MCID: FCL010
MIFTS: 29

Focal Epithelial Hyperplasia malady

Summaries for Focal Epithelial Hyperplasia

Sources:
8Disease Ontology, 64Wikipedia, 47OMIM, 33MalaCards
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Disease Ontology:8 A viral infectious disease that results in infection located in mouth, has material basis in human papillomavirus (types 13 or 32), has symptom papules or nodules in the oral cavity.

MalaCards: Focal Epithelial Hyperplasia, also known as multifocal epithelial hyperplasia, is related to molluscum contagiosum and leukocyte adhesion deficiency, and has symptoms including papules or nodules in the oral cavity An important gene associated with Focal Epithelial Hyperplasia is IFNA2 (interferon, alpha 2), and among its related pathways are Interferon Signaling and Tuberculosis. The compounds tamoxifen and histidine have been mentioned in the context of this disorder. Affiliated tissues include mouth and tongue.

Wikipedia:64 Heck\'s disease (also known as focal epithelial hyperplasia) is a cutaneous condition characterized by... more...

Description from OMIM:47 229045

Aliases & Classifications for Focal Epithelial Hyperplasia

Sources:
8Disease Ontology, 45Novoseek, 61UMLS, 35MeSH, 47OMIM, 57SNOMED-CT
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Aliases & Descriptions:

focal epithelial hyperplasia 8 45 61
multifocal epithelial hyperplasia 8
heck's disease 8
heck disease 8


External Ids:

Disease Ontology8 DOID:5362
MeSH35 D017573
SNOMED-CT57 6121001, 36949004
OMIM47 229045

Related Diseases for Focal Epithelial Hyperplasia

Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Focal Epithelial Hyperplasia:



Diseases related to focal epithelial hyperplasia

Clinical Features for Focal Epithelial Hyperplasia

Sources:
47OMIM, 8Disease Ontology
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Clinical features from OMIM:

229045

Symptoms:

8
  • papules or nodules in the oral cavity

Drugs & Therapeutics for Focal Epithelial Hyperplasia

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Focal Epithelial Hyperplasia

Drug clinical trials:

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Search NIH Clinical Center for Focal Epithelial Hyperplasia

Search CenterWatch for Focal Epithelial Hyperplasia

Genetic Tests for Focal Epithelial Hyperplasia

Anatomical Context for Focal Epithelial Hyperplasia

Sources:
14FMA, 33MalaCards
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MalaCards organs/tissues related to Focal Epithelial Hyperplasia:

33
Tongue

FMA organs/tissues related to Focal Epithelial Hyperplasia:

14
Mouth

Animal Models for Focal Epithelial Hyperplasia or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Focal Epithelial Hyperplasia

Sources:
51PubMed
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Articles related to Focal Epithelial Hyperplasia:

(show top 50)    (show all 138)
idTitleAuthorsYear
1
Focal epithelial hyperplasia - an update. (23061874)
2013
2
Human papillomavirus-32-associated focal epithelial hyperplasia accompanying HPV-16-positive papilloma-like lesions in oral mucosa. (23714908)
2013
3
Focal epithelial hyperplasia. (24269109)
2013
4
A Case Report of Focal Epithelial Hyperplasia (Heck's disease) with PCR Detection of Human Papillomavirus. (23204755)
2011
5
Dermacase. Can you identify this condition? Focal epithelial hyperplasia. (22170197)
2011
6
Oral focal epithelial hyperplasia. (20863043)
2010
7
Extensive focal epithelial hyperplasia. (20039770)
2010
8
Focal epithelial hyperplasia: polymerase chain reaction amplification as a differential diagnosis tool. (19155739)
2009
9
An uncommon focal epithelial hyperplasia manifestation. (19941767)
2009
10
Osteopontin as an injury marker expressing in epithelial hyperplasia lesions helpful in prognosis of focal segmental glomerulosclerosis. (17900509)
2007
11
Extensive focal epithelial hyperplasia: case report. (16324231)
2005
12
Oral pathology quiz #48. Case number 2. Focal epithelial hyperplasia. (16795955)
2005
13
Clinical, histopathological and virological findings in patients with focal epithelial hyperplasia from Colombia. (15811076)
2005
14
Oral pathology quiz # 42. Case 1. Focal epithelial hyperplasia. (15160430)
2004
15
Successful topical treatment of focal epithelial hyperplasia (Heck's disease) with interferon-beta. (11359400)
2001
16
Recurrent focal epithelial hyperplasia due to HPV13 in an HIV-positive patient. (11752826)
2001
17
Focal epithelial hyperplasia in an HIV positive man. An illustrated case and review of the literature. (9848979)
1998
18
Focal epithelial hyperplasia. (7838556)
1995
19
Focal epithelial hyperplasia and multifocal human papillomavirus infection in an HIV-seropositive man. (8113468)
1994
20
Occurrence and resolution of focal epithelial hyperplasia in two siblings with leukocyte adhesion deficiency. (8433256)
1993
21
Heck's disease (focal epithelial hyperplasia): a longitudinal study. (8387416)
1993
22
Focal epithelial hyperplasia: human-papillomavirus-induced disease with a genetic predisposition in a Venezuelan family. (8388851)
1993
23
Focal epithelial hyperplasia--a newly discovered disease in north west frontier province of Pakistan. (1433797)
1992
24
Focal epithelial hyperplasia. (1498399)
1992
25
In situ detection of human papillomavirus types 13 and 32 in focal epithelial hyperplasia of the oral mucosa. (2555479)
1989
26
Focal epithelial hyperplasia: report of two cases and review of literature. (3466937)
1986
27
Focal epithelial hyperplasia: first report in MAcxico. Clinical, light and ultrastructural microscopic studies. (3592890)
1986
28
Disturbed expression of ribonucleotide reductase and cytokeratin polypeptides in focal epithelial hyperplasia. An immunohistochemical study using monoclonal antibodies. (2427675)
1986
29
Focal epithelial hyperplasia in a Sudanese girl. (6573454)
1983
30
Focal epithelial hyperplasia in Sweden. (6948491)
1981
31
Focal epithelial hyperplasia. The first reported case from Greece. (7262382)
1981
32
Heck's disease (focal epithelial hyperplasia). (7400412)
1980
33
Focal epithelial hyperplasia of the oral mucosa. A case report from the United Kingdom. (228693)
1979
34
Florid focal epithelial hyperplasia in Fanconi's syndrome. (285722)
1979
35
Focal epithelial hyperplasia in rabbit oral mucosa. (115979)
1979
36
Focal epithelial hyperplasia of the oral mucosa. Report of two cases from the Netherlands and review of the literature. (861173)
1977
37
Focal epithelial hyperplasia. Report of five new cases from Argentina. (1057126)
1975
38
Ultrastructural study of focal epithelial hyperplasia. (163998)
1975
39
Focal epithelial hyperplasia in the oral mucosa of a chimpanzee. (4742089)
1973
40
Geographical aspects of oral focal epithelial hyperplasia. (4718559)
1973
41
Focal epithelial hyperplasia. Report of two cases from Israel and review of literature. (4682549)
1973
42
Focal epithelial hyperplasia with sarcoidosis in an American Negro. (4512748)
1973
43
Focal epithelial hyperplasia in an Eskimo population. (4500597)
1972
44
Focal epithelial hyperplasia: a virus-induced oral mucosal lesion in the chimpanzee. (4500596)
1972
45
Papova virus-like particles in focal epithelial hyperplasia. (4331014)
1971
46
Focal epithelial hyperplasia of the oral mucosa in a south-west Greenlandic population. (5273696)
1970
47
Focal epithelial hyperplasia (Heck's disease). (5276741)
1970
48
Focal epithelial hyperplasia. Case reports from Paraguay and Peru. (5257183)
1969
49
Focal epithelial hyperplasia. Report of a case. (5245681)
1968
50
FOCAL EPITHELIAL HYPERPLASIA IN CENTRAL AND SOUTH AMERICAN INDIANS AND LADINOS. (14319596)
1965

Genetic Variations for Focal Epithelial Hyperplasia

Expression for genes affiliated with Focal Epithelial Hyperplasia

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Focal Epithelial Hyperplasia

Search GEO for disease gene expression data for Focal Epithelial Hyperplasia.

Pathways for genes affiliated with Focal Epithelial Hyperplasia

Sources:
54Reactome, 30KEGG, 52QIAGEN
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Compounds for genes affiliated with Focal Epithelial Hyperplasia

Sources:
45Novoseek, 50PharmGKB, 29IUPHAR, 11DrugBank
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Compounds related to Focal Epithelial Hyperplasia according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1tamoxifen45 50 29 1112.0EPHX1, IFNA2
2histidine458.7EPHX1, IFNA2
3tyrosine458.4EPHX1, HLA-DRB1, IFNA2

GO Terms for genes affiliated with Focal Epithelial Hyperplasia

Sources:
16Gene Ontology
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Biological processes related to Focal Epithelial Hyperplasia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine-mediated signaling pathwayGO:0192219.3HLA-DRB1, IFNA2

Products for genes affiliated with Focal Epithelial Hyperplasia

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Sources for Focal Epithelial Hyperplasia

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet