MCID: FLR002
MIFTS: 61

Filariasis malady

Infectious diseases, Rare diseases categories

Summaries for Filariasis

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9Disease Ontology, 66Wikipedia, 34MalaCards
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Disease Ontology:9 A parasitic helminthiasis infectious disease that involves parasitic infection of the lymphatics and subcutaneous tissue by nematodes of the superfamily filarioidea.

MalaCards: Filariasis, also known as disease due to superfamily filarioidea, is related to malaria and schistosomiasis. An important gene associated with Filariasis is CHIT1 (chitinase 1 (chitotriosidase)), and among its related pathways are Selected targets of GCR alpha and MSP-RON Signaling. The compounds arabinogalactan and diaminopimelic acid have been mentioned in the context of this disorder. Affiliated tissues include testes, breast and t cells, and related mouse phenotypes are tumorigenesis and liver/biliary system.

Wikipedia:66 Filariasis (or philariasis) is a parasitic disease that is caused by thread-like roundworms belonging to... more...

Aliases & Classifications for Filariasis

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9Disease Ontology, 11DISEASES, 46Novoseek, 50Orphanet, 63UMLS, 59SNOMED-CT, 28ICD9CM, 36MeSH, 41NCIt, 27ICD10 via Orphanet, 37MESH via Orphanet, 64UMLS via Orphanet, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases, Rare diseases


Characteristics (Orphanet epidemiological data):

50
filariasis:
Inheritance: Sporadic; Age of onset: Variable


Aliases & Descriptions:

filariasis 9 11 46 50 63
disease due to superfamily filarioidea 9
filariasis, unspecified 9
unspecified filariasis 9
filariasis nos 9


External Ids:

Disease Ontology9 DOID:1080
ICD9CM28 125.9
MeSH36 D005368
NCIt41 C34611
ICD10 via Orphanet27 B72, B73, B74.0 B74.1, B74.2, B74.3, B74.4, B74.8, B74.9, more
MESH via Orphanet37 D005368
UMLS via Orphanet64 C0016085

Related Diseases for Filariasis

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18GeneCards, 19GeneDecks
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Diseases related to Filariasis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 123)
idRelated DiseaseScoreTop Affiliating Genes
1malaria30.9TLR2, CHIT1, IL10
2schistosomiasis30.6IL5, IL10, IL13
3pulmonary eosinophilia30.5IL5, IL13
4helminthiasis30.5IL5, IL13
5eosinophilia30.4IL13, IL10, IL5
6leprosy30.4TLR2
7gastritis29.9TLR2, TLR4
8leishmaniasis29.8IL13, IL10, IL5
9arthritis29.7TLR2, TLR4, IL10, IL13
10rheumatoid arthritis29.6TLR2, TLR4, IL10, IL13, CD27
11onchocerciasis10.6
12filarial elephantiasis10.6
13hydrocele10.5
14elephantiasis10.5
15loiasis10.4
16lymphedema10.4
17blindness10.2
18strongyloidiasis10.1
19mansonelliasis10.1
20dirofilariasis10.1
21endomyocardial fibrosis10.1
22eosinophilic fasciitis10.1IL5
23eosinophilic esophagitis10.1IL5
24meningitis10.1TLR2
25intestinal volvulus10.1TLR2, IL5
26lymphangiosarcoma10.1
27lymphangitis10.1
28toxocariasis10.1
29podoconiosis10.1
30amyloidosis10.1
31cervicitis10.1
32glomerulonephritis10.1
33scabies10.1
34aspergillosis10.1TLR2, TLR4
35colorectal cancer10.1TLR2, TLR4
36invasive aspergillosis10.1TLR2, TLR4
37pouchitis10.1TLR2, TLR4
38melioidosis10.1TLR2, TLR4
39neisseria meningitidis infection10.0TLR2, TLR4
40chorioamnionitis10.0TLR2, TLR4
41allergic conjunctivitis10.0IL5, IL13
42mastitis10.0TLR2, TLR4
43keratoconjunctivitis10.0IL5, IL13
44eosinophilic pneumonia10.0IL5, IL13
45asthma10.0IL5, IL13
46periodontitis10.0TLR2, TLR4
47allergic rhinitis10.0IL5, IL13
48food allergy10.0IL5, IL13
49vernal keratoconjunctivitis10.0IL13, IL5
50keratitis10.0TLR4, TLR2

Graphical network of the top 20 diseases related to Filariasis:



Diseases related to filariasis

Symptoms for Filariasis

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Drugs & Therapeutics for Filariasis

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

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Drug clinical trials:

Search ClinicalTrials for Filariasis

Search NIH Clinical Center for Filariasis

Search CenterWatch for Filariasis

Genetic Tests for Filariasis

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Anatomical Context for Filariasis

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34MalaCards
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MalaCards organs/tissues related to Filariasis:

34
Testes, Breast, T cells, B cells, Kidney, Endothelial

Animal Models for Filariasis or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Filariasis:

38 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.4IL10, IL5, TLR4, TLR2
2MP:00053708.4TLR2, TLR4, IL5, IL10
3MP:00053898.1IL13, IL10, IL5, TLR4
4MP:00107718.0TLR2, TLR4, IL10, IL13
5MP:00053887.8TLR2, TLR4, IL5, IL10, IL13
6MP:00053817.8TLR2, TLR4, IL5, IL10, IL13
7MP:00053787.6TLR2, TLR4, IL5, IL10, IL13
8MP:00053847.6CD27, IL13, IL10, TLR4, TLR2
9MP:00053767.3TLR2, TLR4, IL5, IL10, IL13
10MP:00053977.3TLR2, TLR4, IL5, IL10, IL13, CD27
11MP:00053877.0CD27, TLR2, TLR4, CHIT1, IL5, IL10

Publications for Filariasis

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53PubMed
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Articles related to Filariasis:

(show top 50)    (show all 575)
idTitleAuthorsYear
1
Ongoing surveillance for lymphatic filariasis in togo: assessment of alternatives and nationwide reassessment of transmission status. (24189363)
2014
2
Evaluation of Brugia malayi sheath protein (Shp-1) as a diagnostic antigen for human lymphatic filariasis. (24389369)
2013
3
Will mass drug administration eliminate lymphatic filariasis? Evidence from northern coastal Tanzania. (23014581)
2013
4
Insights into the pathogenesis of disease in human lymphatic filariasis. (24044755)
2013
5
Therapeutic efficacy of poly (lactic-co-glycolic acid) nanoparticles encapsulated ivermectin (nano-ivermectin) against brugian filariasis in experimental rodent model. (24366812)
2013
6
Impact of three rounds of mass drug administration on lymphatic filariasis in areas previously treated for onchocerciasis in Sierra Leone. (23785535)
2013
7
Urban lymphatic filariasis in the city of Tanga, Tanzania, after seven rounds of mass drug administration. (24135628)
2013
8
Malaria and lymphatic filariasis: the case for integrated vector management. (23084831)
2013
9
Long-lasting insecticidal nets are synergistic with mass drug administration for interruption of lymphatic filariasis transmission in Nigeria. (24205421)
2013
10
A comprehensive, model-based review of vaccine and repeat infection trials for filariasis. (23824365)
2013
11
Rapid assessment procedure for loiasis and mapping lymphatic filariasis: two perfect illustrations of "to be in English or not to be". (23272254)
2012
12
Cost-effective antigen testing for delimitation, monitoring and evaluation in bancroftian filariasis. (22290349)
2012
13
Evidence for stopping mass drug administration for lymphatic filariasis in some, but not all local government areas of Plateau and Nasarawa States, Nigeria. (22855758)
2012
14
Studies on Fungal Cultural Filtrates against Adult Culex quinquefasciatus (Diptera: Culicidae) a Vector of Filariasis. (22132305)
2011
15
Epidemiological assessment of continuing transmission of lymphatic filariasis in Samoa. (22325816)
2011
16
Progress toward elimination of lymphatic filariasis--Togo, 2000--2009. (21796097)
2011
17
Application of the Filariasis CELISA Antifilarial IgG(4) Antibody Assay in Surveillance in Lymphatic Filariasis Elimination Programmes in the South Pacific. (21961018)
2011
18
The "filarial dance" is not characteristic of filariasis: observations of "dancing megasperm" on high-resolution sonography in patients from nonendemic areas mimicking the filarial dance and a proposed mechanism for this phenomenon. (21795491)
2011
19
Zoonotic Brugia pahangi filariasis in a suburbia of Kuala Lumpur City, Malaysia. (20951228)
2011
20
A rare case of reversible acquired AA-type renal amyloidosis in a chronic filariasis patient receiving antifilarial therapy. (21519822)
2011
21
Lymphatic filariasis. (21972476)
2011
22
Antigen detection assay with parasite specific monoclonal antibodies for diagnosis of lymphatic filariasis. (21741373)
2011
23
Flubendazole: a candidate macrofilaricide for lymphatic filariasis and onchocerciasis field programs. (21609260)
2011
24
The impact of a national program to eliminate lymphatic filariasis in selected Myanmar immigrant communities in Bangkok and Ranong Province, Thailand. (22299429)
2011
25
Cutaneous angiosarcoma in chronic lymphedema: secondary to filariasis. (23024552)
2011
26
Applications of Self-Organising Map (SOM) for prioritisation of endemic zones of filariasis in Andhra Pradesh, India. (21954673)
2011
27
Screening mosquito house entry points as a potential method for integrated control of endophagic filariasis, arbovirus and malaria vectors. (20689815)
2010
28
Geographic and ecologic heterogeneity in elimination thresholds for the major vector-borne helminthic disease, lymphatic filariasis. (20236528)
2010
29
Association between Toll-like receptor 2 (TLR2) polymorphisms and asymptomatic bancroftian filariasis. (20549240)
2010
30
The sharp end - experiences from the Tanzanian programme for the elimination of lymphatic filariasis: notes from the end of the road. (19843398)
2009
31
A pilot program of mass surgery weeks for treatment of hydrocele due to lymphatic filariasis in central Nigeria. (19270297)
2009
32
Ten years of managing the clinical manifestations and disabilities of lymphatic filariasis. (19843392)
2009
33
Nigeria's war on terror: fighting dracunculiasis, onchocerciasis, lymphatic filariasis, and schistosomiasis at the grassroots. (19407107)
2009
34
Elimination of lymphatic filariasis in the Republic of Korea: an epidemiological survey of formerly endemic areas, 2002-2006. (19228352)
2009
35
Global programme to eliminate lymphatic filariasis. (18788146)
2008
36
Impact of seven rounds of mass administration of diethylcarbamazine and ivermectin on prevalence of chronic lymphatic filariasis in south India. (18346027)
2008
37
An unusual presentation of filariasis: a case report. (18499995)
2008
38
Eliminating lymphatic filariasis: a view from the field. (18579875)
2008
39
Pharmacovigilance through consumer feedback (reporting) in the mass treatment of lymphatic filariasis using diethylcarbamazine and albendazole in two districts of Sri Lanka. (18631319)
2008
40
National mass drug administration costs for lymphatic filariasis elimination. (17989784)
2007
41
Confirmation of elimination of lymphatic filariasis by an IgG4 enzyme-linked immunosorbent assay with urine samples in Yongjia, Zhejiang Province and Gaoan, Jiangxi Province, People's Republic of China. (17690407)
2007
42
Epidemiological modelling for monitoring and evaluation of lymphatic filariasis control. (18063097)
2007
43
A critical appraisal of molecular xenomonitoring as a tool for assessing progress toward elimination of Lymphatic Filariasis. (17978055)
2007
44
Effect of diethylcarbamazine on HIV load, CD4%, and CD4/CD8 ratio in HIV-infected adult Tanzanians with or without lymphatic filariasis: randomized double-blind and placebo-controlled cross-over trial. (17827369)
2007
45
Plasma vascular endothelial growth Factor-A (VEGF-A) and VEGF-A gene polymorphism are associated with hydrocele development in lymphatic filariasis. (17978056)
2007
46
Ocular filariasis due to Wuchereria bancrofti presenting as panuveitis: a case report. (14533034)
2003
47
Serum levels of endothelin-1 (ET-1), interleukin-2 (IL-2) and amino-terminal propeptide type III procollagen (PIII NP) in patients with acute and chronic filariasis. (12557940)
2001
48
Infectious diseases: filariasis, Malayan filariasis, loiasis (ioa ioa), Onchocerciasis (river blindness). (11930850)
2001
49
Renal disease in lymphatic filariasis: evidence for tubular and glomerular disorders at various stages of the infection. (9315046)
1997
50
Treatment of elephantiasis in a community with timorian filariasis. (3992641)
1985

Variations for Filariasis

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Expression for genes affiliated with Filariasis

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Filariasis

Search GEO for disease gene expression data for Filariasis.

Pathways for genes affiliated with Filariasis

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Sources:
51PathCards, 13EMD Millipore, 54QIAGEN, 31KEGG, 55R&D Systems, 61Thomson Reuters, 5Cell Signaling Technology, 39NCBI BioSystems Database, 58SinoBiological, 62Tocris Bioscience
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Pathways related to Filariasis according to GeneCards/GeneDecks:

(show all 33)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6IL5, TLR2
29.5TLR4, TLR2
39.5TLR4, TLR2
49.5TLR2, TLR4
5
Show member pathways
9.5TLR2, TLR4
6
Show member pathways
Transcription NF kB signaling pathway61
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response61
9.5TLR4, TLR2
7
Show member pathways
9.5TLR4, TLR2
89.5TLR4, TLR2
99.5TLR4, TLR2
109.4IL5, IL13
119.4IL5, IL13
129.2IL10, IL5
139.2IL10, IL5
149.1IL10, TLR4
159.1IL10, TLR4
16
Show member pathways
9.0CD27, TLR4, TLR2
17
Show member pathways
8.9TLR2, TLR4, IL13
188.7TLR2, TLR4, IL10
19
Show member pathways
Toll-like receptor signaling pathway39
Regulation of toll-like receptor signaling pathway39
8.7TLR2, TLR4, IL10
208.7IL10, TLR4, TLR2
21
Show member pathways
IL27-mediated signaling events39
8.7IL10, TLR4, TLR2
228.7TLR2, TLR4, IL10
238.6IL5, IL10, IL13
24
Show member pathways
8.6IL5, IL10, IL13
25
Show member pathways
8.6IL5, IL10, IL13
26
Show member pathways
Type III interferon signaling39
8.6IL5, IL10, IL13
278.6IL13, IL10, IL5
288.6IL13, IL10, IL5
29
Show member pathways
8.6IL13, IL10, IL5
30
Show member pathways
8.5TLR2, TLR4, IL5, IL13
31
Show member pathways
7.6TLR2, TLR4, IL5, IL10, IL13
32
Show member pathways
7.6IL13, IL10, IL5, TLR4, TLR2
33
Show member pathways
7.6TLR4, IL5, IL10, IL13, CD27

Compounds for genes affiliated with Filariasis

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Sources:
46Novoseek, 62Tocris Bioscience, 30IUPHAR, 12DrugBank, 52PharmGKB, 25HMDB
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Compounds related to Filariasis according to GeneCards/GeneDecks:

(show top 50)    (show all 112)
idCompoundScoreTop Affiliating Genes
1arabinogalactan469.8TLR2, TLR4
2diaminopimelic acid469.7TLR2, TLR4
3poly(i:c)629.6TLR4, TLR2
4pam3csk4629.6TLR4, TLR2
5pam2csk4629.5TLR4, TLR2
6p 277469.5TLR2, IL10
7poly(i-c)469.4IL5, TLR4, TLR2
8amphotericin b469.4TLR2, IL5, IL13
9anti-fungal469.4TLR4, IL5, TLR2
10loxoribine46 3010.4TLR2, TLR4
11omalizumab46 1210.1IL5, IL13
12glucuronoxylomannan469.1IL10, TLR2, TLR4
13polymyxin b469.1TLR2, TLR4, IL10
14glatiramer acetate46 1210.0IL13, IL10, IL5
15praziquantel46 1210.0IL13, IL5, IL10
16lipoteichoic acid469.0TLR2, TLR4, IL10
17as 10146 6210.0IL10, IL13, IL5
18il-12469.0IL5, IL10, IL13
19montelukast46 52 30 1212.0IL5, IL10, IL13
20gm-csf46 3010.0IL10, IL13, IL5
21leukotriene b446 62 2511.0TLR2, IL13, IL5
22salbutamol46 52 30 25 1213.0IL10, IL5, IL13
23peptidoglycan46 3010.0IL10, TLR4, TLR2
24rolipram46 62 3011.0IL13, IL5, IL10
25tarc468.9IL10, IL5, IL13
26mannose468.9TLR4, TLR2, IL13, CHIT1
27polysaccharide468.8TLR2, IL13, CHIT1, TLR4
28theophylline46 30 25 1211.8IL13, IL5, IL10
29thalidomide46 52 62 1211.8IL13, IL10, IL5
30ifn-alpha468.8TLR4, IL13, IL10
31imiquimod46 62 30 1211.7IL10, IL5, TLR4, TLR2
32polyinosinic-polycytidylic acid468.7TLR4, IL5, TLR2, IL10
33vitamin d468.6TLR2, TLR4, IL5, IL10
34ionomycin468.6IL10, IL13, TLR2, IL5
35allergens468.5TLR4, IL5, IL10, IL13
36ccl346 309.5IL13, IL10, TLR4, TLR2
37endotoxin468.4IL10, TLR2, IL13, TLR4
38calcitriol46 62 25 1211.4TLR2, IL10, TLR4, IL13
39ly294002468.4IL13, TLR4, IL10, IL5
40cysteine468.2IL13, TLR2, TLR4, IL5, CD27
41il 10468.1TLR4, IL10, TLR2, IL5, IL13
42tacrolimus46 52 1210.1TLR4, IL10, IL13, TLR2, IL5
43rantes468.1IL13, IL5, TLR4, TLR2, IL10
44sb 20358046 629.1TLR4, IL13, IL10, IL5, TLR2
45histamine46 30 2510.1TLR2, IL13, IL5, TLR4, IL10
46cyclosporin a46 30 6210.1IL10, IL13, IL5, TLR4, TLR2
47pge2468.1IL10, IL5, TLR4, TLR2, IL13
48cycloheximide468.1IL13, IL10, IL5, TLR2, TLR4
49dexamethasone46 52 30 1211.0TLR2, TLR4, IL5, IL10, IL13
50vegf468.0TLR2, IL5, TLR4, IL13, IL10

GO Terms for genes affiliated with Filariasis

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17Gene Ontology
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Cellular components related to Filariasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.2IL13, IL10, IL5, CHIT1
2external side of plasma membraneGO:0098978.1CD27, IL13, TLR4, TLR2

Biological processes related to Filariasis according to GeneCards/GeneDecks:

(show all 38)
idNameGO IDScoreTop Affiliating Genes
1cellular response to lipoteichoic acidGO:0712239.9TLR2, TLR4
2positive regulation of macrophage cytokine productionGO:0609079.9TLR2, TLR4
3negative regulation of interleukin-17 productionGO:0327009.9TLR4, TLR2
4positive regulation of tumor necrosis factor biosynthetic processGO:0425359.9TLR2, TLR4
5I-kappaB phosphorylationGO:0072529.9TLR4, TLR2
6positive regulation of nitric-oxide synthase biosynthetic processGO:0517709.9TLR4, TLR2
7positive regulation of chemokine productionGO:0327229.9TLR2, TLR4
8positive regulation of interleukin-10 productionGO:0327339.9TLR4, TLR2
9positive regulation of NF-kappaB import into nucleusGO:0423469.9TLR2, TLR4
10positive regulation of interleukin-8 productionGO:0327579.9TLR4, TLR2
11positive regulation of interferon-beta productionGO:0327289.8TLR2, TLR4
12positive regulation of interleukin-12 productionGO:0327359.8TLR4, TLR2
13lipopolysaccharide-mediated signaling pathwayGO:0316639.8TLR4, TLR2
14positive regulation of nitric oxide biosynthetic processGO:0454299.8TLR2, TLR4
15positive regulation of tumor necrosis factor productionGO:0327609.8TLR4, TLR2
16positive regulation of interleukin-6 productionGO:0327559.8TLR4, TLR2
17positive regulation of inflammatory responseGO:0507299.8TLR4, TLR2
18toll-like receptor TLR6:TLR2 signaling pathwayGO:0381249.7TLR2, TLR4
19positive regulation of JNK cascadeGO:0463309.7CD27, TLR4
20toll-like receptor TLR1:TLR2 signaling pathwayGO:0381239.6TLR2, TLR4
21negative regulation of interleukin-12 productionGO:0326959.6IL10, TLR2
22negative regulation of growth of symbiont in hostGO:0441309.6TLR2, IL10
23toll-like receptor 2 signaling pathwayGO:0341349.6TLR4, TLR2
24positive regulation of MHC class II biosynthetic processGO:0453489.5TLR4, IL10
25cellular response to mechanical stimulusGO:0712609.5IL13, TLR4
26positive regulation of cytokine secretionGO:0507159.5TLR2, IL10
27MyD88-dependent toll-like receptor signaling pathwayGO:0027559.5TLR4, TLR2
28toll-like receptor 4 signaling pathwayGO:0341429.5TLR4, TLR2
29negative regulation of interleukin-6 productionGO:0327159.5IL10, TLR4
30negative regulation of interferon-gamma productionGO:0326899.5TLR4, IL10
31response to insulinGO:0328689.4TLR2, IL10
32negative regulation of tumor necrosis factor productionGO:0327209.4TLR4, IL10
33positive regulation of B cell proliferationGO:0308909.3TLR4, IL5, IL13
34cellular response to lipopolysaccharideGO:0712229.2TLR4, IL10
35response to ethanolGO:0454719.2IL13, CD27
36positive regulation of sequence-specific DNA binding transcription factor activityGO:0510918.9IL10, IL5
37inflammatory responseGO:0069548.6TLR2, IL5, IL10, IL13
38immune responseGO:0069558.5IL13, IL5, CHIT1, TLR4, TLR2

Molecular functions related to Filariasis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1lipopolysaccharide receptor activityGO:0018759.4TLR4, TLR2
2transmembrane signaling receptor activityGO:0048888.7CD27, TLR4, TLR2
3cytokine activityGO:0051258.6IL13, IL10, IL5

Products for genes affiliated with Filariasis

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  • Antibodies
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Sources for Filariasis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet