MCID: FBR003
MIFTS: 54

Fibrous Histiocytoma malady

Summaries for Fibrous Histiocytoma

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64Wikipedia, 33MalaCards
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Wikipedia:64 Benign fibrous histiocytomas (also known as \"Dermal dendrocytoma,\" \"Dermatofibroma,\" \"Fibrous... more...

MalaCards: Fibrous Histiocytoma, also known as cutaneous fibrous histiocytoma, is related to cutaneous fibrous histiocytoma and dermatofibrosarcoma protuberans. An important gene associated with Fibrous Histiocytoma is ATF1 (activating transcription factor 1), and among its related pathways is C-MYB transcription factor network. The compounds progesterone and paraffin have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, lymph node and spleen, and related mouse phenotypes are cardiovascular system and normal.

Aliases & Classifications for Fibrous Histiocytoma

Sources:
8Disease Ontology, 10DISEASES, 61UMLS, 45Novoseek, 57SNOMED-CT, 40NCIt, 35MeSH
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Aliases & Descriptions:

fibrous histiocytoma 8 10
cutaneous fibrous histiocytoma 61
histiocytoma, benign fibrous 61
benign fibrous histiocytoma 8
fibrous histiocytoma nos 8
histiocytoma fibrous 45
fibroxanthoma nos 8


External Ids:

Disease Ontology8 DOID:4415
NCIt40 C3739
MeSH35 D018219

Related Diseases for Fibrous Histiocytoma

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Fibrous Histiocytoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 193)
idRelated DiseaseScoreTop Affiliating Genes
1cutaneous fibrous histiocytoma31.3S100A1, F13A1, DES, CD34, MMP11
2dermatofibrosarcoma protuberans30.7VIM, S100A1, F13A1, DES, CD34, MMP11
3dermatofibrosarcoma30.7FOXO4, MDM2
4dedifferentiated liposarcoma30.7DES, MDM2
5squamous cell carcinoma30.5FOXO4
6myxoid liposarcoma30.5MDM2, ATF1
7adenocarcinoma30.4VIM, MDM2, F13A1, CD34, MMP11, EREG
8angiosarcoma30.4VIM, CD34, SERPINA3
9rhabdoid tumor30.4VIM, DES, MYOD1
10spindle cell sarcoma30.4VIM, DES
11fibromatosis30.1VIM, S100A1, DES, CD34
12colorectal cancer30.1MDM2, CD34, IL6R, MMP11, EREG
13acute leukemia30.1IL6R, CD34, FOXO4
14hemangioendothelioma30.1CD34
15pleomorphic malignant fibrous histiocytoma10.9
16diaphyseal medullary stenosis with malignant fibrous histiocytoma10.7
17bone osteosarcoma10.6
18pleomorphic undifferentiated sarcoma10.6
19soft tissue sarcoma10.6
20burn scar10.5
21benign deep fibrous histiocytoma10.5
22malignant skin fibrous histiocytoma10.5
23leukemoid reaction10.5
24fibrous meningioma10.4
25malignant fibrous histiocytoma of bone10.3
26malignant histiocytosis10.3
27myxofibrosarcoma10.3
28neurofibromatosis10.3
29tenosynovial giant cell tumor10.3
30meningothelial meningioma10.3
31pleomorphic liposarcoma10.3
32inflammatory liposarcoma10.3
33hypoglycemia10.3
34fibrous dysplasia10.3
35desmoid tumor10.3
36enchondroma10.3
37gout10.1
38cardiac tamponade10.1
39eosinophilia-myalgia syndrome10.1
40anuria10.1
41chondroblastoma10.1
42pigmented villonodular synovitis10.1
43rothmund-thomson syndrome10.1
44congenital ichthyosiform erythroderma10.1
45tropical spastic paraparesis10.1
46bilateral retinoblastoma10.1
47tuberous sclerosis10.1
48cutaneous paget's disease10.1
49breast medullary carcinoma10.1
50ectomesenchymoma10.1

Graphical network of the top 20 diseases related to Fibrous Histiocytoma:



Diseases related to fibrous histiocytoma

Clinical Features for Fibrous Histiocytoma

Drugs & Therapeutics for Fibrous Histiocytoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Fibrous Histiocytoma

Drug clinical trials:

Search ClinicalTrials for Fibrous Histiocytoma

Search NIH Clinical Center for Fibrous Histiocytoma

Search CenterWatch for Fibrous Histiocytoma

Genetic Tests for Fibrous Histiocytoma

Anatomical Context for Fibrous Histiocytoma

Sources:
33MalaCards
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MalaCards organs/tissues related to Fibrous Histiocytoma:

33
Bone marrow, Lymph node, Spleen, Thymus, Brain, Heart, Smooth muscle, Skeletal muscle, Small intestine, Colon, Kidney, Liver, Lung, Pancreas, Thyroid, Adrenal gland, Breast, Skin, Ovary, Uterus, Prostate, Testis, Cervix, Monocytes, T cells, Endothelial, Tongue, Trachea, Testis germ

Animal Models for Fibrous Histiocytoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Fibrous Histiocytoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538510.6MMP11, MYOD1, DES, F13A1, MDM2, S100A1
2MP:000287310.5EREG, IL6R, MYOG, MYOD1, ATF1, MDM2
3MP:000536910.2HSPB2, MDM2, MYOD1

Publications for Fibrous Histiocytoma

Sources:
51PubMed
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Articles related to Fibrous Histiocytoma:

(show top 50)    (show all 722)
idTitleAuthorsYear
1
Primary malignant fibrous histiocytoma of the breast: report of one case. (23589696)
2013
2
Adrenal metastases in a post-radiation malignant fibrous histiocytoma after low-dose radiation for a benign condition. (23878485)
2013
3
Malignant fibrous histiocytoma of the spleen: an extremely rare entity. (22531528)
2012
4
Pulmonary artery sarcoma with angiosarcoma phenotype mimicking pleomorphic malignant fibrous histiocytoma: a case report. (23134683)
2012
5
Oral fibrous histiocytoma and its angiomatoid variant. (21875810)
2012
6
Intracardiac malignant fibrous histiocytoma. A case report. (22644015)
2012
7
Angiomatoid fibrous histiocytoma: pleomorphic variant associated with multiplication of EWSR1-CREB1 fusion gene. (22038502)
2012
8
Phase II study of sunitinib malate, a multitargeted tyrosine kinase inhibitor in patients with relapsed or refractory soft tissue sarcomas. Focus on three prevalent histologies: leiomyosarcoma, liposarcoma and malignant fibrous histiocytoma. (21154746)
2011
9
Reticular angiomatoid "malignant" fibrous histiocytoma--a case report with cytogenetics and molecular genetic analyses. (21411119)
2011
10
Malignant fibrous histiocytoma of the urinary bladder as a post-radiation secondary cancer: a case report. (22074680)
2011
11
A Case Report of a Malignant Fibrous Histiocytoma in a T-cell Receptor I^ Chain and p53 Double-knockout Mouse. (22319239)
2011
12
Lipidized fibrous histiocytoma on the left condyle of the tibia. (21506990)
2011
13
Malignant fibrous histiocytoma arising from the omentum presenting as hemoperitoneum. (20559528)
2010
14
A case of multiple benign fibrous histiocytoma with indeterminate cells and eosinophils. (20202056)
2010
15
Benign fibrous histiocytoma (dermatofibroma) of the face: a rare entity requiring aggressive surgical management. (20378438)
2010
16
Fine needle aspiration cytology of benign fibrous histiocytoma of bone: a case report. (20306998)
2010
17
Malignant fibrous histiocytoma--a rare hepatic tumor. (20361853)
2010
18
Angiomatoid fibrous histiocytoma in a 25-year-old male. (21139823)
2010
19
Primary malignant fibrous histiocytoma of the spleen--an extremely rare entity. (21158336)
2010
20
Cutaneous malignant fibrous histiocytoma (undifferentiated pleomorphic sarcoma) arising in a chronic scalp ulcer of a patient with non-bullous congenital ichthyosiform erythroderma. (18435726)
2009
21
Right hemi-reconstruction of the left atrium using two equine pericardial patches for recurrent malignant fibrous histiocytoma: report of a case. (19639440)
2009
22
Malignant fibrous histiocytoma of the sinonasal tract. (18853446)
2009
23
A rare case of malignant fibrous histiocytoma of the gingiva. (18454677)
2008
24
Angiomatoid fibrous histiocytoma: a review with recent genetic findings. (18251589)
2008
25
Low-grade, aggressive fibrous histiocytoma of the medial canthus. (18347642)
2008
26
Malignant fibrous histiocytoma of the parotid gland. (18188922)
2007
27
Primary malignant fibrous histiocytoma of the heart with skeletal muscles metastases. (18039217)
2007
28
Fibrous Histiocytoma-like Spindle-Cell Proliferation in the Nipple After Body-Piercing. (16501844)
2006
29
Angiomatoid variant of fibrous histiocytoma: a case report and review of literature. (16879335)
2006
30
CD99 immunoreactivity in atypical fibroxanthoma and pleomorphic malignant fibrous histiocytoma: a useful diagnostic marker. (16972949)
2006
31
HLA-restricted specific tumor cytolysis by autologous T-lymphocytes infiltrating metastatic bone malignant fibrous histiocytoma of lymph node. (16419974)
2006
32
Malignant fibrous histiocytoma: outcome of tumours in the head and neck compared with those in the trunk and extremities. (16026908)
2006
33
Tandem high-dose chemotherapy supported by autologous peripheral blood stem-cell transplantation and radiotherapy for recurrent malignant fibrous histiocytoma. (16437321)
2005
34
Malignant fibrous histiocytoma of the pharynx. (15728001)
2005
35
Can pancreaticoduodenectomy be used to palliate selective metastatic malignancies? Case report of malignant fibrous histiocytoma. (16137587)
2005
36
CASE REPORTS: malignant fibrous histiocytoma of bone arising in chronic osteomyelitis. (16205169)
2005
37
Abdominal aorta and inferior vena cava thromboses in advanced stage of malignant fibrous histiocytoma. (16570715)
2005
38
Malignant fibrous histiocytoma in a chronic burn scar: a rare case report and review of the literature. (15475153)
2004
39
Recurrent primary cardiac malignant fibrous histiocytoma following orthotopic heart transplantation. (15607678)
2004
40
Malignant fibrous histiocytoma metastatic to adrenal gland: a case report. (17385836)
2004
41
Molecular analysis of p53, MDM2, and H-ras genes in osteosarcoma and malignant fibrous histiocytoma of bone in patients older than 40 years. (12181274)
2002
42
Immunohistochemical status of p53, mdm2 and Ki-67 in malignant fibrous histiocytoma. (9640970)
1998
43
Cutaneous fibrous histiocytoma with osteoclast-like giant cells. (8863988)
1996
44
Malignant fibrous histiocytoma of bone - Review of thirteen cases. (21594458)
1996
45
No rearrangements of the CHOP gene in malignant fibrous histiocytoma. (8143276)
1994
46
Palisading cutaneous fibrous histiocytoma. An immunohistochemical study demonstrating differentiation from dermal dendrocytes. (8311187)
1993
47
Pleural malignant fibrous histiocytoma concomitant with pulmonary adenocarcinoma. (1335205)
1992
48
Malignant fibrous histiocytoma of bone: initial diagnosis by aspiration biopsy cytology. (2855512)
1988
49
Pleomorphic xanthoastrocytoma. Immunohistochemical methods for differentiation from fibrous histiocytomas with similar morphology. (3010749)
1986
50
Malignant (fibrous) histiocytoma of bone--fact or fancy?. (192432)
1977

Genetic Variations for Fibrous Histiocytoma

Expression for genes affiliated with Fibrous Histiocytoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Fibrous Histiocytoma

Search GEO for disease gene expression data for Fibrous Histiocytoma.

Pathways for genes affiliated with Fibrous Histiocytoma

Sources:
38NCBI BioSystems Database
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Pathways related to Fibrous Histiocytoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.5LYZ, CD34, MYOD1

Compounds for genes affiliated with Fibrous Histiocytoma

Sources:
45Novoseek, 60Tocris Bioscience, 29IUPHAR, 11DrugBank, 24HMDB, 50PharmGKB, 2BitterDB
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Compounds related to Fibrous Histiocytoma according to GeneCards/GeneDecks:

(show all 48)
idCompoundScoreTop Affiliating Genes
1progesterone45 60 29 11 2415.1F13A1, ATF1, MDM2, S100A1, VIM, DES
2paraffin4511.1SERPINA3, VIM, S100A1, MDM2, F13A1, DES
3calcium45 50 11 2414.1HSPB2, S100A1, MDM2, ATF1, F13A1, DES
4oligonucleotide4511.1VIM, HSPB2, MDM2, ATF1, F13A1, MYOD1
5vegf4511.1F13A1, MDM2, HSPB2, VIM, DES, MYOD1
612-o-tetradecanoylphorbol 13-acetate4511.1VIM, HSPB2, ATF1, DES, MYOD1, MYOG
7steroid4511.1MDM2, ATF1, DES, MYOD1, MYOG, IL6R
8arginine4511.0VIM, HSPB2, MDM2, DES, MYOD1, IL6R
9retinoic acid45 2412.0VIM, S100A1, DES, MYOD1, MYOG, CD34
10iron45 2412.0VIM, HSPB2, S100A1, MDM2, F13A1, DES
11acetylcholine45 50 29 11 2415.0VIM, HSPB2, S100A1, DES, MYOD1, MYOG
12testosterone45 60 11 2414.0VIM, MDM2, DES, MYOD1, MYOG, IL6R
13hematoxylin4511.0VIM, S100A1, F13A1, DES, CD34
14cysteine4511.0VIM, S100A1, MDM2, DES, MYOD1, MYOG
15silver4511.0S100A1, F13A1, DES, CD34, SERPINA3
16reticulin4511.0VIM, F13A1, DES, CD34
17estrogen4511.0F13A1, MYOD1, MYOG
18b 7234511.0VIM, S100A1, F13A1, DES
19lysine4510.9VIM, HSPB2, MDM2, F13A1, DES, MYOD1
20tyrosine4510.9HSPB2, S100A1, MDM2, DES, MYOD1, MYOG
21creatinine4510.9HSPB2, MYOD1, IL6R, SERPINA3
22nacl4510.9HSPB2, S100A1, DES, SERPINA3, LYZ
23s 1004510.9DES, F13A1, VIM
24serine4510.9HSPB2, ATF1, DES, MYOD1, MYOG, SERPINA3
25glycogen45 2411.9FOXO4, MDM2, IL6R
26oxygen45 2411.9HSPB2, MDM2, DES, MYOD1, MYOG, MMP11
27heparin45 29 11 2413.9F13A1, DES, B3GAT1, SERPINA3
28toluidine4510.9DES, S100A1, VIM
29mucicarmine4510.9VIM, S100A1, DES
30estradiol45 11 2412.9VIM, MDM2, DES, IL6R, SERPINA3
31bromodeoxyuridine4510.9VIM, DES, MYOD1, MYOG
32zinc45 2411.9S100A1, MDM2, MYOD1, IL6R, MMP11, SERPINA3
33glucose4510.8SERPINA3, IL6R, MYOG
34methotrexate45 50 1112.8SERPINA3, IL6R, MDM2, VIM
35cyclic amp45 2411.8VIM, MDM2, ATF1, DES, MYOD1
36rubin4510.8SERPINA3, B3GAT1
37polyacrylamide4510.8SERPINA3, DES, F13A1, HSPB2
38orcein4510.8VIM, DES
39gefitinib45 50 1112.7EREG, MDM2, VIM
40procollagen4510.7F13A1
41fibrinogen4510.7SERPINA3, IL6R, DES, F13A1
42butyrate4510.7MYOD1, MYOG
432-methoxyethanol4510.6S100A1, VIM
44azathioprine45 50 2 1113.6VIM, DES, MYOD1
45wortmannin4510.6IL6R, MDM2, FOXO4, VIM
46biotin45 11 2412.5DES, S100A1, VIM
47pd 98,0594510.4HSPB2, MDM2, ATF1, MYOG
48vincristine45 50 1112.2MDM2, HSPB2, VIM

GO Terms for genes affiliated with Fibrous Histiocytoma

Sources:
16Gene Ontology
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Biological processes related to Fibrous Histiocytoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of smooth muscle cell differentiationGO:05115110.6EREG, FOXO4
2muscle cell fate commitmentGO:04269310.5MYOG, MYOD1
3cellular response to estradiol stimulusGO:07139210.5MYOG, MYOD1
4neurotrophin TRK receptor signaling pathwayGO:04801110.4FOXO4, MDM2, ATF1, EREG
5skeletal muscle fiber developmentGO:04874110.2MYOG, MYOD1

Molecular functions related to Fibrous Histiocytoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1identical protein bindingGO:04280210.6LYZ, DES, MDM2, S100A1, VIM

Products for genes affiliated with Fibrous Histiocytoma

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Sources for Fibrous Histiocytoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet