MCID: FBR009
MIFTS: 44

Fibrous Dysplasia malady

Categories: Rare diseases, Bone diseases

Aliases & Classifications for Fibrous Dysplasia

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Aliases & Descriptions for Fibrous Dysplasia:

Name: Fibrous Dysplasia 11 46 13 48 66
 
Fibrous Dysplasia of Bone 46

Classifications:



External Ids:

Disease Ontology11 DOID:0080031
ICD1028 M85.0

Summaries for Fibrous Dysplasia

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NIH Rare Diseases:46 Fibrous dysplasia is a skeletal disorder that is characterized by the replacement of normal bone with fibrous bone tissue. it may involve one bone (monostotic) or multiple bones (polyostotic). fibrous dysplasia can affect any bone in the body. the most common sites are the bones in the skull and face, the long bones in the arms and legs, the pelvis, and the ribs. though many individuals with this condition do not have any symptoms, others may have bone pain, abnormally shaped bones, or an increased risk of fractures (broken bones). this condition can occur alone or as part of a genetic disorder, such as mccune-albright syndrome. while there is no cure for fibrous dysplasia, the symptoms can be treated. medications known as bisphosphonates can reduce pain and surgery may be indicated for fractures or to correct misshapen bones.  last updated: 4/4/2016

MalaCards based summary: Fibrous Dysplasia, also known as fibrous dysplasia of bone, is related to fibroma and prolactinoma. An important gene associated with Fibrous Dysplasia is GNAS (GNAS Complex Locus), and among its related pathways are Osteoblast Signaling and Development_Hedgehog and PTH signaling pathways in bone and cartilage development. Affiliated tissues include bone, bone marrow and brain, and related mouse phenotypes are neoplasm and limbs/digits/tail.

Disease Ontology:11 A bone remodeling disease that results in the destruction of normal bone and replacing it with fibrous bone tissue.

Related Diseases for Fibrous Dysplasia

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Diseases related to Fibrous Dysplasia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 215)
idRelated DiseaseScoreTop Affiliating Genes
1fibroma30.6GNAS, SST
2prolactinoma29.5IGF1, SST
3monostotic fibrous dysplasia12.4
4panostotic fibrous dysplasia12.1
5fibrous dysplasia/mccune-albright syndrome12.1
6mccune-albright syndrome, somatic, mosaic12.0
7mazabraud syndrome11.6
8osteofibrous dysplasia11.5
9cherubism11.3
10properdin deficiency, x-linked10.9
11spastic ataxia10.6FGF23, IBSP
12sensory peripheral neuropathy10.6FGF23, GNAS
13gestational diabetes10.6BGLAP, FGF23
14papillary adenocarcinoma10.6BGLAP, SPARC
15breast capillary hemangioma10.6BGLAP, SPARC
16obesity, severe bmiq910.6BGLAP, GNAS
17intracranial arteriovenous malformation10.5BGLAP, SPARC
18aromatase excess syndrome10.5BGLAP, GH1
19aneurysm or dilatation of ascending aorta10.5GH1, PRL
20parathyroid transitional clear cell adenoma10.4BGLAP, CALCA
21nodular goiter10.4BGLAP, CALCA
22primary biliary cholangitis10.4GNAS, IGF1
23dyscalculia10.4BGLAP, CALCA
24periodic paralyses10.4CALCA, FGF23
25bone lymphoma10.4CALCA, SPARC
26alpha chain disease10.4CDC73, GNAS
27aortic valve atresia10.4GH1, PRL
28cannabis dependence10.3BGLAP, IBSP, SPARC
29growth hormone insensitivity, partial10.3GH1, IGF1
30neuritis10.3CDC73, GNAS
31nail disorder, nonsyndromic congenital, 110.3BGLAP, SPARC
32glioblastoma classical subtype10.3AR, PRL
33aneurysmal bone cysts10.3
34aneurysm10.3
35echolalia10.3BGLAP, GNAS, PRL
36bacillary angiomatosis10.3BGLAP, CALCA
37fibrosclerosis of breast10.3IGF1, PRL
38ossifying fibroma10.3
39acquired hyperkeratosis10.3BGLAP, CALCA
40fumarate hydratase deficiency10.3GH1, GNAS, PRL
41immune system organ benign neoplasm10.2IGF1, PRL
42scrotal carcinoma10.2BGLAP, CALCA
43gaucher's disease10.2AR, PRL
44capillariasis10.2BGLAP, CALCA, FGF23
45cervicitis10.2
46leukodystrophy10.2BGLAP, CALCA, FGF23
4749, xxxxx10.2GH1, PRL
48status epilepticus10.2CALCA, FGF23, SPARC
49lung occult small cell carcinoma10.2BGLAP, CALCA, IBSP
50brain stem angioblastoma10.2BGLAP, CALCA, IBSP

Graphical network of the top 20 diseases related to Fibrous Dysplasia:



Diseases related to fibrous dysplasia

Symptoms for Fibrous Dysplasia

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Drugs & Therapeutics for Fibrous Dysplasia

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Drugs for Fibrous Dysplasia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1Risedronate SodiumPhase 2, Phase 398115436-72-1
2
Etidronic acidPhase 2, Phase 3827414-83-7, 2809-21-43305
Synonyms:
(1-Hydroxyethylene)diphosphonic acid
(1-Hydroxyethylidene)bis(phosphonic acid)
(1-Hydroxyethylidene)bisphosphonic acid
(1-Hydroxyethylidene)diphoshonic acid
(1-Hydroxyethylidene)diphosphonic acid
(1-hydroxy-1-phosphonoethyl)phosphonic acid
(1-hydroxy-ethylidene)diphosphonic acid
(1-hydroxyethane-1,1-diyl)bis(phosphonic acid)
(Hydroxyethylidene)diphosphonic acid
0-02-00-00171 (Beilstein Handbook Reference)
1,1,1-Ethanetriol diphosphonate
1-HYDROXY-1,1-DIPHOSPHONOETHANE
1-Hydroxy-1,1-diphosphonoethane
1-Hydroxyethane-1,1,-diphosphonic acid
1-Hydroxyethane-1,1-bisphosphonic acid
1-Hydroxyethane-1,1-diphosphonate
1-Hydroxyethane-1,1-diphosphonic acid
1-Hydroxyethanediphosphonic acid
1-Hydroxyethylidene 1,1-diphosphonic acid
1-Hydroxyethylidene-1,1-biphosphonate
1-Hydroxyethylidene-1,1-bisphosphonate
1-Hydroxyethylidene-1,1-diphosphonic acid
1-Hydroxyethylidenediphosphonic acid
1-hydroxyethane 1,1-diphosphonic acid
1000SL
100511-44-2
103736-66-9
106908-76-3
129130-42-3
138360-84-6
14860-53-8 (tetra-potassium salt)
192526-55-9
2809-21-4
303177-33-5
51888-66-5
54342_ALDRICH
54342_FLUKA
66216-98-6
853028-38-3
85985-26-8
86159-18-4
AC1L1FMT
Acetodiphosphonic acid
Acide etidronique
Acide etidronique [INN-French]
Acido etidronico
Acido etidronico [INN-Spanish]
Acidum etidronicum
Acidum etidronicum [INN-Latin]
BPBio1_000997
BRN 1789291
BSPBio_000905
Bio-0708
C07736
CHEBI:170675
CHEBI:4907
CHEMBL871
CID3305
 
Cintichem Technetium 99m Hedspa
D02373
DB01077
Dequest 2010
Dequest 2015
Dequest Z 010
Didronel
Didronel IV
Diphosphonate (base)
EHDP
EINECS 220-552-8
Ethane-1-hydroxy-1,1-bisphosphonate
Ethane-1-hydroxy-1,1-bisphosphonic acid
Ethane-1-hydroxy-1,1-diphosphonate
Ethane-1-hydroxy-1,1-diphosphonic acid
Etidronate
Etidronate Disodium
Etidronic acid
Etidronic acid (USAN/INN)
Etidronic acid [USAN:INN:BAN]
Etidronic acid monohydrate
Etidronsaeure
Etidronsäure
Ferrofos 510
H0587
H6773_ALDRICH
H6773_SIGMA
HEDP
HSDB 5898
Hydroxyethane-1,1-diphosphonic acid
Hydroxyethanediphosphonic acid
I14-1271
Jsp005415
LS-106637
MLS002207267
MLS002695948
MPI Stannous Diphosphonate
MolPort-001-786-542
NCGC00159352-02
NSC 227995
NSC227995
Osteoscan
Oxyethylidenediphosphonic acid
Phosphonic acid, 1-hydroxy-1,1-ethanediyl ester
Prestwick0_000863
Prestwick1_000863
Prestwick2_000863
Prestwick3_000863
RP 61
SMR000038750
SPBio_002826
STK721995
Turpinal SL
UNII-M2F465ROXU
acide étidronique
acidum etidronicum
ethane-1-hydroxy-1,1-bisphosphonic acid
etidronate
ácido etidrónico
3calcium channel blockersPhase 2, Phase 31889
4
AnastrozolePhase 2266120511-73-12187
Synonyms:
.alpha.,alpha.,.alpha.',.alpha.'-tetramethyl-5(1H-1,2,4-triazol-1-ylmethyl)-m-benzenediacetonitrile
1,3-benzenediacetonitrile, a, a, a', a'-tetramethyl-5-(1H-1,2,4-triazol-1-ylmethyl)
120511-73-1
2,2'-(5-(1H-1,2,4-triazol-1-ylmethyl)-1,3-phenylene)bis(2-methylpropionitrile)
2,2'-[5-(1H-1,2,4-triazol-1-ylmethyl)-1,3-phenylene]bis(2-methylpropanenitrile)
2,2'-[5-(1H-1,2,4-triazol-1-ylmethyl)benzene-1,3-diyl]bis(2-methylpropanenitrile)
2-[3-(2-cyanopropan-2-yl)-5-(1,2,4-triazol-1-ylmethyl)phenyl]-2-methylpropanenitrile
AC-4234
AC1L1D49
Anastrazole
Anastrole
Anastrozol
Anastrozole (JAN/USAN/INN)
Anastrozole [USAN:INN:BAN]
Arimidex
Arimidex (TN)
Arimidex (Zeneca)
Arimidex, Anastrozole
Asiolex
Astra brand of anastrozole
AstraZeneca brand of anastrozole
C08159
C090450
C17H19N5
CHEBI:2704
CHEMBL1399
CID2187
CPD000466301
 
D00960
DB01217
HMS2052M11
HMS2089N10
HSDB 7462
I06-0021
ICI D1033
ICI-D 1033
ICI-D1033
LS-29563
MLS000759396
MLS001424217
MolPort-005-933-078
NCGC00164619-01
NSC719344
S1188_Selleck
SAM001246525
SBB066057
SMR000466301
UNII-2Z07MYW1AZ
ZD 1033
ZD-1033
ZD1033
ZINC00000941
Zeneca ZD 1033
Zeneca brand of anastrozole
alpha,alpha,Alpha',alpha'-tetramethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-m-benzenediacetonitrile
alpha,alpha,alpha',alpha'-Tetramethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-m-benzenediacetonitrile
anastrazole
anastrozole
5
TestolactonePhase 24968-93-413769
Synonyms:
(4AS,4br,10ar,10bs,12as)-10a,12a-dimethyl-3,4,4a,5,6,10a,10b,11,12,12a-decahydro-2H-naphtho[2,1-F]chromene-2,8(4bh)-dione
(4aS,4bR,10aR,10bS,12aS)-10a,12a-dimethyl-3,4,4a,5,6,10a,10b,11,12,12a-decahydro-2H-naphtho[2,1-f]chromene-2,8(4bH)-dione
(4aS,4bR,10aR,10bS,12aS)-10a,12a-dimethyl-4,4a,4b,5,6,10b,11,12-octahydro-3H-naphtho[2,1-f]chromene-2,8-dione
.DELTA.1-Dehydrotestolactone
.DELTA.1-Dehydrotestololactone
.DELTA.1-Testololactone
1 Dehydrotestolactone
1,2,3,4,4a,4b,7,9,10,10a-Decahydro-2-hydroxy-2,4b-dimethyl-7-oxo-1-phenanthrenepropionic acid delta-lactone
1,2-Dehydrotestololactone
1,2-Didehydrotestololactone
1,2-didehydrotestololactone
1-Dehydrotestolactone
1-Dehydrotestololactone
1-dehydrotestololactone
13,17-Secoandrosta-1,4-dien-17-oic acid, 13-hydroxy-3-oxo-, .delta.-lactone
13,17-Secoandrosta-1,4-dien-17-oic acid, 13-hydroxy-3-oxo-, delta-lactone
13,17-Secoandrosta-1,4-dien-17-oic acid, 13-hydroxy-3-oxo-, delta-lactone (8CI)
13,17-Secoandrosta-1,4-dien-17-oic acid, 13-hydroxy-3-oxo-, lactone
13,17-Secoandrosta-1,4-dien-17-oic acid, 13.alpha.-hydroxy-3-oxo-, .delta.-lactone
13-Hydroxy-3-oxo-13,17-secoandrosta-1,4-dien-17-oic acid .delta.-lactone
13-Hydroxy-3-oxo-13,17-secoandrosta-1,4-dien-17-oic acid delta-lactone
17a-Oxa-D-homoandrosta-1,4-diene-3,17-dione
17alpha-Oxo-D-homo-1,4-androstadiene-3,17-dione
2H-Phenanthro[2,1-b]pyran-2,8(4bH)-dione, 3,4,4a,5,6,10a,10b,11,12,12a-decahydro-10a,12a-dimethyl-, lactone
3-oxo-13,17-secoandrosta-1,4-dieno-17,13alpha-lactone
968-93-4
AC1L22FS
Bristol Myers Squibb Brand of Testolactone
Bristol-Myers Squibb Brand of Testolactone
C02197
C19H24O3
CHEBI:9460
CHEMBL1571
CID13769
D-Homo-17A-oxaandrosta-1,4-diene-3,17-dione
D-Homo-17a-oxaandrosta-1,4-diene-3,17-dione
 
D00153
D013738
DB00894
Delta(1)-testololactone
Delta-1-testololactone
EINECS 213-534-6
Fludestrin
HSDB 3255
LMST02020084
LS-102968
MolPort-004-286-011
NCI60_001908
NSC 23759
NSC-12173
NSC23759
SQ 9538
SQ-9538
TESLAC (TN)
Teolit
Teslac
Teslak
Testolacton
Testolactona
Testolactona [INN-Spanish]
Testolactone
Testolactone (USP/INN)
Testolactone [USAN:INN]
Testolactonum
Testolactonum [INN-Latin]
Testolattone
Testolattone [DCIT]
Testolattone [Dcit]
UNII-6J9BLA949Q
ZINC04081771
delta(1)-Dehydrotestolactone
delta(1)-Testolactone
delta(1)-Testololactone
6
AlendronatePhase 2157121268-17-5, 66376-36-12088
Synonyms:
(4-Amino-1-hydroxybutylidene)bisphosphonic acid
(4-Amino-1-hydroxybutylidene)diphosphonic acid
(4-amino-1-hydroxy-1-phosphonobutyl)phosphonic acid
(4-amino-1-hydroxybutane-1,1-diyl)bis(phosphonic acid)
(4-amino-1-hydroxybutylidene)bisphosphonic acid
121268-17-5 (mono-hydrochloride salt, trihydrate)
1yhm
4-Amino-1-hydroxybutane-1,1-diphosphonate
4-Amino-1-hydroxybutane-1,1-diphosphonic Acid
4-Amino-1-hydroxybutylidene-1,1-bis(phosphonic acid)
4-Amino-1-hydroxybutylidene-1,1-bisphosphonate
4-amino-1-hydroxybutane-1,1-diphosphonic acid
66376-36-1
ABDP
AC1L1CW3
AKOS001015793
ALENDRONATE SODIUM
ALENDRONIC ACID
Acide Alendronique
Acide Alendronique [INN-French]
Acide alendronique
Acide alendronique [INN-French]
Acido Alendronico
Acido Alendronico [INN-Spanish]
Acido alendronico
Acido alendronico [INN-Spanish]
Acidum Alendronicum
Acidum Alendronicum [INN-Latin]
Acidum alendronicum
Acidum alendronicum [INN-Latin]
Adronat
 
Alendronate
Alendronate Sodium
Alendronate sodium hydrate
Alendronic acid
Alendronic acid (INN)
Alendronic acid [INN:BAN]
Alendros
Arendal
BIDD:GT0180
C07752
CHEBI:2567
CHEMBL870
CID2088
D07119
DB00630
Fosamax
Fosamax Plus D
HSCI1_000337
LS-106421
MK 217
MK-217
MolPort-000-421-410
NCGC00096054-01
NCGC00096054-03
NCGC00096054-04
Onclast
Oprea1_422906
Phosphonic acid, (4-amino-1-hydroxybutylidene)bis
SPECTRUM1505166
ST50036159
UNII-X1J18R4W8P
alendronate
bisphosphonate, 65
7
FulvestrantPhase 2182129453-61-8104741, 17756771
Synonyms:
(7R,13S,17S)-13-methyl-7-(9-(4,4,5,5,5-pentafluoropentylsulfinyl)nonyl)-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3,17-diol
(7R,8R,9S,13S,14S,17S)-13-methyl-7-[9-(4,4,5,5,5-pentafluoropentylsulfinyl)nonyl]-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol
(7R,8S,9S,13S,14S,17S)-13-methyl-7-[9-(4,4,5,5,5-pentafluoropentylsulfinyl) nonyl]-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol
(7alpha,17beta)-7-{9-[(4,4,5,5,5-pentafluoropentyl)sulfinyl]nonyl}estra-1,3,5(10)-triene-3,17-diol
129453-61-8
7-(9-(4,4,5,5,5-pentafluoropentylsulfinyl)nonyl)estra-1,3,5(10)-triene-3,17-diol
7alpha-(9-((4,4,5,5,5,-Pentafluoropentyl)sulfinyl)nonyl)estra-1,3,5(10)-triene-3,17beta-diol
7alpha-(9-((4,4,5,5,5-Pentafluoropentyl)sulfinyl)nonyl)estra-1,3,5(10)-triene-3,17beta-diol
7alpha-[9[(4,4,5,5,5-Pentafluropentyl)sulfinyl]nonyl]-estra-1,3,5(10)-triene-3, 17 beta diol
AC-4693
AC1L2XEN
AstraZeneca brand of fulvestrant
BIDD:ER0348
BIDD:PXR0136
C070081
C32H47F5O3S
CCRIS 8741
CHEBI:404798
CHEMBL1358
CID104741
D01161
DB00947
Faslodex
Faslodex (TN)
 
Faslodex(ICI 182,780)
Faslodex, ICI 182780, Fulvestrant
Fulvestrant
Fulvestrant (JAN/USAN/INN)
Fulvestrant [USAN]
HMS2090N22
HSDB 7658
I06-1109
ICI 182,780
ICI 182,789
ICI-182780
Ici 182780
LS-64781
NCGC00164789-02
NSC719276
S1191_Selleck
UNII-22X328QOC4
ZD 182780
ZD-182780
ZD-9238
ZM 182780
ZM-182780
fulvestrant
nchembio.168-comp5
nchembio.76-comp5
nchembio775-comp4
8
LetrozolePhase 1368112809-51-53902
Synonyms:
1-[Bis-(4-cyanophenyl)methyl]-1,2,4-triazole
1-[bis(4-cyanophenyl)methyl]-1,2,4-triazole
112809-51-5
4,4'-((1h-1,2,4-triazol-1-yl)methylene)dibenzonitrile
4,4'-(1H-1,2,4-Triazol-1-ylmethylene)dibenzonitrile
4,4'-(1H-1,2,4-triazol-1-yl-methylene)-bis(benzonitrile)
4,4'-(1H-1,2,4-triazol-1-ylmethanediyl)dibenzonitrile
4,4'-(1H-1,2,4-triazol-1-ylmethylene)bis-Benzonitrile Letrozole
4,4'-(1h-1,2,4-triazol-1-ylmethylene) bis-benzonitrile
4,4'-(1h-1,2,4-triazol-1-ylmethylene)bis-benzonitrile
4,4'-(1h-1,2,4-triazol-1-ylmethylene)bisbenzonitrile
4-[(4-cyanophenyl)-(1,2,4-triazol-1-yl)methyl]benzonitrile
AB00514009
AC-1193
AC1L1GYT
AKOS005145822
BIDD:GT0015
BIDD:PXR0130
BPBio1_001331
BRD-K88789588-001-03-2
BSPBio_001209
Bio-0057
C067431
C08163
C17H11N5
CAS-112809-51-5
CCRIS 8822
CGS 20267
CGS 20267, Femara, Piroxicam, Letrozole
CGS-20267
CHEBI:6413
CHEMBL1444
CID3902
CPD000466343
D00964
 
DB01006
FEM-345
Femara
Femara (TN)
Femera
HMS1571M11
HMS2051E08
HMS2089L22
HSDB 7461
I06-0022
LS-38788
Letoval
Letrozol
Letrozole
Letrozole (JAN/USP/INN)
Letrozole [USAN:INN]
MLS000759455
MLS001424038
MLS002584991
MolPort-003-848-373
NCGC00016973-01
NCGC00016973-02
NSC719345
Novartis Brand of Letrozole
Prestwick0_001025
Prestwick1_001025
Prestwick2_001025
Prestwick3_001025
S1235_Selleck
SAM001246649
SMR000466343
SPBio_003070
TL8000371
UNII-7LKK855W8I
ZINC03778874
letrozole
9
Histamine Phosphate100851-74-165513
Synonyms:
1H-Imidazole-4-ethanamine, phosphate (1:2)
2-Imidazol-4-ylethylamine orthophosphoric acid (1:2)
4-(2-Aminoethyl)imidazole bis(dihydrogen phosphate)
4-(2-Aminoethyl)imidazole di-acid phosphate
4-2(2-Aminoethyl)Imidazole-Di-Acid Phosphate
51-74-1
53623-99-7
74-56-6
AC1L23E4
CID65513
D04445
DB00667
 
EINECS 200-118-4
H0147
Histamine acid phosphate
Histamine biphosphate
Histamine dihydrogen phosphate
Histamine diphosphate
Histamine phosphate (1:2)
Histamine phosphate (TN)
Histamine phosphate (USP)
Histamine phosphate [USP]
Histamine positive
Histaminum
LS-78569
UNII-QWB37T4WZZ
10
histamine100975614-87-8, 51-45-6774
Synonyms:
.beta.-Imidazolyl-4-ethylamine
1H-Imidazole-4-ethanamine
1H-Imidazole-5-ethanamine
1avn
1qft
2-(1H-Imidazol-4-yl)ethanamine
2-(1H-Imidazol-4-yl)ethylamine
2-(1H-Imidazol-5-yl)ethanamine
2-(1H-Imidazol-5-yl)ethylamine
2-(1H-imidazol-4-yl)ethan-1-amine
2-(1H-imidazol-5-yl)ethanamine
2-(3H-Imidazol-4-yl)-ethylamine
2-(4-Imidazolyl)ethanamine
2-(4-Imidazolyl)ethylamine
2-Imidazol-4-yl-Ethylamine
2-Imidazol-4-ylethylamine
2-[4-Imidazolyl]ethylamine
4-(2-Aminoethyl)-1H-imidazole
4-(2-Aminoethyl)imidazole
4-Imidazoleethylamine
5-Imidazoleethylamine
51-45-6
53290_FLUKA
64422-25-9
924364-91-0
AC-13185
AC1L19ZT
AC1Q54BV
AC1Q54BW
AKOS000274386
ALBB-005968
BCBcMAP01_000250
BSPBio_001117
BSPBio_002124
Bio1_000487
Bio1_000976
Bio1_001465
Bio2_000389
Bio2_000869
C00388
CCRIS 6535
CHEBI:18295
CHEMBL90
CID774
D08040
DivK1c_000308
EINECS 200-100-6
Eramin
Ergamine
Ergotidine
F411C768-A159-4FC0-A195-291A08BB03AA
Free histamine
H7125_SIGMA
HMS1362G19
HMS1792G19
HMS1990G19
HSDB 3338
HSM
Histamine
Histamine (DCF)
Histamine Base
Histamine [USAN]
Histamine, Free Base
Histaminum
 
Histaminum (TN)
IDI1_000308
IDI1_002144
Imidazole-4-ethylamine
Istamina
Istamina [Italian]
KBio1_000308
KBio2_000457
KBio2_001325
KBio2_003025
KBio2_003893
KBio2_005593
KBio2_006461
KBio3_000853
KBio3_000854
KBio3_001344
KBioGR_000457
KBioGR_001580
KBioSS_000457
KBioSS_001325
L-Histamin base
L-Histamine
L-histamine
L000292
LS-75835
Lopac-H-7250
Lopac0_000595
MLS000069447
MolPort-001-785-597
MolPort-002-042-264
NCGC00015513-01
NCGC00015513-08
NCGC00093371-02
NCGC00093371-03
NCGC00093371-04
NCGC00093371-05
NINDS_000308
NSC 33792
NSC33792
SDCCGMLS-0066601.P001
SMP1_000151
SMR000059091
SPBio_000729
ST073926
STK346752
STOCK5S-55669
Spectrum2_000665
Spectrum3_000452
Spectrum4_000960
Spectrum5_000796
Spectrum_000845
Theramine
UNII-820484N8I3
WLN: T5M CNJ D2Z
ZERO/004089
[3H]histamine
b-Imidazolyl-4-ethylamine
beta-Aminoethylglyoxaline
beta-Aminoethylimidazole
beta-Aminothethylglyoxaline
beta-Imidazolyl-4-ethylamine
beta-aminothethylglyoxaline
bmse000744
histamine
nchembio.87-comp54
nchembio714-comp1

Interventional clinical trials:

(show all 17)
idNameStatusNCT IDPhase
1A Study of the Effects of Pegvisomant on Growth Hormone Excess in McCune-Albright SyndromeCompletedNCT00017927Phase 3
2Effect of Risedronate on Bone Morbidity in Fibrous Dysplasia of BoneRecruitingNCT00445575Phase 2, Phase 3
3Alendronate to Treat Polyostotic Fibrous Dysplasia and McCune-Albright SyndromeCompletedNCT00001728Phase 2
4Testolactone for the Treatment of Girls With LHRH Resistant Precocious PubertyCompletedNCT00001181Phase 2
5Arimidex in McCune Albright SyndromeCompletedNCT00055302Phase 2
6TOCILIZUMAB IN FIBROUS DYSPLASIA OF BONERecruitingNCT01791842Phase 2
7PET Imaging of Phosphodiesterase-4 (PDE4) in Brain and Peripheral Organs of McCune-Albright SyndromeRecruitingNCT02743377Phase 1, Phase 2
8Faslodex in McCune Albright SyndromeActive, not recruitingNCT00278915Phase 2
9Effects of Letrozole on Precocious Puberty Due to McCune Albright SyndromeCompletedNCT00006174Phase 1
10Studies on Abnormal Bone From Patients With Polyostotic Fibrous Dysplasia and McCune Albright SyndromeCompletedNCT00001973
11Bone Marrow Injection to Replace Diseased Bone in Polyostotic Fibrous Dysplasia and McCune-Albright SyndromeCompletedNCT00001851
12The Influence of Bisphosphonates in the Oral Cavity in ChildrenCompletedNCT00402064
13Interest of Serum Periostin Dosage in Patients With Bone Fibrous DysplasiaRecruitingNCT02868645
14Screening and Natural History of Patients With Polyostotic Fibrous Dysplasia and McCune-Albright SyndromeRecruitingNCT00001727
15Histamine Responsiveness in McCune-Albright SyndromeRecruitingNCT00318097
16Natural History of Cherubism Observational StudyRecruitingNCT01916772
17Genetic and Functional Analysis of CherubismRecruitingNCT01630447

Search NIH Clinical Center for Fibrous Dysplasia

Genetic Tests for Fibrous Dysplasia

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Anatomical Context for Fibrous Dysplasia

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MalaCards organs/tissues related to Fibrous Dysplasia:

34
Bone, Bone marrow, Brain, B cells, Pituitary, Myeloid, Tongue

Animal Models for Fibrous Dysplasia or affiliated genes

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MGI Mouse Phenotypes related to Fibrous Dysplasia:

39
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.0AR, GNAS, IGF1, PRL, SPARC
2MP:00053717.7AR, FGF23, GNAS, IBSP, IGF1, SPARC
3MP:00107717.5AR, CDC73, FGF23, GNAS, IGF1, PRL
4MP:00053907.5AR, FGF23, GNAS, IBSP, IGF1, SPARC
5MP:00053876.4AR, CDC73, FGF23, GNAS, IBSP, IGF1

Publications for Fibrous Dysplasia

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Articles related to Fibrous Dysplasia:

(show top 50)    (show all 749)
idTitleAuthorsYear
1
Maxillofacial fibrous dysplasia: a diagnostic challenge. (27358102)
2016
2
Fibrous dysplasia with secondary osteosarcoma - A rare presentation of a common disease. (27147164)
2016
3
Fibrocartilaginous Dysplasia of the Bone: A Rare Variant of Fibrous Dysplasia. (26918216)
2016
4
Craniospinal Polyostotic Fibrous Dysplasia, Aneurysmal Bone Cysts, and Chiari Type 1 Malformation Coexistence in a Patient with McCune-Albright Syndrome. (27161212)
2016
5
Monostotic fibrous dysplasia of the thoracic spine: A case report. (26577280)
2015
6
Changing Pattern of Femoral Deformity During Growth in Polyostotic Fibrous Dysplasia of the Bone: An Analysis of 46 Cases. (25887818)
2015
7
Case report: Fibrous dysplasia of the navicular bone treated with excision of navicular and talo-cuneiform arthrodesis. (25542678)
2015
8
Surgical management of maxillofacial fibrous dysplasia under navigational guidance. (25660597)
2015
9
En bloc resection and bone graft: does it alter the natural history of monostotic expansile fibrous dysplasia in children? (25407316)
2014
10
Monostotic fibrous dysplasia of the mandible. (24984642)
2014
11
An unusual case of intraosseous vascular malformation of the maxilla mimicking fibrous dysplasia: a case report and literature review on imaging features of intraosseous vascular anomalies of the jaw. (24940806)
2014
12
Pathological fracture of the femoral neck revealing a fibrous dysplasia of bone. (25860688)
2014
13
Fibrous dysplasia of the craniofacial bones. (23918916)
2013
14
Low-grade central osteosarcoma of distal femur, resembling fibrous dysplasia. (24147271)
2013
15
Fibrous dysplasia and central giant cell granuloma: a report of hybrid lesion with its review and hypotheticated pathogenesis. (23814754)
2013
16
Isolated fibrous dysplasia of the inferior turbinate. (22698592)
2013
17
Real-time image-guided recontouring in the management of craniofacial fibrous dysplasia. (24113350)
2013
18
Clinical guidelines for the management of craniofacial fibrous dysplasia. (22640797)
2012
19
Peritrabecular clefting in fibrous dysplasia of the jaws: an important histopathologic feature for differentiating fibrous dysplasia from central ossifying fibroma. (22986246)
2012
20
Clinicoradiologic perspective of a severe case of polyostotic fibrous dysplasia. (22923911)
2012
21
Surgical treatment of monostotic fibrous dysplasia of the temporal bone: a retrospective analysis. (22795233)
2012
22
Long-term efficacy of oral alendronate therapy in an elderly patient with polyostotic fibrous dysplasia: A case report. (22848294)
2011
23
Fibrous dysplasia and aneurysmal bone cyst of the skull base presenting with blindness: a report of a rare locally aggressive example. (21396116)
2011
24
Chest wall reconstruction in a patient with sternal fibrous dysplasia. (21243578)
2011
25
Monofocal maxillary fibrous dysplasia with orbital, nasal and oral obstruction. (19540186)
2010
26
Periostin, a novel marker of intramembranous ossification, is expressed in fibrous dysplasia and in c-Fos-overexpressing bone lesions. (18799196)
2009
27
Oral rehabilitation with endosseous implants in a patient with fibrous dysplasia (McCune-Albright syndrome): a case report. (19022142)
2008
28
Intensity of FDG uptake is not everything: synchronous liposarcoma and fibrous dysplasia in the same patient on FDG PET-CT imaging. (18580228)
2008
29
Attention deficiency hyperactivity disorder and sphenoid bone fibrous dysplasia association in a boy: SPECT/SPECT fusion imaging. (18075425)
2007
30
Fibrous dysplasia of the clivus, a case report. (21503248)
2007
31
A sensitive mutation-specific screening technique for GNAS1 mutations in cases of fibrous dysplasia: the first report of a codon 227 mutation in bone. (17493233)
2007
32
Craniofacial fibrous dysplasia and hypophysial microadenoma with Hodgkin's lymphoma: unusual involution of an extensive case. (16860225)
2006
33
Surgery for fibrous dysplasia. (17228997)
2006
34
Aneurysmal bone cyst arising from fibrous dysplasia of the frontal bone (2004:2b). (15162799)
2004
35
Chondroblastoma of the acromion mimicking fibrous dysplasia. (15669467)
2004
36
Fibrous dysplasia in the accessory carpal bone of a horse. (14756380)
2004
37
Mazabraud's syndrome: intramuscular myxoma associated with fibrous dysplasia. (15188030)
2004
38
Remodeling of the tibia after grafting of a large cavity with particulate bioactive glass-hydroxylapatite--case report on treatment of fibrous dysplasia with 13 years' follow-up. (14763713)
2003
39
Comparative study of fibrous dysplasia and osteofibrous dysplasia: histopathological, immunohistochemical, argyrophilic nucleolar organizer region and DNA ploidy analysis. (11564214)
2001
40
Fibrous dysplasia of bone in the McCune-Albright syndrome: abnormalities in bone formation. (9403710)
1997
41
McCune-Albright syndrome (polyostotic fibrous dysplasia) with intracranial frontoethmoid mucocele. (9141412)
1997
42
Residents' corner. Answer to case of the month #12. McCune-Albright syndrome (polyostotic fibrous dysplasia). (1562893)
1992
43
Fibrous dysplasia of the mandible associated with large solitary bone cyst. (2294217)
1990
44
McCune-Albright syndrome (fibrous dysplasia) associated with an orbital tumor. (6712072)
1984
45
Pseudopseudohypoparathyroidism with fibrous dysplasia. (1119829)
1975
46
Familial polyostotic fibrous dysplasia. (1060033)
1975
47
Non-epithelial tumors of the nasal cavity, paranasal sinuses, and nasopharynx. A clinicopathologic study. II. Osseous and fibro-osseous lesions, including osteoma, fibrous dysplasia, ossifying fibroma, osteoblastoma, giant cell tumor, and osteosarcoma. (4207295)
1974
48
MONOSTOTIC FIBROUS DYSPLASIA AFFECTING THE SKULL AND FACIAL BONES. (14290332)
1965
49
MONOSTOTIC FIBROUS DYSPLASIA OF THE PARANASAL SINUSES. (14270683)
1965
50
Monostotic fibrous dysplasia. (18114634)
1949

Variations for Fibrous Dysplasia

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Expression for genes affiliated with Fibrous Dysplasia

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Search GEO for disease gene expression data for Fibrous Dysplasia.

Pathways for genes affiliated with Fibrous Dysplasia

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GO Terms for genes affiliated with Fibrous Dysplasia

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Cellular components related to Fibrous Dysplasia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1membrane-bounded vesicleGO:003198810.2BGLAP, IBSP, SPARC
2extracellular spaceGO:00056157.5BGLAP, CALCA, FGF23, GH1, IBSP, IGF1
3extracellular regionGO:00055766.6BGLAP, CALCA, FGF23, GH1, IBSP, IGF1

Biological processes related to Fibrous Dysplasia according to GeneCards Suite gene sharing:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1cellular response to vitamin DGO:007130510.4BGLAP, FGF23
2response to gravityGO:000962910.3BGLAP, SPARC
3JAK-STAT cascade involved in growth hormone signaling pathwayGO:006039710.2GH1, PRL
4regulation of bone mineralizationGO:003050010.1BGLAP, FGF23
5bone mineralizationGO:003028210.1BGLAP, IBSP
6positive regulation of tyrosine phosphorylation of Stat5 proteinGO:004252310.0GH1, IGF1
7bone developmentGO:006034810.0BGLAP, GNAS, SPARC
8positive regulation of JAK-STAT cascadeGO:00464279.9GH1, PRL
9cellular response to growth factor stimulusGO:00713639.7BGLAP, IBSP, SPARC
10response to glucocorticoidGO:00513849.7BGLAP, IGF1, SPARC
11regulation of multicellular organism growthGO:00400149.5IGF1, PRL
12cellular protein metabolic processGO:00442679.3CALCA, IGF1, PRL
13positive regulation of insulin-like growth factor receptor signaling pathwayGO:00435689.3AR, GH1, IGF1
14response to heatGO:00094088.8CALCA, IGF1, SST

Molecular functions related to Fibrous Dysplasia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1insulin-like growth factor receptor bindingGO:000515910.2GNAS, IGF1
2prolactin receptor bindingGO:000514810.2GH1, PRL
3growth factor activityGO:00080839.4FGF23, GH1, IGF1
4steroid bindingGO:00054968.9AR, IGF1
5hormone activityGO:00051798.4CALCA, GH1, IGF1, PRL, SST

Sources for Fibrous Dysplasia

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet