MCID: FLM001
MIFTS: 30

Filamentary Keratitis

Categories: Eye diseases

Aliases & Classifications for Filamentary Keratitis

MalaCards integrated aliases for Filamentary Keratitis:

Name: Filamentary Keratitis 12 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:4664
ICD10 33 H16.12
ICD9CM 35 370.23
SNOMED-CT 64 51286002
UMLS 69 C0155077

Summaries for Filamentary Keratitis

MalaCards based summary : Filamentary Keratitis is related to papilloma and keratitis. An important gene associated with Filamentary Keratitis is MUC4 (Mucin 4, Cell Surface Associated), and among its related pathways/superpathways are CLEC7A (Dectin-1) signaling and O-linked glycosylation. The drugs Ambroxol and Expectorants have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and brain.

Related Diseases for Filamentary Keratitis

Diseases related to Filamentary Keratitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 79)
id Related Disease Score Top Affiliating Genes
1 papilloma 10.7 MUC1 MUC4
2 keratitis 10.7
3 advanced sleep phase syndrome 10.7 MUC1 MUC4
4 klatskin's tumor 10.6 MUC1 MUC4
5 pancreatic intraductal papillary-colloid carcinoma 10.6 KRT1 MUC1
6 ichthyosis vulgaris 10.6 FLG KRT1
7 boylan dew greco syndrome 10.5 FLG KRT10
8 vulvar angiokeratoma 10.5 KRT10 MUC1
9 andersen syndrome 10.5 KRT1 KRT10
10 marburg hemorrhagic fever 10.5 KRT1 KRT10
11 ichthyosis histrix, curth-macklin type 10.5 KRT1 KRT10
12 squamous cell carcinoma 10.5 KRT1 KRT10
13 idiopathic central precocious puberty 10.5 MUC4 MUC5AC
14 aids wasting syndrome 10.5 FLG KRT10
15 mitochondrial myopathy with lactic acidosis 10.5 KRT1 MUC1
16 bile duct mucoepidermoid carcinoma 10.5 MUC1 MUC5AC
17 bamforth-lazarus syndrome 10.5 KRT1 KRT10
18 idiopathic neonatal atrial flutter 10.5 KRT1 KRT10
19 osteopoikilosis and dacryocystitis 10.5 BEST1 MERTK
20 testicular trophoblastic tumor 10.5 MUC1 MUC5AC
21 chondrodysplasia punctata, x-linked recessive 10.5 FLG KRT10
22 proliferative type fibrocystic change of breast 10.4 MUC1 MUC5AC
23 struma ovarii 10.4 MUC1 MUC4
24 uterine corpus adenofibroma 10.4 MUC1 MUC5AC
25 acinar cell cystadenocarcinoma 10.4 MUC1 MUC5AC
26 epicardium cancer 10.4 KRT10 MUC1
27 encephalopathy, lethal, due to defective mitochondrial peroxisomal fission 1 10.4 MUC1 MUC5AC
28 cavernous sinus thrombosis 10.4 MUC1 MUC5AC
29 condrodisplasia punctata rizomélica 10.4 MUC1 MUC5AC
30 classic variant of chromophobe renal cell carcinoma 10.4 MUC1 MUC5AC
31 lung disease 10.4 IL17A MUC1
32 uterine corpus apoplectic leiomyoma 10.4 MUC1 MUC5AC
33 palmoplantar keratoderma, nonepidermolytic, focal 10.4 FLG KRT10
34 conventional malignant hemangiopericytoma 10.3 KRT1 MUC1
35 sohval soffer syndrome 10.3 MUC1 MUC5AC
36 malignant biphasic mesothelioma 10.3 KRT10 MUC1 MUC4
37 peritoneal serous adenocarcinoma 10.3 MUC1 MUC5AC
38 epidermolysis bullosa simplex, dowling-meara type 10.3 KRT1 KRT10
39 autosomal recessive leukoencephalopathy-ischemic stroke-retinitis pigmentosa syndrome 10.3 FLG MUC5AC
40 sebaceous adenocarcinoma 10.3 MUC1 MUC4
41 pancreatic somatostatinoma 10.3 MUC1 MUC4
42 ichthyosis, cyclic, with epidermolytic hyperkeratosis 10.2 FLG KRT1 KRT10
43 diastrophic dysplasia 10.2 ELANE FLG
44 retinitis pigmentosa 30 10.2 FLG KRT1 KRT10
45 bilateral retinoblastoma 10.2 FLG KRT1 KRT10
46 breast leiomyoma 10.2 FLG KRT1 KRT10
47 mucoepidermoid esophageal carcinoma 10.2 MUC1 MUC4 MUC5AC
48 bestiality 10.2 MUC1 MUC4 MUC5AC
49 acute dacryoadenitis 10.2 MUC1 MUC4 MUC5AC
50 liver disease 10.2 MUC1 MUC4 MUC5AC

Graphical network of the top 20 diseases related to Filamentary Keratitis:



Diseases related to Filamentary Keratitis

Symptoms & Phenotypes for Filamentary Keratitis

Drugs & Therapeutics for Filamentary Keratitis

Drugs for Filamentary Keratitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 18)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ambroxol Approved Phase 1, Phase 2 18683-91-5
2 Expectorants Phase 1, Phase 2
3 Respiratory System Agents Phase 1, Phase 2
4
Ephedrine Approved 299-42-3 9294
5
Guaifenesin Approved, Vet_approved 93-14-1 3516
6
Pseudoephedrine Approved 90-82-4 7028
7 Adrenergic Agents
8 Adrenergic Agonists
9 Adrenergic alpha-Agonists
10 Anti-Obesity Agents
11 Appetite Depressants
12 Autonomic Agents
13
Chlorpheniramine 113-92-8, 132-22-9 2725
14 Chlorpheniramine, phenylpropanolamine drug combination
15 Nasal Decongestants
16 Neurotransmitter Agents
17 Peripheral Nervous System Agents
18 Vasoconstrictor Agents

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Effects of Oral Mucolytics on Tear Film and Ocular Surface Completed NCT01713179 Phase 1, Phase 2 Ambroxol hydrochloride (Mucopect®, 60 mg, Boehringer Ingelheim)
2 Mucinex® for Treatment of Filamentary Keratitis Recruiting NCT02859246 Mucinex®

Search NIH Clinical Center for Filamentary Keratitis

Genetic Tests for Filamentary Keratitis

Anatomical Context for Filamentary Keratitis

MalaCards organs/tissues related to Filamentary Keratitis:

39
Eye, Testes, Brain

Publications for Filamentary Keratitis

Articles related to Filamentary Keratitis:

(show all 33)
id Title Authors Year
1
Investigation of the clinical features in filamentary keratitis in Hangzhou, east of China. ( 27583881 )
2016
2
Treatment of Refractory Filamentary Keratitis With Autologous Serum Tears. ( 26657665 )
2015
3
Botulinum toxin injection for the management of refractory filamentary keratitis. ( 22491914 )
2012
4
Human epidermal growth factor eyedrops for cetuximab-related filamentary keratitis. ( 21690478 )
2011
5
Effect of lacrimal plugs combined with deproteinized calf blood extract eye gel for filamentary keratitis. ( 23243481 )
2010
6
Question: Can you identify this condition? Filamentary keratitis. ( 20631280 )
2010
7
Investigation of the corneal filament in filamentary keratitis. ( 19443713 )
2009
8
A case report and review of filamentary keratitis. ( 15682560 )
2005
9
Filamentary keratitis occurring after strabismus surgery. ( 15088057 )
2004
10
Management of filamentary keratitis associated with aqueous-deficient dry eye. ( 12808401 )
2003
11
Filamentary keratitis improved by blepharoptosis surgery: two cases. ( 14641279 )
2003
12
The beneficial effect of diclofenac sodium in the treatment of filamentary keratitis. ( 11405858 )
2001
13
Diclofenac sodium, 0.1% (Voltaren Ophtha), versus sodium chloride, 5%, in the treatment of filamentary keratitis. ( 10746444 )
2000
14
Filamentary keratitis caused by corneal occlusion in large-angle strabismus. ( 1574277 )
1992
15
Filamentary keratitis--the clinical challenges. ( 1813523 )
1991
16
Filamentary keratitis associated with diphenhydramine hydrochloride (Benadryl). ( 3953733 )
1986
17
The histopathology of filamentary keratitis. ( 4026649 )
1985
18
Eledoisin--a successful therapeutic concept for filamentary keratitis. ( 3862278 )
1985
19
Filamentary keratitis following penetrating keratoplasty. ( 6752802 )
1982
20
Filamentary keratitis. ( 7105733 )
1982
21
Filamentary keratitis. ( 7072810 )
1982
22
Filamentary keratitis and stromal neovascularization associated with brain-stem injury. ( 6158854 )
1980
23
Study of filamentary keratitis by replica technique. ( 380383 )
1979
24
Contact lens induced filamentary keratitis. ( 1200123 )
1975
25
Filamentary keratitis. ( 1064224 )
1975
26
Treatment of filamentary keratitis with the soft contact lens. ( 4759857 )
1973
27
Filamentary keratitis following cataract extraction. ( 5085203 )
1972
28
A modified Schirmer tear test technique. Its uses in aiding the diagnosis of chronic keratoconjuncitivitis sicca (filamentary keratitis) in dogs. ( 5435003 )
1970
29
Hereditary hemorrhagic telangiectasis (Rendu-Osler-Weber disease) with filamentary keratitis. ( 5764691 )
1969
30
Parenchymatous origin of filamentary keratitis; new histopathologic concepts. ( 13339914 )
1956
31
An unusual case of filamentary keratitis. ( 13248308 )
1955
32
Filamentary Keratitis. ( 16693066 )
1935
33
Case of Filamentary Keratitis. ( 19982517 )
1922

Variations for Filamentary Keratitis

Expression for Filamentary Keratitis

Search GEO for disease gene expression data for Filamentary Keratitis.

Pathways for Filamentary Keratitis

GO Terms for Filamentary Keratitis

Cellular components related to Filamentary Keratitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.91 ELANE KRT1 KRT10 MUC1 MUC16 MUC4
2 extracellular region GO:0005576 9.8 ELANE IL17A KRT1 MUC1 MUC16 MUC4
3 intermediate filament GO:0005882 9.58 FLG KRT1 KRT10
4 vesicle GO:0031982 9.5 MUC1 MUC16 MUC4
5 cornified envelope GO:0001533 9.33 FLG KRT1 KRT10
6 extracellular space GO:0005615 9.28 ELANE IL17A KRT1 KRT10 MERTK MUC1
7 Golgi lumen GO:0005796 9.26 MUC1 MUC16 MUC4 MUC5AC

Biological processes related to Filamentary Keratitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cornification GO:0070268 9.5 FLG KRT1 KRT10
2 stimulatory C-type lectin receptor signaling pathway GO:0002223 9.46 MUC1 MUC16 MUC4 MUC5AC
3 peptide cross-linking GO:0018149 9.43 FLG KRT1 KRT10
4 defense response to fungus GO:0050832 9.4 ELANE IL17A
5 establishment of skin barrier GO:0061436 9.37 FLG KRT1
6 O-glycan processing GO:0016266 9.26 MUC1 MUC16 MUC4 MUC5AC
7 skin epidermis development GO:0098773 8.8 FLG KRT1 KRT10

Molecular functions related to Filamentary Keratitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 structural molecule activity GO:0005198 8.96 FLG KRT1
2 structural constituent of epidermis GO:0030280 8.8 FLG KRT1 KRT10

Sources for Filamentary Keratitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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