MCID: FBR083
MIFTS: 23

Fibrous Dysplasia/mccune-Albright Syndrome

Aliases & Classifications for Fibrous Dysplasia/mccune-Albright Syndrome

MalaCards integrated aliases for Fibrous Dysplasia/mccune-Albright Syndrome:

Name: Fibrous Dysplasia/mccune-Albright Syndrome 23
Fd/mas 23

Summaries for Fibrous Dysplasia/mccune-Albright Syndrome

MalaCards based summary : Fibrous Dysplasia/mccune-Albright Syndrome, also known as fd/mas, is related to mccune-albright syndrome, somatic, mosaic and fibrous dysplasia. An important gene associated with Fibrous Dysplasia/mccune-Albright Syndrome is GH1 (Growth Hormone 1), and among its related pathways/superpathways are PI3K-Akt signaling pathway and Prolactin Signaling Pathway. The drugs Etidronic acid and Bone Density Conservation Agents have been mentioned in the context of this disorder. Affiliated tissues include bone, brain and bone marrow.

GeneReviews: NBK274564

Related Diseases for Fibrous Dysplasia/mccune-Albright Syndrome

Diseases related to Fibrous Dysplasia/mccune-Albright Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 33)
id Related Disease Score Top Affiliating Genes
1 mccune-albright syndrome, somatic, mosaic 11.7
2 fibrous dysplasia 10.7
3 acromegaly 10.3
4 g6pc3 deficiency 9.9 GH1 PRL
5 combined t cell and b cell immunodeficiency 9.9 GH1 PRL
6 aortic valve atresia 9.9 GH1 PRL
7 intermittent squint 9.9 GH1 PRL
8 lactic acidosis 9.9 GH1 PRL
9 glassy cell carcinoma of the cervix 9.9 GH1 PRL
10 protein s deficiency 9.9 GH1 PRL
11 hypothyroidism, congenital, nongoitrous 4 9.9 GH1 PRL
12 pityriasis rotunda 9.9 GH1 PRL
13 pituitary adenoma, prolactin-secreting 9.9 GH1 PRL
14 strabismus 9.8 GH1 PRL
15 osseous heteroplasia, progressive 9.8 GH1 PRL
16 47,xyy syndrome 9.8 GH1 PRL
17 diencephalic neoplasm 9.8 GH1 PRL
18 cold-induced sweating syndrome 2 9.8 GH1 PRL
19 acute myeloid leukemia, susceptibility, gata2-related 9.8 GH1 PRL
20 psychogenic movement 9.8 GH1 PRL
21 molybdenum cofactor deficiency b 9.8 GH1 PRL
22 worth's syndrome 9.8 GH1 PRL
23 adrenal cortex disease 9.7 GH1 PRL
24 uterine ligament clear cell adenocarcinoma 9.7 GH1 PRL
25 alpha-methylacyl-coa racemase deficiency 9.7 GH1 PRL
26 pituitary adenoma, acth-secreting 9.7 GH1 PRL
27 allergic asthma 9.7 GH1 PRL
28 usher syndrome, type 1f 9.6 GH1 PRL
29 skin meningioma 9.6 GH1 PRL
30 chromosome 11p13 deletion syndrome, distal 9.5 GH1 PRL
31 childhood optic nerve glioma 9.5 GH1 PRL
32 lung cancer susceptibility 2 9.4 GH1 PRL
33 thrombophilia 9.2 GH1 PRL

Graphical network of the top 20 diseases related to Fibrous Dysplasia/mccune-Albright Syndrome:



Diseases related to Fibrous Dysplasia/mccune-Albright Syndrome

Symptoms & Phenotypes for Fibrous Dysplasia/mccune-Albright Syndrome

Drugs & Therapeutics for Fibrous Dysplasia/mccune-Albright Syndrome

Drugs for Fibrous Dysplasia/mccune-Albright Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 24)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Etidronic acid Approved Phase 2, Phase 3 7414-83-7, 2809-21-4 3305
2 Bone Density Conservation Agents Phase 2, Phase 3
3 calcium channel blockers Phase 2, Phase 3
4 Calcium, Dietary Phase 2, Phase 3
5 Diphosphonates Phase 2, Phase 3
6 Risedronate Sodium Phase 2, Phase 3 115436-72-1
7 Hormone Antagonists Phase 3,Phase 2,Phase 1
8 Hormones Phase 3,Phase 2,Phase 1
9 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 2,Phase 1
10
Alendronate Approved Phase 2 121268-17-5, 66376-36-1 2088
11
Anastrozole Approved, Investigational Phase 2 120511-73-1 2187
12
Testolactone Approved Phase 2 968-93-4 13769
13
Fulvestrant Approved, Investigational Phase 2 129453-61-8 104741 17756771
14 Antineoplastic Agents, Hormonal Phase 2
15 Aromatase Inhibitors Phase 2,Phase 1
16 Estrogen Antagonists Phase 2,Phase 1
17 Estrogens Phase 2,Phase 1
18 Steroid Synthesis Inhibitors Phase 2,Phase 1
19 Estrogen Receptor Antagonists Phase 2
20 Phosphodiesterase 4 Inhibitors Phase 1, Phase 2
21
Letrozole Approved, Investigational Phase 1 112809-51-5 3902
22
Histamine Approved, Investigational 75614-87-8, 51-45-6 774
23
Histamine Phosphate 51-74-1 65513
24 Neurotransmitter Agents

Interventional clinical trials:

(show all 15)

id Name Status NCT ID Phase Drugs
1 Effect of Risedronate on Bone Morbidity in Fibrous Dysplasia of Bone Unknown status NCT00445575 Phase 2, Phase 3 risedronate;placebo;risedronate;placebo
2 A Study of the Effects of Pegvisomant on Growth Hormone Excess in McCune-Albright Syndrome Completed NCT00017927 Phase 3 Pegvisomant
3 TOCILIZUMAB IN FIBROUS DYSPLASIA OF BONE Unknown status NCT01791842 Phase 2 Tocilizumab;Placebo
4 Alendronate to Treat Polyostotic Fibrous Dysplasia and McCune-Albright Syndrome Completed NCT00001728 Phase 2 Fosamax (Alendronate)
5 Arimidex in McCune Albright Syndrome Completed NCT00055302 Phase 2 Arimidex 1 mg
6 Testolactone for the Treatment of Girls With LHRH Resistant Precocious Puberty Completed NCT00001181 Phase 2 Testolactone
7 Faslodex in McCune Albright Syndrome Active, not recruiting NCT00278915 Phase 2 Fulvestrant
8 PET Imaging of Phosphodiesterase-4 (PDE4) in Brain and Peripheral Organs of McCune-Albright Syndrome Not yet recruiting NCT02743377 Phase 1, Phase 2
9 Effects of Letrozole on Precocious Puberty Due to McCune Albright Syndrome Completed NCT00006174 Phase 1 Letrozole
10 Histamine Responsiveness in McCune-Albright Syndrome Unknown status NCT00318097
11 Studies on Abnormal Bone From Patients With Polyostotic Fibrous Dysplasia and McCune Albright Syndrome Completed NCT00001973
12 Bone Marrow Injection to Replace Diseased Bone in Polyostotic Fibrous Dysplasia and McCune-Albright Syndrome Completed NCT00001851
13 Fibrous Dysplasia, McCune-Albright Syndrome Patient Registry Recruiting NCT03231644
14 Screening and Natural History of Patients With Polyostotic Fibrous Dysplasia and McCune-Albright Syndrome Recruiting NCT00001727
15 Interest of Serum Periostin Dosage in Patients With Bone Fibrous Dysplasia Recruiting NCT02868645

Search NIH Clinical Center for Fibrous Dysplasia/mccune-Albright Syndrome

Genetic Tests for Fibrous Dysplasia/mccune-Albright Syndrome

Anatomical Context for Fibrous Dysplasia/mccune-Albright Syndrome

MalaCards organs/tissues related to Fibrous Dysplasia/mccune-Albright Syndrome:

39
Bone, Brain, Bone Marrow

Publications for Fibrous Dysplasia/mccune-Albright Syndrome

Articles related to Fibrous Dysplasia/mccune-Albright Syndrome:

id Title Authors Year
1
Fibrous Dysplasia/McCune-Albright Syndrome: Clinical and Translational Perspectives. ( 27492469 )
2016
2
Oral rehabilitation with endosseous implants in a patient with fibrous dysplasia (McCune-Albright syndrome): a case report. ( 19022142 )
2008
3
A novel technique based on a PNA hybridization probe and FRET principle for quantification of mutant genotype in fibrous dysplasia/McCune-Albright syndrome. ( 15096559 )
2004
4
Acromegaly with fibrous dysplasia: McCune-Albright Syndrome -- clinical studies in 3 cases and brief review of literature--. ( 14709853 )
2003
5
Fibrous Dysplasia/McCune-Albright Syndrome ( 25719192 )
1993
6
[A case of fibrous dysplasia (McCune Albright syndrome) associated with acromegaly]. ( 2070893 )
1991
7
Estrogen receptors in bone in a patient with polyostotic fibrous dysplasia (McCune-Albright syndrome). ( 3398893 )
1988
8
Growth hormone excess and sexual precocity in polyostotic fibrous dysplasia (McCune-Albright syndrome): evidence for abnormal hypothalamic function. ( 1185394 )
1975
9
Picture of the month. Polyostotic fibrous dysplasia (McCune-Albright syndrome). ( 4745152 )
1973

Variations for Fibrous Dysplasia/mccune-Albright Syndrome

Expression for Fibrous Dysplasia/mccune-Albright Syndrome

Search GEO for disease gene expression data for Fibrous Dysplasia/mccune-Albright Syndrome.

Pathways for Fibrous Dysplasia/mccune-Albright Syndrome

Pathways related to Fibrous Dysplasia/mccune-Albright Syndrome according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.79 GH1 PRL
2
Show member pathways
11.61 GH1 PRL
3
Show member pathways
11.19 GH1 PRL
4
Show member pathways
10.24 GH1 PRL

GO Terms for Fibrous Dysplasia/mccune-Albright Syndrome

Cellular components related to Fibrous Dysplasia/mccune-Albright Syndrome according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 endosome lumen GO:0031904 8.62 GH1 PRL

Biological processes related to Fibrous Dysplasia/mccune-Albright Syndrome according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 positive regulation of JAK-STAT cascade GO:0046427 8.96 GH1 PRL
2 JAK-STAT cascade involved in growth hormone signaling pathway GO:0060397 8.62 GH1 PRL

Molecular functions related to Fibrous Dysplasia/mccune-Albright Syndrome according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 8.96 GH1 PRL
2 prolactin receptor binding GO:0005148 8.62 GH1 PRL

Sources for Fibrous Dysplasia/mccune-Albright Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
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43 MESH via Orphanet
44 MGI
46 NCI
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48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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