MCID: FCL014
MIFTS: 45

Focal Epilepsy malady

Neuronal diseases category

Summaries for Focal Epilepsy

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9Disease Ontology, 66Wikipedia, 34MalaCards
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Disease Ontology:9 An epilepsy syndrome that is characterised by seizures that are preceded by an isolated disturbance of a cerebral function and arise from an epileptic focus, a small portion of the brain that serves as the irritant driving the epileptic response.

MalaCards: Focal Epilepsy, also known as localisation-related epilepsy, is related to idiopathic generalized epilepsy and complex partial epilepsy. An important gene associated with Focal Epilepsy is DEPDC5 (DEP domain containing 5). The drugs clorazepate and clorazepate dipotassium have been mentioned in the context of this disorder. Affiliated tissues include brain, temporal lobe and occipital lobe, and related mouse phenotypes are taste/olfaction and behavior/neurological.

Wikipedia:66 Focal seizures (also called partial seizures and localized seizures) are seizures which affect initially... more...

Aliases & Classifications for Focal Epilepsy

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9Disease Ontology, 11DISEASES, 63UMLS, 59SNOMED-CT, 36MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

focal epilepsy 9 11
localisation-related epilepsy 9
epilepsies, partial 63
partial epilepsy 9


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Disease Ontology9 DOID:2234
MeSH36 D004828

Related Diseases for Focal Epilepsy

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Focal Epilepsy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 84)
idRelated DiseaseScoreTop Affiliating Genes
1idiopathic generalized epilepsy29.9GABRD, SCN1B
2complex partial epilepsy10.8
3autosomal dominant partial epilepsy with auditory features10.6
4cerebritis10.5
5neuronitis10.4
6cortical dysplasia-focal epilepsy syndrome10.4
7benign infantile focal epilepsy with midline spikes and wave during sleep10.4
8status epilepticus10.3
9simple partial epilepsy10.3
10tetanus10.3
11focal epilepsy - intellectual disability - cerebro-cerebellar malformation10.2
12spinal meningioma10.1
13tuberous sclerosis10.1
14anxiety disorder10.1
15dystonia10.1
16encephalitis10.1
17hepatitis10.1
18intellectual disability10.1
19meningioma10.1
20porphyria10.1
21aneurysm10.1
22febrile seizures10.1
23memory impairment10.1
24ring chromosome 1410.1
25epileptic encephalopathy, early infantile, 1210.1
26malignant migrating partial seizures of infancy10.1
27neuronal migration disorders10.1
28epilepsy, familial temporal lobe, 110.1
29benign partial epilepsy with secondarily generalized seizures in infancy10.1
30benign partial epilepsy of infancy with complex partial seizures10.1
31dravet syndrome10.0GABRD, SCN1B
32subacute sclerosing panencephalitis10.0
33dysembryoplastic neuroepithelial tumor10.0
34intracranial aneurysm10.0
35hypoparathyroidism10.0
36west syndrome10.0
37cadasil10.0
38juvenile myoclonic epilepsy10.0
39aphasia10.0
40epilepsy syndrome10.0
41focal dystonia10.0
42hemiplegia10.0
43hyperglycemia10.0
44ischemia10.0
45meningitis10.0
46psychotic disorder10.0
47spinocerebellar ataxia10.0
48tuberous sclerosis complex10.0
49angiomatosis10.0
50ataxia10.0

Graphical network of the top 20 diseases related to Focal Epilepsy:



Diseases related to focal epilepsy

Symptoms for Focal Epilepsy

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Drugs & Therapeutics for Focal Epilepsy

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Focal Epilepsy

Search CenterWatch for Focal Epilepsy

Inferred drug relations via UMLS63/NDF-RT42:

Genetic Tests for Focal Epilepsy

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Anatomical Context for Focal Epilepsy

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34MalaCards
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MalaCards organs/tissues related to Focal Epilepsy:

34
Brain, Temporal lobe, Occipital lobe, Cortex, Testes, Amygdala, Eye, Thalamus, Caudate nucleus

Animal Models for Focal Epilepsy or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Focal Epilepsy:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053949.1CNTNAP2, EMX2
2MP:00053868.4GABRD, CNTNAP2, EMX2, SCN1B

Publications for Focal Epilepsy

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53PubMed
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Articles related to Focal Epilepsy:

(show top 50)    (show all 489)
idTitleAuthorsYear
1
Novel SCN3A variants associated with focal epilepsy in children. (24157691)
2014
2
Alteration of consciousness in focal epilepsy: the global workspace alteration theory. (24103816)
2014
3
EEG-fMRI correlation patterns in the presurgical evaluation of focal epilepsy: a comparison with electrocorticographic data and surgical outcome measures. (23454472)
2013
4
Asymmetry of planum temporale constrains interhemispheric language plasticity in children with focal epilepsy. (24022474)
2013
5
Meta-analyses of antiepileptic drugs for refractory partial (focal) epilepsy: an observation. (23738532)
2013
6
Combining ESI, ASL and PET for quantitative assessment of drug-resistant focal epilepsy. (23792219)
2013
7
Family history and frontal lobe seizures predict long-term remission in newly diagnosed cryptogenic focal epilepsy. (23968820)
2013
8
Comparison of bipolar versus monopolar extraoperative electrical cortical stimulation mapping in patients with focal epilepsy. (24135067)
2013
9
Mutations of DEPDC5 cause autosomal dominant focal epilepsies. (23542701)
2013
10
Long-term vagus nerve stimulation in children with focal epilepsy. (22994298)
2013
11
Optical control of focal epilepsy in vivo with caged I^-aminobutyric acid. (22275253)
2012
12
Sulthiame add-on therapy in children with focal epilepsies associated with encephalopathy related to electrical status epilepticus during slow sleep (ESES). (22509732)
2012
13
Levetiracetam add-on for drug-resistant focal epilepsy: an updated Cochrane Review. (22972056)
2012
14
Genetic analysis of tuberous-sclerosis genes 1 and 2 in nonlesional focal epilepsy. (21555252)
2011
15
A focal epilepsy and intellectual disability syndrome is due to a mutation in TBC1D24. (20797691)
2010
16
BOLD signal changes preceding negative responses in EEG-fMRI in patients with focal epilepsy. (20550554)
2010
17
Continuous motor monitoring enhances functional preservation and seizure-free outcome in surgery for intractable focal epilepsy. (20437060)
2010
18
Differential contributions of objective memory and mood to subjective memory complaints in refractory focal epilepsy. (20947435)
2010
19
Recruitment of motor cortex inhibition differentiates between generalized and focal epilepsy. (19286351)
2009
20
Early-onset symptomatic focal epilepsy: a dilemma in the timing of surgery. (19017580)
2008
21
Late EEG responses triggered by transcranial magnetic stimulation (TMS) in the evaluation of focal epilepsy. (18028404)
2008
22
Outcome of adult patients with temporal lobe tumours and medically refractory focal epilepsy. (17940725)
2007
23
A rapid and reliable procedure to localize subdural electrodes in presurgical evaluation of patients with drug-resistant focal epilepsy. (16403486)
2006
24
Quantitative HMRS and MRI volumetry indicate neuronal damage in the hippocampus of children with focal epilepsy and infrequent seizures. (15857435)
2005
25
Benign focal epilepsy with onset in infancy in a patient with 18q-syndrome. (14691641)
2004
26
Benign focal epilepsy of childhood: epileptic seizure during somatosensory evoked potential: a case report. (15164817)
2004
27
Midline Spikes Associated with Focal Epilepsy. (15309138)
2002
28
Course of chronic focal epilepsy resistant to anticonvulsant treatment. (11466018)
2001
29
SPECT in focal epilepsies. (11455043)
2000
30
Selection criteria and preoperative investigation of patients with focal epilepsy who lack a localized structural lesion. (11174153)
2000
31
Gabapentin as add-on therapy in focal epilepsy: a computerized EEG study. (10680567)
2000
32
Effects of lamotrigine on nocturnal sleep, daytime somnolence and cognitive functions in focal epilepsy. (10949523)
2000
33
A chronic focal epilepsy with mossy fiber sprouting follows recurrent seizures induced by intrahippocampal tetanus toxin injection in infant rats. (10392831)
1999
34
Focal seizures versus focal epilepsy in infancy: a challenging distinction. (10937144)
1999
35
Animal models of focal epilepsy. (10674138)
1999
36
Pharmacotherapy of focal epilepsy after surgical treatment. (9757452)
1998
37
P3 latency jitter assessed using 2 techniques. II. Surface and sphenoidal recordings in subjects with focal epilepsy. (7527774)
1994
38
A neural network model for kindling of focal epilepsy: basic mechanism. (8476976)
1993
39
History of focal epilepsy and criteria for medical intractability. (8467205)
1993
40
Asymmetry in delta activity in patients with focal epilepsy. (1693892)
1990
41
Microdysgenesis in resected temporal neocortex: incidence and clinical significance in focal epilepsy. (3386820)
1988
42
Regional cerebral blood flow of patients with focal epilepsy studied using xenon enhanced CT brain scanning. (3125306)
1987
43
Therapeutic plasma levels of some anticonvulsants in focal epilepsy in relation to computerized axial tomography. (6785071)
1981
44
Cerebral angiography in focal epilepsy. (4633833)
1972
45
"Cryptic tubers" as a cause of focal epilepsy. (4994607)
1971
46
Effect of allobarbital on focal epilepsy in rats. (4335127)
1971
47
Benign focal epilepsy in children. (4192845)
1970
48
Clinical studies of patients with focal epilepsy due to "chronic encephalitis". (4974863)
1968
49
SUCCESSFUL EXTIRPATION OF LARGE NON-RUPTURED SACCULAR ANEURYSM OF THE MIDDLE CEREBRAL ARTERY, MANIFESTING ITSELF BY FOCAL EPILEPSY: (WITH A SHORT SURVEY OF PERSONAL EXPERIENCES WITH SACCULAR ANEURYSMS OF THE MIDDLE CEREBRAL ARTERY). (14062206)
1963
50
Focal epilepsy; surgical findings in 43 selected patients and reports on six cases of special interest. (13385566)
1957

Variations for Focal Epilepsy

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Expression for genes affiliated with Focal Epilepsy

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Focal Epilepsy

Search GEO for disease gene expression data for Focal Epilepsy.

Pathways for genes affiliated with Focal Epilepsy

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Compounds for genes affiliated with Focal Epilepsy

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GO Terms for genes affiliated with Focal Epilepsy

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17Gene Ontology
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Biological processes related to Focal Epilepsy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuron projection developmentGO:0311759.6TBC1D24, CNTNAP2

Products for genes affiliated with Focal Epilepsy

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Sources for Focal Epilepsy

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet