Aliases & Classifications for Filariasis

MalaCards integrated aliases for Filariasis:

Name: Filariasis 12 52 42 14 69
Disease Due to Superfamily Filarioidea 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1080
ICD9CM 35 125.9
MeSH 42 D005368
NCIt 47 C34611
UMLS 69 C0016085

Summaries for Filariasis

Disease Ontology : 12 A parasitic helminthiasis infectious disease that involves parasitic infection of the lymphatics and subcutaneous tissue by nematodes of the superfamily Filarioidea.

MalaCards based summary : Filariasis, also known as disease due to superfamily filarioidea, is related to loiasis and scabies. An important gene associated with Filariasis is IL5 (Interleukin 5), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Albendazole and Ivermectin have been mentioned in the context of this disorder. Affiliated tissues include testes, breast and t cells, and related phenotypes are immune system and digestive/alimentary

Wikipedia : 72 Filariasis is a parasitic disease caused by an infection with roundworms of the Filarioidea type. These... more...

Related Diseases for Filariasis

Diseases related to Filariasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 357)
id Related Disease Score Top Affiliating Genes
1 loiasis 33.4 IFNG IL10 IL5
2 scabies 27.9 ALB IFNG IL10 IL6 TLR2 TNF
3 lymphoma 26.3 ALB CTLA4 IFNG IL10 IL2 IL5
4 rheumatoid arthritis 26.0 CCL5 CTLA4 IFNG IL10 IL2 IL6
5 malaria 25.0 ALB CCL5 CHIT1 CTLA4 IFNG IL10
6 filarial elephantiasis 11.9
7 dirofilariasis 11.3
8 elephantiasis 11.2
9 lymphedema 11.2
10 onchocerciasis 11.2
11 mansonelliasis 11.1
12 podoconiosis 11.1
13 prothrombin thrombophilia 10.8 TLR2 TLR4
14 setariasis 10.7
15 dipetalonemiasis 10.7
16 gastroschisis 10.7 IFNG IL5
17 eye accommodation disease 10.6 IFNG IL10
18 pure autonomic failure 10.6 IL10 TNF
19 scirrhous adenocarcinoma 10.5 IL2 TNF
20 bulbospinal polio 10.5 IFNG IL2 TLR4
21 x-linked intellectual disability, van esch type 10.5 IFNG IL2 IL5
22 acute ackee fruit intoxication 10.5 IL10 TNF
23 graft-versus-host disease, protection against 10.5 IFNG IL10 IL2
24 eyelid neoplasm 10.5 IL10 IL5 TLR9
25 askin's tumor 10.5 IFNG IL10 TLR2
26 acute gonococcal prostatitis 10.5 CTLA4 IFNG IL5
27 anthracosilicosis 10.5 IFNG IL2
28 combined cellular and humoral immune defects with granulomas 10.5 CTLA4 IFNG IL10
29 sezary's disease 10.4 IFNG IL10 IL2
30 cd3zeta deficiency 10.4 CTLA4 IFNG IL2
31 multiple familial trichoepithelioma 10.4 IL10 TNF
32 rickettsialpox 10.4 TLR2 TLR4 TNF
33 aseptic meningitis 10.4 TLR2 TLR4 TNF
34 basidiobolomycosis 10.4 IL10 TNF
35 spondylocostal dysostosis 4 10.4 TLR4 TNF
36 lagophthalmos 10.4 IL10 TNF
37 orofaciodigital syndrome iv 10.4 CTLA4 IL10 IL2
38 cloacogenic carcinoma 10.4 CTLA4 IFNG IL2
39 common peroneal nerve lesion 10.4 IL5 IL6
40 congenital insensitivity to pain with hyperhidrosis 10.4 IL10 TLR4
41 nasopharyngitis 10.4 TLR2 TLR4 TNF
42 glioblastoma multiforme 10.4 IL10 IL5 TNF
43 combined oxidative phosphorylation deficiency 8 10.3 IFNG IL10 IL5
44 endogenous depression 10.3 IL2 TLR2 TNF
45 brown-vialetto-van laere syndrome 10.3 CTLA4 IL2 TLR9
46 type 1 papillary adenoma of the kidney 10.3 IL10 TNF
47 pericardium disease 10.3 IL10 TLR2 TNF
48 sternal cleft 10.3 IFNG TNF
49 signet ring cell adenocarcinoma 10.3 FLT4 IL5 TNF
50 queensland tick typhus 10.3 IL5 IL6 TLR2

Graphical network of the top 20 diseases related to Filariasis:



Diseases related to Filariasis

Symptoms & Phenotypes for Filariasis

MGI Mouse Phenotypes related to Filariasis:

44 (show all 13)
id Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 10.31 FLT4 IFNG IL10 IL2 IL5 IL6
2 digestive/alimentary MP:0005381 10.29 ALB CTLA4 FLT4 IFNG IL10 IL2
3 hematopoietic system MP:0005397 10.29 IL6 TLR1 TLR2 TLR4 TLR6 TLR9
4 homeostasis/metabolism MP:0005376 10.23 ALB CTLA4 FLT4 IFNG IL10 IL2
5 cardiovascular system MP:0005385 10.18 CTLA4 FLT4 IFNG IL10 IL2 IL6
6 liver/biliary system MP:0005370 10.11 ALB CTLA4 FLT4 IFNG IL10 IL2
7 endocrine/exocrine gland MP:0005379 10.1 ALB CTLA4 IFNG IL10 IL2 IL6
8 mortality/aging MP:0010768 10.06 IL2 IL6 TLR2 TLR4 TLR9 TNF
9 integument MP:0010771 10.01 IFNG IL10 IL6 TLR2 TLR4 TNF
10 muscle MP:0005369 9.86 IL10 IL6 TLR2 TLR4 TNF ALB
11 neoplasm MP:0002006 9.81 ALB IFNG IL10 IL2 IL5 IL6
12 reproductive system MP:0005389 9.61 FLT4 IFNG IL10 IL2 IL5 IL6
13 respiratory system MP:0005388 9.28 CTLA4 IFNG IL10 IL2 IL5 IL6

Drugs & Therapeutics for Filariasis

Drugs for Filariasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 46)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Albendazole Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 54965-21-8 2082
2
Ivermectin Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 70288-86-7 6474909 46936176
3
Diethylcarbamazine Approved, Vet_approved Phase 4,Phase 2,Phase 1 90-89-1 3052
4
Doxycycline Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2 564-25-0 54671203
5
Praziquantel Approved, Vet_approved Phase 4 55268-74-1 4891
6
Azithromycin Approved Phase 4,Phase 2 83905-01-5 55185 53477736 447043
7 Anthelmintics Phase 4,Phase 2,Phase 3,Phase 1
8 Anti-Infective Agents Phase 4,Phase 2,Phase 3,Phase 1
9 Antimitotic Agents Phase 4,Phase 2,Phase 3,Phase 1
10 Antiparasitic Agents Phase 4,Phase 2,Phase 3,Phase 1
11 Antiprotozoal Agents Phase 4,Phase 2,Phase 3,Phase 1
12 Lipoxygenase Inhibitors Phase 4,Phase 2,Phase 1
13 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2
14 Antimalarials Phase 4,Phase 3,Phase 2
15 Anticonvulsants Phase 4
16
Glycerol Approved, Investigational Phase 3 56-81-5 753
17
Petrolatum Approved Phase 3 8009-03-8
18 Disinfectants Phase 3
19 Eusol Phase 3
20 Protective Agents Phase 3
21 Sodium hypochlorite Phase 3
22 Vitamins Phase 3
23 Milbemycin Phase 3,Phase 2
24
Rifampin Approved Phase 2 13292-46-1 5458213 5381226
25 Artemisinine Phase 2
26 Artemisinins Phase 2
27
Dihydroartemisinin Phase 2 71939-50-9 6918483
28
Piperaquine Phase 2 4085-31-8 5079497
29 Antibiotics, Antitubercular Phase 2
30 Antitubercular Agents Phase 2
31 Cytochrome P-450 CYP3A Inducers Phase 2
32 Nucleic Acid Synthesis Inhibitors Phase 2
33 Antibodies Phase 2
34 Antibodies, Monoclonal Phase 2
35 Immunoglobulins Phase 2
36 Imatinib Mesylate Phase 2 123596
37 Protein Kinase Inhibitors Phase 2
38
Romidepsin Approved, Investigational Phase 1 128517-07-7 5352062
39
Permethrin Approved, Investigational 52645-53-1 40326
40
Suramin Approved 145-63-1 5361
41
Mebendazole Approved, Vet_approved 31431-39-7 4030
42
Piperazine Approved, Vet_approved 110-85-0 4837
43 Liver Extracts
44 Piperazine citrate
45 Citrate Nutraceutical
46
Citric Acid Nutraceutical, Vet_approved 77-92-9 311

Interventional clinical trials:

(show top 50) (show all 57)

id Name Status NCT ID Phase Drugs
1 Impact of Albendazole -Ivermectin on Wuchereria Bancrofti in Mali Completed NCT02784743 Phase 4 ''albendazole'' and ''ivermectin''
2 Post-treatment Effects of Ivermectin (IVM) or Diethylcarbamazine (DEC) in Loiasis Completed NCT01593722 Phase 4 Diethylcarbamazine;Ivermectin
3 Alternate Chemotherapy Regimens for the Clearance of W.Bancrofti Infection Completed NCT02005653 Phase 4 Diethylcarbamazine;Albendazole;Doxycycline
4 Twice Yearly Treatment for the Control of LF Recruiting NCT03036059 Phase 4 400 μg/kg Ivermectin + 400 mg Albendazole
5 Field Studies on the Feasibility of Interrupting the Transmission of Soil-transmitted Helminths (STH) Not yet recruiting NCT03014167 Phase 4 Albendazole
6 Effect of Concomitant Mansonella Perstans Microfilaremia on Immune Responses Following Single Dose Praziquantel in People With Schistosomiasis Not yet recruiting NCT02734186 Phase 4 Praziquantel
7 Ivermectin Treatment in Patients With Onchocerciasis-associated Epilepsy Not yet recruiting NCT03052998 Phase 4 Ivermectin
8 Safety Study of Combined Azithromycin, Ivermectin and Albendazole for Trachoma and Lymphatic Filariasis Withdrawn NCT01903057 Phase 4 azithromycin;ivermectin;albendazole;placebo
9 Repeat Ivermectin Mass Drug Administrations for Control of Malaria: a Pilot Safety and Efficacy Study Completed NCT02509481 Phase 2, Phase 3 Ivermectin;Albendazole
10 An RCT to Evaluate the Effect of a New Skin Care Regimen on SBF in Those With Podoconiosis Completed NCT02839772 Phase 3
11 IVM Alone vs ALB + IVM Against Onchocerciasis Completed NCT03238131 Phase 3 Ivermectin;Albendazole
12 Study Comparing Moxidectin And Ivermectin In Subjects With Onchocerca Volvulus Infection Completed NCT00790998 Phase 3 Moxidectin;Ivermectin
13 Efficacy of Ivermectin and Albendazole Against Onchocerciasis in the Volta Region, Ghana Active, not recruiting NCT02078024 Phase 3 IVM plus ALB;IVM
14 A 24 Month Study to Compare Efficacy of Doxycycline vs Placebo for Improving Filarial Lymphedema in Sri Lanka Not yet recruiting NCT02929134 Phase 3 Doxycycline;Placebo
15 A 24 Month Study to Compare Efficacy of Doxycycline vs Placebo for Improving Filarial Lymphedema in India Not yet recruiting NCT02929121 Phase 3 Doxycycline;Placebo
16 A 24 Month Study, to Compare the Efficacy of Doxycycline vs. Placebo for Improving Filarial Lymphedema in Mali Not yet recruiting NCT02927496 Phase 3 Doxycycline;Placebo
17 Effect of Albendazole Dose on Treatment of Lymphatic Filariasis Completed NCT00511004 Phase 2 Albendazole;Diethylcarbamazine
18 Doxycycline to Treat Mansonella Perstans Infection in Patients With and Without Lymphatic Filariasis Completed NCT00340691 Phase 2 Doxycycline
19 Effect of Albendazole Dose on Clearance of Filarial Worms Completed NCT00339417 Phase 2 Albendazole;Ivermectin
20 Effect of Albendazole Dose on Clearance of Filarial Worms Completed NCT00375583 Phase 2 DEC/Albendazole
21 Efficacy and Safety of High-dose Ivermectin for Reducing Malaria Transmission: A Dose Finding Study Completed NCT02511353 Phase 2 ivermectin;placebo;dihydroartemisinin-piperaquine
22 Study Evaluating Orally Administered Moxidectin In Subjects With Onchocerca Volvulus Infection Completed NCT00300768 Phase 2 2 mg moxidectin;ivermectin 150 mcg/kg;4 mg moxidectin;8 mg moxidectin
23 Clinical Trial of Rifampin and Azithromycin for the Treatment of River Blindness Completed NCT00127504 Phase 2 Rifampin;Azithromycin
24 Concomitant Infections of Mansonella Perstans in Tuberculosis and Buruli Ulcer Disease Patients From Ghana Completed NCT02281643 Phase 2 Doxycycline
25 Eval 3-Drug Therapy Diethylcarbamize, Albendazole and Ivermectin That Could Accelerate LF Elimination Outside of Africa Active, not recruiting NCT01975441 Phase 2 Diethylcarbamazine;Albendazole;Ivermectin
26 Reslizumab to Prevent Post-treatment Eosinophilia in Loiasis Active, not recruiting NCT01111305 Phase 2 Reslizumab;Diethylcarbamazine
27 Efficacy and Microfilaricidal Kinetics of Imatinib for the Treatment of Loa Loa Not yet recruiting NCT02644525 Phase 2 Imatinib Mesylate;Placebo
28 Pediatric Pharmacokinetics And Safety Study Of Moxidectin Withdrawn NCT01035619 Phase 2 moxidectin
29 First in Man Clinical Trial of Emodepside (BAY 44-4400) Completed NCT02661178 Phase 1 emodepside (BAY 44-4400);placebo
30 Pharmacokinetics & Pharmacodynamics of Diethylcarbamazine (DEC)+ Albendazole (ALB) + Ivermectin (IVE) Active, not recruiting NCT02845713 Phase 1 Ivermectin, Diethylcarbamazine Albendazole (IDA)
31 Exhaled NO Testing in Filariasis Completed NCT01628497
32 Disability and Quality of Life in Patients With Lymphatic Filariasis in Rural Southern India Completed NCT01629771
33 Research for Elim of Filariasis Completed NCT00145223
34 Research for Elimination of Lymphatic Filariasis (ICIDR) Completed NCT00406627
35 Interaction Between HIV and Lymphatic Filariasis Completed NCT00295698 Diethylcarbamazine
36 Medical Implications of Coinfection With Malaria and Filariasis Parasites Completed NCT00471666
37 Safety of the Co-administration of Three Drugs for Trachoma and Lymphatic Filariasis Elimination Completed NCT01586169 triple co administration at once of the combination of Albendazole + ivermectin + azithromycin
38 Evaluation of Antibacterial Soap for Treatment of Lymphedema in a Filariasis-Endemic Area Completed NCT00139100 antimicrobial agent in soap
39 Changes in HIV Viral Load in Patients Undergoing Treatment for Filariasis Completed NCT00344279
40 Immune Response Regulation in People Infected Concurrently With Malarial and Filarial Parasites Completed NCT00341666
41 Promoting Consistent Shoe Use Among Children At High Risk for Podoconiosis Completed NCT01160523
42 Safety and Efficacy of Drug Combinations Against Triple Infections Completed NCT01050517 albendazole + ivermectin + praziquantel;albendazole + ivermectin + (1 week later) praziquantel
43 Community Directed Treatment of Soil-Transmitted Helminths Among Young Children in Zambia Completed NCT00349323
44 Study of Patients With Strongyloides Stercoralis Infection Completed NCT00001245
45 Epidemiology and Control of Mansonella Perstans Infection in Uganda Completed NCT00215280 ivermectin and albendazole
46 Death to Onchocerciasis and Lymphatic Filariasis (DOLF) Triple Drug Therapy for Lymphatic Filariasis Recruiting NCT02899936 3 drug dose - IDA;2 drug dose - DA
47 Optimization of Mass Drug Administration With Existing Drug Regimens for Lymphatic Filariasis and Onchocerciasis for Ivory Coast (DOLF-Ivory Coast) Recruiting NCT02032043 Annual versus Semiannual Albendazole plus Ivermectin MDA
48 Fiji Integrated Therapy (FIT) - Triple Therapy for Lymphatic Filariasis, Scabies and Soil Transmitted Helminths in Fiji Recruiting NCT03177993 3 drug dose - IDA;3 drug dose - IDA with second dose of ivermectin;2 drug dose - DA
49 Optimization of MDA With Existing Drug Regimens for LF: Monitoring Efficacy of Ongoing Treatment Programs in PNG Recruiting NCT03268252
50 Effect of Filarial Infection on Immune Responses in Latent Tuberculosis Recruiting NCT01547884

Search NIH Clinical Center for Filariasis

Cochrane evidence based reviews: filariasis

Genetic Tests for Filariasis

Anatomical Context for Filariasis

MalaCards organs/tissues related to Filariasis:

39
Testes, Breast, T Cells, Skin, Liver, B Cells, Endothelial

Publications for Filariasis

Articles related to Filariasis:

(show top 50) (show all 726)
id Title Authors Year
1
Continental-scale, data-driven predictive assessment of eliminating the vector-borne disease, lymphatic filariasis, in sub-Saharan Africa by 2020. ( 28950862 )
2017
2
Loa loa vectors Chrysops spp.: perspectives on research, distribution, bionomics, and implications for elimination of lymphatic filariasis and onchocerciasis. ( 28381279 )
2017
3
Generation and selection of naA^ve Fab library for parasitic antigen: Anti-BmSXP antibodies for lymphatic filariasis. ( 28833498 )
2017
4
Short-Course, High-Dose Rifampicin Achieves Wolbachia Depletion Predictive of Curative Outcomes in Preclinical Models of Lymphatic Filariasis and Onchocerciasis. ( 28303006 )
2017
5
How Frank Hawking, DM, and Table Salt, Helped Eliminate Lymphatic Filariasis From China. ( 28793168 )
2017
6
Assessing endgame strategies for the elimination of lymphatic filariasis: A model-based evaluation of the impact of DEC-medicated salt. ( 28785097 )
2017
7
Prevalence and risk factors associated with lymphatic filariasis in American Samoa after mass drug administration. ( 28794687 )
2017
8
Potential Value of Triple Drug Therapy with Ivermectin, Diethylcarbamazine, and Albendazole (IDA) to Accelerate Elimination of Lymphatic Filariasis and Onchocerciasis in Africa. ( 28056015 )
2017
9
The National Programme to Eliminate Lymphatic Filariasis from Ethiopia. ( 28878429 )
2017
10
The Current Status of Molecular Xenomonitoring for Lymphatic Filariasis and Onchocerciasis. ( 28756911 )
2017
11
Filariasis Orchitis-Differential for Acute Scrotum Pathology. ( 28507911 )
2017
12
Screening and evaluation of lymphatic filariasis in immigrants from endemic countries residing in a focus where it is considered eliminated in the Southern Region of Brazil: A risk of reemergence? ( 28823910 )
2017
13
Criteria to Stop Mass Drug Administration for Lymphatic Filariasis Have Been Achieved Throughout Plateau and Nasarawa States, Nigeria. ( 28749759 )
2017
14
Community-based field implementation scenarios of a short message service reporting tool for lymphatic filariasis case estimates in Africa and Asia. ( 28828375 )
2017
15
How much will it cost to eradicate lymphatic filariasis? An analysis of the financial and economic costs of intensified efforts against lymphatic filariasis. ( 28949987 )
2017
16
Imported Asymptomatic Bancroftian Filariasis Discovered from a Plasmodium vivax Infected Patient: A Case Report from Singapore. ( 28804661 )
2017
17
Improving the efficacy of a prophylactic vaccine formulation against lymphatic filariasis. ( 28828575 )
2017
18
Integrated morbidity management for lymphatic filariasis and podoconiosis, Ethiopia. ( 28867846 )
2017
19
Efficacy of the volatile oil from water celery (Helosciadium nodiflorum, Apiaceae) against the filariasis vector Culex quinquefasciatus, the housefly Musca domestica, and the African cotton leafworm Spodoptera littoralis. ( 28862791 )
2017
20
Pathological manifestations in lymphatic filariasis correlate with lack of inhibitory properties of IgG4 antibodies on IgE-activated granulocytes. ( 28742098 )
2017
21
Efficacy and tolerability of treatment with single doses of diethylcarbamazine (DEC) and DEC plus albendazole (ABZ) for three consecutive years in lymphatic filariasis: a field study in India. ( 28785847 )
2017
22
Twelve-month longitudinal parasitological assessment of lymphatic filariasis-positive individuals: impact of a biannual treatment with ivermectin and albendazole. ( 28891597 )
2017
23
Detecting and confirming residual hotspots of lymphatic filariasis transmission in American Samoa 8 years after stopping mass drug administration. ( 28922418 )
2017
24
Filariasis in Mandible and Maxilla: A Rare Entity-First Report of a Case. ( 27875706 )
2016
25
Successful Control of Soil-Transmitted Helminthiasis in School Age Children in Burkina Faso and an Example of Community-Based Assessment via Lymphatic Filariasis Transmission Assessment Survey. ( 27163294 )
2016
26
Detection of anti-filarial antibody among hydrocele patients living in an endemic area for filariasis. ( 28217582 )
2016
27
An asymptomatic inguinal swelling: Lymphatic filariasis. ( 27279316 )
2016
28
Unusual presentation of filariasis as an abscess: A case report. ( 27011444 )
2016
29
Evaluation of Lymphatic Filariasis and Onchocerciasis in Three Senegalese Districts Treated for Onchocerciasis with Ivermectin. ( 27926918 )
2016
30
Reducing the population requiring interventions against lymphatic filariasis in Africa. ( 26874545 )
2016
31
Intravitreal Filariasis: The Accidental Traveler. ( 26885575 )
2016
32
A Rare Case of Ovarian Filariasis in Abidjan. ( 27313932 )
2016
33
Doubts over India's deadline to defeat lymphatic filariasis. ( 27301812 )
2016
34
Filariasis of Stensen's Duct: An Index Case. ( 27867674 )
2016
35
On the Thermal Stability of the Diethylcarbamazine-Fortified TableA Salt Used in the Control of Lymphatic Filariasis. ( 27397435 )
2016
36
Global elimination of lymphatic filariasis. ( 28012944 )
2016
37
Sustaining Progress towards NTD Elimination: An Opportunity to Leverage Lymphatic Filariasis Elimination Programs to Interrupt Transmission of Soil-Transmitted Helminths. ( 27416062 )
2016
38
Minocycline as a re-purposed anti-Wolbachia macrofilaricide: superiority compared with doxycycline regimens in a murine infection model of human lymphatic filariasis. ( 26996237 )
2016
39
Bilateral Testicular Metastases and Filariasis in Prostatic Adenocarcinoma. ( 28017535 )
2016
40
Congenital filariasis caused by Setaria bidentata (Nematoda: Filarioidea) in the red brocket deer (Mazama americana). ( 27788338 )
2016
41
Effectiveness of a triple-drug regimen for global elimination of lymphatic filariasis: a modelling study. ( 28012943 )
2016
42
Global programme to eliminate lymphatic filariasis: progress report, 2015. ( 27758091 )
2016
43
Economic Costs and Benefits of a Community-Based Lymphedema Management Program for Lymphatic Filariasis in Odisha State, India. ( 27573626 )
2016
44
Current Epidemiological Assessment of Bancroftian Filariasis in Tanga Region, Northeastern Tanzania. ( 28050171 )
2016
45
Giant Scrotal Hydrocele and Bilateral Leg Lymphedema as Clinical Manifestation of Chronic Lymphatic Filariasis. ( 27840360 )
2016
46
Identification of immunodiagnostic antigens for cerebrospinal filariasis in horses by western blot analysis. ( 27073332 )
2016
47
Burden of lymphatic filariasis morbidity in an area of low endemicity in Brazil. ( 27427218 )
2016
48
Historic accounts of Mansonella parasitaemias in the South Pacific and their relevance to lymphatic filariasis elimination efforts today. ( 26972389 )
2016
49
Investment success in public health: An analysis of the cost-effectiveness and cost-benefit of the Global Programme to Eliminate Lymphatic Filariasis. ( 27956460 )
2016
50
Prevalence of Lymphatic Filariasis and Treatment Effectiveness of Albendazole/ Ivermectin in Individuals with HIV Co-infection in Southwest-Tanzania. ( 27070786 )
2016

Variations for Filariasis

Expression for Filariasis

Search GEO for disease gene expression data for Filariasis.

Pathways for Filariasis

Pathways related to Filariasis according to GeneCards Suite gene sharing:

(show top 50) (show all 68)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
14.05 CCL5 CHIT1 CTLA4 IFNG IL10 IL2
2
Show member pathways
13.7 CCL5 FLT4 IFNG IL10 IL2 IL5
3
Show member pathways
13.57 CCL5 FLT4 IFNG IL10 IL2 IL5
4
Show member pathways
13.46 CCL5 FLT4 IL10 IL2 IL5 IL6
5
Show member pathways
13.39 CCL5 IFNG IL10 IL2 IL5 IL6
6
Show member pathways
13.33 CCL5 FLT4 IL10 IL2 IL5 IL6
7
Show member pathways
13.29 IFNG IL2 TLR1 TLR2 TLR4 TLR6
8
Show member pathways
13.08 CCL5 IL6 TLR1 TLR2 TLR4 TLR6
9
Show member pathways
12.95 CTLA4 IFNG IL10 IL2 IL5 IL6
10
Show member pathways
12.9 CCL5 IFNG IL2 IL6 TLR2 TLR4
11
Show member pathways
12.8 FLT4 IL2 IL6 TLR1 TLR2 TLR4
12 12.73 FLT4 IL2 IL6 TLR2 TLR4 TNF
13
Show member pathways
12.73 FLT4 TLR1 TLR2 TLR4 TLR6 TLR9
14
Show member pathways
12.7 IFNG IL10 IL2 IL5 IL6 TLR2
15
Show member pathways
12.67 CCL5 IFNG IL10 IL2 IL6 TLR1
16
Show member pathways
12.65 IFNG IL10 IL2 IL6 TNF
17
Show member pathways
12.55 CTLA4 IFNG IL10 IL2 IL5 IL6
18 12.52 CCL5 CTLA4 IFNG IL10 IL2 TLR1
19
Show member pathways
12.48 TLR1 TLR2 TLR4 TLR6
20
Show member pathways
12.43 IFNG IL5 IL6 TLR2 TNF
21
Show member pathways
12.37 IFNG IL10 TLR2 TLR4 TNF
22
Show member pathways
12.32 IFNG IL6 TLR4 TNF
23
Show member pathways
12.32 IFNG IL10 IL2 IL5 IL6
24
Show member pathways
12.29 IFNG IL10 IL2 IL5 IL6 TNF
25
Show member pathways
12.28 IFNG IL6 TLR1 TLR2 TLR4 TLR6
26 12.25 IFNG IL6 TLR1 TLR2 TLR4 TLR6
27 12.2 TLR1 TLR2 TLR4 TLR6 TLR9
28 12.16 IFNG IL10 IL6 TLR1 TLR2 TLR4
29
Show member pathways
12.15 IL2 IL5 TLR1 TLR2 TLR4 TLR6
30 12.14 IFNG IL2 IL6 TLR4 TNF
31 12.13 IFNG IL10 IL2 IL5 IL6 TNF
32
Show member pathways
12.05 IFNG IL6 TLR1 TLR2 TLR4 TLR6
33 12.04 IFNG IL10 IL6 TLR2 TLR4 TNF
34 11.98 CCL5 CTLA4 IFNG IL6 TLR2 TLR4
35 11.96 IFNG IL10 IL2 IL6
36 11.96 TLR1 TLR2 TLR4 TLR6 TLR9
37 11.95 CCL5 IL6 TNF
38 11.93 IFNG IL10 IL2 IL5 TNF
39 11.92 IFNG IL2 IL5 IL6
40 11.91 IFNG IL6 TLR4
41 11.91 IFNG IL10 IL2 IL6 TLR9 TNF
42 11.9 IL5 IL6 TNF
43
Show member pathways
11.9 CTLA4 IFNG IL2 IL5 TNF
44 11.88 IL10 IL6 TLR4 TNF
45 11.84 IFNG IL6 TLR4
46 11.79 CCL5 IL5 IL6 TNF
47
Show member pathways
11.79 IFNG IL2 IL6 TNF
48 11.73 IL6 TLR2 TLR4 TNF
49
Show member pathways
11.69 IFNG IL2 TNF
50 11.69 IFNG IL2 IL6 TNF

GO Terms for Filariasis

Cellular components related to Filariasis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.95 CTLA4 FLT4 TLR1 TLR2 TLR4 TLR6
2 extracellular region GO:0005576 9.7 ALB CCL5 CHIT1 FLT4 IFNG IL10
3 membrane raft GO:0045121 9.62 TLR1 TLR2 TLR6 TNF
4 external side of plasma membrane GO:0009897 9.55 CTLA4 IFNG IL6 TLR4 TNF
5 phagocytic vesicle membrane GO:0030670 9.54 TLR1 TLR2 TLR6
6 extracellular space GO:0005615 9.32 ALB CCL5 CHIT1 IFNG IL10 IL2
7 Toll-like receptor 1-Toll-like receptor 2 protein complex GO:0035354 9.26 TLR1 TLR2

Biological processes related to Filariasis according to GeneCards Suite gene sharing:

(show top 50) (show all 97)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 9.99 IL10 IL5 IL6 TNF
2 cellular response to lipopolysaccharide GO:0071222 9.98 IFNG IL10 IL6 TLR4 TNF
3 defense response to Gram-positive bacterium GO:0050830 9.95 IL6 TLR2 TNF
4 positive regulation of JNK cascade GO:0046330 9.95 FLT4 TLR4 TLR9 TNF
5 defense response to Gram-negative bacterium GO:0050829 9.94 IL6 TLR4 TLR9
6 positive regulation of inflammatory response GO:0050729 9.94 IL2 TLR2 TLR4 TLR9
7 response to insulin GO:0032868 9.93 IL10 IL6 TLR2
8 response to glucocorticoid GO:0051384 9.93 IL10 IL6 TNF
9 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.93 CCL5 IFNG IL2 IL6
10 positive regulation of T cell proliferation GO:0042102 9.93 CCL5 IFNG IL2 IL6
11 regulation of insulin secretion GO:0050796 9.92 CCL5 IFNG TNF
12 positive regulation of smooth muscle cell proliferation GO:0048661 9.92 CCL5 IL6 TNF
13 humoral immune response GO:0006959 9.91 IFNG IL6 TNF
14 positive regulation of tumor necrosis factor production GO:0032760 9.91 IFNG TLR2 TLR4 TLR9
15 defense response to bacterium GO:0042742 9.91 IFNG IL10 TLR1 TLR4 TLR6 TLR9
16 positive regulation of cell adhesion GO:0045785 9.9 CCL5 IFNG TNF
17 positive regulation of interferon-gamma production GO:0032729 9.9 IL2 TLR4 TNF
18 positive regulation of JUN kinase activity GO:0043507 9.89 TLR6 TLR9 TNF
19 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.88 IL6 TLR2 TLR4 TLR9 TNF
20 response to bacterium GO:0009617 9.87 CHIT1 IL6 TLR4
21 lipopolysaccharide-mediated signaling pathway GO:0031663 9.86 CCL5 TLR2 TLR4 TNF
22 positive regulation of interferon-beta production GO:0032728 9.85 TLR2 TLR4 TLR9
23 positive regulation of interleukin-10 production GO:0032733 9.85 TLR2 TLR4 TLR9
24 defense response to protozoan GO:0042832 9.85 IFNG IL10 IL6
25 positive regulation of JAK-STAT cascade GO:0046427 9.85 CCL5 IL5 IL6
26 positive regulation of interleukin-8 production GO:0032757 9.85 TLR2 TLR4 TLR9 TNF
27 positive regulation of interleukin-6 production GO:0032755 9.85 IL6 TLR2 TLR4 TLR9 TNF
28 negative regulation of growth of symbiont in host GO:0044130 9.84 IFNG IL10 TNF
29 negative regulation of interleukin-6 production GO:0032715 9.84 IL10 TLR4 TLR9 TNF
30 cell activation GO:0001775 9.83 TLR1 TLR2 TLR6
31 toll-like receptor signaling pathway GO:0002224 9.83 TLR1 TLR2 TLR4 TLR6 TLR9
32 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.82 TLR2 TLR4 TLR9
33 positive regulation of interleukin-12 production GO:0032735 9.81 IFNG TLR2 TLR4 TLR9
34 response to molecule of bacterial origin GO:0002237 9.8 IL10 TLR2 TLR9
35 positive regulation of NF-kappaB import into nucleus GO:0042346 9.8 TLR2 TLR4 TLR9 TNF
36 I-kappaB phosphorylation GO:0007252 9.79 TLR2 TLR4 TLR9
37 positive regulation of immunoglobulin secretion GO:0051024 9.79 IL2 IL5 IL6
38 microglial cell activation GO:0001774 9.78 TLR2 TLR6
39 cellular response to hepatocyte growth factor stimulus GO:0035729 9.77 IL10 IL6
40 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.77 IL10 TNF
41 positive regulation of protein import into nucleus, translocation GO:0033160 9.77 IFNG IL6
42 positive regulation of MAPK cascade GO:0043410 9.77 FLT4 IL6
43 positive regulation of podosome assembly GO:0071803 9.77 IL5 TNF
44 T-helper 1 type immune response GO:0042088 9.77 TLR4 TLR6
45 positive regulation of interleukin-6 biosynthetic process GO:0045410 9.77 IFNG TLR1 TLR6
46 positive regulation of MHC class II biosynthetic process GO:0045348 9.77 IFNG IL10 TLR4
47 positive regulation of tumor necrosis factor biosynthetic process GO:0042535 9.76 TLR1 TLR4
48 negative regulation of interleukin-17 production GO:0032700 9.76 IFNG TLR4
49 cellular response to lipoteichoic acid GO:0071223 9.76 TLR2 TLR4
50 positive regulation of isotype switching to IgG isotypes GO:0048304 9.76 IFNG IL2

Molecular functions related to Filariasis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 transmembrane signaling receptor activity GO:0004888 9.71 TLR1 TLR4 TLR6 TLR9
2 receptor activity GO:0004872 9.67 TLR1 TLR2 TLR4 TLR6
3 growth factor activity GO:0008083 9.56 IL10 IL2 IL5 IL6
4 lipopolysaccharide receptor activity GO:0001875 9.32 TLR2 TLR4
5 cytokine activity GO:0005125 9.17 CCL5 IFNG IL10 IL2 IL5 IL6
6 Toll-like receptor 2 binding GO:0035663 9.16 TLR1 TLR6
7 lipopeptide binding GO:0071723 9.13 TLR1 TLR2 TLR6

Sources for Filariasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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