MCID: FBR016
MIFTS: 25

Fibrosclerosis of Breast malady

Categories: Reproductive diseases, Cancer diseases

Aliases & Classifications for Fibrosclerosis of Breast

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Aliases & Descriptions for Fibrosclerosis of Breast:

Name: Fibrosclerosis of Breast 11 13
 
Fibrosis of the Breast 11

Classifications:



External Ids:

Disease Ontology11 DOID:10353
ICD1030 N60.3
SNOMED-CT62 29070004
ICD9CM32 610.3
NCIt45 C3660

Summaries for Fibrosclerosis of Breast

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Wikipedia:71 Fibrosclerosis of the breast is most frequently used to mean sclerosing lobular adenosis of the breast.... more...

MalaCards based summary: Fibrosclerosis of Breast, also known as fibrosis of the breast, is related to multiple epiphyseal dysplasia and holoprosencephaly. An important gene associated with Fibrosclerosis of Breast is XRCC1 (X-Ray Repair Cross Complementing 1), and among its related pathways are TGF-beta Receptor Signaling Pathway and Wnt / Hedgehog / Notch. Affiliated tissues include breast and skin, and related mouse phenotypes are embryo and neoplasm.

Related Diseases for Fibrosclerosis of Breast

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Diseases related to Fibrosclerosis of Breast via text searches within MalaCards or GeneCards Suite gene sharing:

idRelated DiseaseScoreTop Affiliating Genes
1multiple epiphyseal dysplasia9.7ENG, TGFB1
2holoprosencephaly9.7ENG, TGFB1
3glomerulosclerosis, focal segmental, 79.6ENG, TGFB1
4mastitis9.6
5diabetic mastopathy9.6
6multiple synostoses syndrome9.5SRY, TGFB1
7apocrine adenosis of breast8.7ENG, NPM1, SRY, XRCC1
8eosinophilic meningitis8.3ENG, NPM1, SRY, TGFB1, XRCC1

Graphical network of diseases related to Fibrosclerosis of Breast:



Diseases related to fibrosclerosis of breast

Symptoms & Phenotypes for Fibrosclerosis of Breast

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MGI Mouse Phenotypes related to Fibrosclerosis of Breast according to GeneCards Suite gene sharing:

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idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053808.7ENG, NPM1, TGFB1, XRCC1
2MP:00020068.7NPM1, TGFB1, XRCC1

Drugs & Therapeutics for Fibrosclerosis of Breast

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Interventional clinical trials:

idNameStatusNCT IDPhase
1Shandong Cancer Hospital Affiliated to Shandong UniversityRecruitingNCT02958033Phase 3
2Partial Breast Irradiation (PBI) for Selected Patients With Early Breast CancerActive, not recruitingNCT00325598Phase 1, Phase 2
3Partial Breast Irradiation (PBI) for Selected Patients With Early Invasive or Non-Invasive Breast CancerActive, not recruitingNCT00694577Phase 1
4Radiation Therapy Followed by Surgery in Treating Patients With Early-Stage Breast CancerRecruitingNCT01024582
5Trial Comparing Prone and Supine Intensity-modulated Radiotherapy (IMRT) After Breast-conserving Surgery in Patients With Large Breast Volume at High Risk for Skin Toxicity and FibrosisRecruitingNCT00887523

Search NIH Clinical Center for Fibrosclerosis of Breast

Genetic Tests for Fibrosclerosis of Breast

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Anatomical Context for Fibrosclerosis of Breast

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MalaCards organs/tissues related to Fibrosclerosis of Breast:

36
Breast, Skin

Publications for Fibrosclerosis of Breast

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Variations for Fibrosclerosis of Breast

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Expression for genes affiliated with Fibrosclerosis of Breast

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Search GEO for disease gene expression data for Fibrosclerosis of Breast.

Pathways for genes affiliated with Fibrosclerosis of Breast

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GO Terms for genes affiliated with Fibrosclerosis of Breast

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Biological processes related to Fibrosclerosis of Breast according to GeneCards Suite gene sharing:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1cellular response to mechanical stimulusGO:007126010.1ENG, TGFB1
2negative regulation of gene expressionGO:001062910.0ENG, TGFB1
3positive regulation of collagen biosynthetic processGO:003296710.0ENG, TGFB1
4positive regulation of pathway-restricted SMAD protein phosphorylationGO:001086210.0ENG, TGFB1
5positive regulation of protein phosphorylationGO:000193410.0ENG, TGFB1
6response to hypoxiaGO:000166610.0TGFB1, XRCC1
7regulation of transforming growth factor beta receptor signaling pathwayGO:00170159.9ENG, TGFB1
8positive regulation of NF-kappaB transcription factor activityGO:00510929.8NPM1, TGFB1
9response to organic substanceGO:00100339.5TGFB1, XRCC1
10positive regulation of transcription, DNA-templatedGO:00458939.2NPM1, SRY, TGFB1

Molecular functions related to Fibrosclerosis of Breast according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1type I transforming growth factor beta receptor bindingGO:00347139.5ENG, TGFB1
2enzyme bindingGO:00198999.4NPM1, TGFB1, XRCC1
3type II transforming growth factor beta receptor bindingGO:00051149.3ENG, TGFB1
4protein heterodimerization activityGO:00469829.3NPM1, SRY, TGFB1
5protein homodimerization activityGO:00428038.8ENG, NPM1, TGFB1

Sources for Fibrosclerosis of Breast

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet