MCID: FBR003
MIFTS: 55

Fibrous Histiocytoma malady

Summaries for Fibrous Histiocytoma

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63Wikipedia, 32MalaCards
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Wikipedia:63 Benign fibrous histiocytomas (also known as \"Dermal dendrocytoma,\" \"Dermatofibroma,\" \"Fibrous... more...

MalaCards: Fibrous Histiocytoma, also known as cutaneous fibrous histiocytoma, is related to cutaneous fibrous histiocytoma and sarcoma. An important gene associated with Fibrous Histiocytoma is ATF1 (activating transcription factor 1), and among its related pathways is C-MYB transcription factor network. The compounds progesterone and paraffin have been mentioned in the context of this disorder. Affiliated tissues include bone, skin and breast, and related mouse phenotypes are cardiovascular system and normal.

Aliases & Classifications for Fibrous Histiocytoma

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH
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Aliases & Descriptions:

fibrous histiocytoma 8 10
cutaneous fibrous histiocytoma 60
histiocytoma, benign fibrous 60
benign fibrous histiocytoma 8
fibrous histiocytoma nos 8
histiocytoma fibrous 44
fibroxanthoma nos 8


External Ids:

Disease Ontology8 DOID:4415
NCIt39 C3739
MeSH34 D018219

Related Diseases for Fibrous Histiocytoma

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17GeneCards, 18GeneDecks
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Diseases related to Fibrous Histiocytoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 209)
idRelated DiseaseScoreTop Affiliating Genes
1cutaneous fibrous histiocytoma31.3S100A1, F13A1, DES, CD34, MMP11
2sarcoma31.2MYOD1, MYOG, CD34, B3GAT1, MMP11, LYZ
3malignant fibroxanthoma31.0FOXO4, MFHAS1, CD34, LYZ
4osteosarcoma30.9IL6R, MYOD1, MDM2
5liposarcoma30.9VIM, MDM2, DES, CD34
6fibrosarcoma30.7CD34, DES, MDM2, VIM
7dermatofibrosarcoma30.7FOXO4, MDM2
8leiomyosarcoma30.6MYOD1, MYOG, CD34, DES, MDM2, VIM
9meningioma30.5VIM, S100A1, CD68, CD34
10epithelioid sarcoma30.5VIM, CD34
11leukemia30.4MDM2, ATF1, CD34, IL6R, B3GAT1, SERPINA3
12giant cell tumor30.4VIM, F13A1, DES, SERPINA3
13histiocytosis30.4LYZ, CD68
14squamous cell carcinoma30.4FOXO4
15retinoblastoma30.4MDM2, MYOD1, MYOG
16myxoid liposarcoma30.4MDM2, ATF1
17melanoma30.3VIM, HSPB2, S100A1, FOXO4, MDM2, ATF1
18hemangiopericytoma30.3VIM, S100A1, MDM2, F13A1, DES, CD34
19adenocarcinoma30.3VIM, MDM2, F13A1, CD34, MMP11, EREG
20angiosarcoma30.3VIM, CD34, SERPINA3
21hepatocellular carcinoma30.3MDM2, ATF1, F13A1, CD34, IL6R
22chordoma30.3VIM, S100A1, DES
23hemangioma30.3F13A1, CD68, CD34
24spindle cell sarcoma30.3VIM, DES
25leiomyoma30.1VIM, S100A1, DES, MYOG, CD34
26rhabdomyosarcoma30.1VIM, S100A1, MDM2, DES, MYOD1, MYOG
27colorectal cancer30.1MDM2, CD34, IL6R, MMP11, EREG
28acute leukemia30.1IL6R, CD34, FOXO4
29langerhans-cell histiocytosis30.1S100A1, F13A1
30non-hodgkin lymphoma30.1IL6R, CD34, MYOD1, MDM2
31pulmonary embolism30.1F13A1
32meningitis30.1LYZ
33histiocytoma11.5
34malignant fibrous histiocytoma of bone11.0
35diaphyseal medullary stenosis with malignant fibrous histiocytoma10.7
36bone osteosarcoma10.6
37hepatitis10.6
38hepatitis a10.5
39burn scar10.5
40burns10.5
41malignant skin fibrous histiocytoma10.4
42leukemoid reaction10.4
43benign deep fibrous histiocytoma10.4
44thyroiditis10.4
45fibrous meningioma10.4
46sclerosing hemangioma10.4
47pleomorphic malignant fibrous histiocytoma10.4
48fibrosarcoma of bone10.3
49cerebritis10.3
50malignant histiocytosis10.3

Graphical network of the top 20 diseases related to Fibrous Histiocytoma:



Diseases related to fibrous histiocytoma

Clinical Features for Fibrous Histiocytoma

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Drugs & Therapeutics for Fibrous Histiocytoma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

Search ClinicalTrials for Fibrous Histiocytoma

Search NIH Clinical Center for Fibrous Histiocytoma

Search CenterWatch for Fibrous Histiocytoma

Genetic Tests for Fibrous Histiocytoma

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Anatomical Context for Fibrous Histiocytoma

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32MalaCards
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MalaCards organs/tissues related to Fibrous Histiocytoma:

32
Bone, Skin, Breast, Lung, Heart, Liver, Spleen, Pancreas, Colon, Kidney, Ovary, Thyroid, Cervix, T cells, Trachea, Tongue, Smooth muscle, Thymus, Prostate, Adrenal gland, Brain, Lymph node, Skeletal muscle, Endothelial, Uterus, Monocytes, Testis, Bone marrow, Testes

Animal Models for Fibrous Histiocytoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Fibrous Histiocytoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538510.6MMP11, MYOD1, DES, F13A1, MDM2, S100A1
2MP:000287310.5EREG, IL6R, MYOG, MYOD1, ATF1, MDM2
3MP:000536910.2HSPB2, MDM2, MYOD1

Publications for Fibrous Histiocytoma

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50PubMed
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Articles related to Fibrous Histiocytoma:

(show top 50)    (show all 722)
idTitleAuthorsYear
1
Endobronchial malignant fibrous histiocytoma: case report of an unusual presentation and palliative flexible bronchoscopic resection. (23258577)
2013
2
Retroperitoneal angiomatoid fibrous histiocytoma: A case report and review of the literature. (23833650)
2013
3
Malignant fibrous histiocytoma of the diaphragm. (23317589)
2013
4
Identification of APN/CD13 as the target antigen of FU3, a human monoclonal antibody that recognizes malignant fibrous histiocytoma. (23677132)
2013
5
Benign fibrous histiocytoma of the cheek. (23218719)
2013
6
'Decoy' and 'non-decoy' functions of DcR3 promote malignant potential in human malignant fibrous histiocytoma cells. (23817777)
2013
7
Desmin and CD34 positivity in cellular fibrous histiocytoma: an immunohistochemical analysis of 100 cases. (22775584)
2012
8
Primary intracerebral malignant fibrous histiocytoma mimicking a meningioma. (22843469)
2012
9
Angiomatoid fibrous histiocytoma: a case report and review of the literature. (23372863)
2012
10
Malignant fibrous histiocytoma arising from a hydronephrotic kidney: a case report and review of the literature. (22542387)
2012
11
A p53 gene mutation in malignant fibrous histiocytoma associated with bone infarction. (22041521)
2011
12
Malignant fibrous histiocytoma masquerading as gluteal abscess. (22202512)
2011
13
Primary malignant fibrous histiocytoma of the liver: CT findings in five histopathological proven patients. (21287171)
2011
14
The expression of c-Met pathway components in unclassified pleomorphic sarcoma/malignant fibrous histiocytoma (UPS/MFH): a tissue microarray study. (22034893)
2011
15
Angiomatoid fibrous histiocytoma including cases with pleomorphic features analysed by fluorescence in situ hybridisation. (20154033)
2010
16
Angiomatoid fibrous histiocytoma of bone: a calcifying sclerosing variant mimicking osteosarcoma. (20090505)
2010
17
Tyrosine kinase inhibitors in treatment of fibrous histiocytoma. (19300420)
2009
18
Chinese flap to repair a defect of a malignant fibrous histiocytoma. (18482032)
2008
19
Peritoneal dissemination from malignant fibrous histiocytoma of the buttock: unusual metastases from a rare tumor. (20485650)
2008
20
Benign fibrous histiocytoma in the condylar process of the mandible: Case report. (17561319)
2008
21
A case of radiation-induced sternal malignant fibrous histiocytoma treated with neoadjuvant chemotherapy and surgical resection. (19116008)
2008
22
Establishment of a nude mouse transplantable model of a human malignant fibrous histiocytoma of the mandible with high metastatic potential to the lung. (18317806)
2008
23
Case of primary malignant fibrous histiocytoma of the diaphragm discovered by liver function disorder]. (17230008)
2007
24
Diaphyseal medullary stenosis with pleomorphic malignant fibrous histiocytoma of the bone: 99mTc hydroxymethylenediphosphonate and 201Tl chloride scintigraphy findings. (16715956)
2006
25
Malignant fibrous histiocytoma of the chest wall masquerading as medullary breast carcinoma: a case report. (17017451)
2006
26
Expression of CD163 in dermatofibroma, cellular fibrous histiocytoma, and dermatofibrosarcoma protuberans: comparison with CD68, CD34, and Factor XIIIa. (16640542)
2006
27
Primary malignant fibrous histiocytoma of the pancreas: a case with K-ras mutation and a review of the literature. (16416164)
2005
28
Leiomyosarcoma and malignant fibrous histiocytoma share similar allelic imbalance pattern at 9p. (15731925)
2005
29
Benign fibrous histiocytoma of the mandible. (15689235)
2005
30
Postradiation malignant fibrous histiocytoma and osteosarcoma of a patient with high telomerase activities. (16080549)
2005
31
Myxofibrosarcoma (myxoid malignant fibrous histiocytoma) showing cutaneous presentation: report of two cases. (16008697)
2005
32
An autopsy case of mediastinal malignant fibrous histiocytoma completely occluding right pulmonary artery. (16186067)
2005
33
Myxofibrosarcoma of the breast as an unusual variant of malignant fibrous histiocytoma: report of a case. (15338347)
2004
34
Interleukin-6/soluble interleukin-6 receptor signaling attenuates proliferation and invasion, and induces morphological changes of a newly established pleomorphic malignant fibrous histiocytoma cell line. (15277221)
2004
35
Immunohistochemical Loss of the DNA Mismatch Repair Proteins MSH2 and MSH6 in Malignant Fibrous Histiocytomas. (18521406)
2004
36
Palisading subcutaneous fibrous histiocytoma. (15086842)
2004
37
The rise and fall of malignant fibrous histiocytoma. (15764577)
2004
38
Malignant fibrous histiocytoma arising from the renal capsule. (16222115)
2003
39
Clinicopathologic features, diagnosis, and treatment of malignant fibrous histiocytoma of bone. (10642003)
2000
40
Malignant fibrous histiocytoma of the liver]. (10768247)
2000
41
Myxoid malignant fibrous histiocytoma mimicking papular mucinosis. (9650705)
1998
42
Human malignant fibrous histiocytomas in vitro: growth characteristics and their association with expression of mRNA for platelet-derived growth factor, transforming growth factor-alpha and their receptors. (10070317)
1998
43
Dedifferentiated liposarcoma with an inflammatory malignant fibrous histiocytoma-like component presenting a leukemoid reaction. (9311018)
1997
44
Apoptosis in atypical fibroxanthoma and pleomorphic malignant fibrous histiocytoma. (9185907)
1997
45
Malignant fibrous histiocytoma of bone. A clinicopathologic study of 81 patients. (9028358)
1997
46
Prognostic implication of the p53 protein and Ki-67 antigen immunohistochemistry in malignant fibrous histiocytoma. (8625155)
1995
47
Evaluation of CD68 and other histiocytic antigens in angiomatoid malignant fibrous histiocytoma. (1676879)
1991
48
Treatment of malignant fibrous histiocytoma of bone. A plea for primary chemotherapy. (2988736)
1985
49
Malignant fibrous histiocytoma of bone. (6262217)
1980
50
Malignant fibrous histiocytoma of bone. (233365)
1978

Genetic Variations for Fibrous Histiocytoma

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Expression for genes affiliated with Fibrous Histiocytoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Fibrous Histiocytoma

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Pathways for genes affiliated with Fibrous Histiocytoma

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37NCBI BioSystems Database
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Pathways related to Fibrous Histiocytoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.5LYZ, CD34, MYOD1

Compounds for genes affiliated with Fibrous Histiocytoma

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44Novoseek, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB, 2BitterDB
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Compounds related to Fibrous Histiocytoma according to GeneCards/GeneDecks:

(show all 48)
idCompoundScoreTop Affiliating Genes
1progesterone44 59 28 11 2415.1F13A1, ATF1, MDM2, S100A1, VIM, DES
2paraffin4411.1SERPINA3, VIM, S100A1, MDM2, F13A1, DES
3calcium44 49 11 2414.1HSPB2, S100A1, MDM2, ATF1, F13A1, DES
4oligonucleotide4411.1VIM, HSPB2, MDM2, ATF1, F13A1, MYOD1
5vegf4411.1F13A1, MDM2, HSPB2, VIM, DES, MYOD1
612-o-tetradecanoylphorbol 13-acetate4411.1VIM, HSPB2, ATF1, DES, MYOD1, MYOG
7steroid4411.1MDM2, ATF1, DES, MYOD1, MYOG, IL6R
8arginine4411.0VIM, HSPB2, MDM2, DES, MYOD1, IL6R
9retinoic acid44 2412.0VIM, S100A1, DES, MYOD1, MYOG, CD34
10iron44 2412.0VIM, HSPB2, S100A1, MDM2, F13A1, DES
11acetylcholine44 49 28 11 2415.0VIM, HSPB2, S100A1, DES, MYOD1, MYOG
12testosterone44 59 11 2414.0VIM, MDM2, DES, MYOD1, MYOG, IL6R
13hematoxylin4411.0VIM, S100A1, F13A1, DES, CD34
14cysteine4411.0VIM, S100A1, MDM2, DES, MYOD1, MYOG
15silver4411.0S100A1, F13A1, DES, CD34, SERPINA3
16reticulin4411.0VIM, F13A1, DES, CD34
17estrogen4411.0F13A1, MYOD1, MYOG
18b 7234411.0VIM, S100A1, F13A1, DES
19lysine4410.9VIM, HSPB2, MDM2, F13A1, DES, MYOD1
20tyrosine4410.9HSPB2, S100A1, MDM2, DES, MYOD1, MYOG
21creatinine4410.9HSPB2, MYOD1, IL6R, SERPINA3
22nacl4410.9HSPB2, S100A1, DES, SERPINA3, LYZ
23s 1004410.9DES, F13A1, VIM
24serine4410.9HSPB2, ATF1, DES, MYOD1, MYOG, SERPINA3
25glycogen44 2411.9FOXO4, MDM2, IL6R
26oxygen44 2411.9HSPB2, MDM2, DES, MYOD1, MYOG, MMP11
27heparin44 28 11 2413.9F13A1, DES, B3GAT1, SERPINA3
28toluidine4410.9DES, S100A1, VIM
29mucicarmine4410.9VIM, S100A1, DES
30estradiol44 11 2412.9VIM, MDM2, DES, IL6R, SERPINA3
31bromodeoxyuridine4410.9VIM, DES, MYOD1, MYOG
32zinc44 2411.9S100A1, MDM2, MYOD1, IL6R, MMP11, SERPINA3
33glucose4410.8SERPINA3, IL6R, MYOG
34methotrexate44 49 1112.8SERPINA3, IL6R, MDM2, VIM
35cyclic amp44 2411.8VIM, MDM2, ATF1, DES, MYOD1
36rubin4410.8SERPINA3, B3GAT1
37polyacrylamide4410.8SERPINA3, DES, F13A1, HSPB2
38orcein4410.8VIM, DES
39gefitinib44 49 1112.7EREG, MDM2, VIM
40procollagen4410.7F13A1
41fibrinogen4410.7SERPINA3, IL6R, DES, F13A1
42butyrate4410.7MYOD1, MYOG
432-methoxyethanol4410.6S100A1, VIM
44azathioprine44 49 2 1113.6VIM, DES, MYOD1
45wortmannin4410.6IL6R, MDM2, FOXO4, VIM
46biotin44 11 2412.5DES, S100A1, VIM
47pd 98,0594410.4HSPB2, MDM2, ATF1, MYOG
48vincristine44 49 1112.2MDM2, HSPB2, VIM

GO Terms for genes affiliated with Fibrous Histiocytoma

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16Gene Ontology
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Biological processes related to Fibrous Histiocytoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of smooth muscle cell differentiationGO:05115110.6EREG, FOXO4
2muscle cell fate commitmentGO:04269310.5MYOG, MYOD1
3cellular response to estradiol stimulusGO:07139210.5MYOG, MYOD1
4neurotrophin TRK receptor signaling pathwayGO:04801110.4FOXO4, MDM2, ATF1, EREG
5skeletal muscle fiber developmentGO:04874110.2MYOG, MYOD1

Molecular functions related to Fibrous Histiocytoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1identical protein bindingGO:04280210.6LYZ, DES, MDM2, S100A1, VIM

Products for genes affiliated with Fibrous Histiocytoma

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Sources for Fibrous Histiocytoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet