MCID: FBR016
MIFTS: 24

Fibrosclerosis of Breast malady

Categories: Reproductive diseases, Cancer diseases

Aliases & Classifications for Fibrosclerosis of Breast

Aliases & Descriptions for Fibrosclerosis of Breast:

Name: Fibrosclerosis of Breast 12 14
Fibrosis of the Breast 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10353
ICD10 33 N60.3
ICD9CM 35 610.3
NCIt 47 C3660
SNOMED-CT 64 29070004
UMLS 69 C0156318

Summaries for Fibrosclerosis of Breast

MalaCards based summary : Fibrosclerosis of Breast, also known as fibrosis of the breast, is related to glomerulosclerosis, focal segmental, 7 and respiratory syncytial virus infectious disease. An important gene associated with Fibrosclerosis of Breast is XRCC1 (X-Ray Repair Cross Complementing 1), and among its related pathways/superpathways are Wnt / Hedgehog / Notch and TGF-beta Signaling Pathways. Affiliated tissues include breast, and related phenotype is embryo.

Wikipedia : 71 Fibrosclerosis of the breast is most frequently used to mean sclerosing lobular adenosis of the breast.... more...

Related Diseases for Fibrosclerosis of Breast

Graphical network of the top 20 diseases related to Fibrosclerosis of Breast:



Diseases related to Fibrosclerosis of Breast

Symptoms & Phenotypes for Fibrosclerosis of Breast

MGI Mouse Phenotypes related to Fibrosclerosis of Breast:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 embryo MP:0005380 8.92 ENG NPM1 TGFB1 XRCC1

Drugs & Therapeutics for Fibrosclerosis of Breast

Interventional clinical trials:


id Name Status NCT ID Phase
1 Shandong Cancer Hospital Affiliated to Shandong University Recruiting NCT02958033 Phase 3
2 Partial Breast Irradiation (PBI) for Selected Patients With Early Breast Cancer Completed NCT00325598 Phase 1, Phase 2
3 Trial Comparing Prone and Supine Intensity-modulated Radiotherapy (IMRT) After Breast-conserving Surgery in Patients With Large Breast Volume at High Risk for Skin Toxicity and Fibrosis Unknown status NCT00887523
4 Radiation Therapy Followed by Surgery in Treating Patients With Early-Stage Breast Cancer Completed NCT01024582
5 Partial Breast Irradiation (PBI) for Selected Patients With Early Invasive or Non-Invasive Breast Cancer Active, not recruiting NCT00694577

Search NIH Clinical Center for Fibrosclerosis of Breast

Genetic Tests for Fibrosclerosis of Breast

Anatomical Context for Fibrosclerosis of Breast

MalaCards organs/tissues related to Fibrosclerosis of Breast:

39
Breast

Publications for Fibrosclerosis of Breast

Variations for Fibrosclerosis of Breast

Expression for Fibrosclerosis of Breast

Search GEO for disease gene expression data for Fibrosclerosis of Breast.

Pathways for Fibrosclerosis of Breast

Pathways related to Fibrosclerosis of Breast according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.63 ENG TGFB1
2 11.32 ENG TGFB1
3 11.24 ENG TGFB1
4 11.1 ENG TGFB1
5 10.77 ENG NPM1
6 10.39 ENG TGFB1

GO Terms for Fibrosclerosis of Breast

Biological processes related to Fibrosclerosis of Breast according to GeneCards Suite gene sharing:

(show all 13)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.61 NPM1 SRY TGFB1
2 negative regulation of gene expression GO:0010629 9.52 ENG TGFB1
3 response to hypoxia GO:0001666 9.51 TGFB1 XRCC1
4 positive regulation of protein phosphorylation GO:0001934 9.49 ENG TGFB1
5 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.48 NPM1 TGFB1
6 response to organic substance GO:0010033 9.46 TGFB1 XRCC1
7 BMP signaling pathway GO:0030509 9.4 ENG TGFB1
8 cellular response to mechanical stimulus GO:0071260 9.37 ENG TGFB1
9 response to drug GO:0042493 9.33 ENG TGFB1 XRCC1
10 vasculogenesis GO:0001570 9.32 ENG TGFB1
11 positive regulation of pathway-restricted SMAD protein phosphorylation GO:0010862 9.26 ENG TGFB1
12 positive regulation of collagen biosynthetic process GO:0032967 8.96 ENG TGFB1
13 regulation of transforming growth factor beta receptor signaling pathway GO:0017015 8.62 ENG TGFB1

Molecular functions related to Fibrosclerosis of Breast according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 protein homodimerization activity GO:0042803 9.33 ENG NPM1 TGFB1
2 type I transforming growth factor beta receptor binding GO:0034713 8.96 ENG TGFB1
3 type II transforming growth factor beta receptor binding GO:0005114 8.62 ENG TGFB1

Sources for Fibrosclerosis of Breast

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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