MCID: FLR002
MIFTS: 60

Filariasis malady

Infectious diseases category

Summaries for Filariasis

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A parasitic helminthiasis infectious disease that involves parasitic infection of the lymphatics and subcutaneous tissue by nematodes of the superfamily filarioidea.

MalaCards: Filariasis, also known as disease due to superfamily filarioidea, is related to onchocerciasis and malaria. An important gene associated with Filariasis is CHIT1 (chitinase 1 (chitotriosidase)), and among its related pathways are Malaria and IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types. The compounds amphotericin b and cyclosporin a have been mentioned in the context of this disorder. Affiliated tissues include testes, breast and t cells, and related mouse phenotypes are no phenotypic analysis and immune system.

Wikipedia:63 Filariasis (or philariasis) is a parasitic disease that is caused by thread-like roundworms belonging to... more...

Aliases & Classifications for Filariasis

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8Disease Ontology, 10DISEASES, 44Novoseek, 48Orphanet, 60UMLS, 27ICD9CM, 56SNOMED-CT, 39NCIt, 34MeSH, 26ICD10 via Orphanet, 35MESH via Orphanet, 61UMLS via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases


Characteristics (Orphanet epidemiological data):

48
filariasis:
Inheritance: Sporadic; Age of onset: Variable


Aliases & Descriptions:

filariasis 8 10 44 48 60
disease due to superfamily filarioidea 8
filariasis, unspecified 8
unspecified filariasis 8
filariasis nos 8


External Ids:

Disease Ontology8 DOID:1080
ICD9CM27 125.9
NCIt39 C34611
MeSH34 D005368
ICD10 via Orphanet26 B72, B73, B74.0 B74.1, B74.2, B74.3, B74.4, B74.8, B74.9, more
MESH via Orphanet35 D005368
UMLS via Orphanet61 C0016085

Related Diseases for Filariasis

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Filariasis:



Diseases related to filariasis

Clinical Features for Filariasis

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Drugs & Therapeutics for Filariasis

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Filariasis

Drug clinical trials:

Search ClinicalTrials for Filariasis

Search NIH Clinical Center for Filariasis

Search CenterWatch for Filariasis

Genetic Tests for Filariasis

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Anatomical Context for Filariasis

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32MalaCards
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MalaCards organs/tissues related to Filariasis:

32
Testes, Breast, T cells, B cells, Kidney, Endothelial

Animal Models for Filariasis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Filariasis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000301210.2KIF22, IGHE, PRDX4
2MP:00053879.3IL5, TLR4, TLR2, TLR1, ICOS, TNFRSF18
3MP:00053979.3TLR4, TLR2, ICOS, TNFRSF18, IGHE, CD27

Publications for Filariasis

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50PubMed
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Articles related to Filariasis:

(show top 50)    (show all 580)
idTitleAuthorsYear
1
Urban lymphatic filariasis in the city of Tanga, Tanzania, after seven rounds of mass drug administration. (24135628)
2013
2
A comprehensive, model-based review of vaccine and repeat infection trials for filariasis. (23824365)
2013
3
Single multivalent vaccination boosted by trickle larval infection confers protection against experimental lymphatic filariasis. (23735679)
2013
4
Self care integrative treatment demonstrated in rural community setting improves health related quality of life of lymphatic filariasis patients in endemic villages. (23499714)
2013
5
A case report of Brugian filariasis outside an endemic area in Thailand. (23067513)
2013
6
A practical strategy for responding to a case of lymphatic filariasis post-elimination in Pacific Islands. (23890320)
2013
7
Studies on the impact of biosynthesized silver nanoparticles (AgNPs) in relation to malaria and filariasis vector control against Anopheles stephensi Liston and Culex quinquefasciatus Say (Diptera: Culicidae). (23064800)
2013
8
Rapid diagnostics for the endgame in lymphatic filariasis elimination. (23843491)
2013
9
Monitoring and evaluation of lymphatic filariasis interventions: an improved PCR-based pool screening method for high throughput Wuchereria bancrofti detection using dried blood spots. (23597068)
2013
10
Laboratory detection of strongyloidiasis: IgG-, IgG4 - and IgE-ELISAs and cross-reactivity with lymphatic filariasis. (23448095)
2013
11
Evidence for stopping mass drug administration for lymphatic filariasis in some, but not all local government areas of Plateau and Nasarawa States, Nigeria. (22855758)
2012
12
Transmission assessment surveys in the Global Programme to Eliminate Lymphatic Filariasis: WHO position statement. (23213667)
2012
13
Issues in delivering morbidity management for lymphatic filariasis elimination: a study in Pondicherry, South India. (22654597)
2012
14
Green synthesis of silver nanoparticles for the control of mosquito vectors of malaria, filariasis, and dengue. (22022807)
2012
15
Wolbachia and its implications for the immunopathology of filariasis. (22214329)
2012
16
Laboratory observations on the larvicidal efficacy of three plant species against mosquito vectors of malaria, dengue/dengue hemorrhagic fever (DF/DHF) and lymphatic filariasis in the semi-arid desert. (23029912)
2012
17
Lymphoscintigraphy in unilateral lower limb and scrotal lymphedema caused by filariasis. (23222136)
2012
18
Biochemical characterization and evaluation of a Brugia malayi small heat shock protein as a vaccine against lymphatic filariasis. (22496777)
2012
19
Vector mosquitoes of filariasis in Japan. (22028600)
2011
20
Giant vulval filariasis: an uncommon problem in endemic region. (21910094)
2011
21
Larvicidal activity of synthesized silver nanoparticles using Eclipta prostrata leaf extract against filariasis and malaria vectors. (21419749)
2011
22
Filariasis presenting as a scrotal nodule in a 2 year old child: a case report. (21771446)
2011
23
Declining trend of lymphatic filariasis from rural areas of Koraput district of Odisha State. (23785747)
2011
24
Genital filariasis masquerading as testicular torsio. (21715738)
2011
25
Brugia filariasis differentially modulates persistent Helicobacter pylori gastritis in the gerbil model. (20685294)
2010
26
Filarial selenium glutathione peroxidase: a probable immunodiagnostic marker for lymphatic filariasis. (20227740)
2010
27
Post-kidney transplantation lymphocele due to a lymphatic filariasis. (20832594)
2010
28
A pilot program of mass surgery weeks for treatment of hydrocele due to lymphatic filariasis in central Nigeria. (19270297)
2009
29
Lymphatic filariasis elimination programme in India: progress and challenges. (19008150)
2009
30
Detection of dog filariasis in Marajo Island, Brazil by classical and molecular methods. (19693539)
2009
31
Role of vector control in the global program to eliminate lymphatic filariasis. (18798707)
2009
32
A study on coverage and compliance of mass drug administration programme for elimination of filariasis in Udupi district, Karnataka, India. (19724089)
2009
33
An Epidemiological Study of Filariasis in a Village of District Datia, MP. (20049296)
2009
34
Seasonal changes of infectivity rates of Bancroftian filariasis vectors in coast province, Kenya. (19724086)
2009
35
Filariasis and lymphoedema. (19825106)
2009
36
Simulation models examining the effect of Brugian filariasis on dengue epidemics. (19141838)
2009
37
Global programme to eliminate lymphatic filariasis. (18788146)
2008
38
An unusual presentation of filariasis: a case report. (18499995)
2008
39
Eliminating lymphatic filariasis: a view from the field. (18579875)
2008
40
Intravitreal live adult Brugian filariasis. (18158414)
2008
41
Global programme to eliminate lymphatic filariasis. (17948605)
2007
42
Case report: effects of diethylcarbamazine and thiabendazole combination against Mansonella perstans filariasis. (18412041)
2007
43
Tropical Diseases Targeted for Elimination: Chagas Disease, Lymphatic Filariasis, Onchocerciasis, and Leprosy (21250324)
2006
44
Knowledge and beliefs about elephantiasis and hydrocele of lymphatic filariasis and some socio-demographic determinants in an endemic community of Eastern India. (15037042)
2004
45
Histoid leprosy with filariasis. (17656997)
2002
46
Call to consolidate achievements for onchocerciasis and lymphatic filariasis control. (11756020)
2001
47
Inflammatory cytokines following diethylcarbamazine (DEC) treatment of different clinical groups in lymphatic filariasis. (10717762)
1999
48
Evaluating the detection of circulating filarial antigen in diagnosis of bancroftian filariasis and filarial hydrocele. (8918042)
1996
49
Specific T cell unresponsiveness in human filariasis: diversity in underlying mechanisms. (8817605)
1995
50
Filariasis diagnosed by cytologic examination of hydrocele fluid. (4129938)
1974

Genetic Variations for Filariasis

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Expression for genes affiliated with Filariasis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Filariasis

Search GEO for disease gene expression data for Filariasis.

Pathways for genes affiliated with Filariasis

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29KEGG, 52R&D Systems, 37NCBI BioSystems Database, 51QIAGEN, 4Cell Signaling Technology, 12EMD Millipore, 53Reactome, 59Tocris Bioscience, 55SinoBiological
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Pathways related to Filariasis according to GeneCards/GeneDecks:

(show all 24)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.3TLR2, TLR4
210.3IL13, IL5
310.2TLR4, TLR2, IL10
410.2IL5, IL10, IL13
510.2IL13, IL10, IL5
610.2IL13, IL10, IL5
710.2TLR4, TLR2, TLR1
8
Immune response Bacterial infections in normal airways
10.2TLR1, TLR2, TLR4
9
Hide members
10.2TLR4, TLR2, TLR1
1010.2TLR1, TLR2, TLR4
1110.2TLR4, TLR2, TLR1
12
Hide members
10.2TLR1, TLR2, TLR4
1310.2IL5, IL10, IGHE
1410.1TLR4, TLR2, TLR1, IL10
15
Hide members
10.1TLR4, TLR2, TLR1, IL10
16
Hide members
10.1IL10, TLR1, TLR2, TLR4
17
Hide members
10.1IL5, IL10, IL13, ICOS
18
Hide members
10.1TNFRSF18, TLR1, TLR2, TLR4
19
Hide members
10.0TLR4, TLR2, IL13, IL10, IL5
20
Hide members
10.0IL5, IL13, TLR1, TLR2, TLR4
21
Hide members
10.0TLR4, TLR2, TLR1, TNFRSF18, CD27
22
Hide members
9.9TLR4, TLR2, TLR1, ICOS, IGHE, IL5
23
Hide members
9.8TLR4, TLR2, TLR1, TNFRSF18, IL13, IL10
24
Hide members
9.8TLR4, TNFRSF18, PPP1R14B, CD27, IL13, IL10

Compounds for genes affiliated with Filariasis

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Sources:
44Novoseek, 28IUPHAR, 59Tocris Bioscience, 2BitterDB, 11DrugBank, 49PharmGKB, 24HMDB
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Compounds related to Filariasis according to GeneCards/GeneDecks:

(show top 50)    (show all 80)
idCompoundScoreTop Affiliating Genes
1amphotericin b4410.8IL13
2cyclosporin a44 28 5912.8IGHE
3cycloheximide4410.7TLR2
4rantes4410.7TLR2, TLR4
5hydrocortisone44 2 59 1113.7IGHE
6pam3csk45910.6TLR1, TLR2, TLR4
7pam2csk45910.6TLR2, TLR1, TLR4
8poly(i:c)5910.6TLR4, TLR2, TLR1
9glucuronoxylomannan4410.6TLR4, TLR2, IL10
10omalizumab44 1111.6IL5, IL13, IGHE
11gm-csf44 2811.6IL10
12resiquimod44 5911.6TLR1, TLR4, TLR2
13trimellitic anhydride4410.6IGHE, IL13
14ovomucoid4410.6IL5, IGHE, IL13
15glatiramer acetate44 1111.6IL10, IL5, IL13
16arabinogalactan4410.6TLR4, TLR2
17as 10159 4411.6IL13, IL10, IL5
18penicillin4410.6IL5, IL13, IGHE
19il-124410.6IL13, IL10, IL5
20flagellin44 2811.6TLR1, TLR2, TLR4
21p 2774410.6TLR2, IL10
22polyinosinic-polycytidylic acid4410.5TLR4, IL10, TLR2, IL5
23praziquantel44 1111.5IL5, IGHE, IL13, IL10
24methyltetrahydrophthalic anhydride4410.5IL13, IGHE
25montelukast44 49 28 1113.5IL13, IL5, IL10, IGHE
26lipoteichoic acid4410.5TLR4, TLR2, TLR1, IL10
27salbutamol44 49 28 11 2414.5IL10, IL5, IGHE, IL13
28ccl344 2811.5IL13, IL10, TLR4, TLR2
29peptidoglycan44 2811.5TLR1, TLR2, IL10, TLR4
30tarc4410.5IL13, IL5, IGHE, IL10
31polymyxin b4410.5IL10, TLR2, TLR4
32il 104410.5IL5, IL10, IL13, TLR4, TLR2
33imiquimod44 28 59 1113.5TLR4, TLR1, IL5, TLR2, IL10
34allergens4410.5IL5, IL13, TLR4, IGHE, IL10
35tacrolimus44 49 1112.4TLR2, TLR4, IL13, IL5, IL10
36budesonide44 49 1112.4IL5, IGHE, IL13
37prednisolone44 28 1112.4IL10, IL13, IGHE, IL5
38fluticasone propionate44 49 59 1113.4IL5, IGHE, IL13
39sb 20358044 5911.4IL5, TLR4, TLR2, IL13, IL10
40polysaccharide4410.3TLR4, TLR2, CHIT1, IL13, IGHE
41histamine44 28 2412.3IGHE, IL5, IL10, TLR2, IL13, TLR4
42vitamin d4410.3TLR4, TLR2, IL10, IGHE, IL5
43mannose4410.3TLR4, CHIT1, IL13, TLR2
44thyroxine44 2411.3IGHE, IL13, IL10, IL5
45pgd24410.3IGHE, IL13, IL5
46ionomycin4410.2IL13, IL5, IL10, TLR2
47poly(i-c)4410.1IL5, TLR4, TLR2
48diaminopimelic acid4410.0TLR4, TLR2
49dexamethasone44 49 28 1112.9TLR2, IGHE, IL13, IL10, IL5, TLR4
50vegf449.9IL13, IGHE, TLR2, TLR4, IL5, IL10

GO Terms for genes affiliated with Filariasis

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16Gene Ontology
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Cellular components related to Filariasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Toll-like receptor 1-Toll-like receptor 2 protein complexGO:03535410.0TLR2, TLR1
2integral to plasma membraneGO:0058879.9CD27, TNFRSF18, ICOS, TLR1, TLR2, TLR4
3external side of plasma membraneGO:0098979.8IL13, CD27, TNFRSF18, ICOS, TLR2, TLR4

Biological processes related to Filariasis according to GeneCards/GeneDecks:

(show all 20)
idNameGO IDScoreTop Affiliating Genes
1detection of triacyl bacterial lipopeptideGO:04249510.6TLR1, TLR2
2cellular response to triacyl bacterial lipopeptideGO:07172710.6TLR1, TLR2
3detection of diacyl bacterial lipopeptideGO:04249610.6TLR2, TLR1
4positive regulation of macrophage cytokine productionGO:06090710.6TLR2, TLR4
5cellular response to lipoteichoic acidGO:07122310.5TLR4, TLR2
6positive regulation of tumor necrosis factor biosynthetic processGO:04253510.5TLR1, TLR2, TLR4
7I-kappaB phosphorylationGO:00725210.5TLR4, TLR2, PRDX4
8regulation of cytokine secretionGO:05070710.5TLR4, TLR1
9positive regulation of MHC class II biosynthetic processGO:04534810.5TLR4, IL10
10positive regulation of B cell proliferationGO:03089010.5IL5, IL13, TLR4
11negative regulation of interleukin-17 productionGO:03270010.5TLR2, TLR4
12macrophage activationGO:04211610.4TLR1, TLR4
13positive regulation of nitric-oxide synthase biosynthetic processGO:05177010.4TLR2, TLR4
14inflammatory responseGO:00695410.3TLR2, TLR1, IL13, IL10, IL5
15MyD88-dependent toll-like receptor signaling pathwayGO:00275510.3TLR4, TLR2, TLR1
16positive regulation of chemokine productionGO:03272210.3TLR2, TLR4
17negative regulation of interleukin-12 productionGO:03269510.3IL10, TLR2
18T-helper 1 type immune responseGO:04208810.2TLR4, TLR1
19immune responseGO:00695510.1IL5, TLR4, TLR2, TLR1, ICOS, CHIT1
20negative regulation of growth of symbiont in hostGO:04413010.0IL10, TLR2

Molecular functions related to Filariasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1lipopolysaccharide receptor activityGO:00187510.3TLR2, TLR4
2transmembrane signaling receptor activityGO:0048889.8CD27, TLR1, TLR2, TLR4

Products for genes affiliated with Filariasis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Filariasis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet