Finnish Type Amyloidosis malady

Genetics Home Reference: Lattice corneal dystrophy type II is characterized by an accumulation of protein clumps called amyloid deposits in tissues throughout the body. The deposits frequently occur in blood vessel walls and basement membranes, which are thin, sheet-like structures that separate and support cells in many tissues. Amyloid deposits lead to characteristic signs and symptoms involving the eyes, nerves, and skin that worsen with age.¹⁷

MalaCards: Finnish Type Amyloidosis, also known as amyloidosis finnish type, is related to amyloidosis and hereditary amyloidosis. An important gene associated with Finnish Type Amyloidosis is GSN (gelsolin). The drugs acetylcysteine and colchicine and the compounds retinyl palmitate and thiamine have been mentioned in the context of this disorder. Affiliated tissues include skin.

Aliases & Descriptions:

finnish type amyloidosis 6 amyloidosis finnish type 30 16 amyloidosis 5 30 16 amyloid cranial neuropathy with lattice corneal dystrophy 30 lattice corneal dystrophy type ii finnish 30 familial amyloid polyneuropathy, type v 43

amyloidosis due to mutant gelsolin 30 amyloidosis, meretoja type 6 meretoja type amyloidosis 30 amyloidosis v 30 amyloidosis 43

Diseases related to finnish type amyloidosis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 162)

id	Related Disease	Score	Top Affiliating Genes
1	amyloidosis	37.5	TTR, GSN, APOE
2	hereditary amyloidosis	33.1	TTR, GSN
3	familial transthyretin amyloidosis	31.9	GSN, TTR
4	cerebritis	31.4	TTR, APOE, GSN
5	alzheimer's disease	30.7	APOE, TTR
6	lattice corneal dystrophy type ii	30.4	APOE, GSN, TTR
7	rheumatoid arthritis	30.1	GSN, TTR, APOE
8	polyneuropathy	29.1	GSN, APOE, TTR
9	corneal dystrophy	28.7	GSN, APOE
10	neuropathy	28.5	TTR, APOE, GSN
11	nephrotic syndrome	27.9	TTR, APOE, GSN
12	dementia	27.9	APOE, TTR, GSN
13	peripheral neuropathy	26.9	TTR, GSN, APOE
14	cerebral amyloid angiopathy	26.2	TTR, GSN, APOE
15	hearing loss	26.1	TTR, APOE, GSN
16	sensorineural hearing loss	25.8	GSN, APOE
17	headache	25.6	TTR, APOE
18	cutaneous t cell lymphoma	25.1	TTR, GSN
19	retinitis	24.1	GSN, TTR, APOE
20	endemic goiter	12.5	TTR, APOE
21	arteriosclerosis	12.5	APOE, TTR
22	primary open angle glaucoma	12.5	TTR, APOE
23	hyperhomocysteinemia	12.5	TTR, APOE
24	amyloid neuropathy	12.5	TTR, GSN
25	uremia	12.5	APOE, TTR
26	open-angle glaucoma	12.4	TTR, APOE
27	photosensitive trichothiodystrophy	12.4	TTR, APOE
28	focal segmental glomerulosclerosis	12.4	APOE, TTR
29	autonomic dysfunction	12.4	TTR, GSN
30	spinal cord injury	12.4	TTR, APOE
31	major depressive disorder	12.4	TTR, APOE
32	hyperthyroidism	12.3	APOE, TTR
33	fatty liver disease	12.2	APOE, TTR
34	cholestasis	12.1	APOE, TTR
35	acute pancreatitis	12.0	APOE, TTR
36	amyloid tumor	12.0	TTR, APOE, GSN
37	inclusion body myositis	11.9	APOE, GSN, TTR
38	myositis	11.9	TTR, GSN, APOE
39	noonan syndrome	11.9	GSN, APOE, TTR
40	myocardial infarction	11.9	GSN, APOE, TTR
41	adenoma	11.8	APOE, TTR, GSN
42	fibrosis	11.8	TTR, GSN, APOE
43	gonococcal synovitis	11.8	APOE, TTR, GSN
44	sepsis	11.7	TTR, GSN
45	transthyretin amyloidosis	9.9
46	al amyloidosis	9.3
47	familial mediterranean fever	9.0
48	hereditary cerebral hemorrhage with amyloidosis	8.7
49	primary cutaneous amyloidosis	8.6
50	cerebral hemorrhage	8.6

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 acetylcysteine, colchcine, colchicine

Genetic tests related to finnish type amyloidosis:

id	Genetic test	Affiliating Genes
1	Finnish Type Amyloidosis clinical/research	GSN

MalaCards organs/tissues related to finnish type amyloidosis:

²²

Genes related to finnish type amyloidosis according to GeneCards:

id	Symbol	Description	Score	GeneCards Section Context
1	GSN	gelsolin	11.0
2	TTR	transthyretin	11.0
3	APOE	apolipoprotein E	11.0

Compounds related to finnish type amyloidosis according to GeneDecks:

(show all 28)

id	Compound	Score	Top Affiliating Genes
1	retinyl palmitate32 18	10.5	APOE, TTR
2	thiamine32 9 18 9	12.5	APOE, TTR
3	guanidine32 9 18 9	12.5	APOE, TTR
4	vitamin b1232	9.5	APOE, TTR
5	betacarotene32	9.5	TTR, APOE
6	guanidine hydrochloride32	9.4	APOE, TTR
7	alpha tocopherol32	9.4	APOE, TTR
8	trifluoroethanol32 9 9	11.4	GSN, TTR
9	homocysteine32 18	10.4	TTR, APOE
10	adenine32 9 18 9	12.4	APOE, TTR
11	carbohydrates32	9.4	APOE, TTR
12	thyroxine32 18	10.3	APOE, TTR
13	hyaluronic acid32 18	10.3	TTR, APOE
14	folate32	9.3	APOE, TTR
15	valine32	9.2	APOE, TTR
16	aspirin32 34 18	11.1	TTR, APOE
17	phosphatidylserine32 9 9	11.1	GSN, TTR
18	polyacrylamide32	9.0	GSN, TTR
19	vitamin a32 9 18 9	12.0	APOE, TTR
20	thioflavin t32	8.9	GSN, APOE, TTR
21	sodium dodecylsulfate32	8.9	GSN, APOE, TTR
22	vitamin d32	8.9	TTR, APOE, GSN
23	aspartate32	8.9	TTR, APOE, GSN
24	testosterone32 9 18 9	11.8	GSN, APOE, TTR
25	guanine32 9 18 9	11.8	APOE, TTR
26	glutamate32	8.8	GSN, APOE, TTR
27	alanine32	8.8	TTR, APOE, GSN
28	cysteine32	8.8	GSN, APOE, TTR

Cellular components related to finnish type amyloidosis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	extracellular region	GO:005576	8.5	GSN, APOE, TTR
2	extracellular space	GO:005615	8.2	GSN, APOE, TTR