MCID: FLM001
MIFTS: 33

Filamentary Keratitis

Categories: Eye diseases

Aliases & Classifications for Filamentary Keratitis

MalaCards integrated aliases for Filamentary Keratitis:

Name: Filamentary Keratitis 12 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:4664
ICD10 32 H16.12
ICD9CM 34 370.23
SNOMED-CT 64 51286002
UMLS 69 C0155077

Summaries for Filamentary Keratitis

MalaCards based summary : Filamentary Keratitis is related to keratitis, hereditary and adenomyoma. An important gene associated with Filamentary Keratitis is MUC4 (Mucin 4, Cell Surface Associated), and among its related pathways/superpathways are Keratinization and CLEC7A (Dectin-1) signaling. The drugs Ambroxol and Expectorants have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and brain.

Related Diseases for Filamentary Keratitis

Diseases related to Filamentary Keratitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 82)
# Related Disease Score Top Affiliating Genes
1 keratitis, hereditary 10.8
2 adenomyoma 10.5 MUC1 MUC4
3 breast secretory carcinoma 10.4 MUC1 MUC4
4 eccrine porocarcinoma 10.4 KRT1 MUC1
5 biliary tract neoplasm 10.4 MUC1 MUC4
6 ichthyosis vulgaris 10.4 FLG KRT1
7 recessive dystrophic epidermolysis bullosa 10.4 FLG KRT1
8 nodular hidradenoma 10.3 KRT10 MUC1
9 erythroderma, ichthyosiform, congenital reticular 10.3 KRT1 KRT10
10 epidermolytic acanthoma 10.3 KRT1 KRT10
11 osteofibrous dysplasia 10.3 KRT1 MUC1
12 discoid lupus erythematosus 10.3 FLG KRT10
13 ichthyosis, cyclic, with epidermolytic hyperkeratosis 10.3 KRT1 KRT10
14 cap polyposis 10.3 MUC4 MUC5AC
15 acanthoma 10.3 KRT1 KRT10
16 cystadenoma 10.3 MUC1 MUC4
17 ichthyosis, x-linked 10.3 FLG KRT10
18 breast mucoepidermoid carcinoma 10.3 MUC1 MUC5AC
19 striate palmoplantar keratoderma 10.3 KRT1 KRT10
20 rhyns syndrome 10.3 BEST1 MERTK
21 bile duct cystadenocarcinoma 10.3 MUC1 MUC5AC
22 mucinous ovarian cystadenoma 10.3 MUC1 MUC5AC
23 biliary papillomatosis 10.3 MUC1 MUC5AC
24 epithelioid sarcoma 10.3 KRT1 MUC1
25 colloid carcinoma of the pancreas 10.3 MUC1 MUC5AC
26 complete androgen insensitivity syndrome 10.3 MUC1 MUC5AC
27 intraneural perineurioma 10.3 KRT10 MUC1
28 meconium ileus 10.3 MUC1 MUC5AC
29 gastric tubular adenocarcinoma 10.2 MUC1 MUC5AC
30 pancreatic mucinous cystadenoma 10.2 MUC1 MUC5AC
31 pachyonychia congenita 1 10.2 FLG KRT10
32 pseudomyxoma peritonei 10.2 MUC1 MUC5AC
33 rheumatoid lung disease 10.2 IL17A MUC1
34 adenosquamous carcinoma 10.2 MUC1 MUC4
35 epstein-barr virus-associated gastric carcinoma 10.2 FLG MUC5AC
36 white sponge nevus 1 10.2 KRT1 KRT10
37 keratoacanthoma 10.2 FLG KRT10
38 bile duct adenocarcinoma 10.2 MUC1 MUC5AC
39 small intestinal adenocarcinoma 10.2 MUC1 MUC5AC
40 mucinous tubular and spindle renal cell carcinoma 10.2 KRT10 MUC1 MUC4
41 palmoplantar keratosis 10.1 KRT1 KRT10
42 ichthyosis, congenital, autosomal recessive 1 10.1 FLG KRT10
43 strabismus 10.1
44 palmoplantar keratoderma, nonepidermolytic 10.1 FLG KRT1 KRT10
45 epidermolysis bullosa simplex 10.1 FLG KRT1 KRT10
46 epidermolytic hyperkeratosis 10.1 FLG KRT1 KRT10
47 epidermodysplasia verruciformis 10.1 FLG KRT1 KRT10
48 breast metaplastic carcinoma 10.1 KRT10 MUC5AC
49 bile duct mucoepidermoid carcinoma 10.1 MUC1 MUC4 MUC5AC
50 chronic ethmoiditis 10.1 MUC1 MUC4 MUC5AC

Graphical network of the top 20 diseases related to Filamentary Keratitis:



Diseases related to Filamentary Keratitis

Symptoms & Phenotypes for Filamentary Keratitis

Drugs & Therapeutics for Filamentary Keratitis

Drugs for Filamentary Keratitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 18)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ambroxol Approved, Investigational Phase 1, Phase 2 18683-91-5
2 Expectorants Phase 1, Phase 2
3 Respiratory System Agents Phase 1, Phase 2
4
Ephedrine Approved 299-42-3 9294
5
Guaifenesin Approved, Investigational, Vet_approved 93-14-1 3516
6
Pseudoephedrine Approved 90-82-4 7028
7 Adrenergic Agents
8 Adrenergic Agonists
9 Adrenergic alpha-Agonists
10 Anti-Obesity Agents
11 Appetite Depressants
12 Autonomic Agents
13
Chlorpheniramine 113-92-8, 132-22-9 2725
14 Chlorpheniramine, phenylpropanolamine drug combination
15 Nasal Decongestants
16 Neurotransmitter Agents
17 Peripheral Nervous System Agents
18 Vasoconstrictor Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Effects of Oral Mucolytics on Tear Film and Ocular Surface Completed NCT01713179 Phase 1, Phase 2 Ambroxol hydrochloride (Mucopect®, 60 mg, Boehringer Ingelheim)
2 Mucinex® for Treatment of Filamentary Keratitis Recruiting NCT02859246 Mucinex®

Search NIH Clinical Center for Filamentary Keratitis

Genetic Tests for Filamentary Keratitis

Anatomical Context for Filamentary Keratitis

MalaCards organs/tissues related to Filamentary Keratitis:

38
Eye, Testes, Brain

Publications for Filamentary Keratitis

Articles related to Filamentary Keratitis:

(show all 36)
# Title Authors Year
1
Treatment and Resolution of Filamentary Keratitis in a Patient with Stiff Person Syndrome. ( 29040122 )
2018
2
Ocular-muscle surgery for filamentary keratitis that developed in double elevator palsy. ( 29270032 )
2017
3
Filamentary Keratitis as Indication. ( 29034868 )
2017
4
Investigation of the clinical features in filamentary keratitis in Hangzhou, east of China. ( 27583881 )
2016
5
Treatment of Refractory Filamentary Keratitis With Autologous Serum Tears. ( 26657665 )
2015
6
Botulinum toxin injection for the management of refractory filamentary keratitis. ( 22491914 )
2012
7
Human epidermal growth factor eyedrops for cetuximab-related filamentary keratitis. ( 21690478 )
2011
8
Question: Can you identify this condition? Filamentary keratitis. ( 20631280 )
2010
9
Effect of lacrimal plugs combined with deproteinized calf blood extract eye gel for filamentary keratitis. ( 23243481 )
2010
10
Investigation of the corneal filament in filamentary keratitis. ( 19443713 )
2009
11
A case report and review of filamentary keratitis. ( 15682560 )
2005
12
Filamentary keratitis occurring after strabismus surgery. ( 15088057 )
2004
13
Management of filamentary keratitis associated with aqueous-deficient dry eye. ( 12808401 )
2003
14
Filamentary keratitis improved by blepharoptosis surgery: two cases. ( 14641279 )
2003
15
The beneficial effect of diclofenac sodium in the treatment of filamentary keratitis. ( 11405858 )
2001
16
Diclofenac sodium, 0.1% (Voltaren Ophtha), versus sodium chloride, 5%, in the treatment of filamentary keratitis. ( 10746444 )
2000
17
Filamentary keratitis caused by corneal occlusion in large-angle strabismus. ( 1574277 )
1992
18
Filamentary keratitis--the clinical challenges. ( 1813523 )
1991
19
Filamentary keratitis associated with diphenhydramine hydrochloride (Benadryl). ( 3953733 )
1986
20
Eledoisin--a successful therapeutic concept for filamentary keratitis. ( 3862278 )
1985
21
The histopathology of filamentary keratitis. ( 4026649 )
1985
22
Filamentary keratitis following penetrating keratoplasty. ( 6752802 )
1982
23
Filamentary keratitis. ( 7072810 )
1982
24
Filamentary keratitis. ( 7105733 )
1982
25
Filamentary keratitis and stromal neovascularization associated with brain-stem injury. ( 6158854 )
1980
26
Study of filamentary keratitis by replica technique. ( 380383 )
1979
27
Filamentary keratitis. ( 1064224 )
1975
28
Contact lens induced filamentary keratitis. ( 1200123 )
1975
29
Treatment of filamentary keratitis with the soft contact lens. ( 4759857 )
1973
30
Filamentary keratitis following cataract extraction. ( 5085203 )
1972
31
A modified Schirmer tear test technique. Its uses in aiding the diagnosis of chronic keratoconjuncitivitis sicca (filamentary keratitis) in dogs. ( 5435003 )
1970
32
Hereditary hemorrhagic telangiectasis (Rendu-Osler-Weber disease) with filamentary keratitis. ( 5764691 )
1969
33
Parenchymatous origin of filamentary keratitis; new histopathologic concepts. ( 13339914 )
1956
34
An unusual case of filamentary keratitis. ( 13248308 )
1955
35
Filamentary Keratitis. ( 16693066 )
1935
36
Case of Filamentary Keratitis. ( 19982517 )
1922

Variations for Filamentary Keratitis

Expression for Filamentary Keratitis

Search GEO for disease gene expression data for Filamentary Keratitis.

Pathways for Filamentary Keratitis

GO Terms for Filamentary Keratitis

Cellular components related to Filamentary Keratitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.91 ELANE KRT1 KRT10 MUC1 MUC16 MUC4
2 extracellular region GO:0005576 9.8 ELANE IL17A KRT1 MUC1 MUC16 MUC4
3 intermediate filament GO:0005882 9.58 FLG KRT1 KRT10
4 vesicle GO:0031982 9.5 MUC1 MUC16 MUC4
5 cornified envelope GO:0001533 9.33 FLG KRT1 KRT10
6 extracellular space GO:0005615 9.28 ELANE IL17A KRT1 KRT10 MERTK MUC1
7 Golgi lumen GO:0005796 9.26 MUC1 MUC16 MUC4 MUC5AC

Biological processes related to Filamentary Keratitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cornification GO:0070268 9.43 FLG KRT1 KRT10
2 defense response to fungus GO:0050832 9.37 ELANE IL17A
3 peptide cross-linking GO:0018149 9.33 FLG KRT1 KRT10
4 establishment of skin barrier GO:0061436 9.32 FLG KRT1
5 stimulatory C-type lectin receptor signaling pathway GO:0002223 9.26 MUC1 MUC16 MUC4 MUC5AC
6 O-glycan processing GO:0016266 8.92 MUC1 MUC16 MUC4 MUC5AC

Molecular functions related to Filamentary Keratitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural molecule activity GO:0005198 9.13 FLG KRT1 KRT10
2 structural constituent of epidermis GO:0030280 8.8 FLG KRT1 KRT10

Sources for Filamentary Keratitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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