MCID: FLR002
MIFTS: 60

Filariasis malady

Infectious diseases category

Summaries for Filariasis

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A parasitic helminthiasis infectious disease that involves parasitic infection of the lymphatics and subcutaneous tissue by nematodes of the superfamily filarioidea.

MalaCards: Filariasis, also known as disease due to superfamily filarioidea, is related to onchocerciasis and malaria. An important gene associated with Filariasis is CHIT1 (chitinase 1 (chitotriosidase)), and among its related pathways are Malaria and IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types. The compounds amphotericin b and cyclosporin a have been mentioned in the context of this disorder. Affiliated tissues include testes, breast and t cells, and related mouse phenotypes are no phenotypic analysis and immune system.

Wikipedia:63 Filariasis (or philariasis) is a parasitic disease that is caused by thread-like roundworms belonging to... more...

Aliases & Classifications for Filariasis

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8Disease Ontology, 10DISEASES, 44Novoseek, 48Orphanet, 60UMLS, 27ICD9CM, 56SNOMED-CT, 39NCIt, 34MeSH, 26ICD10 via Orphanet, 35MESH via Orphanet, 61UMLS via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases


Characteristics (Orphanet epidemiological data):

48
filariasis:
Inheritance: Sporadic; Age of onset: Variable


Aliases & Descriptions:

filariasis 8 10 44 48 60
disease due to superfamily filarioidea 8
filariasis, unspecified 8
unspecified filariasis 8
filariasis nos 8


External Ids:

Disease Ontology8 DOID:1080
ICD9CM27 125.9
NCIt39 C34611
MeSH34 D005368
ICD10 via Orphanet26 B72, B73, B74.0 B74.1, B74.2, B74.3, B74.4, B74.8, B74.9, more
MESH via Orphanet35 D005368
UMLS via Orphanet61 C0016085

Related Diseases for Filariasis

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Filariasis:



Diseases related to filariasis

Clinical Features for Filariasis

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Drugs & Therapeutics for Filariasis

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Filariasis

Drug clinical trials:

Search ClinicalTrials for Filariasis

Search NIH Clinical Center for Filariasis

Search CenterWatch for Filariasis

Genetic Tests for Filariasis

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Anatomical Context for Filariasis

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32MalaCards
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MalaCards organs/tissues related to Filariasis:

32
Testes, Breast, T cells, B cells, Kidney, Endothelial

Animal Models for Filariasis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Filariasis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000301210.2KIF22, IGHE, PRDX4
2MP:00053879.3IL5, TLR4, TLR2, TLR1, ICOS, TNFRSF18
3MP:00053979.3TLR4, TLR2, ICOS, TNFRSF18, IGHE, CD27

Publications for Filariasis

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50PubMed
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Articles related to Filariasis:

(show top 50)    (show all 580)
idTitleAuthorsYear
1
Ongoing surveillance for lymphatic filariasis in togo: assessment of alternatives and nationwide reassessment of transmission status. (24189363)
2014
2
Therapeutic efficacy of poly (lactic-co-glycolic acid) nanoparticles encapsulated ivermectin (nano-ivermectin) against brugian filariasis in experimental rodent model. (24366812)
2013
3
Diagnosis of filariasis on cytology: a series of 24 cases. (24311546)
2013
4
Community-wide distribution of long-lasting insecticidal nets can halt transmission of lymphatic filariasis in southeastern Nigeria. (23939708)
2013
5
A rare case of ovarian and pelvic filariasis. (23820743)
2013
6
Insecticidal bed nets and filariasis transmission in Papua New Guinea. (23964936)
2013
7
Corallopyronin A - A promising antibiotic for treatment of filariasis. (24079981)
2013
8
Evaluation of gravid traps for the collection of Culex quinquefasciatus, a vector of lymphatic filariasis in Tanzania. (23222942)
2013
9
Drug targets for lymphatic filariasis: a bioinformatics approach. (24220073)
2013
10
Disability measurement for lymphatic filariasis: a review of generic tools used within morbidity management programs. (23029569)
2012
11
Maintaining effective mass drug administration for lymphatic filariasis through in-process monitoring in Sierra Leone. (23062561)
2012
12
Elimination of lymphatic filariasis: mass drug administration in endemic areas of (bidar district) karnataka-2008. (23293434)
2012
13
Predicting the current and future potential distributions of lymphatic filariasis in Africa using maximum entropy ecological niche modelling. (22359670)
2012
14
Surgical management of morbidity due to lymphatic filariasis: the usefulness of a standardized international clinical classification of hydroceles. (22543600)
2012
15
Progress toward elimination of lymphatic filariasis--Togo, 2000--2009. (21796097)
2011
16
Global Programme to eliminate lymphatic filariasis: progress report on mass drug administration, 2010. (21887884)
2011
17
History, epidemiology and control of filariasis. (22028595)
2011
18
Proliferative responses of Brugia malayi TPX-1 and its epitopic peptide(29-43) in an endemic population of human lymphatic filariasis. (21288496)
2011
19
Reduction in acute filariasis morbidity during a mass drug administration trial to eliminate lymphatic filariasis in Papua New Guinea. (21765964)
2011
20
Lymphatic filariasis: a method to identify subclinical lower limb change in PNG adolescents. (21811644)
2011
21
Role of community empowerment in the elimination of lymphatic filariasis in south India. (20562816)
2010
22
Lymphatic filariasis: Aspiration of adult gravid female worm from a soft tissue swelling. (21157572)
2010
23
Lymphatic filariasis and onchocerciasis. (20739055)
2010
24
Mapping of lymphatic filariasis: "to be (in English) or not to be". (21520639)
2010
25
Unresolving pericarditis: suspect filariasis in the tropics. (20061773)
2010
26
Decreased prevalence of lymphatic filariasis among subjects with type-1 diabetes. (21118945)
2010
27
Lymphatic filariasis in a rural community in Nigeria: a challenge ahead. (22416661)
2010
28
Filariasis of the breast, diagnosed by fine needle aspiration cytology. (19700906)
2009
29
The combined effect of the Lymphatic Filariasis Elimination Programme and the Schistosomiasis and Soil-transmitted Helminthiasis Control Programme on soil-transmitted helminthiasis in schoolchildren in Tanzania. (18771788)
2009
30
Case of thoracic and abdomino-pelvic lymphangiectasia caused by filariasis. (19996419)
2009
31
First report of filariasis in a non-endemic hill state of India. (19332954)
2009
32
Ecological meta-analysis of density-dependent processes in the transmission of lymphatic filariasis: survival of infected vectors. (19645292)
2009
33
Panorama of cytomorphological findings of filariasis in the contralateral breast, clinically mimicking a carcinoma in a known case: a case report. (18831013)
2008
34
Are coinfections of malaria and filariasis of any epidemiological significance? (18026992)
2008
35
Giant penoscrotal filariasis. (18626459)
2008
36
Effect of diethylcarbamazine on HIV load, CD4%, and CD4/CD8 ratio in HIV-infected adult Tanzanians with or without lymphatic filariasis: randomized double-blind and placebo-controlled cross-over trial. (17827369)
2007
37
Plasma vascular endothelial growth Factor-A (VEGF-A) and VEGF-A gene polymorphism are associated with hydrocele development in lymphatic filariasis. (17978056)
2007
38
Molecular xenomonitoring of lymphatic filariasis. (17978054)
2007
39
Evaluation of Og4C3 antigen ELISA as a tool for detection of bancroftian filariasis under lymphatic filariasis elimination programme. (18338684)
2007
40
Efficacy of a limb-care regime in preventing acute adenolymphangitis in patients with lymphoedema caused by bancroftian filariasis, in Colombo, Sri Lanka. (17716431)
2007
41
Delivery strategy of mass annual single dose DEC administration to eliminate lymphatic filariasis in the urban areas of Pondicherry, South India: 5 years of experience. (17718908)
2007
42
Ocular filariasis due to Wuchereria bancrofti presenting as panuveitis: a case report. (14533034)
2003
43
Bacterial symbionts (Wolbachia) of filarial nematodes: implications for the treatment and pathology of filariasis]. (11758285)
2001
44
Intervention research on onchocerciasis and lymphatic filariasis. (10946596)
2000
45
IL-5 is essential for vaccine-induced protection and for resolution of primary infection in murine filariasis. (11138639)
2000
46
Regulation of parasite antigen-driven immune responses by interleukin-10 (IL-10) and IL-12 in lymphatic filariasis. (9125556)
1997
47
Clinical and laboratory features of patients with loiasis (Loa loa filariasis) in the U.K. (8889997)
1996
48
Filariasis (Pelecitus sp.) in the cervical subcutaneous tissue of a pigeon with trichomoniasis. (7980294)
1994
49
Leprosy, filariasis and malaria as causes of secondary amyloidosis in the tropics. (286486)
1978
50
Elephantiasis scrotum (filariasis). (15411595)
1950

Genetic Variations for Filariasis

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Expression for genes affiliated with Filariasis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Filariasis

Search GEO for disease gene expression data for Filariasis.

Pathways for genes affiliated with Filariasis

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29KEGG, 52R&D Systems, 37NCBI BioSystems Database, 51QIAGEN, 4Cell Signaling Technology, 12EMD Millipore, 53Reactome, 59Tocris Bioscience, 55SinoBiological
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Pathways related to Filariasis according to GeneCards/GeneDecks:

(show all 24)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.3TLR2, TLR4
210.3IL13, IL5
310.2TLR4, TLR2, IL10
410.2IL5, IL10, IL13
510.2IL13, IL10, IL5
610.2IL13, IL10, IL5
710.2TLR4, TLR2, TLR1
8
Immune response Bacterial infections in normal airways
10.2TLR1, TLR2, TLR4
9
Hide members
10.2TLR4, TLR2, TLR1
1010.2TLR1, TLR2, TLR4
1110.2TLR4, TLR2, TLR1
12
Hide members
10.2TLR1, TLR2, TLR4
1310.2IL5, IL10, IGHE
1410.1TLR4, TLR2, TLR1, IL10
15
Hide members
10.1TLR4, TLR2, TLR1, IL10
16
Hide members
10.1IL10, TLR1, TLR2, TLR4
17
Hide members
10.1IL5, IL10, IL13, ICOS
18
Hide members
10.1TNFRSF18, TLR1, TLR2, TLR4
19
Hide members
10.0TLR4, TLR2, IL13, IL10, IL5
20
Hide members
10.0IL5, IL13, TLR1, TLR2, TLR4
21
Hide members
10.0TLR4, TLR2, TLR1, TNFRSF18, CD27
22
Hide members
9.9TLR4, TLR2, TLR1, ICOS, IGHE, IL5
23
Hide members
9.8TLR4, TLR2, TLR1, TNFRSF18, IL13, IL10
24
Hide members
9.8TLR4, TNFRSF18, PPP1R14B, CD27, IL13, IL10

Compounds for genes affiliated with Filariasis

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Sources:
44Novoseek, 28IUPHAR, 59Tocris Bioscience, 2BitterDB, 11DrugBank, 49PharmGKB, 24HMDB
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Compounds related to Filariasis according to GeneCards/GeneDecks:

(show top 50)    (show all 80)
idCompoundScoreTop Affiliating Genes
1amphotericin b4410.8IL13
2cyclosporin a44 28 5912.8IGHE
3cycloheximide4410.7TLR2
4rantes4410.7TLR2, TLR4
5hydrocortisone44 2 59 1113.7IGHE
6pam3csk45910.6TLR1, TLR2, TLR4
7pam2csk45910.6TLR2, TLR1, TLR4
8poly(i:c)5910.6TLR4, TLR2, TLR1
9glucuronoxylomannan4410.6TLR4, TLR2, IL10
10omalizumab44 1111.6IL5, IL13, IGHE
11gm-csf44 2811.6IL10
12resiquimod44 5911.6TLR1, TLR4, TLR2
13trimellitic anhydride4410.6IGHE, IL13
14ovomucoid4410.6IL5, IGHE, IL13
15glatiramer acetate44 1111.6IL10, IL5, IL13
16arabinogalactan4410.6TLR4, TLR2
17as 10159 4411.6IL13, IL10, IL5
18penicillin4410.6IL5, IL13, IGHE
19il-124410.6IL13, IL10, IL5
20flagellin44 2811.6TLR1, TLR2, TLR4
21p 2774410.6TLR2, IL10
22polyinosinic-polycytidylic acid4410.5TLR4, IL10, TLR2, IL5
23praziquantel44 1111.5IL5, IGHE, IL13, IL10
24methyltetrahydrophthalic anhydride4410.5IL13, IGHE
25montelukast44 49 28 1113.5IL13, IL5, IL10, IGHE
26lipoteichoic acid4410.5TLR4, TLR2, TLR1, IL10
27salbutamol44 49 28 11 2414.5IL10, IL5, IGHE, IL13
28ccl344 2811.5IL13, IL10, TLR4, TLR2
29peptidoglycan44 2811.5TLR1, TLR2, IL10, TLR4
30tarc4410.5IL13, IL5, IGHE, IL10
31polymyxin b4410.5IL10, TLR2, TLR4
32il 104410.5IL5, IL10, IL13, TLR4, TLR2
33imiquimod44 28 59 1113.5TLR4, TLR1, IL5, TLR2, IL10
34allergens4410.5IL5, IL13, TLR4, IGHE, IL10
35tacrolimus44 49 1112.4TLR2, TLR4, IL13, IL5, IL10
36budesonide44 49 1112.4IL5, IGHE, IL13
37prednisolone44 28 1112.4IL10, IL13, IGHE, IL5
38fluticasone propionate44 49 59 1113.4IL5, IGHE, IL13
39sb 20358044 5911.4IL5, TLR4, TLR2, IL13, IL10
40polysaccharide4410.3TLR4, TLR2, CHIT1, IL13, IGHE
41histamine44 28 2412.3IGHE, IL5, IL10, TLR2, IL13, TLR4
42vitamin d4410.3TLR4, TLR2, IL10, IGHE, IL5
43mannose4410.3TLR4, CHIT1, IL13, TLR2
44thyroxine44 2411.3IGHE, IL13, IL10, IL5
45pgd24410.3IGHE, IL13, IL5
46ionomycin4410.2IL13, IL5, IL10, TLR2
47poly(i-c)4410.1IL5, TLR4, TLR2
48diaminopimelic acid4410.0TLR4, TLR2
49dexamethasone44 49 28 1112.9TLR2, IGHE, IL13, IL10, IL5, TLR4
50vegf449.9IL13, IGHE, TLR2, TLR4, IL5, IL10

GO Terms for genes affiliated with Filariasis

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16Gene Ontology
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Cellular components related to Filariasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Toll-like receptor 1-Toll-like receptor 2 protein complexGO:03535410.0TLR2, TLR1
2integral to plasma membraneGO:0058879.9CD27, TNFRSF18, ICOS, TLR1, TLR2, TLR4
3external side of plasma membraneGO:0098979.8IL13, CD27, TNFRSF18, ICOS, TLR2, TLR4

Biological processes related to Filariasis according to GeneCards/GeneDecks:

(show all 20)
idNameGO IDScoreTop Affiliating Genes
1detection of triacyl bacterial lipopeptideGO:04249510.6TLR1, TLR2
2cellular response to triacyl bacterial lipopeptideGO:07172710.6TLR1, TLR2
3detection of diacyl bacterial lipopeptideGO:04249610.6TLR2, TLR1
4positive regulation of macrophage cytokine productionGO:06090710.6TLR2, TLR4
5cellular response to lipoteichoic acidGO:07122310.5TLR4, TLR2
6positive regulation of tumor necrosis factor biosynthetic processGO:04253510.5TLR1, TLR2, TLR4
7I-kappaB phosphorylationGO:00725210.5TLR4, TLR2, PRDX4
8regulation of cytokine secretionGO:05070710.5TLR4, TLR1
9positive regulation of MHC class II biosynthetic processGO:04534810.5TLR4, IL10
10positive regulation of B cell proliferationGO:03089010.5IL5, IL13, TLR4
11negative regulation of interleukin-17 productionGO:03270010.5TLR2, TLR4
12macrophage activationGO:04211610.4TLR1, TLR4
13positive regulation of nitric-oxide synthase biosynthetic processGO:05177010.4TLR2, TLR4
14inflammatory responseGO:00695410.3TLR2, TLR1, IL13, IL10, IL5
15MyD88-dependent toll-like receptor signaling pathwayGO:00275510.3TLR4, TLR2, TLR1
16positive regulation of chemokine productionGO:03272210.3TLR2, TLR4
17negative regulation of interleukin-12 productionGO:03269510.3IL10, TLR2
18T-helper 1 type immune responseGO:04208810.2TLR4, TLR1
19immune responseGO:00695510.1IL5, TLR4, TLR2, TLR1, ICOS, CHIT1
20negative regulation of growth of symbiont in hostGO:04413010.0IL10, TLR2

Molecular functions related to Filariasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1lipopolysaccharide receptor activityGO:00187510.3TLR2, TLR4
2transmembrane signaling receptor activityGO:0048889.8CD27, TLR1, TLR2, TLR4

Products for genes affiliated with Filariasis

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  • Antibodies
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Sources for Filariasis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet