MCID: FCL022
MIFTS: 44

Focal Dystonia malady

Categories: Rare diseases, Neuronal diseases, Blood diseases

Aliases & Classifications for Focal Dystonia

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Aliases & Descriptions for Focal Dystonia:

Name: Focal Dystonia 11 48 27 50 13 68
Ftsd 48 25
Dystonia, Focal, Task-Specific 68
Focal Task Specific Dystonia 48
Task-Specific Focal Dystonia 25
 
Focal Task-Specific Dystonia 25
Task-Specific Dystonia 25
Occupational Dystonia 25
Focal Hand Dystonia 25
Occupational Cramp 25

Classifications:



External Ids:

Disease Ontology11 DOID:0050836

Summaries for Focal Dystonia

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NIH Rare Diseases:48 Focal dystonia is a movement disorder that is localized to a specific part of the body. The dystonias are a group of movement problems characterized by involuntary, sustained muscle contractions, tremors, and other uncontrolled movements. Focal task-specific dystonia, or FTSD, interferes with the performance of particular tasks, such as writing, playing a musical instrument, or participating in a sport. Additionally, FTSD has been reported in tailors, shoemakers, hair stylists, and people who frequently type or use a computer mouse. While the abnormal movements associated with focal dystonia are usually painless, they can cause high levels of anxiety. The causes of focal dystonia are unknown, although the disorder likely results from a combination of genetic and environmental factors. It is possible that the different forms of FTSD have different underlying causes. Researchers have found that at least some cases are related to malfunction of the basal ganglia, which are structures deep within the brain that help start and control movement. Most cases of focal dystonia are sporadic, which means they occur in people with no history of the condition in their family. However, at least 10 percent of affected individuals have a family history which seems to follow an autosomal dominant pattern of inheritance. Last updated: 9/11/2013

MalaCards based summary: Focal Dystonia, also known as ftsd, is related to oromandibular dystonia and cranio-facial dystonia, and has symptoms including dystonia, dystonia, paroxysmal and dystonia, limb. An important gene associated with Focal Dystonia is TOR1A (Torsin Family 1 Member A), and among its related pathways is Dopamine-DARPP32 Feedback onto cAMP Pathway. Affiliated tissues include brain, cortex and spinal cord, and related mouse phenotype behavior/neurological.

Disease Ontology:11 A dystonia that is localized to a specific part of the body.

Genetics Home Reference:25 Task-specific focal dystonia is a movement disorder that interferes with the performance of particular tasks, such as writing, playing a musical instrument, or participating in a sport. Dystonias are a group of movement problems characterized by involuntary, sustained muscle contractions, tremors, and other uncontrolled movements. The term "focal" refers to a type of dystonia that affects a single part of the body, such as the hand or jaw.

Wikipedia:71 Focal dystonia is a neurological condition that affects a muscle or group of muscles in a specific part... more...

Related Diseases for Focal Dystonia

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Diseases related to Focal Dystonia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 74)
idRelated DiseaseScoreTop Affiliating Genes
1oromandibular dystonia31.6DRD5, THAP1, TOR1A
2cranio-facial dystonia31.1GCH1, THAP1, TOR1A
3cervical dystonia30.7CIZ1, GCH1, SGCE, THAP1, TOR1A
4oculogyric crisis29.5CIZ1, DRD5, GCH1, GNAL, HLA-DRB1, TOR1A
5dystonia 2511.5
6blepharospasm11.2
7blepharospasm, primary benign11.0
8dystonia 2411.0
9partington syndrome11.0
10dystonia-1, torsion10.8
11focal hand dystonia10.8
12spasmodic dystonia10.8
13dystonia10.8
14limbic encephalitis10.4TIMM8A, TOR1A
15aberrant subclavian artery10.3THAP1, TOR1A
16x-linked dystonia-parkinsonism/lubag10.3THAP1, TOR1A
17charcot-marie-tooth disease, x-linked recessive, 510.2ANO3, TIMM8A
18thiamine metabolism dysfunction syndrome 210.2GCH1, TOR1A
19hemifacial spasm10.0
20intermittent explosive disorder9.9DRD2, DRD5
21acinar cell carcinoma9.9DRD2, DRD5
22miller fisher syndrome9.9SGCE, TBP
23ataxia9.9
24hemidystonia9.8ANO3, GNAL, THAP1, TOR1A
25irritant dermatitis9.8DRD2, DRD5
26cervicitis9.8
27cerebritis9.8
28tremor9.8
29multifocal dystonia9.8DRD2, THAP1, TOR1A
30long qt syndrome-119.8DRD2, SGCE, TOR1A
31osteogenesis imperfecta, type ix9.7DRD2, DRD5, SGCE
32cerebellar ataxia9.6
33spinocerebellar ataxia 179.6
34obsessive-compulsive disorder9.6
35wilson disease9.6
36neurofibromatosis, type 19.6
37creutzfeldt-jakob disease9.6
38mohr-tranebjaerg syndrome9.6
39brain injury9.6
40spinal stenosis9.6
41traumatic brain injury9.6
42restless legs syndrome9.6
43vitamin b12 deficiency9.6
44scoliosis9.6
45idiopathic scoliosis9.6
46siderosis9.6
47epilepsy9.6
48focal epilepsy9.6
49kallmann syndrome9.6
50ulnar neuropathy9.6

Graphical network of the top 20 diseases related to Focal Dystonia:



Diseases related to focal dystonia

Symptoms & Phenotypes for Focal Dystonia

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UMLS symptoms related to Focal Dystonia:


dystonia, dystonia, paroxysmal, dystonia, limb

MGI Mouse Phenotypes related to Focal Dystonia according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053867.6CIZ1, DRD2, DRD5, GNAL, SGCE, TBP

Drugs & Therapeutics for Focal Dystonia

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Drugs for Focal Dystonia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 41)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
AcetylcholineapprovedPhase 4, Phase 3, Phase 2, Phase 177651-84-3187
Synonyms:
ACh
Acetyl choline ion
Acetylcholine Chloride
Acetylcholine cation
 
Acetylcholinium: acetyl-Choline
Choline acetate
Choline acetate (ester)
O-Acetylcholine
acetylcholine chloride
2
RopivacaineapprovedPhase 474184057-95-471273, 175805
Synonyms:
(2S)-N-(2,6-dimethylphenyl)-1-propylpiperidine-2-carboxamide
(2S)-N-(2,6-dimethylphenyl)-1-propylpiperidine-2-carboxamide hydrochloride
(S)-(−)-1-propyl-2',6'-pipecoloxylidide
(S)-ropivacaine
84057-95-4
98717-15-8
AC1L41QM
AC1L41QN
BIDD:GT0203
C07532
C17H26N2O.HCl
CHEBI:8890
CHEMBL1077896
CID175804
CID175805
CPD000469137
D08490
I14-176
L-N-n-propylpipecolic acid-2,6-xylidide
LS-113954
 
MLS001401363
MolPort-003-983-292
NCGC00164597-01
Naropin
Naropin (TN)
ROPIVACAINE HCl
Ropivacaina
Ropivacaina [INN-Spanish]
Ropivacaina [Spanish]
Ropivacaine
Ropivacaine [INN]
Ropivacaine hydrochloride
Ropivacaine monohydrochloride
Ropivacainum
Ropivacainum [INN-Latin]
S-Ropivacaine
SAM001246524
SMR000469137
ST51051452
ropivacaine monohydrochloride,
ropivacaine monohydrochloride, (S)-isomer
3
IbuprofenapprovedPhase 450115687-27-13672
Synonyms:
(+-)-2-(P-Isobutylphenyl)propionic acid
(+-)-Ibuprofen
(+-)-P-Isobutylhydratropic acid
(+-)-alpha-Methyl-4-(2-methylpropyl)benzeneacetic acid
(4-Isobutylphenyl)-alpha-methylacetic acid
(RS)-ibuprofen
139466-08-3
15687-27-1
2-(4-Isobutylphenyl)propanoic acid
4-Isobutylhydratropic acid
58560-75-1
AC-11312
AC1L1GGE
AC1Q1P84
AC1Q1P85
ACHES-N-PAIN
ARONIS23835
Act-3
Actiprofen
Adex 200
Adran
Advil
Advil (TN)
Advil Liqui-Gels
Ak+C2278tren
Alaxan
Algofen
Am-Fam 400
Amelior
Amersol
Amibufen
Anafen
Anco
Andran
Anflagen
Antagil
Antalfene
Antarene
Antiflam
Apo-Ibuprofen
Apsifen
Apsifen-F
Artofen
Artril
Artril 300
BB_SC-1358
BIDD:GT0050
BRN 2049713
Balkaprofen
Betaprofen
Bloom
Bluton
Brofen
Brufanic
Brufen
Brufen 400
Bruflam
Brufort
Buburone
Bufeno
Bufigen
Bukrefen
Bupron
Buracaps
Burana
Butylenin
C01588
C13H18O2
CCRIS 3223
CHEBI:5855
CHEMBL521
CID3672
CPD000058184
Cap-Profen
Carol
Cesra
Children's Advil
Children's Elixsure
Children's Ibuprofen
Children's Motrin
Citalgan
Cobo
Codral
Combiflam
Cunil
D00126
D007052
DB01050
DOLO PUREN
Daiprophen
Dalsy
Dansida
Deep Relief
Dentigoa
Dibufen
Dignoflex
Dolgin
Dolgirid
Dolgit
Dolibu
Dolmaral
Dolo-Dolgit
Dolo-dolgit
Dolocyl
Dolofen
Dolofen-F
Dolofin
Dolofort
Dologel
Dolomax
Doloren
Dolormin
Doltibil
Dolven
Donjust B
Dorival
Drin
Duafen
Duobrus
Dura-Ibu
Duralbuprofen
Dysdolen
EU-0100691
Easifon
Ebufac
Emflam
Emflam-200
Emodin
Epobron
Eputex
Ergix
Esprenit
Exneural
Faspic
Femadon
Femafen
Femapirin
Femidol
Fenbid
Fenbid Spansule
Fendol
Fenspan
Fibraflex
Gelufene
Gofen
Grefen
Gynofug
HMS1920F15
HMS2089P05
HMS2091N03
HMS502M09
HSDB 3099
Haltran
I 4883
I01-7039
I0415
I4883_SIGMA
I7905_SIAL
IB-100
IDI1_000887
IP 82
IP-82
IP82
Ibol
Ibren
Ibu
Ibu-Attritin
Ibu-Slo
Ibu-Tab
Ibu-Tab 200
Ibu-attritin
Ibu-slo
Ibu-slow
Ibubest
Ibubeta
Ibucasen
Ibudol
 
Ibudolor
Ibufen
Ibuflamar
Ibufug
Ibugel
Ibugen
Ibugesic
Ibuhexal
Ibulagic
Ibular
Ibulav
Ibuleve
Ibulgan
Ibumed
Ibumerck
Ibumetin
Ibupirac
Ibuprin
Ibuprocin
Ibuprofen
Ibuprofene
Ibuprofeno
Ibuprofenum
Ibuprohm
Ibuprophen
Ibusal
Ibutid
Ifen
Inabrin
Inflam
Inoven
Ipren
Irfen
Isodol
Jenaprofen
Junifen
Junior Strength Advil
Junior Strength Ibuprofen
Junior Strength Motrin
KBio1_000887
KBio2_001329
KBio2_003897
KBio2_006465
KBio3_001390
Kesan
Kratalgin
LS-7454
Lamidon
Lebrufen
Librofem
Lidifen
Liptan
Lopane
MLS000069733
MLS001146965
Malafene
Manypren
Medipren
Melfen
Mensoton
Midol
Midol 200
Moment
Motrin
Motrin (TN)
Motrin IB
Mynosedin
NCI60_002065
NINDS_000887
NSC 256857
NSC256857
Nagifen-D
Napacetin
Narfen
Neo-Helvagit
Neo-Mindol
NeoProfen
Neobrufen
Nerofen
Noalgil
Nobafon
Nobfelon
Nobfen
Nobgen
Noritis
Norton
Novadol
Novo-Profen
Novogent
Novogent N
Novoprofen
Nuprilan
Nuprin
Nurofen
Optifen
Opturem
Oralfene
Ostarin
Ostofen
Ozonol
P-Isobutylhydratropic Acid
Paduden
Panafen
Pantrop
Para-Isobutylhydratropic Acid
Paxofen
Pedia-Profen
PediaProfen
Pediaprofen
Pediatric Advil
Perofen
Proartinal
Profen
Proflex
Provon
Quadrax
R.D. 13621
RD 13621
Rafen
Ranofen
Rebugen
Relcofen
Rhinadvil
Rofen
Roidenin
Rufen
Rufin
Rupan
SAM002264619
SMR000058184
SPBio_000178
STK177358
Sadefen
Salivia
Salprofen
Seclodin
Sednafen
Seklodin
Seskafen
Siyafen
Solpaflex
Solufen
Stelar
Sugafen
Suprafen
Suspren
Syntofene
TL8001184
Tab-Profen
Tabalon
Tabalon 400
Tatanal
Tempil
Tofen
Togal N
Tonal
Trendar
U 18573
U-18,573
U-18573
UCB 79171
Unipron
Upfen
Uprofen
Urem
VUFB 9649
Zafen
Zofen
alpha-(4-Isobutylphenyl)propionate
alpha-(4-Isobutylphenyl)propionic acid
alpha-(P-Isobutylphenyl)propionic acid
alpha-p-Isobutylphenylpropionate
alpha-p-Isobutylphenylpropionic acid
ibuprofen
p-Isobutyl-2-phenylpropionate
p-Isobutyl-2-phenylpropionic acid
p-Isobutylhydratropate
p-Isobutylhydratropic acid
4
Fentanylapproved, illicit, investigational, vet_approvedPhase 4773437-38-73345
Synonyms:
1-Phenethyl-4-(N-phenylpropionamido)piperidine
1-Phenethyl-4-N-propionylanilinopiperidine
1-phenethyl-4-N-propionylanilinopiperidine
437-38-7
5-22-08-00049 (Beilstein Handbook Reference)
80832-90-2
990-73-8 (citrate)
AC1L1FQ2
Actiq
BIDD:GT0555
BRN 0494484
CHEBI:119915
CHEMBL596
CID3345
D00320
DB00813
Duragesic
Duragesic (TN)
Duragesic-100
Duragesic-12
Duragesic-25
Duragesic-50
Duragesic-75
Durogesic
EINECS 207-113-6
Fentanest
Fentanil
Fentanil [DCIT]
Fentanila
Fentanila [INN-Spanish]
Fentanilo
Fentanyl
Fentanyl (JAN/USAN/INN)
Fentanyl CII
Fentanyl [INN:BAN]
Fentanyl citrate
Fentanyl-100
Fentanyl-12
Fentanyl-25
 
Fentanyl-50
Fentanyl-75
Fentanylum
Fentanylum [INN-Latin]
HSDB 3329
IONSYS
JNS020QD
L001275
LS-124439
Matrifen
MolPort-003-847-369
N-(1-Phenethyl-4-piperidinyl)-N-phenylpropionamide
N-(1-Phenethyl-4-piperidyl)propionanilide
N-(1-Phenethyl-piperidin-4-yl)-N-phenyl-propionamide
N-(1-Phenethylpiperidin-4-yl)-N-phenylpropionamide
N-(1-phenethyl-4-piperidinyl)-N-phenylpropionamide
N-(1-phenethyl-4-piperidyl)propionanilide
N-(1-phenethylpiperidin-4-yl)-N-phenylpropanamide
N-(1-phenethylpiperidin-4-yl)-N-phenylpropionamide
N-Phenethyl-4-(N-propionylanilino)piperidine
N-Phenyl-N-(1-(2-phenylethyl)-4-piperidinyl)propanamide
N-phenethyl-4-(N-propionylanilino)piperidine
N-phenyl-N-(1-(2-phenylethyl)-4-piperidinyl)propanamide
N-phenyl-N-[1-(2-phenylethyl)piperidin-4-yl]propanamide
NCGC00168252-01
Nasalfent
Oprea1_152073
Oprea1_207148
PDSP1_000860
PDSP2_000846
Pentanyl
Phentanyl
Propanamide, N-phenyl-N-(1-(2-phenylethyl)-4-piperidinyl)- (9CI)
R 4263
Rapinyl
Sentonil
Sublimase
Sublimaze
UNII-UF599785JZ
fentanyl
5Peripheral Nervous System AgentsPhase 4, Phase 3, Phase 222776
6Neurotransmitter AgentsPhase 4, Phase 3, Phase 2, Phase 117734
7abobotulinumtoxinAPhase 4, Phase 3, Phase 2626
8rimabotulinumtoxinBPhase 417
9onabotulinumtoxinAPhase 4, Phase 3, Phase 2626
10Botulinum ToxinsPhase 4, Phase 3, Phase 2, Phase 1669
11Botulinum Toxins, Type APhase 4, Phase 3, Phase 2630
12Cholinergic AgentsPhase 4, Phase 3, Phase 2, Phase 13846
13Neuromuscular AgentsPhase 4, Phase 3, Phase 21129
14incobotulinumtoxinAPhase 4, Phase 3, Phase 2635
15Anti-Inflammatory Agents, Non-SteroidalPhase 44295
16Central Nervous System DepressantsPhase 412806
17Cyclooxygenase InhibitorsPhase 42778
18NarcoticsPhase 43486
19Antirheumatic AgentsPhase 410627
20Analgesics, Non-NarcoticPhase 46260
21Adjuvants, AnesthesiaPhase 41588
22Anti-Inflammatory AgentsPhase 410355
23Analgesics, OpioidPhase 43091
24AnalgesicsPhase 411287
25Anesthetics, GeneralPhase 42787
26Anesthetics, IntravenousPhase 42406
27AnestheticsPhase 49001
28
MexiletineapprovedPhase 22031828-71-44178
Synonyms:
(+-)-1-(2,6-Dimethylphenoxy)propan-2-amine
(+-)-1-(2,6-dimethylphenoxy)propan-2-amine
(2RS)-1-(2,6-dimethylphenoxy)-2-aminopropane
1-(2',6'-Dimethylphenoxy)-2-aminopropane
1-(2,6-Dimethylphenoxy)-2-propanamine
1-(2,6-dimethylphenoxy)propan-2-amine
1-Methyl-2-(2,6-xylyloxy)ethanamine
1-Methyl-2-(2,6-xylyloxy)ethylamine
1-methyl-2-(2,6-xylyloxy)ethanamine
2-(2-Aminopropoxy)-1,3-DiMethyl-Benzene Hydrochloride
2-(2-aminopropoxy)-1,3-dimethylbenzene
31828-71-4
5370-01-4 (hydrochloride)
AB00053683
AC1L1HL7
AC1Q2BC5
AC1Q2BC6
BPBio1_000026
BRD-A64092382-003-04-3
BRN 2092205
BSPBio_000022
BSPBio_002254
C07220
CHEBI:115958
CHEBI:6916
CHEMBL558
CID4178
D08215
DB00379
DivK1c_000834
EINECS 250-825-7
I01-6374
IDI1_000834
KBio1_000834
KBio2_002082
KBio2_004650
 
KBio2_007218
KBio3_001474
KBioGR_001270
KBioSS_002082
KO-1173
KO1173
KOE-1173
LS-68257
Lopac0_000784
Mexiletene
Mexiletina
Mexiletina [INN-Spanish]
Mexiletine
Mexiletine (INN)
Mexiletine HCL
Mexiletine [INN:BAN]
Mexiletinum
Mexiletinum [INN-Latin]
Mexilitine
Mexilétine
Mexitil
Mexityl
MolPort-001-790-944
NCGC00015659-04
NCGC00162253-01
NCGC00162253-02
NINDS_000834
Prestwick0_000241
Prestwick1_000241
Prestwick2_000241
Prestwick3_000241
SBB070242
SPBio_002241
Spectrum3_000727
Spectrum4_000795
Spectrum5_001279
Spectrum_001602
UNII-1U511HHV4Z
29
AmlodipineapprovedPhase 248688150-42-92162
Synonyms:
()-Amlodipine
(RS)-3-ethyl 5-methyl 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyridine
2-[(2-Aminoethoxy)methyl]-4-(2-chlorophenyl)
3,5-Pyridinedicarboxylic acid, 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-ethyl 5-methyl ester
3,5-Pyridinedicarboxylic acid, 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-ethyl 5-methyl ester
3-Ethyl 5-methylester, (±)-2-[(2-aminoethoxy)methyl]-4-(o-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate
3-Ethyl-5-methyl ( -)-2-((2-aminoethoxy)methyl)-4-(2-chlorphenyl)-1,4-dihydro-6-methyl-3,5-pyridindicarboxylat
3-Ethyl-5-methyl ( -)-2-((2-aminoethoxymethyl)-4-(o-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate
3-Ethyl-5-methyl (+-)-2-(2-aminoethoxymethyl)-4-(O-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate
3-Ethyl-5-methyl (+-)-2-(2-aminoethoxymethyl)-4-(o-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate
3-Ethyl-5-methyl (.+/-.)-2-[(2-aminoethoxy)methyl]-4-(o-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate
3-O-ethyl 5-O-methyl 2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
3-ethyl 5-methyl 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
3-ethyl 5-methyl 2-{[(2-aminoethyl)oxy]methyl}-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
88150-42-9
88150-47-4 (maleate (1:1))
AC-4535
AC1L1D26
AC1Q32ZS
AMLODIPINE BASE
AMVAZ
Ambap88150-42-9
Amlocard
Amlodipine
Amlodipine (INN)
Amlodipine Benzenesulfonate
Amlodipine Besilate
Amlodipine Besylate
Amlodipine Free Base
Amlodipine [INN:BAN]
Amlodipine besilate
Amlodipine besylate
Amlodipine free base
Amlodipino
Amlodipino [Spanish]
Amlodipinum
Amlodipinum [Latin]
Amlodis
Amlopres
Amlor
 
Amvaz
BIDD:GT0810
BRD-A22032524-074-02-4
BRD-A22032524-074-03-2
BSPBio_002727
C06825
CHEBI:2668
CHEMBL1491
CID2162
CPD000469198
Coroval
D07450
DB00381
HMS2052N03
HMS2089H07
I14-0798
Intervask
Istin
KBio3_001947
KBioGR_001643
LS-131183
Lipinox
Lotrel
MLS001401409
MolPort-001-792-963
NCGC00165957-01
NCGC00165957-02
NCGC00165957-03
Norvasc
Norvasc (TN)
Pelmec
R,S)-Amlodipine
Racemic Amlodipine
SAM001246705
SMR000469198
SPBio_000351
Spectrum2_000486
Spectrum3_001004
Spectrum4_001132
Spectrum5_001550
UK-4834011
UNII-1J444QC288
amlodipine
30Diuretics, Potassium SparingPhase 21827
31Anti-Arrhythmia AgentsPhase 22969
32Sodium Channel BlockersPhase 21515
33calcium channel blockersPhase 21940
34Vasodilator AgentsPhase 23438
35Antihypertensive AgentsPhase 24095
36Calcium, DietaryPhase 25525
37
Dopamineapproved375951-61-6, 62-31-7681
Synonyms:
(3H)-Dopamine
.Beta.-(3,4-Dihydroxyphenyl)ethylamine hydrochloride
.alpha.-(3,4-Dihydroxyphenyl)-.beta.-aminoethane
1,2-Benzenediol, 4-(2-aminoethyl)- (9CI)
1,2-Benzenediol, 4-(2-aminoethyl)-, hydrochloride
1,2-Benzenediol, 4-(2-aminoethyl)-, labeled with tritium
153C5321-5FEE-4B0B-8925-F388F0EEEBD1
2-(3,4-Dihydroxyphenyl)ethylamine
2-(3,4-dihydroxyphenyl)ethylamine
2-benzenediol
3,4-Dihydroxyphenethylamine
3,4-Dihydroxyphenethylamine hydrochloride
3,4-Dihydroxyphenylethylamine
3,4-dihydroxyphenethylamine
3-Hydroxtyramine
3-Hydroxytyramine
3-Hydroxytyramine Hydrobromide
3-Hydroxytyramine hydrochloride
4-(2-Aminoethyl)-1,
4-(2-Aminoethyl)-1,2-benzenediol
4-(2-Aminoethyl)-1,2-bezenediol
4-(2-Aminoethyl)-Pyrocatechol
4-(2-Aminoethyl)benzene-1,2-diol
4-(2-Aminoethyl)catechol
4-(2-Aminoethyl)pyrocatechol
4-(2-Aminoethyl)pyrocatechol hydrochloride
4-(2-aminoethyl)-pyrocatechol
50444-17-2
51-61-6
62-31-7 (HYDROCHLORIDE)
AC1L19S5
AC1Q54AX
AC1Q54AY
AKOS003790978
ASL 279
BIDD:ER0506
BPBio1_001123
BSPBio_001932
Biomol-NT_000001
C03758
CHEBI:18243
CHEMBL59
CID681
D07870
DB00988
Deoxyepinephrine
DivK1c_000780
Dopamin
Dopamina
Dopamina [INN-Spanish]
Dopamine
Dopamine (INN)
Dopamine (USAN)(*hydrochloride*)
Dopamine [INN:BAN]
Dopaminum
Dopaminum [INN-Latin]
Dopastat
Dophamine
Dynatra
EINECS 200-110-0
HSDB 3068
Hydroxytyramin
Hydroxytyramine
IDI1_000780
IP 498
Intropin
Intropin [*hydrochloride*]
KBio1_000780
 
KBio2_001492
KBio2_002388
KBio2_002484
KBio2_004060
KBio2_004956
KBio2_005052
KBio2_006628
KBio2_007524
KBio2_007620
KBio3_001152
KBio3_002867
KBio3_002962
KBioGR_001129
KBioGR_002388
KBioGR_002484
KBioSS_001492
KBioSS_002393
KBioSS_002491
KW-3-060
L-DOPAMINE
L000232
LDP
LS-159
Lopac-H-8502
Lopac0_000586
Medopa (TN)
MolPort-001-641-000
NCGC00015519-01
NCGC00015519-08
NCGC00096050-01
NCGC00096050-02
NCGC00096050-03
NCGC00096050-04
NCGC00096050-05
NINDS_000780
NSC 173182
NSC169105
NSC173182
Oprea1_088821
Oxytyramine
Pyrocatechol, 4-(2-aminoethyl)- (8CI)
Pyrocatechol, 4-(2-aminoethyl)-, hydrochloride
Revimine
Revivan
SPBio_001205
SPECTRUM1505155
ST048774
STK301601
Spectrum2_001023
Spectrum3_000406
Spectrum4_000525
Spectrum5_000945
Spectrum_001012
UNII-VTD58H1Z2X
UPCMLD0ENAT5885989:001
a-(3,4-Dihydroxyphenyl)-b-aminoethane
alpha-(3,4-Dihydroxyphenyl)-beta-aminoethane
cMAP_000036
cMAP_000065
dopamine
hydroxytyramine
intropin
m-Hydroxytyramine hydrochloride
nchembio.105-comp9
nchembio.107-comp4
nchembio.284-comp1
nchembio.78-comp16
nchembio.89-comp3
nchembio705-8
nchembio801-comp8
38
Flumazenilapproved2678755-81-43373
Synonyms:
4H-Imidazo(1,5-a)(1,4)benzodiazepine-3-carboxylic acid, 8-fluoro-5,6-dihydro-5-methyl-6-oxo-, ethyl ester
78755-81-4
8-Fluoro-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid ethyl ester
AC-6846
AC1L1FSE
AC1Q33UE
Anexate
BIDD:GT0766
BPBio1_001190
BRD-K98769987-001-01-3
BRN 4763661
Biomol-NT_000285
C07825
C15H14FN3O3
CHEBI:5103
CHEMBL407
CID3373
CPD000058450
D005442
D00697
DB01205
EU-0100506
Ethyl 8-fluoro-5,6-dihydro-5-methyl-6-oxo-4H-imidazo(1,5-a)(1,4)benzodiazepine-3-carboxylate
Ethyl 8-fluoro-5-methyl-5,6-dihydro-6-oxo-4H-imidazo(1,5-a)(1,4)benzodiazepine-3-carboxylate
Ethyl 8-fluoro-5-methyl-6-oxo-5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate
F 6300
F6300_SIGMA
Flumazenil (JAN/USP/INN)
Flumazenil [USAN:BAN:INN]
Flumazenilo
Flumazenilo [Spanish]
Flumazenilum
Flumazenilum [Latin]
Flumazepil
Flumazepil, Ro 15-1788, Anexate, Lanexat, Mazicon, Roma,Flumazenil
HMS2051D17
HMS2089B15
Hoffman La Roche Brand of Flumazenil
Hoffman-La Roche Brand of Flumazenil
I01-0379
LS-77778
 
Lanexat
Lopac-F-6300
Lopac0_000506
MLS000028850
MLS000759529
MLS001076354
Mazicon
MolPort-003-666-855
NCGC00015439-01
NCGC00015439-03
NCGC00015439-07
NCGC00025116-01
NCGC00025116-02
NCGC00025116-03
NCGC00025116-04
NCGC00025116-05
PDSP1_001778
PDSP2_001761
RO-151788
Ro 15 1788
Ro 15-1788
Ro 151788
Ro-15-1788
Ro-?15-1788
Ro15-1788
Roche Brand of Flumazenil
Romazicon
Romazicon (TN)
S1332_Selleck
SAM001246763
SBB063113
SMR000058450
TL8005362
Tocris-1328
UNII-40P7XK9392
UPCMLD-DP137
UPCMLD-DP137:001
ZINC00001464
[3H]Ro15-1788
ethyl 8-fluoro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate
flumazenil
nchembio747-comp37
39Protective Agents7190
40Autonomic Agents9774
41Dopamine Agents3759

Interventional clinical trials:

(show top 50)    (show all 61)
idNameStatusNCT IDPhase
1Quantifying Musical Performance After Treatment With Myobloc in Musician's DystoniaCompletedNCT00208091Phase 4
2Ultrasound Guided Intermediate Cervical Plexus Block for Congenital Muscular TorticollisRecruitingNCT02651311Phase 4
3Comparison of Electrophysiologic and Ultrasound Guidance for Onabotulinum Toxin A Injections in Focal Upper Extremity Dystonia and SpasticityRecruitingNCT02326818Phase 3
4Safety and Tolerability of Perampanel in Cervical DystoniaUnknown statusNCT02131467Phase 1, Phase 2
5Amlodipine Plus Botulinum Toxin for Focal DystoniaCompletedNCT00015457Phase 2
6Mexiletine for the Treatment of Focal DystoniaCompletedNCT00001784Phase 2
7Motor Training to Treat Hand DystoniaCompletedNCT00021853Phase 2
8A Study of Acetyl Hexapeptide-8 (AH8) in Treatment of BlepharospasmCompletedNCT00942851Phase 1, Phase 2
9rTMS and Retraining in Focal Hand DystoniaCompletedNCT01738581Phase 1, Phase 2
10Brain Stimulation to Treat Blepharospasm or Meige SyndromeCompletedNCT00411255Phase 2
11Transcranial Electrical Polarization to Treat Focal Hand DystoniaCompletedNCT00106782Phase 2
12Pilot Trial of Botulinum Toxin and Occupational Therapy for Writer's CrampCompletedNCT02015039Phase 1, Phase 2
13Incobotulinum Toxin A (Xeomin®) As A Treatment For Focal Task-Specific Dystonia Of The Musician's HandRecruitingNCT02107261Phase 2
14Deep Brain Stimulation Surgery for Focal Hand DystoniaNot yet recruitingNCT02911103Phase 1, Phase 2
15Acetyl Hexapeptide-8 for BlepharospasmTerminatedNCT01750346Phase 2
16Motor and Premotor Cortex Stimulation for Treatment of Secondary Focal Dystonia With Striato Palliadal Lesion : Evaluation of Safety and EffectivenessCompletedNCT00505323Phase 1
17Repetitive Transcranial Magnetic Stimulation for the Treatment of Focal Hand DystoniaCompletedNCT01884064Phase 1
18Magnetic Resonance (MR) Guided Functional Ultrasound-Neurosurgery for Movement DisordersCompletedNCT01698450Phase 1
19Role of Dopamine Receptors in Primary Focal DystoniasUnknown statusNCT01373840
20Somatosensory Processing in Focal Hand DystoniaUnknown statusNCT00579033
21Influence of Gaze Shift and Emotions on Symptoms of BlepharospasmUnknown statusNCT01759745
22Survey of Sensory and Motor Tricks in Focal DystoniaCompletedNCT00054652
23Association Between Focal Dystonia and Complex Regional Pain SyndromeCompletedNCT00595439
24Sensory Training to Treat Focal DystoniaCompletedNCT00006336
25Role of Neurotransmission and Functional CNS Networks in Spasmodic DysphoniaCompletedNCT00713414
26EEG and EMG Studies of Hand DystoniaCompletedNCT00025701
27Transcranial Magnetic Stimulation and Electrical Stimulation of Nerves to Study Focal DystoniaCompletedNCT00050024
28Brain Changes in Patients With Focal Hand DystoniaCompletedNCT00306865
29Neurophysiology of Task-Specificity of Focal Hand DystoniaCompletedNCT00309010
30Brain Function in Focal DystoniaCompletedNCT00102999
31Movement-Related Brain Networks Involved in Hand DystoniaCompletedNCT00137384
32fMRI Studies of Task Specificity in Focal Hand DystoniaCompletedNCT00310414
33Transcranial Magnetic Stimulation (TMS) Studies of DystoniaCompletedNCT00017875
34Surround Inhibition in Patients With DystoniaCompletedNCT00029601
35Long-Term Motor Learning in Focal Hand DystoniaCompletedNCT00325091
36Movement Disorder Survey in East ChinaCompletedNCT01168388
37Neurophysiological Markers in Patients With Craniofacial Dystonia and Their RelativesCompletedNCT00082615
38Plasticity in Cervical DystoniaCompletedNCT00323765
39Cortical Excitability in Obsessive-Compulsive and Related DisordersCompletedNCT00029068
40Muscle Contraction in Patients With Focal Hand DystoniaCompletedNCT00376753
41Identification of Optimal Stimulation Site for Cervical Dystonia Symptoms: An Exploratory StudyCompletedNCT01859247
42Validating a New Writer s Cramp ScaleCompletedNCT01579266
43Extracorporeal Shock Wave Therapy (ESWT) for the Treatment of Spasticity in Persons With Spinal Cord InjuryCompletedNCT02203994
44MDs on Botox Utility (MOBILITY)CompletedNCT00535938
45Functional Connectivity in Primary Focal DystoniaRecruitingNCT01761903
46Compare Two Guidance Techniques for Botulinum Toxin Injections for the Treatment of Limb Spasticity and Focal DystoniaRecruitingNCT02334683
47Depotentiation in People With Focal Hand DystoniaRecruitingNCT02106936
48rTMS in Spasmodic DysphoniaRecruitingNCT02957942
49rTMS and Botulinum Toxin in Benign Essential BlepharospasmRecruitingNCT02370875
50rTMS and Botulinum Toxin in Primary Cervical DystoniaRecruitingNCT02542839

Search NIH Clinical Center for Focal Dystonia

Genetic Tests for Focal Dystonia

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Genetic tests related to Focal Dystonia:

id Genetic test Affiliating Genes
1 Focal Dystonia27

Anatomical Context for Focal Dystonia

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MalaCards organs/tissues related to Focal Dystonia:

36
Brain, Cortex, Spinal cord, Skin

Publications for Focal Dystonia

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Articles related to Focal Dystonia:

(show top 50)    (show all 211)
idTitleAuthorsYear
1
Poster 247 Treatment of Post-Traumatic Chronic Abdominal Pain due to Focal Dystonia with Onabotulinumtoxin A: Two Case Reports. (27673004)
2016
2
Lack of association between TOR1A and THAP1 mutations and sporadic adult-onset primary focal dystonia in a Chinese population. (26803725)
2016
3
Focal Dystonia in Hemiplegic Upper Limb: Favorable Effect of Cervical Microsurgical DREZotomy Involving the Ventral Horn - A Report of 3 Patients. (27225998)
2016
4
Adult onset primary focal dystonia of the foot: an orthopaedic intervention. (27030449)
2016
5
Is failed predictive control a risk factor for focal dystonia? (27787939)
2016
6
Sonographic Alteration of Basal Ganglia in Different Forms of Primary Focal Dystonia: A Cross-sectional Study. (27064039)
2016
7
The impact of stress on motor performance in skilled musicians suffering from focal dystonia: Physiological and psychological characteristics. (27033741)
2016
8
Epidemiological, clinical and genetic aspects of adult onset isolated focal dystonia in Ireland. (27647704)
2016
9
Neurofibromatosis type 1: focal dystonia associated with a malignant peripheral nerve sheath tumour-a video-illustrated case. (27797864)
2016
10
Effects of cerebellar theta-burst stimulation on arm and neck movement kinematics in patients with focal dystonia. (27721106)
2016
11
The curse of motor expertise: Use-dependent focal dystonia as a manifestation of maladaptive changes in body representation. (26689332)
2016
12
Mouse model of rare TOR1A variant found in sporadic focal dystonia impairs domains affected in DYT1 dystonia patients and animal models. (27168150)
2016
13
Rapidly Cycling Auras and Episodic Focal Dystonia in Anti-LGI1 Autoimmune Encephalitis. (27399958)
2016
14
Ataxia and focal dystonia in Kallmann syndrome. (26862419)
2016
15
High prevalence of primary focal dystonia in the Faroe Islands. (26041438)
2015
16
Sensory-motor integration in focal dystonia. (26164472)
2015
17
A Patient With Focal Dystonia That Occurred Secondary to a Peripheral Neurogenic Tumor: A Case Report. (26361606)
2015
18
The spread of primary late-onset focal dystonia in a long-term follow up study. (25764999)
2015
19
Life satisfaction of musicians with focal dystonia. (25964508)
2015
20
Isolated Focal Dystonia as a Disorder of Large-Scale Functional Networks. (26679193)
2015
21
Non-motor symptoms in patients with adult-onset focal dystonia: Sensory and psychiatric disturbances. (26360238)
2015
22
Hyoid muscle dystonia: A distinct focal dystonia syndrome. (26324211)
2015
23
Proprioceptive dysfunction in focal dystonia: from experimental evidence to rehabilitation strategies. (25538612)
2014
24
Connectivity patterns of pallidal DBS electrodes in focal dystonia: a diffusion tensor tractography study. (24045076)
2014
25
Focal dystonia and the Sensory-Motor Integrative Loop for Enacting (SMILE). (24999327)
2014
26
Focal dystonia in musicians: Phenomenology and musical triggering factors. (25102827)
2014
27
Psychiatric disorders in idiopathic-isolated focal dystonia. (24449065)
2014
28
Writer's cramp: is focal dystonia the best explanation? (23885297)
2013
29
Striatal dopamine D1-like receptor binding is unchanged in primary focal dystonia. (24151192)
2013
30
Focal dystonia in musicians: linking motor symptoms to somatosensory dysfunction. (23805090)
2013
31
Acute focal dystonia induced by a tricyclic antidepressant in a patient with Wilson disease: a case report. (24166573)
2013
32
Finger-specific loss of independent control of movements in musicians with focal dystonia. (23707706)
2013
33
Diagnosis and treatment of abductor hallucis focal dystonia with botulinum toxin injection: a case presentation. (23953019)
2013
34
Sensory tricks in focal dystonia and hemifacial spasm. (23216586)
2013
35
Focal dystonia of right hand with mirror movements upon use of left arm. (23673180)
2013
36
A model of task-specific focal dystonia. (23892909)
2013
37
Novel use of intrathecal baclofen drug delivery system for periodic focal dystonia in a teenager. (23009035)
2013
38
Kinematic analysis of grasping in focal dystonia of the face and neck. (23395859)
2013
39
kinesiotaping reduces pain and modulates sensory function in patients with focal dystonia: a randomized crossover pilot study. (23764884)
2013
40
Neurological picture. Isolated cerebellar hemiatrophy related with focal dystonia. (22842205)
2012
41
Neural network of primary focal dystonia by an anatomic likelihood estimation meta-analysis of gray matter abnormalities. (22349356)
2012
42
Obsessive-compulsive-spectrum symptoms in patients with focal dystonia, hemifacial spasm, and healthy subjects. (22450617)
2012
43
Epidural premotor cortical stimulation in primary focal dystonia: clinical and 18F-fluoro deoxyglucose positron emission tomography open study. (22344674)
2012
44
Limited regional cerebellar dysfunction induces focal dystonia in mice. (22850483)
2012
45
Musicians' social representations of health and illness: a qualitative case study about focal dystonia. (22246303)
2012
46
Steroid-responsive focal epilepsy with focal dystonia accompanied by glutamate receptor delta2 antibody. (22613698)
2012
47
Posttraumatic focal dystonia of the shoulder. (22691679)
2012
48
Botulinum toxin as treatment for focal dystonia: a systematic review of the pharmaco-therapeutic and pharmaco-economic value. (22552527)
2012
49
Treatment of focal dystonia. (22415705)
2012
50
Rehabilitation of a cellist whose vibrato was affected by focal dystonia. (23247881)
2012

Variations for Focal Dystonia

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Expression for genes affiliated with Focal Dystonia

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Search GEO for disease gene expression data for Focal Dystonia.

Pathways for genes affiliated with Focal Dystonia

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Pathways related to Focal Dystonia according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.2DRD2, DRD5, GNAL

GO Terms for genes affiliated with Focal Dystonia

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Cellular components related to Focal Dystonia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1ciliary membraneGO:00601709.6DRD2, DRD5

Biological processes related to Focal Dystonia according to GeneCards Suite gene sharing:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1chaperone-mediated protein transportGO:007232110.5TIMM8A, TOR1A
2activation of adenylate cyclase activityGO:000719010.4DRD5, GNAL
3adenylate cyclase-activating dopamine receptor signaling pathwayGO:000719110.4DRD5, GNAL
4adenylate cyclase-activating G-protein coupled receptor signaling pathwayGO:000718910.4DRD5, GNAL
5associative learningGO:000830610.1DRD2, DRD5
6regulation of dopamine uptake involved in synaptic transmissionGO:005158410.1DRD2, TOR1A
7phospholipase C-activating dopamine receptor signaling pathwayGO:006015810.1DRD2, DRD5
8response to amphetamineGO:000197510.0DRD2, DRD5
9response to cocaineGO:00422209.9DRD2, DRD5
10negative regulation of blood pressureGO:00457769.6DRD2, DRD5, GCH1
11synaptic transmission, dopaminergicGO:00019639.6DRD2, DRD5

Molecular functions related to Focal Dystonia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1dopamine bindingGO:00352409.7DRD2, DRD5
2dopamine neurotransmitter receptor activityGO:00049529.6DRD2, DRD5

Sources for Focal Dystonia

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet