MCID: FLR002
MIFTS: 50

Filariasis malady

Infectious diseases category

Summaries for Filariasis

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Disease Ontology:9 A parasitic helminthiasis infectious disease that involves parasitic infection of the lymphatics and subcutaneous tissue by nematodes of the superfamily filarioidea.

MalaCards based summary: Filariasis, also known as disease due to superfamily filarioidea, is related to schistosomiasis and malaria. An important gene associated with Filariasis is CHIT1 (chitinase 1 (chitotriosidase)), and among its related pathways are Selected targets of GCR alpha and MSP-RON Signaling. The compounds arabinogalactan and diaminopimelic acid have been mentioned in the context of this disorder. Affiliated tissues include testes, breast and t cells, and related mouse phenotypes are tumorigenesis and liver/biliary system.

Wikipedia:63 Filariasis (or philariasis) is a parasitic disease caused by an infection with roundworms of the... more...

Aliases & Classifications for Filariasis

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Sources:
9Disease Ontology, 11DISEASES, 43Novoseek, 60UMLS, 55SNOMED-CT, 33MeSH, 27ICD9CM, 38NCIt, 25ICD10
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Filariasis, Aliases & Descriptions:

Name: Filariasis 9 11 43 60
 
Disease Due to Superfamily Filarioidea 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases


External Ids:

Disease Ontology9 DOID:1080
MeSH33 D005368
ICD9CM27 125.9
NCIt38 C34611

Related Diseases for Filariasis

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Diseases related to Filariasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 124)
idRelated DiseaseScoreTop Affiliating Genes
1schistosomiasis31.0IL5, IL13
2malaria30.9TLR2, CHIT1, IL10
3leprosy30.8TLR2
4pulmonary eosinophilia30.7IL5, IL13
5eosinophilia30.3IL13, IL10, IL5
6gastritis30.0TLR2, TLR4
7leishmaniasis29.7IL13, IL10, IL5
8arthritis29.3TLR2, TLR4, IL10, IL13
9rheumatoid arthritis29.0TLR2, TLR4, IL10, IL13, CD27
10onchocerciasis10.7
11filarial elephantiasis10.6
12hydrocele10.6
13elephantiasis10.5
14eosinophilic fasciitis10.5IL5
15esophagitis, eosinophilic, 110.5IL5
16loiasis10.4
17lymphedema10.4
18meningitis10.4TLR2
19intestinal volvulus10.3TLR2, IL5
20aspergillosis10.2TLR2, TLR4
21colorectal cancer10.2TLR2, TLR4
22invasive aspergillosis10.2TLR2, TLR4
23blindness10.2
24pouchitis10.2TLR2, TLR4
25melioidosis10.2TLR2, TLR4
26neisseria meningitidis infection10.2TLR2, TLR4
27parasitic helminthiasis infectious disease10.2IL5, IL13
28chorioamnionitis10.2TLR2, TLR4
29allergic conjunctivitis10.2IL5, IL13
30mastitis10.2TLR2, TLR4
31keratoconjunctivitis10.2IL5, IL13
32eosinophilic pneumonia10.2IL5, IL13
33periodontitis10.2TLR2, TLR4
34asthma10.2IL5, IL13
35allergic rhinitis10.2IL5, IL13
36food allergy10.2IL5, IL13
37keratitis10.2TLR4, TLR2
38vernal keratoconjunctivitis10.2IL13, IL5
39malt lymphoma10.2TLR2, TLR4
40esophagitis10.2IL5, IL13
41strongyloidiasis10.2
42mansonelliasis10.2
43dirofilariasis10.2
44endomyocardial fibrosis10.2
45podoconiosis10.2
46mastocytosis10.2IL13, IL5
47psoriatic arthritis10.1TLR2, IL13
48bullous pemphigoid10.1IL13, IL5
49rhinitis10.1IL5, IL13
50lepromatous leprosy10.1TLR2, IL10

Graphical network of the top 20 diseases related to Filariasis:



Diseases related to filariasis

Symptoms for Filariasis

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Drugs & Therapeutics for Filariasis

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Drug clinical trials:

Search ClinicalTrials for Filariasis

Search NIH Clinical Center for Filariasis

Genetic Tests for Filariasis

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Anatomical Context for Filariasis

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MalaCards organs/tissues related to Filariasis:

31
Testes, Breast, T cells, B cells, Kidney, Endothelial

Animal Models for Filariasis or affiliated genes

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MGI Mouse Phenotypes related to Filariasis:

35 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.4IL10, IL5, TLR4, TLR2
2MP:00053708.4TLR2, TLR4, IL5, IL10
3MP:00053898.1IL13, IL10, IL5, TLR4
4MP:00107718.0TLR2, TLR4, IL10, IL13
5MP:00053887.8TLR2, TLR4, IL5, IL10, IL13
6MP:00053817.8TLR2, TLR4, IL5, IL10, IL13
7MP:00053787.6TLR2, TLR4, IL5, IL10, IL13
8MP:00053847.6CD27, IL13, IL10, TLR4, TLR2
9MP:00053767.3TLR2, TLR4, IL5, IL10, IL13
10MP:00053977.3TLR2, TLR4, IL5, IL10, IL13, CD27
11MP:00053877.0CD27, TLR2, TLR4, CHIT1, IL5, IL10

Publications for Filariasis

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Articles related to Filariasis:

(show top 50)    (show all 616)
idTitleAuthorsYear
1
Synthesis and characterization of silver nanoparticles using Gmelina asiatica leaf extract against filariasis, dengue, and malaria vector mosquitoes. (25666372)
2015
2
Ongoing surveillance for lymphatic filariasis in togo: assessment of alternatives and nationwide reassessment of transmission status. (24189363)
2014
3
Evaluation of the Og34C filter paper technique in lymphatic filariasis prevalence studies. (25282872)
2014
4
Lymphatic filariasis: A view at pathological diversity. (25250237)
2014
5
Lymphatic filariasis control in Tanga Region, Tanzania: status after eight rounds of mass drug administration. (25387483)
2014
6
Evaluation of Brugia malayi sheath protein (Shp-1) as a diagnostic antigen for human lymphatic filariasis. (24389369)
2013
7
Will mass drug administration eliminate lymphatic filariasis? Evidence from northern coastal Tanzania. (23014581)
2013
8
Insights into the pathogenesis of disease in human lymphatic filariasis. (24044755)
2013
9
Therapeutic efficacy of poly (lactic-co-glycolic acid) nanoparticles encapsulated ivermectin (nano-ivermectin) against brugian filariasis in experimental rodent model. (24366812)
2013
10
Impact of three rounds of mass drug administration on lymphatic filariasis in areas previously treated for onchocerciasis in Sierra Leone. (23785535)
2013
11
Urban lymphatic filariasis in the city of Tanga, Tanzania, after seven rounds of mass drug administration. (24135628)
2013
12
Malaria and lymphatic filariasis: the case for integrated vector management. (23084831)
2013
13
Long-lasting insecticidal nets are synergistic with mass drug administration for interruption of lymphatic filariasis transmission in Nigeria. (24205421)
2013
14
Rapid assessment procedure for loiasis and mapping lymphatic filariasis: two perfect illustrations of "to be in English or not to be". (23272254)
2012
15
Larvicidal efficacy of Adhatoda vasica (L.) Nees against the bancroftian filariasis vector Culex quinquefasciatus Say and dengue vector Aedes aegypti L. in in vitro condition. (22167370)
2012
16
Cost-effective antigen testing for delimitation, monitoring and evaluation in bancroftian filariasis. (22290349)
2012
17
Studies on Fungal Cultural Filtrates against Adult Culex quinquefasciatus (Diptera: Culicidae) a Vector of Filariasis. (22132305)
2011
18
Epidemiological assessment of continuing transmission of lymphatic filariasis in Samoa. (22325816)
2011
19
Progress toward elimination of lymphatic filariasis--Togo, 2000--2009. (21796097)
2011
20
Application of the Filariasis CELISA Antifilarial IgG(4) Antibody Assay in Surveillance in Lymphatic Filariasis Elimination Programmes in the South Pacific. (21961018)
2011
21
The "filarial dance" is not characteristic of filariasis: observations of "dancing megasperm" on high-resolution sonography in patients from nonendemic areas mimicking the filarial dance and a proposed mechanism for this phenomenon. (21795491)
2011
22
Zoonotic Brugia pahangi filariasis in a suburbia of Kuala Lumpur City, Malaysia. (20951228)
2011
23
A rare case of reversible acquired AA-type renal amyloidosis in a chronic filariasis patient receiving antifilarial therapy. (21519822)
2011
24
Lymphatic filariasis. (21972476)
2011
25
Antigen detection assay with parasite specific monoclonal antibodies for diagnosis of lymphatic filariasis. (21741373)
2011
26
Flubendazole: a candidate macrofilaricide for lymphatic filariasis and onchocerciasis field programs. (21609260)
2011
27
The impact of a national program to eliminate lymphatic filariasis in selected Myanmar immigrant communities in Bangkok and Ranong Province, Thailand. (22299429)
2011
28
Cutaneous angiosarcoma in chronic lymphedema: secondary to filariasis. (23024552)
2011
29
Geographic and ecologic heterogeneity in elimination thresholds for the major vector-borne helminthic disease, lymphatic filariasis. (20236528)
2010
30
Association between Toll-like receptor 2 (TLR2) polymorphisms and asymptomatic bancroftian filariasis. (20549240)
2010
31
The sharp end - experiences from the Tanzanian programme for the elimination of lymphatic filariasis: notes from the end of the road. (19843398)
2009
32
A pilot program of mass surgery weeks for treatment of hydrocele due to lymphatic filariasis in central Nigeria. (19270297)
2009
33
Ten years of managing the clinical manifestations and disabilities of lymphatic filariasis. (19843392)
2009
34
Nigeria's war on terror: fighting dracunculiasis, onchocerciasis, lymphatic filariasis, and schistosomiasis at the grassroots. (19407107)
2009
35
Global programme to eliminate lymphatic filariasis. (18788146)
2008
36
Impact of seven rounds of mass administration of diethylcarbamazine and ivermectin on prevalence of chronic lymphatic filariasis in south India. (18346027)
2008
37
An unusual presentation of filariasis: a case report. (18499995)
2008
38
Eliminating lymphatic filariasis: a view from the field. (18579875)
2008
39
Pharmacovigilance through consumer feedback (reporting) in the mass treatment of lymphatic filariasis using diethylcarbamazine and albendazole in two districts of Sri Lanka. (18631319)
2008
40
National mass drug administration costs for lymphatic filariasis elimination. (17989784)
2007
41
Confirmation of elimination of lymphatic filariasis by an IgG4 enzyme-linked immunosorbent assay with urine samples in Yongjia, Zhejiang Province and Gaoan, Jiangxi Province, People's Republic of China. (17690407)
2007
42
Epidemiological modelling for monitoring and evaluation of lymphatic filariasis control. (18063097)
2007
43
A critical appraisal of molecular xenomonitoring as a tool for assessing progress toward elimination of Lymphatic Filariasis. (17978055)
2007
44
Effect of diethylcarbamazine on HIV load, CD4%, and CD4/CD8 ratio in HIV-infected adult Tanzanians with or without lymphatic filariasis: randomized double-blind and placebo-controlled cross-over trial. (17827369)
2007
45
Plasma vascular endothelial growth Factor-A (VEGF-A) and VEGF-A gene polymorphism are associated with hydrocele development in lymphatic filariasis. (17978056)
2007
46
Ocular filariasis due to Wuchereria bancrofti presenting as panuveitis: a case report. (14533034)
2003
47
Serum levels of endothelin-1 (ET-1), interleukin-2 (IL-2) and amino-terminal propeptide type III procollagen (PIII NP) in patients with acute and chronic filariasis. (12557940)
2001
48
Infectious diseases: filariasis, Malayan filariasis, loiasis (ioa ioa), Onchocerciasis (river blindness). (11930850)
2001
49
Renal disease in lymphatic filariasis: evidence for tubular and glomerular disorders at various stages of the infection. (9315046)
1997
50
Treatment of elephantiasis in a community with timorian filariasis. (3992641)
1985

Variations for Filariasis

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Expression for genes affiliated with Filariasis

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Search GEO for disease gene expression data for Filariasis.

Pathways for genes affiliated with Filariasis

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Pathways related to Filariasis according to GeneCards Suite gene sharing:

(show all 33)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5TLR4, TLR2
29.5TLR4, TLR2
39.5TLR2, TLR4
4
Show member pathways
9.5TLR2, TLR4
5
Show member pathways
Transcription NF kB signaling pathway58
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response58
9.5TLR4, TLR2
6
Show member pathways
9.5TLR4, TLR2
79.5TLR4, TLR2
89.5TLR4, TLR2
99.4IL5, IL13
109.4IL5, IL13
119.2IL10, IL5
129.2IL10, IL5
139.1IL10, TLR4
149.1IL10, TLR4
15
Show member pathways
9.0CD27, TLR4, TLR2
16
Show member pathways
8.9TLR2, TLR4, IL13
178.7TLR2, TLR4, IL10
18
Show member pathways
Toll-like receptor signaling pathway36
Regulation of toll-like receptor signaling pathway36
8.7TLR2, TLR4, IL10
198.7IL10, TLR4, TLR2
20
Show member pathways
IL27-mediated signaling events36
8.7IL10, TLR4, TLR2
218.7TLR2, TLR4, IL10
228.6IL5, IL10, IL13
23
Show member pathways
8.6IL5, IL10, IL13
24
Show member pathways
8.6IL5, IL10, IL13
25
Show member pathways
Type III interferon signaling36
8.6IL5, IL10, IL13
268.6IL13, IL10, IL5
278.6IL13, IL10, IL5
28
Show member pathways
8.6IL13, IL10, IL5
29
Show member pathways
8.5TLR2, TLR4, IL5, IL13
30
Show member pathways
7.6TLR2, TLR4, IL5, IL10, IL13
31
Show member pathways
7.6IL13, IL10, IL5, TLR4, TLR2
32
Show member pathways
7.6TLR4, IL5, IL10, IL13, CD27

Compounds for genes affiliated with Filariasis

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Compounds related to Filariasis according to GeneCards Suite gene sharing:

(show top 50)    (show all 112)
idCompoundScoreTop Affiliating Genes
1arabinogalactan439.8TLR2, TLR4
2diaminopimelic acid439.7TLR2, TLR4
3poly(i:c)599.6TLR4, TLR2
4pam3csk4599.6TLR4, TLR2
5pam2csk4599.5TLR4, TLR2
6p 277439.5TLR2, IL10
7poly(i-c)439.4IL5, TLR4, TLR2
8amphotericin b439.4TLR2, IL5, IL13
9anti-fungal439.4TLR4, IL5, TLR2
10loxoribine43 2810.4TLR2, TLR4
11omalizumab43 1210.1IL5, IL13
12glucuronoxylomannan439.1IL10, TLR2, TLR4
13polymyxin b439.1TLR2, TLR4, IL10
14glatiramer acetate43 1210.0IL13, IL10, IL5
15praziquantel43 1210.0IL13, IL5, IL10
16lipoteichoic acid439.0TLR2, TLR4, IL10
17as 10143 5910.0IL10, IL13, IL5
18il-12439.0IL5, IL10, IL13
19montelukast43 49 28 1212.0IL5, IL10, IL13
20gm-csf43 2810.0IL10, IL13, IL5
21leukotriene b443 59 2411.0TLR2, IL13, IL5
22salbutamol43 49 28 24 1213.0IL10, IL5, IL13
23peptidoglycan43 2810.0IL10, TLR4, TLR2
24rolipram43 59 2811.0IL13, IL5, IL10
25tarc438.9IL10, IL5, IL13
26mannose438.9TLR4, TLR2, IL13, CHIT1
27polysaccharide438.8TLR2, IL13, CHIT1, TLR4
28theophylline43 28 24 1211.8IL13, IL5, IL10
29thalidomide43 49 59 1211.8IL13, IL10, IL5
30ifn-alpha438.8TLR4, IL13, IL10
31imiquimod43 59 28 1211.7IL10, IL5, TLR4, TLR2
32polyinosinic-polycytidylic acid438.7TLR4, IL5, TLR2, IL10
33vitamin d438.6TLR2, TLR4, IL5, IL10
34ionomycin438.6IL10, IL13, TLR2, IL5
35allergens438.5TLR4, IL5, IL10, IL13
36ccl343 289.5IL13, IL10, TLR4, TLR2
37endotoxin438.4IL10, TLR2, IL13, TLR4
38calcitriol43 59 24 1211.4TLR2, IL10, TLR4, IL13
39ly294002438.4IL13, TLR4, IL10, IL5
40cysteine438.2IL13, TLR2, TLR4, IL5, CD27
41il 10438.1TLR4, IL10, TLR2, IL5, IL13
42tacrolimus43 49 1210.1TLR4, IL10, IL13, TLR2, IL5
43rantes438.1IL13, IL5, TLR4, TLR2, IL10
44sb 20358043 599.1TLR4, IL13, IL10, IL5, TLR2
45histamine43 28 2410.1TLR2, IL13, IL5, TLR4, IL10
46cyclosporin a43 28 5910.1IL10, IL13, IL5, TLR4, TLR2
47pge2438.1IL10, IL5, TLR4, TLR2, IL13
48cycloheximide438.1IL13, IL10, IL5, TLR2, TLR4
49dexamethasone43 49 28 1211.0TLR2, TLR4, IL5, IL10, IL13
50vegf438.0TLR2, IL5, TLR4, IL13, IL10

GO Terms for genes affiliated with Filariasis

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Cellular components related to Filariasis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00056158.2IL13, IL10, IL5, CHIT1
2external side of plasma membraneGO:00098978.1CD27, IL13, TLR4, TLR2

Biological processes related to Filariasis according to GeneCards Suite gene sharing:

(show all 38)
idNameGO IDScoreTop Affiliating Genes
1cellular response to lipoteichoic acidGO:00712239.9TLR2, TLR4
2positive regulation of macrophage cytokine productionGO:00609079.9TLR2, TLR4
3negative regulation of interleukin-17 productionGO:00327009.9TLR4, TLR2
4positive regulation of tumor necrosis factor biosynthetic processGO:00425359.9TLR2, TLR4
5I-kappaB phosphorylationGO:00072529.9TLR4, TLR2
6positive regulation of nitric-oxide synthase biosynthetic processGO:00517709.9TLR4, TLR2
7positive regulation of chemokine productionGO:00327229.9TLR2, TLR4
8positive regulation of interleukin-10 productionGO:00327339.9TLR4, TLR2
9positive regulation of NF-kappaB import into nucleusGO:00423469.9TLR2, TLR4
10positive regulation of interleukin-8 productionGO:00327579.9TLR4, TLR2
11positive regulation of interferon-beta productionGO:00327289.8TLR2, TLR4
12positive regulation of interleukin-12 productionGO:00327359.8TLR4, TLR2
13lipopolysaccharide-mediated signaling pathwayGO:00316639.8TLR4, TLR2
14positive regulation of nitric oxide biosynthetic processGO:00454299.8TLR2, TLR4
15positive regulation of tumor necrosis factor productionGO:00327609.8TLR4, TLR2
16positive regulation of interleukin-6 productionGO:00327559.8TLR4, TLR2
17positive regulation of inflammatory responseGO:00507299.8TLR4, TLR2
18toll-like receptor TLR6:TLR2 signaling pathwayGO:00381249.7TLR2, TLR4
19positive regulation of JNK cascadeGO:00463309.7CD27, TLR4
20toll-like receptor TLR1:TLR2 signaling pathwayGO:00381239.6TLR2, TLR4
21negative regulation of interleukin-12 productionGO:00326959.6IL10, TLR2
22negative regulation of growth of symbiont in hostGO:00441309.6TLR2, IL10
23toll-like receptor 2 signaling pathwayGO:00341349.6TLR4, TLR2
24positive regulation of MHC class II biosynthetic processGO:00453489.5TLR4, IL10
25cellular response to mechanical stimulusGO:00712609.5IL13, TLR4
26positive regulation of cytokine secretionGO:00507159.5TLR2, IL10
27MyD88-dependent toll-like receptor signaling pathwayGO:00027559.5TLR4, TLR2
28toll-like receptor 4 signaling pathwayGO:00341429.5TLR4, TLR2
29negative regulation of interleukin-6 productionGO:00327159.5IL10, TLR4
30negative regulation of interferon-gamma productionGO:00326899.5TLR4, IL10
31response to insulinGO:00328689.4TLR2, IL10
32negative regulation of tumor necrosis factor productionGO:00327209.4TLR4, IL10
33positive regulation of B cell proliferationGO:00308909.3TLR4, IL5, IL13
34cellular response to lipopolysaccharideGO:00712229.2TLR4, IL10
35response to ethanolGO:00454719.2IL13, CD27
36positive regulation of sequence-specific DNA binding transcription factor activityGO:00510918.9IL10, IL5
37inflammatory responseGO:00069548.6TLR2, IL5, IL10, IL13
38immune responseGO:00069558.5IL13, IL5, CHIT1, TLR4, TLR2

Molecular functions related to Filariasis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1lipopolysaccharide receptor activityGO:00018759.4TLR4, TLR2
2transmembrane signaling receptor activityGO:00048888.7CD27, TLR4, TLR2
3cytokine activityGO:00051258.6IL13, IL10, IL5

Products for genes affiliated with Filariasis

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Sources for Filariasis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet