Fibrous Dysplasia malady

NIH Rare Diseases: Fibrous dysplasia is a progressive bone disorder that is characterized by the replacement of normal bone with weaker tissues, such as fibrous tissue and woven bone.  It may involve one bone (monostotic) or multiple bones (polyostotic).  Though many individuals with this condition do not have any symptoms, others may have bone pain, abnormally shaped bones, or an increased risk of breaking bones.  This condition can occur alone or as part of a genetic disorder, such as McCune-Albright syndrome.³⁰

MalaCards: Fibrous Dysplasia, also known as fibrous dysplasia of bone, is related to mccune albright syndrome and osteofibrous dysplasia. An important gene associated with Fibrous Dysplasia is GNAS (GNAS complex locus), and among its related pathways are Colorectal cancer and Breast Cancer Regulation by Stathmin1. The compounds titanium and phosphorus have been mentioned in the context of this disorder. Affiliated tissues include bone marrow and t cells, and related mouse phenotypes are endocrine/exocrine gland and craniofacial.

Disease Ontology: A bone remodeling disease that results in the destruction of normal bone and replacing it with fibrous bone tissue.⁶

Wikipedia: Fibrous dysplasia is an abnormal bone growth where normal bone is replaced with fibrous bone tissue....⁴⁴ more...

fibrous dysplasia 6 30 8 32 43 fibrous dysplasia of bone 30

Diseases related to fibrous dysplasia by text searches and GeneDecks gene sharing:

(show top 50)    (show all 560)

id	Related Disease	Score	Top Affiliating Genes
1	mccune albright syndrome	35.4	APC, GNAS, GH1, PRL
2	osteofibrous dysplasia	30.5	BGLAP, CD36, FOS, GNAS, SPP1, SPARC
3	ossifying fibroma	29.4	BGLAP, GNAS, RUNX2
4	primary hyperparathyroidism	27.7	BGLAP, CD36, FGF23, IBSP, ALPP, CALCA
5	acromegaly	26.9	BGLAP, CD36, IL6, APC, GNAS, CALCA
6	nephritis	26.7	UMOD, CD36, IL6, APOH, SPP1, NPHP1
7	hyperprolactinemia	26.0	BGLAP, IL6, GNAS, GH1, GHRH, TP53
8	hyperparathyroidism	24.0	BGLAP, CD36, FGF23, IL6, IBSP, ALPL
9	cerebritis	21.0	MYC, BGLAP, CD36, CDKN2A, FOS, IL6
10	osteosarcoma	19.9	MYC, BGLAP, CD36, CDKN2A, FOS, AR
11	tsh producing pituitary tumor	13.7	GH1, PRL
12	chromophobe adenoma	13.7	GH1, PRL
13	x-linked hypophosphatemia	13.7	BGLAP, FGF23, GH1
14	albright's hereditary osteodystrophy	13.7	APC, GNAS, ADCY10
15	laron dwarfism	13.7	GH1, GHR
16	craniofacial anomalies	13.6	MSX2, GNAS, RUNX2
17	pseudohypoparathyroidism type ia	13.6	APC, GNAS, GH1, PRL
18	fetal adenoma	13.6	GH1, GHRH, PRL
19	saethre-chotzen syndrome	13.6	BGLAP, MSX2, RUNX2
20	growth disorders	13.6	GH1, GHR, GHRH
21	carney complex	13.6	GNAS, GH1, PRL
22	fibrodysplasia ossificans progressiva	13.6	MSX2, FOS, GNAS
23	pseudohypoparathyroidism type 1b	13.6	GNAS, PTHLH
24	turner syndrome	13.6	BGLAP, GH1, GHR
25	pituitary hypoplasia	13.6	GH1, GHRH, PRL
26	pseudohypoparathyroidism type ib	13.5	BGLAP, GNAS, PTHLH
27	pituitary gland disease	13.5	GH1, PRL
28	hypophosphatasia	13.5	ALPL, ALPP
29	thyroid adenoma	13.5	BGLAP, APC, GNAS, ADCY10
30	infectious mononucleosis	13.5	BGLAP, ALPL, RUNX2
31	petrositis	13.5	GH1, PTHLH, PRL
32	delayed puberty	13.5	GHR, GHRH, PRL
33	aortic valve stenosis	13.5	IBSP, SPP1, SPARC
34	cerebellar hypoplasia	13.5	GNAS, GH1, GHRH, RUNX2
35	paget's disease of bone	13.5	BGLAP, CALCA
36	idiopathic juvenile osteoporosis	13.5	BGLAP, CALCA, GH1
37	dentin dysplasia	13.5	MSX2, IBSP, SPP1
38	common bile duct disease	13.5	ALPL, ALPP, ALPPL2
39	familial male-limited precocious puberty	13.5	APC, GNAS, GH1, GHR, PRL
40	cleidocranial dysplasia	13.5	BGLAP, MSX2, ALPL, RUNX2
41	germinoma	13.5	APC, ALPP, PRL
42	dysgerminoma of ovary	13.4	ALPP, PTHLH
43	brachydactyly type e	13.4	APC, PTHLH
44	thyroid cancer, follicular	13.4	FOS, CALCA, ADCY10
45	testicular neoplasm	13.4	ALPL, ALPP, ALPPL2
46	humoral hypercalcemia of malignancy	13.4	BGLAP, FGF23, PTHLH, ADCY10
47	chst3-related skeletal dysplasia	13.4	GNAS, PTHLH, RUNX2
48	pituitary-dependent cushing's disease	13.4	GH1, SST, PRL
49	thyroid cancer	13.4	APC, CALCA, ADCY10
50	acrodermatitis enteropathica	13.4	ALPL, ALPP, ALPPL2

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to fibrous dysplasia:

²²

MGI Mouse Phenotypes related to fibrous dysplasia:

²⁵ (show all 27)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	endocrine/exocrine gland phenotype	MP:0005379	9.7	MSX2, GNA11, GNAS, GHR, GHRH, POSTN
2	craniofacial phenotype	MP:0005382	9.6	RUNX2, POSTN, GNAS, GNA11, ALPL, MSX2
3	respiratory system phenotype	MP:0005388	9.5	RUNX2, CALCA, GNA11, ALPL, FGF23
4	limbs/digits/tail phenotype	MP:0005371	9.1	RUNX2, POSTN, PTHLH, GHR, GNAS, GNA11
5	hematopoietic system phenotype	MP:0005397	8.9	RUNX2, PRKG1, SPARC, PTHLH, GNA11, ALPL
6	embryogenesis phenotype	MP:0005380	8.8	PRL, ALPP, ALPL, APC, FOS, MSX2
7	hearing/vestibular/ear phenotype	MP:0005377	8.8	GNAS, GNA11, APC, FOS, MSX2, MYC
8	renal/urinary system phenotype	MP:0005367	8.5	NPHP1, PRKG1, PTHLH, GHR, GNAS, GNA11
9	pigmentation phenotype	MP:0001186	8.1	TP53, GNA11, APC, CDKN2A, MSX2, MYC
10	integument phenotype	MP:0010771	8.1	RUNX2, PRL, PTHLH, TP53, CALCA, GNAS
11	liver/biliary system phenotype	MP:0005370	7.6	GHRH, TP53, NR1H2, PRL, GHR, GH1
12	normal phenotype	MP:0002873	7.4	PRKG1, NR1H2, SST, GNAS, GNA15, GNA11
13	vision/eye phenotype	MP:0005391	7.2	TP53, PTHLH, SPARC, NPHP1, RUNX2, APC
14	nervous system phenotype	MP:0003631	7.1	PTHLH, SPP1, NR1H2, PRKG1, PRL, RUNX2
15	immune system phenotype	MP:0005387	7.0	GNAS, GHR, TP53, PTHLH, SPARC, PRKG1
16	reproductive system phenotype	MP:0005389	6.9	MSX2, PRL, POSTN, NPHP1, ADCY10, PRKG1
17	tumorigenesis	MP:0002006	6.9	POSTN, PRL, SPARC, SPP1, TP53, APC
18	adipose tissue phenotype	MP:0005375	6.9	PTHLH, TP53, GHR, GH1, GNAS, ALPL
19	behavior/neurological phenotype	MP:0005386	6.8	PTHLH, SST, SPP1, SPARC, PRKG1, PRL
20	mortality/aging	MP:0010768	6.7	GNA11, GNAS, GHR, TP53, PRKG1, RUNX2
21	cellular phenotype	MP:0005384	5.5	TP53, PTHLH, SPP1, NR1H2, POSTN, RUNX2
22	digestive/alimentary phenotype	MP:0005381	5.5	ALPL, TP53, PTHLH, SST, PRKG1, RUNX2
23	muscle phenotype	MP:0005369	5.4	GNAS, TP53, SPP1, NR1H2, PRKG1, POSTN
24	skeleton phenotype	MP:0005390	5.3	MYC, UMOD, MSX2, CDKN2A, FOS, AR
25	cardiovascular system phenotype	MP:0005385	4.7	GHR, TP53, PTHLH, SPP1, NR1H2, PRKG1
26	growth/size phenotype	MP:0005378	4.1	GNA11, GNAS, GH1, GHR, GHRH, TP53
27	homeostasis/metabolism phenotype	MP:0005376	3.0	MYC, GNAS, CALCA, GH1, GHR, GHRH

Articles related to fibrous dysplasia:

(show all 44)

id	Title	Authors	Year	Affiliating Genes
1	Expression and regulation of amphiregulin in GsI+-muta ted human bone marrow stromal cells of fibrous dysplasia of mandible. (21439861)	Jia S.... Li S.	2011	AREG
2	Potent constitutive cyclic AMP-generating activity of XLI+s implicates this imprinted GNAS product in the pathogenesis of McCune-Albr ight syndrome and fibrous dysplasia of bone. (20887824)	Mariot V.... Bastepe M.	2011	GNAS
3	Periostin, a novel marker of intramembranous ossification, is expressed in fibrous dysplasia and in c-Fos-overexpressing bone lesions. (18799196)	Kashima T.G.... Kudo A.	2009	POSTN
4	Fibrous dysplasia of bone in a young male (19627736)	Alonso G.... MuA+oz-Torres M.	2009	GNAS
5	Abnormal expression of c-myc, p53, p16 protein and G NAS1 gene mutation in fibrous dysplasia (19575869)	Tang J.... Jiang Z.M.	2009	TP53, MYC, GNAS
6	Clonal status of fibrous dysplasia. (18446630)	Gong L.... Su Q.	2008	AR, PRKG1
7	Nephronophthisis-like nephritis associated with fibrous dysplasia of bone. (18512082)	Bacchetta J.... Cochat P.	2008	UMOD, NPHP1
8	Age-dependent demise of GNAS-mutated skeletal stem cells and 'normalization' of fibrous dysplasia of bone. (18597624)	Kuznetsov S.A.... Bianco P.	2008	GNAS
9	A sensitive mutation-specific screening technique for GNAS1 mutations in cases of fibrous dysplasia: the first report of a codon 227 mutation in bone. (17493233)	Idowu B.D.... Flanagan A.M.	2007	GNAS
10	Ossifying fibroma vs fibrous dysplasia of the jaw: molecular and immunological characterization. (17334331)	Toyosawa S.... Tomita Y.	2007	RUNX2, BGLAP
11	The pathology of fibrous dysplasia and the McCune-Alb right syndrome. (17982387)	Riminucci M.... Bianco P.	2007	GNAS
12	Fibrous dysplasia: molecular clonality analysis of 21 cases (18070446)	Gong L.... Su Q.	2007	AR, PRKG1
13	McCune-Albright syndrome with acromegaly and fibrous dysplasia associated with the GNAS gene mutation identified by sensitive PNA-clamping method. (17878646)	Imanaka M.... Chihara K.	2007	GNAS
14	Current approach to fibrous dysplasia of bone and McC une-Albright syndrome. (19308500)	Leet A.I.... Collins M.T.	2007	GNAS
15	Fibrous dysplasia, phosphate wasting and fibroblast growth factor 23. (17982392)	Imel E.A.... Econs M.J.	2007	FGF23
16	Expression of FGF23 is correlated with serum phosphate level in isolated fibrous dysplasia. (16337659)	Kobayashi K.... Nishizawa Y.	2006	GNAS, FGF23
17	Fibrous dysplasia. Pathophysiology, evaluation, and t reatment. (16085630)	DiCaprio M.R.... Enneking W.F.	2005	GNAS
18	A highly sensitive polymerase chain reaction method detects activating mutations of the GNAS gene in peripheral blood cells in McCune-Albright syndrome or isolated fibrous dysplasia. (16264125)	Lietman S.A.... Levine M.A.	2005	GNAS
19	A novel technique based on a PNA hybridization probe and FRET principle for quantification of mutant genotype in fibrous dysplasia/McCune-Albright syndrome. (15096559)	Karadag A.... Fisher L.W.	2004	GNAS
20	Investigation of the GSalpha gene in the diagnosis of fibrous dysplasia. (15183415)	PerdigALo P.F.... Gomez R.S.	2004	GNAS
21	Dental characteristics of fibrous dysplasia and McCune-Albright syndrome. (12973283)	Akintoye S.O.... Collins M.T.	2003	GNAS
22	Osteoclastogenesis in fibrous dysplasia of bone: in situ and in vitro analysis of IL-6 expression. (13678786)	Riminucci M.... Gehron Robey P.	2003	IL6, GNAS
23	FGF-23 in fibrous dysplasia of bone and its relationship to renal phosphate wasting. (12952917)	Riminucci M.... Gehron Robey P.	2003	GNAS, FGF23
24	Osteomalacic and hyperparathyroid changes in fibrous dysplasia of bone: core biopsy studies and clinical correlations. (12854833)	Corsi A.... Bianco P.	2003	GNAS
25	Is McCune-Albright syndrome overlooked in subjects with fibrous dysplasia of bone? (12756386)	Hannon T.S.... Pescovitz O.H.	2003	GNAS
26	Bone turnover in children and adolescents with McCune-Albright syndrome treated with pamidronate for bone fibrous dysplasia. (12200645)	Isaia G.C.... De Sanctis C.	2002	ALPP
27	Melatonin deficiency and fibrous dysplasia: might a relation exist? (12376077)	Abdel-Wanis M.E.... Tsuchiya H.	2002	GNAS, NR1H2, IBSP
28	Gsalpha gene mutations in monostotic fibrous dysplasi a of bone and fibrous dysplasia-like low-grade central osteosarcoma. (11561757)	Pollandt K.... Delling G.	2001	GNAS
29	A comparative study of fibrous dysplasia and osteofibrous dysplasia with regard to Gsalpha mutation at the Arg201 codon: polymerase chain reaction-restriction fragment length polymorphism analysis of paraffin-embedded tissues. (11272890)	Sakamoto A.... Tsuneyoshi M.	2000	GNAS
30	Mutations of the GNAS1 gene, stromal cell dysfunction, and osteomalacic changes in non-McCune-Albright fibrous dysplasia of bone. (10646121)	Bianco P.... Robey P.G.	2000	APC, GNAS
31	Parathyroid hormone-related protein in the aetiology of fibrous dysplasia of bone in the McCune Albright syndrome. (11106924)	Fraser W.D.... Gallagher J.A.	2000	PTHLH
32	Familial craniofacial fibrous dysplasia: absence of linkage to GNAS1 and the gene for cherubism. (11073546)	Mangion J.... Flanagan A.M.	2000	GNAS
33	Etiology of fibrous dysplasia and McCune-Albright syndrome. (10535539)	Cohen M.M.... Howell R.E.	1999	GNAS
34	A rare case of polyostotic fibrous dysplasia assessed by bone scintigraphy with Tc-99m methylene diphosphonate (MDP). (10488486)	Di Leo C.... Tarolo G.L.	1999	BGLAP
35	A comparative study of fibrous dysplasia and osteofibrous dysplasia with regard to expressions of c-fos and c-jun products and bone matrix proteins: a clinicopathologic review and immunohistochemical study of c-fos, c-jun, type I collagen, osteonectin, osteopontin, and osteocalcin. (10667418)	Sakamoto A.... Tsuneyoshi M.	1999	SPP1, FOS, SPARC
36	Fibrous dysplasia. The clinico-therapeutic picture and new data on its etiology. A review of the literature (9578646)	Mandrioli S.... Calura G.	1998	FOS
37	Fibrous dysplasia of bone in the McCune-Albright syndrome: abnormalities in bone formation. (9403710)	Riminucci M.... Gehron Robey P.	1997	SPARC, IBSP
38	Primary hyperparathyroidism-associated polyostotic fibrous dysplasia: absence of McCune-Albright syndrome mutations. (9413810)	Hammami M.M.... Hussain S.S.	1997	GNAS
39	Polymerase chain reaction-based technique for the selective enrichment and analysis of mosaic arg201 mutations in G alpha s from patients with fibrous dysplasia of bone. (9267696)	Candeliere G.A.... Glorieux F.H.	1997	GNAS
40	Increased expression of the c-fos proto-oncogene in bone from patients with fibrous dysplasia. (7739708)	Candeliere G.A.... St-Arnaud R.	1995	FOS, GNAS, ADCY10
41	Acromegaly and hyperprolactinemia in a patient with polyostotic fibrous dysplasia: dynamic endocrine studies and treatment with the somatostatin analogue octreotide. (7911814)	Garcia M.B.... Krenning E.P.	1994	PRL, SST, GH1
42	Fibrous dysplasia of the temporal bone and cerebral occlusive vasculopathy: report of a case (1308396)	Inamorato E.... Zukerman E.	1992	APOH
43	Paget's disease and fibrous dysplasia. (1883702)	Wallach S.	1991	CALCA
44	A case of fibrous dysplasia (McCune Albright syndrome) associated with acromegaly (2070893)	Chiba Y.... Tamura T.	1991	PRL, GH1

Genes related to fibrous dysplasia according to GeneCards:

(show all 36)

id	Symbol	Description	Score	GeneCards Section Context
1	GNAS	GNAS complex locus	11.1	Publications, Summaries
2	APC	adenomatous polyposis coli	11.0	Publications
3	GH1	growth hormone 1	11.0	Publications
4	IBSP	integrin-binding sialoprotein	11.0	Publications
5	SPARC	secreted protein, acidic, cysteine-rich (osteonectin)	11.0	Publications
6	FGF23	fibroblast growth factor 23	11.0	Publications
7	MSX2	msh homeobox 2	11.0
8	BGLAP	bone gamma-carboxyglutamate (gla) protein	11.0	Publications
9	RUNX2	runt-related transcription factor 2	11.0	Publications
10	FOS	FBJ murine osteosarcoma viral oncogene homolog	11.0	Publications
11	PRL	prolactin	11.0	Publications
12	GHR	growth hormone receptor	11.0
13	ADCY10	adenylate cyclase 10 (soluble)	11.0	Publications
14	POSTN	periostin, osteoblast specific factor	11.0	Publications
15	ALPPL2	alkaline phosphatase, placental-like 2	11.0
16	NPHP1	nephronophthisis 1 (juvenile)	11.0	Publications
17	UMOD	uromodulin	11.0	Publications
18	GNA15	guanine nucleotide binding protein (G protein), alpha 15 (Gq class)	11.0
19	GNA11	guanine nucleotide binding protein (G protein), alpha 11 (Gq class)	11.0
20	AREG	amphiregulin	11.0	Publications
21	GHRH	growth hormone releasing hormone	11.0	Publications
22	ALPL	alkaline phosphatase, liver/bone/kidney	11.0
23	ALPP	alkaline phosphatase, placental	11.0	Publications
24	APOH	apolipoprotein H (beta-2-glycoprotein I)	11.0	Publications
25	PTHLH	parathyroid hormone-like hormone	11.0	Publications
26	NR1H2	nuclear receptor subfamily 1, group H, member 2	11.0	Publications
27	SPP1	secreted phosphoprotein 1	11.0	Publications
28	CD36	CD36 molecule (thrombospondin receptor)	11.0	Publications
29	CALCA	calcitonin-related polypeptide alpha	11.0	Publications
30	AR	androgen receptor	11.0	Publications
31	SST	somatostatin	11.0	Publications
32	CDKN2A	cyclin-dependent kinase inhibitor 2A	11.0	Publications
33	PRKG1	protein kinase, cGMP-dependent, type I	11.0	Publications
34	MYC	v-myc myelocytomatosis viral oncogene homolog (avian)	11.0	Publications
35	IL6	interleukin 6 (interferon, beta 2)	11.0	Publications
36	TP53	tumor protein p53	11.0	Publications

Pathways related to fibrous dysplasia according to GeneDecks:

(show top 50)    (show all 71)

id	Pathway	Score	Top Affiliating Genes
1	Colorectal cancer20	10.4	FOS
2	Breast Cancer Regulation by Stathmin136	10.1	GHRH, GNA15, GNA11, FGF23
3	Folate biosynthesis20	10.0	ALPL, ALPP, ALPPL2
4	ILK Signaling36	10.0	GHRH, GH1, FGF23, AREG, FOS
5	14-3-3 Induced Intracellular Signaling36	10.0	GHRH, GH1, FGF23, AREG
6	Platelet Aggregation Inhibitor Pathway, Pharmacodynamics34	9.9	GNAS, GNA15, GNA11, CD36
7	Ras Pathway36	9.9	GHRH, FGF23, AREG, FOS
8	Class B/2 (Secretin family receptors)38	9.8	PTHLH, GHRH, CALCA, GNAS
9	Actin-Based Motility by Rho Family GTPases36	9.8	GHRH, GH1, GNA15, GNA11, FGF23, AREG
10	Glioma Invasiveness36	9.8	AREG, FGF23, GH1, GHRH
11	CREB Pathway36	9.7	GHRH, GH1, GNA15, GNA11, FGF23, AREG
12	PTEN Pathway36	9.6	TP53, GHRH, GH1, FGF23, AREG
13	Akt Signaling36	9.5	FGF23, IL6, GNA11, GNA15
14	Development_Hedgehog and PTH signaling pathways in bone and cartilage development41	9.5	BGLAP, RUNX2, SPP1, PTHLH, GNAS, GNA11
15	Development Hedgehog and PTH signaling pathways in bone and cartilage development10	9.5	RUNX2, SPP1, PTHLH, GNAS, GNA11, IBSP
16	Jak-STAT signaling pathway20	9.3	PRL, GHR, GH1, MYC
17	Chagas disease (American trypanosomiasis)20	9.3	GNAS, GNA15, GNA11, IL6, FOS
18	Nanog in Mammalian ESC Pluripotency36	9.1	GHRH, GH1, APC, IL6, FGF23, AREG
19	Pathways in cancer20	9.1	TP53, FGF23, AR, FOS, MYC
20	Telomerase Components in Cell Signaling36	9.1	TP53, GHRH, GH1, FGF23, AREG, MYC
21	Renin-Angiotensin Pathway36	9.0	GHRH, GH1, GNA11, IL6, FGF23, AREG
22	TGF-Beta Pathway36	9.0	GHRH, GH1, IL6, FGF23, AREG, FOS
23	p70S6K Signaling36	9.0	GHRH, GH1, GNA15, GNA11, IL6, FGF23
24	IP3 Pathway36	9.0	GHRH, GH1, GNA15, GNA11, IL6, FGF23
25	Activation of PKC through GPCR36	9.0	GHRH, GH1, GNA15, GNA11, IL6, FGF23
26	Rap1 Pathway36	8.9	GHRH, GH1, GNA15, GNA11, IL6, FGF23
27	NFAT in Immune Response36	8.9	GHRH, GH1, GNA15, GNA11, IL6, FGF23
28	MAPK Family Pathway36	8.9	GHRH, GH1, GNA15, GNA11, IL6, FGF23
29	Estrogen Pathway36	8.9	GHRH, GH1, GNA15, GNA11, IL6, FGF23
30	GPCR Pathway36	8.9	GHRH, GH1, GNA15, GNA11, IL6, FGF23
31	Tec Kinases Signaling36	8.8	GHRH, GH1, GNA15, GNA11, IL6, FGF23
32	Apoptotic Pathways in Synovial Fibroblasts36	8.8	TP53, GHRH, GH1, IL6, FGF23, AREG
33	Activation of PKA through GPCR36	8.8	GHRH, GH1, GNA15, GNA11, IL6, FGF23
34	Intracellular Calcium Signaling36	8.8	GHRH, GH1, GNA15, GNA11, IL6, FGF23
35	p53 Mediated Apoptosis36	8.8	TP53, GHRH, GH1, IL6, FGF23, AREG
36	Transcription_Role of VDR in regulation of genes involved in osteoporosis41	8.7	RUNX2, SPP1, CALCA, IL6, AR, FOS
37	Transcription Role of VDR in regulation of genes involved in osteoporosis10	8.7	RUNX2, SPP1, CALCA, IL6, AR, FOS
38	Phospholipase-C Pathway36	8.6	SPP1, GHRH, GH1, GNA15, GNA11, IL6
39	Inhibition of Ribosome Biogenesis by p14(ARF)36	8.6	MYC, CDKN2A, TP53
40	Rho Family GTPases36	8.5	SPP1, GHRH, GH1, GNA15, GNA11, IL6
41	eNOS Signaling36	8.5	PRKG1, GHRH, GH1, IL6, FGF23, AREG
42	Mitochondrial Apoptosis36	8.4	TP53, GHRH, GH1, IL6, FGF23, AREG
43	Cellular Apoptosis Pathway36	8.4	TP53, GHRH, GH1, IL6, FGF23, AREG
44	p38 Signaling36	8.4	TP53, GHRH, GH1, GNA15, GNA11, IL6
45	Pancreatic Adenocarcinoma36	8.4	TP53, GHRH, GH1, IL6, FGF23, AREG
46	JAK-STAT Pathway36	8.3	PRL, GHRH, GHR, GH1, IL6, FGF23
47	ERK5 Signaling36	8.3	GHRH, GH1, GNA15, GNA11, IL6, FGF23
48	MAPK Signaling36	7.4	SPP1, TP53, GHRH, GH1, GNA15, GNA11
49	ERK Signaling36	7.4	GH1, GHRH, TP53, SPP1, GNA15, GNA11
50	Molecular Mechanisms of Cancer36	6.9	GNA15, GH1, GHRH, TP53, SPP1, GNA11

Compounds related to fibrous dysplasia according to GeneDecks:

(show top 50)    (show all 200)

id	Compound	Score	Top Affiliating Genes
1	titanium32	9.7	SPARC, ALPP, RUNX2, CD36, BGLAP, IBSP
2	phosphorus32	9.7	ALPP, FGF23, SPP1, CALCA
3	gnrh32	9.6	AR, NR1H2, GHRH, GHR, GNAS, GH1
4	glucose32	9.5	APC, PTHLH, PRKG1, RUNX2, UMOD, SPARC
5	ghrp32	9.4	GH1, GHR, GHRH, SST, PRL
6	alizarin32	9.3	ALPL, ALPP, SPP1, SPARC, RUNX2, IBSP
7	pyridinoline32	9.2	BGLAP, CD36, IBSP, ALPP, CALCA, GH1
8	alendronate32 9 9	11.2	BGLAP, CD36, ALPP, CALCA, GH1, PTHLH
9	procollagen32	9.2	ALPP, CD36, GH1, GHR, SPP1, IBSP
10	clonidine32 9 9	11.1	CALCA, GHR, ADCY10, GH1, GHRH, PRL
11	isoproterenol32 9 9	11.1	AR, GNAS, GH1, PTHLH, SST, ADCY10
12	calcium carbonate32	9.1	PTHLH, CALCA, ALPP, CD36, BGLAP
13	hydroxyproline32 18	10.0	BGLAP, CD36, ALPP, IBSP, CALCA, PTHLH
14	25-hydroxyvitamin d32	9.0	SPP1, FGF23, BGLAP, CALCA, CD36, ALPP
15	deoxypyridinoline32	8.9	ALPP, BGLAP, GH1, CALCA, CD36, IBSP
16	creatinine32	8.9	PTHLH, UMOD, CDKN2A, FGF23, APOH, IBSP
17	octreotide32 42 9 9	11.8	FGF23, GNAS, CALCA, GH1, GHR, GHRH
18	pge232	8.8	SST, SPP1, SPARC, NR1H2, RUNX2, ADCY10
19	hydroxyapatite32	8.7	BGLAP, UMOD, CD36, SPARC, RUNX2, ALPL
20	dopamine32 9 18 9	11.7	FOS, CDKN2A, APC, GNAS, GH1, GHRH
21	pamidronate32 9 9	10.6	BGLAP, PTHLH, CD36, ALPP, IL6, CALCA
22	progesterone32 42 9 18 9	12.6	PTHLH, AREG, AR, APC, GNAS, GH1
23	ibmx32	8.5	CALCA, NR1H2, ALPP, SST, PTHLH, GH1
24	heparin32 9 18 9	11.5	ALPP, PTHLH, SPP1, SPARC, IBSP, NR1H2
25	zoledronic acid32	8.5	IL6, CD36, PTHLH, BGLAP, CALCA, ALPP
26	ribonucleic acid32	8.4	PRL, GHRH, GHR, GH1, GNAS, FOS
27	thyroxine32 18	9.4	BGLAP, FOS, ALPP, CALCA, GH1, GHR
28	cyclic amp32 18	9.2	CALCA, GHRH, ADCY10, RUNX2, CDKN2A, FOS
29	1,25 dihydroxy vitamin d332	8.2	BGLAP, FGF23, IBSP, ALPP, CALCA, GH1
30	steroid32	8.1	NR1H2, AREG, SPARC, PTHLH, GHRH, GHR
31	acth32	8.1	PRL, SST, GHRH, GHR, CALCA, GNAS
32	arginine32	7.8	GNAS, SST, ADCY10, ALPP, APOH, FGF23
33	hydrocortisone32 9 9	9.8	NR1H2, CALCA, SST, PTHLH, GH1, ALPP
34	sb 20358032 42	8.7	SPP1, BGLAP, CD36, FOS, AREG, IL6
35	norepinephrine32 9 18 9	10.6	APC, GNAS, CALCA, AREG, GH1, IL6
36	tamoxifen32 34 9 9	10.6	FOS, BGLAP, TP53, GHRH, NR1H2, GH1
37	oligonucleotide32	7.3	AREG, MYC, GHR, CDKN2A, GH1, GNAS
38	estrogen32	7.2	ALPP, IBSP, APOH, APC, AR, CD36
39	paraffin32	6.9	TP53, GHR, GH1, ALPPL2, ALPP, IBSP
40	calcium32 9 18 9	9.9	MSX2, UMOD, BGLAP, SPARC, PRKG1, CD36
41	testosterone32 9 18 9	9.8	GHR, PRL, PRKG1, NR1H2, SPARC, SPP1
42	thymidine32 18	7.8	RUNX2, PRKG1, SPARC, PTHLH, GNAS, GHR
43	vitamin d32	6.5	BGLAP, CD36, AR, FGF23, RUNX2, NR1H2
44	genistein32 9 18 9	9.5	ADCY10, FOS, AR, IL6, ALPP, SPP1
45	calcitriol32 42 9 18 9	10.3	GH1, CALCA, ALPP, IL6, FGF23, AR
46	serine32	5.4	AR, FGF23, APC, IBSP, ALPP, RUNX2
47	cycloheximide32	5.2	TP53, PTHLH, SST, SPP1, RUNX2, ADCY10
48	dexamethasone32 42 34 9 9	9.1	MYC, BGLAP, CD36, CDKN2A, FOS, AREG
49	retinoic acid32 42 18	6.9	AREG, FOS, CDKN2A, CD36, BGLAP, MYC
50	vegf32	4.0	PRKG1, CDKN2A, CD36, BGLAP, MYC, FOS

Cellular components related to fibrous dysplasia according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	membrane-bounded vesicle	GO:031988	9.9	BGLAP, IBSP, SPP1
2	anchored to membrane	GO:031225	9.6	UMOD, ALPL, ALPP, ALPPL2
3	neuronal cell body	GO:043025	9.0	ADCY10, SST, GHR, CALCA, APC
4	nuclear body	GO:016604	8.8	TP53, CDKN2A, MYC
5	extracellular region	GO:005576	7.1	GHRH, PTHLH, SST, SPP1, SPARC, PRL
6	extracellular space	GO:005615	6.8	BGLAP, SPARC, SPP1, SST, PTHLH, GHRH

Biological processes related to fibrous dysplasia according to GeneDecks:

(show all 18)

id	Name	GO ID	Score	Top Affiliating Genes
1	osteoblast differentiation	GO:001649	10.4	RUNX2, MSX2, BGLAP
2	osteoblast development	GO:002076	10.2	BGLAP, MSX2, PTHLH
3	JAK-STAT cascade involved in growth hormone signaling pathway	GO:060397	10.1	PRL, GHR, GH1
4	positive regulation of insulin-like growth factor receptor signaling pathway	GO:043568	10.0	AR, GH1, GHRH
5	response to vitamin D	GO:033280	10.0	SPP1, ALPL, BGLAP
6	positive regulation of multicellular organism growth	GO:040018	9.9	GHRH, GHR, GH1
7	skeletal system development	GO:001501	9.7	POSTN, PTHLH, GNA11, ALPL, BGLAP
8	positive regulation of JAK-STAT cascade	GO:046427	9.6	PRL, GH1, IL6
9	chromosome organization	GO:051276	9.4	MYC, APC, TP53
10	positive regulation of tyrosine phosphorylation of Stat3 protein	GO:042517	9.4	GHR, GH1, IL6
11	positive regulation of cAMP biosynthetic process	GO:030819	9.3	PTHLH, GHRH, CALCA
12	response to glucocorticoid stimulus	GO:051384	9.3	BGLAP, IL6, ALPL, GHR, SPARC
13	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	8.8	TP53, GHR, GH1, IL6, CD36
14	platelet activation	GO:030168	8.8	CD36, IL6, GNA11, GNA15, SPARC
15	blood coagulation	GO:007596	8.6	PRKG1, SPARC, TP53, GNAS, GNA15, GNA11
16	negative regulation of apoptotic process	GO:043066	8.1	TP53, APC, IL6, AR, MSX2, MYC
17	negative regulation of cell proliferation	GO:008285	7.9	SST, PTHLH, TP53, APC, IL6, CDKN2A
18	positive regulation of transcription, DNA-dependent	GO:045893	7.4	MYC, RUNX2, TP53, GHRH, IL6, FGF23

Molecular functions related to fibrous dysplasia according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	prolactin receptor binding	GO:005148	10.2	GH1, PRL
2	alkaline phosphatase activity	GO:004035	9.7	ALPL, ALPP, ALPPL2
3	hormone activity	GO:005179	8.9	PRL, SST, PTHLH, GH1, CALCA