Aliases & Classifications for Focal Epilepsy

About this section

Focal Epilepsy, Aliases & Descriptions:

Name: Focal Epilepsy 9 11
Localisation-Related Epilepsy 9
 
Epilepsies, Partial 60
Partial Epilepsy 9


External Ids:

Disease Ontology9 DOID:2234
MeSH33 D004828

Summaries for Focal Epilepsy

About this section


Disease Ontology:9 An epilepsy syndrome that is characterised by seizures that are preceded by an isolated disturbance of a cerebral function and arise from an epileptic focus, a small portion of the brain that serves as the irritant driving the epileptic response.

MalaCards based summary: Focal Epilepsy, also known as localisation-related epilepsy, is related to complex partial epilepsy and autosomal dominant partial epilepsy with auditory features. An important gene associated with Focal Epilepsy is DEPDC5 (DEP domain containing 5). The drugs topiramate and gabapentin have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and temporal lobe, and related mouse phenotypes are taste/olfaction and behavior/neurological.

Related Diseases for Focal Epilepsy

About this section

Diseases related to Focal Epilepsy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 81)
idRelated DiseaseScoreTop Affiliating Genes
1complex partial epilepsy10.8
2autosomal dominant partial epilepsy with auditory features10.7
3cerebritis10.5
4cortical dysplasia-focal epilepsy syndrome10.4
5benign infantile focal epilepsy with midline spikes and wave during sleep10.4
6neuronitis10.4
7simple partial epilepsy10.3
8status epilepticus10.3
9tetanus10.3
10focal epilepsy - intellectual disability - cerebro-cerebellar malformation10.3
11malignant migrating partial seizures of infancy10.2
12blindness10.2
13benign partial epilepsy with secondarily generalized seizures in infancy10.2
14benign partial epilepsy of infancy with complex partial seizures10.2
15stiff-person syndrome10.2
16hepatitis10.1
17spinal meningioma10.1
18tuberous sclerosis10.1
19anxiety disorder10.1
20dystonia10.1
21encephalitis10.1
22porphyria10.1
23aneurysm10.1
24febrile seizures10.1
25ring chromosome 1410.1
26neuronal migration disorders10.1
27epilepsy, idiopathic generalized10.0GABRD, SCN1B
28hypochondroplasia10.0
29epilepsy, nocturnal frontal lobe, 510.0
30epilepsy, focal, with speech disorder and with or without mental retardation10.0
31epilepsy, familial focal, with variable foci10.0
32celiac disease10.0
33epilepsy, nocturnal frontal lobe, type 410.0
34centrotemporal epilepsy10.0
35fragile x syndrome10.0
36west syndrome10.0
37subacute sclerosing panencephalitis10.0
38childhood absence epilepsy10.0
39dysembryoplastic neuroepithelial tumor10.0
40periodic limb movement disorder10.0
41benign epilepsy with centrotemporal spikes10.0
42hypoparathyroidism10.0
43cadasil10.0
44aphasia10.0
45epilepsy syndrome10.0
46focal dystonia10.0
47hemiplegia10.0
48hyperglycemia10.0
49intracranial aneurysm10.0
50ischemia10.0

Graphical network of the top 20 diseases related to Focal Epilepsy:



Diseases related to focal epilepsy

Symptoms for Focal Epilepsy

About this section

Drugs & Therapeutics for Focal Epilepsy

About this section

Genetic Tests for Focal Epilepsy

About this section

Anatomical Context for Focal Epilepsy

About this section

MalaCards organs/tissues related to Focal Epilepsy:

31
Brain, Cortex, Temporal lobe, Testes, Amygdala, Eye, Occipital lobe, Thalamus, Caudate nucleus

Animal Models for Focal Epilepsy or affiliated genes

About this section

MGI Mouse Phenotypes related to Focal Epilepsy:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053949.1CNTNAP2, EMX2
2MP:00053868.4GABRD, CNTNAP2, EMX2, SCN1B

Publications for Focal Epilepsy

About this section

Articles related to Focal Epilepsy:

(show top 50)    (show all 537)
idTitleAuthorsYear
1
Familial focal epilepsy with focal cortical dysplasia due to DEPDC5 mutations. (25623524)
2015
2
PET/MRI and PET/MRI/SISCOM coregistration in the presurgical evaluation of refractory focal epilepsy. (25769367)
2015
3
Dynamic preictal relations in FCD type II: potential for early seizure detection in focal epilepsy. (25616452)
2015
4
Focal epilepsy presenting as a bath-induced paroxysmal event/breath-holding attack. (25667882)
2014
5
"Subtotal" hemispherectomy in children with intractable focal epilepsy. (25366422)
2014
6
Novel SCN3A variants associated with focal epilepsy in children. (24157691)
2014
7
Bilateral intracranial EEG with corpus callosotomy may uncover seizure focus in nonlocalizing focal epilepsy. (25218113)
2014
8
EEG-fMRI correlation patterns in the presurgical evaluation of focal epilepsy: a comparison with electrocorticographic data and surgical outcome measures. (23454472)
2013
9
Asymmetry of planum temporale constrains interhemispheric language plasticity in children with focal epilepsy. (24022474)
2013
10
Meta-analyses of antiepileptic drugs for refractory partial (focal) epilepsy: an observation. (23738532)
2013
11
Combining ESI, ASL and PET for quantitative assessment of drug-resistant focal epilepsy. (23792219)
2013
12
Family history and frontal lobe seizures predict long-term remission in newly diagnosed cryptogenic focal epilepsy. (23968820)
2013
13
Comparison of bipolar versus monopolar extraoperative electrical cortical stimulation mapping in patients with focal epilepsy. (24135067)
2013
14
Mutations of DEPDC5 cause autosomal dominant focal epilepsies. (23542701)
2013
15
Optical control of focal epilepsy in vivo with caged I^-aminobutyric acid. (22275253)
2012
16
Sulthiame add-on therapy in children with focal epilepsies associated with encephalopathy related to electrical status epilepticus during slow sleep (ESES). (22509732)
2012
17
Levetiracetam add-on for drug-resistant focal epilepsy: an updated Cochrane Review. (22972056)
2012
18
Genetic analysis of tuberous-sclerosis genes 1 and 2 in nonlesional focal epilepsy. (21555252)
2011
19
A focal epilepsy and intellectual disability syndrome is due to a mutation in TBC1D24. (20797691)
2010
20
BOLD signal changes preceding negative responses in EEG-fMRI in patients with focal epilepsy. (20550554)
2010
21
Continuous motor monitoring enhances functional preservation and seizure-free outcome in surgery for intractable focal epilepsy. (20437060)
2010
22
Differential contributions of objective memory and mood to subjective memory complaints in refractory focal epilepsy. (20947435)
2010
23
Recruitment of motor cortex inhibition differentiates between generalized and focal epilepsy. (19286351)
2009
24
Early-onset symptomatic focal epilepsy: a dilemma in the timing of surgery. (19017580)
2008
25
Outcome of adult patients with temporal lobe tumours and medically refractory focal epilepsy. (17940725)
2007
26
A rapid and reliable procedure to localize subdural electrodes in presurgical evaluation of patients with drug-resistant focal epilepsy. (16403486)
2006
27
Quantitative HMRS and MRI volumetry indicate neuronal damage in the hippocampus of children with focal epilepsy and infrequent seizures. (15857435)
2005
28
Benign focal epilepsy with onset in infancy in a patient with 18q-syndrome. (14691641)
2004
29
Benign focal epilepsy of childhood: epileptic seizure during somatosensory evoked potential: a case report. (15164817)
2004
30
Midline Spikes Associated with Focal Epilepsy. (15309138)
2002
31
Course of chronic focal epilepsy resistant to anticonvulsant treatment. (11466018)
2001
32
SPECT in focal epilepsies. (11455043)
2000
33
Selection criteria and preoperative investigation of patients with focal epilepsy who lack a localized structural lesion. (11174153)
2000
34
Gabapentin as add-on therapy in focal epilepsy: a computerized EEG study. (10680567)
2000
35
Effects of lamotrigine on nocturnal sleep, daytime somnolence and cognitive functions in focal epilepsy. (10949523)
2000
36
A chronic focal epilepsy with mossy fiber sprouting follows recurrent seizures induced by intrahippocampal tetanus toxin injection in infant rats. (10392831)
1999
37
Focal seizures versus focal epilepsy in infancy: a challenging distinction. (10937144)
1999
38
Pharmacotherapy of focal epilepsy after surgical treatment. (9757452)
1998
39
P3 latency jitter assessed using 2 techniques. II. Surface and sphenoidal recordings in subjects with focal epilepsy. (7527774)
1994
40
A neural network model for kindling of focal epilepsy: basic mechanism. (8476976)
1993
41
History of focal epilepsy and criteria for medical intractability. (8467205)
1993
42
Microdysgenesis in resected temporal neocortex: incidence and clinical significance in focal epilepsy. (3386820)
1988
43
Regional cerebral blood flow of patients with focal epilepsy studied using xenon enhanced CT brain scanning. (3125306)
1987
44
Therapeutic plasma levels of some anticonvulsants in focal epilepsy in relation to computerized axial tomography. (6785071)
1981
45
"Cryptic tubers" as a cause of focal epilepsy. (4994607)
1971
46
Effect of allobarbital on focal epilepsy in rats. (4335127)
1971
47
Benign focal epilepsy in children. (4192845)
1970
48
Clinical studies of patients with focal epilepsy due to "chronic encephalitis". (4974863)
1968
49
SUCCESSFUL EXTIRPATION OF LARGE NON-RUPTURED SACCULAR ANEURYSM OF THE MIDDLE CEREBRAL ARTERY, MANIFESTING ITSELF BY FOCAL EPILEPSY: (WITH A SHORT SURVEY OF PERSONAL EXPERIENCES WITH SACCULAR ANEURYSMS OF THE MIDDLE CEREBRAL ARTERY). (14062206)
1963
50
Focal epilepsy; surgical findings in 43 selected patients and reports on six cases of special interest. (13385566)
1957

Variations for Focal Epilepsy

About this section

Expression for genes affiliated with Focal Epilepsy

About this section
Search GEO for disease gene expression data for Focal Epilepsy.

Pathways for genes affiliated with Focal Epilepsy

About this section

Compounds for genes affiliated with Focal Epilepsy

About this section

GO Terms for genes affiliated with Focal Epilepsy

About this section

Biological processes related to Focal Epilepsy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1neuron projection developmentGO:00311759.6TBC1D24, CNTNAP2

Products for genes affiliated with Focal Epilepsy

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Focal Epilepsy

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet