MCID: FCL010
MIFTS: 38

Focal Epithelial Hyperplasia malady

Categories: Infectious diseases, Oral diseases

Aliases & Classifications for Focal Epithelial Hyperplasia

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Aliases & Descriptions for Focal Epithelial Hyperplasia:

Name: Focal Epithelial Hyperplasia 11 13 48 37 66
Multifocal Epithelial Hyperplasia 11
 
Heck's Disease 11
Heck Disease 11

Classifications:



External Ids:

Disease Ontology11 DOID:5362
MeSH37 D017573
SNOMED-CT60 36949004, 6121001
NCIt43 C97083

Summaries for Focal Epithelial Hyperplasia

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Disease Ontology:11 A viral infectious disease that results in infection located in mouth, has material basis in human papillomavirus (types 13 or 32), has symptom papules or nodules in the oral cavity.

MalaCards based summary: Focal Epithelial Hyperplasia, also known as multifocal epithelial hyperplasia, is related to panuveitis and duodenal benign neoplasm, and has symptoms including papules or nodules in the oral cavity, oral manifestations and penile warts. An important gene associated with Focal Epithelial Hyperplasia is HLA-DRB1 (Major Histocompatibility Complex, Class II, DR Beta 1), and among its related pathways are HTLV-I infection and ICos-ICosL Pathway in T-Helper Cell. Affiliated tissues include mouth, liver and tongue.

Wikipedia:69 Heck\'s disease (also known as focal or multifocal epithelial hyperplasia) is an asymptomatic, benign... more...

Related Diseases for Focal Epithelial Hyperplasia

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Diseases related to Focal Epithelial Hyperplasia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 67)
idRelated DiseaseScoreTop Affiliating Genes
1panuveitis10.3HLA-DQA1, HLA-DRB1
2duodenal benign neoplasm10.3HLA-DQA1, HLA-DRB1
3fruit allergy10.2HLA-DQB1, HLA-DRB1
4quinquaud's decalvans folliculitis10.2HLA-DQB1, HLA-DRB1
5bile duct signet ring cell carcinoma10.2HLA-DQA1, HLA-DRB1
6pediatric systemic lupus erythematosus10.2HLA-DQB1, HLA-DRB1
7vitreoretinochoroidopathy dominant10.2HLA-DQB1, HLA-DRB1
8renovascular hypertension10.2HLA-DQA1, HLA-DRB1
9krieble bixler syndrome10.2HLA-DQB1, HLA-DRB1
10limb dystonia10.2HLA-DQB1, HLA-DRB1
11spondylarthropathy10.2HLA-DQB1, HLA-DRB1
12borst-jadassohn intraepidermal carcinoma10.2HLA-DQA1, HLA-DRB1
13mitochondrial encephalomyopathy10.2HLA-DQB1, HLA-DRB1
14rheumatic myocarditis10.2HLA-DQB1, HLA-DRB1
15nebulin-related early-onset distal myopathy10.2HLA-DQB1, HLA-DRB1
16purpura fulminans10.2HLA-DQB1, HLA-DRB1
17lymphocytic colitis10.2HLA-DQB1, HLA-DRB1
18peripheral t-cell lymphoma10.2HLA-DQB1, HLA-DRB1
19foster-kennedy syndrome10.2HLA-DQB1, HLA-DRB1
20thrombocytopenia due to platelet alloimmunization10.2HLA-DQB1, HLA-DRB1
21orbit alveolar rhabdomyosarcoma10.2HLA-DQB1, HLA-DRB1
22hordeolum externum10.2HLA-DQA1, HLA-DRB1
23lipodermatosclerosis10.2HLA-DQB1, HLA-DRB1
24x-linked congenital generalized hypertrichosis10.2HLA-DQB1, HLA-DRB1
25osteogenesis imperfecta congenita, microcephaly, and cataracts10.2HLA-DQA1, HLA-DQB1
26idiopathic central precocious puberty10.2HLA-DQB1, HLA-DRB1
27sensorineural hearing loss10.2HLA-DQB1, HLA-DRB1
28mononeuritis of upper limb10.1HLA-DQB1, HLA-DRB1
29sternum lymphoma10.1HLA-DQA1, HLA-DRB1
30allergic hypersensitivity disease10.1HLA-DQB1, HLA-DRB1
31hypoxia10.1HLA-DQB1, HLA-DRB1
32histoplasmosis pericarditis10.1HLA-DQA1, HLA-DRB1
33cirrhotic cardiomyopathy10.1HLA-DQB1, HLA-DRB1
34selective igm deficiency disease10.1HLA-DQA1, HLA-DQB1
35epidermolysis bullosa simplex superficialis10.1HLA-DQB1, HLA-DRB1
36spinal atrophy ophthalmoplegia pyramidal syndrome10.1HLA-DQB1, HLA-DRB1
37ampulla of vater neoplasm10.1HLA-DQA1, HLA-DQB1
38adult malignant hemangiopericytoma10.1HLA-DQA1, HLA-DRB1
39juvenile dermatitis herpetiformis10.1HLA-DQA1, HLA-DQB1
40conjunctival pigmentation10.1HLA-DQB1, HLA-DRB1
41breast carcinoma in situ10.1HLA-DQB1, HLA-DRB1
42subcorneal pustular dermatosis10.0HLA-DQB1, HLA-DRB1
43papilloma10.0
44intermittent proptosis10.0HLA-DQA1, HLA-DRB1
45aspartylglucosaminuria9.9HLA-DQA1, HLA-DRB1
46leukocyte adhesion deficiency9.8
47keratoacanthoma9.8
48molluscum contagiosum9.8
49parsonage turner syndrome9.7HLA-DQA1, HLA-DQB1, HLA-DRB1
50myopathy-growth delay-intellectual disability-hypospadias syndrome9.7HLA-DQA1, HLA-DQB1, HLA-DRB1

Graphical network of the top 20 diseases related to Focal Epithelial Hyperplasia:



Diseases related to focal epithelial hyperplasia

Symptoms for Focal Epithelial Hyperplasia

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Symptoms:

 11
  • papules or nodules in the oral cavity

UMLS symptoms related to Focal Epithelial Hyperplasia:


oral manifestations, penile warts

Drugs & Therapeutics for Focal Epithelial Hyperplasia

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Drugs for Focal Epithelial Hyperplasia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
ChitosanNutraceutical419012-76-471853
Synonyms:
CTA 4
Chicol
Chitopearl 3510
Chitopearl BC 3000
Chitopearl BCW 2500
Chitopearl BCW 3000
Chitopearl BCW 3500
Chitopearl BCW 3505
Chitopearl BCW 3507
Deacetylchitin
Flonac C
Flonac N
 
Kimitsu Chitosan F
Kimitsu Chitosan F 2
Kimitsu Chitosan H
Kimitsu Chitosan L
Kimitsu Chitosan M
Kytex H
Kytex M
Poliglusam
Sea Cure F
Sea Cure Plus
YEA
beta-1,4-Poly-D-glucosamine
beta-1,4-Poly-delta-glucosamine

Interventional clinical trials:

idNameStatusNCT IDPhase
1Quantitative Real-time Ultrasound Elastography for Characterisation of Liver TumorsCompletedNCT02156700
2Nonneoplastic Epithelial Disorders of Vulva and High Intensity Focused UltrasoundRecruitingNCT02890277
3Risk Factors for Concurrent Endometrial Carcinoma in Patients With a Curettage Diagnosis of Endometrial HyperplasiaRecruitingNCT01273636

Search NIH Clinical Center for Focal Epithelial Hyperplasia


Cochrane evidence based reviews: focal epithelial hyperplasia

Genetic Tests for Focal Epithelial Hyperplasia

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Anatomical Context for Focal Epithelial Hyperplasia

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MalaCards organs/tissues related to Focal Epithelial Hyperplasia:

34
Liver, Tongue

FMA organs/tissues related to Focal Epithelial Hyperplasia:

17
Mouth

Animal Models for Focal Epithelial Hyperplasia or affiliated genes

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Publications for Focal Epithelial Hyperplasia

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Articles related to Focal Epithelial Hyperplasia:

(show top 50)    (show all 149)
idTitleAuthorsYear
1
Focal Epithelial Hyperplasia (Heck's Disease) in a 57-Year-Old Brazilian Patient: A Case Report and Literature Review. (26985258)
2016
2
Extensive Focal Epithelial Hyperplasia: A Case Report. (26351501)
2015
3
Molecular Biology for HPV Typing in Focal Epithelial Hyperplasia. (26456971)
2015
4
Focal epithelial hyperplasia (Heck's disease): a case report and review. (24706245)
2014
5
Focal epithelial hyperplasia - an update. (23061874)
2013
6
A Case Report of Focal Epithelial Hyperplasia (Heck's disease) with PCR Detection of Human Papillomavirus. (23204755)
2011
7
Focal epithelial hyperplasia: Case report. (22071419)
2011
8
Focal epithelial hyperplasia (Heck disease) related to highly active antiretroviral therapy in an HIV-seropositive child. A report of a case, and a review of the literature. (20632701)
2010
9
Focal epithelial hyperplasia: polymerase chain reaction amplification as a differential diagnosis tool. (19155739)
2009
10
Case of the month. Heck's disease (focal epithelial hyperplasia). (19405233)
2009
11
What is your diagnosis? Focal epithelial hyperplasia (Heck disease). (16706237)
2006
12
Molecular and serological evidence of the epidemiological association of HPV 13 with focal epithelial hyperplasia: a case-control study. (16793332)
2006
13
General practitioner's pathology case 9. Focal epithelial hyperplasia. (17201309)
2006
14
Extensive focal epithelial hyperplasia: case report. (16324231)
2005
15
Oral pathology quiz #48. Case number 2. Focal epithelial hyperplasia. (16795955)
2005
16
Clinical, histopathological and virological findings in patients with focal epithelial hyperplasia from Colombia. (15811076)
2005
17
Association of HLA-DR4 (DRB1*0404) with human papillomavirus infection in patients with focal epithelial hyperplasia. (15492185)
2004
18
Focal epithelial hyperplasia: report of six cases from Ghana, West Africa. (12413174)
2002
19
Focal epithelial hyperplasia (Heck's disease). (11526896)
2001
20
Diagnostic considerations in oral papillomatous lesions--case reports of focal epithelial hyperplasia. (9518811)
1996
21
Focal epithelial hyperplasia. (7534895)
1994
22
Heck's disease (focal epithelial hyperplasia): a longitudinal study. (8387416)
1993
23
Focal epithelial hyperplasia: Heck disease. (8415301)
1993
24
In situ hybridization with digoxigenin-labelled DNA probes for the detection of human papillomavirus-induced focal epithelial hyperplasia among Venezuelans. (1314447)
1992
25
Human papillomavirus (HPV) DNA in focal epithelial hyperplasia by in situ hybridization. (1648613)
1991
26
Focal epithelial hyperplasia (Heck's disease): the first reported case from Italy. (1850180)
1991
27
Focal epithelial hyperplasia (Heck's disease) in a Sudanese girl: case report. (2612415)
1989
28
Human papillomavirus type 13 DNA in focal epithelial hyperplasia among Mexicans. Brief report. (3028340)
1987
29
Disturbed expression of ribonucleotide reductase and cytokeratin polypeptides in focal epithelial hyperplasia. An immunohistochemical study using monoclonal antibodies. (2427675)
1986
30
Focal epithelial hyperplasia (Heck's disease). A case report. (3856655)
1985
31
Focal epithelial hyperplasia (Hecks' disease) in a Sudanese boy. Report of a case and review of literature. (6579515)
1983
32
Characterization of human papillomavirus type 13 from focal epithelial hyperplasia Heck lesions. (6312071)
1983
33
Focal epithelial hyperplasia in Sweden. (6948491)
1981
34
Focal epithelial hyperplasia. (6941143)
1981
35
Focal epithelial hyperplasia. The first reported case from Greece. (7262382)
1981
36
HPV 1 DNA in lesions of focal epithelial hyperplasia Heck. (6260042)
1980
37
Focal epithelial hyperplasia in rabbit oral mucosa. (115979)
1979
38
Focal epithelial hyperplasia in Israeli families of Libyan origin. (277883)
1978
39
Focal epithelial hyperplasia (Heck's disease). (271558)
1977
40
Focal epithelial hyperplasia in a group of South Africans: Its ultrastructural features. (402449)
1977
41
Focal epithelial hyperplasia in a group of south africans: Its clinical and microscopic features. (402448)
1977
42
Focal epithelial hyperplasia of the mouth: recently discovered in South Africa. (861174)
1977
43
Focal epithelial hyperplasia. Report of five new cases from Argentina. (1057126)
1975
44
Focal epithelial hyperplasia in a child from Surinam. (809377)
1975
45
Geographical aspects of oral focal epithelial hyperplasia. (4718559)
1973
46
Focal epithelial hyperplasia in an Israeli family. (4517103)
1973
47
Focal epithelial hyperplasia. Report of two cases from Israel and review of literature. (4682549)
1973
48
Focal epithelial hyperplasia (Heck's disease). (5280235)
1971
49
Focal epithelial hyperplasia of the oral mucosa in a south-west Greenlandic population. (5273696)
1970
50
Focal epithelial hyperplasia. Report of a case. (5245681)
1968

Variations for Focal Epithelial Hyperplasia

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Expression for genes affiliated with Focal Epithelial Hyperplasia

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Search GEO for disease gene expression data for Focal Epithelial Hyperplasia.

Pathways for genes affiliated with Focal Epithelial Hyperplasia

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Pathways related to Focal Epithelial Hyperplasia according to GeneCards Suite gene sharing:

(show all 22)
idSuper pathwaysScoreTop Affiliating Genes
18.9HLA-DQA1, HLA-DQB1, HLA-DRB1
2
Show member pathways
8.9HLA-DQA1, HLA-DQB1, HLA-DRB1
3
Show member pathways
8.9HLA-DQA1, HLA-DQB1, HLA-DRB1
48.9HLA-DQA1, HLA-DQB1, HLA-DRB1
5
Show member pathways
8.9HLA-DQA1, HLA-DQB1, HLA-DRB1
6
Show member pathways
8.9HLA-DQA1, HLA-DQB1, HLA-DRB1
7
Show member pathways
8.9HLA-DQA1, HLA-DQB1, HLA-DRB1
8
Show member pathways
8.9HLA-DQA1, HLA-DQB1, HLA-DRB1
9
Show member pathways
8.9HLA-DQA1, HLA-DQB1, HLA-DRB1
10
Show member pathways
8.9HLA-DQA1, HLA-DQB1, HLA-DRB1
11
Show member pathways
8.9HLA-DQA1, HLA-DQB1, HLA-DRB1
128.9HLA-DQA1, HLA-DQB1, HLA-DRB1
13
Show member pathways
8.9HLA-DQA1, HLA-DQB1, HLA-DRB1
148.9HLA-DQA1, HLA-DQB1, HLA-DRB1
158.9HLA-DQA1, HLA-DQB1, HLA-DRB1
168.9HLA-DQA1, HLA-DQB1, HLA-DRB1
17
Show member pathways
8.9HLA-DQA1, HLA-DQB1, HLA-DRB1
188.9HLA-DQA1, HLA-DQB1, HLA-DRB1
19
Show member pathways
8.9HLA-DQA1, HLA-DQB1, HLA-DRB1
208.9HLA-DQA1, HLA-DQB1, HLA-DRB1
218.9HLA-DQA1, HLA-DQB1, HLA-DRB1
228.9HLA-DQA1, HLA-DQB1, HLA-DRB1

GO Terms for genes affiliated with Focal Epithelial Hyperplasia

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Cellular components related to Focal Epithelial Hyperplasia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1MHC class II protein complexGO:00426139.4HLA-DQA1, HLA-DQB1, HLA-DRB1
2integral component of lumenal side of endoplasmic reticulum membraneGO:00715569.4HLA-DQA1, HLA-DQB1, HLA-DRB1
3clathrin-coated endocytic vesicle membraneGO:00306699.4HLA-DQA1, HLA-DQB1, HLA-DRB1
4ER to Golgi transport vesicle membraneGO:00125079.4HLA-DQA1, HLA-DQB1, HLA-DRB1
5trans-Golgi network membraneGO:00325889.3HLA-DQA1, HLA-DQB1, HLA-DRB1
6transport vesicle membraneGO:00306589.2HLA-DQA1, HLA-DQB1, HLA-DRB1
7endocytic vesicle membraneGO:00306669.1HLA-DQA1, HLA-DQB1, HLA-DRB1
8Golgi membraneGO:00001398.9HLA-DQA1, HLA-DQB1, HLA-DRB1
9lysosomal membraneGO:00057658.9HLA-DQA1, HLA-DQB1, HLA-DRB1

Biological processes related to Focal Epithelial Hyperplasia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1interferon-gamma-mediated signaling pathwayGO:00603339.2HLA-DQA1, HLA-DQB1, HLA-DRB1
2T cell receptor signaling pathwayGO:00508529.1HLA-DQA1, HLA-DQB1, HLA-DRB1
3T cell costimulationGO:00312958.9HLA-DQA1, HLA-DQB1, HLA-DRB1
4antigen processing and presentation of exogenous peptide antigen via MHC class IIGO:00198868.6HLA-DQA1, HLA-DQB1, HLA-DRB1

Molecular functions related to Focal Epithelial Hyperplasia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1MHC class II receptor activityGO:00323959.6HLA-DQA1, HLA-DQB1
2peptide antigen bindingGO:00426058.9HLA-DQA1, HLA-DQB1, HLA-DRB1

Sources for Focal Epithelial Hyperplasia

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet