MCID: FBR001
MIFTS: 27

Fibrous Meningioma

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Fibrous Meningioma

MalaCards integrated aliases for Fibrous Meningioma:

Name: Fibrous Meningioma 12 52 14 69
Fibroblastic Meningioma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:7211
MeSH 42 D008579
NCIt 47 C4330
SNOMED-CT 64 511008
UMLS 69 C0334606

Summaries for Fibrous Meningioma

MalaCards based summary : Fibrous Meningioma, also known as fibroblastic meningioma, is related to 2q31.1 microdeletion syndrome and laryngeal neuroendocrine tumor. An important gene associated with Fibrous Meningioma is MUC1 (Mucin 1, Cell Surface Associated), and among its related pathways/superpathways are Cytoskeletal Signaling and Neural Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Ifosfamide and Mechlorethamine have been mentioned in the context of this disorder. Affiliated tissues include liver and b cells, and related phenotypes are Decreased cell migration and respiratory system

Related Diseases for Fibrous Meningioma

Diseases related to Fibrous Meningioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 118)
id Related Disease Score Top Affiliating Genes
1 2q31.1 microdeletion syndrome 10.5 MUC1 VIM
2 laryngeal neuroendocrine tumor 10.5 MUC1 VIM
3 mannose-binding lectin protein deficiency 10.5 MUC1 VIM
4 vulvar angiokeratoma 10.5 MUC1 VIM
5 pyoderma 10.5 MUC1 VIM
6 bladder colloid adenocarcinoma 10.5 MUC1 VIM
7 cellular ependymoma 10.5 MUC1 VIM
8 lymphangiosarcoma 10.5 MUC1 VIM
9 persian gulf syndrome 10.5 MUC1 VIM
10 diffuse meningeal melanocytosis 10.4 MUC1 VIM
11 fallopian tube germ cell cancer 10.4 MUC1 VIM
12 ovary papillary carcinoma 10.4 MUC1 VIM
13 childhood pleomorphic rhabdomyosarcoma 10.4 MUC1 VIM
14 pancreatic serous cystadenoma 10.4 MUC1 VIM
15 sebaceous adenoma 10.4 MUC1 VIM
16 subependymal glioma 10.4 MUC1 VIM
17 short-rib thoracic dysplasia 12 10.4 MUC1 VIM
18 ovarian mucinous adenocarcinoma 10.4 MUC1 VIM
19 extraskeletal mesenchymal chondrosarcoma 10.4 MUC1 VIM
20 spondyloepimetaphyseal dysplasia, isidor type 10.4 MUC1 VIM
21 pancreatic ductal carcinoma 10.4 MUC1 VIM
22 secondary syphilis 10.4 MUC1 VIM
23 mesenchymoma 10.4 MUC1 VIM
24 spastic ataxia 3 10.4 MUC1 VIM
25 aortic aneurysm 10.4 F13A1 VIM
26 cortical blindness 10.4 F13A1 VIM
27 kidney benign neoplasm 10.4 MUC1 VIM
28 hemangioma 10.4 F13A1 VIM
29 mitochondrial myopathy with lactic acidosis 10.3 MUC1 VIM
30 mediastinal osteogenic sarcoma 10.3 MUC1 VIM
31 esophagus leiomyoma 10.3 MUC1 VIM
32 gallbladder pleomorphic giant cell adenocarcinoma 10.3 MUC1 NF2
33 conventional malignant hemangiopericytoma 10.3 MUC1 VIM
34 linitis plastica 10.3 MUC1 VIM
35 cystitis 10.3 MUC1 VIM
36 cerebrum cancer 10.3 MUC1 VIM
37 basosquamous carcinoma 10.3 NF2 VIM
38 serous cystadenocarcinoma 10.2 MUC1 VIM
39 chikungunya 10.2 MUC1 VIM
40 tumor of exocrine pancreas 10.2 MUC1 NF2
41 small cell neuroendocrine carcinoma 10.2 F13A1 VIM
42 preretinal fibrosis 10.1 MUC1 VIM
43 logopenic progressive aphasia 10.1 MUC1 S100B
44 heiner syndrome 10.1 MUC1 S100B
45 malignant adenofibroma 10.1 F13A1 VIM
46 meningitis and encephalitis 10.1 MUC1 S100B
47 dedifferentiated liposarcoma 10.1 MUC1 S100B
48 simple cryoglobulinemia 10.1 MUC1 S100B
49 mucinous ovarian cystadenoma 10.1 MUC1 S100B
50 enteric pattern testicular yolk sac tumor 10.1 MUC1 S100B

Graphical network of the top 20 diseases related to Fibrous Meningioma:



Diseases related to Fibrous Meningioma

Symptoms & Phenotypes for Fibrous Meningioma

GenomeRNAi Phenotypes related to Fibrous Meningioma according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased cell migration GR00055-A-1 8.8 NF2 VIM MUC1

MGI Mouse Phenotypes related to Fibrous Meningioma:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 respiratory system MP:0005388 8.92 F13A1 NF2 VIM CTSH

Drugs & Therapeutics for Fibrous Meningioma

Drugs for Fibrous Meningioma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ifosfamide Approved Phase 2 3778-73-2 3690
2
Mechlorethamine Approved Phase 2 51-75-2 4033
3 Alkylating Agents Phase 2
4 Isophosphamide mustard Phase 2
5
Doxorubicin Approved, Investigational Phase 1 23214-92-8 31703
6
Doxil Approved June 1999 Phase 1 31703
7 Anti-Bacterial Agents Phase 1
8 Antibiotics, Antitubercular Phase 1
9 Liver Extracts Phase 1
10 Topoisomerase Inhibitors Phase 1

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 S9624 Ifosfamide in Treating Patients With Meningeal Tumors Terminated NCT00003292 Phase 2 ifosfamide
2 Liposomal Doxorubicin in Treating Children With Refractory Solid Tumors Completed NCT00019630 Phase 1 doxorubicin HCl liposome

Search NIH Clinical Center for Fibrous Meningioma

Genetic Tests for Fibrous Meningioma

Anatomical Context for Fibrous Meningioma

MalaCards organs/tissues related to Fibrous Meningioma:

39
Liver, B Cells

Publications for Fibrous Meningioma

Articles related to Fibrous Meningioma:

id Title Authors Year
1
Multiple meningiomas consisting of fibrous meningioma, transitional meningioma, and meningotheliomatous meningioma in one adult patient. ( 26425174 )
2015
2
Marginal zone B-cell lymphoma involving a longstanding fibrous meningioma: an initial manifestation of systemic disease. ( 23850496 )
2013
3
Unusual fibrous meningioma in a patient with sarcoidosis: central necrosis associated with multinucleated giant cells. ( 21176717 )
2011
4
Meningioangiomatosis associated with fibrous meningioma in a dog. ( 19525526 )
2009
5
Multiple meningiomas consisting of fibrous meningioma and anaplastic meningioma. ( 12948473 )
2003
6
Fibrous meningioma in a patient with von Hippel-Lindau disease: a genetic analysis. ( 11765821 )
2001
7
Clinicopathological features of solitary fibrous tumor of the meninges: An immunohistochemical reappraisal of cases previously diagnosed to be fibrous meningioma or hemangiopericytoma. ( 11107053 )
2000
8
Fibrous meningioma with tyrosine-rich crystals. ( 10582272 )
1999
9
The immunophenotypic spectrum of meningeal hemangiopericytoma: a comparison with fibrous meningioma and solitary fibrous tumor of meninges. ( 9351573 )
1997
10
Solitary fibrous tumor of the meninges: a lesion distinct from fibrous meningioma. A clinicopathologic and immunohistochemical study. ( 8712177 )
1996

Variations for Fibrous Meningioma

Expression for Fibrous Meningioma

Search GEO for disease gene expression data for Fibrous Meningioma.

Pathways for Fibrous Meningioma

Pathways related to Fibrous Meningioma according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.61 MUC1 NF2 VIM
2 11.06 S100B VIM
3 10.86 F13A1 MUC1 VIM

GO Terms for Fibrous Meningioma

Cellular components related to Fibrous Meningioma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 ruffle GO:0001726 8.62 NF2 S100B

Sources for Fibrous Meningioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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