MCID: FCL010
MIFTS: 38

Focal Epithelial Hyperplasia malady

Categories: Infectious diseases, Oral diseases

Aliases & Classifications for Focal Epithelial Hyperplasia

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Aliases & Descriptions for Focal Epithelial Hyperplasia:

Name: Focal Epithelial Hyperplasia 10 47 12 36 65
Multifocal Epithelial Hyperplasia 10
 
Heck's Disease 10
Heck Disease 10

Classifications:



External Ids:

Disease Ontology10 DOID:5362
MeSH36 D017573
SNOMED-CT59 36949004, 6121001
NCIt42 C97083
UMLS65 C0206067

Summaries for Focal Epithelial Hyperplasia

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Disease Ontology:10 A viral infectious disease that results in infection located in mouth, has material basis in human papillomavirus (types 13 or 32), has symptom papules or nodules in the oral cavity.

MalaCards based summary: Focal Epithelial Hyperplasia, also known as multifocal epithelial hyperplasia, is related to lymphoma and drug-induced mental disorder, and has symptoms including papules or nodules in the oral cavity An important gene associated with Focal Epithelial Hyperplasia is IFNA2 (Interferon, Alpha 2), and among its related pathways are and Epstein-Barr virus infection. Affiliated tissues include mouth, liver and prostate.

Wikipedia:68 Heck\'s disease (also known as focal or multifocal epithelial hyperplasia) is an asymptomatic, benign... more...

Related Diseases for Focal Epithelial Hyperplasia

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Diseases related to Focal Epithelial Hyperplasia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 168)
idRelated DiseaseScoreTop Affiliating Genes
1lymphoma10.2
2drug-induced mental disorder10.2HLA-DQA1, HLA-DRB1
3cryptosporidiosis10.1HLA-DQA1, HLA-DRB1
4lichen planus pemphigoides10.1HLA-DQB1, HLA-DRB1
5heavy chain deposition disease10.1HLA-DQB1, HLA-DRB1
6autoimmune polyglandular syndrome type 210.1HLA-DQB1, HLA-DRB1
7best1 retinopathy10.1HLA-DQB1, HLA-DRB1
8idiopathic juxtafoveal retinal telangiectasia10.1HLA-DQB1, HLA-DRB1
9non-distal monosomy 10q10.1HLA-DQB1, HLA-DRB1
10lichtenstein syndrome10.1HLA-DQB1, HLA-DRB1
11red cell phospholipid defect with hemolysis10.1HLA-DQB1, HLA-DRB1
12psoriasis10.1HLA-DQB1, HLA-DRB1
13colorectal cancer10.1
14hepatocellular carcinoma10.1
15breast cancer10.1
16hepatitis10.1
17melanoma10.1
18ischemia10.1
19laryngitis10.1
20retinitis10.1
21aneurysm10.1
22actinomycosis10.1HLA-DQB1, HLA-DRB1
23finnish upper limb-onset distal myopathy10.1HLA-DQB1, HLA-DRB1
24nut allergy10.1HLA-DQB1, HLA-DRB1
25lymphocytic choriomeningitis10.1HLA-DQB1, HLA-DRB1
26moderately severe hemophilia a10.1HLA-DQB1, HLA-DRB1
27angioid streaks10.1HLA-DQB1, HLA-DRB1
28cytoplasmic body myopathy10.1HLA-DQB1, HLA-DRB1
29hypertonia10.1HLA-DQB1, HLA-DRB1
30bipolar ll disorder10.1HLA-DQB1, HLA-DRB1
31focal hand dystonia10.1HLA-DQA1, HLA-DQB1
32hepatoid adenocarcinoma10.1HLA-DQB1, HLA-DRB1
33bubonic plague10.0HLA-DQB1, HLA-DRB1
34ichthyosis-hypotrichosis-sclerosing cholangitis syndrome10.0HLA-DQB1, HLA-DRB1
35duodenum cancer10.0HLA-DQA1, HLA-DQB1
36byssinosis10.0HLA-DQB1, HLA-DRB1
37human spumaretrovirus infection10.0HLA-DQB1, HLA-DRB1
38maculopapular lupus rash10.0HLA-DRB1, IFNA2
39bullous pemphigoid10.0HLA-DQA1, HLA-DQB1
40neuroblastoma10.0
41lung cancer10.0
42parathyroid carcinoma10.0
43hiv-110.0
44obesity10.0
45multiple system atrophy10.0
46osteoporosis10.0
47cystic fibrosis10.0
48anorexia nervosa10.0
49retinoblastoma10.0
50oculopharyngeal muscular dystrophy10.0

Graphical network of the top 20 diseases related to Focal Epithelial Hyperplasia:



Diseases related to focal epithelial hyperplasia

Symptoms for Focal Epithelial Hyperplasia

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Symptoms:

 10
  • papules or nodules in the oral cavity

Drugs & Therapeutics for Focal Epithelial Hyperplasia

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Drugs for Focal Epithelial Hyperplasia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1Liver Extracts3572

Interventional clinical trials:

idNameStatusNCT IDPhase
1Quantitative Real-time Ultrasound Elastography for Characterisation of Liver TumorsCompletedNCT02156700
2Risk Factors for Concurrent Endometrial Carcinoma in Patients With a Curettage Diagnosis of Endometrial HyperplasiaRecruitingNCT01273636

Search NIH Clinical Center for Focal Epithelial Hyperplasia


Cochrane evidence based reviews: focal epithelial hyperplasia

Genetic Tests for Focal Epithelial Hyperplasia

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Anatomical Context for Focal Epithelial Hyperplasia

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MalaCards organs/tissues related to Focal Epithelial Hyperplasia:

33
Liver, Prostate, Brain, Bone, Breast, Monocytes, Eye

FMA organs/tissues related to Focal Epithelial Hyperplasia:

16
Mouth

Animal Models for Focal Epithelial Hyperplasia or affiliated genes

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Publications for Focal Epithelial Hyperplasia

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Articles related to Focal Epithelial Hyperplasia:

(show top 50)    (show all 146)
idTitleAuthorsYear
1
Fever, confusion, acute kidney injury: is this atypical neuroleptic malignant syndrome following polypharmacy with clozapine and risperidone? (27194777)
2016
2
Clinical and immunological features of common variable immunodeficiency in China. (25635425)
2015
3
Long-term survival of ischemic cerebrovascular disease in the acute inflammatory stroke study, a hospital-based cohort described by TOAST and ASCO. (23466736)
2013
4
Vismodegib for the treatment of basal cell skin cancer. (23719880)
2013
5
RNA interference targeting human integrin I+6 suppresses the metastasis potential of hepatocellular carcinoma cells. (24304619)
2013
6
The efficacy of a family-based cognitive-behavioral treatment for separation anxiety disorder in children aged 8-13: a randomized comparison with a general anxiety program. (23607501)
2013
7
Force of infection is key to understanding the epidemiology of Plasmodium falciparum malaria in Papua New Guinean children. (22665809)
2012
8
Long-term chikungunya infection clinical manifestations after an outbreak in Italy: a prognostic cohort study. (22522292)
2012
9
Haplotype association of calpain 10 gene variants with type 2 diabetes mellitus in an Irish sample. (20119856)
2010
10
Foam sclerotherapy for reticular veins and nontruncal varicose veins of the legs: a retrospective review of outcomes and adverse effects. (20590709)
2010
11
Seipin S90L mutation in an Italian family with CMT2/dHMN and pyramidal signs. (20806400)
2010
12
Extrahepatic conditions associated with primary biliary cirrhosis. (19918979)
2010
13
Leptin as clinical target. (19594439)
2009
14
Preferential expression of truncated isoforms of FOXP1 in primary central nervous system lymphoma. (19680146)
2009
15
A conserved WD40 protein binds the Cajal body localization signal of scaRNP particles. (19285445)
2009
16
Nucleophosmin/B23 negatively regulates GCN5-dependent histone acetylation and transactivation. (18165222)
2008
17
An unusual cause of ascites: hemophagocytic lymphohistiocytosis. (17536139)
2007
18
Factor analysis of neuroanatomical and clinical characteristics of holoprosencephaly. (16503393)
2006
19
Cardiac malformations and midline skeletal defects in mice lacking filamin A. (16825286)
2006
20
Ramipril reduces large-artery stiffness in peripheral arterial disease and promotes elastogenic remodeling in cell culture. (15897362)
2005
21
Effect of rhIL-15 on TLR2 expression and apoptosis of PMN from patients with Lyme disease]. (16130298)
2005
22
Acarbose in obese patients with polycystic ovarian syndrome: a double-blind, randomized, placebo-controlled study. (16006454)
2005
23
Polymorphisms of the prion protein gene (PRNP) in a Korean population. (15148589)
2004
24
Autoimmune hemolytic anemia: magnetic resonance findings. (15528003)
2004
25
Laparoscopic unwinding and cyst aspiration of an ovarian torsion in spontaneous ovarian hyperstimulation syndrome associated with a singleton pregnancy. (15191459)
2004
26
Postherpetic neuralgia. (15366174)
2003
27
Sydenham's chorea in the age of MRI: a case report and review. (12160978)
2002
28
Differential binding to the alpha/beta-tubulin dimer of vinorelbine and vinflunine revealed by nuclear magnetic resonance analyses. (12167492)
2002
29
Carotid artery intima-media thickness and brachial artery flow-mediated vasodilation in asymptomatic Japanese male subjects amongst apolipoprotein E phenotypes. (12190886)
2002
30
A cathelicidin family of human antibacterial peptide LL-37 induces mast cell chemotaxis. (11972628)
2002
31
Cutaneous infection with Mycobacterium xenopi. (11204610)
2001
32
Autoimmune hemolytic anemia in chronic hepatitis C virus infection: an unusual extrahepatic autoimmune manifestation. (11799634)
2001
33
Downregulation of intercellular adhesion molecule-1 expression on human synovial fibroblasts by endothelin-1. (10090156)
1999
34
Cutting edge: recognition of Gram-positive bacterial cell wall components by the innate immune system occurs via Toll-like receptor 2. (10384090)
1999
35
Cloning and preliminary characterization of a 121 kDa protein with multiple predicted C2 domains. (10350628)
1999
36
Guidelines in electrodiagnostic medicine. Practice parameter for electrodiagnostic studies in ulnar neuropathy at the elbow. (16921634)
1999
37
LOD scores, location scores, and X-linked cone dystrophy. (9718326)
1998
38
A prognostic score for postherpetic neuralgia in ambulatory patients. (9861560)
1998
39
Experimental studies on the antitussive properties of the new xanthine derivative 1H-purine-2,6-dione, 3,7-dihydro-3-methyl-7[(5-methyl-1,2,4-oxadiazol-3-yl) methyl]. 3rd communication: examinations on opioid mechanisms and physical drug dependence. (9893929)
1998
40
Mouse Odf2 cDNAs consist of evolutionary conserved as well as highly variable sequences and encode outer dense fiber proteins of the sperm tail. (9740324)
1998
41
Anaplastic large cell lymphoma mimicking noduloulcerative tertiary syphilis. (9347238)
1997
42
Enhanced expression of the eosinophil-derived neurotoxin ribonuclease (RNS2) gene requires interaction between the promoter and intron. (8647842)
1996
43
Phosphorylation of the guanine nucleotide exchange factor and eukaryotic initiation factor 2 by casein kinase II regulates guanine nucleotide binding and GDP/GTP exchange. (8049218)
1994
44
Hyperinsulinemia decreases second-phase but not first-phase arginine-induced insulin release in humans. (7915241)
1994
45
Inhibition of proliferative activity of pulmonary fibroblasts by tetrandrine. (8104360)
1993
46
Case report and review of resolved fusariosis. (2203833)
1990
47
Construction of a human cytochrome c gene and its functional expression in Saccharomyces cerevisiae. (2844747)
1988
48
Studies on avian pleuropneumonia-like organisms. IV. Raising PPLO-free flock by antibiotic dip treatment. (6068468)
1967
49
Management of imperforate anus. (13514783)
1958
50
SUCCESSFUL CLOSURE OF SPINAL MENINGOCELE, FOLLOWED BY SEVERE REACTION. (20317579)
1929

Variations for Focal Epithelial Hyperplasia

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Expression for genes affiliated with Focal Epithelial Hyperplasia

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Search GEO for disease gene expression data for Focal Epithelial Hyperplasia.

Pathways for genes affiliated with Focal Epithelial Hyperplasia

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Pathways related to Focal Epithelial Hyperplasia according to GeneCards Suite gene sharing:

(show all 21)
idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
8.5
28.5HLA-DQA1, HLA-DQB1, HLA-DRB1
3
Show member pathways
8.5HLA-DQA1, HLA-DQB1, HLA-DRB1
4
Show member pathways
8.5HLA-DQA1, HLA-DQB1, HLA-DRB1
5
Show member pathways
8.5HLA-DQA1, HLA-DQB1, HLA-DRB1
68.5HLA-DQA1, HLA-DQB1, HLA-DRB1
7
Show member pathways
8.5HLA-DQA1, HLA-DQB1, HLA-DRB1
8
Show member pathways
8.5HLA-DQA1, HLA-DQB1, HLA-DRB1
9
Show member pathways
8.5HLA-DQA1, HLA-DQB1, HLA-DRB1
10
Show member pathways
8.5HLA-DQA1, HLA-DQB1, HLA-DRB1
118.5HLA-DQA1, HLA-DQB1, HLA-DRB1
128.5HLA-DQA1, HLA-DQB1, HLA-DRB1
138.5HLA-DQA1, HLA-DQB1, HLA-DRB1
148.5HLA-DQA1, HLA-DQB1, HLA-DRB1
15
Show member pathways
8.5HLA-DQA1, HLA-DQB1, HLA-DRB1
168.5HLA-DQA1, HLA-DQB1, HLA-DRB1
178.5HLA-DQA1, HLA-DQB1, HLA-DRB1
18
Show member pathways
8.1HLA-DQA1, HLA-DQB1, HLA-DRB1, IFNA2
19
Show member pathways
8.1HLA-DQA1, HLA-DQB1, HLA-DRB1, IFNA2
20
Show member pathways
8.1HLA-DQA1, HLA-DQB1, HLA-DRB1, IFNA2
218.1HLA-DQA1, HLA-DQB1, HLA-DRB1, IFNA2

GO Terms for genes affiliated with Focal Epithelial Hyperplasia

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Cellular components related to Focal Epithelial Hyperplasia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1MHC class II protein complexGO:00426139.5HLA-DQA1, HLA-DQB1
2integral component of lumenal side of endoplasmic reticulum membraneGO:00715569.4HLA-DQA1, HLA-DQB1
3endosome membraneGO:00100089.0HLA-DQA1, HLA-DQB1
4ER to Golgi transport vesicle membraneGO:00125078.5HLA-DQA1, HLA-DQB1, HLA-DRB1
5trans-Golgi network membraneGO:00325888.4HLA-DQA1, HLA-DQB1, HLA-DRB1

Biological processes related to Focal Epithelial Hyperplasia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1antigen processing and presentation of peptide or polysaccharide antigen via MHC class IIGO:00025049.8HLA-DQA1, HLA-DRB1
2immunoglobulin production involved in immunoglobulin mediated immune responseGO:00023819.6HLA-DQB1, HLA-DRB1
3cytokine-mediated signaling pathwayGO:00192218.9HLA-DQA1, HLA-DRB1, IFNA2
4antigen processing and presentationGO:00198828.7HLA-DQA1, HLA-DQB1, HLA-DRB1

Sources for Focal Epithelial Hyperplasia

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet