MCID: FCL010
MIFTS: 37

Focal Epithelial Hyperplasia

Categories: Infectious diseases

Aliases & Classifications for Focal Epithelial Hyperplasia

MalaCards integrated aliases for Focal Epithelial Hyperplasia:

Name: Focal Epithelial Hyperplasia 12 51 41 14 69
Multifocal Epithelial Hyperplasia 12
Heck's Disease 12
Heck Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5362
MeSH 41 D017573
NCIt 46 C97083
SNOMED-CT 64 36949004 6121001
UMLS 69 C0206067

Summaries for Focal Epithelial Hyperplasia

Disease Ontology : 12 A viral infectious disease that results_in infection located in mouth, has material basis in human papillomavirus (types 13 or 32), has symptom papules or nodules in the oral cavity.

MalaCards based summary : Focal Epithelial Hyperplasia, also known as multifocal epithelial hyperplasia, is related to focal epithelial hyperplasia, oral and focal epithelial hyperplasia of the oral mucosa, and has symptoms including papules or nodules in the oral cavity and oral manifestations. An important gene associated with Focal Epithelial Hyperplasia is HLA-DRB1 (Major Histocompatibility Complex, Class II, DR Beta 1), and among its related pathways/superpathways are Actin Nucleation by ARP-WASP Complex and TCR Signaling (Qiagen). Affiliated tissues include mouth and tongue.

Wikipedia : 72 Heck\'s disease (also known as focal or multifocal epithelial hyperplasia) is an asymptomatic, benign... more...

Related Diseases for Focal Epithelial Hyperplasia

Diseases related to Focal Epithelial Hyperplasia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 59)
# Related Disease Score Top Affiliating Genes
1 focal epithelial hyperplasia, oral 12.4
2 focal epithelial hyperplasia of the oral mucosa 12.3
3 eosinophilia-myalgia syndrome 10.2 HLA-DQA1 HLA-DRB1
4 sympathetic ophthalmia 10.2 HLA-DQA1 HLA-DRB1
5 limbic encephalitis with lgi1 antibodies 10.1 HLA-DQB1 HLA-DRB1
6 metal allergy 10.1 HLA-DQB1 HLA-DRB1
7 lichen planopilaris 10.1 HLA-DQB1 HLA-DRB1
8 type ii mixed cryoglobulinemia 10.1 HLA-DQB1 HLA-DRB1
9 idiopathic inflammatory myopathy 10.1 HLA-DQB1 HLA-DRB1
10 chronic beryllium disease 10.1 HLA-DQB1 HLA-DRB1
11 autoimmune pancreatitis 10.1 HLA-DQB1 HLA-DRB1
12 pityriasis rosea 10.1 HLA-DQB1 HLA-DRB1
13 lichen sclerosus 10.1 HLA-DQB1 HLA-DRB1
14 whipple disease 10.1 HLA-DQB1 HLA-DRB1
15 rheumatic heart disease 10.1 HLA-DQA1 HLA-DRB1
16 pediatric multiple sclerosis 10.1 HLA-DQB1 HLA-DRB1
17 osteonecrosis of the jaw 10.1 HLA-DQB1 HLA-DRB1
18 microscopic colitis 10.1 HLA-DQB1 HLA-DRB1
19 cystic echinococcosis 10.1 HLA-DQB1 HLA-DRB1
20 achalasia, familial esophageal 10.1 HLA-DQA1 HLA-DQB1
21 peanut allergy 10.1 HLA-DQB1 HLA-DRB1
22 panuveitis 10.1 HLA-DQB1 HLA-DRB1
23 juvenile rheumatoid arthritis 10.0 HLA-DQA1 HLA-DRB1
24 hypersomnia 10.0 HLA-DQB1 HLA-DRB1
25 geographic tongue 10.0 HLA-DQB1 HLA-DRB1
26 congenital toxoplasmosis 10.0 HLA-DQA1 HLA-DQB1
27 severe hemophilia a 10.0 HLA-DQB1 HLA-DRB1
28 ocular cicatricial pemphigoid 10.0 HLA-DQB1 HLA-DRB1
29 paraneoplastic pemphigus 10.0 HLA-DQB1 HLA-DRB1
30 cervical dystonia 10.0 HLA-DQA1 HLA-DQB1
31 endometritis 10.0 HLA-DQA1 HLA-DQB1
32 vogt-koyanagi-harada disease 10.0 HLA-DQB1 HLA-DRB1
33 leishmaniasis 10.0 HLA-DQA1 HLA-DRB1
34 dermatitis herpetiformis 10.0 HLA-DQA1 HLA-DQB1
35 mucositis 10.0
36 papilloma 10.0
37 graft-versus-host disease 10.0 HLA-DQB1 HLA-DRB1
38 autoimmune hepatitis 9.9 HLA-DQB1 HLA-DRB1
39 toxoplasmosis 9.9 HLA-DQA1 HLA-DQB1
40 bullous pemphigoid 9.9 HLA-DQB1 HLA-DRB1
41 celiac disease 1 9.8 HLA-DQA1 HLA-DQB1
42 connective tissue disease 9.8 HLA-DQA1 HLA-DRB1
43 beryllium disease 9.7 HLA-DQA1 HLA-DQB1 HLA-DRB1
44 recurrent respiratory papillomatosis 9.7 HLA-DQA1 HLA-DQB1 HLA-DRB1
45 leukocyte adhesion deficiency, type i 9.7
46 keratoacanthoma 9.7
47 molluscum contagiosum 9.7
48 acute disseminated encephalomyelitis 9.7 HLA-DQA1 HLA-DQB1 HLA-DRB1
49 idiopathic bronchiectasis 9.7 HLA-DQA1 HLA-DQB1 HLA-DRB1
50 oligoarticular juvenile idiopathic arthritis 9.7 HLA-DQA1 HLA-DQB1 HLA-DRB1

Graphical network of the top 20 diseases related to Focal Epithelial Hyperplasia:



Diseases related to Focal Epithelial Hyperplasia

Symptoms & Phenotypes for Focal Epithelial Hyperplasia

Symptoms:

12
  • papules or nodules in the oral cavity

UMLS symptoms related to Focal Epithelial Hyperplasia:


oral manifestations

Drugs & Therapeutics for Focal Epithelial Hyperplasia

Search Clinical Trials , NIH Clinical Center for Focal Epithelial Hyperplasia

Cochrane evidence based reviews: focal epithelial hyperplasia

Genetic Tests for Focal Epithelial Hyperplasia

Anatomical Context for Focal Epithelial Hyperplasia

The Foundational Model of Anatomy Ontology organs/tissues related to Focal Epithelial Hyperplasia:

18
Mouth

MalaCards organs/tissues related to Focal Epithelial Hyperplasia:

38
Tongue

Publications for Focal Epithelial Hyperplasia

Articles related to Focal Epithelial Hyperplasia:

(show top 50) (show all 151)
# Title Authors Year
1
Pediatric Dermatology Photoquiz: Multiple Papules on the Mucosal Surfaces of a 17-Year-Old Boy. Focal epithelial hyperplasia (Heck's disease). ( 26758095 )
2016
2
Focal Epithelial Hyperplasia (Heck's Disease) in a 57-Year-Old Brazilian Patient: A Case Report and Literature Review. ( 26985258 )
2016
3
Case Report of Focal Epithelial Hyperplasia (Heck's Disease) with Polymerase Chain Reaction Detection of Human Papillomavirus 13. ( 27882674 )
2016
4
Focal Epithelial Hyperplasia in Adult Patients With HIV Infection: Clearance With Topical Imiquimod. ( 27871359 )
2016
5
Case Report of Focal Epithelial Hyperplasia (Heck's Disease) with Polymerase Chain Reaction Detection of Human Papillomavirus 13. ( 27072123 )
2016
6
Molecular Biology for HPV Typing in Focal Epithelial Hyperplasia. ( 26456971 )
2015
7
Focal epithelial hyperplasia by human papillomavirus (HPV)-32 misdiagnosed as HPV-16 and treated with combination of retinoids, imiquimod and quadrivalent HPV vaccine. ( 26047065 )
2015
8
Extensive Focal Epithelial Hyperplasia: A Case Report. ( 26351501 )
2015
9
Oral Focal Epithelial Hyperplasia: Report of Three Cases. ( 24585348 )
2014
10
Focal epithelial hyperplasia (Heck's disease): a case report and review. ( 24706245 )
2014
11
Focal epithelial hyperplasia in a human immuno-deficiency virus patient treated with laser surgery. ( 25032206 )
2014
12
Focal epithelial hyperplasia arising after delivery of metal-ceramic fixed dental prosthesis. ( 25558348 )
2014
13
Focal epithelial hyperplasia in a Turkish family. ( 25551850 )
2014
14
Focal epithelial hyperplasia associated with human papillomavirus 13 and common human leukocyte antigen alleles in a Turkish family. ( 24738569 )
2014
15
Focal epithelial hyperplasia. ( 24269109 )
2013
16
Focal epithelial hyperplasia - an update. ( 23061874 )
2013
17
Focal epithelial hyperplasia (Heck's disease). ( 24353818 )
2013
18
Human papillomavirus-32-associated focal epithelial hyperplasia accompanying HPV-16-positive papilloma-like lesions in oral mucosa. ( 23714908 )
2013
19
Focal epithelial hyperplasia (Heck's disease) in two Chinese females. ( 22154527 )
2012
20
Oral medicine case book 43--focal epithelial hyperplasia in an HIV-seropositive child. ( 23951749 )
2012
21
Focal epithelial hyperplasia: Case report. ( 22071419 )
2011
22
Oral focal epithelial hyperplasia: report of 3 cases with human papillomavirus DNA sequencing analysis. ( 22353414 )
2011
23
A Case Report of Focal Epithelial Hyperplasia (Heck's disease) with PCR Detection of Human Papillomavirus. ( 23204755 )
2011
24
Dermacase. Can you identify this condition? Focal epithelial hyperplasia. ( 22170197 )
2011
25
Oral focal epithelial hyperplasia. ( 20863043 )
2010
26
Focal epithelial hyperplasia caused by human papillomavirus 13. ( 20508479 )
2010
27
Focal epithelial hyperplasia (Heck disease) related to highly active antiretroviral therapy in an HIV-seropositive child. A report of a case, and a review of the literature. ( 20632701 )
2010
28
Focal epithelial hyperplasia (Heck's Disease) in two siblings: response to treatment with imiquimod 5% cream. ( 20172842 )
2010
29
Extensive focal epithelial hyperplasia. ( 20039770 )
2010
30
Case of the month. Heck's disease (focal epithelial hyperplasia). ( 19405233 )
2009
31
Induction of focal epithelial hyperplasia in tongue of young bk6-E6/E7 HPV16 transgenic mice. ( 19165615 )
2009
32
Detection of human papilloma virus DNA in seven cases of focal epithelial hyperplasia in Iran. ( 19453844 )
2009
33
Treatment of focal epithelial hyperplasia with topical imiquimod: report of three cases. ( 19689526 )
2009
34
Focal epithelial hyperplasia: polymerase chain reaction amplification as a differential diagnosis tool. ( 19155739 )
2009
35
An uncommon focal epithelial hyperplasia manifestation. ( 19941767 )
2009
36
Focal epithelial hyperplasia (Heck disease) in a black child. ( 17845152 )
2007
37
What is your diagnosis? Focal epithelial hyperplasia (Heck disease). ( 16706237 )
2006
38
Oral focal epithelial hyperplasia: report of five cases. ( 16721472 )
2006
39
Focal epithelial hyperplasia (Heck's disease): report of a case in a girl of Brazilian Indian descent. ( 16364096 )
2006
40
Oral pathology quiz #51. Case number 4. Focal epithelial hyperplasia. ( 16800060 )
2006
41
Molecular and serological evidence of the epidemiological association of HPV 13 with focal epithelial hyperplasia: a case-control study. ( 16793332 )
2006
42
General practitioner's pathology case 9. Focal epithelial hyperplasia. ( 17201309 )
2006
43
Extensive focal epithelial hyperplasia: case report. ( 16324231 )
2005
44
Focal epithelial hyperplasia. A rare disease in our area. ( 15735545 )
2005
45
Clinical, histopathological and virological findings in patients with focal epithelial hyperplasia from Colombia. ( 15811076 )
2005
46
Oral pathology quiz #48. Case number 2. Focal epithelial hyperplasia. ( 16795955 )
2005
47
Oral pathology quiz # 42. Case 1. Focal epithelial hyperplasia. ( 15160430 )
2004
48
Association of HLA-DR4 (DRB1*0404) with human papillomavirus infection in patients with focal epithelial hyperplasia. ( 15492185 )
2004
49
Focal epithelial hyperplasia (Heck's disease): report of two cases with PCR detection of human papillomavirus DNA. ( 15196147 )
2004
50
Focal epithelial hyperplasia: report of six cases from Ghana, West Africa. ( 12413174 )
2002

Variations for Focal Epithelial Hyperplasia

Expression for Focal Epithelial Hyperplasia

Search GEO for disease gene expression data for Focal Epithelial Hyperplasia.

Pathways for Focal Epithelial Hyperplasia

Pathways related to Focal Epithelial Hyperplasia according to GeneCards Suite gene sharing:

(show all 24)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.63 HLA-DQA1 HLA-DQB1 HLA-DRB1
2
Show member pathways
12.56 HLA-DQA1 HLA-DQB1 HLA-DRB1
3
Show member pathways
12.52 HLA-DQA1 HLA-DQB1 HLA-DRB1
4
Show member pathways
12.47 HLA-DQA1 HLA-DQB1 HLA-DRB1
5
Show member pathways
12.33 HLA-DQA1 HLA-DQB1 HLA-DRB1
6
Show member pathways
12.3 HLA-DQA1 HLA-DQB1 HLA-DRB1
7
Show member pathways
12.24 HLA-DQA1 HLA-DQB1 HLA-DRB1
8 12.15 HLA-DQA1 HLA-DQB1 HLA-DRB1
9
Show member pathways
12.11 HLA-DQA1 HLA-DQB1 HLA-DRB1
10
Show member pathways
12.07 HLA-DQA1 HLA-DQB1 HLA-DRB1
11 12.02 HLA-DQA1 HLA-DQB1 HLA-DRB1
12
Show member pathways
11.97 HLA-DQA1 HLA-DQB1 HLA-DRB1
13 11.94 HLA-DQA1 HLA-DQB1 HLA-DRB1
14
Show member pathways
11.91 HLA-DQA1 HLA-DQB1 HLA-DRB1
15 11.84 HLA-DQA1 HLA-DQB1 HLA-DRB1
16 11.77 HLA-DQA1 HLA-DQB1 HLA-DRB1
17
Show member pathways
11.62 HLA-DQA1 HLA-DQB1 HLA-DRB1
18 11.61 HLA-DQA1 HLA-DQB1 HLA-DRB1
19 11.56 HLA-DQA1 HLA-DQB1 HLA-DRB1
20 11.48 HLA-DQA1 HLA-DQB1 HLA-DRB1
21 11.39 HLA-DQA1 HLA-DQB1 HLA-DRB1
22 11.18 HLA-DQA1 HLA-DQB1 HLA-DRB1
23 10.88 HLA-DQA1 HLA-DQB1 HLA-DRB1
24
Show member pathways
10.76 HLA-DQA1 HLA-DQB1 HLA-DRB1

GO Terms for Focal Epithelial Hyperplasia

Cellular components related to Focal Epithelial Hyperplasia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Golgi membrane GO:0000139 9.65 HLA-DQA1 HLA-DQB1 HLA-DRB1
2 lysosomal membrane GO:0005765 9.63 HLA-DQA1 HLA-DQB1 HLA-DRB1
3 endosome membrane GO:0010008 9.61 HLA-DQA1 HLA-DQB1 HLA-DRB1
4 trans-Golgi network membrane GO:0032588 9.58 HLA-DQA1 HLA-DQB1 HLA-DRB1
5 endocytic vesicle membrane GO:0030666 9.54 HLA-DQA1 HLA-DQB1 HLA-DRB1
6 ER to Golgi transport vesicle membrane GO:0012507 9.5 HLA-DQA1 HLA-DQB1 HLA-DRB1
7 transport vesicle membrane GO:0030658 9.43 HLA-DQA1 HLA-DQB1 HLA-DRB1
8 clathrin-coated endocytic vesicle membrane GO:0030669 9.33 HLA-DQA1 HLA-DQB1 HLA-DRB1
9 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 9.13 HLA-DQA1 HLA-DQB1 HLA-DRB1
10 MHC class II protein complex GO:0042613 8.8 HLA-DQA1 HLA-DQB1 HLA-DRB1

Biological processes related to Focal Epithelial Hyperplasia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.63 HLA-DQA1 HLA-DQB1 HLA-DRB1
2 T cell receptor signaling pathway GO:0050852 9.61 HLA-DQA1 HLA-DQB1 HLA-DRB1
3 antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0019886 9.58 HLA-DQA1 HLA-DQB1 HLA-DRB1
4 T cell costimulation GO:0031295 9.5 HLA-DQA1 HLA-DQB1 HLA-DRB1
5 interferon-gamma-mediated signaling pathway GO:0060333 9.43 HLA-DQA1 HLA-DQB1 HLA-DRB1
6 humoral immune response mediated by circulating immunoglobulin GO:0002455 9.37 HLA-DQB1 HLA-DRB1
7 immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 9.16 HLA-DQB1 HLA-DRB1
8 antigen processing and presentation GO:0019882 9.13 HLA-DQA1 HLA-DQB1 HLA-DRB1
9 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 8.8 HLA-DQA1 HLA-DQB1 HLA-DRB1

Molecular functions related to Focal Epithelial Hyperplasia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptide antigen binding GO:0042605 9.13 HLA-DQA1 HLA-DQB1 HLA-DRB1
2 MHC class II receptor activity GO:0032395 8.8 HLA-DQA1 HLA-DQB1 HLA-DRB1

Sources for Focal Epithelial Hyperplasia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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