MCID: FLR002
MIFTS: 50

Filariasis malady

Infectious category

Summaries for Filariasis

Sources:
8Disease Ontology, 64Wikipedia, 33MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Disease Ontology:8 A parasitic helminthiasis infectious disease that involves parasitic infection of the lymphatics and subcutaneous tissue by nematodes of the superfamily filarioidea.

MalaCards: Filariasis, also known as disease due to superfamily filarioidea, is related to onchocerciasis and helminthiasis. An important gene associated with Filariasis is CHIT1 (chitinase 1 (chitotriosidase)), and among its related pathways are Malaria and IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types. The compounds amphotericin b and cyclosporin a have been mentioned in the context of this disorder. Related mouse phenotypes are no phenotypic analysis and immune system.

Wikipedia:64 Filariasis (philariasis) is a parasitic disease (usually an infectious tropical disease) that is caused... more...

Aliases & Classifications for Filariasis

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 49Orphanet, 61UMLS, 27ICD9CM, 57SNOMED-CT, 40NCIt, 35MeSH, 26ICD10 via Orphanet, 36MESH via Orphanet, 62UMLS via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious


Characteristics (Orphanet epidemiological data):

49
filariasis:
Inheritance: Sporadic; Age of onset: Variable


Aliases & Descriptions:

filariasis 8 10 45 49 61
disease due to superfamily filarioidea 8
filariasis, unspecified 8
unspecified filariasis 8
filariasis nos 8


External Ids:

Disease Ontology8 DOID:1080
ICD9CM27 125.9
NCIt40 C34611
MeSH35 D005368
ICD10 via Orphanet26 B72, B73, B74
MESH via Orphanet36 D005368
UMLS via Orphanet62 C0016085

Related Diseases for Filariasis

Sources:
17GeneCards, 18GeneDecks
See all sources

Graphical network of the top 20 diseases related to Filariasis:



Diseases related to filariasis

Clinical Features for Filariasis

Drugs & Therapeutics for Filariasis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Filariasis

Drug clinical trials:

Search ClinicalTrials for Filariasis

Search NIH Clinical Center for Filariasis

Search CenterWatch for Filariasis

Genetic Tests for Filariasis

Anatomical Context for Filariasis

Animal Models for Filariasis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Filariasis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000301210.2KIF22, IGHE, PRDX4
2MP:00053879.3IL5, TLR4, TLR2, TLR1, ICOS, TNFRSF18
3MP:00053979.3TLR4, TLR2, ICOS, TNFRSF18, IGHE, CD27

Publications for Filariasis

Sources:
51PubMed
See all sources

Articles related to Filariasis:

(show top 50)    (show all 581)
idTitleAuthorsYear
1
Perceptive solutions to anti-filarial chemotherapy of lymphatic filariasis from the plethora of nanomedical sciences. (24004100)
2014
2
Malaria and lymphatic filariasis: the case for integrated vector management. (23084831)
2013
3
Long-lasting insecticidal nets are synergistic with mass drug administration for interruption of lymphatic filariasis transmission in Nigeria. (24205421)
2013
4
Coverage and awareness of and compliance with mass drug administration for elimination of lymphatic filariasis in Burdwan District, West Bengal, India. (23930334)
2013
5
Modelling co-infection with malaria and lymphatic filariasis. (23785271)
2013
6
The symbiotic role of Wolbachia in Onchocercidae and its impact on filariasis. (23398406)
2013
7
The history of the elimination of lymphatic filariasis in China. (24289733)
2013
8
Urban lymphatic filariasis in the metropolis of Dar es Salaam, Tanzania. (24289718)
2013
9
Mosquito-parasite interactions can shape filariasis transmission dynamics and impact elimination programs. (24069488)
2013
10
IL-4-, TGF-I^-, and IL-1-dependent expansion of parasite antigen-specific Th9 cells is associated with clinical pathology in human lymphatic filariasis. (23913964)
2013
11
Population ecology of mosquitoes and the status of bancroftian filariasis in El Dakahlia Governorate, the Nile delta, Egypt. (23697019)
2013
12
Lymphatic filariasis mapping by immunochromatographic test cards and baseline microfilaria survey prior to mass drug administration in Sierra Leone. (22236419)
2012
13
Filariasis in an infant with B-cell acute lymphoblastic leukemia: a rare enigma. (23543795)
2012
14
Studies on Fungal Cultural Filtrates against Adult Culex quinquefasciatus (Diptera: Culicidae) a Vector of Filariasis. (22132305)
2011
15
Applications of Self-Organising Map (SOM) for prioritisation of endemic zones of filariasis in Andhra Pradesh, India. (21954673)
2011
16
Managing morbidity and preventing disability in the Global Programme to Eliminate Lymphatic Filariasis: WHO position statement. (22191103)
2011
17
Diurnally subperiodic filariasis in India-prospects of elimination: precept to action? (21286754)
2011
18
Brugian filariasis in Japan. (22028598)
2011
19
Epidemiological and entomological evaluations after six years or more of mass drug administration for lymphatic filariasis elimination in Nigeria. (22022627)
2011
20
Loss of genetic diversity in Culex quinquefasciatus targeted by a lymphatic filariasis vector control program in Recife, Brazil. (21737112)
2011
21
The economic benefits resulting from the first 8 years of the Global Programme to Eliminate Lymphatic Filariasis (2000-2007). (20532228)
2010
22
Lymphatic filariasis in Andhra Pradesh Paper Mill Colony, Rajahmundry, India after nine rounds of MDA programme. (20231775)
2010
23
The stigmata and discrimination experienced, in southern India, by cases of lymphatic filariasis. (20819310)
2010
24
A single dose of doxycycline in combination with diethylcarbamazine for treatment of bancroftian filariasis. (21073054)
2010
25
Elimination of lymphatic filariasis: do we have the drugs to complete the job? (20847694)
2010
26
Elimination of lymphatic filariasis in the Republic of Korea: an epidemiological survey of formerly endemic areas, 2002-2006. (19228352)
2009
27
Clinicians' attitude on mass drug administration under the program to eliminate lymphatic filariasis: a qualitative study from Orissa, India. (19124342)
2009
28
Intrascrotal nodules in adult men as a marker for filarial granuloma in a bancroftian filariasis-endemic area. (19635891)
2009
29
Filariasis: diagnosis and treatment. (19889133)
2009
30
Isolation of an antigen fraction from Setaria cervi adults having potential for immunodiagnosis of human filariasis. (19860586)
2009
31
Protective immunity in human filariasis: a role for parasite-specific IgA responses. (18588480)
2008
32
Filariasis caused by Loa loa is also a cause of angioedema. (18823842)
2008
33
Zoonotic deep cutaneous filariasis--three pediatric cases from QuAcbec, Canada. (18429786)
2008
34
Larval susceptibility of Aloe barbadensis and Cannabis sativa against Culex quinquefasciatus, the filariasis vector. (19297997)
2008
35
Mathematical models for lymphatic filariasis transmission and control: Challenges and prospects. (18275593)
2008
36
Treatment for lymphatic filariasis and elephantiasis. (18270350)
2008
37
National mass drug administration costs for lymphatic filariasis elimination. (17989784)
2007
38
Epidemiological modelling for monitoring and evaluation of lymphatic filariasis control. (18063097)
2007
39
A critical appraisal of molecular xenomonitoring as a tool for assessing progress toward elimination of Lymphatic Filariasis. (17978055)
2007
40
Eliminating lymphatic filariasis, onchocerciasis, and schistosomiasis from the americas: breaking a historical legacy of slavery. (18060085)
2007
41
Circulating filarial antigen in serum and hydrocele fluid from individuals living in an endemic area for bancroftian filariasis. (17901645)
2007
42
Endpoints for lymphatic filariasis programs. (17553278)
2007
43
Transcriptional control of impaired Th1 responses in patent lymphatic filariasis by T-box expressed in T cells and suppressor of cytokine signaling genes. (15908366)
2005
44
Management of filariasis using prediction rules derived from data mining. (17597842)
2005
45
Interleukin-10 (IL-10) counterregulates IL-4-dependent effector mechanisms in Murine Filariasis. (15501755)
2004
46
Immunoregulation in human lymphatic filariasis: the role of interleukin 10. (7501419)
1995
47
Elevated levels of T cell activation antigen CD27 and increased interleukin-4 production in human lymphatic filariasis. (7903075)
1993
48
Diethylcarbamazine in the control of splenomegaly associated with Bancroftian filariasis in the Ok Tedi area of Papua New Guinea. (1475824)
1992
49
Role of filariasis in endomyocardial fibrosis. (7153486)
1982
50
Relationship of tropical hydrocele to filariasis in Puerto Rico. (13848470)
1960

Genetic Variations for Filariasis

Expression for genes affiliated with Filariasis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Filariasis

Search GEO for disease gene expression data for Filariasis.

Pathways for genes affiliated with Filariasis

Sources:
30KEGG, 53R&D Systems, 38NCBI BioSystems Database, 52QIAGEN, 4Cell Signaling Technology, 12EMD Millipore, 54Reactome, 60Tocris Bioscience, 56SinoBiological
See all sources

Pathways related to Filariasis according to GeneCards/GeneDecks:

(show all 24)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.3TLR2, TLR4
210.3IL13, IL5
310.2TLR4, TLR2, IL10
410.2IL5, IL10, IL13
510.2IL13, IL10, IL5
610.2IL13, IL10, IL5
710.2TLR4, TLR2, TLR1
8
Immune response Bacterial infections in normal airways
10.2TLR1, TLR2, TLR4
9
Hide members
10.2TLR4, TLR2, TLR1
1010.2TLR1, TLR2, TLR4
1110.2TLR4, TLR2, TLR1
12
Hide members
10.2TLR1, TLR2, TLR4
1310.2IL5, IL10, IGHE
1410.1TLR4, TLR2, TLR1, IL10
15
Hide members
10.1TLR4, TLR2, TLR1, IL10
16
Hide members
10.1IL10, TLR1, TLR2, TLR4
17
Hide members
10.1IL5, IL10, IL13, ICOS
18
Hide members
10.1TNFRSF18, TLR1, TLR2, TLR4
19
Hide members
10.0TLR4, TLR2, IL13, IL10, IL5
20
Hide members
10.0IL5, IL13, TLR1, TLR2, TLR4
21
Hide members
10.0TLR4, TLR2, TLR1, TNFRSF18, CD27
22
Hide members
9.9TLR4, TLR2, TLR1, ICOS, IGHE, IL5
23
Hide members
9.8TLR4, TLR2, TLR1, TNFRSF18, IL13, IL10
24
Hide members
9.8TLR4, TNFRSF18, PPP1R14B, CD27, IL13, IL10

Compounds for genes affiliated with Filariasis

Sources:
45Novoseek, 29IUPHAR, 60Tocris Bioscience, 2BitterDB, 11DrugBank, 50PharmGKB, 24HMDB
See all sources

Compounds related to Filariasis according to GeneCards/GeneDecks:

(show top 50)    (show all 80)
idCompoundScoreTop Affiliating Genes
1amphotericin b4510.8IL13
2cyclosporin a45 29 6012.8IGHE
3cycloheximide4510.7TLR2
4rantes4510.7TLR2, TLR4
5hydrocortisone45 2 60 1113.7IGHE
6pam2csk46010.6TLR4, TLR2, TLR1
7pam3csk46010.6TLR4, TLR2, TLR1
8poly(i:c)6010.6TLR4, TLR1, TLR2
9glucuronoxylomannan4510.6IL10, TLR2, TLR4
10omalizumab45 1111.6IL5, IL13, IGHE
11gm-csf45 2911.6IL10
12resiquimod45 6011.6TLR1, TLR2, TLR4
13trimellitic anhydride4510.6IL13, IGHE
14ovomucoid4510.6IGHE, IL13, IL5
15glatiramer acetate45 1111.6IL5, IL10, IL13
16arabinogalactan4510.6TLR4, TLR2
17as 10160 4511.6IL13, IL10, IL5
18penicillin4510.6IGHE, IL13, IL5
19flagellin45 2911.6TLR4, TLR2, TLR1
20il-124510.6IL13, IL10, IL5
21p 2774510.6TLR2, IL10
22polyinosinic-polycytidylic acid4510.5TLR4, TLR2, IL10, IL5
23praziquantel45 1111.5IGHE, IL13, IL10, IL5
24methyltetrahydrophthalic anhydride4510.5IGHE, IL13
25montelukast45 50 29 1113.5IGHE, IL13, IL10, IL5
26lipoteichoic acid4510.5TLR4, TLR2, TLR1, IL10
27salbutamol45 50 29 11 2414.5IGHE, IL13, IL10, IL5
28ccl345 2911.5TLR4, TLR2, IL13, IL10
29peptidoglycan45 2911.5TLR4, TLR2, TLR1, IL10
30tarc4510.5IL5, IL10, IL13, IGHE
31polymyxin b4510.5IL10, TLR2, TLR4
32il 104510.5TLR4, TLR2, IL13, IL10, IL5
33imiquimod45 29 60 1113.5IL5, IL10, TLR1, TLR2, TLR4
34allergens4510.5IL5, IL10, IL13, IGHE, TLR4
35tacrolimus45 50 1112.4TLR4, TLR2, IL13, IL10, IL5
36budesonide45 50 1112.4IGHE, IL13, IL5
37prednisolone45 29 1112.4IGHE, IL13, IL10, IL5
38fluticasone propionate45 50 60 1113.4IL5, IL13, IGHE
39sb 20358045 6011.4TLR4, TLR2, IL13, IL10, IL5
40polysaccharide4510.3TLR4, TLR2, CHIT1, IGHE, IL13
41histamine45 29 2412.3TLR4, TLR2, IGHE, IL13, IL10, IL5
42vitamin d4510.3IL5, IL10, IGHE, TLR2, TLR4
43mannose4510.3IL13, CHIT1, TLR2, TLR4
44thyroxine45 2411.3IGHE, IL13, IL10, IL5
45pgd24510.3IL5, IL13, IGHE
46ionomycin4510.2TLR2, IL13, IL10, IL5
47poly(i-c)4510.1TLR4, TLR2, IL5
48diaminopimelic acid4510.0TLR2, TLR4
49dexamethasone45 50 29 1112.9TLR4, TLR2, IGHE, IL13, IL10, IL5
50vegf459.9IL5, IL10, IL13, IGHE, TLR2, TLR4

GO Terms for genes affiliated with Filariasis

Sources:
16Gene Ontology
See all sources

Cellular components related to Filariasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Toll-like receptor 1-Toll-like receptor 2 protein complexGO:03535410.0TLR2, TLR1
2integral to plasma membraneGO:0058879.9CD27, TNFRSF18, ICOS, TLR1, TLR2, TLR4
3external side of plasma membraneGO:0098979.8IL13, CD27, TNFRSF18, ICOS, TLR2, TLR4

Biological processes related to Filariasis according to GeneCards/GeneDecks:

(show all 20)
idNameGO IDScoreTop Affiliating Genes
1detection of triacyl bacterial lipopeptideGO:04249510.6TLR1, TLR2
2cellular response to triacyl bacterial lipopeptideGO:07172710.6TLR1, TLR2
3detection of diacyl bacterial lipopeptideGO:04249610.6TLR2, TLR1
4positive regulation of macrophage cytokine productionGO:06090710.6TLR2, TLR4
5cellular response to lipoteichoic acidGO:07122310.5TLR4, TLR2
6positive regulation of tumor necrosis factor biosynthetic processGO:04253510.5TLR1, TLR2, TLR4
7I-kappaB phosphorylationGO:00725210.5TLR4, TLR2, PRDX4
8regulation of cytokine secretionGO:05070710.5TLR4, TLR1
9positive regulation of MHC class II biosynthetic processGO:04534810.5TLR4, IL10
10positive regulation of B cell proliferationGO:03089010.5IL5, IL13, TLR4
11negative regulation of interleukin-17 productionGO:03270010.5TLR2, TLR4
12macrophage activationGO:04211610.4TLR1, TLR4
13positive regulation of nitric-oxide synthase biosynthetic processGO:05177010.4TLR2, TLR4
14inflammatory responseGO:00695410.3TLR2, TLR1, IL13, IL10, IL5
15MyD88-dependent toll-like receptor signaling pathwayGO:00275510.3TLR4, TLR2, TLR1
16positive regulation of chemokine productionGO:03272210.3TLR2, TLR4
17negative regulation of interleukin-12 productionGO:03269510.3IL10, TLR2
18T-helper 1 type immune responseGO:04208810.2TLR4, TLR1
19immune responseGO:00695510.1IL5, TLR4, TLR2, TLR1, ICOS, CHIT1
20negative regulation of growth of symbiont in hostGO:04413010.0IL10, TLR2

Molecular functions related to Filariasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1lipopolysaccharide receptor activityGO:00187510.3TLR2, TLR4
2transmembrane signaling receptor activityGO:0048889.8CD27, TLR1, TLR2, TLR4

Products for genes affiliated with Filariasis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Filariasis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet