Fibrous Histiocytoma malady

Wikipedia: Benign fibrous histiocytomas (also known as \"Dermal dendrocytoma,\" \"Dermatofibroma,\" \"Fibrous...⁴⁴ more...

MalaCards: Fibrous Histiocytoma, also known as benign fibrous histiocytoma (morphologic abnormality), is related to pleomorphic malignant fibrous histiocytoma and cutaneous fibrous histiocytoma. An important gene associated with Fibrous Histiocytoma is MFHAS1 (malignant fibrous histiocytoma amplified sequence 1), and among its related pathways are Breast Cancer Regulation by Stathmin1 and Glioma Invasiveness. The compounds s 100 and reticulin have been mentioned in the context of this disorder. Affiliated tissues include skin, liver and lung, and related mouse phenotypes are endocrine/exocrine gland and respiratory system.

Aliases & Descriptions:

fibrous histiocytoma 6 8 benign fibrous histiocytoma (morphologic abnormality) 6 fibrous histiocytoma nos (morphologic abnormality) 6 fibroxanthoma nos (morphologic abnormality) 6

cutaneous fibrous histiocytoma 43 histiocytoma, benign fibrous 43 histiocytoma fibrous 32

Diseases related to fibrous histiocytoma by text searches and GeneDecks gene sharing:

(show top 50)    (show all 940)

id	Related Disease	Score	Top Affiliating Genes
1	pleomorphic malignant fibrous histiocytoma	34.5	IL6R, EZR, HLA-A
2	cutaneous fibrous histiocytoma	33.9	VIM, NAA11, B3GAT1, CD34, CD68, MMP11
3	malignant fibrous histiocytoma	32.8	KITLG, PCNA, BTC, RB1, SERPINA1, SERPINA3
4	sclerosing hemangioma	32.2	RB1, MUC1, CDKN2A, MMP9, ENO2, TP53
5	leukemoid reaction	31.8	KITLG, IL3, CRP, CSF3
6	liposarcoma	31.8	RB1, VIM, VEGFA, LPL, BCL2, MVP
7	malignant fibroxanthoma	31.3	VIM, S100A9, CD34, FOXO4, TP53, TSPAN31
8	hypoglycemia	30.6	PCNA, VIM, VEGFA, LPL, IL6, ENO2
9	giant cell tumor	30.3	SERPINA3, VIM, MUC1, S100B, MMP9, MITF
10	gliosarcoma	29.8	KITLG, RB1, VIM, S100B, CDKN2A, CDK4
11	immunodeficiency	29.7	CISH, IL6, IL7, HLA-A, TNFRSF8, PTPRC
12	anaplastic large cell lymphoma	29.4	PCNA, RB1, SERPINA1, SERPINA3, BSG, BCL2
13	soft tissue sarcoma	28.9	KITLG, PCNA, RB1, SERPINA1, SERPINA3, VIM
14	dermatofibrosarcoma	28.6	VIM, MUC1, S100A1, S100B, CD163, CD34
15	dermatofibrosarcoma protuberans	28.6	VIM, MUC1, S100A1, S100B, CD163, CD34
16	fibromatosis	28.0	PCNA, RB1, VIM, BSG, S100A1, CD163
17	germ cell tumor	27.7	KITLG, PCNA, RB1, VEGFA, BMP2, BCL2
18	pheochromocytoma	27.6	BSG, VEGFA, BCL2, S100A1, S100B, MSH2
19	sinusitis	27.2	PCNA, SERPINA3, VIM, VEGFA, MYOG, MUC1
20	chordoma	27.2	SERPINA3, VIM, VEGFA, MUC1, MTAP, S100A1
21	histiocytoma	26.8	KITLG, PCNA, BTC, RB1, SERPINA1, SERPINA3
22	polyposis	25.6	KITLG, PCNA, RB1, VIM, VEGFA, BMP2
23	leiomyoma	24.8	PCNA, VIM, BSG, VEGFA, MYOG, BMP2
24	osteosarcoma	24.5	PCNA, RB1, VIM, VEGFA, LPL, MYOG
25	fibrosarcoma	24.4	KITLG, RB1, VIM, VEGFA, MYOD1, BCL2
26	retinoblastoma	23.2	KITLG, PCNA, RB1, VIM, BSG, VEGFA
27	neuronitis	19.5	KITLG, PCNA, RB1, SERPINA1, SERPINA3, VIM
28	sarcoma	19.4	KITLG, PCNA, RB1, SERPINA1, SERPINA3, VIM
29	colorectal cancer	19.1	KITLG, PCNA, RB1, SERPINA1, VIM, BSG
30	adenocarcinoma	18.6	KITLG, PCNA, BTC, RB1, SERPINA1, SERPINA3
31	hepatitis	17.7	KITLG, PCNA, RB1, SERPINA1, SERPINA3, VIM
32	carcinoma	15.3	KITLG, PCNA, BTC, RB1, SERPINA1, SERPINA3
33	ossifying fibromyxoid tumor	14.2	VIM, S100A1, S100B, ACTC1, DES
34	cutaneous leiomyosarcoma	14.2	VIM, MUC1, S100B, ACTC1, DES
35	spindle cell sarcoma	14.2	VIM, MUC1, S100B, ACTC1, DES
36	pseudosarcomatous fibromatosis	14.2	VIM, MYOG, ACTC1, DES
37	mesenchymal chondrosarcoma	14.1	VIM, MUC1, SPARC, DES
38	glomus tumor	14.1	VIM, MUC1, S100A1, S100B, CD34, ACTC1
39	myxoid liposarcoma of the ovary	14.1	ATF1, FUS, CDK4, MDM2, EWSR1, DDIT3
40	rectum sarcomatoid carcinoma	14.1	VIM, MUC1, ACTC1, DES
41	botryoid rhabdomyosarcoma	14.1	MYOG, MYOD1, ACTC1, DES
42	chondroid chordoma	14.1	VIM, MUC1, S100A1, S100B
43	congenital granular cell tumor	14.1	SERPINA1, VIM, S100B, CD68, ENO2
44	cystic nephroma	14.1	VIM, MUC1, ACTC1, DES
45	chondroma	14.1	SERPINA3, S100A1, CDK4, MDM2, HMGA2, PDGFRA
46	parachordoma	14.1	VIM, MUC1, S100B, DES
47	congenital epulis	14.1	VIM, S100B, ENO2, DES
48	malignant mesenchymoma	14.1	MYOG, MYOD1, DES
49	epithelioid leiomyosarcoma	14.1	VIM, ACTC1, DES
50	glomangiomyoma	14.1	VIM, ACTC1, DES

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to fibrous histiocytoma:

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MGI Mouse Phenotypes related to fibrous histiocytoma:

²⁵ (show all 29)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	endocrine/exocrine gland phenotype	MP:0005379	10.0	CSF1R, DLG1, HMGA2, EWSR1, MITF, FUS
2	respiratory system phenotype	MP:0005388	9.9	LPL, MYOG, MYOD1, APOE, MAPK8IP3, F13A1
3	embryogenesis phenotype	MP:0005380	9.7	ETS1, DLG1, CREB1, PDGFRA, SLC2A3, GATA3
4	other phenotype	MP:0005395	9.7	ABCB1, PDGFRA, NOS2, PTGS2, APOE, MMP14
5	craniofacial phenotype	MP:0005382	9.6	PDGFRB, TFE3, SLC4A4, GATA3, PDGFRA, DLG1
6	renal/urinary system phenotype	MP:0005367	9.3	PDGFB, PDGFRA, PDGFRB, HIF1A, SLC4A1, GATA3
7	adipose tissue phenotype	MP:0005375	9.3	IGF1, HSPB2, EWSR1, HMGA2, TP53, PTGS2
8	reproductive system phenotype	MP:0005389	9.3	PTGS2, DLG1, NOS2, PDGFB, PDGFRA, CSF1R
9	liver/biliary system phenotype	MP:0005370	9.1	HIF1A, ABCB1, PTPRC, PTN, TP53, IL6
10	nervous system phenotype	MP:0003631	8.9	KITLG, RB1, BMP2, KCNA1, MSH2, ATF1
11	limbs/digits/tail phenotype	MP:0005371	8.8	IGF2, F2R, HMGA2, DLG1, CTGF, PDGFRA
12	normal phenotype	MP:0002873	8.7	MMP14, MMP16, FOXO4, MITF, IL6R, MCM2
13	integument phenotype	MP:0010771	8.7	MITF, MDM2, MCM2, EWSR1, HMGA2, EREG
14	hematopoietic system phenotype	MP:0005397	8.6	ETS1, PTN, PTPRC, SPARC, CR2, PLEK
15	digestive/alimentary phenotype	MP:0005381	8.5	SLC4A4, APOE, MCM2, CCL2, IGF2, F2R
16	pigmentation phenotype	MP:0001186	8.4	CCL2, TP53, PDGFB, PDGFRA, TFE3, GATA3
17	tumorigenesis	MP:0002006	8.3	MET, IL3, IL6, MDM2, MCM2, MAP3K5
18	no phenotypic analysis	MP:0003012	8.2	F2R, TP53, PTGS2, DLG1, PDGFB, SYP
19	hearing/vestibular/ear phenotype	MP:0005377	8.1	GJB6, HMGA2, PTN, CTGF, ABCB1, CSF1R
20	behavior/neurological phenotype	MP:0005386	8.0	SPARC, DDIT3, DLG1, PTPRZ1, PTN, HMGA2
21	muscle phenotype	MP:0005369	7.4	IL6, MDM2, APOE, MCM2, CCL2, IGFBP5
22	immune system phenotype	MP:0005387	7.2	IL6, IL6R, MCM2, HSPB2, EWSR1, GJB6
23	skeleton phenotype	MP:0005390	7.1	RB1, VEGFA, MYOG, MYOD1, BMP2, CDKN2A
24	vision/eye phenotype	MP:0005391	7.0	IGF2, F2R, HSPB2, EREG, TP53, PTGS2
25	growth/size phenotype	MP:0005378	6.7	MET, IL6, MDM2, APOE, MCM2, F2R
26	cellular phenotype	MP:0005384	5.7	ENO2, NOS2, PDGFRA, PDGFRB, ABCB1, ACTC1
27	mortality/aging	MP:0010768	5.7	VEGFA, CCL2, F2R, F13A1, HSPB2, EZR
28	cardiovascular system phenotype	MP:0005385	5.1	LPL, MYOD1, BMP2, BCL2, KCNA1, MTAP
29	homeostasis/metabolism phenotype	MP:0005376	3.3	KITLG, MMP2, MMP3, MMP9, MITF, MET

Articles related to fibrous histiocytoma:

(show top 50)    (show all 118)

id	Title	Authors	Year	Affiliating Genes
1	Malignant fibrous histiocytoma--pleomorphic sarcoma, NOS gene expression, histology, and clinical course. A pilot study. (19159951)	Daigeler A.... Marcus L.	2010	PDGFRA, LPL, ENO2
2	The expression of hDlg as a biomarker of the outcome in malignant fibrous histiocytomas. (20127000)	Niimi R.... Uchida A.	2010	DLG1
3	Podoplanin expression in fibrous histiocytomas and cellular neurothekeomas. (19318798)	Kaddu S.... Leinweber B.	2009	PDPN
4	Inflammatory malignant fibrous histiocytoma of the spermatic cord infiltrating an inguinal leiomyoma. Case report with conceptual and bibliographic reviews (18592766)	Ruiz Liso J.M.... GarcA-a PAcrez M.A.	2008	VIM
5	Primary intracerebral angiomatoid fibrous histiocytoma: report of a case with a t(12;22)(q13;q12) causing type 1 fusion of the EWS and ATF-1 genes. (18300800)	Dunham C.... Perry A.	2008	ATF1
6	8-Nitroguanine as a potential biomarker for progression of malignant fibrous histiocytoma, a model of inflammation-related cancer. (17914567)	Hoki Y.... Kawanishi S.	2007	HIF1A
7	EWSR1-CREB1 and EWSR1-ATF1 fusion genes in angiomatoid fibrous histiocytoma. (18094413)	Rossi S.... Hogendoorn P.C.	2007	ATF1, EWSR1
8	Prognostic significance of ezrin expression in pleomorphic malignant fibrous histiocytoma. (17465259)	Kim M.S.... Jeon D.G.	2007	EZR
9	EWSR1-CREB1 is the predominant gene fusion in angiomatoid fibrous histiocytoma. (17724745)	Antonescu C.R.... Ladanyi M.	2007	CREB1, ATF1, TFE3
10	Alterations of the retinoblastoma and p16 pathway correlate with promoter methylation in malignant fibrous histiocytomas. (17094467)	Brinck U.... Korabiowska M.	2006	RB1, CDKN2A
11	Interleukin-8 producing malignant fibrous histiocytoma with prolonged fever. (17460768)	Osaka S.... Sugitani M.	2006	IL8
12	Expression of CD163 in dermatofibroma, cellular fibrous histiocytoma, and dermatofibrosarcoma protuberans: comparison with CD68, CD34, and Factor XIIIa. (16640542)	Sachdev R.... Sundram U.	2006	F13A1, CD163
13	Coexpression of hepatocyte growth factor and its receptor c-Met correlates with high MIB-1 proliferative index in malignant fibrous histiocytoma. (15239348)	Yamamoto T.... Kurosaka M.	2004	MET, HGF
14	Analysis of central regulatory pathways in p53-deficient primary cultures of malignant fibrous histiocytoma exposed to ifosfamide. (15736417)	Schlott T.... Brinck U.	2004	MDM2
15	Inflammatory malignant fibrous histiocytomas and dedifferentiated liposarcomas: histological review, genomic profile, and MDM2 and CDK4 status favour a single entity. (15221942)	Coindre J.M.... Aurias A.	2004	CDK4, MDM2
16	Hypoglycemia associated with big insulin-like growth factor II produced during development of malignant fibrous histiocytoma. (14709848)	Kageyama K.... Suda T.	2003	IGF2
17	Anaplastic lymphoma kinase negative sarcomatoid variant of anaplastic large-cell lymphoma presenting as a malignant fibrous histiocytoma. (12799899)	Ogose A.... Hotta T.	2003	ALK
18	Most malignant fibrous histiocytomas developed in the retroperitoneum are dedifferentiated liposarcomas: a review of 25 cases initially diagnosed as malignant fibrous histiocytoma. (12640106)	Coindre J.M.... Aurias A.	2003	CDK4, MDM2
19	Malignant fibrous histiocytoma masquerading as germ cell tumor by producing beta-human chorionic gonadotropin and neuron-specific enolase. (12946774)	Froehner M.... Ockert D.	2003	CGB
20	Atypical fibrous histiocytoma of the scrotum. (15018121)	Huan Y.... Unger P.D.	2003	F13A1
21	Frequent expression of smooth muscle markers in malignant fibrous histiocytoma of bone. (12401825)	Ueda T.... Yoshikawa H.	2002	MYOD1
22	Myxoid malignant fibrous histiocytoma of the uterus: a case with immunohistochemical, ultrastructural and tumor cell culture studies. (11491017)	Kiyozuka Y.... Tsubura A.	2001	SERPINA3
23	Characterization of four cell lines derived from a human malignant fibrous histiocytoma of the maxillary sinus. (11435180)	Mori A.... Ohse S.	2001	CSF3
24	Malignant Fibrous Histiocytoma, Aggressive Fibromatosis and Benign Fibrous Tumors Express mRNA for the Metalloproteinase Inducer EMMPRIN and the Metalloproteinases MMP-2 and MT1-MMP. (18521441)	Ahlen J.... Backdahl M.	2001	MMP2, MMP14, BSG
25	Expression of bone morphogenetic protein and its receptors in osteosarcoma and malignant fibrous histiocytoma. (10939432)	Mehdi R.... Takaoka K.	2000	GDF10
26	Origin of histiocyte-like cells and multinucleated giant cells in malignant fibrous histiocytoma: neoplastic or reactive? (10227720)	Hatano H.... Naito M.	1999	CSF1R
27	Inflammatory malignant fibrous histiocytoma of the ovary producing interleukin-6: A case report. (10600313)	Yamakawa Y.... Saito S.	1999	CRP
28	Fibrous histiocytoma and fibrous tissue tumors of the orbit. (10026737)	Dalley R.W.	1999	VIM
29	Angiomatoid 'malignant' fibrous histiocytoma: a clinicopathologic study of 158 cases and further exploration of the myoid phenotype. (10571514)	Fanburg-Smith J.C.... Miettinen M.	1999	CR1, CR2, MYOD1
30	IL-6 in a pleomorphic type of malignant fibrous histiocytoma presenting high fever. (9670836)	Hamada T.... Inoue A.	1998	IL6
31	Human malignant fibrous histiocytomas in vitro: growth characteristics and their association with expression of mRNA for platelet-derived growth factor, transforming growth factor-alpha and their receptors. (10070317)	Abdiu A.... Wasteson A.	1998	PDGFRB
32	Proliferative activity (MIB-1 index) is an independent prognostic parameter in patients with high-grade soft tissue sarcomas of subtypes other than malignant fibrous histiocytomas: a retrospective immunohistological study including 216 soft tissue sarcomas. (9675593)	Jensen V.... Jensen O.M.	1998	BCL2
33	An unusual soft tissue tumor with features of angiomatoid malignant fibrous histiocytoma composed of bimodal CD34 and factor XIIIa positive dendritic cell subsets. CD34 and factor XIIIa in angiomatoid MFH. (9112273)	Silverman J.S.... Lomvardias S.	1997	F13A1
34	Malignant fibrous histiocytoma of the pancreas. (8870008)	Haba R.... Yamamoto S.	1996	SERPINA3
35	Immunohistochemistry of dermatofibromas and benign fibrous histiocytomas. (7499573)	Prieto V.G.... Shea C.R.	1995	F13A1
36	Pulmonary malignant fibrous histiocytoma treated with cisplatin plus etoposide followed by surgery (8538096)	Morikawa T.... Hayashi Y.	1995	SERPINA3
37	P-53 positivity and high proliferative index: factors of bad prognosis in malignant fibrous histiocytomas. (8900926)	Brinck U.... Schauer A.	1995	MKI67
38	Prognostic implication of the p53 protein and Ki-67 antigen immunohistochemistry in malignant fibrous histiocytoma. (8625155)	Yang P.... Hizawa K.	1995	MKI67
39	Molecular and immunohistochemical p53 status in liposarcoma and malignant fibrous histiocytoma: identification of seven new mutations for soft tissue sarcomas. (8630896)	Taubert H.... Rath F.W.	1995	TP53
40	Immunophenotypic and immunoelectron microscopic characterization of major constituent cells in malignant fibrous histiocytoma using human cell lines and their transplanted tumors in immunodeficient mice. (7783426)	Takeya M.... Takahashi K.	1995	CCL2, IL3
41	Enhanced expression of catalytic subunit isoform PP1 gamma 1 of protein phosphatase type 1 in malignant fibrous histiocytoma. (7850251)	Yamada T.... Matsumoto K.	1994	DUSP19
42	Malignant fibrous histiocytoma in chordoma--immunohistochemical evidence of transformation from chordoma to malignant fibrous histiocytoma. (8091802)	Choi Y.J.... Kim T.S.	1994	VIM, MUC1, SERPINA3
43	Biological characteristics of a continuous cultured cell line derived from a human malignant fibrous histiocytoma. (7599108)	Sekiguchi M.... Kamada N.	1994	TFRC
44	Malignant fibrous histiocytoma phenotype in pleomorphic sarcoma differentiation in recurrent disease. (8311656)	Costa M.J.	1994	DES
45	Benign fibrous histiocytoma of the stomach: report of a case. (8118125)	Zhang W.... Kunitomi K.	1993	SERPINA3
46	A case of inflammatory malignant fibrous histiocytoma of the colon. (7690726)	Murata I.... Tomita M.	1993	CRP
47	Expression of the human progenitor cell antigen CD34 (HPCA-1) distinguishes dermatofibrosarcoma protuberans from fibrous histiocytoma in formalin-fixed, paraffin-embedded tissue. (7681857)	Kutzner H.	1993	CD34
48	Comparative immunohistochemistry of malignant fibrous histiocytoma and sarcomatoid carcinoma of the urinary tract. (1851349)	Hasui Y.... Sumiyoshi A.	1991	MUC1, F13A1, SERPINA3
49	Fibrous histiocytoma of the tongue base. (2163249)	Takimoto T.... Umeda R.	1990	SERPINA3
50	Immunohistochemical study of 4-hydroxyaminoquinoline 1-oxide-induced rat malignant fibrous histiocytoma. (2158461)	Yamamoto H.... Fujishiro K.	1990	SERPINA3

Genes related to fibrous histiocytoma according to GeneCards:

(show top 50)    (show all 127)

id	Symbol	Description	Score	GeneCards Section Context
1	MFHAS1	malignant fibrous histiocytoma amplified sequence 1	11.1	Summaries, Transcripts, Proteins, Expressions (show all 7 sections) Aliases & Descriptions, Orthologs, Publications
2	ATF1	activating transcription factor 1	11.1	Summaries, Publications
3	CD68	CD68 molecule	11.0	Publications
4	MYOD1	myogenic differentiation 1	11.0	Publications
5	F13A1	coagulation factor XIII, A1 polypeptide	11.0	Publications
6	DES	desmin	11.0	Publications
7	IL6R	interleukin 6 receptor	11.0	Publications
8	VIM	vimentin	11.0	Publications
9	MDM2	Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse)	11.0	Publications
10	EREG	epiregulin	11.0	Publications
11	SERPINA3	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3	11.0	Publications
12	MYOG	myogenin (myogenic factor 4)	11.0	Publications
13	HSPB2	heat shock 27kDa protein 2	11.0	Publications
14	EZR	ezrin	11.0	Publications
15	DDIT3	DNA-damage-inducible transcript 3	11.0	Publications
16	S100A1	S100 calcium binding protein A1	11.0	Publications
17	CD34	CD34 molecule	11.0	Publications
18	DUSP19	dual specificity phosphatase 19	11.0	Publications
19	CTGF	connective tissue growth factor	11.0
20	CCNA2	cyclin A2	11.0	Publications
21	HMGA2	high mobility group AT-hook 2	11.0
22	SPARC	secreted protein, acidic, cysteine-rich (osteonectin)	11.0
23	TNFRSF8	tumor necrosis factor receptor superfamily, member 8	11.0
24	ACTC1	actin, alpha, cardiac muscle 1	11.0	Publications
25	SERPINA1	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1	11.0
26	MKI67	antigen identified by monoclonal antibody Ki-67	11.0	Publications
27	MUC1	mucin 1, cell surface associated	11.0	Publications
28	BMP2	bone morphogenetic protein 2	11.0	Publications
29	S100B	S100 calcium binding protein B	11.0	Publications
30	PDGFRB	platelet-derived growth factor receptor, beta polypeptide	11.0	Publications
31	CDK4	cyclin-dependent kinase 4	11.0	Publications
32	PTPRC	protein tyrosine phosphatase, receptor type, C	11.0	Publications
33	MSH2	mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)	11.0	Publications
34	NOS2	nitric oxide synthase 2, inducible	11.0	Publications
35	HLA-A	major histocompatibility complex, class I, A	11.0	Publications
36	ALK	anaplastic lymphoma receptor tyrosine kinase	11.0	Publications
37	TSPAN31	tetraspanin 31	11.0	Publications
38	NAA11	N(alpha)-acetyltransferase 11, NatA catalytic subunit	11.0
39	SMPDL3A	sphingomyelin phosphodiesterase, acid-like 3A	11.0	Publications
40	GDF10	growth differentiation factor 10	11.0	Publications
41	C19orf48	chromosome 19 open reading frame 48	11.0	Publications
42	KRT75	keratin 75	11.0	Publications
43	TRO	trophinin	11.0	Publications
44	PRUNE	prune homolog (Drosophila)	11.0	Expressions
45	KCNA1	potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)	11.0	Publications
46	FOXO4	forkhead box O4	11.0
47	BTC	betacellulin	11.0	Publications
48	SLC2A3	solute carrier family 2 (facilitated glucose transporter), member 3	11.0	Publications
49	SLC39A14	solute carrier family 39 (zinc transporter), member 14	11.0	Publications
50	CISH	cytokine inducible SH2-containing protein	11.0	Publications

Pathways related to fibrous histiocytoma according to GeneDecks:

(show top 50)    (show all 111)

id	Pathway	Score	Top Affiliating Genes
1	Breast Cancer Regulation by Stathmin136	10.2	GDF10, BTC, BMP2, ALK, PTN, PDGFB
2	Glioma Invasiveness36	10.0	GDF10, HGF, PDGFB, PTN, F2R, IL3
3	Ras Pathway36	9.9	BMP2, CTGF, MET, IL3, IGF2, ALK
4	14-3-3 Induced Intracellular Signaling36	9.9	PDGFRA, PDGFRB, CSF1R, GDF10, PDGFB, CTGF
5	Paxillin Interactions36	9.7	GDF10, PDGFRB, CSF1R, KITLG, PTN, CTGF
6	eNOS Signaling36	9.7	PDGFRB, HGF, GDF10, BMP2, IGF2, AREG
7	Akt Signaling36	9.5	PDGFRB, PDGFRA, PDGFB, CTGF, PTN, TNFRSF8
8	Telomerase Components in Cell Signaling36	9.5	RB1, BMP2, AREG, MET, IL3, IGF1
9	ERK5 Signaling36	9.5	IGF2, PTN, CTGF, CREB1, PDGFRB, GDF10
10	Nanog in Mammalian ESC Pluripotency36	9.4	KITLG, BTC, BMP2, AREG, GDF10, MET
11	ILK Signaling36	9.4	PDGFRA, PDGFB, CREB1, GDF10, CSF1R, HIF1A
12	PTEN Pathway36	9.4	KITLG, GDF10, TP53, PDGFRA, PDGFB, CTGF
13	Apoptotic Pathways in Synovial Fibroblasts36	9.3	KITLG, BTC, BMP2, AREG, MET, IL3
14	Nuclear Receptor Activation by Vitamin-A36	9.3	GDF10, CREB1, PDGFB, PDGFRA, PDGFRB, IGF1
15	DHA Signaling36	9.3	IGF2, KITLG, GDF10, HGF, PDGFRB, PDGFRA
16	JNK Pathway36	9.3	BMP2, BTC, KITLG, GDF10, CSF1R, PDGFRB
17	PPAR Pathway36	9.2	PDGFRB, IGF2, IL6, KITLG, IL3, MET
18	GPCR Pathway36	9.2	KITLG, GDF10, BTC, BMP2, AREG, ALK
19	Activation of PKA through GPCR36	9.2	ALK, PTN, PTPRC, CTGF, CREB1, CRP
20	p70S6K Signaling36	9.2	IGF2, BTC, BMP2, KITLG, AREG, MET
21	mTOR Pathway36	9.2	HIF1A, PDGFB, CTGF, PTN, ALK, IGF1
22	p53 Mediated Apoptosis36	9.2	KITLG, BTC, BCL2, BMP2, GDF10, HGF
23	NFAT in Immune Response36	9.2	IL6, HGF, PDGFRB, PDGFRA, PDGFB, CTGF
24	Estrogen Pathway36	9.2	AREG, GDF10, HGF, CSF1R, MET, IL3
25	Activation of PKC through GPCR36	9.1	HGF, PDGFB, CREB1, CTGF, PTN, IGF2
26	Renin-Angiotensin Pathway36	9.1	CCL2, IL3, MET, AREG, BMP2, BTC
27	eIF2 Pathway36	9.1	IGF1, HGF, PDGFRB, IL6, PDGFRA, PDGFB
28	Activation of cAMP-Dependent PKA36	9.0	KITLG, MET, PDGFRA, PDGFRB, CSF1R, HGF
29	Mitochondrial Apoptosis36	9.0	IL6, MDM2, IGF2, IGF1, TP53, PTN
30	Cellular Apoptosis Pathway36	9.0	IGF1, TP53, PTN, CTGF, PDGFB, PDGFRA
31	Melanoma20	9.0	MET, MITF, CDK4, CDKN2A, RB1, MDM2
32	GSK3 Signaling36	8.9	AREG, PDGFRB, BTC, KITLG, MET, IL3
33	Bladder cancer20	8.9	MMP9, IL8, TP53, MDM2, MMP2, MMP1
34	ERK Signaling36	8.8	ETS1, ALK, IGF2, IL7, KITLG, BTC
35	TGF-Beta Pathway36	8.7	PTN, IGF2, CCL2, MET, IL3, IL6
36	Rho Family GTPases36	8.7	GFAP, DES, CSF1R, CSF3, HGF, GDF10
37	MAPK Signaling36	8.7	GDF10, HGF, CSF1R, PDGFRB, PDGFRA, PDGFB
38	Tec Kinases Signaling36	8.6	CTGF, PDGFB, PDGFRA, PDGFRB, CSF1R, HGF
39	JAK-STAT Pathway36	8.6	KITLG, BTC, BMP2, BCL2, AREG, MET
40	MAPK Family Pathway36	8.6	BCL2, MET, IL3, IL6, IL6R, IL7
41	PAK Pathway36	8.5	IL7, IL8, CCL2, IGF2, IGF1, PTN
42	Molecular Mechanisms of Cancer36	8.5	HIF1A, CSF1R, HGF, GDF10, PDGFRA, PDGFB
43	Cytokine-cytokine receptor interaction20	8.5	IL6, VEGFA, BMP2, IL3, KITLG, IL6R
44	Cell adhesion ECM remodeling10	8.5	SPARC, EZR, IGF1, IGF2, HBEGF, MMP16
45	Cell adhesion_ECM remodeling41	8.4	MMP1, MMP14, MMP16, MMP2, MMP3, HBEGF
46	Antioxidant Action of Vitamin-C36	8.4	PDGFRA, PDGFB, CTGF, PTN, TNFRSF8, IGF1
47	p38 Signaling36	8.2	KITLG, BTC, BMP2, BCL2, AREG, MET
48	Pathways in cancer20	7.6	PDGFRA, NOS2, TP53, ETS1, MDM2, MET
49	Pancreatic Adenocarcinoma36	6.6	BTC, RB1, BMP2, BCL2, CDKN2A, CDK4
50	NF-KappaB (p50-p65) Pathway36	INF	, AREG, BMP2, BTC, GDF10, KITLG

Compounds related to fibrous histiocytoma according to GeneDecks:

(show top 50)    (show all 367)

id	Compound	Score	Top Affiliating Genes
1	s 10032	10.3	VIM, MUC1, S100B, ENO2, F13A1, ACTC1
2	reticulin32	10.3	PCNA, VIM, MUC1, S100B, CD34, F13A1
3	glycogen32 18	11.3	VIM, MUC1, S100A1, S100B, CEACAM5, CDK4
4	ascorbic acid32 18	11.2	PCNA, MYOG, BMP2, S100B, CDK4, MMP2
5	calcitriol32 42 9 18 9	13.9	KITLG, RB1, BMP2, S100A9, CDK4, MMP14
6	biotin32 9 18 9	12.8	KITLG, PCNA, RB1, VIM, LPL, MUC1
7	sp 60012532 42	10.7	MMP1, TP53, CTGF
8	ag 147832	9.6	BTC, MMP14, MMP2, MMP9, AREG, MET
9	forskolin32 42 9 9	12.6	VIM, MYOG, BMP2, MUC1, S100B, ATF1
10	glucose32	9.4	BTC, MYOG, MYOD1, CISH, S100B, CGB
11	etoposide32 42 9 9	12.4	PCNA, RB1, BCL2, MVP, S100B, CGB
12	estradiol32 9 18 9	12.4	KITLG, PCNA, RB1, SERPINA3, VIM, MUC1
13	silver32	9.3	PCNA, SERPINA3, S100A1, CEACAM5, CDKN2A, CD34
14	irinotecan32 34 9 9	12.2	VEGFA, CEACAM5, CDKN2A, MKI67, MDM2, CCNA2
15	cyclic amp32 18	10.2	RB1, MYOD1, CGB, ATF1, CDKN2A, CDK4
16	arginine32	9.1	SERPINA3, MYOD1, BMP2, B3GAT1, S100B, CDK4
17	cytarabine32 34 9 9	12.0	KITLG, PCNA, RB1, VIM, BCL2, MVP
18	butyrate32	8.8	KITLG, RB1, VIM, MYOG, MYOD1, BCL2
19	histamine32 18	9.8	KITLG, PCNA, VIM, B3GAT1, IL3, IL6R
20	5fluorouracil32	8.7	KITLG, PCNA, RB1, VEGFA, BCL2, MVP
21	agar32	8.7	KITLG, RB1, VIM, MUC1, MTAP, CEACAM5
22	wortmannin32 42	9.7	KITLG, BTC, VIM, BMP2, BCL2, S100B
23	doxorubicin32 34 9 9	11.5	KITLG, VIM, MVP, CEACAM5, MSH2, MSH6
24	adriamycin32	8.5	RB1, VIM, BCL2, MVP, MUC1, CEACAM5
25	pge232	8.5	BMP2, ATF1, MMP1, MMP3, IGFBP5, F2R
26	glutamate32	8.2	PCNA, VIM, BSG, MSH2, MMP2, MMP3
27	nitric oxide32 9 18 9	11.1	KITLG, RB1, SERPINA1, MYOG, BMP2, CISH
28	cisplatin32 34 9 9	11.0	KITLG, PCNA, RB1, VEGFA, BCL2, MVP
29	procollagen32	8.0	PCNA, VIM, BMP2, MMP1, MMP14, MMP2
30	paclitaxel32 34 9 9	11.0	KITLG, PCNA, RB1, VIM, VEGFA, BCL2
31	tgf beta132	8.0	KITLG, MYOD1, CDK4, MMP1, MMP14, MMP2
32	cysteine32	7.9	PCNA, SERPINA1, SERPINA3, MYOG, MUC1, S100A1
33	ribonucleic acid32	7.8	KITLG, MYOG, BMP2, MUC1, CEACAM5, MMP1
34	estrogen32	7.7	PCNA, SERPINA1, SERPINA3, BSG, LPL, MYOG
35	cholesterol32 9 18 9	10.6	KITLG, RB1, SERPINA1, SERPINA3, BSG, LPL
36	atp32	7.5	RB1, MYOD1, MVP, MTAP, S100A9, MSH2
37	matrigel32	7.5	BTC, RB1, VIM, BSG, VEGFA, BMP2
38	lactate32	7.3	KITLG, PCNA, VIM, BSG, LPL, BMP2
39	actinomycin d32	7.3	KITLG, RB1, VIM, VEGFA, MYOD1, BMP2
40	sb 20358032 42	8.2	RB1, VIM, BSG, VEGFA, BMP2, BCL2
41	alanine32	7.1	KITLG, PCNA, MYOD1, BMP2, B3GAT1, S100B
42	oxygen32 18	7.9	KITLG, RB1, SERPINA1, SERPINA3, MYOG, MYOD1
43	calcium32 9 18 9	9.8	KITLG, BTC, RB1, SERPINA3, MYOG, MYOD1
44	testosterone32 9 18 9	9.8	KITLG, PCNA, RB1, VIM, LPL, MYOG
45	cyclosporin a32 42	7.7	KITLG, BSG, LPL, BMP2, MVP, S100B
46	lipid32	6.6	KITLG, RB1, SERPINA1, SERPINA3, VIM, BSG
47	genistein32 9 18 9	9.0	KITLG, PCNA, RB1, VIM, VEGFA, LPL
48	retinoic acid32 42 18	7.7	KITLG, RB1, MYOG, MYOD1, BMP2, S100A9
49	dexamethasone32 42 34 9 9	8.9	KITLG, PCNA, RB1, SERPINA3, VIM, VEGFA
50	paraffin32	4.7	KITLG, PCNA, RB1, SERPINA1, SERPINA3, VIM

Cellular components related to fibrous histiocytoma according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	platelet alpha granule lumen	GO:031093	9.8	HGF, PDGFB, SPARC, F13A1, IGF1, VEGFA
2	basolateral plasma membrane	GO:016323	9.7	SLC4A4, SLC4A1, ABCC1, PDGFB, DLG1, EZR
3	protein complex	GO:043234	9.3	PTGS2, TP53, MDM2, MITF, MMP9, CDKN2A
4	integral to plasma membrane	GO:005887	8.8	CR1, PDGFRA, PDGFRB, PDPN, ABCC1, HBEGF
5	proteinaceous extracellular matrix	GO:005578	8.2	CTGF, SPARC, PTPRZ1, MMP9, MMP3, MMP2
6	cytoplasm	GO:005737	7.2	DDIT3, DLG1, PTGS2, TNFRSF8, TP53, TRO
7	extracellular space	GO:005615	6.8	GDF10, IL3, MET, MMP9, MMP3, MMP2
8	extracellular region	GO:005576	5.5	HGF, LYZ, TFRC, HBEGF, KITLG, MMP9
9	nucleoplasm	GO:005654	INF	MDM2, MCM2, CCNA2, TP53, DDIT3, CREB1
10	plasma membrane	GO:005886	INF	CR2, CR1, CTGF, CYTH1, DLG1, PTPRC

Biological processes related to fibrous histiocytoma according to GeneDecks:

(show top 50)    (show all 55)

id	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway	GO:038091	10.5	PDGFRB, PDGFRA, VEGFA
2	phosphatidylinositol-mediated signaling	GO:048015	10.4	CSF1R, PDGFRB, PDGFRA, CREB1, IGF1, MDM2
3	myoblast proliferation	GO:051450	10.4	HGF, IGF1, MET
4	embryonic hemopoiesis	GO:035162	10.4	KITLG, IL3, HIF1A, GATA3
5	acute-phase response	GO:006953	10.3	CRP, IL6R, IL6, CD163, SERPINA3, SERPINA1
6	response to cytokine stimulus	GO:034097	10.3	SPARC, PTGS2, IL6R, BCL2, SERPINA1
7	response to gamma radiation	GO:010332	10.3	GATA3, PTPRC, TP53, CCL2, BCL2
8	ossification	GO:001503	10.3	CTGF, SPARC, IGF2, MMP9, BCL2, MYOG
9	positive regulation of ERK1 and ERK2 cascade	GO:070374	10.3	CSF1R, PDGFRB, PDGFRA, PDGFB, CTGF, F2R
10	positive regulation of apoptotic process	GO:043065	10.3	DDIT3, PTPRC, PTGS2, TNFRSF8, TP53, HMGA2
11	response to organic cyclic compound	GO:014070	10.2	SERPINA1, MSH2, ATF1, MET, ENO2, PTGS2
12	cell chemotaxis	GO:060326	10.2	HGF, ABCC1, PDGFRB, PDGFRA, PDGFB
13	retina vasculature development in camera-type eye	GO:061298	10.2	HIF1A, PDGFRB, PDGFRA
14	positive regulation of mitosis	GO:045840	10.2	PDGFRB, PDGFB, EREG, IGF1, IGF2, MET
15	vascular endothelial growth factor receptor signaling pathway	GO:048010	10.2	VEGFA, CCL2, PDGFRA, PDGFRB
16	monocyte chemotaxis	GO:002548	10.1	PDGFB, CCL2, IL6R, IL6
17	positive regulation of fibroblast proliferation	GO:048146	10.1	PDGFRA, PDGFB, EREG, IGF1, CDK4
18	positive regulation of cell division	GO:051781	10.1	PDGFB, PTN, EREG, IGF2, VEGFA, BTC
19	positive regulation of osteoblast differentiation	GO:045669	10.1	GDF10, IGF1, IL6R, IL6, BMP2
20	positive regulation of phosphatidylinositol 3-kinase cascade	GO:014068	10.1	HGF, PDGFRB, PDGFRA, PDGFB, F2R, IGF1
21	positive regulation of smooth muscle cell migration	GO:014911	10.1	PDGFRB, PDGFB, IGF1, BCL2
22	positive regulation of DNA replication	GO:045740	10.1	PDGFRA, PDGFB, EREG, IGF1, IL3, MET
23	cell cycle arrest	GO:007050	10.1	DDIT3, TP53, IL8, FOXO4, CDKN2A, MSH2
24	positive regulation of MAPK cascade	GO:043410	10.0	PDGFB, PTPRC, DUSP19, F2R, IGF1, IGF2
25	platelet degranulation	GO:002576	10.0	HGF, PDGFB, PLEK, SPARC, F13A1, IGF1
26	response to ethanol	GO:045471	9.9	S100A9, MMP9, CCL2, SPARC, ACTC1, GATA3
27	positive regulation of smooth muscle cell proliferation	GO:048661	9.9	HIF1A, HBEGF, PDGFRB, PDGFB, PTGS2, EREG
28	angiogenesis	GO:001525	9.9	TYMP, HIF1A, CTGF, EREG, CCL2, IL8
29	humoral immune response	GO:006959	9.8	GATA3, TFE3, CCL2, IL7, IL6, BCL2
30	platelet activation	GO:030168	9.7	HGF, PDGFB, PLEK, SPARC, F13A1, F2R
31	positive regulation of endothelial cell proliferation	GO:001938	9.7	HIF1A, PDGFB, CCL2, BMP2, VEGFA
32	response to estradiol stimulus	GO:032355	9.7	PDGFB, SERPINA1, MMP9, ENO2, ETS1, PTGS2
33	response to wounding	GO:009611	9.6	PDGFB, CTGF, F2R, MET, GFAP
34	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	9.4	HGF, PDGFB, TP53, IGF1, IGF2, IL6R
35	virus-host interaction	GO:019048	9.4	HAVCR1, TFRC, PDGFRA, CREB1, DLG1, TP53
36	negative regulation of cell proliferation	GO:008285	9.3	GATA3, PTGS2, TNFRSF8, TP53, BMP2, CDKN2A
37	response to drug	GO:042493	9.3	DDIT3, CREB1, PDGFB, ABCB1, ABCC1, ACTC1
38	positive regulation of cell migration	GO:030335	9.2	CSF1R, HBEGF, ABCC1, PDPN, PDGFRB, PDGFRA
39	response to hypoxia	GO:001666	9.2	HIF1A, PDGFB, NOS2, CRP, ETS1, CCL2
40	signal transduction	GO:007165	9.1	TNFRSF8, SPARC, CREB1, PDGFRB, PDPN, HBEGF
41	inflammatory response	GO:006954	8.9	LYZ, CSF1R, PDPN, CRP, PTGS2, CAMK1D
42	blood coagulation	GO:007596	8.8	SPARC, PLEK, NOS2, PDGFB, HGF, GATA3
43	collagen catabolic process	GO:030574	8.8	MMP9, MMP3, MMP2, MMP16, MMP11, MMP1
44	extracellular matrix disassembly	GO:022617	8.7	MMP9, MMP3, MMP2, MMP16, MMP14, MMP11
45	positive regulation of cell proliferation	GO:008284	8.6	BTC, PTN, DLG1, CTGF, PDGFB, PDGFRA
46	extracellular matrix organization	GO:030198	8.5	GFAP, MMP9, MMP3, MMP2, MMP16, MMP14
47	positive regulation of transcription, DNA-dependent	GO:045893	8.5	HMGA2, TP53, CREB1, PDGFB, HIF1A, GATA3
48	positive regulation of transcription from RNA polymerase II promoter	GO:045944	INF	ETS1, HMGA2, TP53, DDIT3, CREB1, HIF1A
49	G1 phase of mitotic cell cycle	GO:000080	INF	FOXO4, CDK4, CDKN2A, , RB1
50	cellular response to hypoxia	GO:071456	INF	HIF1A, PTGS2, TP53, MDM2, , VEGFA

Molecular functions related to fibrous histiocytoma according to GeneDecks:

(show all 13)

id	Name	GO ID	Score	Top Affiliating Genes
1	MutLalpha complex binding	GO:032405	10.0	PCNA, MSH2, MSH6
2	platelet-derived growth factor receptor binding	GO:005161	10.0	TYMP, PDGFRB, PDGFRA, PDGFB, VEGFA
3	fibronectin binding	GO:001968	10.0	CTGF, IGFBP5, MMP9, VEGFA
4	heparin binding	GO:008201	9.9	HBEGF, CTGF, PTPRC, PTN, CCL2, APOE
5	protein kinase binding	GO:019901	9.7	HIF1A, DLG1, PTPRC, TP53, CCNA2, MAP3K5
6	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive	GO:001077	9.6	HIF1A, TP53, HMGA2, MITF, GATA3
7	transcription factor binding	GO:008134	9.5	HMGA2, TP53, DDIT3, HIF1A, GATA3, ETS1
8	cytokine activity	GO:005125	9.4	GDF10, CSF3, IL7, IL6, IL3, BMP2
9	protein heterodimerization activity	GO:046982	9.3	ENO2, TP53, PDGFB, HIF1A, HGF, APOE
10	protein homodimerization activity	GO:042803	9.1	PTGS2, CR2, CRP, PLEK, NOS2, PDGFB
11	growth factor activity	GO:008083	8.8	IGF1, EREG, PTN, CTGF, PDGFB, HBEGF
12	metalloendopeptidase activity	GO:004222	8.4	MMP9, MMP3, MMP2, MMP16, MMP14, MMP11
13	protein binding	GO:005515	INF	EWSR1, CREB1, CRP, PLEK, NOS2, PDGFB