MCID: FCL041
MIFTS: 45

Focal Myositis malady

Categories: Neuronal diseases, Rare diseases, Bone diseases

Aliases & Classifications for Focal Myositis

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Sources:
51Orphanet, 65UMLS, 28ICD10 via Orphanet, 66UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Focal Myositis:

Name: Focal Myositis 51
Focal Nodular Myositis 51 65
 
Inflammatory Pseudotumor of Skeletal Muscle 51
Myositis, Focal 65

Characteristics:

Orphanet epidemiological data:

51
focal nodular myositis:
Inheritance: Not applicable; Prevalence: <1/1000000 (Worldwide); Age of onset: Adult; Age of death: normal life expectancy

Classifications:



External Ids:

Orphanet51 48918
ICD10 via Orphanet28 M60.8
UMLS via Orphanet66 C0751357
UMLS65 C0751357, C0409988

Summaries for Focal Myositis

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MalaCards based summary: Focal Myositis, also known as focal nodular myositis, is related to vasculitis and myositis, and has symptoms including myopathy, myositis and muscle weakness. An important gene associated with Focal Myositis is MMP2 (Matrix Metallopeptidase 2), and among its related pathways are Bladder cancer and Validated transcriptional targets of AP1 family members Fra1 and Fra2. Affiliated tissues include skeletal muscle, bone and breast, and related mouse phenotypes are tumorigenesis and hematopoietic system.

Related Diseases for Focal Myositis

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Diseases related to Focal Myositis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 83)
idRelated DiseaseScoreTop Affiliating Genes
1vasculitis29.4MMP2, MMP9
2myositis10.7
3bullous pemphigoid10.1MMP7, TGM2
4radiculopathy10.1
5leri pleonosteosis10.0MMP2, MMP9
6mixed extragonadal germ cell cancer10.0MMP2, MMP9
7renal pelvis adenocarcinoma10.0MMP2, MMP9
8fibrous meningioma10.0MMP2, MMP9
9intrahepatic cholangiocarcinoma10.0MMP2, MMP9
10parotid disease10.0MMP2, MMP9
11gastric squamous cell carcinoma10.0MMP2, MMP9
12hernia of ovary and fallopian tube10.0MMP2, MMP9
13common bile duct neoplasm10.0MMP2, MMP9
14odontoma9.9MMP2, MMP9
15adenosarcoma of the uterus9.9MMP2, MMP9
16gastrointestinal carcinoma9.9MMP2, MMP9
17flat retinoschisis9.9MMP2, MMP9
18abnormal pupillary function9.9MMP2, MMP9
19umbilical hernia9.9MMP2, MMP9
20urinary tract obstruction9.9MMP2, MMP9
21bone ameloblastoma9.9MMP2, MMP9
22myopathy9.9
23primary thrombocytopenia9.9MMP2, MMP9
24mannosidosis9.9MMP2, MMP9
25myeloid leukemia9.9MMP2, MMP9
26alcohol-induced mental disorder9.9MMP2, MMP9
27pediatric t-cell leukemia9.9MMP7, MMP9
28oral leukoplakia9.9MMP2, MMP9
29immunodeficiency 27b, mycobacteriosis, ad9.9MMP7, MMP9
30focal cortical dysplasia, taylor balloon cell type9.9MMP2, MMP9
31hypothalamic disease9.9MMP2, MMP9
32grade iii astrocytoma9.9MMP7, MMP9
33bladder urachal adenocarcinoma9.9MMP2, MMP9
34benign eccrine breast spiradenoma9.8MMP2, MMP9
35giant cell glioblastoma9.8MMP2, MMP9
36brachyolmia9.8MMP2, MMP9
37cervicitis9.8
38polymyositis9.8
39tenosynovitis of foot and ankle9.8MMP2, MMP9
40bronchopulmonary dysplasia9.8MMP7, MMP9
41congenital myasthenic syndrome9.8MMP2, MMP9
42hepatocellular adenoma9.8MMP2, MMP9
43accessory nerve disease9.8MMP2, MMP9
44cell type cancer9.8MMP2, MMP9
45mitochondrial metabolism disease9.8MMP2, MMP9
46small cell cancer of the lung, somatic9.7MMP2, MMP9
47localized osteosarcoma9.7MMP2, MMP9
48gliosarcoma9.7MMP2, MMP9
49rheumatoid arthritis9.7
50muscle hypertrophy9.7

Graphical network of the top 20 diseases related to Focal Myositis:



Diseases related to focal myositis

Symptoms for Focal Myositis

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Symptoms:

 51 (show all 9)
  • myopathy
  • myositis
  • abnormal muscle biopsy/muscle enzymes/cpk/ldh/aldolase/creatin phosphokinase
  • muscle weakness/flaccidity
  • myalgia/muscular pain
  • restricted joint mobility/joint stiffness/ankylosis
  • weight loss/loss of appetite/break in weight curve/general health alteration
  • fever/chilling
  • asthenia/fatigue/weakness

HPO human phenotypes related to Focal Myositis:

(show all 7)
id Description Frequency HPO Source Accession
1 myopathy hallmark (90%) HP:0003198
2 myositis hallmark (90%) HP:0100614
3 muscle weakness occasional (7.5%) HP:0001324
4 limitation of joint mobility occasional (7.5%) HP:0001376
5 weight loss occasional (7.5%) HP:0001824
6 myalgia occasional (7.5%) HP:0003326
7 abnormality of temperature regulation occasional (7.5%) HP:0004370

Drugs & Therapeutics for Focal Myositis

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Drugs for Focal Myositis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
PrednisoneapprovedPhase 2, Phase 3126753-03-25865
Synonyms:
(1S,2R,10S,11S,14R,15S)-14-hydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-3,6-diene-5,17-dione
(8S,9S,10R,13S,14S,17R)-17-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,9,12,14,15,16-octahydrocyclopenta[a]phenanthrene-3,11-dione
(8xi,9xi,14xi)-17,21-dihydroxypregna-1,4-diene-3,11,20-trione
.delta. E
.delta.(sup1)-Cortisone
.delta.-Cortelan
.delta.-Cortisone
.delta.-Cortone
.delta.-E
.delta.1-Cortisone
.delta.1-Dehydrocortisone
.delta.sone
1,2-Dehydrocortisone
1,4-Pregnadiene-17-alpha,21-diol-3,11,20-trione
1,4-Pregnadiene-17.alpha.,21-diol-3,11,20-trione
1,4-Pregnadiene-17alpha,21-diol-3,11,20-trione
1-Cortisone
1-Dehydrocortisone
17,21-Dihydroxypregna-1,4-diene-3,11,20-trione
17alpha,21-Dihydroxy-1,4-pregnadiene-3,11,20-trione
53-03-2
68-59-7
81552_FLUKA
AC-11112
AC1L1LB2
AC1Q29EZ
ACon0_000082
ACon1_000297
AI3-52939
Adasone
Ancortone
Apo-Prednisone
Apo-prednisone
BPBio1_000323
BRD-K85883481-001-04-2
BSPBio_000293
Betapar
Bicortone
Bio-0649
C07370
C21H26O5
CCRIS 2646
CHEBI:8382
CHEMBL635
CID5865
CPD001227202
Cartancyl
Colisone
Cortan
Cortancyl
Cortidelt
Cotone
DB00635
Dacorten
Dacortin
Decortancyl
Decortin
Decortisyl
Dehydrocortisone
Dekortin
Delcortin
Dellacort
Dellacort A
Delta Cortelan
Delta E
Delta E.
Delta-Cortelan
Delta-Dome
Delta-cortelan
Delta-cortisone
Delta-cortone
Delta-dome
Deltacortene
Deltacortisone
Deltacortone
Deltasone
Deltasone, Liquid Pred, Orasone, Adasone, Deltacortisone,Prednisone
Deltison
Deltisona
Deltisone
Deltra
Di-Adreson
Diadreson
EINECS 200-160-3
Econosone
Encorton
Encortone
Enkortolon
Enkorton
Fernisone
Fiasone
HMS1568O15
HMS2090J13
HSDB 3168
Hostacortin
In-Sone
Incocortyl
Juvason
 
Kortancyl
LMST02030180
LS-1325
Liquid Pred
Lisacort
Lodotra
MEGxm0_000443
MLS001061265
MLS001304073
MLS001335907
MLS001335908
MLS002154191
MLS002207083
Me-Korti
Metacortandracin
Meticorten
Meticorten (Veterinary)
Metrevet (Veterinary)
MolPort-001-740-041
NCGC00090766-01
NCGC00090766-02
NCGC00090766-03
NCI-C04897
NCI60_000008
NSC 10023
NSC10023
Nisona
Nizon
Novoprednisone
Nurison
Orasone
Origen Prednisone
P1276
P6254_SIGMA
PRD
Panafcort
Panasol
Paracort
Parmenison
Pehacort
Perrigo Prednisone
Precort
Predeltin
Prednicen-M
Prednicorm
Prednicort
Prednicot
Prednidib
Prednilonga
Prednison
Prednisona
Prednisona [INN-Spanish]
Prednisone
Prednisone Intensol
Prednisone [INN:BAN]
Prednisonum
Prednisonum [INN-Latin]
Prednitone
Prednizon
Prednovister
Presone
Prestwick0_000077
Prestwick1_000077
Prestwick2_000077
Prestwick3_000077
Prestwick_405
Pronison
Pronisone
Rayos
Rectodelt
Retrocortine
S1622_Selleck
SAM002264641
SK-Prednisone
SMR000718760
SMR001227202
SPBio_002214
Servisone
Sone
Sterapred
Supercortil
U 6020
UNII-VB0R961HZT
Ultracorten
Ultracortene
WLN: L E5 B666 CV OV AHTTT&J A1 E1 FV1Q FQ
Winpred
Wojtab
ZINC03875357
Zenadrid
Zenadrid (veterinary)
Zenadrid [veterinary]
delta cortelan
delta(sup 1)-Cortisone
delta(sup 1)-Dehydrocortisone
delta-1-Cortisone
delta-1-Dehydrocortisone
delta-Cortisone
delta-Cortone
2
MethotrexateapprovedPhase 2, Phase 314441959-05-2, 59-05-2126941
Synonyms:
4-amino-10-methylfolic acid
4-amino-N(10)-Methylpteroylglutamic acid
Abitrexate
Amethopterin
Amethopterine
Antifolan
Arbitrexate
Emtexate
Folex
HDMTX
L-Amethopterin
Ledertrexate
MTX
Metatrexan
Methopterin
Methotextrate
 
Methotrate
Methotrexat
Methotrexate
Methotrexate Sodium
Methotrexatum
Methylaminopterin
Methylaminopterinum
Metoject
Metotrexato
Mexate
Méthotrexate
N-Bismethylpteroylglutamic Acid
N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acid
Otrexup
Rasuvo
Rheumatrex
Rheumatrex Dose Pack
Trexall
3
Etanerceptapproved, investigationalPhase 2, Phase 3383185243-69-0
Synonyms:
185243-69-0
CD120b
D00742
Enbrel
Enbrel (TN)
Enbrel Sureclick
Etanercept
Etanercept (USAN/INN)
 
Etanercept (genetical recombination)
Etanercept (genetical recombination) (JAN)
TNF-R2
Tumor necrosis factor receptor 2
Tumor necrosis factor receptor superfamily member 1B precursor
Tumor necrosis factor receptor type II
etanercept
p75
p80 TNF-alpha receptor
4Calcium, Dietary4678

Interventional clinical trials:

idNameStatusNCT IDPhase
1Understanding the Pathogenesis and Treatment of Childhood Onset DermatomyositisTerminatedNCT00035958Phase 2, Phase 3
2myoARRAY and TcLandscape Analysis for the Diagnosis of Inflammatory MyopathiesCompletedNCT00213629
3Endomysial Fibrosis, Muscular Inflammatory Response and Calcium Homeostasis Dysfunction in Duchenne Muscular DystrophyRecruitingNCT01823783

Search NIH Clinical Center for Focal Myositis

Genetic Tests for Focal Myositis

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Anatomical Context for Focal Myositis

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MalaCards organs/tissues related to Focal Myositis:

33
Skeletal muscle, Bone, Breast, T cells, Endothelial, Tongue, Lung

Animal Models for Focal Myositis or affiliated genes

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MGI Mouse Phenotypes related to Focal Myositis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.2MMP2, MMP7, MMP9, TGM2
2MP:00053978.0MMP2, MMP7, MMP9, TGM2
3MP:00053857.9MMP2, MMP7, MMP9, TGM2
4MP:00053877.7MMP2, MMP7, MMP9, TGM2

Publications for Focal Myositis

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Articles related to Focal Myositis:

(show top 50)    (show all 115)
idTitleAuthorsYear
1
Focal Myositis in paediatric age. (25878988)
2015
2
Ischaemia due to a vascular malformation causing focal myositis. (25155485)
2014
3
Recurrent Focal myositis: a rare inflammatory myopathy. (24859416)
2014
4
Clinical images: Focal myositis demonstrated on positron emission tomography. (24974825)
2014
5
Statin-induced focal myositis of the upper extremity. A report of two cases. (21232890)
2011
6
Focal myositis of the thigh misdiagnosed radiologically as rhabdomyosarcoma. (22700615)
2011
7
Recurrent focal myositis in an infant: a report of the youngest case. (21166916)
2010
8
All-trans retinoic acid-induced focal myositis, synovitis, and mononeuritis. (20009973)
2009
9
Focal myositis of the calf muscles. (19032842)
2008
10
Expression of transglutaminase 2 does not differentiate focal myositis from generalized inflammatory myopathies. (18005224)
2008
11
Dropped-head syndrome due to steroid responsive focal myositis: a case report and review of the literature. (17964603)
2008
12
Focal myositis of the calf following S1 radiculopathy. (18206215)
2008
13
Camptocormia associated with focal myositis in multiple-system atrophy. (16211611)
2006
14
Inflammatory focal myositis of the sternomastoid muscle: is there an absolute indication for biopsy? A case report and review of the literature. (16362267)
2006
15
Relapsing focal myositis: the localization detected by gallium citrate Ga 67 scintigraphy. (16344354)
2005
16
Fine needle aspiration cytology of focal myositis: a case report. (16450907)
2005
17
Focal myositis of the sternocleidomastoid muscle. (15632930)
2005
18
Focal myositis associated with S-1 radiculopathy: report of two cases. (14981746)
2004
19
Focal myositis in monozygotic twins. (15335189)
2004
20
A muscular lesion suggestive of focal myositis in a child with Proteus syndrome. (12439276)
2002
21
Focal myositis of the thigh: unusual MR pattern. (11981609)
2002
22
Focal myositis. (11531762)
2001
23
Becker muscular dystrophy associated with focal myositis on bone scintigraphy. (11129135)
2000
24
Focal myositis in the mylohyoid muscle of an adult. (10709172)
2000
25
Focal myositis - a new presentation. (10706844)
2000
26
Focal myositis: a review of 100 previously published cases and a report of 2 new cases. (10544855)
1999
27
Focal myositis presenting with radial nerve palsy. (10398220)
1999
28
Focal myositis: a new HLA-DR4 0401 associated disease? (10555921)
1999
29
S-1 radiculopathy as a possible predisposing factor in focal myositis with unilateral hypertrophy of the calf muscles. (10540038)
1999
30
Focal myositis. (9638840)
1998
31
Focal myositis: a polymerase chain reaction analysis for a viral etiology. (9013843)
1997
32
Focal myositis of the floor of mouth: report of two cases and review of the literature. (8734704)
1996
33
Focal myositis presenting as pseudothrombophlebitis of the neck in a patient with mixed connective tissue disease. (8670340)
1996
34
Relapsing focal myositis: a case report. (7554571)
1995
35
Focal myositis: a clinicopathological study. (7580245)
1995
36
Focal myositis: another cause of pseudothrombophlebitis. (8068109)
1994
37
Focal myositis of the temporal muscle. (8232395)
1993
38
Focal myositis of the thigh: report of two cases. (8256575)
1993
39
Focal myositis: an unusual cause of bilateral upper eyelid swellings. (8290436)
1993
40
Idiopathic recurrent non-suppurative focal myositis: a report of two cases. (8252323)
1993
41
Calf enlargement, S1 radiculopathy, and focal myositis. (1565123)
1992
42
Focal myositis. A new cause for the pediatric neck mass. (1986753)
1991
43
Squamous cell carcinoma masquerading as focal myositis of the tongue. (2753704)
1989
44
Focal myositis in the hand. (3351219)
1988
45
Focal myositis and its differential diagnosis. A case report and review of the literature. (3293581)
1988
46
Focal myositis and elevated creatine kinase levels in a patient with phaeochromocytoma. (3714605)
1986
47
Focal myositis mimicking posttreatment pain of periradicular origin. (3457896)
1986
48
Focal myositis of the tongue: report of a case. (3869221)
1985
49
Focal myositis of the neck. (468219)
1979
50
Focal myositis. (880559)
1977

Variations for Focal Myositis

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Expression for genes affiliated with Focal Myositis

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Search GEO for disease gene expression data for Focal Myositis.

Pathways for genes affiliated with Focal Myositis

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GO Terms for genes affiliated with Focal Myositis

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Biological processes related to Focal Myositis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1embryo implantationGO:00075669.5MMP2, MMP9
2ephrin receptor signaling pathwayGO:00480139.4MMP2, MMP9
3collagen catabolic processGO:00305749.1MMP2, MMP9
4proteolysisGO:00065089.1MMP2, MMP9
5extracellular matrix disassemblyGO:00226178.2MMP2, MMP7, MMP9

Molecular functions related to Focal Myositis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1zinc ion bindingGO:00082709.3MMP2, MMP7
2metalloendopeptidase activityGO:00042228.9MMP2, MMP7, MMP9

Sources for Focal Myositis

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet