MCID: FLP002
MIFTS: 10

Floppy Infant Syndrome

Aliases & Classifications for Floppy Infant Syndrome

MalaCards integrated aliases for Floppy Infant Syndrome:

Name: Floppy Infant Syndrome 50

Summaries for Floppy Infant Syndrome

NINDS : 50 Hypotonia is a medical term used to describe decreased muscle tone.  Normally, even when relaxed, muscles have a very small amount of contraction that gives them a springy feel and provides some resistance to passive movement.  It is not the same as muscle weakness, although the two conditions can co-exist.  Muscle tone is regulated by signals that travel from the brain to the nerves and tell the muscles to contract.  Hypotonia can happen from damage to the brain, spinal cord, nerves, or muscles.  The damage can be the result of trauma, environmental factors, or genetic, muscle, or central nervous system disorders.  For example, it can be seen in Down syndrome, muscular dystrophy, cerebral palsy, Prader-Willi syndrome, myotonic dystrophy, and Tay-Sachs disease.  Sometimes it may not be possible to find what causes the hypotonia.  Infants with hypotonia have a floppy quality or “rag doll” appearance because their arms and legs hang by their sides and they have little or no head control.  Other symptoms of hypotonia include problems with mobility and posture, breathing and speech difficulties, ligament and joint laxity, and poor reflexes.  Hypotonia does not affect intellect.  The opposite of hypotonia is hypertonia.

MalaCards based summary : Floppy Infant Syndrome The drugs Oxytocin and Oxytocics have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and skeletal muscle.

Wikipedia : 72 Hypotonia, commonly known as floppy baby syndrome, is a state of low muscle tone (the amount of tension... more...

Related Diseases for Floppy Infant Syndrome

Symptoms & Phenotypes for Floppy Infant Syndrome

Drugs & Therapeutics for Floppy Infant Syndrome

Drugs for Floppy Infant Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Oxytocin Approved, Vet_approved Phase 1, Phase 2 50-56-6 53477758 439302
2 Oxytocics Phase 1, Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Evaluation of Tolerance, Suckling and Food Intake After Repeated Nasals Administrations of Oxytocin in PWS Infants Completed NCT02205034 Phase 1, Phase 2 oxytocin
2 Tolerance of Intranasal Administration of OT in Prader-Willi Newborn Babies Completed NCT01548521 Phase 1, Phase 2 Oxytocin
3 Myotubular Myopathy Event Study Completed NCT01840657

Search NIH Clinical Center for Floppy Infant Syndrome

Genetic Tests for Floppy Infant Syndrome

Anatomical Context for Floppy Infant Syndrome

MalaCards organs/tissues related to Floppy Infant Syndrome:

38
Brain, Spinal Cord, Skeletal Muscle

Publications for Floppy Infant Syndrome

Articles related to Floppy Infant Syndrome:

# Title Authors Year
1
Clinical and skeletal muscle biopsy characteristics of 25 patients with floppy infant syndrome. ( 23743156 )
2013
2
Floppy infant syndrome. ( 19078754 )
2004
3
Ketamine monoanaesthesia for diagnostic muscle biopsy in neuromuscular disorders in infancy and childhood: floppy infant syndrome. ( 2340618 )
1990
4
The floppy infant syndrome. ( 2595188 )
1989
5
A clinico-pathological study of the floppy infant syndrome. ( 659092 )
1978
6
Floppy-infant syndrome and maternal diazepam and/or nitrazepam. ( 72227 )
1977
7
Floppy-infant syndrome: Is oxazepam the answer? ( 73027 )
1977
8
Organic aciduria. Treatable cause of floppy infant syndrome. ( 962376 )
1976
9
The floppy infant syndrome in muscular glycogenosis. ( 4263587 )
1972

Variations for Floppy Infant Syndrome

Expression for Floppy Infant Syndrome

Search GEO for disease gene expression data for Floppy Infant Syndrome.

Pathways for Floppy Infant Syndrome

GO Terms for Floppy Infant Syndrome

Sources for Floppy Infant Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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