MCID: FLR002
MIFTS: 58

Filariasis malady

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Summaries for Filariasis

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Disease Ontology:8 A parasitic helminthiasis infectious disease that involves parasitic infection of the lymphatics and subcutaneous tissue by nematodes of the superfamily filarioidea.

MalaCards based summary: Filariasis, also known as disease due to superfamily filarioidea, is related to malaria and leprosy. An important gene associated with Filariasis is CHIT1 (chitinase 1 (chitotriosidase)), and among its related pathways are Selected targets of GCR alpha and MSP-RON Signaling. The compounds arabinogalactan and diaminopimelic acid have been mentioned in the context of this disorder. Affiliated tissues include testes, breast and t cells, and related mouse phenotypes are tumorigenesis and liver/biliary system.

Wikipedia:65 Filariasis (or philariasis) is a parasitic disease that is caused by thread-like roundworms belonging to... more...

Aliases & Classifications for Filariasis

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 62UMLS, 34MeSH, 57SNOMED-CT, 27ICD9CM, 39NCIt, 25ICD10
See all sources

Filariasis, Aliases & Descriptions:

Name: Filariasis 8 10 44 62
 
Disease Due to Superfamily Filarioidea 8 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases


External Ids:

Disease Ontology8 DOID:1080
MeSH34 D005368
ICD9CM27 125.9
NCIt39 C34611

Related Diseases for Filariasis

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Diseases related to Filariasis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 125)
idRelated DiseaseScoreTop Affiliating Genes
1malaria30.9TLR2, IL10, CHIT1
2leprosy30.8TLR2
3helminthiasis30.8IL5, IL13
4pulmonary eosinophilia30.8IL13, IL5
5schistosomiasis30.5IL13, IL10, IL5
6eosinophilia30.3IL13, IL5, IL10
7gastritis30.0TLR2, TLR4
8leishmaniasis29.7IL10, IL13, IL5
9arthritis29.3TLR4, TLR2, IL10, IL13
10rheumatoid arthritis29.0TLR4, TLR2, IL10, IL13, CD27
11onchocerciasis10.7
12filarial elephantiasis10.6
13hydrocele10.6
14elephantiasis10.5
15eosinophilic fasciitis10.5IL5
16eosinophilic esophagitis10.5IL5
17loiasis10.4
18lymphedema10.4
19meningitis10.4TLR2
20intestinal volvulus10.3TLR2, IL5
21aspergillosis10.2TLR2, TLR4
22colorectal cancer10.2TLR2, TLR4
23invasive aspergillosis10.2TLR4, TLR2
24pouchitis10.2TLR2, TLR4
25melioidosis10.2TLR4, TLR2
26blindness10.2
27neisseria meningitidis infection10.2TLR2, TLR4
28chorioamnionitis10.2TLR2, TLR4
29allergic conjunctivitis10.2IL5, IL13
30mastitis10.2TLR4, TLR2
31eosinophilic pneumonia10.2IL5, IL13
32keratoconjunctivitis10.2IL5, IL13
33asthma10.2IL13, IL5
34periodontitis10.2TLR4, TLR2
35allergic rhinitis10.2IL5, IL13
36food allergy10.2IL5, IL13
37vernal keratoconjunctivitis10.2IL13, IL5
38keratitis10.2TLR2, TLR4
39malt lymphoma10.2TLR2, TLR4
40esophagitis10.2IL5, IL13
41mastocytosis10.2IL13, IL5
42mansonelliasis10.2
43endomyocardial fibrosis10.2
44podoconiosis10.2
45strongyloidiasis10.2
46psoriatic arthritis10.1IL13, TLR2
47bullous pemphigoid10.1IL13, IL5
48rhinitis10.1IL5, IL13
49lepromatous leprosy10.1IL10, TLR2
50atopic dermatitis10.1TLR2, IL13

Graphical network of the top 20 diseases related to Filariasis:



Diseases related to filariasis

Symptoms for Filariasis

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Drugs & Therapeutics for Filariasis

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Drug clinical trials:

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Genetic Tests for Filariasis

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Anatomical Context for Filariasis

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MalaCards organs/tissues related to Filariasis:

32
Testes, Breast, T cells, Kidney, B cells, Endothelial

Animal Models for Filariasis or affiliated genes

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MGI Mouse Phenotypes related to Filariasis:

36 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.4IL10, IL5, TLR4, TLR2
2MP:00053708.4TLR2, TLR4, IL5, IL10
3MP:00053898.1IL13, IL10, IL5, TLR4
4MP:00107718.0TLR2, TLR4, IL10, IL13
5MP:00053887.8TLR2, TLR4, IL5, IL10, IL13
6MP:00053817.8TLR2, TLR4, IL5, IL10, IL13
7MP:00053787.6TLR2, TLR4, IL5, IL10, IL13
8MP:00053847.6CD27, IL13, IL10, TLR4, TLR2
9MP:00053767.3TLR2, TLR4, IL5, IL10, IL13
10MP:00053977.3TLR2, TLR4, IL5, IL10, IL13, CD27
11MP:00053877.0CD27, TLR2, TLR4, CHIT1, IL5, IL10

Publications for Filariasis

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Articles related to Filariasis:

(show top 50)    (show all 592)
idTitleAuthorsYear
1
Ongoing surveillance for lymphatic filariasis in togo: assessment of alternatives and nationwide reassessment of transmission status. (24189363)
2014
2
Evaluation of the Og34C filter paper technique in lymphatic filariasis prevalence studies. (25282872)
2014
3
Lymphatic filariasis: A view at pathological diversity. (25250237)
2014
4
Lymphatic filariasis control in Tanga Region, Tanzania: status after eight rounds of mass drug administration. (25387483)
2014
5
Evaluation of Brugia malayi sheath protein (Shp-1) as a diagnostic antigen for human lymphatic filariasis. (24389369)
2013
6
Will mass drug administration eliminate lymphatic filariasis? Evidence from northern coastal Tanzania. (23014581)
2013
7
Insights into the pathogenesis of disease in human lymphatic filariasis. (24044755)
2013
8
Therapeutic efficacy of poly (lactic-co-glycolic acid) nanoparticles encapsulated ivermectin (nano-ivermectin) against brugian filariasis in experimental rodent model. (24366812)
2013
9
Impact of three rounds of mass drug administration on lymphatic filariasis in areas previously treated for onchocerciasis in Sierra Leone. (23785535)
2013
10
Malaria and lymphatic filariasis: the case for integrated vector management. (23084831)
2013
11
Long-lasting insecticidal nets are synergistic with mass drug administration for interruption of lymphatic filariasis transmission in Nigeria. (24205421)
2013
12
A comprehensive, model-based review of vaccine and repeat infection trials for filariasis. (23824365)
2013
13
Rapid assessment procedure for loiasis and mapping lymphatic filariasis: two perfect illustrations of "to be in English or not to be". (23272254)
2012
14
Larvicidal efficacy of Adhatoda vasica (L.) Nees against the bancroftian filariasis vector Culex quinquefasciatus Say and dengue vector Aedes aegypti L. in in vitro condition. (22167370)
2012
15
Cost-effective antigen testing for delimitation, monitoring and evaluation in bancroftian filariasis. (22290349)
2012
16
Studies on Fungal Cultural Filtrates against Adult Culex quinquefasciatus (Diptera: Culicidae) a Vector of Filariasis. (22132305)
2011
17
Epidemiological assessment of continuing transmission of lymphatic filariasis in Samoa. (22325816)
2011
18
Progress toward elimination of lymphatic filariasis--Togo, 2000--2009. (21796097)
2011
19
Application of the Filariasis CELISA Antifilarial IgG(4) Antibody Assay in Surveillance in Lymphatic Filariasis Elimination Programmes in the South Pacific. (21961018)
2011
20
The "filarial dance" is not characteristic of filariasis: observations of "dancing megasperm" on high-resolution sonography in patients from nonendemic areas mimicking the filarial dance and a proposed mechanism for this phenomenon. (21795491)
2011
21
Zoonotic Brugia pahangi filariasis in a suburbia of Kuala Lumpur City, Malaysia. (20951228)
2011
22
A rare case of reversible acquired AA-type renal amyloidosis in a chronic filariasis patient receiving antifilarial therapy. (21519822)
2011
23
Lymphatic filariasis. (21972476)
2011
24
Antigen detection assay with parasite specific monoclonal antibodies for diagnosis of lymphatic filariasis. (21741373)
2011
25
Flubendazole: a candidate macrofilaricide for lymphatic filariasis and onchocerciasis field programs. (21609260)
2011
26
The impact of a national program to eliminate lymphatic filariasis in selected Myanmar immigrant communities in Bangkok and Ranong Province, Thailand. (22299429)
2011
27
Cutaneous angiosarcoma in chronic lymphedema: secondary to filariasis. (23024552)
2011
28
Screening mosquito house entry points as a potential method for integrated control of endophagic filariasis, arbovirus and malaria vectors. (20689815)
2010
29
Geographic and ecologic heterogeneity in elimination thresholds for the major vector-borne helminthic disease, lymphatic filariasis. (20236528)
2010
30
Association between Toll-like receptor 2 (TLR2) polymorphisms and asymptomatic bancroftian filariasis. (20549240)
2010
31
The sharp end - experiences from the Tanzanian programme for the elimination of lymphatic filariasis: notes from the end of the road. (19843398)
2009
32
A pilot program of mass surgery weeks for treatment of hydrocele due to lymphatic filariasis in central Nigeria. (19270297)
2009
33
Ten years of managing the clinical manifestations and disabilities of lymphatic filariasis. (19843392)
2009
34
Nigeria's war on terror: fighting dracunculiasis, onchocerciasis, lymphatic filariasis, and schistosomiasis at the grassroots. (19407107)
2009
35
Global programme to eliminate lymphatic filariasis. (18788146)
2008
36
Impact of seven rounds of mass administration of diethylcarbamazine and ivermectin on prevalence of chronic lymphatic filariasis in south India. (18346027)
2008
37
An unusual presentation of filariasis: a case report. (18499995)
2008
38
Eliminating lymphatic filariasis: a view from the field. (18579875)
2008
39
Pharmacovigilance through consumer feedback (reporting) in the mass treatment of lymphatic filariasis using diethylcarbamazine and albendazole in two districts of Sri Lanka. (18631319)
2008
40
National mass drug administration costs for lymphatic filariasis elimination. (17989784)
2007
41
Confirmation of elimination of lymphatic filariasis by an IgG4 enzyme-linked immunosorbent assay with urine samples in Yongjia, Zhejiang Province and Gaoan, Jiangxi Province, People's Republic of China. (17690407)
2007
42
Epidemiological modelling for monitoring and evaluation of lymphatic filariasis control. (18063097)
2007
43
A critical appraisal of molecular xenomonitoring as a tool for assessing progress toward elimination of Lymphatic Filariasis. (17978055)
2007
44
Effect of diethylcarbamazine on HIV load, CD4%, and CD4/CD8 ratio in HIV-infected adult Tanzanians with or without lymphatic filariasis: randomized double-blind and placebo-controlled cross-over trial. (17827369)
2007
45
Plasma vascular endothelial growth Factor-A (VEGF-A) and VEGF-A gene polymorphism are associated with hydrocele development in lymphatic filariasis. (17978056)
2007
46
Ocular filariasis due to Wuchereria bancrofti presenting as panuveitis: a case report. (14533034)
2003
47
Serum levels of endothelin-1 (ET-1), interleukin-2 (IL-2) and amino-terminal propeptide type III procollagen (PIII NP) in patients with acute and chronic filariasis. (12557940)
2001
48
Infectious diseases: filariasis, Malayan filariasis, loiasis (ioa ioa), Onchocerciasis (river blindness). (11930850)
2001
49
Renal disease in lymphatic filariasis: evidence for tubular and glomerular disorders at various stages of the infection. (9315046)
1997
50
Treatment of elephantiasis in a community with timorian filariasis. (3992641)
1985

Variations for Filariasis

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Expression for genes affiliated with Filariasis

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Expression patterns in normal tissues for genes affiliated with Filariasis

Search GEO for disease gene expression data for Filariasis.

Pathways for genes affiliated with Filariasis

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Pathways related to Filariasis according to GeneCards/GeneDecks:

(show all 33)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6IL5, TLR2
29.5TLR4, TLR2
39.5TLR4, TLR2
49.5TLR2, TLR4
5
Show member pathways
9.5TLR2, TLR4
6
Show member pathways
Transcription NF kB signaling pathway60
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response60
9.5TLR4, TLR2
7
Show member pathways
9.5TLR4, TLR2
89.5TLR4, TLR2
99.5TLR4, TLR2
109.4IL5, IL13
119.4IL5, IL13
129.2IL10, IL5
139.2IL10, IL5
149.1IL10, TLR4
159.1IL10, TLR4
16
Show member pathways
9.0CD27, TLR4, TLR2
17
Show member pathways
8.9TLR2, TLR4, IL13
188.7TLR2, TLR4, IL10
19
Show member pathways
Toll-like receptor signaling pathway37
Regulation of toll-like receptor signaling pathway37
8.7TLR2, TLR4, IL10
208.7IL10, TLR4, TLR2
21
Show member pathways
IL27-mediated signaling events37
8.7IL10, TLR4, TLR2
228.7TLR2, TLR4, IL10
238.6IL5, IL10, IL13
24
Show member pathways
8.6IL5, IL10, IL13
25
Show member pathways
8.6IL5, IL10, IL13
26
Show member pathways
Type III interferon signaling37
8.6IL5, IL10, IL13
278.6IL13, IL10, IL5
288.6IL13, IL10, IL5
29
Show member pathways
8.6IL13, IL10, IL5
30
Show member pathways
8.5TLR2, TLR4, IL5, IL13
31
Show member pathways
7.6TLR2, TLR4, IL5, IL10, IL13
32
Show member pathways
7.6IL13, IL10, IL5, TLR4, TLR2
33
Show member pathways
7.6TLR4, IL5, IL10, IL13, CD27

Compounds for genes affiliated with Filariasis

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Compounds related to Filariasis according to GeneCards/GeneDecks:

(show top 50)    (show all 112)
idCompoundScoreTop Affiliating Genes
1arabinogalactan449.8TLR2, TLR4
2diaminopimelic acid449.7TLR2, TLR4
3poly(i:c)619.6TLR4, TLR2
4pam3csk4619.6TLR4, TLR2
5pam2csk4619.5TLR4, TLR2
6p 277449.5TLR2, IL10
7poly(i-c)449.4IL5, TLR4, TLR2
8amphotericin b449.4TLR2, IL5, IL13
9anti-fungal449.4TLR4, IL5, TLR2
10loxoribine44 2810.4TLR2, TLR4
11omalizumab44 1110.1IL5, IL13
12glucuronoxylomannan449.1IL10, TLR2, TLR4
13polymyxin b449.1TLR2, TLR4, IL10
14glatiramer acetate44 1110.0IL13, IL10, IL5
15praziquantel44 1110.0IL13, IL5, IL10
16lipoteichoic acid449.0TLR2, TLR4, IL10
17as 10144 6110.0IL10, IL13, IL5
18il-12449.0IL5, IL10, IL13
19montelukast44 50 28 1112.0IL5, IL10, IL13
20gm-csf44 2810.0IL10, IL13, IL5
21leukotriene b444 61 2411.0TLR2, IL13, IL5
22salbutamol44 50 28 24 1113.0IL10, IL5, IL13
23peptidoglycan44 2810.0IL10, TLR4, TLR2
24rolipram44 61 2811.0IL13, IL5, IL10
25tarc448.9IL10, IL5, IL13
26mannose448.9TLR4, TLR2, IL13, CHIT1
27polysaccharide448.8TLR2, IL13, CHIT1, TLR4
28theophylline44 28 24 1111.8IL13, IL5, IL10
29thalidomide44 50 61 1111.8IL13, IL10, IL5
30ifn-alpha448.8TLR4, IL13, IL10
31imiquimod44 61 28 1111.7IL10, IL5, TLR4, TLR2
32polyinosinic-polycytidylic acid448.7TLR4, IL5, TLR2, IL10
33vitamin d448.6TLR2, TLR4, IL5, IL10
34ionomycin448.6IL10, IL13, TLR2, IL5
35allergens448.5TLR4, IL5, IL10, IL13
36ccl344 289.5IL13, IL10, TLR4, TLR2
37endotoxin448.4IL10, TLR2, IL13, TLR4
38calcitriol44 61 24 1111.4TLR2, IL10, TLR4, IL13
39ly294002448.4IL13, TLR4, IL10, IL5
40cysteine448.2IL13, TLR2, TLR4, IL5, CD27
41il 10448.1TLR4, IL10, TLR2, IL5, IL13
42tacrolimus44 50 1110.1TLR4, IL10, IL13, TLR2, IL5
43rantes448.1IL13, IL5, TLR4, TLR2, IL10
44sb 20358044 619.1TLR4, IL13, IL10, IL5, TLR2
45histamine44 28 2410.1TLR2, IL13, IL5, TLR4, IL10
46cyclosporin a44 28 6110.1IL10, IL13, IL5, TLR4, TLR2
47pge2448.1IL10, IL5, TLR4, TLR2, IL13
48cycloheximide448.1IL13, IL10, IL5, TLR2, TLR4
49dexamethasone44 50 28 1111.0TLR2, TLR4, IL5, IL10, IL13
50vegf448.0TLR2, IL5, TLR4, IL13, IL10

GO Terms for genes affiliated with Filariasis

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Cellular components related to Filariasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.2IL13, IL10, IL5, CHIT1
2external side of plasma membraneGO:0098978.1CD27, IL13, TLR4, TLR2

Biological processes related to Filariasis according to GeneCards/GeneDecks:

(show all 38)
idNameGO IDScoreTop Affiliating Genes
1cellular response to lipoteichoic acidGO:0712239.9TLR2, TLR4
2positive regulation of macrophage cytokine productionGO:0609079.9TLR2, TLR4
3negative regulation of interleukin-17 productionGO:0327009.9TLR4, TLR2
4positive regulation of tumor necrosis factor biosynthetic processGO:0425359.9TLR2, TLR4
5I-kappaB phosphorylationGO:0072529.9TLR4, TLR2
6positive regulation of nitric-oxide synthase biosynthetic processGO:0517709.9TLR4, TLR2
7positive regulation of chemokine productionGO:0327229.9TLR2, TLR4
8positive regulation of interleukin-10 productionGO:0327339.9TLR4, TLR2
9positive regulation of NF-kappaB import into nucleusGO:0423469.9TLR2, TLR4
10positive regulation of interleukin-8 productionGO:0327579.9TLR4, TLR2
11positive regulation of interferon-beta productionGO:0327289.8TLR2, TLR4
12positive regulation of interleukin-12 productionGO:0327359.8TLR4, TLR2
13lipopolysaccharide-mediated signaling pathwayGO:0316639.8TLR4, TLR2
14positive regulation of nitric oxide biosynthetic processGO:0454299.8TLR2, TLR4
15positive regulation of tumor necrosis factor productionGO:0327609.8TLR4, TLR2
16positive regulation of interleukin-6 productionGO:0327559.8TLR4, TLR2
17positive regulation of inflammatory responseGO:0507299.8TLR4, TLR2
18toll-like receptor TLR6:TLR2 signaling pathwayGO:0381249.7TLR2, TLR4
19positive regulation of JNK cascadeGO:0463309.7CD27, TLR4
20toll-like receptor TLR1:TLR2 signaling pathwayGO:0381239.6TLR2, TLR4
21negative regulation of interleukin-12 productionGO:0326959.6IL10, TLR2
22negative regulation of growth of symbiont in hostGO:0441309.6TLR2, IL10
23toll-like receptor 2 signaling pathwayGO:0341349.6TLR4, TLR2
24positive regulation of MHC class II biosynthetic processGO:0453489.5TLR4, IL10
25cellular response to mechanical stimulusGO:0712609.5IL13, TLR4
26positive regulation of cytokine secretionGO:0507159.5TLR2, IL10
27MyD88-dependent toll-like receptor signaling pathwayGO:0027559.5TLR4, TLR2
28toll-like receptor 4 signaling pathwayGO:0341429.5TLR4, TLR2
29negative regulation of interleukin-6 productionGO:0327159.5IL10, TLR4
30negative regulation of interferon-gamma productionGO:0326899.5TLR4, IL10
31response to insulinGO:0328689.4TLR2, IL10
32negative regulation of tumor necrosis factor productionGO:0327209.4TLR4, IL10
33positive regulation of B cell proliferationGO:0308909.3TLR4, IL5, IL13
34cellular response to lipopolysaccharideGO:0712229.2TLR4, IL10
35response to ethanolGO:0454719.2IL13, CD27
36positive regulation of sequence-specific DNA binding transcription factor activityGO:0510918.9IL10, IL5
37inflammatory responseGO:0069548.6TLR2, IL5, IL10, IL13
38immune responseGO:0069558.5IL13, IL5, CHIT1, TLR4, TLR2

Molecular functions related to Filariasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1lipopolysaccharide receptor activityGO:0018759.4TLR4, TLR2
2transmembrane signaling receptor activityGO:0048888.7CD27, TLR4, TLR2
3cytokine activityGO:0051258.6IL13, IL10, IL5

Products for genes affiliated with Filariasis

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Sources for Filariasis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet