Aliases & Classifications for Filariasis

MalaCards integrated aliases for Filariasis:

Name: Filariasis 12 72 51 41 14 69
Disease Due to Superfamily Filarioidea 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1080
ICD9CM 34 125.9
MeSH 41 D005368
NCIt 46 C34611
UMLS 69 C0016085

Summaries for Filariasis

Disease Ontology : 12 A parasitic helminthiasis infectious disease that involves parasitic infection of the lymphatics and subcutaneous tissue by nematodes of the superfamily Filarioidea.

MalaCards based summary : Filariasis, also known as disease due to superfamily filarioidea, is related to onchocerciasis and endomyocardial fibrosis. An important gene associated with Filariasis is IL5 (Interleukin 5), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Albendazole and Ivermectin have been mentioned in the context of this disorder. Affiliated tissues include testes, t cells and skin, and related phenotypes are immune system and digestive/alimentary

Wikipedia : 72 Filariasis is a parasitic disease caused by an infection with roundworms of the Filarioidea type. These... more...

Related Diseases for Filariasis

Diseases related to Filariasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 367)
# Related Disease Score Top Affiliating Genes
1 onchocerciasis 31.9 CCL5 IL2 IL5
2 endomyocardial fibrosis 30.2 IL10 TNF
3 parasitic helminthiasis infectious disease 30.1 IL10 IL5 TLR9 TNF
4 leprosy 3 29.5 IFNG IL10 IL2 TLR2 TNF
5 lichen planus 29.4 IFNG TLR9 TNF
6 schistosomiasis 29.3 ALB IFNG IL10 IL2 IL5 TNF
7 uveitis 29.3 CTLA4 IFNG IL10 TNF
8 prostatitis 29.3 IL10 IL6 TNF
9 arthritis 28.8 IFNG IL10 IL6 TNF
10 leishmaniasis 28.5 IFNG IL10 IL5 TLR2 TLR4 TLR9
11 hemorrhagic fever 28.4 ALB IFNG IL10 IL6 TNF
12 dengue hemorrhagic fever 28.4 ALB IFNG IL10 IL6 TNF
13 parasitic protozoa infectious disease 28.3 IFNG IL10 IL2 IL6 TLR9 TNF
14 chagas disease 28.2 IFNG IL10 IL2 IL6 TLR2 TLR4
15 rheumatoid arthritis 26.9 CCL5 CTLA4 IFNG IL10 IL2 IL6
16 trypanosomiasis 26.6 ALB CCL5 IFNG IL10 IL2 IL6
17 malaria 26.5 ALB CCL5 CHIT1 CTLA4 IFNG IL10
18 filarial elephantiasis 12.3
19 loiasis 11.9
20 dirofilariasis 11.4
21 elephantiasis 11.3
22 lymphedema 11.3
23 mansonelliasis 11.2
24 podoconiosis 11.2
25 setariasis 10.8
26 dipetalonemiasis 10.8
27 prosthetic joint infection 10.6 TLR2 TLR4
28 eosinophilic fasciitis 10.5 IFNG IL5
29 hyperlucent lung 10.4 IFNG IL10
30 punctate inner choroidopathy 10.4 IL10 TNF
31 berylliosis 10.4 IFNG IL2
32 oral tuberculosis 10.4 IL2 TNF
33 tropical endomyocardial fibrosis 10.4 IL10 TNF
34 variola major 10.4 IFNG IL2 TLR4
35 atopic keratoconjunctivitis 10.4 IFNG IL2 IL5
36 keratitis, hereditary 10.3 TLR2 TLR4 TLR9
37 pouchitis 10.3 IL10 TLR4
38 nasal cavity disease 10.3 IL10 IL5 TLR9
39 extrapulmonary tuberculosis 10.3 IFNG IL10 TLR2
40 urinary schistosomiasis 10.3 CTLA4 IFNG IL5
41 paranasal sinus disease 10.3 IFNG IL10 IL5
42 microscopic polyangiitis 10.3 IL10 TNF
43 multifocal choroiditis 10.3 IL10 TNF
44 spondylarthropathy 10.3 TLR4 TNF
45 tungiasis 10.3 IL10 TNF
46 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.3 CTLA4 IFNG IL10
47 ige responsiveness, atopic 10.3 IFNG IL10 IL5
48 herpes zoster 10.3 IFNG IL10 IL2
49 autoimmune disease of endocrine system 10.3 CTLA4 IFNG IL2
50 autoimmune lymphoproliferative syndrome 10.3 CTLA4 IL10 IL2

Graphical network of the top 20 diseases related to Filariasis:



Diseases related to Filariasis

Symptoms & Phenotypes for Filariasis

MGI Mouse Phenotypes related to Filariasis:

43 (show all 13)
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 10.31 IFNG IL10 IL2 IL5 IL6 TLR1
2 digestive/alimentary MP:0005381 10.29 ALB CTLA4 FLT4 IFNG IL10 IL2
3 hematopoietic system MP:0005397 10.29 IL6 TLR1 TLR2 TLR4 TLR6 TLR9
4 homeostasis/metabolism MP:0005376 10.23 ALB CTLA4 FLT4 IFNG IL10 IL2
5 cardiovascular system MP:0005385 10.18 CTLA4 FLT4 IFNG IL10 IL2 IL6
6 liver/biliary system MP:0005370 10.11 ALB CTLA4 FLT4 IFNG IL10 IL2
7 endocrine/exocrine gland MP:0005379 10.1 ALB CTLA4 IFNG IL10 IL2 IL6
8 mortality/aging MP:0010768 10.06 IL6 TLR2 TLR4 TLR9 TNF ALB
9 integument MP:0010771 10.01 IFNG IL10 IL6 TLR2 TLR4 TNF
10 muscle MP:0005369 9.86 IL10 IL6 TLR2 TLR4 TNF ALB
11 neoplasm MP:0002006 9.81 ALB IFNG IL10 IL2 IL5 IL6
12 reproductive system MP:0005389 9.61 FLT4 IFNG IL10 IL2 IL5 IL6
13 respiratory system MP:0005388 9.28 CTLA4 IFNG IL10 IL2 IL5 IL6

Drugs & Therapeutics for Filariasis

Drugs for Filariasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 49)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Albendazole Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 54965-21-8 2082
2
Ivermectin Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 70288-86-7 46936176 6474909
3
Diethylcarbamazine Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 1 90-89-1 3052
4
Doxycycline Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2 564-25-0 54671203
5
Praziquantel Approved, Investigational, Vet_approved Phase 4,Phase 1 55268-74-1 4891
6
Azithromycin Approved Phase 4,Phase 2 83905-01-5 53477736 447043 55185
7 Anthelmintics Phase 4,Phase 2,Phase 3,Phase 1
8 Anti-Infective Agents Phase 4,Phase 2,Phase 3,Phase 1
9 Antimitotic Agents Phase 4,Phase 2,Phase 3,Phase 1
10 Antiparasitic Agents Phase 4,Phase 2,Phase 3,Phase 1
11 Antiprotozoal Agents Phase 4,Phase 2,Phase 3,Phase 1
12 Lipoxygenase Inhibitors Phase 4,Phase 2,Phase 1
13 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2
14 Antimalarials Phase 4,Phase 3,Phase 2
15 Anticonvulsants Phase 4
16
Glycerol Approved, Investigational Phase 3 56-81-5 753
17
Petrolatum Approved, Investigational Phase 3 8009-03-8
18 Disinfectants Phase 3
19 Eusol Phase 3
20 Protective Agents Phase 3
21 Sodium hypochlorite Phase 3
22 Vitamins Phase 3
23 Milbemycin Phase 3,Phase 2
24
Rifampin Approved Phase 2 13292-46-1 5381226 5458213
25 Artemisinine Phase 2
26 Artemisinins Phase 2
27
Dihydroartemisinin Phase 2 71939-50-9 6918483
28
Piperaquine Phase 2 4085-31-8 5079497
29 Anti-Asthmatic Agents Phase 2
30 Antibodies Phase 2
31 Antibodies, Monoclonal Phase 2
32 Immunoglobulins Phase 2
33 Respiratory System Agents Phase 2
34 Antibiotics, Antitubercular Phase 2
35 Antitubercular Agents Phase 2
36 Cytochrome P-450 CYP3A Inducers Phase 2
37 Nucleic Acid Synthesis Inhibitors Phase 2
38 Imatinib Mesylate Phase 2 123596
39 Protein Kinase Inhibitors Phase 2
40
Romidepsin Approved, Investigational Phase 1 128517-07-7 5352062
41 Pharmaceutical Solutions Phase 1
42
Mebendazole Approved, Vet_approved 31431-39-7 4030
43
Piperazine Approved, Vet_approved 110-85-0 4837
44
Permethrin Approved, Investigational 52645-53-1 40326
45
Suramin Approved, Investigational 145-63-1 5361
46
Citric Acid Approved, Nutraceutical, Vet_approved 77-92-9 311
47 Piperazine citrate
48 Liver Extracts
49 Citrate Nutraceutical

Interventional clinical trials:

(show top 50) (show all 60)

# Name Status NCT ID Phase Drugs
1 Impact of Albendazole -Ivermectin on Wuchereria Bancrofti in Mali Completed NCT02784743 Phase 4 ''albendazole'' and ''ivermectin''
2 Post-treatment Effects of Ivermectin (IVM) or Diethylcarbamazine (DEC) in Loiasis Completed NCT01593722 Phase 4 Diethylcarbamazine;Ivermectin
3 Alternate Chemotherapy Regimens for the Clearance of W.Bancrofti Infection Completed NCT02005653 Phase 4 Diethylcarbamazine;Albendazole;Doxycycline
4 Twice Yearly Treatment for the Control of LF Recruiting NCT03036059 Phase 4 400 μg/kg Ivermectin + 400 mg Albendazole
5 Field Studies on the Feasibility of Interrupting the Transmission of Soil-transmitted Helminths (STH) Not yet recruiting NCT03014167 Phase 4 Albendazole
6 Effect of Concomitant Mansonella Perstans Microfilaremia on Immune Responses Following Single Dose Praziquantel in People With Schistosomiasis Not yet recruiting NCT02734186 Phase 4 Praziquantel
7 Ivermectin Treatment in Patients With Onchocerciasis-associated Epilepsy Not yet recruiting NCT03052998 Phase 4 Ivermectin
8 Safety Study of Combined Azithromycin, Ivermectin and Albendazole for Trachoma and Lymphatic Filariasis Withdrawn NCT01903057 Phase 4 azithromycin;ivermectin;albendazole;placebo
9 Repeat Ivermectin Mass Drug Administrations for Control of Malaria: a Pilot Safety and Efficacy Study Completed NCT02509481 Phase 2, Phase 3 Ivermectin;Albendazole
10 An RCT to Evaluate the Effect of a New Skin Care Regimen on SBF in Those With Podoconiosis Completed NCT02839772 Phase 3
11 IVM Alone vs ALB + IVM Against Onchocerciasis Completed NCT03238131 Phase 3 Ivermectin;Albendazole
12 Study Comparing Moxidectin And Ivermectin In Subjects With Onchocerca Volvulus Infection Completed NCT00790998 Phase 3 Moxidectin;Ivermectin
13 A 24 Month Study to Compare Efficacy of Doxycycline vs Placebo for Improving Filarial Lymphedema in Sri Lanka Recruiting NCT02929134 Phase 3 Doxycycline;Placebo
14 Efficacy of Ivermectin and Albendazole Against Onchocerciasis in the Volta Region, Ghana Active, not recruiting NCT02078024 Phase 3 IVM plus ALB;IVM
15 A 24 Month Study to Compare Efficacy of Doxycycline vs Placebo for Improving Filarial Lymphedema in India Not yet recruiting NCT02929121 Phase 3 Doxycycline;Placebo
16 A 24 Month Study, to Compare the Efficacy of Doxycycline vs. Placebo for Improving Filarial Lymphedema in Mali Not yet recruiting NCT02927496 Phase 3 Doxycycline;Placebo
17 Effect of Albendazole Dose on Treatment of Lymphatic Filariasis Completed NCT00511004 Phase 2 Albendazole;Diethylcarbamazine
18 Doxycycline to Treat Mansonella Perstans Infection in Patients With and Without Lymphatic Filariasis Completed NCT00340691 Phase 2 Doxycycline
19 Effect of Albendazole Dose on Clearance of Filarial Worms Completed NCT00339417 Phase 2 Albendazole;Ivermectin
20 Effect of Albendazole Dose on Clearance of Filarial Worms Completed NCT00375583 Phase 2 DEC/Albendazole
21 Efficacy and Safety of High-dose Ivermectin for Reducing Malaria Transmission: A Dose Finding Study Completed NCT02511353 Phase 2 ivermectin;placebo;dihydroartemisinin-piperaquine
22 Reslizumab to Prevent Post-treatment Eosinophilia in Loiasis Completed NCT01111305 Phase 2 Reslizumab;Diethylcarbamazine
23 Study Evaluating Orally Administered Moxidectin In Subjects With Onchocerca Volvulus Infection Completed NCT00300768 Phase 2 2 mg moxidectin;ivermectin 150 mcg/kg;4 mg moxidectin;8 mg moxidectin
24 Clinical Trial of Rifampin and Azithromycin for the Treatment of River Blindness Completed NCT00127504 Phase 2 Rifampin;Azithromycin
25 Concomitant Infections of Mansonella Perstans in Tuberculosis and Buruli Ulcer Disease Patients From Ghana Completed NCT02281643 Phase 2 Doxycycline
26 Eval 3-Drug Therapy Diethylcarbamize, Albendazole and Ivermectin That Could Accelerate LF Elimination Outside of Africa Active, not recruiting NCT01975441 Phase 2 Diethylcarbamazine;Albendazole;Ivermectin
27 Efficacy and Microfilaricidal Kinetics of Imatinib for the Treatment of Loa Loa Not yet recruiting NCT02644525 Phase 2 Imatinib Mesylate;Placebo
28 Pediatric Pharmacokinetics And Safety Study Of Moxidectin Withdrawn NCT01035619 Phase 2 moxidectin
29 First in Man Clinical Trial of Emodepside (BAY 44-4400) Completed NCT02661178 Phase 1 emodepside (BAY 44-4400);placebo
30 Safety, Tolerability and PK of Multiple-ascending Doses of Emodepside Recruiting NCT03383614 Phase 1 LSF emodepside (BAY 44-4400) oral solution (1mg/mL)
31 Relative Bioavailability Study of Emodepside IR-tablets and Solution Recruiting NCT03383523 Phase 1 Emodepside (BAY 44-4400)
32 Pharmacokinetics & Pharmacodynamics of Diethylcarbamazine (DEC)+ Albendazole (ALB) + Ivermectin (IVE) Active, not recruiting NCT02845713 Phase 1 Ivermectin, Diethylcarbamazine Albendazole (IDA)
33 Exhaled NO Testing in Filariasis Completed NCT01628497
34 Disability and Quality of Life in Patients With Lymphatic Filariasis in Rural Southern India Completed NCT01629771
35 Research for Elimination of Lymphatic Filariasis (ICIDR) Completed NCT00406627
36 Research for Elim of Filariasis Completed NCT00145223
37 Optimization of Mass Drug Administration With Existing Drug Regimens for Lymphatic Filariasis and Onchocerciasis Completed NCT01905423 Albendazole and diethylcarbamazine
38 Interaction Between HIV and Lymphatic Filariasis Completed NCT00295698 Diethylcarbamazine
39 Medical Implications of Coinfection With Malaria and Filariasis Parasites Completed NCT00471666
40 Safety of the Co-administration of Three Drugs for Trachoma and Lymphatic Filariasis Elimination Completed NCT01586169 triple co administration at once of the combination of Albendazole + ivermectin + azithromycin
41 Evaluation of Antibacterial Soap for Treatment of Lymphedema in a Filariasis-Endemic Area Completed NCT00139100 antimicrobial agent in soap
42 Changes in HIV Viral Load in Patients Undergoing Treatment for Filariasis Completed NCT00344279
43 Immune Response Regulation in People Infected Concurrently With Malarial and Filarial Parasites Completed NCT00341666
44 Promoting Consistent Shoe Use Among Children At High Risk for Podoconiosis Completed NCT01160523
45 Safety and Efficacy of Drug Combinations Against Triple Infections Completed NCT01050517 albendazole + ivermectin + praziquantel;albendazole + ivermectin + (1 week later) praziquantel
46 Community Directed Treatment of Soil-Transmitted Helminths Among Young Children in Zambia Completed NCT00349323
47 Study of Patients With Strongyloides Stercoralis Infection Completed NCT00001245
48 Epidemiology and Control of Mansonella Perstans Infection in Uganda Completed NCT00215280 ivermectin and albendazole
49 Prevalence Studies After Triple Drug Therapy for Lymphatic Filariasis Recruiting NCT03352206 2 drug dose - DA;3 drug dose - IDA
50 Optimization of Mass Drug Administration With Existing Drug Regimens for Lymphatic Filariasis and Onchocerciasis for Ivory Coast (DOLF-Ivory Coast) Recruiting NCT02032043 Annual versus Semiannual Albendazole plus Ivermectin MDA

Search NIH Clinical Center for Filariasis

Cochrane evidence based reviews: filariasis

Genetic Tests for Filariasis

Anatomical Context for Filariasis

MalaCards organs/tissues related to Filariasis:

38
Testes, T Cells, Skin, Liver, Breast, B Cells, Endothelial

Publications for Filariasis

Articles related to Filariasis:

(show top 50) (show all 749)
# Title Authors Year
1
<i>Carica papaya</i> (Papaya) latex: a new paradigm to combat against dengue and filariasis vectors<i>Aedes aegypti</i>and<i>Culex quinquefasciatus</i>(Diptera: Culicidae). ( 29430347 )
2018
2
Multiplex serology for impact evaluation of bed net distribution on burden of lymphatic filariasis and four species of human malaria in northern Mozambique. ( 29444078 )
2018
3
Prevalence of and risk factors for malaria, filariasis, and intestinal parasites as single infections or co-infections in different settlements of Gabon, Central Africa. ( 29378644 )
2018
4
Elimination of lymphatic filariasis in west African urban areas: is implementation of mass drug administration necessary? ( 29402636 )
2018
5
Corrigendum: Minocycline as a re-purposed anti-Wolbachia macrofilaricide: superiority compared with doxycycline regimens in a murine infection model of human lymphatic filariasis. ( 29308790 )
2018
6
Economic evaluations of lymphatic filariasis interventions: a systematic review and research needs. ( 29391042 )
2018
7
Molecular xenomonitoring for post-validation surveillance of lymphatic filariasis in Togo: no evidence for active transmission. ( 29361964 )
2018
8
Author Correction: Short-Course, High-Dose Rifampicin Achieves Wolbachia Depletion Predictive of Curative Outcomes in Preclinical Models of Lymphatic Filariasis and Onchocerciasis. ( 29348597 )
2018
9
Green synthesis of silver nanoparticles using Holarrhena antidysenterica (L.) Wall.bark extract and their larvicidal activity against dengue and filariasis vectors. ( 29250727 )
2018
10
Perceptions, knowledge, attitudes and practices for the prevention and control of lymphatic filariasis in Conakry, Republic of Guinea. ( 29224979 )
2018
11
Understanding heterogeneities in mosquito-bite exposure and infection distributions for the elimination of lymphatic filariasis. ( 29386362 )
2018
12
Geographical distribution and species identification of human filariasis and onchocerciasis in Bioko Island, Equatorial Guinea. ( 29289559 )
2018
13
Human infection with sub-periodic Brugia spp. in Gampaha District, Sri Lanka: a threat to filariasis elimination status? ( 29378620 )
2018
14
Community perspectives on persistent transmission of lymphatic filariasis in three hotspot districts in Ghana after 15 rounds of mass drug administration: a qualitative assessment. ( 29433461 )
2018
15
Island-Wide Surveillance of Gastrointestinal Protozoan Infections on Fiji by Expanding Lymphatic Filariasis Transmission Assessment Surveys as an Access Platform. ( 29405101 )
2018
16
Bancroftian filariasis associated with male sterility. ( 29330277 )
2018
17
How Frank Hawking, DM, and Table Salt, Helped Eliminate Lymphatic Filariasis From China. ( 28793168 )
2017
18
The National Programme to Eliminate Lymphatic Filariasis from Ethiopia. ( 28878429 )
2017
19
Pathological manifestations in lymphatic filariasis correlate with lack of inhibitory properties of IgG4 antibodies on IgE-activated granulocytes. ( 28742098 )
2017
20
Lymph Node Enlargement in Neck Filariasis as a Rare Cause: A Case Report. ( 29234183 )
2017
21
Filariasis Orchitis-Differential for Acute Scrotum Pathology. ( 28507911 )
2017
22
Integrated morbidity management for lymphatic filariasis and podoconiosis, Ethiopia. ( 28867846 )
2017
23
Criteria to Stop Mass Drug Administration for Lymphatic Filariasis Have Been Achieved Throughout Plateau and Nasarawa States, Nigeria. ( 28749759 )
2017
24
Twelve-month longitudinal parasitological assessment of lymphatic filariasis-positive individuals: impact of a biannual treatment with ivermectin and albendazole. ( 28891597 )
2017
25
Potential Value of Triple Drug Therapy with Ivermectin, Diethylcarbamazine, and Albendazole (IDA) to Accelerate Elimination of Lymphatic Filariasis and Onchocerciasis in Africa. ( 28056015 )
2017
26
For as long as necessary: examining 30 years of Merck & Co., Inc.'s focus on achieving elimination of onchocerciasis and lymphatic filariasis. ( 29186497 )
2017
27
Screening and evaluation of lymphatic filariasis in immigrants from endemic countries residing in a focus where it is considered eliminated in the Southern Region of Brazil: A risk of reemergence? ( 28823910 )
2017
28
Subconjunctival ocular filariasis -Case report. ( 29450376 )
2017
29
Prevalence and risk factors associated with lymphatic filariasis in American Samoa after mass drug administration. ( 28794687 )
2017
30
The Current Status of Molecular Xenomonitoring for Lymphatic Filariasis and Onchocerciasis. ( 28756911 )
2017
31
Efficacy of the volatile oil from water celery (Helosciadium nodiflorum, Apiaceae) against the filariasis vector Culex quinquefasciatus, the housefly Musca domestica, and the African cotton leafworm Spodoptera littoralis. ( 28862791 )
2017
32
Community-based field implementation scenarios of a short message service reporting tool for lymphatic filariasis case estimates in Africa and Asia. ( 28828375 )
2017
33
Short-Course, High-Dose Rifampicin Achieves Wolbachia Depletion Predictive of Curative Outcomes in Preclinical Models of Lymphatic Filariasis and Onchocerciasis. ( 28303006 )
2017
34
Seroprevalence of lymphatic filariasis among migrant workers in Peninsular Malaysia. ( 29206992 )
2017
35
Efficacy and tolerability of treatment with single doses of diethylcarbamazine (DEC) and DEC plus albendazole (ABZ) for three consecutive years in lymphatic filariasis: a field study in India. ( 28785847 )
2017
36
Follow-up Study of Patients Previously Diagnosed with Lymphatic Filariasis in Korea. ( 29354401 )
2017
37
Improving the efficacy of a prophylactic vaccine formulation against lymphatic filariasis. ( 28828575 )
2017
38
Detecting and confirming residual hotspots of lymphatic filariasis transmission in American Samoa 8 years after stopping mass drug administration. ( 28922418 )
2017
39
Imported Asymptomatic Bancroftian Filariasis Discovered from a Plasmodium vivax Infected Patient: A Case Report from Singapore. ( 28804661 )
2017
40
Loa loa vectors Chrysops spp.: perspectives on research, distribution, bionomics, and implications for elimination of lymphatic filariasis and onchocerciasis. ( 28381279 )
2017
41
Assessing endgame strategies for the elimination of lymphatic filariasis: A model-based evaluation of the impact of DEC-medicated salt. ( 28785097 )
2017
42
Generation and selection of naA^ve Fab library for parasitic antigen: Anti-BmSXP antibodies for lymphatic filariasis. ( 28833498 )
2017
43
Bilateral breast filariasis mimicking inflammatory breast carcinoma. ( 29184008 )
2017
44
Continental-scale, data-driven predictive assessment of eliminating the vector-borne disease, lymphatic filariasis, in sub-Saharan Africa by 2020. ( 28950862 )
2017
45
How much will it cost to eradicate lymphatic filariasis? An analysis of the financial and economic costs of intensified efforts against lymphatic filariasis. ( 28949987 )
2017
46
Prevalence of Lymphatic Filariasis and Treatment Effectiveness of Albendazole/ Ivermectin in Individuals with HIV Co-infection in Southwest-Tanzania. ( 27070786 )
2016
47
Current Epidemiological Assessment of Bancroftian Filariasis in Tanga Region, Northeastern Tanzania. ( 28050171 )
2016
48
Breast Filariasis Diagnosed by Real Time Sonographic Imaging: A Case Report. ( 27110331 )
2016
49
On the Thermal Stability of the Diethylcarbamazine-Fortified TableA Salt Used in the Control of Lymphatic Filariasis. ( 27397435 )
2016
50
Bilateral Testicular Metastases and Filariasis in Prostatic Adenocarcinoma. ( 28017535 )
2016

Variations for Filariasis

Expression for Filariasis

Search GEO for disease gene expression data for Filariasis.

Pathways for Filariasis

Pathways related to Filariasis according to GeneCards Suite gene sharing:

(show top 50) (show all 72)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.06 CCL5 CHIT1 CTLA4 IFNG IL10 IL2
2
Show member pathways
13.7 CCL5 FLT4 IFNG IL10 IL2 IL5
3
Show member pathways
13.57 CCL5 FLT4 IFNG IL10 IL2 IL5
4
Show member pathways
13.46 CCL5 FLT4 IL10 IL2 IL5 IL6
5
Show member pathways
13.39 CCL5 IFNG IL10 IL2 IL5 IL6
6
Show member pathways
13.34 CCL5 FLT4 IL10 IL2 IL5 IL6
7
Show member pathways
13.3 IFNG IL2 TLR1 TLR2 TLR4 TLR6
8
Show member pathways
13.07 CCL5 IL6 TLR1 TLR2 TLR4 TLR6
9
Show member pathways
13.02 FLT4 IL2 IL6 TLR2 TLR4 TNF
10
Show member pathways
12.96 CTLA4 IFNG IL10 IL2 IL5 IL6
11
Show member pathways
12.91 CCL5 IFNG IL2 IL6 TLR2 TLR4
12 12.86 FLT4 IFNG IL2 IL5 IL6
13
Show member pathways
12.8 FLT4 IL2 IL6 TLR1 TLR2 TLR4
14
Show member pathways
12.73 FLT4 TLR1 TLR2 TLR4 TLR6 TLR9
15
Show member pathways
12.71 IFNG IL10 IL2 IL5 IL6 TLR2
16
Show member pathways
12.65 IFNG IL10 IL2 IL6 TNF
17 12.58 CCL5 CTLA4 IFNG IL10 IL2 TLR1
18
Show member pathways
12.55 CTLA4 IFNG IL10 IL2 IL5 IL6
19
Show member pathways
12.49 TLR1 TLR2 TLR4 TLR6
20
Show member pathways
12.48 IFNG IL10 IL2 IL5 IL6
21
Show member pathways
12.46 ALB CCL5 IFNG IL2 IL6 TNF
22
Show member pathways
12.44 IFNG IL5 IL6 TLR2 TNF
23
Show member pathways
12.39 CCL5 IFNG IL10 IL2 IL6 TLR1
24
Show member pathways
12.38 IL6 TLR1 TLR2 TLR4 TLR6 TLR9
25
Show member pathways
12.37 IFNG IL10 TLR2 TLR4 TNF
26
Show member pathways
12.32 IFNG IL6 TLR4 TNF
27
Show member pathways
12.29 IFNG IL10 IL2 IL5 IL6 TNF
28
Show member pathways
12.28 IFNG IL6 TLR1 TLR2 TLR4 TLR6
29 12.25 IFNG IL6 TLR1 TLR2 TLR4 TLR6
30 12.19 TLR1 TLR2 TLR4 TLR6 TLR9
31 12.16 IFNG IL10 IL6 TLR1 TLR2 TLR4
32 12.15 IFNG IL2 IL6 TLR4 TNF
33
Show member pathways
12.15 IL2 IL5 TLR1 TLR2 TLR4 TLR6
34 12.13 IFNG IL10 IL2 IL5 IL6 TNF
35 12.04 IFNG IL10 IL6 TLR2 TLR4 TNF
36
Show member pathways
12 IFNG IL6 TLR1 TLR2 TLR4 TLR6
37 11.98 CCL5 CTLA4 IFNG IL6 TLR2 TLR4
38 11.96 CCL5 IL6 TNF
39 11.96 TLR1 TLR2 TLR4 TLR6 TLR9
40 11.93 IFNG IL10 IL2 IL6
41 11.93 IFNG IL2 IL5 IL6
42 11.93 IFNG IL10 IL2 IL5 TNF
43 11.92 IFNG IL6 TLR4
44 11.91 IL5 IL6 TNF
45
Show member pathways
11.9 CTLA4 IFNG IL2 IL5 TNF
46 11.89 IL10 IL6 TLR4 TNF
47 11.89 IFNG IL10 IL2 IL6 TLR9 TNF
48 11.85 IFNG IL6 TLR4
49 11.8 CCL5 IL5 IL6 TNF
50
Show member pathways
11.8 IFNG IL2 IL6 TNF

GO Terms for Filariasis

Cellular components related to Filariasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.91 CTLA4 FLT4 TLR1 TLR2 TLR4 TLR6
2 extracellular region GO:0005576 9.7 ALB CCL5 CHIT1 FLT4 IFNG IL10
3 membrane raft GO:0045121 9.56 TLR1 TLR2 TLR6 TNF
4 phagocytic vesicle membrane GO:0030670 9.5 TLR1 TLR2 TLR6
5 extracellular space GO:0005615 9.32 ALB CCL5 CHIT1 IFNG IL10 IL2
6 Toll-like receptor 1-Toll-like receptor 2 protein complex GO:0035354 9.16 TLR1 TLR2

Biological processes related to Filariasis according to GeneCards Suite gene sharing:

(show top 50) (show all 93)
# Name GO ID Score Top Affiliating Genes
1 cellular response to lipopolysaccharide GO:0071222 9.98 IL10 IL6 TLR4 TNF
2 positive regulation of DNA binding transcription factor activity GO:0051091 9.96 IL10 IL5 IL6 TNF
3 response to virus GO:0009615 9.95 CCL5 IFNG TNF
4 defense response to Gram-positive bacterium GO:0050830 9.94 IL6 TLR2 TNF
5 positive regulation of MAPK cascade GO:0043410 9.94 FLT4 IL6 TLR9
6 defense response to Gram-negative bacterium GO:0050829 9.93 IL6 TLR4 TLR9
7 positive regulation of JNK cascade GO:0046330 9.93 FLT4 TLR4 TLR9 TNF
8 regulation of insulin secretion GO:0050796 9.92 CCL5 IFNG TNF
9 positive regulation of inflammatory response GO:0050729 9.92 IL2 TLR2 TLR4 TLR9
10 response to glucocorticoid GO:0051384 9.91 IL10 IL6 TNF
11 positive regulation of T cell proliferation GO:0042102 9.91 CCL5 IL2 IL6
12 positive regulation of smooth muscle cell proliferation GO:0048661 9.91 CCL5 IL6 TNF
13 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.91 CCL5 IFNG IL2 IL6
14 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.91 IL6 TLR2 TLR4 TLR6 TLR9 TNF
15 humoral immune response GO:0006959 9.9 IFNG IL6 TNF
16 positive regulation of tumor necrosis factor production GO:0032760 9.89 TLR2 TLR4 TLR9
17 positive regulation of interferon-gamma production GO:0032729 9.89 IL2 TLR4 TNF
18 positive regulation of nitric oxide biosynthetic process GO:0045429 9.88 IFNG TLR4 TLR6 TNF
19 positive regulation of JUN kinase activity GO:0043507 9.87 TLR6 TLR9 TNF
20 positive regulation of B cell proliferation GO:0030890 9.87 IL2 IL5 TLR4 TLR9
21 lipopolysaccharide-mediated signaling pathway GO:0031663 9.85 CCL5 TLR2 TLR4 TNF
22 positive regulation of interferon-beta production GO:0032728 9.83 TLR2 TLR4 TLR9
23 positive regulation of interleukin-10 production GO:0032733 9.83 TLR2 TLR4 TLR9
24 positive regulation of JAK-STAT cascade GO:0046427 9.82 CCL5 IL5 IL6
25 positive regulation of macrophage activation GO:0043032 9.82 IL10 TLR4 TLR6
26 cell activation GO:0001775 9.81 TLR1 TLR2 TLR6
27 positive regulation of interleukin-8 production GO:0032757 9.81 TLR2 TLR4 TLR9 TNF
28 regulation of regulatory T cell differentiation GO:0045589 9.8 CTLA4 IFNG IL2
29 negative regulation of interleukin-6 production GO:0032715 9.8 IL10 TLR4 TLR9 TNF
30 positive regulation of interleukin-6 production GO:0032755 9.8 IL6 TLR2 TLR4 TLR9 TNF
31 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.79 TLR2 TLR4 TLR9
32 response to molecule of bacterial origin GO:0002237 9.78 IL10 TLR2 TLR9
33 positive regulation of interleukin-12 production GO:0032735 9.78 IFNG TLR2 TLR4 TLR9
34 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.77 IFNG TNF
35 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.77 TLR4 TLR6
36 microglial cell activation GO:0001774 9.77 TLR2 TLR6
37 negative regulation of growth of symbiont in host GO:0044130 9.77 IL10 TNF
38 positive regulation of interleukin-8 secretion GO:2000484 9.77 TLR1 TLR2
39 I-kappaB phosphorylation GO:0007252 9.77 TLR2 TLR4 TLR9
40 positive regulation of immunoglobulin secretion GO:0051024 9.77 IL2 IL5 IL6
41 toll-like receptor signaling pathway GO:0002224 9.77 TLR1 TLR2 TLR4 TLR6 TLR9
42 positive regulation of reactive oxygen species biosynthetic process GO:1903428 9.76 TLR4 TLR6
43 positive regulation of podosome assembly GO:0071803 9.76 IL5 TNF
44 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.76 IL10 TNF
45 T-helper 1 type immune response GO:0042088 9.76 TLR4 TLR6
46 positive regulation of tumor necrosis factor biosynthetic process GO:0042535 9.76 TLR1 TLR4
47 negative regulation of interleukin-17 production GO:0032700 9.76 IFNG TLR4
48 positive regulation of NF-kappaB import into nucleus GO:0042346 9.76 TLR2 TLR4 TLR9 TNF
49 cellular response to lipoteichoic acid GO:0071223 9.75 TLR2 TLR4
50 macrophage activation GO:0042116 9.75 TLR1 TLR4

Molecular functions related to Filariasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transmembrane signaling receptor activity GO:0004888 9.71 TLR1 TLR4 TLR6 TLR9
2 receptor activity GO:0004872 9.67 TLR1 TLR2 TLR4 TLR6
3 growth factor activity GO:0008083 9.56 IL10 IL2 IL5 IL6
4 lipopolysaccharide receptor activity GO:0001875 9.32 TLR2 TLR4
5 cytokine activity GO:0005125 9.17 CCL5 IFNG IL10 IL2 IL5 IL6
6 Toll-like receptor 2 binding GO:0035663 9.16 TLR1 TLR6
7 lipopeptide binding GO:0071723 9.13 TLR1 TLR2 TLR6

Sources for Filariasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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