Fibrosis malady

Wikipedia: Fibrosis is the formation of excess fibrous connective tissue in an organ or tissue in a reparative or...⁴⁴ more...

MalaCards: Fibrosis is related to carcinoma and cystic fibrosis. An important gene associated with Fibrosis is CFTR (cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)), and among its related pathways are eNOS Signaling and ERK Signaling. The drug potassium para-aminobenzoate and the compounds estrogen and copper have been mentioned in the context of this disorder. Affiliated tissues include brain, skin and liver, and related mouse phenotypes are mortality/aging and digestive/alimentary.

fibrosis 7 43

Diseases related to fibrosis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 1038)

id	Related Disease	Score	Top Affiliating Genes
1	carcinoma	197.5	PIK3CA, PIAS3, PIK3CG, PIN1, PI3, KL
2	cystic fibrosis	190.3	PIK3CG, PI3, PDE3A, PDE4A, RECK, REG1A
3	pancreatitis	165.2	PIK3CA, PIK3CG, PIN1, PI3, LRG1, KL
4	neuronitis	153.9	PIK3CA, PIK3CG, PIN1, KLF6, NCF2, PDE3A
5	leukemia	152.1	PIK3CA, PIK3CG, PIN1, KLF6, NCF2, NCOA3
6	prostatitis	151.6	PIK3CA, PIAS3, PIK3CG, PIN1, WDR19, KL
7	adenocarcinoma	146.5	PIK3CA, PIK3CG, PIN1, WDR19, LRG1, KLF6
8	melanoma	129.1	PIK3CA, PIK3CG, PI3, KL, KLF6, NCOA3
9	hepatocellular carcinoma	128.6	PIK3CA, PIK3CG, PIN1, KL, KLF6, NCOA3
10	thyroiditis	128.6	PIK3CA, PIK3CG, PIN1, NCOA3, PDE4A, RECK
11	rheumatoid arthritis	124.5	PIK3CG, PIN1, KL, PDE4A, RECK, RELA
12	pulmonary fibrosis	117.5	NCF1, NCF2, RETNLB, VWF, VTN, SFTPA1
13	gastric cancer	117.4	PIK3CA, PIK3CG, PIN1, KLF6, NCOA3, RECK
14	hypertension	117.4	PIK3CG, LRG1, KL, KLF6, PDE3A, PDE4A
15	hypoxia	116.3	PIK3CA, PIK3CG, RGCC, PDE4A, RECK, RELA
16	cholesterol	116.1	PIK3CA, PIK3CG, KL, NCF2, NCOA3, RECK
17	atherosclerosis	115.2	PIK3CG, PI3, KL, NCF1, NCF2, PDE4A
18	esophagitis	110.7	PIK3CA, PIK3CG, PIN1, KLF6, NCOA3, PDE4A
19	cervicitis	109.3	PIK3CA, PIK3CG, PIN1, KL, PDE4A, RECK
20	alzheimer's disease	108.9	PIK3CA, PIK3CG, PIN1, KLF6, NCF2, PDE4A
21	diabetes mellitus	108.6	PIK3CA, PIK3CG, PI3, PDE4A, RECK, REG1A
22	retinitis	106.1	PIK3CA, PIK3CG, KLF6, PDE4A, SGK1, CNR1
23	colon cancer	106.1	PIK3CA, PIK3CG, KLF6, RGCC, PDE4A, RECK
24	pneumonia	105.8	PI3, KL, PDE4A, RELA, VTN, SFTPA1
25	tuberculosis	103.7	PIK3CG, NCF1, RELA, WASL, SFTPA1, SFTPA2
26	obesity	101.6	PIK3CA, PIK3CG, NCOA3, RECK, REG3A, RELA
27	breast carcinoma	101.2	PIK3CA, PIK3CG, PI3, NCOA3, RECK, CNR2
28	nephropathy	100.4	LRG1, REG1A, RELA, REN, RETN, SGK1
29	peritonitis	99.2	LRG1, REG1A, RELA, REN, SGK1, KIT
30	pulmonary disease	98.9	PIK3CG, PIN1, PI3, NCF2, NCOA3, PDE4A
31	ischemia	97.6	PIK3CA, PIK3CG, PDE4A, RELA, REN, RETN
32	inflammatory bowel disease	96.0	PDE4A, REG3A, RELA, RETN, RETNLB, KIT
33	lupus erythematosus	93.3	PIK3CG, NCF2, RECK, RETN, VWF, VTN
34	myocardial infarction	93.1	PIK3CG, PI3, PDE4A, RECK, REN, RETN
35	myeloid leukemia	86.4	PIK3CA, PIK3CG, PIN1, KLF6, NCOA3, RECK
36	insulin resistance	84.4	PIK3CA, PIK3CG, RELA, REN, RETN, RETNLB
37	gonococcal synovitis	82.9	PIK3CA, PIK3CG, PI3, PDE4A, RECK, REG1A
38	lung carcinoma	78.3	PIK3CA, PIK3CG, KLF6, RECK, SFTPB, SFTPD
39	dermatitis	78.1	PI3, PDE4A, RELA, CNR1, KITLG, SFTPD
40	blindness	76.3	PIK3CG, PDE4A, REN, CNR1, VWF, RBP4
41	influenza	74.7	PIK3CA, PIK3CG, RECK, RELA, VTN, SFTPA1
42	sarcoidosis	72.3	VTN, SFTPD, SELE, SELL, SELP, SERPINA3
43	ovarian cancer	72.0	PIK3CA, PIK3CG, KLF6, RGCC, NCF1, NCOA3
44	glomerulonephritis	71.9	REN, SGK1, KIT, KITLG, VWF, VTN
45	cerebritis	71.8	PIK3CG, KLF6, NCF1, PDE4A, REG1A, RELA
46	copd	71.2	PDE4A, RELA, VWF, SFTPB, SFTPD, GCLC
47	lung adenocarcinoma	69.3	PIK3CA, PIK3CG, LRG1, KLF6, VWF, SFTPB
48	rhinitis	66.8	PIK3CG, PDE4A, RELA, RETN, KITLG, SFTPA1
49	neuropathy	65.6	PDE4A, REN, RETN, CNR1, VWF, BTD
50	hyperglycemia	65.4	PIK3CA, PIK3CG, RETN, SGK1, CNR1, VWF

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 potassium para-aminobenzoate

MalaCards organs/tissues related to fibrosis:

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MGI Mouse Phenotypes related to fibrosis:

²⁵ (show all 29)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	mortality/aging	MP:0010768	INF	PIK3CA, , KL, KLF6, RECK, RELA
2	digestive/alimentary phenotype	MP:0005381	INF	, KL, NCOA3, RETNLB, WASL, KIT
3	pigmentation phenotype	MP:0001186	INF	KIT, KITLG, BTD, SERPINC1, NAGLU, BRCA1
4	limbs/digits/tail phenotype	MP:0005371	INF	, KL, RECK, RELA, KIT, KITLG
5	integument phenotype	MP:0010771	INF	PIK3CG, PIN1, KL, KLF6, NCOA3, RECK
6	respiratory system phenotype	MP:0005388	INF	KL, SFRP4, SFTPC, SFTPD, SELL, SELP
7	hematopoietic system phenotype	MP:0005397	INF	KLF6, KIT, PCNA, SERPINB1, BRCA1, VHL
8	endocrine/exocrine gland phenotype	MP:0005379	18.8	KL, REG1A, WASL, SEC61A1, SELL, SERPINE2
9	craniofacial phenotype	MP:0005382	INF	, NCOA3, KIT, KITLG, NAGLU, MYO6
10	liver/biliary system phenotype	MP:0005370	INF	KLF6, NCOA3, RECK, RETN, KIT, GCLC
11	nervous system phenotype	MP:0003631	INF	, KL, PDE4A, RECK, RELA, REN
12	behavior/neurological phenotype	MP:0005386	INF	PIK3CA, KL, NCOA3, REN, CNR1, KIT
13	reproductive system phenotype	MP:0005389	INF	PIK3CA, KLF6, NCOA3, PDE3A, REG1A, REN
14	vision/eye phenotype	MP:0005391	INF	PIK3CA, PIN1, , RELA, KIT, KITLG
15	skeleton phenotype	MP:0005390	INF	PIK3CG, , RECK, RELA, CNR1, KIT
16	growth/size phenotype	MP:0005378	INF	PIK3CA, PIK3CG, PIN1, KL, KLF6, NCOA3
17	muscle phenotype	MP:0005369	INF	PIK3CA, PIK3CG, , KL, NCOA3, RELA
18	embryogenesis phenotype	MP:0005380	INF	PIK3CA, , KLF6, NCOA3, RECK, WASL
19	hearing/vestibular/ear phenotype	MP:0005377	INF	, NCOA3, KIT, KITLG, NAGLU, VDR
20	normal phenotype	MP:0002873	INF	PDE3A, RELA, REN, WASL, VTN, GCLC
21	cardiovascular system phenotype	MP:0005385	INF	PIK3CA, PIK3CG, KL, KLF6, PDE4A, RECK
22	tumorigenesis	MP:0002006	INF	PIK3CA, NCOA3, KIT, KITLG, SFTPC, SELL
23	immune system phenotype	MP:0005387	INF	KL, NCOA3, PDE4A, REN, RETNLB, CNR2
24	no phenotypic analysis	MP:0003012	INF	SGK1, CNR1, SFTPC, PCNA, SERPINE2, VEGFA
25	cellular phenotype	MP:0005384	INF	PIK3CA, PIK3CG, PIN1, , KL, KLF6
26	adipose tissue phenotype	MP:0005375	INF	PIK3CA, KL, NCOA3, RETN, CNR1, SEC61A1
27	homeostasis/metabolism phenotype	MP:0005376	INF	PIK3CA, PIK3CG, KL, NCOA3, REG1A, REG3A
28	other phenotype	MP:0005395	INF	KL, RECK, CNR1, SERPINH1, RARA, BLOC1S6
29	renal/urinary system phenotype	MP:0005367	INF	KL, NCOA3, REN, SGK1, KIT, SFRP4

Articles related to fibrosis:

(show top 50)    (show all 3770)

id	Title	Authors	Year	Affiliating Genes
1	An association study on contrasting cystic fibrosis e ndophenotypes recognizes KRT8 but not KRT18 as a modifier of cystic fibrosis di sease severity and CFTR mediated residual chloride secretion. (21548936)	Stanke F.... TA1mmler B.	2011	KRT18, KRT8
2	Scraping fibrosis: UMODulating renal fibrosis. (21546974)	Eddy A.A.	2011	UMOD
3	Transient receptor potential canonical channel 6 link s Ca2+ mishandling to cystic fibrosis transmembrane conductance regulator chann el dysfunction in cystic fibrosis. (20203293)	Antigny F.... Vandebrouck C.	2011	CFTR, TRPC6
4	The cystic fibrosis-causing mutation deltaF508 affect s multiple steps in cystic fibrosis transmembrane conductance regulator biogene sis. (20667826)	Thibodeau P.H.... Thomas P.J.	2010	CFTR
5	Lack of correlation between pulmonary disease and cys tic fibrosis transmembrane conductance regulator dysfunction in cystic fibrosis : a case report. (20420703)	Levy H.... Colin A.A.	2010	CFTR
6	Cystic fibrosis transmembrane conductance regulator m utation spectrum in patients with cystic fibrosis in Tunisia. (19715466)	Fredj S.H.... Claustres M.	2009	CFTR
7	Insulin therapy to improve BMI in cystic fibrosis-rel ated diabetes without fasting hyperglycemia: results of the cystic fibrosis rel ated diabetes therapy trial. (19592632)	Moran A.... Allen H.	2009	INS
8	Unique mutations of the cystic fibrosis transmembrane conductance regulator gene of three cases of cystic fibrosis in Nagasaki, Japa n. (19652440)	Izumikawa K.... Kohno S.	2009	CFTR
9	Serum fibrosis marker levels decrease after successfu l antiviral treatment in chronic hepatitis C patients with advanced fibrosis. (19068241)	Fontana R.J.... Su G.L.	2009	MMP1
10	Hepatitis C virus therapy in liver transplant recipie nts: response predictors, effect on fibrosis progression, and importance of the initial stage of fibrosis. (19025933)	Roche B.... Samuel D.	2008	IFNA1
11	Relationship of serum fibrosis markers with liver fibrosis stage and collagen content in patients with advanced chronic hepatitis C. (18175357)	Fontana R.J.... Wright E.C.	2008	MMP1, TIMP1
12	Serum adiponectin is increased in advancing liver fibrosis and declines with reduction in fibrosis in chronic hepatitis B. (17462782)	Hui C.K.... Lau G.K.	2007	ADIPOQ
13	Topical cystic fibrosis transmembrane conductance regulator gene replacement for cystic fibrosis-related lung disease. (17443603)	Lee T.... Southern K.W.	2007	CFTR
14	Pravastatin Inhibits the Rho/CCN2/extracellular matrix cascade in human fibrosis explants and improves radiation-induced intestinal fibrosis in rats. (17875761)	Haydont V.... Vozenin-Brotons M.C.	2007	CTGF, RHOD
15	The NAFLD fibrosis score: a noninvasive system that identifies liver fibrosis in patients with NAFLD. (17393509)	Angulo P.... Day C.P.	2007	ALB
16	Differential sensitivity of the cystic fibrosis (CF)-associated mutants G551D and G1349D to potentiators of the cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channel. (16311240)	Cai Z.... Sheppard D.N.	2006	CFTR
17	Progression of fibrosis in hepatitis C with and without schistosomiasis: correlation with serum markers of fibrosis. (16557547)	Kamal S.M.... Afdhal N.H.	2006	BMP6
18	Patients with cystic fibrosis managed at the cystic fibrosis units of Madrid: cross-sectional study of 387 subjects (15171831)	Garcia Hernandez G.... Prados C.	2004	CFTR
19	Free secretory component from cystic fibrosis sputa d isplays the cystic fibrosis glycosylation phenotype. (14597481)	Marshall L.J.... Shute J.K.	2004	IL8
20	Cystic fibrosis transmembrane conductance regulator (CFTR)-mediated residual chloride secretion does not protect against early chronic Pseudomonas aeruginosa infection in F508del homozygous cystic fibrosis patients. (14605249)	Derichs N.... Ballmann M.	2004	CFTR
21	Cytokine regulation of periportal fibrosis in humans infected with Schistosoma mansoni: IFN-gamma is associated with protection against fibrosis and TNF-alpha with aggravation of disease. (12097398)	Henri S.... Dessein A.J.	2002	TNF, IFNG
22	Tyrosine kinase c-Src constitutes a bridge between cystic fibrosis transmembrane regulator channel failure and MUC1 overexpression in cystic fibrosis. (11872746)	Gonzalez-Guerrico A.M.... Santa-Coloma T.A.	2002	SRC, CFTR, MUC1
23	Differences in the fibrogenic response after transfer of active transforming growth factor-beta1 gene to lungs of 'fibrosis-prone' and 'fibrosis-resistant' mouse strains. (12151305)	Kolb M.... Gauldie J.	2002	TGFB1
24	Identification of mutation in the gene cystic fibrosis transmembrane regulator (CFTR) in Chilean patients with cystic fibrosis (11680956)	Repetto G.... Foradori A.	2001	CFTR
25	Identification of novel mutations in Arabs with cystic fibrosis and their impact on the cystic fibrosis transmembrane regulator mutation detection rate in Arab populations. (10834512)	Kambouris M.... Meyer B.F.	2000	CFTR
26	Cystic fibrosis transmembrane conductance regulator does not affect neutrophil migration across cystic fibrosis airway epithelial monolayers. (10751364)	Pizurki L.... Suter S.	2000	CFTR
27	Autocrine overexpression of CTGF maintains fibrosis: RDA analysis of fibrosis genes in systemic sclerosis. (10942593)	Shi-wen X.... Abraham D.J.	2000	CTGF
28	Expression of cystic fibrosis transmembrane conductance regulator in liver tissue from patients with cystic fibrosis. (10915740)	Kinnman N.... Hultcrantz R.	2000	CFTR
29	Restoration of bacterial killing activity of human respiratory cystic fibrosis cells through cationic vector-mediated cystic fibrosis transmembrane conductance regulator gene transfer. (10466626)	Biffi A.... Conese M.	1999	CFTR
30	Abnormal expression of the cystic fibrosis transmembrane regulator in chronic sinusitis in cystic fibrosis and non-cystic fibrosis patients. (10378526)	Coltrera M.D.... Gown A.M.	1999	CFTR
31	Expression of delta F508 cystic fibrosis transmembrane conductance regulator protein and related chloride transport properties in the gallbladder epithelium from cystic fibrosis patients. (10347100)	Dray-Charier N.... Housset C.	1999	CFTR
32	Role and interaction of connective tissue growth factor with transforming growth factor-beta in persistent fibrosis: A mouse fibrosis model. (10457363)	Mori T.... Takehara K.	1999	TGFB1, TGFB3, TGFB2
33	Recombinant DNase in cystic fibrosis: a protocol for targeted introduction through n-of-1 trials. Scottish Cystic Fibrosis Group. (10836333)	BAPllert F.G.... Innes J.A.	1999	APEX1
34	The ROMK-cystic fibrosis transmembrane conductance re gulator connection: new insights into the relationship between ROMK and cystic fibrosis transmembrane conductance regulator channels. (9442363)	Ho K.	1998	KCNJ1
35	A mutation in the cystic fibrosis transmembrane conductance regulator gene associated with elevated sweat chloride concentrations in the absence of cystic fibrosis. (9499426)	Mickle J.E.... Cutting G.R.	1998	CFTR
36	Detection of five novel mutations of the cystic fibrosis transmembrane regulator (CFTR) gene in Pakistani patients with cystic fibrosis: Y569D, Q98X, 296+12(T>C), 1161delC and 621+2(T>C). (9482579)	Malone G.... Super M.	1998	CFTR
37	Cystic-fibrosis-like disease unrelated to the cystic fibrosis transmembrane conductance regulator. (9654209)	Mekus F.... Veeze H.J.	1998	CFTR
38	Identification of common cystic fibrosis mutations in African-Americans with cystic fibrosis increases the detection rate to 75%. (9150159)	Macek M.... Cutting G.R.	1997	CFTR
39	Repeat administration of an adenovirus vector encodin g cystic fibrosis transmembrane conductance regulator to the nasal epithelium o f patients with cystic fibrosis. (8617884)	Zabner J.... Standaert T.A.	1996	CFTR
40	Cytokines in human renal interstitial fibrosis. I. Interleukin-1 is a paracrine growth factor for cultured fibrosis-derived kidney fibroblasts. (7752582)	Lonnemann G.... Dinarello C.A.	1995	IL1B
41	Neonatal screening for cystic fibrosis: result of a pilot study using both immunoreactive trypsinogen and cystic fibrosis gene mutation analyses. (8530001)	FAcrec C.... Roussey M.	1995	CFTR
42	Identification of the M1101K mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene and complete detection of cystic fibrosis mutations in the Hutterite population. (7680525)	Zielenski J.... Morgan K.	1993	CFTR
43	Mutations and sequence variations detected in the cystic fibrosis transmembrane conductance regulator (CFTR) gene: a report from the Cystic Fibrosis Genetic Analysis Consortium. (1284534)	Tsui L.-C.	1992	CFTR
44	Extensive posttranscriptional deletion of the coding sequences for part of nucleotide-binding fold 1 in respiratory epithelial mRNA transcripts of the cystic fibrosis transmembrane conductance regulator gene is not associated with the clinical manifestations of cystic fibrosis. (1381723)	Chu C.S.... Crystal R.G.	1992	CFTR
45	Cystic fibrosis transmembrane conductance regulator and the etiology and pathogenesis of cystic fibrosis. (1378801)	McIntosh I.... Cutting G.R.	1992	CFTR
46	Abnormal localization of cystic fibrosis transmembrane conductance regulator in primary cultures of cystic fibrosis airway epithelia. (1379244)	Denning G.M.... Welsh M.J.	1992	RECK
47	Expression of the cystic fibrosis transmembrane conductance regulator gene in the respiratory tract of normal individuals and individuals with cystic fibrosis. (1713683)	Trapnell B.C.... Crystal R.G.	1991	CFTR
48	Cystic fibrosis with three mutations in the cystic fibrosis transmembrane conductance regulator gene. (1715308)	DAPrk T.... TA1mmler B.	1991	CFTR
49	Sequence analysis of the cystic fibrosis gene in patients with disseminated bronchiectatic lung disease. Application in the identification of a cystic fibrosis patient with atypical clinical course. (1749205)	Poller W.... MA1ller K.M.	1991	CFTR
50	Increased expression of the interleukin-8 gene by alveolar macrophages in idiopathic pulmonary fibrosis. A potential mechanism for the recruitment and activation of neutrophils in lung fibrosis. (1752942)	CarrAc P.C.... Riches D.W.	1991	IL8

Genes related to fibrosis according to GeneCards:

(show top 50)    (show all 1188)

id	Symbol	Description	Score	GeneCards Section Context
1	CFTR	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)	11.1	Publications, Summaries, Databases, Aliases & Descriptions (show all 6 sections) Domains & Families, Orthologs
2	KIF21A	kinesin family member 21A	11.1	Publications, Aliases & Descriptions, Summaries
3	PHOX2A	paired-like homeobox 2a	11.1	Publications, Aliases & Descriptions, Summaries
4	S100A8	S100 calcium binding protein A8	11.1	Publications, Aliases & Descriptions, Summaries
5	FEOM3	fibrosis of extraocular muscles, congenital, 3	11.0	Publications, Aliases & Descriptions
6	SFTPA1	surfactant protein A1	11.0	Publications, Summaries
7	TUBB3	tubulin, beta 3 class III	11.0	Publications, Summaries
8	SFTPA2	surfactant protein A2	11.0	Publications, Summaries
9	S100A9	S100 calcium binding protein A9	11.0	Publications, Summaries
10	ATF6	activating transcription factor 6	11.0	Publications, Summaries
11	CFM1	cystic fibrosis modifier 1	11.0	Publications, Aliases & Descriptions, Orthologs
12	SLC9A3R1	solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1	11.0	Publications, Summaries
13	ELMOD2	ELMO/CED-12 domain containing 2	11.0	Publications, Summaries
14	DEFB1	defensin, beta 1	11.0	Publications, Summaries
15	DERL1	derlin 1	11.0	Publications, Summaries
16	DNASE1	deoxyribonuclease I	11.0	Publications, UniProt Related, Summaries
17	SLC9A3R2	solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2	11.0	Publications, Summaries
18	DNAJC5	DnaJ (Hsp40) homolog, subfamily C, member 5	11.0	Publications, Summaries
19	IFRD1	interferon-related developmental regulator 1	11.0	Publications, Summaries
20	C5	complement component 5	11.0	Publications, Summaries
21	CLCA2	chloride channel accessory 2	11.0	Publications, Summaries
22	CFM2	cystic fibrosis modifier 2	11.0	Aliases & Descriptions
23	SM2	Hepatic fibrosis susceptibility due to Schistosoma mansoni infection	11.0	Aliases & Descriptions
24	CFTRP1	cystic fibrosis transmembrane conductance regulator pseudogene 1	11.0	Aliases & Descriptions
25	CIRH1A	cirrhosis, autosomal recessive 1A (cirhin)	11.0	Summaries
26	HFE2	hemochromatosis type 2 (juvenile)	11.0	Summaries
27	NOV	nephroblastoma overexpressed	11.0	Publications, Summaries
28	ITGA1	integrin, alpha 1	11.0	Summaries
29	TGFB1	transforming growth factor, beta 1	11.0	Publications
30	TIMP1	TIMP metallopeptidase inhibitor 1	11.0	Publications
31	CD36	CD36 molecule (thrombospondin receptor)	11.0	Publications
32	CTGF	connective tissue growth factor	11.0	Publications
33	BMP6	bone morphogenetic protein 6	11.0	Publications
34	ELANE	elastase, neutrophil expressed	11.0	Publications
35	TERC	telomerase RNA component	11.0	Publications
36	HGF	hepatocyte growth factor (hepapoietin A; scatter factor)	11.0	Publications
37	IL8	interleukin 8	11.0	Publications
38	MMP1	matrix metallopeptidase 1 (interstitial collagenase)	11.0	Publications
39	TERT	telomerase reverse transcriptase	11.0	Publications
40	PDZD3	PDZ domain containing 3	11.0	Summaries
41	INPP5E	inositol polyphosphate-5-phosphatase, 72 kDa	11.0	Summaries
42	SFTPC	surfactant protein C	11.0	Publications
43	MPO	myeloperoxidase	11.0	Publications
44	CCL2	chemokine (C-C motif) ligand 2	11.0	Publications
45	IL13	interleukin 13	11.0	Publications
46	SMAD3	SMAD family member 3	11.0	Publications
47	HMOX1	heme oxygenase (decycling) 1	11.0	Publications
48	IL1B	interleukin 1, beta	11.0	Publications
49	SFTPD	surfactant protein D	11.0	Publications
50	CCL17	chemokine (C-C motif) ligand 17	11.0	Publications

Pathways related to fibrosis according to GeneDecks:

(show top 50)    (show all 175)

id	Pathway	Score	Top Affiliating Genes
1	eNOS Signaling36	INF	KIT, KITLG, LMTK2, BMP1, BMP2, BMP3
2	ERK Signaling36	INF	KIT, KITLG, VEGFC, LMTK2, MYC, BMP1
3	Paxillin Interactions36	INF	KIT, KITLG, VEGFC, LMTK2, BMP1, BMP2
4	Angiogenesis3	INF	RECK, REN, VHL, VEGFC, KDR, ITGAV
5	Rac1 Pathway36	INF	NCF2, KITLG, BMP1, BMP3, BMP4, BMP6
6	Integrin Pathway36	INF	MYC, RAF1, LAMA3, LAMC2, JUN, ITGA1
7	MIF Mediated Glucocorticoid Regulation36	20.7	BMP1, BMP2, BMP3, BMP4, BMP6, BMP7
8	Endothelin-1 Signaling Pathway36	20.1	KIT, LMTK2, MYC, BMP1, BMP2, BMP3
9	all-trans-Retinoic Acid Signaling in Brain36	19.9	BMP1, BMP2, BMP3, BMP4, BMP6, BMP7
10	Chagas disease (American trypanosomiasis)20	18.5	PIK3CA, PIK3CG, RELA, SERPINE1, CHUK, CFLAR
11	IL-6 Pathway36	18.4	PIAS3, BMP1, BMP2, BMP3, BMP4, BMP6
12	PGC1Alpha Pathway36	17.0	BMP1, BMP2, BMP3, BMP4, BMP6, BMP7
13	Immune System38	17.0	SEC61A1, SEC61B, VCAM1, BLMH, LGALS3, MX1
14	Measles20	15.4	PIK3CA, PIK3CG, RELA, CHUK, MX1, MSN
15	Jak-STAT signaling pathway20	15.4	PIK3CA, PIAS3, PIK3CG, MYC, LIFR, BCL2L1
16	eIF2 Pathway36	15.3	KIT, KITLG, VEGFC, BMP1, BMP3, BMP4
17	NFAT Signaling and Lymphocyte Interactions36	14.9	BMP1, BMP2, BMP3, BMP4, BMP6, BMP7
18	Amoebiasis20	14.8	PIK3CA, RELA, SERPINB3, SERPINB1, RAB5A, MUC2
19	Metalloproteases in connective tissue degradation10	14.6	CMA1, LAMA3, LAMC2, CDH1, MMP1, MMP10
20	Actin-Based Motility by Rho Family GTPases36	14.3	WASL, BMP1, BMP3, BMP4, BMP7, UTS2
21	NOD-like receptor signaling pathway20	14.1	RELA, CHUK, IL18, IL1B, IL6, IL8
22	Th17 Differentiation37	14.1	JAK2, CD28, CD4, CD80, IL12B, IL17A
23	Inhibition of Matrix Metalloproteinases36	14.1	RECK, MMP1, MMP10, MMP11, MMP12, MMP13
24	Immune response MIF-mediated glucocorticoid regulation10	13.7	RELA, VCAM1, CHUK, JUN, MMP1, FOS
25	PKR Pathway36	13.4	RELA, CHUK, ATF2, JUN, FOS, MAPK8
26	Immune response_IFN gamma signaling pathway41	13.2	PIK3CA, BRCA1, MYC, CEBPB, ATF2, JAK2
27	Th1 Differentiation37	13.2	JUN, JAK2, CD28, CD4, CD80, FOS
28	Immune response_Bacterial infections in normal airways41	13.1	RELA, CHUK, LBP, CFTR, CD14, IL1B
29	Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response10	12.8	CHUK, LBP, JUN, CD14, IL11, IL6
30	Bacterial infections in CF airways41	12.7	RELA, SFTPA1, SFTPD, CHUK, MUC1, LBP
31	EGF Pathway36	12.3	MYC, RAF1, RAB5A, CHUK, MUC1, JUN
32	Immune response IFN gamma signaling pathway10	12.2	ATF2, JAK2, IFNG, IFNGR2, CALM1, CAMK2G
33	Development Prolactin receptor signaling10	11.6	PIK3CA, RELA, MYC, RAF1, BCL2, BCL2L1
34	Tuberculosis20	INF	RELA, VDR, RAF1, RAB5A, BCL2, BAX
35	Toxoplasmosis20	INF	PIK3CA, PIK3CG, RELA, BCL2, BCL2L1, CHUK
36	p53 Mediated Apoptosis36	INF	KIT, KITLG, VEGFC, BMP1, BMP2, BMP3
37	Cytokine-cytokine receptor interaction20	INF	KIT, KITLG, VEGFA, VEGFC, BMP2, BMP7
38	p70S6K Signaling36	INF	KIT, KITLG, VEGFC, BMP1, BMP2, BMP3
39	Cell adhesion_ECM remodeling41	INF	VTN, SERPINE2, SERPINE1, VCAN, LAMA3, LAMC2
40	MAPK signaling pathway20	INF	RELA, MYC, RAF1, CHUK, ATF4, ATF2
41	Pancreatic Adenocarcinoma36	INF	KIT, KITLG, VEGFC, LMTK2, BMP1, BMP2
42	Pertussis20	INF	RELA, SFTPA1, JUN, CD14, ITGAM,
43	Endocytosis20	INF	KIT, RAB11B, RAB5A, RAB11A, KDR, FLT1
44	Cell adhesion ECM remodeling10	INF	VTN, SERPINE2, SERPINE1, VCAN, LAMA3, LAMC2
45	Antioxidant Action of Vitamin-C36	INF	NCF1, NCF2, KIT, KITLG, VEGFC, MYO6
46	Development VEGF signaling and activation10	INF	PIK3CA, RELA, SELE, VCAM1, RAF1, KDR
47	Estrogen Pathway36	INF	NCOA3, KIT, KITLG, BRCA1, VEGFC, LMTK2
48	SOCS Pathway36	INF	VEGFC, BMP1, BMP2, BMP3, BMP4, BMP6
49	Phagosome20	INF	NCF1, NCF2, SFTPA1, SFTPD, SEC61A1, SEC61B
50	P2Y Receptor Signaling36	INF	KIT, VEGFC, LMTK2, MYC, RAF1, LIFR

Compounds related to fibrosis according to GeneDecks:

(show top 50)    (show all 523)

id	Compound	Score	Top Affiliating Genes
1	estrogen32	INF	KLF6, NCOA3, RETN, VWF, PCNA, GC
2	copper32 18	INF	SFTPB, RBP4, SERPINA1, NAGLU, LPA, LIF
3	heparan sulfate32 18	INF	VTN, GC, SERPINC1, SERPINF2, SERPINE1, VIM
4	phospholipid32	INF	PDE4A, VWF, SFTPB, SFTPC, SFTPD, RBP4
5	adenylate32	INF	PIK3CA, PIK3CG, KLF6, PDE3A, PDE4A, SGK1
6	iron32 18	INF	RECK, KITLG, RBP4, SETD2, SERPINA1, SERPINA3
7	glutamate32	INF	PIK3CA, SGK1, CNR1, CNR2, VTN, PCNA
8	arginine32	INF	PIK3CA, NCOA3, PDE4A, RECK, REN, SGK1
9	pentoxifylline32 9 9	20.6	PDE4A, SELL, SELP, NAGLU, VCAM1, BMP2
10	15-deoxy-delta-12,14-prostaglandin j232	17.2	PIK3CG, SERPINE1, VEGFA, VCAM1, MYC, BMP6
11	methacholine32 9 9	18.8	REN, VIP, MPO, CD79A, CD14, CDKN3
12	ag 147832	16.6	PIK3CA, PIK3CG, SERPINE1, RAF1, MUC5AC, JUN
13	doxycycline32 9 9	18.6	SFTPB, SFTPC, SCGB1A1, LACTB, CD79A, CDK2
14	mifepristone32 42 9 9	19.1	PI3, SGK1, LIF, BIRC5, ZFP36, BCL2L1
15	phosphatidylserine32 9 9	17.7	RECK, VWF, SELE, VIM, LPL, BCL2
16	pioglitazone32 9 9	17.5	RETN, RBP4, BSG, VEGFA, LPL, VCAM1
17	sialic acid32	15.2	RECK, RBP4, SELL, SERPINF2, SERPINA3, NAGLU
18	pertussis32	15.1	PIK3CG, VIP, P2RY2, JUN, ITGA4, FPR1
19	rottlerin32 42	16.1	PIK3CG, VCAM1, JUN, CD36, CD40LG, CDK1
20	enalapril32 9 9	16.8	REN, SERPINE1, VIP, NAGLU, BMP6, BMP7
21	docetaxel32 34 9 9	17.7	KIT, SETD2, BRCA1, VEGFA, VDR, MYC
22	raloxifene32 9 9	16.2	NCOA3, VWF, SERPINC1, SERPINE1, VDR, BMP2
23	atropine32 9 9	16.1	PCNA, VIP, UTS2, BCHE, SCT, MME
24	fitc32	13.9	VWF, PCNA, SELL, BIRC5, LBP, CD14
25	ciprofloxacin32 9 9	15.8	VIM, VDAC1, LACTB, CEBPB, MMP1, IL18
26	leflunomide32 9 9	15.5	PCNA, MMP1, MMP3, IL13, IL18R1, IL1R1
27	chenodeoxycholic acid32 9 18 9	16.2	VDR, CETP, JUN, APOB, MAPK14, CCND1
28	vincristine32 34 9 9	16.2	RECK, KIT, ATF4, ITGA4, FGF2, ANXA5
29	diisopropylfluorophosphate32	13.2	SERPINC1, SERPINA1, SERPINE1, SERPINA3, LIF, BCHE
30	c-peptide32	13.1	RETN, NAGLU, KCNJ11, SCT, LEP, IL7
31	ivig32	13.1	VWF, SEPSECS, S100A12, IL18R1, IL1RAPL2, IL3
32	lactose32 9 9	14.9	SELE, SELL, LGALS1, LGALS3, LCT, CFTR
33	hirudin32	12.4	SELL, SERPINC1, SERPINF2, SCG5, F9, F5
34	nitroglycerin32 9 9	13.5	ALDH2, TNFRSF11B, SST, ELANE, NPR1
35	nmda32 42	INF	PIK3CA, PDE4A, CNR1, VIM, LNX1, PARK2
36	geldanamycin32 9 9	INF	PIK3CG, SETD2, VEGFA, RAF1, BIRC5, PARK2
37	groalpha32	INF	SELE, VCAM1, MMP13, IL10, IL13, IL17A
38	ly29400232	INF	PIK3CA, PIK3CG, PI3, RETN, SGK1, VTN
39	actinomycin d32	INF	PIK3CA, PIK3CG, PDE4A, RETN, SGK1, KIT
40	triacylglycerol32	INF	RBP4, SERPINE1, LPL, CLPS, SCD, LEP
41	ethanol32 34 9 18 9	INF	KL, KITLG, SFTPC, GCLC, SERPINA1, LPA
42	histamine32 18	INF	PIK3CA, PI3, PDE4A, CNR1, KIT, KITLG
43	fibrinogen32	INF	KLF6, RECK, RETN, VTN, SFTPB, SFTPC
44	serine32	INF	PIK3CA, PIK3CG, PIN1, PI3, KLF6, PDE4A
45	rapamycin32 42	INF	PIK3CG, PIN1, SGK1, KIT, KITLG, SELL
46	capsaicin32	INF	CNR1, SELE, VIP, CMA1, LEP, B3GAT1
47	suramin32 9 9	INF	RECK, PCNA, VIP, VEGFA, BMP6, RAF1
48	chloroquine32 34 9 9	INF	KIT, VTN, SERPINC1, BRCA1, BMP6, RAF1
49	prostacyclin32	INF	PDE4A, REG3A, REN, VWF, VTN, SELE
50	ang ii32	INF	PIK3CG, REN, VEGFA, LAP3, JAK2, CD36

Cellular components related to fibrosis according to GeneDecks:

(show all 18)

id	Name	GO ID	Score	Top Affiliating Genes
1	extracellular region	GO:005576	INF	LRG1, KL, REG1A, RETN, RETNLB, KITLG
2	extracellular space	GO:005615	INF	LRG1, KL, REG3A, REN, KIT, KITLG
3	membrane	GO:016020	INF	PIK3CG, LRG1, PDE4A, RECK, REN, VHL
4	plasma membrane	GO:005886	INF	PIK3CG, KL, RECK, SGK1, CNR1, CNR2
5	extracellular matrix	GO:031012	16.6	VWF, VTN, SERPINE2, SERPINE1, LPL, VCAN
6	basolateral plasma membrane	GO:016323	15.9	BEST1, KCNQ1, UMOD, P2RY1, P2RY2, P2RY4
7	protein complex	GO:043234	14.9	BRCA1, MYC, BMP2, RAB11A, UTRN, S100A1
8	Golgi lumen	GO:005796	14.3	VCAN, SDC1, MUC1, MUC2, MUC3A, MUC3B
9	platelet alpha granule lumen	GO:031093	14.2	VWF, SERPINF2, SERPINA1, SERPINE1, VEGFA, VEGFC
10	membrane raft	GO:045121	INF	SELE, BSG, RAB5A, UMOD, FURIN, JAK2
11	external side of plasma membrane	GO:009897	INF	KIT, VWF, SELL, SELP, SEMA7A, VCAM1
12	integral to plasma membrane	GO:005887	INF	KL, CNR1, CNR2, SELL, SELP, BPI
13	proteinaceous extracellular matrix	GO:005578	INF	PI3, VWF, SERPINA1, VEGFA, VCAN, BMP4
14	apical plasma membrane	GO:016324	INF	VAMP3, CLCA4, SCNN1A, SCNN1B, SCNN1G, UMOD
15	cytoplasm	GO:005737	INF	PIAS3, PIK3CG, PIN1, KLF6, RGCC, NCF2
16	cytosol	GO:005829	INF	PIK3CA, PIK3CG, NCF1, NCF2, PDE3A, PDE4A
17	perinuclear region of cytoplasm	GO:048471	INF	PDE4A, GC, SELE, LMNA, LMTK2, MYO6
18	cell surface	GO:009986	INF	SFRP4, VEGFA, LPL, VCAM1, BMP2, RARA

Biological processes related to fibrosis according to GeneDecks:

(show top 50)    (show all 59)

id	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of transcription from RNA polymerase II promoter	GO:045944	INF	KLF6, NCOA3, RELA, SERPINF2, SERPINE1, BRCA1
2	response to hypoxia	GO:001666	INF	SFTPB, SERPINA1, VEGFA, VCAM1, BMP2, RAF1
3	inflammatory response	GO:006954	INF	PIK3CG, RELA, CNR2, KIT, SELE, SELP
4	positive regulation of angiogenesis	GO:045766	INF	SERPINE1, VEGFA, UTS2, KDR, CHI3L1, CD34
5	response to drug	GO:042493	INF	NCF2, PDE3A, PDE4A, REN, VEGFC, LPL
6	small molecule metabolic process	GO:044281	INF	PIK3CA, PIK3CG, NCOA3, WASL, GCLC, GC
7	signal transduction	GO:007165	INF	PDE4A, KIT, KITLG, VEGFC, VDR, RARA
8	virus-host interaction	GO:019048	INF	RELA, VIM, VDAC1, VCAM1, KDR, BAX
9	positive regulation of cell proliferation	GO:008284	INF	REG1A, KIT, VIP, VEGFA, VEGFC, MYC
10	cell-cell signaling	GO:007267	20.0	BMP2, BMP3, S100A9, XCL1, CEACAM6, FZD1
11	innate immune response	GO:045087	19.9	PIK3CG, PIN1, NCF1, NCF2, RELA, SFTPD
12	positive regulation of transcription, DNA-dependent	GO:045893	18.8	KLF6, NCOA3, RELA, BRCA1, VHL, MYC
13	response to lipopolysaccharide	GO:032496	17.7	NCF2, CNR1, CNR2, SFTPB, SFTPC, SELE
14	aging	GO:007568	17.2	KL, NCF2, CNR1, VDR, VCAM1, P2RY1
15	extracellular matrix organization	GO:030198	16.2	RECK, SERPINH1, BMP1, CMA1, LGALS3, FURIN
16	cytokine-mediated signaling pathway	GO:019221	15.8	PIN1, KLF6, RELA, KIT, VCAM1, LIFR
17	transforming growth factor beta receptor signaling pathway	GO:007179	15.3	SERPINE1, MYC, UBC, MSTN, FURIN, JUN
18	platelet degranulation	GO:002576	15.2	VWF, SELP, SERPINF2, SERPINA1, SERPINE1, VEGFA
19	positive regulation of I-kappaB kinase/NF-kappaB cascade	GO:043123	15.0	RELA, PARK2, LGALS1, LGALS9, CHUK, UBC
20	response to glucocorticoid stimulus	GO:051384	14.7	SFRP4, SFTPB, SFTPC, SERPINE1, BGLAP, BCHE
21	elevation of cytosolic calcium ion concentration	GO:007204	14.5	UTS2, BDKRB1, S1PR3, P2RY1, P2RY2, P2RY4
22	positive regulation of ERK1 and ERK2 cascade	GO:070374	14.5	SEMA7A, SERPINF2, BMP2, BMP4, KDR, CHI3L1
23	positive regulation of smooth muscle cell proliferation	GO:048661	14.4	SERPINF2, BMP4, S1PR1, JUN, FLT1, IL13
24	regulation of blood pressure	GO:008217	14.2	REN, SGK1, UTS2, LEP, CHGA, CD34
25	response to organic cyclic compound	GO:014070	14.0	NCF2, SELP, SERPINA1, BMP4, UGT1A1, ATF1
26	response to ethanol	GO:045471	13.9	CNR1, RBP4, BGLAP, BCL2, CHAT, LCT
27	extracellular matrix disassembly	GO:022617	13.6	CMA1, FURIN, MMP1, MMP10, MMP11, MMP13
28	response to estrogen stimulus	GO:043627	13.6	SERPINE1, BRCA1, BGLAP, BCL2, LCT, MSTN
29	heart development	GO:007507	13.6	PCNA, RBP4, VCAM1, VCAN, BMP2, RAF1
30	positive regulation of protein kinase B signaling cascade	GO:051897	13.6	PIK3CG, CHI3L1, ARRB2, INS, ILK, ANGPT1
31	positive regulation of nitric oxide biosynthetic process	GO:045429	13.6	JAK2, INS, IL1B, IFNG, ICAM1, HSP90AA1
32	wound healing	GO:042060	13.4	KLF6, RAF1, S100A8, P2RY2, INS, FGF10
33	positive regulation of phosphatidylinositol 3-kinase cascade	GO:014068	13.2	KIT, SELP, KDR, JAK2, FLT1, INS
34	positive regulation of MAP kinase activity	GO:043406	13.2	PIK3CG, KITLG, VEGFA, CD40, FLT1, FGFR1
35	response to mechanical stimulus	GO:009612	12.7	BMP2, BMP4, BGLAP, CHI3L1, P2RY1, JUN
36	negative regulation of cell proliferation	GO:008285	INF	RGCC, SFRP4, SERPINE2, VHL, VDR, BMP2
37	cell surface receptor signaling pathway	GO:007166	INF	BSG, LIFR, LEPR, P2RY1, MPL, JMJD6
38	immune response	GO:006955	INF	CNR2, VTN, SEMA7A, BPI, BMP6, RAG1
39	positive regulation of MAPK cascade	GO:043410	INF	KIT, LIF, KDR, LEP, CD36,
40	positive regulation of cell migration	GO:030335	INF	VEGFA, BMP2, KDR, S1PR1, FURIN, JAK2
41	apoptotic process	GO:006915	INF	SGK1, VIM, BRCA1, VDAC1, LMNA, RASSF6
42	chemotaxis	GO:006935	INF	S100A8, S100A9, FPR1, FGF2, IL4, ENPP2
43	positive regulation of protein phosphorylation	GO:001934	INF	PIN1, VEGFA, BMP2, BMP4, P2RY1, FZD1
44	anti-apoptosis	GO:006916	INF	PIK3CA, RELA, GCLC, VHL, BIRC5, BCL2
45	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	INF	KITLG, VTN, VEGFA, LIF, JAK2, CD36
46	positive regulation of apoptotic process	GO:043065	INF	CNR1, SFRP4, BMP2, BMP4, CLU, BAX
47	blood coagulation	GO:007596	INF	PIK3CA, PIK3CG, PDE3A, VWF, SELL, SELP
48	negative regulation of apoptotic process	GO:043066	INF	PIK3CG, PDE3A, RELA, SERPINE1, VEGFA, MYC
49	angiogenesis	GO:001525	INF	PIK3CA, PIK3CG, SETD2, SERPINE1, VEGFA, VEGFC
50	platelet activation	GO:030168	INF	PIK3CA, PIK3CG, VWF, SELP, SERPINF2, SERPINA1

Molecular functions related to fibrosis according to GeneDecks:

(show all 15)

id	Name	GO ID	Score	Top Affiliating Genes
1	protein binding	GO:005515	INF	PIK3CA, PIAS3, PIK3CG, PIN1, RGCC, NCF1
2	ATP binding	GO:005524	INF	PIK3CA, PIK3CG, SGK1, KIT, KIF21A, KIF16B
3	protease binding	GO:002020	INF	KIT, VWF, SELL, SERPINC1, SERPINF2, SERPINA1
4	receptor binding	GO:005102	19.4	REN, SERPINE2, SERPINE1, LPL, VCP, BMP2
5	cytokine activity	GO:005125	18.5	KITLG, VEGFA, BMP1, BMP2, BMP3, BMP4
6	chemokine activity	GO:008009	15.0	XCL1, IL8, CCL4, CCL7, CCL27, CCL22
7	hormone activity	GO:005179	14.6	KL, RETN, RETNLB, VIP, UTS2, SCT
8	heme binding	GO:020037	14.4	LPO, MPO, JAK2, FECH, FADS1, FADS2
9	calcium ion binding	GO:005509	INF	RCN1, GCA, VCAN, BMP1, UTRN, BGLAP
10	protein heterodimerization activity	GO:046982	INF	GCA, VEGFA, MYC, BMP2, BMP6, RARA
11	protein homodimerization activity	GO:042803	INF	KIT, VWF, SFTPC, GCA, SERPINF2, NAGA
12	growth factor activity	GO:008083	INF	REG1A, KITLG, VEGFA, VEGFC, BMP1, BMP2
13	integrin binding	GO:005178	INF	VWF, VTN, SEMA7A, VCAM1, KDR, ITGA1
14	heparin binding	GO:008201	INF	VTN, SELL, SELP, SERPINE2, SERPINC1, VEGFA
15	enzyme binding	GO:019899	INF	PIAS3, BRCA1, VHL, RARA, BIRC5, BCHE