MCID: FBR016
MIFTS: 24

Fibrosclerosis of Breast malady

Categories: Reproductive diseases, Cancer diseases

Aliases & Classifications for Fibrosclerosis of Breast

About this section

Aliases & Descriptions for Fibrosclerosis of Breast:

Name: Fibrosclerosis of Breast 11 13
 
Fibrosis of the Breast 11

Classifications:



External Ids:

Disease Ontology11 DOID:10353
ICD1030 N60.3
SNOMED-CT62 29070004
ICD9CM32 610.3
NCIt45 C3660

Summaries for Fibrosclerosis of Breast

About this section
Wikipedia:71 Fibrosclerosis of the breast is most frequently used to mean sclerosing lobular adenosis of the breast.... more...

MalaCards based summary: Fibrosclerosis of Breast, also known as fibrosis of the breast, is related to glomerulosclerosis, focal segmental, 7 and respiratory syncytial virus infectious disease. An important gene associated with Fibrosclerosis of Breast is XRCC1 (X-Ray Repair Cross Complementing 1), and among its related pathways are TGF-beta Signaling Pathways and Wnt / Hedgehog / Notch. Affiliated tissues include breast, and related mouse phenotype embryo.

Related Diseases for Fibrosclerosis of Breast

About this section

Graphical network of diseases related to Fibrosclerosis of Breast:



Diseases related to fibrosclerosis of breast

Symptoms & Phenotypes for Fibrosclerosis of Breast

About this section

MGI Mouse Phenotypes related to Fibrosclerosis of Breast according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053808.2ENG, NPM1, TGFB1, XRCC1

Drugs & Therapeutics for Fibrosclerosis of Breast

About this section

Interventional clinical trials:

idNameStatusNCT IDPhase
1Shandong Cancer Hospital Affiliated to Shandong UniversityRecruitingNCT02958033Phase 3
2Partial Breast Irradiation (PBI) for Selected Patients With Early Breast CancerCompletedNCT00325598Phase 1, Phase 2
3Trial Comparing Prone and Supine Intensity-modulated Radiotherapy (IMRT) After Breast-conserving Surgery in Patients With Large Breast Volume at High Risk for Skin Toxicity and FibrosisUnknown statusNCT00887523
4Radiation Therapy Followed by Surgery in Treating Patients With Early-Stage Breast CancerCompletedNCT01024582
5Partial Breast Irradiation (PBI) for Selected Patients With Early Invasive or Non-Invasive Breast CancerActive, not recruitingNCT00694577

Search NIH Clinical Center for Fibrosclerosis of Breast

Genetic Tests for Fibrosclerosis of Breast

About this section

Anatomical Context for Fibrosclerosis of Breast

About this section

MalaCards organs/tissues related to Fibrosclerosis of Breast:

36
Breast

Publications for Fibrosclerosis of Breast

About this section

Variations for Fibrosclerosis of Breast

About this section

Expression for genes affiliated with Fibrosclerosis of Breast

About this section
Search GEO for disease gene expression data for Fibrosclerosis of Breast.

Pathways for genes affiliated with Fibrosclerosis of Breast

About this section

GO Terms for genes affiliated with Fibrosclerosis of Breast

About this section

Biological processes related to Fibrosclerosis of Breast according to GeneCards Suite gene sharing:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1BMP signaling pathwayGO:003050910.2ENG, TGFB1
2cellular response to mechanical stimulusGO:007126010.2ENG, TGFB1
3negative regulation of gene expressionGO:001062910.2ENG, TGFB1
4positive regulation of collagen biosynthetic processGO:003296710.2ENG, TGFB1
5positive regulation of pathway-restricted SMAD protein phosphorylationGO:001086210.2ENG, TGFB1
6positive regulation of protein phosphorylationGO:000193410.1ENG, TGFB1
7regulation of transforming growth factor beta receptor signaling pathwayGO:001701510.1ENG, TGFB1
8response to hypoxiaGO:000166610.1TGFB1, XRCC1
9response to organic substanceGO:001003310.0TGFB1, XRCC1
10positive regulation of NF-kappaB transcription factor activityGO:00510929.9NPM1, TGFB1
11response to drugGO:00424939.6ENG, TGFB1, XRCC1
12vasculogenesisGO:00015709.4ENG, TGFB1
13positive regulation of transcription, DNA-templatedGO:00458939.2NPM1, SRY, TGFB1

Molecular functions related to Fibrosclerosis of Breast according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1type I transforming growth factor beta receptor bindingGO:00347139.6ENG, TGFB1
2type II transforming growth factor beta receptor bindingGO:00051149.4ENG, TGFB1
3protein homodimerization activityGO:00428038.9ENG, NPM1, TGFB1

Sources for Fibrosclerosis of Breast

About this section
2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet