MCID: FCL010
MIFTS: 38

Focal Epithelial Hyperplasia malady

Categories: Infectious diseases

Aliases & Classifications for Focal Epithelial Hyperplasia

Aliases & Descriptions for Focal Epithelial Hyperplasia:

Name: Focal Epithelial Hyperplasia 12 52 42 14 69
Multifocal Epithelial Hyperplasia 12
Heck's Disease 12
Heck Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5362
MeSH 42 D017573
NCIt 47 C97083
SNOMED-CT 64 36949004 6121001
UMLS 69 C0206067

Summaries for Focal Epithelial Hyperplasia

Disease Ontology : 12 A viral infectious disease that results_in infection located in mouth, has material basis in human papillomavirus (types 13 or 32), has symptom papules or nodules in the oral cavity.

MalaCards based summary : Focal Epithelial Hyperplasia, also known as multifocal epithelial hyperplasia, is related to apple allergy and immune deficiency, familial variable, and has symptoms including papules or nodules in the oral cavity and oral manifestations. An important gene associated with Focal Epithelial Hyperplasia is HLA-DRB1 (Major Histocompatibility Complex, Class II, DR Beta 1), and among its related pathways/superpathways are Actin Nucleation by ARP-WASP Complex and TCR Signaling (Qiagen). The drugs Liver Extracts and Chelating Agents have been mentioned in the context of this disorder. Affiliated tissues include tongue and mouth.

Wikipedia : 71 Heck\'s disease (also known as focal or multifocal epithelial hyperplasia) is an asymptomatic, benign... more...

Related Diseases for Focal Epithelial Hyperplasia

Diseases related to Focal Epithelial Hyperplasia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 49)
id Related Disease Score Top Affiliating Genes
1 apple allergy 10.1 HLA-DQB1 HLA-DRB1
2 immune deficiency, familial variable 10.1 HLA-DQB1 HLA-DRB1
3 lin-gettig syndrome 10.1 HLA-DQB1 HLA-DRB1
4 midline interhemispheric variant of holoprosencephaly 10.1 HLA-DQB1 HLA-DRB1
5 autosomal dominant intermediate charcot-marie-tooth 10.1 HLA-DQB1 HLA-DRB1
6 renal agenesis meningomyelocele mullerian defect 10.1 HLA-DQB1 HLA-DRB1
7 lyme disease - neurological complications 10.1 HLA-DQB1 HLA-DRB1
8 distal trisomy 14q 10.1 HLA-DQB1 HLA-DRB1
9 learning disability 10.1 HLA-DQB1 HLA-DRB1
10 linear lichen planus 10.1 HLA-DQB1 HLA-DRB1
11 night blindness 10.1 HLA-DQB1 HLA-DRB1
12 neonatal antiphospholipid syndrome 10.1 HLA-DQB1 HLA-DRB1
13 clostridium difficile colitis 10.1 HLA-DQB1 HLA-DRB1
14 myofibroma 10.1 HLA-DQB1 HLA-DRB1
15 cryptococcosis 10.1 HLA-DQB1 HLA-DRB1
16 anaerobic meningitis 10.1 HLA-DQB1 HLA-DRB1
17 low anorectal malformation 10.1 HLA-DQB1 HLA-DRB1
18 folinic acid-responsive seizures 10.1 HLA-DQB1 HLA-DRB1
19 albinism 10.1 HLA-DQA1 HLA-DRB1
20 lymphangiectasia, intestinal 10.1 HLA-DQB1 HLA-DRB1
21 kernicterus due to isoimmunization 10.1 HLA-DQA1 HLA-DRB1
22 choreatic disease 10.1 HLA-DQB1 HLA-DRB1
23 osteogenesis imperfecta congenita, microcephaly, and cataracts 10.1 HLA-DQA1 HLA-DQB1
24 parasitic helminthiasis infectious disease 10.1 HLA-DQB1 HLA-DRB1
25 anterior corneal pigmentation 10.1 HLA-DQB1 HLA-DRB1
26 peripheral artery disease 10.1 HLA-DQA1 HLA-DRB1
27 migraine with aura 10.0 HLA-DQA1 HLA-DQB1
28 b-cell lymphomas 10.0 HLA-DQB1 HLA-DRB1
29 barbiturate abuse 10.0 HLA-DQA1 HLA-DQB1
30 monocytic leukemia 10.0 HLA-DQB1 HLA-DRB1
31 erythematosquamous dermatosis 10.0 HLA-DQB1 HLA-DRB1
32 pulsating exophthalmos 9.9 HLA-DQA1 HLA-DRB1
33 bilateral parasagittal parieto-occipital polymicrogyria 9.9 HLA-DQA1 HLA-DQB1 HLA-DRB1
34 cervical adenoid basal carcinoma 9.9 HLA-DQA1 HLA-DQB1 HLA-DRB1
35 oromandibular dystonia 9.9 HLA-DQA1 HLA-DQB1 HLA-DRB1
36 bickerstaff brainstem encephalitis 9.9 HLA-DQA1 HLA-DQB1 HLA-DRB1
37 ragweed sensitivity 9.9 HLA-DQA1 HLA-DQB1 HLA-DRB1
38 mucositis 9.9
39 papilloma 9.9
40 intracranial hemorrhage in brain cerebrovascular malformations 9.9 HLA-DQA1 HLA-DRB1
41 parotid gland cancer 9.9 HLA-DQA1 HLA-DQB1 HLA-DRB1
42 diabetes mellitus, insulin-dependent, 20 9.8 HLA-DQA1 HLA-DQB1 HLA-DRB1
43 cousin syndrome 9.8 HLA-DQA1 HLA-DQB1 HLA-DRB1
44 rheumatoid arthritis 9.8 HLA-DQA1 HLA-DQB1 HLA-DRB1
45 leukocyte adhesion deficiency 9.7
46 keratoacanthoma 9.7
47 molluscum contagiosum 9.7
48 nemaline myopathy 2, autosomal recessive 9.6 HLA-DQA1 HLA-DQB1 HLA-DRB1
49 hemoglobin d disease 9.4 GP6 HLA-DQA1 HLA-DQB1 HLA-DRB1 MTFMT

Graphical network of the top 20 diseases related to Focal Epithelial Hyperplasia:



Diseases related to Focal Epithelial Hyperplasia

Symptoms & Phenotypes for Focal Epithelial Hyperplasia

Symptoms:

12
  • papules or nodules in the oral cavity

UMLS symptoms related to Focal Epithelial Hyperplasia:


oral manifestations

Drugs & Therapeutics for Focal Epithelial Hyperplasia

Drugs for Focal Epithelial Hyperplasia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1 Liver Extracts
2 Chelating Agents
3 Coagulants
4 Hemostatics
5 Pharmaceutical Solutions
6 Hypolipidemic Agents
7 Anti-Infective Agents
8 Anticholesteremic Agents
9 Lipid Regulating Agents
10 Antimetabolites
11
Chitosan Nutraceutical 9012-76-4 71853

Interventional clinical trials:


id Name Status NCT ID Phase
1 Risk Factors for Concurrent Endometrial Carcinoma in Patients With a Curettage Diagnosis of Endometrial Hyperplasia Unknown status NCT01273636
2 Quantitative Real-time Ultrasound Elastography for Characterisation of Liver Tumors Completed NCT02156700
3 Nonneoplastic Epithelial Disorders of Vulva and High Intensity Focused Ultrasound Recruiting NCT02890277

Search NIH Clinical Center for Focal Epithelial Hyperplasia

Cochrane evidence based reviews: focal epithelial hyperplasia

Genetic Tests for Focal Epithelial Hyperplasia

Anatomical Context for Focal Epithelial Hyperplasia

MalaCards organs/tissues related to Focal Epithelial Hyperplasia:

39
Tongue

The Foundational Model of Anatomy Ontology organs/tissues related to Focal Epithelial Hyperplasia:

18
Mouth

Publications for Focal Epithelial Hyperplasia

Articles related to Focal Epithelial Hyperplasia:

(show top 50) (show all 151)
id Title Authors Year
1
Pediatric Dermatology Photoquiz: Multiple Papules on the Mucosal Surfaces of a 17-Year-Old Boy. Focal epithelial hyperplasia (Heck's disease). ( 26758095 )
2016
2
Focal Epithelial Hyperplasia in Adult Patients With HIV Infection: Clearance With Topical Imiquimod. ( 27871359 )
2016
3
Focal Epithelial Hyperplasia (Heck's Disease) in a 57-Year-Old Brazilian Patient: A Case Report and Literature Review. ( 26985258 )
2016
4
Case Report of Focal Epithelial Hyperplasia (Heck's Disease) with Polymerase Chain Reaction Detection of Human Papillomavirus 13. ( 27072123 )
2016
5
Case Report of Focal Epithelial Hyperplasia (Heck's Disease) with Polymerase Chain Reaction Detection of Human Papillomavirus 13. ( 27882674 )
2016
6
Extensive Focal Epithelial Hyperplasia: A Case Report. ( 26351501 )
2015
7
Focal epithelial hyperplasia by human papillomavirus (HPV)-32 misdiagnosed as HPV-16 and treated with combination of retinoids, imiquimod and quadrivalent HPV vaccine. ( 26047065 )
2015
8
Molecular Biology for HPV Typing in Focal Epithelial Hyperplasia. ( 26456971 )
2015
9
Focal epithelial hyperplasia in a Turkish family. ( 25551850 )
2014
10
Focal epithelial hyperplasia arising after delivery of metal-ceramic fixed dental prosthesis. ( 25558348 )
2014
11
Oral Focal Epithelial Hyperplasia: Report of Three Cases. ( 24585348 )
2014
12
Focal epithelial hyperplasia associated with human papillomavirus 13 and common human leukocyte antigen alleles in a Turkish family. ( 24738569 )
2014
13
Focal epithelial hyperplasia (Heck's disease): a case report and review. ( 24706245 )
2014
14
Focal epithelial hyperplasia in a human immuno-deficiency virus patient treated with laser surgery. ( 25032206 )
2014
15
Human papillomavirus-32-associated focal epithelial hyperplasia accompanying HPV-16-positive papilloma-like lesions in oral mucosa. ( 23714908 )
2013
16
Focal epithelial hyperplasia (Heck's disease). ( 24353818 )
2013
17
Focal epithelial hyperplasia - an update. ( 23061874 )
2013
18
Focal epithelial hyperplasia. ( 24269109 )
2013
19
Focal epithelial hyperplasia (Heck's disease) in two Chinese females. ( 22154527 )
2012
20
Oral medicine case book 43--focal epithelial hyperplasia in an HIV-seropositive child. ( 23951749 )
2012
21
Dermacase. Can you identify this condition? Focal epithelial hyperplasia. ( 22170197 )
2011
22
A Case Report of Focal Epithelial Hyperplasia (Heck's disease) with PCR Detection of Human Papillomavirus. ( 23204755 )
2011
23
Focal epithelial hyperplasia: Case report. ( 22071419 )
2011
24
Oral focal epithelial hyperplasia: report of 3 cases with human papillomavirus DNA sequencing analysis. ( 22353414 )
2011
25
Extensive focal epithelial hyperplasia. ( 20039770 )
2010
26
Focal epithelial hyperplasia (Heck disease) related to highly active antiretroviral therapy in an HIV-seropositive child. A report of a case, and a review of the literature. ( 20632701 )
2010
27
Oral focal epithelial hyperplasia. ( 20863043 )
2010
28
Focal epithelial hyperplasia caused by human papillomavirus 13. ( 20508479 )
2010
29
Focal epithelial hyperplasia (Heck's Disease) in two siblings: response to treatment with imiquimod 5% cream. ( 20172842 )
2010
30
Focal epithelial hyperplasia: polymerase chain reaction amplification as a differential diagnosis tool. ( 19155739 )
2009
31
An uncommon focal epithelial hyperplasia manifestation. ( 19941767 )
2009
32
Detection of human papilloma virus DNA in seven cases of focal epithelial hyperplasia in Iran. ( 19453844 )
2009
33
Induction of focal epithelial hyperplasia in tongue of young bk6-E6/E7 HPV16 transgenic mice. ( 19165615 )
2009
34
Treatment of focal epithelial hyperplasia with topical imiquimod: report of three cases. ( 19689526 )
2009
35
Case of the month. Heck's disease (focal epithelial hyperplasia). ( 19405233 )
2009
36
Focal epithelial hyperplasia (Heck disease) in a black child. ( 17845152 )
2007
37
What is your diagnosis? Focal epithelial hyperplasia (Heck disease). ( 16706237 )
2006
38
General practitioner's pathology case 9. Focal epithelial hyperplasia. ( 17201309 )
2006
39
Molecular and serological evidence of the epidemiological association of HPV 13 with focal epithelial hyperplasia: a case-control study. ( 16793332 )
2006
40
Oral pathology quiz #51. Case number 4. Focal epithelial hyperplasia. ( 16800060 )
2006
41
Focal epithelial hyperplasia (Heck's disease): report of a case in a girl of Brazilian Indian descent. ( 16364096 )
2006
42
Oral focal epithelial hyperplasia: report of five cases. ( 16721472 )
2006
43
Extensive focal epithelial hyperplasia: case report. ( 16324231 )
2005
44
Oral pathology quiz #48. Case number 2. Focal epithelial hyperplasia. ( 16795955 )
2005
45
Clinical, histopathological and virological findings in patients with focal epithelial hyperplasia from Colombia. ( 15811076 )
2005
46
Focal epithelial hyperplasia. A rare disease in our area. ( 15735545 )
2005
47
Association of HLA-DR4 (DRB1*0404) with human papillomavirus infection in patients with focal epithelial hyperplasia. ( 15492185 )
2004
48
Oral pathology quiz # 42. Case 1. Focal epithelial hyperplasia. ( 15160430 )
2004
49
Focal epithelial hyperplasia (Heck's disease): report of two cases with PCR detection of human papillomavirus DNA. ( 15196147 )
2004
50
Focal epithelial hyperplasia: report of six cases from Ghana, West Africa. ( 12413174 )
2002

Variations for Focal Epithelial Hyperplasia

Expression for Focal Epithelial Hyperplasia

Search GEO for disease gene expression data for Focal Epithelial Hyperplasia.

Pathways for Focal Epithelial Hyperplasia

Pathways related to Focal Epithelial Hyperplasia according to GeneCards Suite gene sharing:

(show all 23)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.62 HLA-DQA1 HLA-DQB1 HLA-DRB1
2
Show member pathways
12.56 HLA-DQA1 HLA-DQB1 HLA-DRB1
3
Show member pathways
12.51 HLA-DQA1 HLA-DQB1 HLA-DRB1
4
Show member pathways
12.46 HLA-DQA1 HLA-DQB1 HLA-DRB1
5
Show member pathways
12.32 HLA-DQA1 HLA-DQB1 HLA-DRB1
6
Show member pathways
12.29 HLA-DQA1 HLA-DQB1 HLA-DRB1
7
Show member pathways
12.23 HLA-DQA1 HLA-DQB1 HLA-DRB1
8 12.14 HLA-DQA1 HLA-DQB1 HLA-DRB1
9
Show member pathways
12.1 HLA-DQA1 HLA-DQB1 HLA-DRB1
10
Show member pathways
12.06 HLA-DQA1 HLA-DQB1 HLA-DRB1
11 12.01 HLA-DQA1 HLA-DQB1 HLA-DRB1
12
Show member pathways
11.96 HLA-DQA1 HLA-DQB1 HLA-DRB1
13 11.91 HLA-DQA1 HLA-DQB1 HLA-DRB1
14
Show member pathways
11.87 HLA-DQA1 HLA-DQB1 HLA-DRB1
15 11.79 HLA-DQA1 HLA-DQB1 HLA-DRB1
16 11.74 HLA-DQA1 HLA-DQB1 HLA-DRB1
17
Show member pathways
11.63 HLA-DQA1 HLA-DQB1 HLA-DRB1
18
Show member pathways
11.58 HLA-DQA1 HLA-DQB1 HLA-DRB1
19 11.51 HLA-DQA1 HLA-DQB1 HLA-DRB1
20 11.42 HLA-DQA1 HLA-DQB1 HLA-DRB1
21 11.29 HLA-DQA1 HLA-DQB1 HLA-DRB1
22 10.98 HLA-DQA1 HLA-DQB1 HLA-DRB1
23 10.55 HLA-DQA1 HLA-DQB1 HLA-DRB1

GO Terms for Focal Epithelial Hyperplasia

Cellular components related to Focal Epithelial Hyperplasia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 Golgi membrane GO:0000139 9.65 HLA-DQA1 HLA-DQB1 HLA-DRB1
2 lysosomal membrane GO:0005765 9.63 HLA-DQA1 HLA-DQB1 HLA-DRB1
3 endosome membrane GO:0010008 9.61 HLA-DQA1 HLA-DQB1 HLA-DRB1
4 trans-Golgi network membrane GO:0032588 9.58 HLA-DQA1 HLA-DQB1 HLA-DRB1
5 endocytic vesicle membrane GO:0030666 9.54 HLA-DQA1 HLA-DQB1 HLA-DRB1
6 ER to Golgi transport vesicle membrane GO:0012507 9.5 HLA-DQA1 HLA-DQB1 HLA-DRB1
7 transport vesicle membrane GO:0030658 9.43 HLA-DQA1 HLA-DQB1 HLA-DRB1
8 clathrin-coated endocytic vesicle membrane GO:0030669 9.33 HLA-DQA1 HLA-DQB1 HLA-DRB1
9 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 9.13 HLA-DQA1 HLA-DQB1 HLA-DRB1
10 MHC class II protein complex GO:0042613 8.8 HLA-DQA1 HLA-DQB1 HLA-DRB1

Biological processes related to Focal Epithelial Hyperplasia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.63 HLA-DQA1 HLA-DQB1 HLA-DRB1
2 T cell receptor signaling pathway GO:0050852 9.61 HLA-DQA1 HLA-DQB1 HLA-DRB1
3 antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0019886 9.58 HLA-DQA1 HLA-DQB1 HLA-DRB1
4 T cell costimulation GO:0031295 9.5 HLA-DQA1 HLA-DQB1 HLA-DRB1
5 interferon-gamma-mediated signaling pathway GO:0060333 9.43 HLA-DQA1 HLA-DQB1 HLA-DRB1
6 humoral immune response mediated by circulating immunoglobulin GO:0002455 9.37 HLA-DQB1 HLA-DRB1
7 immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 9.16 HLA-DQB1 HLA-DRB1
8 antigen processing and presentation GO:0019882 9.13 HLA-DQA1 HLA-DQB1 HLA-DRB1
9 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 8.8 HLA-DQA1 HLA-DQB1 HLA-DRB1

Molecular functions related to Focal Epithelial Hyperplasia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 peptide antigen binding GO:0042605 9.13 HLA-DQA1 HLA-DQB1 HLA-DRB1
2 MHC class II receptor activity GO:0032395 8.8 HLA-DQA1 HLA-DQB1 HLA-DRB1

Sources for Focal Epithelial Hyperplasia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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