MCID: FBR003
MIFTS: 55

Fibrous Histiocytoma malady

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Summaries for Fibrous Histiocytoma

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Wikipedia:65 Benign fibrous histiocytomas (also known as Dermal dendrocytoma,Dermatofibroma,Fibrous... more...

MalaCards based summary: Fibrous Histiocytoma, also known as cutaneous fibrous histiocytoma, is related to cutaneous fibrous histiocytoma and dermatofibrosarcoma protuberans. An important gene associated with Fibrous Histiocytoma is ATF1 (activating transcription factor 1), and among its related pathways are Aurora B signaling and ERK Signaling. The compounds orcein and eosin have been mentioned in the context of this disorder. Affiliated tissues include bone, skin and breast, and related mouse phenotypes are tumorigenesis and normal.

Aliases & Classifications for Fibrous Histiocytoma

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Sources:
62UMLS, 8Disease Ontology, 10DISEASES, 44Novoseek, 57SNOMED-CT, 39NCIt, 34MeSH
See all sources

Fibrous Histiocytoma, Aliases & Descriptions:

Name: Fibrous Histiocytoma 8 10
Cutaneous Fibrous Histiocytoma 62
Histiocytoma, Benign Fibrous 62
Benign Fibrous Histiocytoma 8
 
Fibrous Histiocytoma Nos 8
Histiocytoma Fibrous 44
Fibroxanthoma Nos 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


External Ids:

Disease Ontology8 DOID:4415
NCIt39 C3739
MeSH34 D018219

Related Diseases for Fibrous Histiocytoma

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Diseases related to Fibrous Histiocytoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 207)
idRelated DiseaseScoreTop Affiliating Genes
1cutaneous fibrous histiocytoma31.7DES, F13A1
2dermatofibrosarcoma protuberans31.5MDM2
3dedifferentiated liposarcoma31.3DES, MDM2
4liposarcoma31.2MDM2, DES, VIM
5histiocytosis31.0CD68, HAVCR1
6hemangioma31.0CD68, F13A1
7myxoid liposarcoma31.0ATF1
8malignant histiocytosis30.9SERPINA3
9fibrosarcoma30.9VIM, DES, MDM2
10osteosarcoma30.8MYOD1, MDM2, IL6R
11epithelioid sarcoma30.7VIM, MUC1
12langerhans-cell histiocytosis30.7F13A1, CD68
13cystadenocarcinoma30.6MUC1
14meningioma30.6MUC1, CD68, VIM
15fibromatosis30.5DES, VIM
16sarcoma30.4DES, ATF1, VIM, MYOD1, MUC1, MDM2
17hodgkin's lymphoma30.4MDM2, CD68, IL6R
18spindle cell sarcoma30.3DES, MUC1, VIM
19chordoma30.3MUC1, VIM, DES
20non-hodgkin lymphoma30.3IL6R, MYOD1, MDM2
21leiomyosarcoma30.2DES, VIM, MUC1, MDM2, MYOD1
22rhabdomyosarcoma30.1VIM, DES, MYOD1, MDM2
23angiosarcoma30.1VIM, SERPINA3, MUC1
24rhabdoid tumor30.1VIM, MYOD1, DES, MUC1
25hemangiopericytoma29.8MUC1, MDM2, F13A1, DES, VIM
26adenocarcinoma29.6MDM2, VIM, F13A1, SERPINA3, MUC1
27giant cell tumor29.5SERPINA3, VIM, DES, MUC1, F13A1
28melanoma29.4F13A1, MYOD1, MDM2, CD68, ATF1, DES
29malignant fibroxanthoma29.2VIM, F13A1, SERPINA3, DES, MYOD1, MUC1
30histiocytoma11.6
31malignant fibrous histiocytoma of bone11.1
32pleomorphic malignant fibrous histiocytoma10.8
33diaphyseal medullary stenosis with malignant fibrous histiocytoma10.8
34aneurysm10.7
35hepatitis10.6
36alveolar soft part sarcoma10.5MYOD1
37infantile myofibromatosis10.5DES
38burn scar10.5
39burns10.5
40leukemoid reaction10.5
41thyroiditis10.5
42soft tissue sarcoma10.5
43adenomatoid tumor10.5VIM
44giant cell glioblastoma10.4MDM2
45malignant skin fibrous histiocytoma10.4
46sclerosing hemangioma10.4
47myxofibrosarcoma10.4
48hepatocellular carcinoma10.4
49leukemia10.4
50benign deep fibrous histiocytoma10.4

Graphical network of the top 20 diseases related to Fibrous Histiocytoma:



Diseases related to fibrous histiocytoma

Symptoms for Fibrous Histiocytoma

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Drugs & Therapeutics for Fibrous Histiocytoma

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Drug clinical trials:

Search ClinicalTrials for Fibrous Histiocytoma

Search NIH Clinical Center for Fibrous Histiocytoma

Genetic Tests for Fibrous Histiocytoma

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Anatomical Context for Fibrous Histiocytoma

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MalaCards organs/tissues related to Fibrous Histiocytoma:

32
Bone, Skin, Breast, Lung, Heart, Liver, Spleen, Colon, Pancreas, Kidney, Thyroid, Ovary, Cervix, T cells, Tongue, Trachea, Lymph node, Thymus, Brain, Smooth muscle, Adrenal gland, Prostate, Bone marrow, Skeletal muscle, Uterus, Testis, Testes, Monocytes, Endothelial

Animal Models for Fibrous Histiocytoma or affiliated genes

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MGI Mouse Phenotypes related to Fibrous Histiocytoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.8MDM2, IL6R, MUC1, MYOD1
2MP:00028738.3ATF1, MYOD1, MUC1, IL6R, MDM2
3MP:00107688.1DES, ATF1, F13A1, VIM, MYOD1, IL6R
4MP:00053977.9CD68, MDM2, IL6R, VIM, F13A1, HAVCR1
5MP:00053877.7HAVCR1, ATF1, VIM, IL6R, MDM2, CD68

Publications for Fibrous Histiocytoma

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Articles related to Fibrous Histiocytoma:

(show top 50)    (show all 737)
idTitleAuthorsYear
1
Epidermal inclusion cyst embedded in a recurrent benign fibrous histiocytoma. (25284857)
2014
2
Primary hepatic malignant fibrous histiocytoma mimicking hepatocellular carcinoma: A report of two cases. (25295102)
2014
3
Refractory Malignant Fibrous Histiocytoma: CT-guided Treatment with a Multidisciplinary, Minimally Invasive Approach. (24325132)
2013
4
An adolescent presenting with malignant fibrous histiocytoma of the testis: a case report. (23347569)
2013
5
Primary malignant fibrous histiocytoma of the renal pelvis: a 78-month follow-up case report. (24368887)
2013
6
A therapeutic strategy for metastatic malignant fibrous histiocytoma through mesenchymal stromal cell-mediated TRAIL production. (23108118)
2013
7
Cholesterotic Fibrous Histiocytoma. (23518637)
2013
8
Malignant fibrous histiocytoma of the breast in young male patient: a case report and a review of the literature. (23573437)
2013
9
Mediastinal epithelioid hemangioendothelioma with abundant spindle cells and osteoclast-like giant cells mimicking malignant fibrous histiocytoma. (23800015)
2013
10
Malignant fibrous histiocytoma at the site of an alumina-on-alumina-bearing total hip arthroplasty mimicking infected trochanteric bursitis. (21435828)
2012
11
Clinical and pathologic characteristics and surgical management of benign fibrous histiocytoma of the mandible: a case report. (22580097)
2012
12
Benign fibrous histiocytoma of vulva: rare case. (24293888)
2012
13
A p53 gene mutation in malignant fibrous histiocytoma associated with bone infarction. (22041521)
2011
14
Malignant fibrous histiocytoma two years after autologous stem cell transplant for Hodgkin lymphoma: evidence for genomic instability. (21488163)
2011
15
Primary hepatic malignant fibrous histiocytoma: diagnostic pitfalls and therapeutic challenge. (21830410)
2011
16
Benign fibrous histiocytoma of bone in a paediatric population: a report of 6 cases. (21409501)
2011
17
Phase II study of sunitinib malate, a multitargeted tyrosine kinase inhibitor in patients with relapsed or refractory soft tissue sarcomas. Focus on three prevalent histologies: leiomyosarcoma, liposarcoma and malignant fibrous histiocytoma. (21154746)
2011
18
Malignant fibrous histiocytoma of the small bowel with colon metastasis. (21590606)
2011
19
Pleomorphic malignant fibrous histiocytoma/undifferentiated high-grade pleomorphic sarcoma of the scrotum in a patient presenting as fournier gangrene: a case report. (20505510)
2010
20
An angiomatoid fibrous histiocytoma over the left pre auricular region in a 13-year-old boy. (20492821)
2010
21
A rare clinical presentation of a malignant fibrous histiocytoma within the iliopsoas muscle. (20056053)
2010
22
Cardiac metastasis in malignant fibrous histiocytoma. (18626538)
2008
23
Prognostic significance of ezrin expression in pleomorphic malignant fibrous histiocytoma. (17465259)
2007
24
Squamous epithelial-lined cyst occurring in an aneurysmal fibrous histiocytoma. (17519635)
2007
25
Benign fibrous histiocytoma associated with a frontoethmoidal mucopyocele and orbital abscess. (17519668)
2007
26
Malignant fibrous histiocytoma of the parotid gland. (18188922)
2007
27
Fibrous Histiocytoma-like Spindle-Cell Proliferation in the Nipple After Body-Piercing. (16501844)
2006
28
Angiomatoid variant of fibrous histiocytoma: a case report and review of literature. (16879335)
2006
29
Diaphyseal medullary stenosis with pleomorphic malignant fibrous histiocytoma of the bone: 99mTc hydroxymethylenediphosphonate and 201Tl chloride scintigraphy findings. (16715956)
2006
30
Aneurysmal fibrous histiocytoma of the skin: a rare variant of dermatofibroma. (16327640)
2005
31
Primary malignant fibrous histiocytoma of the pancreas: a case with K-ras mutation and a review of the literature. (16416164)
2005
32
Primary malignant fibrous histiocytoma of the jejunum metastatic to the spine: report of a case. (15879629)
2005
33
Malignant fibrous histiocytoma arising from the renal capsule. (16327309)
2005
34
Malignant fibrous histiocytoma, malignant melanoma and squamous cell carcinoma arising from different areas in an adult. (16440931)
2005
35
Expression of matrix metalloproteinase-9 correlates with poor prognosis in human malignant fibrous histiocytoma. (20368833)
2004
36
Expression profiling using tissue microarray in 211 malignant fibrous histiocytomas confirms the prognostic value of Ki-67. (15309631)
2004
37
Evaluation of immunohistochemical parameters as prognostic markers in malignant fibrous histiocytoma. (12883752)
2003
38
Clinicopathologic features, diagnosis, and treatment of malignant fibrous histiocytoma of bone. (10642003)
2000
39
Genetic characterization of angiomatoid fibrous histiocytoma identifies fusion of the FUS and ATF-1 genes induced by a chromosomal translocation involving bands 12q13 and 16p11. (11063792)
2000
40
Dedifferentiated liposarcoma with an inflammatory malignant fibrous histiocytoma-like component presenting a leukemoid reaction. (9311018)
1997
41
Cutaneous fibrous histiocytoma with osteoclast-like giant cells. (8863988)
1996
42
P-53 positivity and high proliferative index: factors of bad prognosis in malignant fibrous histiocytomas. (8900926)
1995
43
Palisading cutaneous fibrous histiocytoma. An immunohistochemical study demonstrating differentiation from dermal dendrocytes. (8311187)
1993
44
Phenotypic characterization of the human fibrous histiocytoma giant cell tumor (GCT) cell line and its cytokine repertoire. (7689482)
1993
45
p53 immunohistochemistry in malignant fibrous histiocytomas and other mesenchymal tumours. (1333524)
1992
46
Malignant fibrous histiocytomas in dogs and cats: an immunohistochemical study. (1332152)
1992
47
Chemotherapy-induced complete remission of a malignant fibrous histiocytoma of bone. An 11-year follow-up. (3008679)
1986
48
Postradiation malignant fibrous histiocytoma of bone. A clinicopathologic study of 20 patients. (3006524)
1986
49
A study on the osseous elements in malignant fibrous histiocytoma of bone. (2989393)
1985
50
Malignant fibrous histiocytoma of bone. (6262217)
1980

Variations for Fibrous Histiocytoma

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Expression for genes affiliated with Fibrous Histiocytoma

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Expression patterns in normal tissues for genes affiliated with Fibrous Histiocytoma

Search GEO for disease gene expression data for Fibrous Histiocytoma.

Pathways for genes affiliated with Fibrous Histiocytoma

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Pathways related to Fibrous Histiocytoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Signaling by Aurora kinases37
Aurora C signaling37
9.8VIM, DES
2
Show member pathways
8.4MDM2, IL6R, MUC1, VIM, ATF1, DES

Compounds for genes affiliated with Fibrous Histiocytoma

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Compounds related to Fibrous Histiocytoma according to GeneCards/GeneDecks:

(show top 50)    (show all 65)
idCompoundScoreTop Affiliating Genes
1orcein4410.1DES, VIM
2eosin449.9MUC1, VIM
3procollagen449.8DES, F13A1, VIM
4silver449.8SERPINA3, F13A1, DES
5mucicarmine449.8MUC1, VIM, DES
6progestin449.6DES, VIM, MUC1
7biotin44 24 1111.6MUC1, VIM, DES
8azathioprine44 2 50 1112.6MYOD1, VIM, DES
9toluidine449.5VIM, DES
10s 100449.5DES, F13A1, VIM, MUC1
11reticulin449.5MUC1, VIM, F13A1, DES
12b 723449.5DES, F13A1, VIM, MUC1
13hematoxylin449.5DES, F13A1, VIM, MUC1
14gold449.5MUC1, SERPINA3, DES
15fibrinogen449.5DES, F13A1, SERPINA3, IL6R
16adriamycin449.4DES, VIM, MUC1, MDM2
17hyaluronic acid44 2410.4MUC1, VIM, DES
18bromodeoxyuridine449.3DES, VIM, MYOD1
19dihydrotestosterone44 28 24 1112.3MUC1, VIM, DES
20thymidine44 2410.2DES, MUC1, IL6R, MDM2
21acetylcholine44 50 28 24 1113.2MYOD1, VIM, SERPINA3, DES
22heparin44 28 24 1112.2VIM, SERPINA3, F13A1, DES
23iron44 2410.2MDM2, VIM, SERPINA3, F13A1, DES
24butyrate449.1VIM, MYOD1, MUC1, IL6R
25glycogen44 2410.1DES, VIM, MUC1, IL6R, MDM2
26lysine449.1DES, F13A1, VIM, MYOD1, MDM2
27leucine449.0ATF1, SERPINA3, VIM, MYOD1
28methotrexate50 44 1111.0SERPINA3, VIM, MUC1, IL6R, MDM2
29actinomycin d448.9DES, VIM, MYOD1, MUC1, MDM2
30dexamethasone44 50 28 1111.9MDM2, IL6R, MUC1, VIM, SERPINA3
31threonine448.8MDM2, MUC1, MYOD1, SERPINA3, DES
32steroid448.7DES, ATF1, SERPINA3, MYOD1, IL6R, MDM2
33oxygen44 249.7DES, SERPINA3, MYOD1, MUC1, MDM2
34estradiol44 24 1110.7DES, SERPINA3, VIM, MUC1, IL6R, MDM2
35cyclic amp44 249.7DES, ATF1, VIM, MYOD1, MUC1, MDM2
3612-o-tetradecanoylphorbol 13-acetate448.7DES, ATF1, VIM, MYOD1, MUC1, IL6R
37arginine448.6DES, SERPINA3, VIM, MYOD1, IL6R, MDM2
38testosterone44 61 24 1111.6DES, VIM, MYOD1, MUC1, IL6R, MDM2
39glucose448.5DES, ATF1, SERPINA3, MYOD1, MUC1, IL6R
40creatinine448.5DES, SERPINA3, VIM, MYOD1, MUC1, IL6R
41cysteine448.5DES, SERPINA3, VIM, MYOD1, MUC1, MDM2
42retinoic acid44 249.5DES, SERPINA3, VIM, MYOD1, MUC1, IL6R
43oligonucleotide448.4ATF1, F13A1, SERPINA3, VIM, MYOD1, IL6R
44vegf448.3DES, F13A1, VIM, MYOD1, MUC1, IL6R
45tyrosine448.2HAVCR1, DES, MYOD1, MUC1, IL6R, MDM2
46estrogen448.2DES, F13A1, SERPINA3, VIM, MYOD1, MUC1
47serine448.2DES, ATF1, SERPINA3, VIM, MYOD1, MUC1
48progesterone44 28 61 24 1112.2DES, ATF1, F13A1, SERPINA3, VIM, MUC1
49calcium44 50 24 1111.0DES, ATF1, F13A1, SERPINA3, MYOD1, MUC1
50paraffin447.4CD68, DES, F13A1, SERPINA3, VIM, MYOD1

GO Terms for genes affiliated with Fibrous Histiocytoma

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Biological processes related to Fibrous Histiocytoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1muscle filament slidingGO:0300499.8VIM, DES
2acute-phase responseGO:0069539.4IL6R, SERPINA3

Molecular functions related to Fibrous Histiocytoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1scaffold protein bindingGO:0971109.8MDM2, VIM
2protein bindingGO:0055156.6MDM2, DES, ATF1, MFHAS1, SERPINA3, VIM

Products for genes affiliated with Fibrous Histiocytoma

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Sources for Fibrous Histiocytoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet