MCID: FBR003
MIFTS: 46

Fibrous Histiocytoma malady

Summaries for Fibrous Histiocytoma

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Wikipedia:63 Benign fibrous histiocytomas (also known as Dermal dendrocytoma,Dermatofibroma,Fibrous... more...

MalaCards based summary: Fibrous Histiocytoma, also known as histiocytoma, benign fibrous, is related to cutaneous fibrous histiocytoma and dermatofibrosarcoma protuberans. An important gene associated with Fibrous Histiocytoma is ATF1 (activating transcription factor 1), and among its related pathways are Aurora B signaling and ERK Signaling. The compounds orcein and eosin have been mentioned in the context of this disorder. Affiliated tissues include bone, skin and breast, and related mouse phenotypes are tumorigenesis and normal.

Aliases & Classifications for Fibrous Histiocytoma

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Sources:
9Disease Ontology, 11DISEASES, 43Novoseek, 60UMLS, 55SNOMED-CT, 33MeSH, 38NCIt
See all sources

Fibrous Histiocytoma, Aliases & Descriptions:

Name: Fibrous Histiocytoma 9 11
Histiocytoma, Benign Fibrous 60
Benign Fibrous Histiocytoma 9
 
Fibrous Histiocytoma Nos 9
Histiocytoma Fibrous 43
Fibroxanthoma Nos 9


External Ids:

Disease Ontology9 DOID:4415
MeSH33 D018219
NCIt38 C3739

Related Diseases for Fibrous Histiocytoma

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Diseases related to Fibrous Histiocytoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 207)
idRelated DiseaseScoreTop Affiliating Genes
1cutaneous fibrous histiocytoma31.7F13A1, DES
2dermatofibrosarcoma protuberans31.5MDM2
3dedifferentiated liposarcoma31.3DES, MDM2
4liposarcoma31.2DES, VIM, MDM2
5histiocytosis31.0CD68, HAVCR1
6hemangioma31.0CD68, F13A1
7myxoid liposarcoma31.0ATF1
8malignant histiocytosis30.9SERPINA3
9fibrosarcoma30.9MDM2, VIM, DES
10epithelioid sarcoma30.8VIM, MUC1
11langerhans-cell histiocytosis30.7F13A1, CD68
12kidney disease30.6CD68, HAVCR1
13cystadenocarcinoma30.6MUC1
14hodgkin lymphoma30.6IL6R, MDM2, CD68
15fibromatosis30.5DES, VIM
16giant cell tumor30.5VIM, IL6R
17hepatocellular carcinoma30.4MDM2, IL6R, F13A1, ATF1
18sarcoma30.4DES, ATF1, F13A1, VIM, MYOD1, MUC1
19spindle cell sarcoma30.3DES, VIM, MUC1
20chordoma30.3MUC1, VIM, DES
21leiomyosarcoma30.2DES, VIM, MYOD1, MUC1, MDM2
22rhabdomyosarcoma30.1DES, VIM, MYOD1, MDM2
23angiosarcoma30.1SERPINA3, VIM, MUC1
24rhabdoid tumor30.1DES, VIM, MYOD1, MUC1
25hemangiopericytoma29.8MDM2, MUC1, VIM, F13A1, DES
26adenocarcinoma29.6F13A1, SERPINA3, VIM, MUC1, MDM2
27melanoma29.4DES, ATF1, F13A1, SERPINA3, VIM, MYOD1
28malignant fibroxanthoma29.1CD68, DES, F13A1, SERPINA3, VIM, MYOD1
29histiocytoma11.6
30malignant fibrous histiocytoma of bone11.1
31diaphyseal medullary stenosis with malignant fibrous histiocytoma10.8
32pleomorphic malignant fibrous histiocytoma10.8
33aneurysm10.7
34hepatitis10.6
35undifferentiated pleomorphic sarcoma10.6
36peripheral primitive neuroectodermal tumor10.6ATF1
37alveolar soft-part sarcoma10.5MYOD1
38infantile myofibromatosis10.5DES
39burn scar10.5
40burns10.5
41malignant skin fibrous histiocytoma10.5
42leukemoid reaction10.5
43thyroiditis10.5
44adenomatoid tumor10.4VIM
45giant cell glioblastoma10.4MDM2
46benign deep fibrous histiocytoma10.4
47sclerosing hemangioma10.4
48soft tissue sarcoma10.4
49retinoblastoma10.4
50leukemia10.4

Graphical network of the top 20 diseases related to Fibrous Histiocytoma:



Diseases related to fibrous histiocytoma

Symptoms for Fibrous Histiocytoma

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Drugs & Therapeutics for Fibrous Histiocytoma

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Drug clinical trials:

Search ClinicalTrials for Fibrous Histiocytoma

Search NIH Clinical Center for Fibrous Histiocytoma

Genetic Tests for Fibrous Histiocytoma

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Anatomical Context for Fibrous Histiocytoma

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MalaCards organs/tissues related to Fibrous Histiocytoma:

31
Bone, Skin, Breast, Lung, Heart, Liver, Spleen, Colon, Kidney, Pancreas, Thyroid, Ovary, Cervix, T cells, Tongue, Trachea, Lymph node, Thymus, Brain, Smooth muscle, Adrenal gland, Prostate, Testes, Bone marrow, Skeletal muscle, Uterus, Testis, Monocytes, Endothelial

Animal Models for Fibrous Histiocytoma or affiliated genes

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MGI Mouse Phenotypes related to Fibrous Histiocytoma:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.8MDM2, IL6R, MUC1, MYOD1
2MP:00028738.3ATF1, MYOD1, MUC1, IL6R, MDM2
3MP:00107688.1DES, ATF1, F13A1, VIM, MYOD1, IL6R
4MP:00053977.9CD68, MDM2, IL6R, VIM, F13A1, HAVCR1
5MP:00053877.7HAVCR1, ATF1, VIM, IL6R, MDM2, CD68

Publications for Fibrous Histiocytoma

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Articles related to Fibrous Histiocytoma:

(show top 50)    (show all 750)
idTitleAuthorsYear
1
Primary pulmonary malignant fibrous histiocytoma. (25838959)
2015
2
Malignant fibrous histiocytoma: an uncommon sarcoma with pathological fracture of mandible. (25838711)
2015
3
Epidermal inclusion cyst embedded in a recurrent benign fibrous histiocytoma. (25284857)
2014
4
Primary hepatic malignant fibrous histiocytoma mimicking hepatocellular carcinoma: A report of two cases. (25295102)
2014
5
Refractory Malignant Fibrous Histiocytoma: CT-guided Treatment with a Multidisciplinary, Minimally Invasive Approach. (24325132)
2013
6
An adolescent presenting with malignant fibrous histiocytoma of the testis: a case report. (23347569)
2013
7
Primary malignant fibrous histiocytoma of the renal pelvis: a 78-month follow-up case report. (24368887)
2013
8
A therapeutic strategy for metastatic malignant fibrous histiocytoma through mesenchymal stromal cell-mediated TRAIL production. (23108118)
2013
9
Cholesterotic Fibrous Histiocytoma. (23518637)
2013
10
Malignant fibrous histiocytoma of the breast in young male patient: a case report and a review of the literature. (23573437)
2013
11
Mediastinal epithelioid hemangioendothelioma with abundant spindle cells and osteoclast-like giant cells mimicking malignant fibrous histiocytoma. (23800015)
2013
12
Malignant fibrous histiocytoma at the site of an alumina-on-alumina-bearing total hip arthroplasty mimicking infected trochanteric bursitis. (21435828)
2012
13
Clinical and pathologic characteristics and surgical management of benign fibrous histiocytoma of the mandible: a case report. (22580097)
2012
14
Benign fibrous histiocytoma of vulva: rare case. (24293888)
2012
15
A p53 gene mutation in malignant fibrous histiocytoma associated with bone infarction. (22041521)
2011
16
Malignant fibrous histiocytoma two years after autologous stem cell transplant for Hodgkin lymphoma: evidence for genomic instability. (21488163)
2011
17
Primary hepatic malignant fibrous histiocytoma: diagnostic pitfalls and therapeutic challenge. (21830410)
2011
18
Benign fibrous histiocytoma of bone in a paediatric population: a report of 6 cases. (21409501)
2011
19
Phase II study of sunitinib malate, a multitargeted tyrosine kinase inhibitor in patients with relapsed or refractory soft tissue sarcomas. Focus on three prevalent histologies: leiomyosarcoma, liposarcoma and malignant fibrous histiocytoma. (21154746)
2011
20
Malignant fibrous histiocytoma of the small bowel with colon metastasis. (21590606)
2011
21
Pleomorphic malignant fibrous histiocytoma/undifferentiated high-grade pleomorphic sarcoma of the scrotum in a patient presenting as fournier gangrene: a case report. (20505510)
2010
22
An angiomatoid fibrous histiocytoma over the left pre auricular region in a 13-year-old boy. (20492821)
2010
23
Prognostic significance of ezrin expression in pleomorphic malignant fibrous histiocytoma. (17465259)
2007
24
Squamous epithelial-lined cyst occurring in an aneurysmal fibrous histiocytoma. (17519635)
2007
25
Benign fibrous histiocytoma associated with a frontoethmoidal mucopyocele and orbital abscess. (17519668)
2007
26
Malignant fibrous histiocytoma of the parotid gland. (18188922)
2007
27
Fibrous Histiocytoma-like Spindle-Cell Proliferation in the Nipple After Body-Piercing. (16501844)
2006
28
Angiomatoid variant of fibrous histiocytoma: a case report and review of literature. (16879335)
2006
29
Diaphyseal medullary stenosis with pleomorphic malignant fibrous histiocytoma of the bone: 99mTc hydroxymethylenediphosphonate and 201Tl chloride scintigraphy findings. (16715956)
2006
30
Aneurysmal fibrous histiocytoma of the skin: a rare variant of dermatofibroma. (16327640)
2005
31
Primary malignant fibrous histiocytoma of the pancreas: a case with K-ras mutation and a review of the literature. (16416164)
2005
32
Primary malignant fibrous histiocytoma of the jejunum metastatic to the spine: report of a case. (15879629)
2005
33
Malignant fibrous histiocytoma arising from the renal capsule. (16327309)
2005
34
Malignant fibrous histiocytoma, malignant melanoma and squamous cell carcinoma arising from different areas in an adult. (16440931)
2005
35
Expression of matrix metalloproteinase-9 correlates with poor prognosis in human malignant fibrous histiocytoma. (20368833)
2004
36
Expression profiling using tissue microarray in 211 malignant fibrous histiocytomas confirms the prognostic value of Ki-67. (15309631)
2004
37
Evaluation of immunohistochemical parameters as prognostic markers in malignant fibrous histiocytoma. (12883752)
2003
38
Clinicopathologic features, diagnosis, and treatment of malignant fibrous histiocytoma of bone. (10642003)
2000
39
Genetic characterization of angiomatoid fibrous histiocytoma identifies fusion of the FUS and ATF-1 genes induced by a chromosomal translocation involving bands 12q13 and 16p11. (11063792)
2000
40
Dedifferentiated liposarcoma with an inflammatory malignant fibrous histiocytoma-like component presenting a leukemoid reaction. (9311018)
1997
41
Cutaneous fibrous histiocytoma with osteoclast-like giant cells. (8863988)
1996
42
P-53 positivity and high proliferative index: factors of bad prognosis in malignant fibrous histiocytomas. (8900926)
1995
43
Palisading cutaneous fibrous histiocytoma. An immunohistochemical study demonstrating differentiation from dermal dendrocytes. (8311187)
1993
44
Phenotypic characterization of the human fibrous histiocytoma giant cell tumor (GCT) cell line and its cytokine repertoire. (7689482)
1993
45
p53 immunohistochemistry in malignant fibrous histiocytomas and other mesenchymal tumours. (1333524)
1992
46
Malignant fibrous histiocytomas in dogs and cats: an immunohistochemical study. (1332152)
1992
47
Chemotherapy-induced complete remission of a malignant fibrous histiocytoma of bone. An 11-year follow-up. (3008679)
1986
48
Postradiation malignant fibrous histiocytoma of bone. A clinicopathologic study of 20 patients. (3006524)
1986
49
A study on the osseous elements in malignant fibrous histiocytoma of bone. (2989393)
1985
50
Malignant fibrous histiocytoma of bone. (6262217)
1980

Variations for Fibrous Histiocytoma

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Expression for genes affiliated with Fibrous Histiocytoma

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Search GEO for disease gene expression data for Fibrous Histiocytoma.

Pathways for genes affiliated with Fibrous Histiocytoma

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Pathways related to Fibrous Histiocytoma according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Signaling by Aurora kinases36
Aurora C signaling36
9.8VIM, DES
2
Show member pathways
8.4MDM2, IL6R, MUC1, VIM, ATF1, DES

Compounds for genes affiliated with Fibrous Histiocytoma

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Compounds related to Fibrous Histiocytoma according to GeneCards Suite gene sharing:

(show top 50)    (show all 65)
idCompoundScoreTop Affiliating Genes
1orcein4310.1DES, VIM
2eosin439.9MUC1, VIM
3procollagen439.8VIM, F13A1, DES
4silver439.8F13A1, SERPINA3, DES
5mucicarmine439.8DES, VIM, MUC1
6progestin439.6VIM, MUC1, DES
7biotin43 24 1211.6DES, VIM, MUC1
8azathioprine43 2 49 1212.6MYOD1, DES, VIM
9toluidine439.5DES, VIM
10s 100439.5MUC1, VIM, DES, F13A1
11reticulin439.5DES, MUC1, VIM, F13A1
12b 723439.5MUC1, VIM, F13A1, DES
13hematoxylin439.5F13A1, VIM, DES, MUC1
14gold439.5DES, SERPINA3, MUC1
15fibrinogen439.5DES, IL6R, F13A1, SERPINA3
16adriamycin439.4DES, MUC1, VIM, MDM2
17hyaluronic acid43 2410.4VIM, DES, MUC1
18bromodeoxyuridine439.3MYOD1, VIM, DES
19dihydrotestosterone43 28 24 1212.3VIM, DES, MUC1
20thymidine43 2410.2MDM2, IL6R, DES, MUC1
21acetylcholine43 49 28 24 1213.2SERPINA3, MYOD1, DES, VIM
22heparin43 28 24 1212.2F13A1, SERPINA3, VIM, DES
23iron43 2410.2F13A1, DES, VIM, MDM2, SERPINA3
24butyrate439.1IL6R, VIM, MYOD1, MUC1
25glycogen43 2410.1MUC1, IL6R, MDM2, DES, VIM
26lysine439.1MDM2, VIM, DES, F13A1, MYOD1
27leucine439.0SERPINA3, VIM, MYOD1, ATF1
28methotrexate49 43 1211.0VIM, IL6R, SERPINA3, MUC1, MDM2
29actinomycin d438.9MUC1, VIM, MDM2, MYOD1, DES
30dexamethasone43 49 28 1211.9IL6R, MUC1, SERPINA3, MDM2, VIM
31threonine438.8MDM2, SERPINA3, MYOD1, DES, MUC1
32steroid438.7MYOD1, DES, ATF1, SERPINA3, IL6R, MDM2
33oxygen43 249.7SERPINA3, MYOD1, MUC1, MDM2, DES
34estradiol43 24 1210.7SERPINA3, MUC1, DES, VIM, MDM2, IL6R
35cyclic amp43 249.7ATF1, MYOD1, DES, MDM2, MUC1, VIM
3612-o-tetradecanoylphorbol 13-acetate438.7DES, MUC1, MYOD1, VIM, ATF1, IL6R
37arginine438.6MDM2, DES, IL6R, MYOD1, VIM, SERPINA3
38testosterone43 59 24 1211.6DES, VIM, MDM2, MYOD1, MUC1, IL6R
39glucose438.5ATF1, IL6R, DES, MUC1, MYOD1, SERPINA3
40creatinine438.5IL6R, MYOD1, VIM, SERPINA3, DES, MUC1
41cysteine438.5MDM2, VIM, SERPINA3, MYOD1, MUC1, DES
42retinoic acid43 249.5IL6R, MUC1, MYOD1, VIM, SERPINA3, DES
43oligonucleotide438.4MDM2, MYOD1, VIM, SERPINA3, F13A1, ATF1
44vegf438.3VIM, MYOD1, IL6R, MUC1, MDM2, F13A1
45tyrosine438.2HAVCR1, IL6R, MDM2, DES, MYOD1, MUC1
46estrogen438.2SERPINA3, MDM2, VIM, F13A1, MYOD1, MUC1
47serine438.2SERPINA3, MDM2, MYOD1, ATF1, DES, VIM
48progesterone43 28 59 24 1212.2ATF1, DES, IL6R, SERPINA3, F13A1, VIM
49calcium43 49 24 1211.0MDM2, IL6R, MUC1, SERPINA3, ATF1, DES
50paraffin437.4F13A1, MYOD1, DES, SERPINA3, VIM, MUC1

GO Terms for genes affiliated with Fibrous Histiocytoma

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Biological processes related to Fibrous Histiocytoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1muscle filament slidingGO:00300499.8VIM, DES
2acute-phase responseGO:00069539.4IL6R, SERPINA3

Molecular functions related to Fibrous Histiocytoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1scaffold protein bindingGO:00971109.8MDM2, VIM
2protein bindingGO:00055156.6MDM2, DES, ATF1, MFHAS1, SERPINA3, VIM

Products for genes affiliated with Fibrous Histiocytoma

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Sources for Fibrous Histiocytoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet