MCID: FCL010
MIFTS: 32

Focal Epithelial Hyperplasia malady

Summaries for Focal Epithelial Hyperplasia

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8Disease Ontology, 63Wikipedia, 46OMIM, 32MalaCards
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Disease Ontology:8 A viral infectious disease that results in infection located in mouth, has material basis in human papillomavirus (types 13 or 32), has symptom papules or nodules in the oral cavity.

MalaCards: Focal Epithelial Hyperplasia, also known as multifocal epithelial hyperplasia, is related to sarcoidosis and papilloma, and has symptoms including papules or nodules in the oral cavity An important gene associated with Focal Epithelial Hyperplasia is IFNA2 (interferon, alpha 2), and among its related pathways are Interferon Signaling and Tuberculosis. The compounds tamoxifen and histidine have been mentioned in the context of this disorder. Affiliated tissues include mouth and tongue.

Wikipedia:63 Heck\'s disease (also known as focal epithelial hyperplasia) is a condition characterized by white to... more...

Description from OMIM:46 229045

Aliases & Classifications for Focal Epithelial Hyperplasia

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Sources:
8Disease Ontology, 44Novoseek, 60UMLS, 34MeSH, 46OMIM, 56SNOMED-CT
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Aliases & Descriptions:

focal epithelial hyperplasia 8 44 60
multifocal epithelial hyperplasia 8
heck's disease 8
heck disease 8


External Ids:

Disease Ontology8 DOID:5362
MeSH34 D017573
SNOMED-CT56 6121001, 36949004
OMIM46 229045

Related Diseases for Focal Epithelial Hyperplasia

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Focal Epithelial Hyperplasia:



Diseases related to focal epithelial hyperplasia

Clinical Features for Focal Epithelial Hyperplasia

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46OMIM, 8Disease Ontology
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Clinical features from OMIM:

229045

Symptoms:

8
  • papules or nodules in the oral cavity

Drugs & Therapeutics for Focal Epithelial Hyperplasia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search CenterWatch for Focal Epithelial Hyperplasia

Genetic Tests for Focal Epithelial Hyperplasia

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Anatomical Context for Focal Epithelial Hyperplasia

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32MalaCards, 14FMA
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MalaCards organs/tissues related to Focal Epithelial Hyperplasia:

32
Tongue

FMA organs/tissues related to Focal Epithelial Hyperplasia:

14
Mouth

Animal Models for Focal Epithelial Hyperplasia or affiliated genes

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Publications for Focal Epithelial Hyperplasia

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50PubMed
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Articles related to Focal Epithelial Hyperplasia:

(show top 50)    (show all 138)
idTitleAuthorsYear
1
Oral medicine case book 43--focal epithelial hyperplasia in an HIV-seropositive child. (23951749)
2012
2
Focal epithelial hyperplasia: Case report. (22071419)
2011
3
Oral focal epithelial hyperplasia: report of 3 cases with human papillomavirus DNA sequencing analysis. (22353414)
2011
4
Focal epithelial hyperplasia (Heck disease) related to highly active antiretroviral therapy in an HIV-seropositive child. A report of a case, and a review of the literature. (20632701)
2010
5
Extensive focal epithelial hyperplasia. (20039770)
2010
6
Focal epithelial hyperplasia caused by human papillomavirus 13. (20508479)
2010
7
Focal epithelial hyperplasia: polymerase chain reaction amplification as a differential diagnosis tool. (19155739)
2009
8
Induction of focal epithelial hyperplasia in tongue of young bk6-E6/E7 HPV16 transgenic mice. (19165615)
2009
9
Treatment of focal epithelial hyperplasia with topical imiquimod: report of three cases. (19689526)
2009
10
Detection of human papilloma virus DNA in seven cases of focal epithelial hyperplasia in Iran. (19453844)
2009
11
Osteopontin as an injury marker expressing in epithelial hyperplasia lesions helpful in prognosis of focal segmental glomerulosclerosis. (17900509)
2007
12
Focal epithelial hyperplasia (Heck disease) in a black child. (17845152)
2007
13
Molecular and serological evidence of the epidemiological association of HPV 13 with focal epithelial hyperplasia: a case-control study. (16793332)
2006
14
Oral focal epithelial hyperplasia: report of five cases. (16721472)
2006
15
Focal epithelial hyperplasia (Heck's disease). (11526896)
2001
16
Focal epithelial hyperplasia: a multifocal oral human papillomavirus infection. (10769863)
2000
17
Oral focal epithelial hyperplasia in a howler monkey (Alouatta fusca). (11055880)
2000
18
Oral focal epithelial hyperplasia. (10882951)
2000
19
Focal epithelial hyperplasia in an Ecuadorian girl. (10626102)
1999
20
Focal epithelial hyperplasia (Heck disease) associated with AIDS. (8944355)
1996
21
Focal epithelial hyperplasia. (7534895)
1994
22
Focal epithelial hyperplasia (Heck's disease) with generalized lesions of the gingiva. A case report. (8426292)
1993
23
Focal epithelial hyperplasia: Heck disease. (8415301)
1993
24
Focal epithelial hyperplasia (Heck's disease): the first reported case from Italy. (1850180)
1991
25
Multiple oral papules in a native South American girl. Focal epithelial hyperplasia (Heck's disease). (2036039)
1991
26
A papillomavirus related to HPV type 13 in oral focal epithelial hyperplasia in the pygmy chimpanzee. (1654423)
1991
27
Host response to papilloma virus in focal epithelial hyperplasia. (2551213)
1989
28
Focal epithelial hyperplasia: a survey of two isolated communities in the Cape Province of South Africa. (3474101)
1987
29
Human papillomavirus type 13 and focal epithelial hyperplasia of the oral mucosa: DNA hybridization on paraffin-embedded specimens. (3037771)
1987
30
Focal epithelial hyperplasia: first report in MAcxico. Clinical, light and ultrastructural microscopic studies. (3592890)
1986
31
A human papillomavirus closely related to HPV 13 found in a focal epithelial hyperplasia lesion (Heck disease). (6089671)
1984
32
Characterization of human papillomavirus type 13 from focal epithelial hyperplasia Heck lesions. (6312071)
1983
33
Focal epithelial hyperplasia. Report of three cases from Nigeria, West Africa. (6578481)
1983
34
HPV 1 DNA in lesions of focal epithelial hyperplasia Heck. (6260042)
1980
35
Heck's disease (focal epithelial hyperplasia). (528698)
1979
36
Focal epithelial hyperplasia in Abu Dhabi. (277855)
1978
37
Focal epithelial hyperplasia in Israeli families of Libyan origin. (277883)
1978
38
Focal epithelial hyperplasia in a group of South Africans: Its ultrastructural features. (402449)
1977
39
Focal epithelial hyperplasia in a group of south africans: Its clinical and microscopic features. (402448)
1977
40
Focal epithelial hyperplasia (Heck's disease): report of case. (1064652)
1976
41
Geographical aspects of oral focal epithelial hyperplasia. (4718559)
1973
42
Focal epithelial hyperplasia in an Israeli family. (4517103)
1973
43
Rare oral viral disorders (molluscum contagiosum, localized keratoacanthoma, verrucae, condyloma acuminatum, and focal epithelial hyperplasia). (4562543)
1972
44
Focal epithelial hyperplasia. (4510327)
1972
45
Focal epithelial hyperplasia mimicking tumor at gastroenterostomy site. (5035182)
1972
46
Focal epithelial hyperplasia. Report of a case in a South African Caucasoid. (5282068)
1971
47
Focal epithelial hyperplasia. Report of seven cases from Iraq. (5277369)
1971
48
Histopathology of focal epithelial hyperplasia. Evidence of viral infection. (4906790)
1969
49
Focal epithelial hyperplasia (Heck's disease) in an adult Caucasian. (5241348)
1968
50
FOCAL EPITHELIAL HYPERPLASIA: AN UNUSUAL ORAL MUCOSAL LESION FOUND IN INDIAN CHILDREN. (14322615)
1965

Genetic Variations for Focal Epithelial Hyperplasia

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Expression for genes affiliated with Focal Epithelial Hyperplasia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Focal Epithelial Hyperplasia

Search GEO for disease gene expression data for Focal Epithelial Hyperplasia.

Pathways for genes affiliated with Focal Epithelial Hyperplasia

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53Reactome, 29KEGG, 51QIAGEN
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Compounds for genes affiliated with Focal Epithelial Hyperplasia

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44Novoseek, 49PharmGKB, 28IUPHAR, 11DrugBank
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Compounds related to Focal Epithelial Hyperplasia according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1tamoxifen44 49 28 1112.0EPHX1, IFNA2
2histidine448.7EPHX1, IFNA2
3tyrosine448.4EPHX1, HLA-DRB1, IFNA2

GO Terms for genes affiliated with Focal Epithelial Hyperplasia

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16Gene Ontology
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Biological processes related to Focal Epithelial Hyperplasia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine-mediated signaling pathwayGO:0192219.3HLA-DRB1, IFNA2

Products for genes affiliated with Focal Epithelial Hyperplasia

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Sources for Focal Epithelial Hyperplasia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet