MCID: FLR002
MIFTS: 60

Filariasis malady

Infectious diseases category

Summaries for Filariasis

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A parasitic helminthiasis infectious disease that involves parasitic infection of the lymphatics and subcutaneous tissue by nematodes of the superfamily filarioidea.

MalaCards: Filariasis, also known as disease due to superfamily filarioidea, is related to onchocerciasis and malaria. An important gene associated with Filariasis is CHIT1 (chitinase 1 (chitotriosidase)), and among its related pathways are Malaria and IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types. The compounds amphotericin b and cyclosporin a have been mentioned in the context of this disorder. Affiliated tissues include testes, breast and t cells, and related mouse phenotypes are no phenotypic analysis and immune system.

Wikipedia:63 Filariasis (or philariasis) is a parasitic disease that is caused by thread-like roundworms belonging to... more...

Aliases & Classifications for Filariasis

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8Disease Ontology, 10DISEASES, 44Novoseek, 48Orphanet, 60UMLS, 27ICD9CM, 56SNOMED-CT, 39NCIt, 34MeSH, 26ICD10 via Orphanet, 35MESH via Orphanet, 61UMLS via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases


Characteristics (Orphanet epidemiological data):

48
filariasis:
Inheritance: Sporadic; Age of onset: Variable


Aliases & Descriptions:

filariasis 8 10 44 48 60
disease due to superfamily filarioidea 8
filariasis, unspecified 8
unspecified filariasis 8
filariasis nos 8


External Ids:

Disease Ontology8 DOID:1080
ICD9CM27 125.9
NCIt39 C34611
MeSH34 D005368
ICD10 via Orphanet26 B72, B73, B74.0 B74.1, B74.2, B74.3, B74.4, B74.8, B74.9, more
MESH via Orphanet35 D005368
UMLS via Orphanet61 C0016085

Related Diseases for Filariasis

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Filariasis:



Diseases related to filariasis

Clinical Features for Filariasis

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Drugs & Therapeutics for Filariasis

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Filariasis

Drug clinical trials:

Search ClinicalTrials for Filariasis

Search NIH Clinical Center for Filariasis

Search CenterWatch for Filariasis

Genetic Tests for Filariasis

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Anatomical Context for Filariasis

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32MalaCards
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MalaCards organs/tissues related to Filariasis:

32
Testes, Breast, T cells, B cells, Kidney, Endothelial

Animal Models for Filariasis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Filariasis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000301210.2KIF22, IGHE, PRDX4
2MP:00053879.3IL5, TLR4, TLR2, TLR1, ICOS, TNFRSF18
3MP:00053979.3TLR4, TLR2, ICOS, TNFRSF18, IGHE, CD27

Publications for Filariasis

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50PubMed
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Articles related to Filariasis:

(show top 50)    (show all 580)
idTitleAuthorsYear
1
Correction: Sequential Modelling of the Effects of Mass Drug Treatments on Anopheline-Mediated Lymphatic Filariasis Infection in Papua New Guinea. (24404095)
2014
2
Global programme to eliminate lymphatic filariasis: progress report for 2012. (24073461)
2013
3
Inter and intra-specific diversity of parasites that cause lymphatic filariasis. (23201850)
2013
4
Toward the elimination of lymphatic filariasis by 2020: treatment update and impact assessment for the endgame. (23879610)
2013
5
A review of factors that influence individual compliance with mass drug administration for elimination of lymphatic filariasis. (24278486)
2013
6
Lymphatic filariasis in Papua New Guinea: distribution at district level and impact of mass drug administration, 1980 to 2011. (23311302)
2013
7
Knowledge and practice related to compliance with mass drug administration during the Egyptian national filariasis elimination program. (23751402)
2013
8
Filariasis and pleural effusion. (24339510)
2013
9
The role of personal opinions and experiences in compliance with mass drug administration for lymphatic filariasis elimination in Kenya. (23185256)
2012
10
Data base management system for lymphatic filariasis--a neglected tropical disease. (22792200)
2012
11
Lymphangiosarcoma arising after 33 years within a background of chronic filariasis: a case report with review of literature. (22211335)
2012
12
The impact of a national program to eliminate lymphatic filariasis in selected Myanmar immigrant communities in Bangkok and Ranong Province, Thailand. (22299429)
2011
13
Cutaneous angiosarcoma in chronic lymphedema: secondary to filariasis. (23024552)
2011
14
First evidence of spatial clustering of lymphatic filariasis in an Aedes polynesiensis endemic area. (21172296)
2011
15
Filariasis presenting as multiple subcutaneous nodules: a rare case report. (22156357)
2011
16
The Global Programme to Eliminate Lymphatic Filariasis: History and achievements with special reference to annual single-dose treatment with diethylcarbamazine in Samoa and Fiji. (22028608)
2011
17
Screening mosquito house entry points as a potential method for integrated control of endophagic filariasis, arbovirus and malaria vectors. (20689815)
2010
18
Association between Toll-like receptor 2 (TLR2) polymorphisms and asymptomatic bancroftian filariasis. (20549240)
2010
19
Bancroftian filariasis among the Mbembe people of Cross River state, Nigeria. (20539046)
2010
20
Absence of lymphatic filariasis infection among secondary-school children in Oman. (21222423)
2010
21
Studies of Anopheles gambiae s.l (Diptera: Culicidae) exhibiting different vectorial capacities in lymphatic filariasis transmission in the Gomoa district, Ghana. (20840757)
2010
22
Lymphatic filariasis control in Tanzania: effect of repeated mass drug administration with ivermectin and albendazole on infection and transmission. (20532226)
2010
23
Seroprevalence of lymphatic filariasis at Puducherry. (21526028)
2010
24
Lymphatic filariasis in children: age dependent prevalence in an area of India endemic for Wuchereria bancrofti infection. (20562812)
2010
25
The sharp end - experiences from the Tanzanian programme for the elimination of lymphatic filariasis: notes from the end of the road. (19843398)
2009
26
Spinal lymphoma and pulmonary filariasis in a pet domestic rabbit (Oryctolagus cuniculus domesticus). (19286509)
2009
27
Filariasis due to blood transfusion: a topic in tropical medicine. (19503636)
2009
28
GlaxoSmithKline and Merck: private-sector collaboration for the elimination of lymphatic filariasis. (19843393)
2009
29
The development of albendazole for lymphatic filariasis. (19843396)
2009
30
Social deprivation index and lymphatic filariasis: a tool for mapping urban areas at risk in northeastern Brazil. (24036297)
2009
31
Impact of seven rounds of mass administration of diethylcarbamazine and ivermectin on prevalence of chronic lymphatic filariasis in south India. (18346027)
2008
32
The global programme to eliminate lymphatic filariasis: health impact after 8 years. (18841205)
2008
33
Mass drug administration trial to eliminate lymphatic filariasis in Papua New Guinea: changes in microfilaremia, filarial antigen, and Bm14 antibody after cessation. (18256431)
2008
34
Prevention of lymphatic filariasis with insecticide-treated bednets in Cambodia. (18318935)
2008
35
The geographical distribution of lymphatic filariasis infection in Malawi. (18047646)
2007
36
Unfulfilled potential: using diethylcarbamazine-fortified salt to eliminate lymphatic filariasis. (17768503)
2007
37
Kinetics of microfilaraemia & antigenaemia status by Og(4)C(3) ELISA in bancroftian filariasis. (18219085)
2007
38
Personal-protection measures against mosquitoes: a study of practices and costs in a district, in the Indian state of Orissa, where malaria and lymphatic filariasis are co-endemic. (17877879)
2007
39
Lymphatic Filariasis (Elephantiasis) Elimination: A public health success and development opportunity. (13129436)
2003
40
Treatment of co-infection with bancroftian filariasis and onchocerciasis: a safety and efficacy study of albendazole with ivermectin compared to treatment of single infection with bancroftian filariasis. (14613509)
2003
41
Mass drug treatment for lymphatic filariasis and onchocerciasis. (14580963)
2003
42
Lymphatic filariasis elimination and schistosomiasis control in combination with onchocerciasis control in Nigeria. (12408665)
2002
43
B-cell deficiency suppresses vaccine-induced protection against murine filariasis but does not increase the recovery rate for primary infection. (11598082)
2001
44
Tropical pulmonary eosinophilia and filariasis in Pakistan. (11485099)
2001
45
Differential antibody isotype reactivity to specific antigens in human lymphatic filariasis: gp15/400 preferentially induces immunoglobulin E (IgE), IgG4, and IgG2. (7558279)
1995
46
Differential expression of IgE and IgG4 specific antibody responses in asymptomatic and chronic human filariasis. (8473742)
1993
47
Immune complex glomerulonephritis and chronic anaerobic urinary infection--complications of filariasis. (6227878)
1983
48
Protein-losing enteropathy possible due to filariasis. (5346171)
1969
49
ELECTROPHORETIC STUDY ON THE PROTEIN CONTENT OF SERUM AND HYDROCELE FLUID IN FILARIASIS. (14073718)
1963
50
Occult filariasis: its relatioship with tropical pulmonary eosinophilia. (13957795)
1962

Genetic Variations for Filariasis

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Expression for genes affiliated with Filariasis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Filariasis

Search GEO for disease gene expression data for Filariasis.

Pathways for genes affiliated with Filariasis

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29KEGG, 52R&D Systems, 37NCBI BioSystems Database, 51QIAGEN, 4Cell Signaling Technology, 12EMD Millipore, 53Reactome, 59Tocris Bioscience, 55SinoBiological
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Pathways related to Filariasis according to GeneCards/GeneDecks:

(show all 24)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.3TLR2, TLR4
210.3IL13, IL5
310.2TLR4, TLR2, IL10
410.2IL5, IL10, IL13
510.2IL13, IL10, IL5
610.2IL13, IL10, IL5
710.2TLR4, TLR2, TLR1
8
Immune response Bacterial infections in normal airways
10.2TLR1, TLR2, TLR4
9
Hide members
10.2TLR4, TLR2, TLR1
1010.2TLR1, TLR2, TLR4
1110.2TLR4, TLR2, TLR1
12
Hide members
10.2TLR1, TLR2, TLR4
1310.2IL5, IL10, IGHE
1410.1TLR4, TLR2, TLR1, IL10
15
Hide members
10.1TLR4, TLR2, TLR1, IL10
16
Hide members
10.1IL10, TLR1, TLR2, TLR4
17
Hide members
10.1IL5, IL10, IL13, ICOS
18
Hide members
10.1TNFRSF18, TLR1, TLR2, TLR4
19
Hide members
10.0TLR4, TLR2, IL13, IL10, IL5
20
Hide members
10.0IL5, IL13, TLR1, TLR2, TLR4
21
Hide members
10.0TLR4, TLR2, TLR1, TNFRSF18, CD27
22
Hide members
9.9TLR4, TLR2, TLR1, ICOS, IGHE, IL5
23
Hide members
9.8TLR4, TLR2, TLR1, TNFRSF18, IL13, IL10
24
Hide members
9.8TLR4, TNFRSF18, PPP1R14B, CD27, IL13, IL10

Compounds for genes affiliated with Filariasis

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44Novoseek, 28IUPHAR, 59Tocris Bioscience, 2BitterDB, 11DrugBank, 49PharmGKB, 24HMDB
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Compounds related to Filariasis according to GeneCards/GeneDecks:

(show top 50)    (show all 80)
idCompoundScoreTop Affiliating Genes
1amphotericin b4410.8IL13
2cyclosporin a44 28 5912.8IGHE
3cycloheximide4410.7TLR2
4rantes4410.7TLR2, TLR4
5hydrocortisone44 2 59 1113.7IGHE
6pam3csk45910.6TLR1, TLR2, TLR4
7pam2csk45910.6TLR2, TLR1, TLR4
8poly(i:c)5910.6TLR4, TLR2, TLR1
9glucuronoxylomannan4410.6TLR4, TLR2, IL10
10omalizumab44 1111.6IL5, IL13, IGHE
11gm-csf44 2811.6IL10
12resiquimod44 5911.6TLR1, TLR4, TLR2
13trimellitic anhydride4410.6IGHE, IL13
14ovomucoid4410.6IL5, IGHE, IL13
15glatiramer acetate44 1111.6IL10, IL5, IL13
16arabinogalactan4410.6TLR4, TLR2
17as 10159 4411.6IL13, IL10, IL5
18penicillin4410.6IL5, IL13, IGHE
19il-124410.6IL13, IL10, IL5
20flagellin44 2811.6TLR1, TLR2, TLR4
21p 2774410.6TLR2, IL10
22polyinosinic-polycytidylic acid4410.5TLR4, IL10, TLR2, IL5
23praziquantel44 1111.5IL5, IGHE, IL13, IL10
24methyltetrahydrophthalic anhydride4410.5IL13, IGHE
25montelukast44 49 28 1113.5IL13, IL5, IL10, IGHE
26lipoteichoic acid4410.5TLR4, TLR2, TLR1, IL10
27salbutamol44 49 28 11 2414.5IL10, IL5, IGHE, IL13
28ccl344 2811.5IL13, IL10, TLR4, TLR2
29peptidoglycan44 2811.5TLR1, TLR2, IL10, TLR4
30tarc4410.5IL13, IL5, IGHE, IL10
31polymyxin b4410.5IL10, TLR2, TLR4
32il 104410.5IL5, IL10, IL13, TLR4, TLR2
33imiquimod44 28 59 1113.5TLR4, TLR1, IL5, TLR2, IL10
34allergens4410.5IL5, IL13, TLR4, IGHE, IL10
35tacrolimus44 49 1112.4TLR2, TLR4, IL13, IL5, IL10
36budesonide44 49 1112.4IL5, IGHE, IL13
37prednisolone44 28 1112.4IL10, IL13, IGHE, IL5
38fluticasone propionate44 49 59 1113.4IL5, IGHE, IL13
39sb 20358044 5911.4IL5, TLR4, TLR2, IL13, IL10
40polysaccharide4410.3TLR4, TLR2, CHIT1, IL13, IGHE
41histamine44 28 2412.3IGHE, IL5, IL10, TLR2, IL13, TLR4
42vitamin d4410.3TLR4, TLR2, IL10, IGHE, IL5
43mannose4410.3TLR4, CHIT1, IL13, TLR2
44thyroxine44 2411.3IGHE, IL13, IL10, IL5
45pgd24410.3IGHE, IL13, IL5
46ionomycin4410.2IL13, IL5, IL10, TLR2
47poly(i-c)4410.1IL5, TLR4, TLR2
48diaminopimelic acid4410.0TLR4, TLR2
49dexamethasone44 49 28 1112.9TLR2, IGHE, IL13, IL10, IL5, TLR4
50vegf449.9IL13, IGHE, TLR2, TLR4, IL5, IL10

GO Terms for genes affiliated with Filariasis

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16Gene Ontology
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Cellular components related to Filariasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Toll-like receptor 1-Toll-like receptor 2 protein complexGO:03535410.0TLR1, TLR2
2integral to plasma membraneGO:0058879.9TLR4, TLR2, TLR1, ICOS, TNFRSF18, CD27
3external side of plasma membraneGO:0098979.8CD27, TLR4, TLR2, ICOS, TNFRSF18, IL13

Biological processes related to Filariasis according to GeneCards/GeneDecks:

(show all 20)
idNameGO IDScoreTop Affiliating Genes
1detection of triacyl bacterial lipopeptideGO:04249510.6TLR1, TLR2
2cellular response to triacyl bacterial lipopeptideGO:07172710.6TLR1, TLR2
3detection of diacyl bacterial lipopeptideGO:04249610.6TLR2, TLR1
4positive regulation of macrophage cytokine productionGO:06090710.6TLR2, TLR4
5cellular response to lipoteichoic acidGO:07122310.5TLR4, TLR2
6positive regulation of tumor necrosis factor biosynthetic processGO:04253510.5TLR1, TLR2, TLR4
7I-kappaB phosphorylationGO:00725210.5TLR4, TLR2, PRDX4
8regulation of cytokine secretionGO:05070710.5TLR4, TLR1
9positive regulation of MHC class II biosynthetic processGO:04534810.5TLR4, IL10
10positive regulation of B cell proliferationGO:03089010.5IL5, IL13, TLR4
11negative regulation of interleukin-17 productionGO:03270010.5TLR2, TLR4
12macrophage activationGO:04211610.4TLR1, TLR4
13positive regulation of nitric-oxide synthase biosynthetic processGO:05177010.4TLR2, TLR4
14inflammatory responseGO:00695410.3TLR2, TLR1, IL13, IL10, IL5
15MyD88-dependent toll-like receptor signaling pathwayGO:00275510.3TLR4, TLR2, TLR1
16positive regulation of chemokine productionGO:03272210.3TLR2, TLR4
17negative regulation of interleukin-12 productionGO:03269510.3IL10, TLR2
18T-helper 1 type immune responseGO:04208810.2TLR4, TLR1
19immune responseGO:00695510.1IL5, TLR4, TLR2, TLR1, ICOS, CHIT1
20negative regulation of growth of symbiont in hostGO:04413010.0IL10, TLR2

Molecular functions related to Filariasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1lipopolysaccharide receptor activityGO:00187510.3TLR2, TLR4
2transmembrane signaling receptor activityGO:0048889.8CD27, TLR1, TLR2, TLR4

Products for genes affiliated with Filariasis

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  • Antibodies
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  • Antibodies

Sources for Filariasis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet