MCID: FBR003
MIFTS: 54

Fibrous Histiocytoma malady

Cancer diseases category

Summaries for Fibrous Histiocytoma

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66Wikipedia, 34MalaCards
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Wikipedia:66 Benign fibrous histiocytomas (also known as Dermal dendrocytoma,Dermatofibroma,Fibrous... more...

MalaCards: Fibrous Histiocytoma, also known as cutaneous fibrous histiocytoma, is related to cutaneous fibrous histiocytoma and sarcoma. An important gene associated with Fibrous Histiocytoma is ATF1 (activating transcription factor 1), and among its related pathways are Aurora B signaling and ERK Signaling. The compounds orcein and eosin have been mentioned in the context of this disorder. Affiliated tissues include bone, skin and breast, and related mouse phenotypes are tumorigenesis and normal.

Aliases & Classifications for Fibrous Histiocytoma

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63UMLS, 9Disease Ontology, 11DISEASES, 46Novoseek, 36MeSH, 59SNOMED-CT, 41NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

fibrous histiocytoma 9 11
cutaneous fibrous histiocytoma 63
histiocytoma, benign fibrous 63
benign fibrous histiocytoma 9
fibrous histiocytoma nos 9
histiocytoma fibrous 46
fibroxanthoma nos 9


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Disease Ontology9 DOID:4415
MeSH36 D018219
NCIt41 C3739

Related Diseases for Fibrous Histiocytoma

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18GeneCards, 19GeneDecks
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Diseases related to Fibrous Histiocytoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 206)
idRelated DiseaseScoreTop Affiliating Genes
1cutaneous fibrous histiocytoma31.3F13A1, DES
2sarcoma31.1DES, ATF1, F13A1, VIM, MYOD1, MUC1
3liposarcoma31.0DES, VIM, MDM2
4osteosarcoma30.9MYOD1, IL6R, MDM2
5dermatofibrosarcoma30.9MDM2
6dedifferentiated liposarcoma30.9DES, MDM2
7fibrosarcoma30.8MDM2, VIM, DES
8dermatofibrosarcoma protuberans30.7DES, F13A1, VIM, MUC1
9histiocytosis30.6F13A1, CD68
10epithelioid sarcoma30.6VIM, MUC1
11meningioma30.6VIM, MUC1, CD68
12leiomyosarcoma30.6DES, VIM, MYOD1, MUC1, MDM2
13hemangioma30.5CD68, F13A1
14malignant histiocytosis30.5SERPINA3
15malignant fibroxanthoma30.4CD68, DES, F13A1, SERPINA3, VIM, MYOD1
16spindle cell sarcoma30.4DES, VIM, MUC1
17chordoma30.4MUC1, VIM, DES
18hepatocellular carcinoma30.4MDM2, IL6R, F13A1, ATF1
19myxoid liposarcoma30.3ATF1
20angiosarcoma30.3SERPINA3, VIM, MUC1
21rhabdoid tumor30.3DES, VIM, MYOD1, MUC1
22cystadenocarcinoma30.3MUC1
23hemangiopericytoma30.3MDM2, MUC1, VIM, F13A1, DES
24fibromatosis30.2DES, VIM
25hodgkin's lymphoma30.2IL6R, MDM2, CD68
26adenocarcinoma30.2F13A1, SERPINA3, VIM, MUC1, MDM2
27non-hodgkin lymphoma30.2MYOD1, IL6R, MDM2
28rhabdomyosarcoma30.1DES, VIM, MYOD1, MDM2
29melanoma30.1DES, ATF1, F13A1, SERPINA3, VIM, MYOD1
30giant cell tumor30.0DES, F13A1, SERPINA3, VIM, MUC1
31histiocytoma11.5
32malignant fibrous histiocytoma of bone11.1
33diaphyseal medullary stenosis with malignant fibrous histiocytoma10.7
34pleomorphic malignant fibrous histiocytoma10.7
35aneurysm10.7
36hepatitis10.6
37burn scar10.5
38burns10.5
39leukemoid reaction10.5
40thyroiditis10.5
41soft tissue sarcoma10.5
42malignant skin fibrous histiocytoma10.4
43sclerosing hemangioma10.4
44benign deep fibrous histiocytoma10.3
45cerebritis10.3
46laryngitis10.3
47leukemia10.3
48mediastinitis10.3
49retinoblastoma10.3
50pleomorphic undifferentiated sarcoma10.3

Graphical network of the top 20 diseases related to Fibrous Histiocytoma:



Diseases related to fibrous histiocytoma

Symptoms for Fibrous Histiocytoma

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Drugs & Therapeutics for Fibrous Histiocytoma

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search CenterWatch for Fibrous Histiocytoma

Genetic Tests for Fibrous Histiocytoma

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Anatomical Context for Fibrous Histiocytoma

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34MalaCards
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MalaCards organs/tissues related to Fibrous Histiocytoma:

34
Bone, Skin, Breast, Lung, Heart, Liver, Spleen, Pancreas, Colon, Kidney, Ovary, Thyroid, Cervix, T cells, Tongue, Trachea, Adrenal gland, Lymph node, Smooth muscle, Prostate, Thymus, Brain, Endothelial, Monocytes, Testes, Testis, Uterus, Skeletal muscle, Bone marrow

Animal Models for Fibrous Histiocytoma or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Fibrous Histiocytoma:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.8MDM2, IL6R, MUC1, MYOD1
2MP:00028738.3ATF1, MYOD1, MUC1, IL6R, MDM2
3MP:00107688.1DES, ATF1, F13A1, VIM, MYOD1, IL6R
4MP:00053977.9CD68, MDM2, IL6R, VIM, F13A1, HAVCR1
5MP:00053877.7HAVCR1, ATF1, VIM, IL6R, MDM2, CD68

Publications for Fibrous Histiocytoma

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53PubMed
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Articles related to Fibrous Histiocytoma:

(show top 50)    (show all 715)
idTitleAuthorsYear
1
Refractory Malignant Fibrous Histiocytoma: CT-guided Treatment with a Multidisciplinary, Minimally Invasive Approach. (24325132)
2013
2
An adolescent presenting with malignant fibrous histiocytoma of the testis: a case report. (23347569)
2013
3
Primary malignant fibrous histiocytoma of the renal pelvis: a 78-month follow-up case report. (24368887)
2013
4
A therapeutic strategy for metastatic malignant fibrous histiocytoma through mesenchymal stromal cell-mediated TRAIL production. (23108118)
2013
5
Cholesterotic Fibrous Histiocytoma. (23518637)
2013
6
Malignant fibrous histiocytoma of the breast in young male patient: a case report and a review of the literature. (23573437)
2013
7
Mediastinal epithelioid hemangioendothelioma with abundant spindle cells and osteoclast-like giant cells mimicking malignant fibrous histiocytoma. (23800015)
2013
8
Malignant fibrous histiocytoma at the site of an alumina-on-alumina-bearing total hip arthroplasty mimicking infected trochanteric bursitis. (21435828)
2012
9
Clinical and pathologic characteristics and surgical management of benign fibrous histiocytoma of the mandible: a case report. (22580097)
2012
10
Benign fibrous histiocytoma of vulva: rare case. (24293888)
2012
11
A p53 gene mutation in malignant fibrous histiocytoma associated with bone infarction. (22041521)
2011
12
Malignant fibrous histiocytoma two years after autologous stem cell transplant for Hodgkin lymphoma: evidence for genomic instability. (21488163)
2011
13
Primary hepatic malignant fibrous histiocytoma: diagnostic pitfalls and therapeutic challenge. (21830410)
2011
14
Benign fibrous histiocytoma of bone in a paediatric population: a report of 6 cases. (21409501)
2011
15
Phase II study of sunitinib malate, a multitargeted tyrosine kinase inhibitor in patients with relapsed or refractory soft tissue sarcomas. Focus on three prevalent histologies: leiomyosarcoma, liposarcoma and malignant fibrous histiocytoma. (21154746)
2011
16
Malignant fibrous histiocytoma of the small bowel with colon metastasis. (21590606)
2011
17
Piezoelectric-assisted removal of a benign fibrous histiocytoma of the mandible: an innovative technique for prevention of dentoalveolar nerve injury. (22040611)
2011
18
Pleomorphic malignant fibrous histiocytoma/undifferentiated high-grade pleomorphic sarcoma of the scrotum in a patient presenting as fournier gangrene: a case report. (20505510)
2010
19
An angiomatoid fibrous histiocytoma over the left pre auricular region in a 13-year-old boy. (20492821)
2010
20
A rare clinical presentation of a malignant fibrous histiocytoma within the iliopsoas muscle. (20056053)
2010
21
Cardiac metastasis in malignant fibrous histiocytoma. (18626538)
2008
22
Prognostic significance of ezrin expression in pleomorphic malignant fibrous histiocytoma. (17465259)
2007
23
Squamous epithelial-lined cyst occurring in an aneurysmal fibrous histiocytoma. (17519635)
2007
24
Benign fibrous histiocytoma associated with a frontoethmoidal mucopyocele and orbital abscess. (17519668)
2007
25
Malignant fibrous histiocytoma of the parotid gland. (18188922)
2007
26
Fibrous Histiocytoma-like Spindle-Cell Proliferation in the Nipple After Body-Piercing. (16501844)
2006
27
Angiomatoid variant of fibrous histiocytoma: a case report and review of literature. (16879335)
2006
28
Diaphyseal medullary stenosis with pleomorphic malignant fibrous histiocytoma of the bone: 99mTc hydroxymethylenediphosphonate and 201Tl chloride scintigraphy findings. (16715956)
2006
29
Aneurysmal fibrous histiocytoma of the skin: a rare variant of dermatofibroma. (16327640)
2005
30
Primary malignant fibrous histiocytoma of the pancreas: a case with K-ras mutation and a review of the literature. (16416164)
2005
31
Primary malignant fibrous histiocytoma of the jejunum metastatic to the spine: report of a case. (15879629)
2005
32
Malignant fibrous histiocytoma arising from the renal capsule. (16327309)
2005
33
Malignant fibrous histiocytoma, malignant melanoma and squamous cell carcinoma arising from different areas in an adult. (16440931)
2005
34
Expression of matrix metalloproteinase-9 correlates with poor prognosis in human malignant fibrous histiocytoma. (20368833)
2004
35
Malignant fibrous histiocytoma in a chronic burn scar: a rare case report and review of the literature. (15475153)
2004
36
Evaluation of immunohistochemical parameters as prognostic markers in malignant fibrous histiocytoma. (12883752)
2003
37
Clinicopathologic features, diagnosis, and treatment of malignant fibrous histiocytoma of bone. (10642003)
2000
38
Genetic characterization of angiomatoid fibrous histiocytoma identifies fusion of the FUS and ATF-1 genes induced by a chromosomal translocation involving bands 12q13 and 16p11. (11063792)
2000
39
Dedifferentiated liposarcoma with an inflammatory malignant fibrous histiocytoma-like component presenting a leukemoid reaction. (9311018)
1997
40
Cutaneous fibrous histiocytoma with osteoclast-like giant cells. (8863988)
1996
41
P-53 positivity and high proliferative index: factors of bad prognosis in malignant fibrous histiocytomas. (8900926)
1995
42
Palisading cutaneous fibrous histiocytoma. An immunohistochemical study demonstrating differentiation from dermal dendrocytes. (8311187)
1993
43
Phenotypic characterization of the human fibrous histiocytoma giant cell tumor (GCT) cell line and its cytokine repertoire. (7689482)
1993
44
p53 immunohistochemistry in malignant fibrous histiocytomas and other mesenchymal tumours. (1333524)
1992
45
Malignant fibrous histiocytomas in dogs and cats: an immunohistochemical study. (1332152)
1992
46
T-cell lymphoma, tropical spastic paraparesis, and malignant fibrous histiocytoma in a patient with human T-cell lymphotropic virus, type 1. (2536259)
1989
47
Chemotherapy-induced complete remission of a malignant fibrous histiocytoma of bone. An 11-year follow-up. (3008679)
1986
48
Postradiation malignant fibrous histiocytoma of bone. A clinicopathologic study of 20 patients. (3006524)
1986
49
A study on the osseous elements in malignant fibrous histiocytoma of bone. (2989393)
1985
50
Malignant fibrous histiocytoma of bone. (6262217)
1980

Variations for Fibrous Histiocytoma

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Expression for genes affiliated with Fibrous Histiocytoma

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Fibrous Histiocytoma

Search GEO for disease gene expression data for Fibrous Histiocytoma.

Pathways for genes affiliated with Fibrous Histiocytoma

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51PathCards, 39NCBI BioSystems Database, 54QIAGEN
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Pathways related to Fibrous Histiocytoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Signaling by Aurora kinases39
Aurora C signaling39
9.8VIM, DES
2
Show member pathways
8.4MDM2, IL6R, MUC1, VIM, ATF1, DES

Compounds for genes affiliated with Fibrous Histiocytoma

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46Novoseek, 25HMDB, 12DrugBank, 3BitterDB, 52PharmGKB, 30IUPHAR, 62Tocris Bioscience
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Compounds related to Fibrous Histiocytoma according to GeneCards/GeneDecks:

(show top 50)    (show all 65)
idCompoundScoreTop Affiliating Genes
1orcein4610.1DES, VIM
2eosin469.9MUC1, VIM
3procollagen469.8DES, F13A1, VIM
4silver469.8SERPINA3, F13A1, DES
5mucicarmine469.8MUC1, VIM, DES
6progestin469.6DES, VIM, MUC1
7biotin46 25 1211.6MUC1, VIM, DES
8azathioprine46 3 52 1212.6MYOD1, VIM, DES
9toluidine469.5VIM, DES
10s 100469.5DES, F13A1, VIM, MUC1
11reticulin469.5MUC1, VIM, F13A1, DES
12b 723469.5DES, F13A1, VIM, MUC1
13hematoxylin469.5DES, F13A1, VIM, MUC1
14gold469.5MUC1, SERPINA3, DES
15fibrinogen469.5DES, F13A1, SERPINA3, IL6R
16adriamycin469.4DES, VIM, MUC1, MDM2
17hyaluronic acid46 2510.4MUC1, VIM, DES
18bromodeoxyuridine469.3DES, VIM, MYOD1
19dihydrotestosterone46 30 25 1212.3MUC1, VIM, DES
20thymidine46 2510.2DES, MUC1, IL6R, MDM2
21acetylcholine46 52 30 25 1213.2MYOD1, VIM, SERPINA3, DES
22heparin46 30 25 1212.2VIM, SERPINA3, F13A1, DES
23iron46 2510.2MDM2, VIM, SERPINA3, F13A1, DES
24butyrate469.1VIM, MYOD1, MUC1, IL6R
25glycogen46 2510.1DES, VIM, MUC1, IL6R, MDM2
26lysine469.1DES, F13A1, VIM, MYOD1, MDM2
27leucine469.0ATF1, SERPINA3, VIM, MYOD1
28methotrexate52 46 1211.0SERPINA3, VIM, MUC1, IL6R, MDM2
29actinomycin d468.9DES, VIM, MYOD1, MUC1, MDM2
30dexamethasone46 52 30 1211.9MDM2, IL6R, MUC1, VIM, SERPINA3
31threonine468.8MDM2, MUC1, MYOD1, SERPINA3, DES
32steroid468.7DES, ATF1, SERPINA3, MYOD1, IL6R, MDM2
33oxygen46 259.7DES, SERPINA3, MYOD1, MUC1, MDM2
34estradiol46 25 1210.7DES, SERPINA3, VIM, MUC1, IL6R, MDM2
35cyclic amp46 259.7DES, ATF1, VIM, MYOD1, MUC1, MDM2
3612-o-tetradecanoylphorbol 13-acetate468.7DES, ATF1, VIM, MYOD1, MUC1, IL6R
37arginine468.6DES, SERPINA3, VIM, MYOD1, IL6R, MDM2
38testosterone46 62 25 1211.6DES, VIM, MYOD1, MUC1, IL6R, MDM2
39glucose468.5DES, ATF1, SERPINA3, MYOD1, MUC1, IL6R
40creatinine468.5DES, SERPINA3, VIM, MYOD1, MUC1, IL6R
41cysteine468.5DES, SERPINA3, VIM, MYOD1, MUC1, MDM2
42retinoic acid46 259.5DES, SERPINA3, VIM, MYOD1, MUC1, IL6R
43oligonucleotide468.4ATF1, F13A1, SERPINA3, VIM, MYOD1, IL6R
44vegf468.3DES, F13A1, VIM, MYOD1, MUC1, IL6R
45tyrosine468.2HAVCR1, DES, MYOD1, MUC1, IL6R, MDM2
46estrogen468.2DES, F13A1, SERPINA3, VIM, MYOD1, MUC1
47serine468.2DES, ATF1, SERPINA3, VIM, MYOD1, MUC1
48progesterone46 30 62 25 1212.2DES, ATF1, F13A1, SERPINA3, VIM, MUC1
49calcium46 52 25 1211.0DES, ATF1, F13A1, SERPINA3, MYOD1, MUC1
50paraffin467.4CD68, DES, F13A1, SERPINA3, VIM, MYOD1

GO Terms for genes affiliated with Fibrous Histiocytoma

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17Gene Ontology
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Biological processes related to Fibrous Histiocytoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1muscle filament slidingGO:0300499.8VIM, DES
2acute-phase responseGO:0069539.4IL6R, SERPINA3

Molecular functions related to Fibrous Histiocytoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1scaffold protein bindingGO:0971109.8MDM2, VIM
2protein bindingGO:0055156.6MDM2, DES, ATF1, MFHAS1, SERPINA3, VIM

Products for genes affiliated with Fibrous Histiocytoma

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Sources for Fibrous Histiocytoma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet