.41 CDK4 MDM2 MYC
24 11.38 CDK4 MDM2 MYC
25 11.19 CDK4 CDKN2A MDM2
26 11.15 CDK4 CDKN2A MDM2 MYC PDGFRA PDGFRB
27 11.01 CDKN2A MDM2 MYC
28
Show member pathways
11 CDKN2A MDM2 MYC
29 10.78 PDGFRA PDGFRB

GO Terms for Fibrosarcoma of Bone

Biological processes related to Fibrosarcoma of Bone according to GeneCards Suite gene sharing:

(show all 29)
id Name GO ID Score Top Affiliating Genes
1 phosphorylation GO:0016310 9.99 CDK4 CDKN2A KDR KIT PDGFRA PDGFRB
2 MAPK cascade GO:0000165 9.91 KIT MYC PDGFRA PDGFRB
3 positive regulation of cell migration GO:0030335 9.83 KDR KIT PDGFRA PDGFRB
4 phosphatidylinositol-mediated signaling GO:0048015 9.82 KIT PDGFRA PDGFRB
5 response to toxic substance GO:0009636 9.8 CDK4 MDM2 PDGFRB
6 phosphatidylinositol phosphorylation GO:0046854 9.8 KIT PDGFRA PDGFRB
7 protein autophosphorylation GO:0046777 9.8 KDR KIT PDGFRA PDGFRB
8 G1/S transition of mitotic cell cycle GO:0000082 9.79 CDK4 CDKN2A MYC
9 positive regulation of gene expression GO:0010628 9.78 KIT MDM2 MYC NFATC2
10 regulation of phosphatidylinositol 3-kinase signaling GO:0014066 9.77 KIT PDGFRA PDGFRB
11 peptidyl-tyrosine phosphorylation GO:0018108 9.76 KDR KIT PDGFRA PDGFRB
12 cell chemotaxis GO:0060326 9.73 KIT PDGFRA PDGFRB
13 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.67 KDR KIT PDGFRA PDGFRB
14 response to hyperoxia GO:0055093 9.64 CDK4 PDGFRB
15 embryonic hemopoiesis GO:0035162 9.63 KDR KIT
16 positive regulation of DNA biosynthetic process GO:2000573 9.61 MYC PDGFRB
17 maintenance of gastrointestinal epithelium GO:0030277 9.6 MUC4 SERPINA3
18 cardiac myofibril assembly GO:0055003 9.58 PDGFRA PDGFRB
19 somatic stem cell division GO:0048103 9.58 CDKN2A KIT
20 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.56 KDR KIT PDGFRA PDGFRB
21 retina vasculature development in camera-type eye GO:0061298 9.55 PDGFRA PDGFRB
22 negative regulation of platelet-derived growth factor receptor-beta signaling pathway GO:2000587 9.54 PDGFRA PDGFRB
23 positive regulation of phosphatidylinositol 3-kinase activity GO:0043552 9.5 KIT PDGFRA PDGFRB
24 positive regulation of cell proliferation GO:0008284 9.5 CDK4 KDR KIT MDM2 MYC PDGFRA
25 positive regulation of fibroblast proliferation GO:0048146 9.46 CDK4 MYC PDGFRA PDGFRB
26 metanephric glomerular capillary formation GO:0072277 9.43 PDGFRA PDGFRB
27 positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway GO:0038091 9.4 PDGFRA PDGFRB
28 amyloid fibril formation GO:1990000 9.27 MDM2
29 positive regulation of phospholipase C activity GO:0010863 8.8 KIT PDGFRA PDGFRB

Molecular functions related to Fibrosarcoma of Bone according to GeneCards Suite gene sharing:

(show all 11)
id Name GO ID Score Top Affiliating Genes
1 protein kinase activity GO:0004672 9.88 CDK4 KDR KIT PDGFRA PDGFRB
2 kinase activity GO:0016301 9.73 CDK4 CDKN2A KDR KIT PDGFRA PDGFRB
3 nucleotide binding GO:0000166 9.72 CDK4 CHD1L KIT PDGFRA PDGFRB
4 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 9.58 KIT PDGFRA PDGFRB
5 platelet-derived growth factor receptor binding GO:0005161 9.49 PDGFRA PDGFRB
6 platelet-derived growth factor binding GO:0048407 9.46 PDGFRA PDGFRB
7 protein tyrosine kinase activity GO:0004713 9.46 KDR KIT PDGFRA PDGFRB
8 signal transducer, downstream of receptor, with protein tyrosine kinase activity GO:0004716 9.43 KDR KIT
9 vascular endothelial growth factor-activated receptor activity GO:0005021 9.37 KDR PDGFRA
10 vascular endothelial growth factor binding GO:0038085 8.96 PDGFRA PDGFRB
11 transmembrane receptor protein tyrosine kinase activity GO:0004714 8.92 KDR KIT PDGFRA PDGFRB

Sources for Fibrosarcoma of Bone

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
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48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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