MCID: FCL010
MIFTS: 41

Focal Epithelial Hyperplasia malady

Categories: Infectious diseases, Oral diseases

Aliases & Classifications for Focal Epithelial Hyperplasia

About this section

Aliases & Descriptions for Focal Epithelial Hyperplasia:

Name: Focal Epithelial Hyperplasia 10 47 12 36 65
Multifocal Epithelial Hyperplasia 10
 
Heck's Disease 10
Heck Disease 10

Classifications:



External Ids:

Disease Ontology10 DOID:5362
MeSH36 D017573
SNOMED-CT59 36949004, 6121001
NCIt42 C97083
UMLS65 C0206067

Summaries for Focal Epithelial Hyperplasia

About this section
Disease Ontology:10 A viral infectious disease that results in infection located in mouth, has material basis in human papillomavirus (types 13 or 32), has symptom papules or nodules in the oral cavity.

MalaCards based summary: Focal Epithelial Hyperplasia, also known as multifocal epithelial hyperplasia, is related to drug-induced mental disorder and cryptosporidiosis, and has symptoms including papules or nodules in the oral cavity, penile warts and oral manifestations. An important gene associated with Focal Epithelial Hyperplasia is IFNA2 (Interferon, Alpha 2), and among its related pathways are TCR signaling (REACTOME) and Epstein-Barr virus infection. Affiliated tissues include mouth, liver and breast.

Wikipedia:68 Heck\'s disease (also known as focal or multifocal epithelial hyperplasia) is an asymptomatic, benign... more...

Related Diseases for Focal Epithelial Hyperplasia

About this section

Diseases related to Focal Epithelial Hyperplasia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 57)
idRelated DiseaseScoreTop Affiliating Genes
1drug-induced mental disorder10.3HLA-DQA1, HLA-DRB1
2cryptosporidiosis10.2HLA-DQA1, HLA-DRB1
3lichen planus pemphigoides10.2HLA-DQB1, HLA-DRB1
4heavy chain deposition disease10.2HLA-DQB1, HLA-DRB1
5autoimmune polyglandular syndrome type 210.2HLA-DQB1, HLA-DRB1
6best1 retinopathy10.2HLA-DQB1, HLA-DRB1
7idiopathic juxtafoveal retinal telangiectasia10.2HLA-DQB1, HLA-DRB1
8non-distal monosomy 10q10.2HLA-DQB1, HLA-DRB1
9lichtenstein syndrome10.2HLA-DQB1, HLA-DRB1
10red cell phospholipid defect with hemolysis10.2HLA-DQB1, HLA-DRB1
11psoriasis10.2HLA-DQB1, HLA-DRB1
12actinomycosis10.2HLA-DQB1, HLA-DRB1
13finnish upper limb-onset distal myopathy10.2HLA-DQB1, HLA-DRB1
14nut allergy10.2HLA-DQB1, HLA-DRB1
15lymphocytic choriomeningitis10.1HLA-DQB1, HLA-DRB1
16moderately severe hemophilia a10.1HLA-DQB1, HLA-DRB1
17angioid streaks10.1HLA-DQB1, HLA-DRB1
18cytoplasmic body myopathy10.1HLA-DQB1, HLA-DRB1
19hypertonia10.1HLA-DQB1, HLA-DRB1
20bipolar ll disorder10.1HLA-DQB1, HLA-DRB1
21focal hand dystonia10.1HLA-DQA1, HLA-DQB1
22hepatoid adenocarcinoma10.1HLA-DQB1, HLA-DRB1
23bubonic plague10.1HLA-DQB1, HLA-DRB1
24ichthyosis-hypotrichosis-sclerosing cholangitis syndrome10.1HLA-DQB1, HLA-DRB1
25duodenum cancer10.1HLA-DQA1, HLA-DQB1
26byssinosis10.1HLA-DQB1, HLA-DRB1
27human spumaretrovirus infection10.0HLA-DQB1, HLA-DRB1
28papilloma10.0
29maculopapular lupus rash10.0HLA-DRB1, IFNA2
30bullous pemphigoid10.0HLA-DQA1, HLA-DQB1
31autoimmune disease of musculoskeletal system9.9HLA-DQA1, HLA-DQB1
32juvenile dermatitis herpetiformis9.9HLA-DQB1, HLA-DRB1
33neurotic excoriation9.9HLA-DQA1, HLA-DQB1
34partial circumpapillary choroid dystrophy9.9HLA-DRB1, IFNA2
35enophthalmos9.9GP6, IFNA2
36leukocyte adhesion deficiency9.8
37keratoacanthoma9.8
38molluscum contagiosum9.8
39gerstmann-straussler disease9.7HLA-DQA1, HLA-DQB1
40sarcoidosis 19.7HLA-DQA1, HLA-DQB1
41tucker syndrome9.7HLA-DQA1, HLA-DQB1, HLA-DRB1
42metanephric adenoma9.7HLA-DQA1, HLA-DQB1, HLA-DRB1
43pulmonary nodular lymphoid hyperplasia9.7HLA-DQA1, HLA-DQB1, HLA-DRB1
44artery disease9.7HLA-DQA1, HLA-DQB1, HLA-DRB1
45rectal disease9.7HLA-DQA1, HLA-DQB1, HLA-DRB1
46lung lymphoma9.7HLA-DQA1, HLA-DQB1, HLA-DRB1
47liver fibroma9.7HLA-DQA1, HLA-DQB1, HLA-DRB1
48choledochal cyst9.7HLA-DQA1, HLA-DQB1, HLA-DRB1
49multiple sclerosis, disease progression, modifier of9.7HLA-DQA1, HLA-DQB1, HLA-DRB1
50thyrotoxic exophthalmos9.6HLA-DQA1, HLA-DQB1

Graphical network of the top 20 diseases related to Focal Epithelial Hyperplasia:



Diseases related to focal epithelial hyperplasia

Symptoms for Focal Epithelial Hyperplasia

About this section

Symptoms:

 10
  • papules or nodules in the oral cavity

UMLS symptoms related to Focal Epithelial Hyperplasia:


penile warts, oral manifestations

Drugs & Therapeutics for Focal Epithelial Hyperplasia

About this section

Drugs for Focal Epithelial Hyperplasia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1Liver Extracts3572

Interventional clinical trials:

idNameStatusNCT IDPhase
1Quantitative Real-time Ultrasound Elastography for Characterisation of Liver TumorsCompletedNCT02156700
2Risk Factors for Concurrent Endometrial Carcinoma in Patients With a Curettage Diagnosis of Endometrial HyperplasiaRecruitingNCT01273636

Search NIH Clinical Center for Focal Epithelial Hyperplasia


Cochrane evidence based reviews: focal epithelial hyperplasia

Genetic Tests for Focal Epithelial Hyperplasia

About this section

Anatomical Context for Focal Epithelial Hyperplasia

About this section

MalaCards organs/tissues related to Focal Epithelial Hyperplasia:

33
Liver, Breast, Lung, Prostate, Brain, Endothelial, Monocytes

FMA organs/tissues related to Focal Epithelial Hyperplasia:

16
Mouth

Animal Models for Focal Epithelial Hyperplasia or affiliated genes

About this section

Publications for Focal Epithelial Hyperplasia

About this section

Articles related to Focal Epithelial Hyperplasia:

(show top 50)    (show all 149)
idTitleAuthorsYear
1
Focal Epithelial Hyperplasia (Heck's Disease) in a 57-Year-Old Brazilian Patient: A Case Report and Literature Review. (26985258)
2016
2
Extensive Focal Epithelial Hyperplasia: A Case Report. (26351501)
2015
3
Molecular Biology for HPV Typing in Focal Epithelial Hyperplasia. (26456971)
2015
4
Focal epithelial hyperplasia (Heck's disease) in two Chinese females. (22154527)
2012
5
A Case Report of Focal Epithelial Hyperplasia (Heck's disease) with PCR Detection of Human Papillomavirus. (23204755)
2011
6
Focal epithelial hyperplasia: Case report. (22071419)
2011
7
Oral focal epithelial hyperplasia. (20863043)
2010
8
Focal epithelial hyperplasia (Heck disease) related to highly active antiretroviral therapy in an HIV-seropositive child. A report of a case, and a review of the literature. (20632701)
2010
9
Focal epithelial hyperplasia: polymerase chain reaction amplification as a differential diagnosis tool. (19155739)
2009
10
Case of the month. Heck's disease (focal epithelial hyperplasia). (19405233)
2009
11
What is your diagnosis? Focal epithelial hyperplasia (Heck disease). (16706237)
2006
12
Molecular and serological evidence of the epidemiological association of HPV 13 with focal epithelial hyperplasia: a case-control study. (16793332)
2006
13
Extensive focal epithelial hyperplasia: case report. (16324231)
2005
14
Oral pathology quiz #48. Case number 2. Focal epithelial hyperplasia. (16795955)
2005
15
Association of HLA-DR4 (DRB1*0404) with human papillomavirus infection in patients with focal epithelial hyperplasia. (15492185)
2004
16
Focal epithelial hyperplasia: report of six cases from Ghana, West Africa. (12413174)
2002
17
Focal epithelial hyperplasia (Heck's disease). (11526896)
2001
18
Focal epithelial hyperplasia: a multifocal oral human papillomavirus infection. (10769863)
2000
19
Focal epithelial hyperplasia in an Ecuadorian girl. (10626102)
1999
20
Focal epithelial hyperplasia in an HIV positive man. An illustrated case and review of the literature. (9848979)
1998
21
Focal epithelial hyperplasia. (7838556)
1995
22
Occurrence and resolution of focal epithelial hyperplasia in two siblings with leukocyte adhesion deficiency. (8433256)
1993
23
In situ hybridization with digoxigenin-labelled DNA probes for the detection of human papillomavirus-induced focal epithelial hyperplasia among Venezuelans. (1314447)
1992
24
Human papillomavirus (HPV) DNA in focal epithelial hyperplasia by in situ hybridization. (1648613)
1991
25
Focal epithelial hyperplasia (Heck's disease): the first reported case from Italy. (1850180)
1991
26
Focal epithelial hyperplasia: report of two cases and review of literature. (3466937)
1986
27
Focal epithelial hyperplasia: first report in MAcxico. Clinical, light and ultrastructural microscopic studies. (3592890)
1986
28
Immunohistochemical evidence of papillomavirus antigen in focal epithelial hyperplasia. (3006275)
1985
29
Focal epithelial hyperplasia (Heck's disease). A case report. (3856655)
1985
30
A human papillomavirus closely related to HPV 13 found in a focal epithelial hyperplasia lesion (Heck disease). (6089671)
1984
31
Focal epithelial hyperplasia. Report of nine cases from Sweden and review of the literature. (6587302)
1984
32
Focal epithelial hyperplasia (Hecks' disease) in a Sudanese boy. Report of a case and review of literature. (6579515)
1983
33
Characterization of human papillomavirus type 13 from focal epithelial hyperplasia Heck lesions. (6312071)
1983
34
Focal epithelial hyperplasia. Report of three cases from Nigeria, West Africa. (6578481)
1983
35
Focal epithelial hyperplasia in Sweden. (6948491)
1981
36
HPV 1 DNA in lesions of focal epithelial hyperplasia Heck. (6260042)
1980
37
Focal epithelial hyperplasia of the oral mucosa. A case report from the United Kingdom. (228693)
1979
38
Focal epithelial hyperplasia in Abu Dhabi. (277855)
1978
39
Focal epithelial hyperplasia in Israeli families of Libyan origin. (277883)
1978
40
Focal epithelial hyperplasia (Heck's disease). (271558)
1977
41
Focal epithelial hyperplasia. Report of five new cases from Argentina. (1057126)
1975
42
Focal epithelial hyperplasia in the oral mucosa of a chimpanzee. (4742089)
1973
43
Focal epithelial hyperplasia in an Eskimo population. (4500597)
1972
44
Focal epithelial hyperplasia: a virus-induced oral mucosal lesion in the chimpanzee. (4500596)
1972
45
Focal epithelial hyperplasia. A light and electron microscopic study of one case. (4503460)
1972
46
Focal epithelial hyperplasia. Report of a case in a South African Caucasoid. (5282068)
1971
47
Focal epithelial hyperplasia. Report of seven cases from Iraq. (5277369)
1971
48
Focal epithelial hyperplasia: report of a case in an Australian aborigine. (5286891)
1971
49
Focal epithelial hyperplasia in a half-breed family of Colombians. (5256372)
1969
50
Focal epithelial hyperplasia. Report of a case. (5245681)
1968

Variations for Focal Epithelial Hyperplasia

About this section

Expression for genes affiliated with Focal Epithelial Hyperplasia

About this section
Search GEO for disease gene expression data for Focal Epithelial Hyperplasia.

Pathways for genes affiliated with Focal Epithelial Hyperplasia

About this section

Pathways related to Focal Epithelial Hyperplasia according to GeneCards Suite gene sharing:

(show all 21)
idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
8.5HLA-DQA1, HLA-DQB1, HLA-DRB1
28.5HLA-DQA1, HLA-DQB1, HLA-DRB1
3
Show member pathways
8.5HLA-DQA1, HLA-DQB1, HLA-DRB1
4
Show member pathways
8.5HLA-DQA1, HLA-DQB1, HLA-DRB1
5
Show member pathways
8.5HLA-DQA1, HLA-DQB1, HLA-DRB1
68.5HLA-DQA1, HLA-DQB1, HLA-DRB1
7
Show member pathways
8.5HLA-DQA1, HLA-DQB1, HLA-DRB1
8
Show member pathways
8.5HLA-DQA1, HLA-DQB1, HLA-DRB1
9
Show member pathways
8.5HLA-DQA1, HLA-DQB1, HLA-DRB1
10
Show member pathways
8.5HLA-DQA1, HLA-DQB1, HLA-DRB1
118.5HLA-DQA1, HLA-DQB1, HLA-DRB1
128.5HLA-DQA1, HLA-DQB1, HLA-DRB1
138.5HLA-DQA1, HLA-DQB1, HLA-DRB1
148.5HLA-DQA1, HLA-DQB1, HLA-DRB1
15
Show member pathways
8.5HLA-DQA1, HLA-DQB1, HLA-DRB1
168.5HLA-DQA1, HLA-DQB1, HLA-DRB1
178.5HLA-DQA1, HLA-DQB1, HLA-DRB1
18
Show member pathways
8.1HLA-DQA1, HLA-DQB1, HLA-DRB1, IFNA2
19
Show member pathways
8.1HLA-DQA1, HLA-DQB1, HLA-DRB1, IFNA2
20
Show member pathways
8.1HLA-DQA1, HLA-DQB1, HLA-DRB1, IFNA2
218.1HLA-DQA1, HLA-DQB1, HLA-DRB1, IFNA2

GO Terms for genes affiliated with Focal Epithelial Hyperplasia

About this section

Cellular components related to Focal Epithelial Hyperplasia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1MHC class II protein complexGO:00426139.5HLA-DQA1, HLA-DQB1
2integral component of lumenal side of endoplasmic reticulum membraneGO:00715569.4HLA-DQA1, HLA-DQB1
3endosome membraneGO:00100089.0HLA-DQA1, HLA-DQB1
4ER to Golgi transport vesicle membraneGO:00125078.5HLA-DQA1, HLA-DQB1, HLA-DRB1
5trans-Golgi network membraneGO:00325888.4HLA-DQA1, HLA-DQB1, HLA-DRB1

Biological processes related to Focal Epithelial Hyperplasia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1antigen processing and presentation of peptide or polysaccharide antigen via MHC class IIGO:00025049.8HLA-DQA1, HLA-DRB1
2immunoglobulin production involved in immunoglobulin mediated immune responseGO:00023819.6HLA-DQB1, HLA-DRB1
3cytokine-mediated signaling pathwayGO:00192218.9HLA-DQA1, HLA-DRB1, IFNA2
4antigen processing and presentationGO:00198828.7HLA-DQA1, HLA-DQB1, HLA-DRB1

Sources for Focal Epithelial Hyperplasia

About this section
2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet