MCID: FBR016
MIFTS: 23

Fibrosclerosis of Breast malady

Reproductive diseases, Cancer diseases categories

Aliases & Classifications for Fibrosclerosis of Breast

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Aliases & Descriptions for Fibrosclerosis of Breast:

Name: Fibrosclerosis of Breast 10 65
 
Fibrosis of the Breast 10


Classifications:



External Ids:

Disease Ontology10 DOID:10353
ICD9CM29 610.3
SNOMED-CT59 29070004
NCIt42 C3660
ICD1027 N60.3

Summaries for Fibrosclerosis of Breast

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Wikipedia:68 Fibrosclerosis of the breast is most frequently used to mean sclerosing lobular adenosis of the breast.... more...

MalaCards based summary: Fibrosclerosis of Breast, also known as fibrosis of the breast, is related to mastitis and diabetic mastopathy. An important gene associated with Fibrosclerosis of Breast is XRCC1 (X-Ray Repair Complementing Defective Repair In Chinese Hamster Cells 1), and among its related pathways are and . Affiliated tissues include breast and skin, and related mouse phenotypes are embryogenesis and tumorigenesis.

Related Diseases for Fibrosclerosis of Breast

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Graphical network of diseases related to Fibrosclerosis of Breast:



Diseases related to fibrosclerosis of breast

Symptoms for Fibrosclerosis of Breast

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Drugs & Therapeutics for Fibrosclerosis of Breast

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Interventional clinical trials:

idNameStatusNCT IDPhase
1Partial Breast Irradiation (PBI) for Selected Patients With Early Breast CancerActive, not recruitingNCT00325598Phase 1, Phase 2
2Partial Breast Irradiation (PBI) for Selected Patients With Early Invasive or Non-Invasive Breast CancerActive, not recruitingNCT00694577Phase 1
3Radiation Therapy Followed by Surgery in Treating Patients With Early-Stage Breast CancerRecruitingNCT01024582
4Trial Comparing Prone and Supine Intensity-modulated Radiotherapy (IMRT) After Breast-conserving Surgery in Patients With Large Breast Volume at High Risk for Skin Toxicity and FibrosisRecruitingNCT00887523

Search NIH Clinical Center for Fibrosclerosis of Breast

Genetic Tests for Fibrosclerosis of Breast

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Anatomical Context for Fibrosclerosis of Breast

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MalaCards organs/tissues related to Fibrosclerosis of Breast:

33
Breast, Skin

Animal Models for Fibrosclerosis of Breast or affiliated genes

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MGI Mouse Phenotypes related to Fibrosclerosis of Breast:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053808.5ENG, NPM1, TGFB1, XRCC1
2MP:00020068.1NPM1, TGFB1, TGFBI, XRCC1
3MP:00053847.8ENG, NPM1, TGFB1, TGFBI, XRCC1
4MP:00053787.3ENG, NPM1, TGFB1, TGFBI, XRCC1
5MP:00107687.0ENG, NPM1, SRY, TGFB1, TGFBI, XRCC1

Publications for Fibrosclerosis of Breast

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Variations for Fibrosclerosis of Breast

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Expression for genes affiliated with Fibrosclerosis of Breast

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Search GEO for disease gene expression data for Fibrosclerosis of Breast.

Pathways for genes affiliated with Fibrosclerosis of Breast

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Pathways related to Fibrosclerosis of Breast according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Angiogenesis (CST)
Show member pathways
9.5
2
TGF-beta Signaling Pathway (sino)
Show member pathways
9.5
39.5ENG, TGFB1
49.5ENG, TGFB1
59.4ENG, NPM1
68.7ENG, TGFB1, TGFBI

GO Terms for genes affiliated with Fibrosclerosis of Breast

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Biological processes related to Fibrosclerosis of Breast according to GeneCards Suite gene sharing:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1regulation of transforming growth factor beta receptor signaling pathwayGO:001701510.0ENG, TGFB1
2positive regulation of pathway-restricted SMAD protein phosphorylationGO:001086210.0ENG, TGFB1
3negative regulation of transforming growth factor beta receptor signaling pathwayGO:00305129.9ENG, TGFB1
4positive regulation of NF-kappaB transcription factor activityGO:00510929.7NPM1, TGFB1
5response to organic substanceGO:00100339.5TGFB1, XRCC1
6transforming growth factor beta receptor signaling pathwayGO:00071799.4ENG, TGFB1
7wound healingGO:00420609.2ENG, TGFB1
8response to hypoxiaGO:00016669.2ENG, TGFB1, XRCC1
9chondrocyte differentiationGO:00020629.1TGFB1, TGFBI
10positive regulation of transcription, DNA-templatedGO:00458939.0NPM1, SRY, TGFB1

Molecular functions related to Fibrosclerosis of Breast according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1type I transforming growth factor beta receptor bindingGO:003471310.0ENG, TGFB1
2type II transforming growth factor beta receptor bindingGO:000511410.0ENG, TGFB1
3protein heterodimerization activityGO:00469828.8NPM1, SRY, TGFB1

Sources for Fibrosclerosis of Breast

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet