Aliases & Classifications for Focal Hand Dystonia

MalaCards integrated aliases for Focal Hand Dystonia:

Name: Focal Hand Dystonia 12 14
Organic Writer's Cramp 12 69
Dystonia, Focal, Task-Specific 69

Classifications:



External Ids:

Disease Ontology 12 DOID:0050841
ICD9CM 35 333.84
MeSH 42 D020821
UMLS 69 C0154676

Summaries for Focal Hand Dystonia

Disease Ontology : 12 A focal dystonia that affects a single muscle or small group of muscles in the hand resulting from involuntary muscular contractions.

MalaCards based summary : Focal Hand Dystonia, also known as organic writer's cramp, is related to cervical dystonia and focal dystonia, and has symptoms including ataxia and spasmodic torticollis. An important gene associated with Focal Hand Dystonia is TOR1A (Torsin Family 1 Member A). The drugs Acetylcholine and Cholinergic Agents have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and testes, and related phenotypes are renal/urinary system and vision/eye

Related Diseases for Focal Hand Dystonia

Graphical network of the top 20 diseases related to Focal Hand Dystonia:



Diseases related to Focal Hand Dystonia

Symptoms & Phenotypes for Focal Hand Dystonia

UMLS symptoms related to Focal Hand Dystonia:


ataxia, spasmodic torticollis

MGI Mouse Phenotypes related to Focal Hand Dystonia:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 renal/urinary system MP:0005367 9.35 CTBS DRD5 PANK2 PDE8B PDGFB
2 vision/eye MP:0005391 9.1 CAMP DRD5 PANK2 PDGFB TOR1A VIM

Drugs & Therapeutics for Focal Hand Dystonia

Drugs for Focal Hand Dystonia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcholine Approved Phase 3,Phase 1,Phase 2 51-84-3 187
2 Cholinergic Agents Phase 3,Phase 1,Phase 2
3 Neurotransmitter Agents Phase 3,Phase 1,Phase 2
4 Botulinum Toxins Phase 3,Phase 1,Phase 2
5 abobotulinumtoxinA Phase 3
6 Neuromuscular Agents Phase 3,Phase 2
7 onabotulinumtoxinA Phase 3
8 Peripheral Nervous System Agents Phase 3,Phase 2
9 Botulinum Toxins, Type A Phase 3
10 incobotulinumtoxinA Phase 2
11
Flumazenil Approved 78755-81-4 3373

Interventional clinical trials:

(show all 28)

id Name Status NCT ID Phase Drugs
1 Comparison of Electrophysiologic and Ultrasound Guidance for Onabotulinum Toxin A Injections in Focal Upper Extremity Dystonia and Spasticity Recruiting NCT02326818 Phase 3
2 Transcranial Electrical Polarization to Treat Focal Hand Dystonia Completed NCT00106782 Phase 2
3 rTMS and Retraining in Focal Hand Dystonia Completed NCT01738581 Phase 1, Phase 2
4 Motor Training to Treat Hand Dystonia Completed NCT00021853 Phase 2
5 Pilot Trial of Botulinum Toxin and Occupational Therapy for Writer's Cramp Completed NCT02015039 Phase 1, Phase 2 BoNT Injections
6 Incobotulinum Toxin A (Xeomin®) As A Treatment For Focal Task-Specific Dystonia Of The Musician's Hand Recruiting NCT02107261 Phase 2 incobotulinumtoxin A
7 Deep Brain Stimulation Surgery for Focal Hand Dystonia Not yet recruiting NCT02911103 Phase 1, Phase 2
8 Repetitive Transcranial Magnetic Stimulation for the Treatment of Focal Hand Dystonia Completed NCT01884064 Phase 1
9 Somatosensory Processing in Focal Hand Dystonia Unknown status NCT00579033
10 Long-Term Motor Learning in Focal Hand Dystonia Completed NCT00325091
11 Muscle Contraction in Patients With Focal Hand Dystonia Completed NCT00376753
12 Neurophysiology of Task-Specificity of Focal Hand Dystonia Completed NCT00309010
13 Brain Changes in Patients With Focal Hand Dystonia Completed NCT00306865
14 fMRI Studies of Task Specificity in Focal Hand Dystonia Completed NCT00310414
15 Movement-Related Brain Networks Involved in Hand Dystonia Completed NCT00137384
16 EEG and EMG Studies of Hand Dystonia Completed NCT00025701
17 Transcranial Magnetic Stimulation and Electrical Stimulation of Nerves to Study Focal Dystonia Completed NCT00050024
18 Sensory Training to Treat Focal Dystonia Completed NCT00006336
19 Validating a New Writer s Cramp Scale Completed NCT01579266
20 Association Between Focal Dystonia and Complex Regional Pain Syndrome Completed NCT00595439
21 Effect of Increasing Motor Cortex Inhibition on Task Specific Dystonia Recruiting NCT01823237
22 Transcranial Magnetic Stimulation for Focal Hand Dystonia Recruiting NCT01792336
23 Pathophysiology of Dystonia and Complex Regional Pain Syndrome Recruiting NCT03223623
24 Compare Two Guidance Techniques for Botulinum Toxin Injections for the Treatment of Limb Spasticity and Focal Dystonia Recruiting NCT02334683
25 Validation of the Zigzag Tracking Task Test for the Evaluation of Handwriting Difficulties in Writer's Cramp Recruiting NCT02882295
26 Brain Networks in Dystonia Enrolling by invitation NCT03042962
27 Depotentiation in People With Focal Hand Dystonia Terminated NCT02106936
28 Brain Anatomy in Dystonia Terminated NCT00031369

Search NIH Clinical Center for Focal Hand Dystonia

Genetic Tests for Focal Hand Dystonia

Anatomical Context for Focal Hand Dystonia

MalaCards organs/tissues related to Focal Hand Dystonia:

39
Brain, Cortex, Testes, Cerebellum

Publications for Focal Hand Dystonia

Articles related to Focal Hand Dystonia:

(show all 37)
id Title Authors Year
1
A prognostic factor in focal hand dystonia: typist's cramp cases and literature review. ( 27871456 )
2016
2
A neuromorphic model of motor overflow in focal hand dystonia due to correlated sensory input. ( 27578228 )
2016
3
Haptic Feedback Manipulation During Botulinum Toxin Injection Therapy for Focal Hand Dystonia Patients: A Possible New Assistive Strategy. ( 28113638 )
2016
4
Objective Evaluation of Performance Stress in Musicians With Focal Hand Dystonia: A Case Series. ( 27715491 )
2016
5
Haptic Feedback Manipulation During Botulinum Toxin Injection Therapy for Focal Hand Dystonia Patients: A Possible New Assistive Strategy. ( 27552765 )
2016
6
An unusual cause of focal hand dystonia due to a retained implant of the distal radius. ( 26746833 )
2016
7
Non-Invasive Brain Stimulation for Treatment of Focal Hand Dystonia: Update and Future Direction. ( 27240806 )
2016
8
Anodal transcranial direct current stimulation to the cerebellum improves handwriting and cyclic drawing kinematics in focal hand dystonia. ( 26042019 )
2015
9
A practical approach to management of focal hand dystonia. ( 26019409 )
2015
10
Mixed effectiveness of rTMS and retraining in the treatment of focal hand dystonia. ( 26217209 )
2015
11
Normalizing Biased Spatial Attention With Parietal rTMS in a Patient With Focal Hand Dystonia. ( 25178660 )
2014
12
Primary somatosensory cortical plasticity and tactile temporal discrimination in focal hand dystonia. ( 24012050 )
2014
13
Multiple changes of functional connectivity between sensorimotor areas in focal hand dystonia. ( 24706945 )
2014
14
Focal hand dystonia: individualized intervention with repeated application of repetitive transcranial magnetic stimulation. ( 25256555 )
2014
15
Focal hand dystonia: using brain stimulation to probe network interactions and brain plasticity. ( 25042177 )
2014
16
A multifactorial conceptual model of peripheral neuromusculoskeletal predisposing factors in task-specific focal hand dystonia in musicians: etiologic and therapeutic implications. ( 25323627 )
2014
17
Sensory abnormalities in focal hand dystonia and non-invasive brain stimulation. ( 25538594 )
2014
18
Temporal expectation in focal hand dystonia. ( 23361064 )
2013
19
Complex-value coherence mapping reveals novel abnormal resting-state functional connectivity networks in task-specific focal hand dystonia. ( 24133480 )
2013
20
Alteration in forward model prediction of sensory outcome of motor action in focal hand dystonia. ( 23882198 )
2013
21
Abnormal experimentally- and behaviorally-induced LTP-like plasticity in focal hand dystonia. ( 23142185 )
2013
22
Utility of multi-channel surface electromyography in assessment of focal hand dystonia. ( 23861190 )
2013
23
Aristotle's illusion reveals interdigit functional somatosensory alterations in focal hand dystonia. ( 23404333 )
2013
24
Treatment effectiveness of brain-computer interface training for patients with focal hand dystonia: A double-case study. ( 24109677 )
2013
25
Abnormal movement preparation in task-specific focal hand dystonia. ( 24167610 )
2013
26
A combination of constraint-induced therapy and motor control retraining in the treatment of focal hand dystonia in musicians: a long-term follow-up study. ( 23462903 )
2013
27
Focal hand dystonia in musicians: a synopsis. ( 23515596 )
2013
28
Multiple sessions of low-frequency repetitive transcranial magnetic stimulation in focal hand dystonia: clinical and physiological effects. ( 23340117 )
2013
29
Individuated finger control in focal hand dystonia: an fMRI study. ( 22484405 )
2012
30
Aberrant Oscillatory Activity during Simple Movement in Task-Specific Focal Hand Dystonia. ( 23226140 )
2012
31
Differential activation in the primary motor cortex during individual digit movement in focal hand dystonia vs. healthy. ( 22451345 )
2012
32
Difference in intracortical inhibition of the motor cortex between cortical myoclonus and focal hand dystonia. ( 18387338 )
2008
33
Focal hand dystonia in a patient with PANK2 mutation. ( 18074375 )
2008
34
Effect of thalamotomy on focal hand dystonia in a family with DYT1 mutation. ( 18823049 )
2008
35
Focal hand dystonia secondary to Basal Ganglia germinoma. ( 19513283 )
2007
36
Treatment of cervical dystonia and focal hand dystonia by high cervical continuously infused intrathecal baclofen: a report of 2 cases. ( 15827940 )
2005
37
Focal hand dystonia in a patient with thoracic outlet syndrome. ( 9703190 )
1998

Variations for Focal Hand Dystonia

Expression for Focal Hand Dystonia

Search GEO for disease gene expression data for Focal Hand Dystonia.

Pathways for Focal Hand Dystonia

GO Terms for Focal Hand Dystonia

Biological processes related to Focal Hand Dystonia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 reactive oxygen species metabolic process GO:0072593 8.96 DRD5 PDGFB
2 negative regulation of blood pressure GO:0045776 8.62 DRD5 RNPEP

Sources for Focal Hand Dystonia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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