MCID: FCL010
MIFTS: 33

Focal Epithelial Hyperplasia malady

Infectious diseases, Oral diseases categories

Aliases & Classifications for Focal Epithelial Hyperplasia

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Sources:
10Disease Ontology, 47Novoseek, 12DISEASES, 65UMLS, 36MeSH, 59SNOMED-CT
See all sources

Aliases & Descriptions for Focal Epithelial Hyperplasia:

Name: Focal Epithelial Hyperplasia 10 47 12 65 36
Multifocal Epithelial Hyperplasia 10
 
Heck's Disease 10
Heck Disease 10


Classifications:



External Ids:

Disease Ontology10 DOID:5362
SNOMED-CT59 36949004, 6121001
MeSH36 D017573

Summaries for Focal Epithelial Hyperplasia

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Disease Ontology:10 A viral infectious disease that results in infection located in mouth, has material basis in human papillomavirus (types 13 or 32), has symptom papules or nodules in the oral cavity.

MalaCards based summary: Focal Epithelial Hyperplasia, also known as multifocal epithelial hyperplasia, is related to papilloma and leukocyte adhesion deficiency, and has symptoms including papules or nodules in the oral cavity An important gene associated with Focal Epithelial Hyperplasia is IFNA2 (Interferon, Alpha 2), and among its related pathways are and Epstein-Barr virus infection. Affiliated tissues include mouth and tongue.

Wikipedia:68 Heck\'s disease (also known as focal epithelial hyperplasia) is a condition characterized by white to... more...

Related Diseases for Focal Epithelial Hyperplasia

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Diseases related to Focal Epithelial Hyperplasia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 50)
idRelated DiseaseScoreTop Affiliating Genes
1papilloma10.4
2leukocyte adhesion deficiency10.2
3molluscum contagiosum10.2
4keratoacanthoma10.2
5best1 retinopathy10.1HLA-DQB1, HLA-DRB1
6lichen planus pemphigoides10.1HLA-DQB1, HLA-DRB1
7microsomia hemifacial radial defects10.1HLA-DQB1, HLA-DRB1
8heavy chain deposition disease10.1HLA-DQB1, HLA-DRB1
9autoimmune polyglandular syndrome type 210.1HLA-DQB1, HLA-DRB1
10childhood cerebellar astrocytic neoplasm10.1HLA-DQB1, HLA-DRB1
11finnish upper limb-onset distal myopathy10.1HLA-DQB1, HLA-DRB1
12senile atrophy of choroid10.1HLA-DQB1, HLA-DRB1
13microsporidiosis10.1HLA-DQB1, HLA-DRB1
14moderately severe hemophilia a10.1HLA-DQB1, HLA-DRB1
15cytoplasmic body myopathy10.1HLA-DQB1, HLA-DRB1
16ocular melanoma10.1HLA-DQB1, HLA-DRB1
17hypertonia10.1HLA-DQB1, HLA-DRB1
18histidinemia10.1HLA-DQB1, HLA-DRB1
19conn's syndrome10.1HLA-DQA1, HLA-DRB1
20baritosis10.1HLA-DQB1, HLA-DRB1
21hordeolum10.0HLA-DQA1, HLA-DRB1
22human spumaretrovirus infection10.0HLA-DQB1, HLA-DRB1
23intermediate anorectal malformation10.0HLA-DQA1, HLA-DQB1
24ichthyosis - hypotrichosis - sclerosing cholangitis10.0HLA-DQB1, HLA-DRB1
25endophthalmitis10.0HLA-DQA1, HLA-DQB1
26prostate stromal sarcoma10.0HLA-DQB1, HLA-DRB1
27maculopapular lupus rash10.0HLA-DRB1, IFNA2
28dermatomycosis10.0HLA-DQA1, HLA-DQB1
29hypertropia10.0HLA-DQB1, HLA-DRB1
30autoimmune disease of skin and connective tissue9.9HLA-DQA1, HLA-DQB1
31celiac disease9.9HLA-DQA1, HLA-DQB1
32tucker syndrome9.9HLA-DQA1, HLA-DQB1, HLA-DRB1
33acute endometritis9.9HLA-DQA1, HLA-DQB1, HLA-DRB1
34oculogyric crisis9.9HLA-DQA1, HLA-DQB1, HLA-DRB1
35pulmonary nodular lymphoid hyperplasia9.9HLA-DQA1, HLA-DQB1, HLA-DRB1
36small intestinal sarcoma9.9HLA-DQA1, HLA-DQB1, HLA-DRB1
37chronic inflammatory demyelinating polyradiculoneuropathy9.9HLA-DQA1, HLA-DQB1, HLA-DRB1
38lens disease9.9HLA-DQA1, HLA-DQB1, HLA-DRB1
39pseudopterygium9.9HLA-DQA1, HLA-DQB1, HLA-DRB1
40bone marrow cancer9.9HLA-DQA1, HLA-DQB1, HLA-DRB1
41hypersensitivity reaction type iii disease9.9HLA-DQA1, HLA-DQB1, HLA-DRB1
42bacillary angiomatosis9.9HLA-DQA1, HLA-DQB1, HLA-DRB1
43tularemia9.8HLA-DQA1, HLA-DQB1, HLA-DRB1
44red cell phospholipid defect with hemolysis9.8HLA-DQB1, HLA-DRB1, IFNA2
45papillary adenocarcinoma9.8HLA-DQB1, HLA-DRB1, IFNA2
46limited scleroderma9.8HLA-DQB1, HLA-DRB1, IFNA2
47systemic lupus erythematosus9.7HLA-DQA1, HLA-DQB1, HLA-DRB1
48rheumatoid arthritis9.7HLA-DQA1, HLA-DQB1, HLA-DRB1
49diabetes mellitus, insulin-dependent9.6HLA-DQA1, HLA-DQB1, HLA-DRB1
50testicular monophasic choriocarcinoma9.3HLA-DQA1, HLA-DQB1, HLA-DRB1, IFNA2, MTFMT

Graphical network of the top 20 diseases related to Focal Epithelial Hyperplasia:



Diseases related to focal epithelial hyperplasia

Symptoms for Focal Epithelial Hyperplasia

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Symptoms:

 10
  • papules or nodules in the oral cavity

Drugs & Therapeutics for Focal Epithelial Hyperplasia

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Interventional clinical trials:

idNameStatusNCT IDPhase
1Quantitative Real-time Ultrasound Elastography for Characterisation of Liver TumorsCompletedNCT02156700
2Risk Factors for Concurrent Endometrial Carcinoma in Patients With a Curettage Diagnosis of Endometrial HyperplasiaRecruitingNCT01273636

Search NIH Clinical Center for Focal Epithelial Hyperplasia


Cochrane evidence based reviews: Focal Epithelial Hyperplasia

Genetic Tests for Focal Epithelial Hyperplasia

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Anatomical Context for Focal Epithelial Hyperplasia

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MalaCards organs/tissues related to Focal Epithelial Hyperplasia:

33
Tongue

FMA organs/tissues related to Focal Epithelial Hyperplasia:

16
Mouth

Animal Models for Focal Epithelial Hyperplasia or affiliated genes

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Publications for Focal Epithelial Hyperplasia

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Articles related to Focal Epithelial Hyperplasia:

(show top 50)    (show all 145)
idTitleAuthorsYear
1
Extensive Focal Epithelial Hyperplasia: A Case Report. (26351501)
2015
2
Molecular Biology for HPV Typing in Focal Epithelial Hyperplasia. (26456971)
2015
3
Focal epithelial hyperplasia (Heck's disease) in two Chinese females. (22154527)
2012
4
A Case Report of Focal Epithelial Hyperplasia (Heck's disease) with PCR Detection of Human Papillomavirus. (23204755)
2011
5
Oral focal epithelial hyperplasia. (20863043)
2010
6
Focal epithelial hyperplasia (Heck disease) related to highly active antiretroviral therapy in an HIV-seropositive child. A report of a case, and a review of the literature. (20632701)
2010
7
Focal epithelial hyperplasia: polymerase chain reaction amplification as a differential diagnosis tool. (19155739)
2009
8
Case of the month. Heck's disease (focal epithelial hyperplasia). (19405233)
2009
9
What is your diagnosis? Focal epithelial hyperplasia (Heck disease). (16706237)
2006
10
Molecular and serological evidence of the epidemiological association of HPV 13 with focal epithelial hyperplasia: a case-control study. (16793332)
2006
11
Extensive focal epithelial hyperplasia: case report. (16324231)
2005
12
Oral pathology quiz #48. Case number 2. Focal epithelial hyperplasia. (16795955)
2005
13
Association of HLA-DR4 (DRB1*0404) with human papillomavirus infection in patients with focal epithelial hyperplasia. (15492185)
2004
14
Focal epithelial hyperplasia: report of six cases from Ghana, West Africa. (12413174)
2002
15
Focal epithelial hyperplasia (Heck's disease). (11526896)
2001
16
Focal epithelial hyperplasia: a multifocal oral human papillomavirus infection. (10769863)
2000
17
Focal epithelial hyperplasia in an Ecuadorian girl. (10626102)
1999
18
Focal epithelial hyperplasia in an HIV positive man. An illustrated case and review of the literature. (9848979)
1998
19
Focal epithelial hyperplasia. (7838556)
1995
20
Occurrence and resolution of focal epithelial hyperplasia in two siblings with leukocyte adhesion deficiency. (8433256)
1993
21
In situ hybridization with digoxigenin-labelled DNA probes for the detection of human papillomavirus-induced focal epithelial hyperplasia among Venezuelans. (1314447)
1992
22
Human papillomavirus (HPV) DNA in focal epithelial hyperplasia by in situ hybridization. (1648613)
1991
23
Focal epithelial hyperplasia (Heck's disease): the first reported case from Italy. (1850180)
1991
24
Focal epithelial hyperplasia (Heck's disease) in a Sudanese girl: case report. (2612415)
1989
25
Focal epithelial hyperplasia: report of two cases and review of literature. (3466937)
1986
26
Focal epithelial hyperplasia: first report in MAcxico. Clinical, light and ultrastructural microscopic studies. (3592890)
1986
27
Immunohistochemical evidence of papillomavirus antigen in focal epithelial hyperplasia. (3006275)
1985
28
Focal epithelial hyperplasia (Heck's disease). A case report. (3856655)
1985
29
A human papillomavirus closely related to HPV 13 found in a focal epithelial hyperplasia lesion (Heck disease). (6089671)
1984
30
Focal epithelial hyperplasia. Report of nine cases from Sweden and review of the literature. (6587302)
1984
31
Focal epithelial hyperplasia (Hecks' disease) in a Sudanese boy. Report of a case and review of literature. (6579515)
1983
32
Characterization of human papillomavirus type 13 from focal epithelial hyperplasia Heck lesions. (6312071)
1983
33
Focal epithelial hyperplasia. Report of three cases from Nigeria, West Africa. (6578481)
1983
34
Focal epithelial hyperplasia in Sweden. (6948491)
1981
35
Focal epithelial hyperplasia. (6941143)
1981
36
HPV 1 DNA in lesions of focal epithelial hyperplasia Heck. (6260042)
1980
37
Focal epithelial hyperplasia of the oral mucosa. A case report from the United Kingdom. (228693)
1979
38
Focal epithelial hyperplasia in Abu Dhabi. (277855)
1978
39
Focal epithelial hyperplasia in Israeli families of Libyan origin. (277883)
1978
40
Focal epithelial hyperplasia (Heck's disease). (271558)
1977
41
Focal epithelial hyperplasia. Report of five new cases from Argentina. (1057126)
1975
42
Focal epithelial hyperplasia in the oral mucosa of a chimpanzee. (4742089)
1973
43
Focal epithelial hyperplasia in an Eskimo population. (4500597)
1972
44
Focal epithelial hyperplasia: a virus-induced oral mucosal lesion in the chimpanzee. (4500596)
1972
45
Focal epithelial hyperplasia. A light and electron microscopic study of one case. (4503460)
1972
46
Focal epithelial hyperplasia. Report of a case in a South African Caucasoid. (5282068)
1971
47
Focal epithelial hyperplasia. Report of seven cases from Iraq. (5277369)
1971
48
Focal epithelial hyperplasia: report of a case in an Australian aborigine. (5286891)
1971
49
Focal epithelial hyperplasia in a half-breed family of Colombians. (5256372)
1969
50
Focal epithelial hyperplasia. Report of a case. (5245681)
1968

Variations for Focal Epithelial Hyperplasia

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Expression for genes affiliated with Focal Epithelial Hyperplasia

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Search GEO for disease gene expression data for Focal Epithelial Hyperplasia.

Pathways for genes affiliated with Focal Epithelial Hyperplasia

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Pathways related to Focal Epithelial Hyperplasia according to GeneCards Suite gene sharing:

(show all 21)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
TCR signaling (REACTOME)
Show member pathways
8.5
28.5HLA-DQA1, HLA-DQB1, HLA-DRB1
3
Show member pathways
8.5HLA-DQA1, HLA-DQB1, HLA-DRB1
4
Show member pathways
8.5HLA-DQA1, HLA-DQB1, HLA-DRB1
5
Show member pathways
8.5HLA-DQA1, HLA-DQB1, HLA-DRB1
68.5HLA-DQA1, HLA-DQB1, HLA-DRB1
7
Show member pathways
8.5HLA-DQA1, HLA-DQB1, HLA-DRB1
8
TCR Signaling (Qiagen)
Show member pathways
8.5HLA-DQA1, HLA-DQB1, HLA-DRB1
9
Show member pathways
8.5HLA-DQA1, HLA-DQB1, HLA-DRB1
10
Show member pathways
8.5HLA-DQA1, HLA-DQB1, HLA-DRB1
118.5HLA-DQA1, HLA-DQB1, HLA-DRB1
128.5HLA-DQA1, HLA-DQB1, HLA-DRB1
138.5HLA-DQA1, HLA-DQB1, HLA-DRB1
148.5HLA-DQA1, HLA-DQB1, HLA-DRB1
15
Show member pathways
8.5HLA-DQA1, HLA-DQB1, HLA-DRB1
168.5HLA-DQA1, HLA-DQB1, HLA-DRB1
178.5HLA-DQA1, HLA-DQB1, HLA-DRB1
18
Show member pathways
8.1HLA-DQA1, HLA-DQB1, HLA-DRB1, IFNA2
19
Show member pathways
8.1HLA-DQA1, HLA-DQB1, HLA-DRB1, IFNA2
20
Show member pathways
8.1HLA-DQA1, HLA-DQB1, HLA-DRB1, IFNA2
218.1HLA-DQA1, HLA-DQB1, HLA-DRB1, IFNA2

GO Terms for genes affiliated with Focal Epithelial Hyperplasia

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Cellular components related to Focal Epithelial Hyperplasia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1MHC class II protein complexGO:00426138.9HLA-DQA1, HLA-DQB1, HLA-DRB1
2integral component of lumenal side of endoplasmic reticulum membraneGO:00715568.9HLA-DQA1, HLA-DQB1, HLA-DRB1
3ER to Golgi transport vesicle membraneGO:00125078.9HLA-DQA1, HLA-DQB1, HLA-DRB1
4endocytic vesicle membraneGO:00306668.9HLA-DQA1, HLA-DQB1, HLA-DRB1
5clathrin-coated endocytic vesicle membraneGO:00306698.8HLA-DQA1, HLA-DQB1, HLA-DRB1
6trans-Golgi network membraneGO:00325888.8HLA-DQA1, HLA-DQB1, HLA-DRB1
7lysosomal membraneGO:00057658.6HLA-DQA1, HLA-DQB1, HLA-DRB1
8Golgi membraneGO:00001398.5HLA-DQA1, HLA-DQB1, HLA-DRB1
9transport vesicle membraneGO:00306588.4HLA-DQA1, HLA-DQB1, HLA-DRB1

Biological processes related to Focal Epithelial Hyperplasia according to GeneCards Suite gene sharing:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1immunoglobulin production involved in immunoglobulin mediated immune responseGO:00023819.9HLA-DQB1, HLA-DRB1
2humoral immune response mediated by circulating immunoglobulinGO:00024559.8HLA-DQB1, HLA-DRB1
3antigen processing and presentation of peptide or polysaccharide antigen via MHC class IIGO:00025049.1HLA-DQA1, HLA-DQB1, HLA-DRB1
4interferon-gamma-mediated signaling pathwayGO:00603339.0HLA-DQA1, HLA-DQB1, HLA-DRB1
5T cell costimulationGO:00312958.9HLA-DQA1, HLA-DQB1, HLA-DRB1
6antigen processing and presentationGO:00198828.9HLA-DQA1, HLA-DQB1, HLA-DRB1
7T cell receptor signaling pathwayGO:00508528.9HLA-DQA1, HLA-DQB1, HLA-DRB1
8antigen processing and presentation of exogenous peptide antigen via MHC class IIGO:00198868.6HLA-DQA1, HLA-DQB1, HLA-DRB1
9immune responseGO:00069558.4HLA-DQA1, HLA-DQB1, HLA-DRB1
10cytokine-mediated signaling pathwayGO:00192218.1HLA-DQA1, HLA-DQB1, HLA-DRB1, IFNA2

Molecular functions related to Focal Epithelial Hyperplasia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1MHC class II receptor activityGO:00323958.7HLA-DQA1, HLA-DQB1, HLA-DRB1
2peptide antigen bindingGO:00426058.5HLA-DQA1, HLA-DQB1, HLA-DRB1

Sources for Focal Epithelial Hyperplasia

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet