MCID: FCL010
MIFTS: 34

Focal Epithelial Hyperplasia malady

Infectious diseases, Oral diseases categories
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Summaries for Focal Epithelial Hyperplasia

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Disease Ontology:8 A viral infectious disease that results in infection located in mouth, has material basis in human papillomavirus (types 13 or 32), has symptom papules or nodules in the oral cavity.

MalaCards based summary: Focal Epithelial Hyperplasia, also known as multifocal epithelial hyperplasia, is related to papilloma and polyarteritis nodosa, and has symptoms including An important gene associated with Focal Epithelial Hyperplasia is IFNA2 (interferon, alpha 2), and among its related pathways are Influenza A and Interferon Signaling. The compounds valine and tyrosine have been mentioned in the context of this disorder. Affiliated tissues include mouth and tongue.

Wikipedia:65 Heck\'s disease (also known as focal epithelial hyperplasia) is a condition characterized by white to... more...

Description from OMIM:46 229045

Aliases & Classifications for Focal Epithelial Hyperplasia

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Sources:
8Disease Ontology, 44Novoseek, 62UMLS, 46OMIM, 57SNOMED-CT, 34MeSH
See all sources

Focal Epithelial Hyperplasia, Aliases & Descriptions:

Name: Focal Epithelial Hyperplasia 8 44 62
Multifocal Epithelial Hyperplasia 8 62
 
Heck's Disease 8
Heck Disease 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases
Anatomical: Oral diseases


External Ids:

Disease Ontology8 DOID:5362
OMIM46 229045
SNOMED-CT57 36949004, 6121001
MeSH34 D017573

Related Diseases for Focal Epithelial Hyperplasia

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Diseases related to Focal Epithelial Hyperplasia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 16)
idRelated DiseaseScoreTop Affiliating Genes
1papilloma10.4
2polyarteritis nodosa10.2IFNA2
3leukocyte adhesion deficiency10.2
4molluscum contagiosum10.2
5keratoacanthoma10.2
6sarcoidosis10.2
7autoimmune thrombocytopenic purpura10.0IFNA2, HLA-DRB1
8viral hepatitis10.0HLA-DRB1, IFNA2
9hepatitis10.0IFNA2, HLA-DRB1
10liver cirrhosis9.9HLA-DRB1, IFNA2
11hepatitis b9.9IFNA2, HLA-DRB1
12hepatitis c9.9IFNA2, HLA-DRB1
13galactosemia9.9HLA-DRB1, IFNA2
14leukemia9.9IFNA2, HLA-DRB1
15liver cancer9.8IFNA2, HLA-DRB1
16melanoma9.8IFNA2, HLA-DRB1

Graphical network of diseases related to Focal Epithelial Hyperplasia:



Diseases related to focal epithelial hyperplasia

Symptoms for Focal Epithelial Hyperplasia

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Clinical features from OMIM:

229045

Drugs & Therapeutics for Focal Epithelial Hyperplasia

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Drug clinical trials:

Search ClinicalTrials for Focal Epithelial Hyperplasia

Search NIH Clinical Center for Focal Epithelial Hyperplasia

Genetic Tests for Focal Epithelial Hyperplasia

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Anatomical Context for Focal Epithelial Hyperplasia

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MalaCards organs/tissues related to Focal Epithelial Hyperplasia:

32
Tongue

FMA organs/tissues related to Focal Epithelial Hyperplasia:

14
Mouth

Animal Models for Focal Epithelial Hyperplasia or affiliated genes

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Publications for Focal Epithelial Hyperplasia

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Articles related to Focal Epithelial Hyperplasia:

(show top 50)    (show all 140)
idTitleAuthorsYear
1
Focal epithelial hyperplasia (Heck's disease) in two Chinese females. (22154527)
2012
2
A Case Report of Focal Epithelial Hyperplasia (Heck's disease) with PCR Detection of Human Papillomavirus. (23204755)
2011
3
Focal epithelial hyperplasia: Case report. (22071419)
2011
4
Oral focal epithelial hyperplasia. (20863043)
2010
5
Focal epithelial hyperplasia (Heck disease) related to highly active antiretroviral therapy in an HIV-seropositive child. A report of a case, and a review of the literature. (20632701)
2010
6
Focal epithelial hyperplasia: polymerase chain reaction amplification as a differential diagnosis tool. (19155739)
2009
7
Case of the month. Heck's disease (focal epithelial hyperplasia). (19405233)
2009
8
What is your diagnosis? Focal epithelial hyperplasia (Heck disease). (16706237)
2006
9
Molecular and serological evidence of the epidemiological association of HPV 13 with focal epithelial hyperplasia: a case-control study. (16793332)
2006
10
Extensive focal epithelial hyperplasia: case report. (16324231)
2005
11
Oral pathology quiz #48. Case number 2. Focal epithelial hyperplasia. (16795955)
2005
12
Association of HLA-DR4 (DRB1*0404) with human papillomavirus infection in patients with focal epithelial hyperplasia. (15492185)
2004
13
Focal epithelial hyperplasia: report of six cases from Ghana, West Africa. (12413174)
2002
14
Focal epithelial hyperplasia (Heck's disease). (11526896)
2001
15
Focal epithelial hyperplasia: a multifocal oral human papillomavirus infection. (10769863)
2000
16
Focal epithelial hyperplasia in an Ecuadorian girl. (10626102)
1999
17
Focal epithelial hyperplasia in an HIV positive man. An illustrated case and review of the literature. (9848979)
1998
18
Focal epithelial hyperplasia. (7838556)
1995
19
Occurrence and resolution of focal epithelial hyperplasia in two siblings with leukocyte adhesion deficiency. (8433256)
1993
20
In situ hybridization with digoxigenin-labelled DNA probes for the detection of human papillomavirus-induced focal epithelial hyperplasia among Venezuelans. (1314447)
1992
21
Human papillomavirus (HPV) DNA in focal epithelial hyperplasia by in situ hybridization. (1648613)
1991
22
Focal epithelial hyperplasia (Heck's disease): the first reported case from Italy. (1850180)
1991
23
Focal epithelial hyperplasia (Heck's disease) in a Sudanese girl: case report. (2612415)
1989
24
Focal epithelial hyperplasia: report of two cases and review of literature. (3466937)
1986
25
Focal epithelial hyperplasia: first report in MAcxico. Clinical, light and ultrastructural microscopic studies. (3592890)
1986
26
Immunohistochemical evidence of papillomavirus antigen in focal epithelial hyperplasia. (3006275)
1985
27
Focal epithelial hyperplasia (Heck's disease). A case report. (3856655)
1985
28
A human papillomavirus closely related to HPV 13 found in a focal epithelial hyperplasia lesion (Heck disease). (6089671)
1984
29
Focal epithelial hyperplasia. Report of nine cases from Sweden and review of the literature. (6587302)
1984
30
Focal epithelial hyperplasia (Hecks' disease) in a Sudanese boy. Report of a case and review of literature. (6579515)
1983
31
Characterization of human papillomavirus type 13 from focal epithelial hyperplasia Heck lesions. (6312071)
1983
32
Focal epithelial hyperplasia. Report of three cases from Nigeria, West Africa. (6578481)
1983
33
Focal epithelial hyperplasia in Sweden. (6948491)
1981
34
Focal epithelial hyperplasia. (6941143)
1981
35
Focal epithelial hyperplasia. The first reported case from Greece. (7262382)
1981
36
HPV 1 DNA in lesions of focal epithelial hyperplasia Heck. (6260042)
1980
37
Focal epithelial hyperplasia of the oral mucosa. A case report from the United Kingdom. (228693)
1979
38
Focal epithelial hyperplasia in Abu Dhabi. (277855)
1978
39
Focal epithelial hyperplasia in Israeli families of Libyan origin. (277883)
1978
40
Focal epithelial hyperplasia (Heck's disease). (271558)
1977
41
Focal epithelial hyperplasia. Report of five new cases from Argentina. (1057126)
1975
42
Focal epithelial hyperplasia in the oral mucosa of a chimpanzee. (4742089)
1973
43
Focal epithelial hyperplasia in an Eskimo population. (4500597)
1972
44
Focal epithelial hyperplasia: a virus-induced oral mucosal lesion in the chimpanzee. (4500596)
1972
45
Focal epithelial hyperplasia. A light and electron microscopic study of one case. (4503460)
1972
46
Focal epithelial hyperplasia. Report of a case in a South African Caucasoid. (5282068)
1971
47
Focal epithelial hyperplasia. Report of seven cases from Iraq. (5277369)
1971
48
Focal epithelial hyperplasia: report of a case in an Australian aborigine. (5286891)
1971
49
Focal epithelial hyperplasia in a half-breed family of Colombians. (5256372)
1969
50
Focal epithelial hyperplasia. Report of a case. (5245681)
1968

Variations for Focal Epithelial Hyperplasia

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Expression for genes affiliated with Focal Epithelial Hyperplasia

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Expression patterns in normal tissues for genes affiliated with Focal Epithelial Hyperplasia

Search GEO for disease gene expression data for Focal Epithelial Hyperplasia.

Pathways for genes affiliated with Focal Epithelial Hyperplasia

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Compounds for genes affiliated with Focal Epithelial Hyperplasia

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Sources:
44Novoseek
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Compounds related to Focal Epithelial Hyperplasia according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1valine449.1IFNA2, HLA-DRB1
2tyrosine449.1IFNA2, HLA-DRB1
3lysine449.0IFNA2, HLA-DRB1
4alanine448.8IFNA2, HLA-DRB1

GO Terms for genes affiliated with Focal Epithelial Hyperplasia

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Biological processes related to Focal Epithelial Hyperplasia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine-mediated signaling pathwayGO:0192219.1IFNA2, HLA-DRB1

Products for genes affiliated with Focal Epithelial Hyperplasia

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Sources for Focal Epithelial Hyperplasia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet