MCID: FBR009
MIFTS: 50

Fibrous Dysplasia malady

Rare diseases, Bone diseases categories

Summaries for Fibrous Dysplasia

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NIH Rare Diseases:42 Fibrous dysplasia is a progressive bone disorder that is characterized by the replacement of normal bone with weaker tissues, such as fibrous tissue and woven bone.  it may involve one bone (monostotic) or multiple bones (polyostotic).  though many individuals with this condition do not have any symptoms, others may have bone pain, abnormally shaped bones, or an increased risk of breaking bones.  this condition can occur alone or as part of a genetic disorder, such as mccune-albright syndrome. last updated: 8/25/2011

MalaCards based summary: Fibrous Dysplasia, also known as fibrous dysplasia of bone, is related to mccune albright syndrome and gigantism. An important gene associated with Fibrous Dysplasia is GNAS (GNAS complex locus), and among its related pathways are Interleukin-11 Signaling Pathway and Osteoblast Signaling. The compounds pyridinoline and pphp have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and lung, and related mouse phenotypes are adipose tissue and hearing/vestibular/ear.

Disease Ontology:9 A bone remodeling disease that results in the destruction of normal bone and replacing it with fibrous bone tissue.

Wikipedia:64 Fibrous dysplasia is an abnormal bone growth where normal bone is replaced with fibrous bone tissue.... more...

Aliases & Classifications for Fibrous Dysplasia

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Fibrous Dysplasia, Aliases & Descriptions:

Name: Fibrous Dysplasia 9 42 11 44 61
 
Fibrous Dysplasia of Bone 42 61


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Bone diseases


External Ids:

Disease Ontology9 DOID:0080031

Related Diseases for Fibrous Dysplasia

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Diseases related to Fibrous Dysplasia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 139)
idRelated DiseaseScoreTop Affiliating Genes
1mccune albright syndrome31.8FGF23, GNAS
2gigantism31.1GH1, GNAS
3osteofibrous dysplasia30.9BGLAP, GNAS
4hyperprolactinemia30.7GNAS, GH1
5hyperparathyroidism30.6FGF23, BGLAP
6acromegaly30.5BGLAP, GNAS, APC, GH1
7osteogenesis imperfecta30.5IBSP, BGLAP
8precocious puberty30.4GH1, APC, GNAS
9prolactinoma30.4GH1, GNAS
10goiter30.3BGLAP, GNAS
11primary hyperparathyroidism30.3BGLAP, IBSP, FGF23
12osteomalacia30.2FGF23, GNAS, BGLAP
13hypophosphatemia30.2FGF23, BGLAP
14giant cell tumor30.2BGLAP, FGF23
15pituitary adenoma30.2GNAS, APC, GH1
16rickets30.2FGF23, BGLAP
17hypercalcemia30.1BGLAP, FGF23
18adenoma30.0GH1, APC, GNAS
19hyperthyroidism29.8BGLAP, GNAS, GH1, FGF23
20prostate cancer29.7BGLAP, IBSP, GNAS, APC
21osteoporosis29.7FGF23, GH1, IBSP, BGLAP
22breast cancer29.3IBSP, APC, MSX2, GH1
23monostotic fibrous dysplasia11.1
24fibroma10.6
25ossifying fibroma10.6
26aneurysmal bone cysts10.6
27aneurysm10.6
28cherubism10.5
29cervicitis10.5
30osteosarcoma10.5
31acrodysostosis10.5GNAS
32panostotic fibrous dysplasia10.4
33sinusitis10.4
34sarcoma10.4
35meningioma10.3
36pseudohypoparathyroidism type 1b10.3GNAS, BGLAP
37osteitis fibrosa10.3BGLAP, GNAS
38progressive osseous heteroplasia10.3BGLAP, GNAS
39idiopathic juvenile osteoporosis10.3GH1, BGLAP
40blindness10.2
41mazabraud syndrome10.2
42gastrinoma10.2APC, GH1
43thyroid adenoma10.2GNAS, APC
44hyperandrogenism10.2GNAS, GH1
45adrenal gland hyperfunction10.2GH1, BGLAP
46turner syndrome10.2GH1, BGLAP
47growth hormone deficiency10.2GH1, BGLAP
48hyperphosphatemia10.2FGF23, GNAS
49neuroendocrine tumor10.2GH1, GNAS
50osteoporosis, postmenopausal10.2IBSP, BGLAP

Graphical network of the top 20 diseases related to Fibrous Dysplasia:



Diseases related to fibrous dysplasia

Symptoms for Fibrous Dysplasia

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Drugs & Therapeutics for Fibrous Dysplasia

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Drug clinical trials:

Search ClinicalTrials for Fibrous Dysplasia

Search NIH Clinical Center for Fibrous Dysplasia

Genetic Tests for Fibrous Dysplasia

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Anatomical Context for Fibrous Dysplasia

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MalaCards organs/tissues related to Fibrous Dysplasia:

32
Bone, Bone marrow, Lung, Breast, Prostate, Testes, Myeloid, B cells, Pituitary

Animal Models for Fibrous Dysplasia or affiliated genes

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MGI Mouse Phenotypes related to Fibrous Dysplasia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053759.2GH1, APC, GNAS
2MP:00053778.5MSX2, APC, GNAS
3MP:00053798.4GH1, MSX2, APC, GNAS
4MP:00107718.1GNAS, APC, MSX2, FGF23
5MP:00053717.8FGF23, MSX2, APC, GNAS, IBSP
6MP:00053907.7IBSP, GNAS, APC, MSX2, FGF23
7MP:00053787.4IBSP, GNAS, APC, MSX2, GH1, FGF23

Publications for Fibrous Dysplasia

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Articles related to Fibrous Dysplasia:

(show top 50)    (show all 662)
idTitleAuthorsYear
1
Treatment protocols for growth hormone-secreting pituitary adenomas combined with craniofacial fibrous dysplasia: A case report of atypical McCune-Albright syndrome. (25120617)
2014
2
En bloc resection and bone graft: does it alter the natural history of monostotic expansile fibrous dysplasia in children? (25407316)
2014
3
Monostotic fibrous dysplasia of the mandible. (24984642)
2014
4
An unusual case of intraosseous vascular malformation of the maxilla mimicking fibrous dysplasia: a case report and literature review on imaging features of intraosseous vascular anomalies of the jaw. (24940806)
2014
5
Fibrous dysplasia of the craniofacial bones. (23918916)
2013
6
Low-grade central osteosarcoma of distal femur, resembling fibrous dysplasia. (24147271)
2013
7
Fibrous dysplasia and central giant cell granuloma: a report of hybrid lesion with its review and hypotheticated pathogenesis. (23814754)
2013
8
Isolated fibrous dysplasia of the inferior turbinate. (22698592)
2013
9
Real-time image-guided recontouring in the management of craniofacial fibrous dysplasia. (24113350)
2013
10
Clinical guidelines for the management of craniofacial fibrous dysplasia. (22640797)
2012
11
Peritrabecular clefting in fibrous dysplasia of the jaws: an important histopathologic feature for differentiating fibrous dysplasia from central ossifying fibroma. (22986246)
2012
12
CT and MRI of fibrous dysplasia of the spine. (22167510)
2012
13
An extensive hemimelic polyostotic fibrous dysplasia: a case report. (21331571)
2012
14
Resection of the entire first rib for fibrous dysplasia using a combined posterior-transmanubrial approach. (22614525)
2012
15
Long-term efficacy of oral alendronate therapy in an elderly patient with polyostotic fibrous dysplasia: A case report. (22848294)
2011
16
Dedifferentiated adamantinoma associated with fibrous dysplasia. (22000283)
2011
17
Fibrous dysplasia--a 13-year retrospective radiographic analysis in a south Indian population. (21697153)
2011
18
Fibrous dysplasia and aneurysmal bone cyst of the skull base presenting with blindness: a report of a rare locally aggressive example. (21396116)
2011
19
Monofocal maxillary fibrous dysplasia with orbital, nasal and oral obstruction. (19540186)
2010
20
Periostin, a novel marker of intramembranous ossification, is expressed in fibrous dysplasia and in c-Fos-overexpressing bone lesions. (18799196)
2009
21
Secondary aneurysmal bone cyst in fibrous dysplasia of the proximal femur. (19472953)
2009
22
Pain in fibrous dysplasia of bone: age-related changes and the anatomical distribution of skeletal lesions. (17622477)
2008
23
Oral rehabilitation with endosseous implants in a patient with fibrous dysplasia (McCune-Albright syndrome): a case report. (19022142)
2008
24
Attention deficiency hyperactivity disorder and sphenoid bone fibrous dysplasia association in a boy: SPECT/SPECT fusion imaging. (18075425)
2007
25
Concurrent Ewing sarcoma family of tumors and fibrous dysplasia: possible diagnostic pitfall. (17230061)
2007
26
Fibrous dysplasia of the clivus, a case report. (21503248)
2007
27
Craniofacial fibrous dysplasia and hypophysial microadenoma with Hodgkin's lymphoma: unusual involution of an extensive case. (16860225)
2006
28
Surgery for fibrous dysplasia. (17228997)
2006
29
Activating Gs a mutation rarely occurs in musculoskeletal tumors other than fibrous dysplasia. (16619580)
2006
30
Misleading clavicular osteolytic lesion revealing fibrous dysplasia. (16626990)
2006
31
Imaging of Paget's disease and fibrous dysplasia of bone. (17229004)
2006
32
Isolated fibrous dysplasia of the sphenoid sinus. (16405278)
2005
33
Oral pathology quiz # 43. Case number 1. Fibrous dysplasia. (15793915)
2004
34
Aneurysmal bone cyst arising from fibrous dysplasia of the frontal bone (2004:2b). (15162799)
2004
35
Chondroblastoma of the acromion mimicking fibrous dysplasia. (15669467)
2004
36
Polyostotic fibrous dysplasia with auditory impairment and delayed menarche in a Nigerian. (15298467)
2003
37
Natural history and treatment of fibrous dysplasia of bone: a multicenter clinicopathologic study promoted by the European Pediatric Orthopaedic Society. (12703030)
2003
38
Oral bisphosphonates in polyostotic fibrous dysplasia. (14530553)
2003
39
Magnetic resonance imaging and [11C]methyl-L-methionine positron emission tomography of fibrous dysplasia--two case reports. (12206488)
2002
40
Surgical treatment of fibrous dysplasia of the cranio-maxillo-facial area. Review of the literature and personal experience form 1984 to 1999. (12434124)
2002
41
Cellular and molecular biology of fibrous dysplasia]. (11910936)
2001
42
Polymerase chain reaction-based technique for the selective enrichment and analysis of mosaic arg201 mutations in G alpha s from patients with fibrous dysplasia of bone. (9267696)
1997
43
Fibrous dysplasia of bone in the McCune-Albright syndrome: abnormalities in bone formation. (9403710)
1997
44
Residents' corner. Answer to case of the month #12. McCune-Albright syndrome (polyostotic fibrous dysplasia). (1562893)
1992
45
Empty sella syndrome occurring with polyostotic fibrous dysplasia of the midface: report of a case. (3507319)
1987
46
Ehlers-Danlos syndrome with monostotic fibrous dysplasia. (529175)
1979
47
Pseudopseudohypoparathyroidism with fibrous dysplasia. (1119829)
1975
48
Familial polyostotic fibrous dysplasia. (1060033)
1975
49
Effects of calcitonin in metastatic bone carcinoma, osteoporosis, polyostotic fibrous dysplasia and hypercalcemia. (4254451)
1971
50
MONOSTOTIC FIBROUS DYSPLASIA AFFECTING THE SKULL AND FACIAL BONES. (14290332)
1965

Variations for Fibrous Dysplasia

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Expression for genes affiliated with Fibrous Dysplasia

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Expression patterns in normal tissues for genes affiliated with Fibrous Dysplasia

Search GEO for disease gene expression data for Fibrous Dysplasia.

Pathways for genes affiliated with Fibrous Dysplasia

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Compounds for genes affiliated with Fibrous Dysplasia

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Compounds related to Fibrous Dysplasia according to GeneCards/GeneDecks:

(show top 50)    (show all 60)
idCompoundScoreTop Affiliating Genes
1pyridinoline4410.5GH1
2pphp4410.1GNAS, APC
3anastrozole44 50 1211.9BGLAP, GH1
4salbutamol44 50 29 25 1213.9GH1, APC
5alendronate44 50 1211.8BGLAP, GH1
6ibandronate44 1210.8BGLAP, IBSP
7alizarin449.8IBSP, BGLAP
8pertussis449.8APC, GH1
9chitosan449.8BGLAP, IBSP
10sevelamer449.8BGLAP, FGF23
11titanium449.8IBSP, BGLAP
12fluoride449.7GH1, BGLAP
13zoledronic acid449.7BGLAP, IBSP
14raloxifene44 50 29 1212.7BGLAP, GH1
15isoproterenol44 1210.6APC, GH1, GNAS
16acth449.6APC, GH1, GNAS
17clonidine44 50 29 1212.6BGLAP, GH1
18guanine44 25 1211.6GNAS, GH1, APC
1925-hydroxyvitamin d449.6BGLAP, FGF23
20phosphorus449.6FGF23, BGLAP
21norepinephrine44 25 1211.5APC, GNAS, GH1
22gnrh449.5BGLAP, GH1, GNAS
23octreotide44 60 29 1212.5FGF23, GH1, GNAS
24deoxypyridinoline449.5GH1, BGLAP, IBSP
25procollagen449.4IBSP, GH1, BGLAP
26hydroxyproline44 25 1211.4IBSP, BGLAP
27dopamine44 29 25 1212.3APC, GH1, GNAS
28calcitriol44 60 25 1212.3FGF23, GH1, BGLAP
29estradiol44 25 1211.3IBSP, BGLAP, GH1
30hydroxyapatite449.2BGLAP, IBSP, FGF23
31phosphoserine44 2510.2IBSP, APC
32leucine449.2GNAS, IBSP, GH1
33forskolin44 50 1211.1APC, GNAS, IBSP, GH1
34thymidine44 2510.1GH1, IBSP, GNAS
35glutamine449.0GH1, APC, FGF23, GNAS
36pge2449.0BGLAP, APC, GNAS, IBSP
37paraffin449.0BGLAP, IBSP, APC, GH1
38cysteine449.0GNAS, IBSP, BGLAP, GH1
39lipid449.0GH1, APC, GNAS, IBSP
40arginine448.9FGF23, GH1, BGLAP, GNAS
41estrogen448.9APC, GH1, IBSP, BGLAP
421,25 dihydroxy vitamin d3448.9FGF23, BGLAP, IBSP, GH1
43creatinine448.8BGLAP, IBSP, FGF23, GH1
44steroid448.7GNAS, IBSP, GH1, MSX2
45tyrosine448.5IBSP, GNAS, FGF23, APC, GH1
46vitamin d448.4FGF23, BGLAP, GH1, IBSP, APC
47heparin44 29 25 1211.4APC, IBSP, BGLAP, GH1, FGF23
48oligonucleotide448.3IBSP, MSX2, APC, GNAS, GH1
49serine448.0BGLAP, GH1, GNAS, IBSP, APC, FGF23
50calcium44 50 25 1210.6BGLAP, FGF23, MSX2, APC, GNAS, IBSP

GO Terms for genes affiliated with Fibrous Dysplasia

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Cellular components related to Fibrous Dysplasia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.0FGF23, GH1, GNAS, IBSP, BGLAP

Biological processes related to Fibrous Dysplasia according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1regulation of osteoclast differentiationGO:0456709.7APC, BGLAP
2bone developmentGO:0603489.6BGLAP, GNAS
3embryonic hindlimb morphogenesisGO:0351169.4MSX2, GNAS
4osteoblast developmentGO:0020769.3BGLAP, MSX2
5anterior/posterior pattern specificationGO:0099529.2MSX2, APC
6osteoblast differentiationGO:0016499.0BGLAP, MSX2
7positive regulation of osteoblast differentiationGO:0456699.0MSX2, GNAS
8cell adhesionGO:0071559.0APC, IBSP, BGLAP
9cellular response to growth factor stimulusGO:0713638.8MSX2, IBSP, BGLAP

Products for genes affiliated with Fibrous Dysplasia

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Sources for Fibrous Dysplasia

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4CDC
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23GTR
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26ICD10
27ICD10 via Orphanet
28ICD9CM
29IUPHAR
30KEGG
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40NDF-RT
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47OMIM via Orphanet
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57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet