MCID: FBR016
MIFTS: 23

Fibrosclerosis of Breast malady

Categories: Reproductive diseases, Cancer diseases

Aliases & Classifications for Fibrosclerosis of Breast

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Aliases & Descriptions for Fibrosclerosis of Breast:

Name: Fibrosclerosis of Breast 11 13
 
Fibrosis of the Breast 11

Classifications:



External Ids:

Disease Ontology11 DOID:10353
ICD1028 N60.3
SNOMED-CT60 29070004
ICD9CM30 610.3
NCIt43 C3660

Summaries for Fibrosclerosis of Breast

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Wikipedia:69 Fibrosclerosis of the breast is most frequently used to mean sclerosing lobular adenosis of the breast.... more...

MalaCards based summary: Fibrosclerosis of Breast, also known as fibrosis of the breast, is related to multiple epiphyseal dysplasia and holoprosencephaly. An important gene associated with Fibrosclerosis of Breast is XRCC1 (X-Ray Repair Cross Complementing 1), and among its related pathways are TGF-beta Signaling Pathway (sino) and TGF-beta Receptor Signaling Pathway. Affiliated tissues include breast and skin, and related mouse phenotypes are neoplasm and embryo.

Related Diseases for Fibrosclerosis of Breast

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Diseases related to Fibrosclerosis of Breast via text searches within MalaCards or GeneCards Suite gene sharing:

idRelated DiseaseScoreTop Affiliating Genes
1multiple epiphyseal dysplasia9.7ENG, TGFB1
2holoprosencephaly9.7ENG, TGFB1
3mastitis9.7
4diabetic mastopathy9.7
5glomerulosclerosis, focal segmental, 79.6ENG, TGFB1
6multiple synostoses syndrome9.5SRY, TGFB1
7apocrine adenosis of breast8.5ENG, NPM1, SRY, XRCC1
8eosinophilic meningitis8.1ENG, NPM1, SRY, TGFB1, XRCC1

Graphical network of diseases related to Fibrosclerosis of Breast:



Diseases related to fibrosclerosis of breast

Symptoms for Fibrosclerosis of Breast

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Drugs & Therapeutics for Fibrosclerosis of Breast

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Interventional clinical trials:

idNameStatusNCT IDPhase
1Partial Breast Irradiation (PBI) for Selected Patients With Early Breast CancerActive, not recruitingNCT00325598Phase 1, Phase 2
2Partial Breast Irradiation (PBI) for Selected Patients With Early Invasive or Non-Invasive Breast CancerActive, not recruitingNCT00694577Phase 1
3Radiation Therapy Followed by Surgery in Treating Patients With Early-Stage Breast CancerRecruitingNCT01024582
4Trial Comparing Prone and Supine Intensity-modulated Radiotherapy (IMRT) After Breast-conserving Surgery in Patients With Large Breast Volume at High Risk for Skin Toxicity and FibrosisRecruitingNCT00887523

Search NIH Clinical Center for Fibrosclerosis of Breast

Genetic Tests for Fibrosclerosis of Breast

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Anatomical Context for Fibrosclerosis of Breast

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MalaCards organs/tissues related to Fibrosclerosis of Breast:

34
Breast, Skin

Animal Models for Fibrosclerosis of Breast or affiliated genes

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MGI Mouse Phenotypes related to Fibrosclerosis of Breast:

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idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.4NPM1, TGFB1, XRCC1
2MP:00053808.1ENG, NPM1, TGFB1, XRCC1

Publications for Fibrosclerosis of Breast

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Variations for Fibrosclerosis of Breast

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Expression for genes affiliated with Fibrosclerosis of Breast

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Search GEO for disease gene expression data for Fibrosclerosis of Breast.

Pathways for genes affiliated with Fibrosclerosis of Breast

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GO Terms for genes affiliated with Fibrosclerosis of Breast

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Biological processes related to Fibrosclerosis of Breast according to GeneCards Suite gene sharing:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of collagen biosynthetic processGO:00329679.7ENG, TGFB1
2cellular response to mechanical stimulusGO:00712609.7ENG, TGFB1
3positive regulation of protein phosphorylationGO:00019349.7ENG, TGFB1
4positive regulation of pathway-restricted SMAD protein phosphorylationGO:00108629.7ENG, TGFB1
5response to organic substanceGO:00100339.6TGFB1, XRCC1
6regulation of transforming growth factor beta receptor signaling pathwayGO:00170159.5ENG, TGFB1
7response to hypoxiaGO:00016669.5TGFB1, XRCC1
8negative regulation of gene expressionGO:00106299.5ENG, TGFB1
9positive regulation of NF-kappaB transcription factor activityGO:00510929.4NPM1, TGFB1
10positive regulation of transcription, DNA-templatedGO:00458938.6NPM1, SRY, TGFB1

Molecular functions related to Fibrosclerosis of Breast according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1type I transforming growth factor beta receptor bindingGO:003471310.0ENG, TGFB1
2type II transforming growth factor beta receptor bindingGO:00051149.9ENG, TGFB1
3enzyme bindingGO:00198998.9NPM1, TGFB1, XRCC1
4protein heterodimerization activityGO:00469828.6NPM1, SRY, TGFB1
5protein homodimerization activityGO:00428038.2ENG, NPM1, TGFB1

Sources for Fibrosclerosis of Breast

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet