MCID: FCL010
MIFTS: 38

Focal Epithelial Hyperplasia malady

Category: Infectious diseases

Aliases & Classifications for Focal Epithelial Hyperplasia

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Aliases & Descriptions for Focal Epithelial Hyperplasia:

Name: Focal Epithelial Hyperplasia 11 50 39 13 68
Multifocal Epithelial Hyperplasia 11
 
Heck's Disease 11
Heck Disease 11

Classifications:



External Ids:

Disease Ontology11 DOID:5362
MeSH39 D017573
SNOMED-CT62 36949004, 6121001
NCIt45 C97083

Summaries for Focal Epithelial Hyperplasia

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Disease Ontology:11 A viral infectious disease that results in infection located in mouth, has material basis in human papillomavirus (types 13 or 32), has symptom papules or nodules in the oral cavity.

MalaCards based summary: Focal Epithelial Hyperplasia, also known as multifocal epithelial hyperplasia, is related to apple allergy and immune deficiency, familial variable, and has symptoms including oral manifestations and papules or nodules in the oral cavity. An important gene associated with Focal Epithelial Hyperplasia is HLA-DRB1 (Major Histocompatibility Complex, Class II, DR Beta 1), and among its related pathways are Interferon gamma signaling and HTLV-I infection. Affiliated tissues include mouth and tongue.

Wikipedia:71 Heck\'s disease (also known as focal or multifocal epithelial hyperplasia) is an asymptomatic, benign... more...

Related Diseases for Focal Epithelial Hyperplasia

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Diseases related to Focal Epithelial Hyperplasia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 49)
idRelated DiseaseScoreTop Affiliating Genes
1apple allergy10.1HLA-DQB1, HLA-DRB1
2immune deficiency, familial variable10.1HLA-DQB1, HLA-DRB1
3lin-gettig syndrome10.1HLA-DQB1, HLA-DRB1
4midline interhemispheric variant of holoprosencephaly10.1HLA-DQB1, HLA-DRB1
5autosomal dominant intermediate charcot-marie-tooth10.1HLA-DQB1, HLA-DRB1
6renal agenesis meningomyelocele mullerian defect10.1HLA-DQB1, HLA-DRB1
7lyme disease - neurological complications10.1HLA-DQB1, HLA-DRB1
8distal trisomy 14q10.1HLA-DQB1, HLA-DRB1
9learning disability10.1HLA-DQB1, HLA-DRB1
10linear lichen planus10.1HLA-DQB1, HLA-DRB1
11night blindness10.1HLA-DQB1, HLA-DRB1
12neonatal antiphospholipid syndrome10.1HLA-DQB1, HLA-DRB1
13clostridium difficile colitis10.1HLA-DQB1, HLA-DRB1
14myofibroma10.1HLA-DQB1, HLA-DRB1
15cryptococcosis10.1HLA-DQB1, HLA-DRB1
16anaerobic meningitis10.1HLA-DQB1, HLA-DRB1
17low anorectal malformation10.1HLA-DQB1, HLA-DRB1
18folinic acid-responsive seizures10.1HLA-DQB1, HLA-DRB1
19albinism10.1HLA-DQA1, HLA-DRB1
20lymphangiectasia, intestinal10.1HLA-DQB1, HLA-DRB1
21kernicterus due to isoimmunization10.1HLA-DQA1, HLA-DRB1
22choreatic disease10.1HLA-DQB1, HLA-DRB1
23osteogenesis imperfecta congenita, microcephaly, and cataracts10.1HLA-DQA1, HLA-DQB1
24parasitic helminthiasis infectious disease10.1HLA-DQB1, HLA-DRB1
25anterior corneal pigmentation10.1HLA-DQB1, HLA-DRB1
26peripheral artery disease10.1HLA-DQA1, HLA-DRB1
27migraine with aura10.0HLA-DQA1, HLA-DQB1
28b-cell lymphomas10.0HLA-DQB1, HLA-DRB1
29barbiturate abuse10.0HLA-DQA1, HLA-DQB1
30monocytic leukemia10.0HLA-DQB1, HLA-DRB1
31erythematosquamous dermatosis10.0HLA-DQB1, HLA-DRB1
32pulsating exophthalmos9.9HLA-DQA1, HLA-DRB1
33bilateral parasagittal parieto-occipital polymicrogyria9.9HLA-DQA1, HLA-DQB1, HLA-DRB1
34cervical adenoid basal carcinoma9.9HLA-DQA1, HLA-DQB1, HLA-DRB1
35oromandibular dystonia9.9HLA-DQA1, HLA-DQB1, HLA-DRB1
36bickerstaff brainstem encephalitis9.9HLA-DQA1, HLA-DQB1, HLA-DRB1
37ragweed sensitivity9.9HLA-DQA1, HLA-DQB1, HLA-DRB1
38mucositis9.9
39papilloma9.9
40intracranial hemorrhage in brain cerebrovascular malformations9.9HLA-DQA1, HLA-DRB1
41parotid gland cancer9.9HLA-DQA1, HLA-DQB1, HLA-DRB1
42diabetes mellitus, insulin-dependent, 209.8HLA-DQA1, HLA-DQB1, HLA-DRB1
43cousin syndrome9.8HLA-DQA1, HLA-DQB1, HLA-DRB1
44rheumatoid arthritis9.8HLA-DQA1, HLA-DQB1, HLA-DRB1
45leukocyte adhesion deficiency9.7
46keratoacanthoma9.7
47molluscum contagiosum9.7
48nemaline myopathy 2, autosomal recessive9.6HLA-DQA1, HLA-DQB1, HLA-DRB1
49hemoglobin d disease9.4GP6, HLA-DQA1, HLA-DQB1, HLA-DRB1, MTFMT

Graphical network of the top 20 diseases related to Focal Epithelial Hyperplasia:



Diseases related to focal epithelial hyperplasia

Symptoms & Phenotypes for Focal Epithelial Hyperplasia

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Symptoms:

 11
  • papules or nodules in the oral cavity

UMLS symptoms related to Focal Epithelial Hyperplasia:


oral manifestations

Drugs & Therapeutics for Focal Epithelial Hyperplasia

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Drugs for Focal Epithelial Hyperplasia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1Liver Extracts4067
2Coagulants1500
3Hemostatics1443
4Hypolipidemic Agents2785
5Lipid Regulating Agents2766
6Chelating Agents1423
7Anticholesteremic Agents2025
8Anti-Infective Agents22062
9Antimetabolites12054
10Pharmaceutical Solutions8192
11
ChitosanNutraceutical479012-76-471853
Synonyms:
CTA 4
Chicol
Chitopearl 3510
Chitopearl BC 3000
Chitopearl BCW 2500
Chitopearl BCW 3000
Chitopearl BCW 3500
Chitopearl BCW 3505
Chitopearl BCW 3507
Deacetylchitin
Flonac C
Flonac N
 
Kimitsu Chitosan F
Kimitsu Chitosan F 2
Kimitsu Chitosan H
Kimitsu Chitosan L
Kimitsu Chitosan M
Kytex H
Kytex M
Poliglusam
Sea Cure F
Sea Cure Plus
YEA
beta-1,4-Poly-D-glucosamine
beta-1,4-Poly-delta-glucosamine

Interventional clinical trials:

idNameStatusNCT IDPhase
1Risk Factors for Concurrent Endometrial Carcinoma in Patients With a Curettage Diagnosis of Endometrial HyperplasiaUnknown statusNCT01273636
2Quantitative Real-time Ultrasound Elastography for Characterisation of Liver TumorsCompletedNCT02156700
3Nonneoplastic Epithelial Disorders of Vulva and High Intensity Focused UltrasoundRecruitingNCT02890277

Search NIH Clinical Center for Focal Epithelial Hyperplasia


Cochrane evidence based reviews: focal epithelial hyperplasia

Genetic Tests for Focal Epithelial Hyperplasia

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Anatomical Context for Focal Epithelial Hyperplasia

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MalaCards organs/tissues related to Focal Epithelial Hyperplasia:

36
Tongue

FMA organs/tissues related to Focal Epithelial Hyperplasia:

17
Mouth

Publications for Focal Epithelial Hyperplasia

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Articles related to Focal Epithelial Hyperplasia:

(show top 50)    (show all 151)
idTitleAuthorsYear
1
Pediatric Dermatology Photoquiz: Multiple Papules on the Mucosal Surfaces of a 17-Year-Old Boy. Focal epithelial hyperplasia (Heck's disease). (26758095)
2016
2
Focal Epithelial Hyperplasia in Adult Patients With HIV Infection: Clearance With Topical Imiquimod. (27871359)
2016
3
Focal Epithelial Hyperplasia (Heck's Disease) in a 57-Year-Old Brazilian Patient: A Case Report and Literature Review. (26985258)
2016
4
Case Report of Focal Epithelial Hyperplasia (Heck's Disease) with Polymerase Chain Reaction Detection of Human Papillomavirus 13. (27072123)
2016
5
Case Report of Focal Epithelial Hyperplasia (Heck's Disease) with Polymerase Chain Reaction Detection of Human Papillomavirus 13. (27882674)
2016
6
Extensive Focal Epithelial Hyperplasia: A Case Report. (26351501)
2015
7
Focal epithelial hyperplasia by human papillomavirus (HPV)-32 misdiagnosed as HPV-16 and treated with combination of retinoids, imiquimod and quadrivalent HPV vaccine. (26047065)
2015
8
Molecular Biology for HPV Typing in Focal Epithelial Hyperplasia. (26456971)
2015
9
Focal epithelial hyperplasia in a Turkish family. (25551850)
2014
10
Focal epithelial hyperplasia arising after delivery of metal-ceramic fixed dental prosthesis. (25558348)
2014
11
Oral Focal Epithelial Hyperplasia: Report of Three Cases. (24585348)
2014
12
Focal epithelial hyperplasia associated with human papillomavirus 13 and common human leukocyte antigen alleles in a Turkish family. (24738569)
2014
13
Focal epithelial hyperplasia (Heck's disease): a case report and review. (24706245)
2014
14
Focal epithelial hyperplasia in a human immuno-deficiency virus patient treated with laser surgery. (25032206)
2014
15
Human papillomavirus-32-associated focal epithelial hyperplasia accompanying HPV-16-positive papilloma-like lesions in oral mucosa. (23714908)
2013
16
Focal epithelial hyperplasia (Heck's disease). (24353818)
2013
17
Focal epithelial hyperplasia - an update. (23061874)
2013
18
Focal epithelial hyperplasia. (24269109)
2013
19
Focal epithelial hyperplasia (Heck's disease) in two Chinese females. (22154527)
2012
20
Oral medicine case book 43--focal epithelial hyperplasia in an HIV-seropositive child. (23951749)
2012
21
Dermacase. Can you identify this condition? Focal epithelial hyperplasia. (22170197)
2011
22
A Case Report of Focal Epithelial Hyperplasia (Heck's disease) with PCR Detection of Human Papillomavirus. (23204755)
2011
23
Focal epithelial hyperplasia: Case report. (22071419)
2011
24
Oral focal epithelial hyperplasia: report of 3 cases with human papillomavirus DNA sequencing analysis. (22353414)
2011
25
Extensive focal epithelial hyperplasia. (20039770)
2010
26
Focal epithelial hyperplasia (Heck disease) related to highly active antiretroviral therapy in an HIV-seropositive child. A report of a case, and a review of the literature. (20632701)
2010
27
Oral focal epithelial hyperplasia. (20863043)
2010
28
Focal epithelial hyperplasia caused by human papillomavirus 13. (20508479)
2010
29
Focal epithelial hyperplasia (Heck's Disease) in two siblings: response to treatment with imiquimod 5% cream. (20172842)
2010
30
Focal epithelial hyperplasia: polymerase chain reaction amplification as a differential diagnosis tool. (19155739)
2009
31
An uncommon focal epithelial hyperplasia manifestation. (19941767)
2009
32
Detection of human papilloma virus DNA in seven cases of focal epithelial hyperplasia in Iran. (19453844)
2009
33
Induction of focal epithelial hyperplasia in tongue of young bk6-E6/E7 HPV16 transgenic mice. (19165615)
2009
34
Treatment of focal epithelial hyperplasia with topical imiquimod: report of three cases. (19689526)
2009
35
Case of the month. Heck's disease (focal epithelial hyperplasia). (19405233)
2009
36
Focal epithelial hyperplasia (Heck disease) in a black child. (17845152)
2007
37
What is your diagnosis? Focal epithelial hyperplasia (Heck disease). (16706237)
2006
38
General practitioner's pathology case 9. Focal epithelial hyperplasia. (17201309)
2006
39
Molecular and serological evidence of the epidemiological association of HPV 13 with focal epithelial hyperplasia: a case-control study. (16793332)
2006
40
Oral pathology quiz #51. Case number 4. Focal epithelial hyperplasia. (16800060)
2006
41
Focal epithelial hyperplasia (Heck's disease): report of a case in a girl of Brazilian Indian descent. (16364096)
2006
42
Oral focal epithelial hyperplasia: report of five cases. (16721472)
2006
43
Extensive focal epithelial hyperplasia: case report. (16324231)
2005
44
Oral pathology quiz #48. Case number 2. Focal epithelial hyperplasia. (16795955)
2005
45
Clinical, histopathological and virological findings in patients with focal epithelial hyperplasia from Colombia. (15811076)
2005
46
Focal epithelial hyperplasia. A rare disease in our area. (15735545)
2005
47
Association of HLA-DR4 (DRB1*0404) with human papillomavirus infection in patients with focal epithelial hyperplasia. (15492185)
2004
48
Oral pathology quiz # 42. Case 1. Focal epithelial hyperplasia. (15160430)
2004
49
Focal epithelial hyperplasia (Heck's disease): report of two cases with PCR detection of human papillomavirus DNA. (15196147)
2004
50
Focal epithelial hyperplasia: report of six cases from Ghana, West Africa. (12413174)
2002

Variations for Focal Epithelial Hyperplasia

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Expression for genes affiliated with Focal Epithelial Hyperplasia

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Search GEO for disease gene expression data for Focal Epithelial Hyperplasia.

Pathways for genes affiliated with Focal Epithelial Hyperplasia

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Pathways related to Focal Epithelial Hyperplasia according to GeneCards Suite gene sharing:

(show all 23)
idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
8.9HLA-DQA1, HLA-DQB1, HLA-DRB1
28.9HLA-DQA1, HLA-DQB1, HLA-DRB1
3
Show member pathways
8.9HLA-DQA1, HLA-DQB1, HLA-DRB1
4
Show member pathways
8.9HLA-DQA1, HLA-DQB1, HLA-DRB1
5
Show member pathways
8.9HLA-DQA1, HLA-DQB1, HLA-DRB1
6
Show member pathways
8.9HLA-DQA1, HLA-DQB1, HLA-DRB1
7
Show member pathways
8.9HLA-DQA1, HLA-DQB1, HLA-DRB1
8
Show member pathways
8.9HLA-DQA1, HLA-DQB1, HLA-DRB1
9
Show member pathways
8.9HLA-DQA1, HLA-DQB1, HLA-DRB1
10
Show member pathways
8.9HLA-DQA1, HLA-DQB1, HLA-DRB1
118.9HLA-DQA1, HLA-DQB1, HLA-DRB1
12
Show member pathways
8.9HLA-DQA1, HLA-DQB1, HLA-DRB1
138.9HLA-DQA1, HLA-DQB1, HLA-DRB1
148.9HLA-DQA1, HLA-DQB1, HLA-DRB1
158.9HLA-DQA1, HLA-DQB1, HLA-DRB1
168.9HLA-DQA1, HLA-DQB1, HLA-DRB1
17
Show member pathways
8.9HLA-DQA1, HLA-DQB1, HLA-DRB1
188.9HLA-DQA1, HLA-DQB1, HLA-DRB1
19
Show member pathways
8.9HLA-DQA1, HLA-DQB1, HLA-DRB1
208.9HLA-DQA1, HLA-DQB1, HLA-DRB1
21
Show member pathways
8.9HLA-DQA1, HLA-DQB1, HLA-DRB1
228.9HLA-DQA1, HLA-DQB1, HLA-DRB1
238.9HLA-DQA1, HLA-DQB1, HLA-DRB1

GO Terms for genes affiliated with Focal Epithelial Hyperplasia

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Cellular components related to Focal Epithelial Hyperplasia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1clathrin-coated endocytic vesicle membraneGO:00306699.6HLA-DQA1, HLA-DQB1, HLA-DRB1
2endocytic vesicle membraneGO:00306669.6HLA-DQA1, HLA-DQB1, HLA-DRB1
3endosome membraneGO:00100089.6HLA-DQA1, HLA-DQB1, HLA-DRB1
4ER to Golgi transport vesicle membraneGO:00125079.6HLA-DQA1, HLA-DQB1, HLA-DRB1
5Golgi membraneGO:00001399.5HLA-DQA1, HLA-DQB1, HLA-DRB1
6integral component of lumenal side of endoplasmic reticulum membraneGO:00715569.5HLA-DQA1, HLA-DQB1, HLA-DRB1
7lysosomal membraneGO:00057659.4HLA-DQA1, HLA-DQB1, HLA-DRB1
8MHC class II protein complexGO:00426139.4HLA-DQA1, HLA-DQB1, HLA-DRB1
9trans-Golgi network membraneGO:00325889.3HLA-DQA1, HLA-DQB1, HLA-DRB1
10transport vesicle membraneGO:00306588.9HLA-DQA1, HLA-DQB1, HLA-DRB1

Biological processes related to Focal Epithelial Hyperplasia according to GeneCards Suite gene sharing:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1humoral immune response mediated by circulating immunoglobulinGO:000245510.2HLA-DQB1, HLA-DRB1
2immunoglobulin production involved in immunoglobulin mediated immune responseGO:000238110.1HLA-DQB1, HLA-DRB1
3antigen processing and presentationGO:00198829.6HLA-DQA1, HLA-DQB1, HLA-DRB1
4antigen processing and presentation of exogenous peptide antigen via MHC class IIGO:00198869.6HLA-DQA1, HLA-DQB1, HLA-DRB1
5antigen processing and presentation of peptide or polysaccharide antigen via MHC class IIGO:00025049.6HLA-DQA1, HLA-DQB1, HLA-DRB1
6immune responseGO:00069559.5HLA-DQA1, HLA-DQB1, HLA-DRB1
7interferon-gamma-mediated signaling pathwayGO:00603339.5HLA-DQA1, HLA-DQB1, HLA-DRB1
8T cell costimulationGO:00312959.4HLA-DQA1, HLA-DQB1, HLA-DRB1
9T cell receptor signaling pathwayGO:00508528.9HLA-DQA1, HLA-DQB1, HLA-DRB1

Molecular functions related to Focal Epithelial Hyperplasia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1MHC class II receptor activityGO:00323959.3HLA-DQA1, HLA-DQB1, HLA-DRB1
2peptide antigen bindingGO:00426058.9HLA-DQA1, HLA-DQB1, HLA-DRB1

Sources for Focal Epithelial Hyperplasia

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet