MCID: FBR003
MIFTS: 55

Fibrous Histiocytoma malady

Summaries for Fibrous Histiocytoma

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63Wikipedia, 32MalaCards
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Wikipedia:63 Benign fibrous histiocytomas (also known as \"Dermal dendrocytoma,\" \"Dermatofibroma,\" \"Fibrous... more...

MalaCards: Fibrous Histiocytoma, also known as cutaneous fibrous histiocytoma, is related to cutaneous fibrous histiocytoma and sarcoma. An important gene associated with Fibrous Histiocytoma is ATF1 (activating transcription factor 1), and among its related pathways is C-MYB transcription factor network. The compounds progesterone and paraffin have been mentioned in the context of this disorder. Affiliated tissues include bone, skin and breast, and related mouse phenotypes are cardiovascular system and normal.

Aliases & Classifications for Fibrous Histiocytoma

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8Disease Ontology, 10DISEASES, 60UMLS, 44Novoseek, 56SNOMED-CT, 39NCIt, 34MeSH
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Aliases & Descriptions:

fibrous histiocytoma 8 10
cutaneous fibrous histiocytoma 60
histiocytoma, benign fibrous 60
benign fibrous histiocytoma 8
fibrous histiocytoma nos 8
histiocytoma fibrous 44
fibroxanthoma nos 8


External Ids:

Disease Ontology8 DOID:4415
NCIt39 C3739
MeSH34 D018219

Related Diseases for Fibrous Histiocytoma

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17GeneCards, 18GeneDecks
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Diseases related to Fibrous Histiocytoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 209)
idRelated DiseaseScoreTop Affiliating Genes
1cutaneous fibrous histiocytoma31.3S100A1, F13A1, DES, CD34, MMP11
2sarcoma31.2MYOD1, MYOG, CD34, B3GAT1, MMP11, LYZ
3malignant fibroxanthoma31.0FOXO4, MFHAS1, CD34, LYZ
4osteosarcoma30.9IL6R, MYOD1, MDM2
5liposarcoma30.9VIM, MDM2, DES, CD34
6fibrosarcoma30.7CD34, DES, MDM2, VIM
7dermatofibrosarcoma30.7FOXO4, MDM2
8leiomyosarcoma30.6MYOD1, MYOG, CD34, DES, MDM2, VIM
9meningioma30.5VIM, S100A1, CD68, CD34
10epithelioid sarcoma30.5VIM, CD34
11leukemia30.4MDM2, ATF1, CD34, IL6R, B3GAT1, SERPINA3
12giant cell tumor30.4VIM, F13A1, DES, SERPINA3
13histiocytosis30.4LYZ, CD68
14squamous cell carcinoma30.4FOXO4
15retinoblastoma30.4MDM2, MYOD1, MYOG
16myxoid liposarcoma30.4MDM2, ATF1
17melanoma30.3VIM, HSPB2, S100A1, FOXO4, MDM2, ATF1
18hemangiopericytoma30.3VIM, S100A1, MDM2, F13A1, DES, CD34
19adenocarcinoma30.3VIM, MDM2, F13A1, CD34, MMP11, EREG
20angiosarcoma30.3VIM, CD34, SERPINA3
21hepatocellular carcinoma30.3MDM2, ATF1, F13A1, CD34, IL6R
22chordoma30.3VIM, S100A1, DES
23hemangioma30.3F13A1, CD68, CD34
24spindle cell sarcoma30.3VIM, DES
25leiomyoma30.1VIM, S100A1, DES, MYOG, CD34
26rhabdomyosarcoma30.1VIM, S100A1, MDM2, DES, MYOD1, MYOG
27colorectal cancer30.1MDM2, CD34, IL6R, MMP11, EREG
28acute leukemia30.1IL6R, CD34, FOXO4
29langerhans-cell histiocytosis30.1S100A1, F13A1
30non-hodgkin lymphoma30.1IL6R, CD34, MYOD1, MDM2
31pulmonary embolism30.1F13A1
32meningitis30.1LYZ
33histiocytoma11.5
34malignant fibrous histiocytoma of bone11.0
35diaphyseal medullary stenosis with malignant fibrous histiocytoma10.7
36bone osteosarcoma10.6
37hepatitis10.6
38hepatitis a10.5
39burn scar10.5
40burns10.5
41malignant skin fibrous histiocytoma10.4
42leukemoid reaction10.4
43benign deep fibrous histiocytoma10.4
44thyroiditis10.4
45fibrous meningioma10.4
46sclerosing hemangioma10.4
47pleomorphic malignant fibrous histiocytoma10.4
48fibrosarcoma of bone10.3
49cerebritis10.3
50malignant histiocytosis10.3

Graphical network of the top 20 diseases related to Fibrous Histiocytoma:



Diseases related to fibrous histiocytoma

Clinical Features for Fibrous Histiocytoma

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Drugs & Therapeutics for Fibrous Histiocytoma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

Search ClinicalTrials for Fibrous Histiocytoma

Search NIH Clinical Center for Fibrous Histiocytoma

Search CenterWatch for Fibrous Histiocytoma

Genetic Tests for Fibrous Histiocytoma

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Anatomical Context for Fibrous Histiocytoma

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32MalaCards
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MalaCards organs/tissues related to Fibrous Histiocytoma:

32
Bone, Skin, Breast, Lung, Heart, Liver, Spleen, Pancreas, Colon, Kidney, Ovary, Thyroid, Cervix, T cells, Tongue, Trachea, Adrenal gland, Lymph node, Smooth muscle, Prostate, Thymus, Brain, Endothelial, Monocytes, Testes, Testis, Uterus, Skeletal muscle, Bone marrow

Animal Models for Fibrous Histiocytoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Fibrous Histiocytoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538510.6MMP11, MYOD1, DES, F13A1, MDM2, S100A1
2MP:000287310.5EREG, IL6R, MYOG, MYOD1, ATF1, MDM2
3MP:000536910.2HSPB2, MDM2, MYOD1

Publications for Fibrous Histiocytoma

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50PubMed
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Articles related to Fibrous Histiocytoma:

(show top 50)    (show all 722)
idTitleAuthorsYear
1
Mediastinal epithelioid hemangioendothelioma with abundant spindle cells and osteoclast-like giant cells mimicking malignant fibrous histiocytoma. (23800015)
2013
2
Benign fibrous histiocytoma presenting as anal canal polyp: first case report. (22999485)
2013
3
Diagnostic and therapeutic strategy and the most efficient prognostic factors of breast malignant fibrous histiocytoma. (23982330)
2013
4
Malignant fibrous histiocytoma of right atrium. (23673127)
2013
5
Malignant fibrous histiocytoma. (23729703)
2013
6
Clinical characteristics of the primary hepatic malignant fibrous histiocytoma in China: case report and review of the literature. (22221822)
2012
7
Malignant fibrous histiocytoma of the spermatic cord in a patient with polycystic kidney disease; review of the literature. (22483863)
2012
8
Autologous CTL response against cancer stem-like cells/cancer-initiating cells of bone malignant fibrous histiocytoma. (21518139)
2011
9
Is radical oncosurgery justified for the treatment of primary malignant fibrous histiocytoma of the urinary bladder? Report of two cases and analyses of disease-specific survival rates based on a review of the literature. (21266796)
2011
10
Transformation of benign fibrous histiocytoma into malignant fibrous histiocytoma in the mandible: case report. (21549470)
2011
11
Secondary malignant fibrous histiocytoma of thigh with surface ulceration following radiotherapy for carcinoma cervix. (20922400)
2011
12
Protein kinase CI' in tumorigenesis of human malignant fibrous histiocytoma. (21822543)
2011
13
Malignant fibrous histiocytoma of the kidney treated with nephrectomy and adjuvant radiotherapy: a case report. (20936124)
2010
14
Surgical treatment of benign fibrous histiocytoma as a form of intraspinal extradural tumor at lumbar spine. (21165318)
2010
15
A case of malignant fibrous histiocytoma of the maxillary sinus. (20219594)
2010
16
A rare case of cystic variety of angiomatoid fibrous histiocytoma. (21222377)
2010
17
Aneurysmal benign fibrous histiocytoma with atrophic features. (20548854)
2009
18
Benign fibrous histiocytoma of the hand: a case report and literature review. (19054841)
2008
19
Prognostic significance of ezrin expression in pleomorphic malignant fibrous histiocytoma. (17465259)
2007
20
Benign fibrous histiocytoma associated with a frontoethmoidal mucopyocele and orbital abscess. (17519668)
2007
21
Metastatic gastric cancer from malignant fibrous histiocytoma: report of a case. (16554998)
2006
22
Cardiac metastases in malignant fibrous histiocytoma. A case report. (16683388)
2006
23
Intra-articular benign fibrous histiocytoma in the knee joint. (16126391)
2006
24
Malignant fibrous histiocytoma of the common hepatic duct: a case report. (17082693)
2006
25
Malignant fibrous histiocytoma of the mandible. (16549441)
2006
26
Adult paratesticular malignant fibrous histiocytoma treated with surgery, systemic chemotherapy and postoperative adjuvant radiotherapy. (17998705)
2006
27
Primary malignant fibrous histiocytoma of the small bowel: a report of an additional case in duodenum. (16648661)
2005
28
Malignant fibrous histiocytoma: pleomorphic sarcoma NOS or pleomorphic fibrosarcoma]. (15702318)
2005
29
Benign fibrous histiocytoma of the sacrum--diagnostic difficulties facing this rare bone tumor. (16195678)
2005
30
Pulmonary resection for metastatic malignant fibrous histiocytoma: an analysis of prognostic factors. (16242467)
2005
31
Fine-needle aspiration of primary and recurrent benign fibrous histiocytoma: classic, aneurysmal, and myxoid variants. (15540171)
2004
32
A case of atypical benign fibrous histiocytoma. (15473340)
2004
33
Malignant fibrous histiocytoma (inflammatory variant) in a child presenting as paraparesis. (16137168)
2004
34
Genetic analysis of fibrosarcoma of bone, a rare tumour entity closely related to osteosarcoma and malignant fibrous histiocytoma of bone. (15540465)
2004
35
Malignant fibrous histiocytoma at the site of a total hip arthroplasty. (15292811)
2004
36
Evaluation of immunohistochemical parameters as prognostic markers in malignant fibrous histiocytoma. (12883752)
2003
37
Inflammatory malignant fibrous histiocytoma of the gallbladder: report of a case. (11871825)
2002
38
Inclusion of malignant fibrous histiocytoma in the tumour spectrum associated with hereditary non-polyposis colorectal cancer. (11066081)
2000
39
IL-6 in a pleomorphic type of malignant fibrous histiocytoma presenting high fever. (9670836)
1998
40
P-53 positivity and high proliferative index: factors of bad prognosis in malignant fibrous histiocytomas. (8900926)
1995
41
Rothmund-Thomson syndrome and malignant fibrous histiocytoma: a case report. (7703036)
1995
42
Establishment and characterization of a human malignant fibrous histiocytoma cell line. (7586821)
1995
43
Phenotypic characterization of the human fibrous histiocytoma giant cell tumor (GCT) cell line and its cytokine repertoire. (7689482)
1993
44
A case of inflammatory malignant fibrous histiocytoma of the colon. (7690726)
1993
45
Prognostic factors of malignant fibrous histiocytoma of bone. A clinical and histopathologic analysis of 34 cases. (8364866)
1993
46
Malignant fibrous histiocytoma of bone. (2536999)
1989
47
Malignant fibrous histiocytoma of bone. (3006959)
1986
48
Palisading cutaneous fibrous histiocytoma. (3029199)
1986
49
Atypical, cutaneous fibrous histiocytoma with early metastasis. (3012378)
1986
50
Malignant fibrous histiocytoma of bone: an ultrastructural study. (16830447)
1981

Genetic Variations for Fibrous Histiocytoma

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Expression for genes affiliated with Fibrous Histiocytoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Fibrous Histiocytoma

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Pathways for genes affiliated with Fibrous Histiocytoma

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37NCBI BioSystems Database
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Pathways related to Fibrous Histiocytoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.5LYZ, CD34, MYOD1

Compounds for genes affiliated with Fibrous Histiocytoma

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44Novoseek, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB, 2BitterDB
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Compounds related to Fibrous Histiocytoma according to GeneCards/GeneDecks:

(show all 48)
idCompoundScoreTop Affiliating Genes
1progesterone44 59 28 11 2415.1F13A1, ATF1, MDM2, S100A1, VIM, DES
2paraffin4411.1SERPINA3, VIM, S100A1, MDM2, F13A1, DES
3calcium44 49 11 2414.1HSPB2, S100A1, MDM2, ATF1, F13A1, DES
4oligonucleotide4411.1VIM, HSPB2, MDM2, ATF1, F13A1, MYOD1
5vegf4411.1F13A1, MDM2, HSPB2, VIM, DES, MYOD1
612-o-tetradecanoylphorbol 13-acetate4411.1VIM, HSPB2, ATF1, DES, MYOD1, MYOG
7steroid4411.1MDM2, ATF1, DES, MYOD1, MYOG, IL6R
8arginine4411.0VIM, HSPB2, MDM2, DES, MYOD1, IL6R
9retinoic acid44 2412.0VIM, S100A1, DES, MYOD1, MYOG, CD34
10iron44 2412.0VIM, HSPB2, S100A1, MDM2, F13A1, DES
11acetylcholine44 49 28 11 2415.0VIM, HSPB2, S100A1, DES, MYOD1, MYOG
12testosterone44 59 11 2414.0VIM, MDM2, DES, MYOD1, MYOG, IL6R
13hematoxylin4411.0VIM, S100A1, F13A1, DES, CD34
14cysteine4411.0VIM, S100A1, MDM2, DES, MYOD1, MYOG
15silver4411.0S100A1, F13A1, DES, CD34, SERPINA3
16reticulin4411.0VIM, F13A1, DES, CD34
17estrogen4411.0F13A1, MYOD1, MYOG
18b 7234411.0VIM, S100A1, F13A1, DES
19lysine4410.9VIM, HSPB2, MDM2, F13A1, DES, MYOD1
20tyrosine4410.9HSPB2, S100A1, MDM2, DES, MYOD1, MYOG
21creatinine4410.9HSPB2, MYOD1, IL6R, SERPINA3
22nacl4410.9HSPB2, S100A1, DES, SERPINA3, LYZ
23s 1004410.9DES, F13A1, VIM
24serine4410.9HSPB2, ATF1, DES, MYOD1, MYOG, SERPINA3
25glycogen44 2411.9FOXO4, MDM2, IL6R
26oxygen44 2411.9HSPB2, MDM2, DES, MYOD1, MYOG, MMP11
27heparin44 28 11 2413.9F13A1, DES, B3GAT1, SERPINA3
28toluidine4410.9DES, S100A1, VIM
29mucicarmine4410.9VIM, S100A1, DES
30estradiol44 11 2412.9VIM, MDM2, DES, IL6R, SERPINA3
31bromodeoxyuridine4410.9VIM, DES, MYOD1, MYOG
32zinc44 2411.9S100A1, MDM2, MYOD1, IL6R, MMP11, SERPINA3
33glucose4410.8SERPINA3, IL6R, MYOG
34methotrexate44 49 1112.8SERPINA3, IL6R, MDM2, VIM
35cyclic amp44 2411.8VIM, MDM2, ATF1, DES, MYOD1
36rubin4410.8SERPINA3, B3GAT1
37polyacrylamide4410.8SERPINA3, DES, F13A1, HSPB2
38orcein4410.8VIM, DES
39gefitinib44 49 1112.7EREG, MDM2, VIM
40procollagen4410.7F13A1
41fibrinogen4410.7SERPINA3, IL6R, DES, F13A1
42butyrate4410.7MYOD1, MYOG
432-methoxyethanol4410.6S100A1, VIM
44azathioprine44 49 2 1113.6VIM, DES, MYOD1
45wortmannin4410.6IL6R, MDM2, FOXO4, VIM
46biotin44 11 2412.5DES, S100A1, VIM
47pd 98,0594410.4HSPB2, MDM2, ATF1, MYOG
48vincristine44 49 1112.2MDM2, HSPB2, VIM

GO Terms for genes affiliated with Fibrous Histiocytoma

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16Gene Ontology
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Biological processes related to Fibrous Histiocytoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of smooth muscle cell differentiationGO:05115110.6EREG, FOXO4
2muscle cell fate commitmentGO:04269310.5MYOG, MYOD1
3cellular response to estradiol stimulusGO:07139210.5MYOG, MYOD1
4neurotrophin TRK receptor signaling pathwayGO:04801110.4FOXO4, MDM2, ATF1, EREG
5skeletal muscle fiber developmentGO:04874110.2MYOG, MYOD1

Molecular functions related to Fibrous Histiocytoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1identical protein bindingGO:04280210.6LYZ, DES, MDM2, S100A1, VIM

Products for genes affiliated with Fibrous Histiocytoma

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Sources for Fibrous Histiocytoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet