MCID: FCL041
MIFTS: 37

Focal Myositis malady

Neuronal diseases, Rare diseases, Bone diseases categories

Aliases & Classifications for Focal Myositis

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Sources:
51Orphanet, 65UMLS, 28ICD10 via Orphanet, 66UMLS via Orphanet
See all sources

Aliases & Descriptions for Focal Myositis:

Name: Focal Myositis 51
Focal Nodular Myositis 51 65
 
Inflammatory Pseudotumor of Skeletal Muscle 51
Myositis, Focal 65


Classifications:



Characteristics (Orphanet epidemiological data):

51
focal nodular myositis:
Inheritance: Not applicable; Prevalence: <1/1000000 (Worldwide); Age of onset: Adult; Age of death: normal life expectancy


External Ids:

Orphanet51 48918
ICD10 via Orphanet28 M60.8
UMLS via Orphanet66 C0751357

Summaries for Focal Myositis

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MalaCards based summary: Focal Myositis, also known as focal nodular myositis, is related to myositis and radiculopathy, and has symptoms including myopathy, myositis and muscle weakness. An important gene associated with Focal Myositis is TGM2 (Transglutaminase 2), and among its related pathways are LPA receptor mediated events and amb2 Integrin signaling. Affiliated tissues include skeletal muscle, bone and tongue, and related mouse phenotypes are cardiovascular system and hematopoietic system.

Related Diseases for Focal Myositis

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Diseases related to Focal Myositis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 78)
idRelated DiseaseScoreTop Affiliating Genes
1myositis11.1
2radiculopathy10.4
3myopathy10.3
4cervicitis10.2
5polymyositis10.2
6rheumatoid arthritis10.1
7muscle hypertrophy10.1
8multiple system atrophy10.1
9becker muscular dystrophy10.1
10arthritis10.1
11mixed connective tissue disease10.1
12phaeochromocytoma10.1
13adenocarcinoma10.1
14connective tissue disease10.1
15esophagitis10.1
16fasciitis10.1
17mononeuritis10.1
18mononeuropathy10.1
19muscular dystrophy10.1
20panniculitis10.1
21rhabdomyosarcoma10.1
22sarcoma10.1
23synovitis10.1
24vasculitis10.1
25macroglossia10.1
26vascular malformation10.1
27paraneoplastic syndromes10.1
28leri pleonosteosis10.0MMP2, MMP9
29infiltrating angiolipoma10.0MMP2, MMP9
30tinea nigra10.0MMP2, MMP9
31fibrous meningioma10.0MMP2, MMP9
32ischemic colitis10.0MMP9, TGM2
33bronchiolo-alveolar adenocarcinoma10.0MMP2, MMP9
34hernia of ovary and fallopian tube10.0MMP2, MMP9
35adult botryoid rhabdomyosarcoma10.0MMP2, MMP9
36subacute leukemia10.0MMP2, MMP9
37adenosarcoma of the uterus10.0MMP2, MMP9
38odontoma10.0MMP2, MMP9
39lacrimal gland cancer10.0MMP2, MMP9
40coagulation protein disease10.0MMP2, MMP9
41neurofibromatosis, type 210.0MMP2, MMP9
42duodenum adenoma10.0MMP2, MMP9
43coronary stenosis10.0MMP2, MMP9
44conjunctivochalasis10.0MMP2, MMP9
45intestinal volvulus10.0MMP2, MMP9
46brachydactyly - arterial hypertension9.9MMP2, MMP9
47fungal meningitis9.9MMP2, MMP9
48brain injury9.9MMP7, MMP9
49ectopic pregnancy9.9MMP2, MMP9
50h. pylori infection9.9MMP7, MMP9

Graphical network of the top 20 diseases related to Focal Myositis:



Diseases related to focal myositis

Symptoms for Focal Myositis

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Symptoms:

 51 (show all 9)
  • myopathy
  • myositis
  • abnormal muscle biopsy/muscle enzymes/cpk/ldh/aldolase/creatin phosphokinase
  • muscle weakness/flaccidity
  • myalgia/muscular pain
  • restricted joint mobility/joint stiffness/ankylosis
  • weight loss/loss of appetite/break in weight curve/general health alteration
  • fever/chilling
  • asthenia/fatigue/weakness

HPO human phenotypes related to Focal Myositis:

(show all 7)
id Description Frequency HPO Source Accession
1 myopathy hallmark (90%) HP:0003198
2 myositis hallmark (90%) HP:0100614
3 muscle weakness occasional (7.5%) HP:0001324
4 limitation of joint mobility occasional (7.5%) HP:0001376
5 weight loss occasional (7.5%) HP:0001824
6 myalgia occasional (7.5%) HP:0003326
7 abnormality of temperature regulation occasional (7.5%) HP:0004370

Drugs & Therapeutics for Focal Myositis

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Drugs for Focal Myositis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
MethotrexateapprovedPhase 2, Phase 313871959-05-2, 59-05-2126941
Synonyms:
4-amino-10-methylfolic acid
4-amino-N(10)-Methylpteroylglutamic acid
Abitrexate
Amethopterin
Amethopterine
Antifolan
Arbitrexate
Emtexate
Folex
HDMTX
L-Amethopterin
Ledertrexate
MTX
Metatrexan
Methopterin
Methotextrate
 
Methotrate
Methotrexat
Methotrexate
Methotrexate Sodium
Methotrexatum
Methylaminopterin
Methylaminopterinum
Metoject
Metotrexato
Mexate
Méthotrexate
N-Bismethylpteroylglutamic Acid
N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acid
Otrexup
Rasuvo
Rheumatrex
Rheumatrex Dose Pack
Trexall
2
PrednisoneapprovedPhase 2, Phase 3120853-03-25865
Synonyms:
(1S,2R,10S,11S,14R,15S)-14-hydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-3,6-diene-5,17-dione
(8S,9S,10R,13S,14S,17R)-17-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,9,12,14,15,16-octahydrocyclopenta[a]phenanthrene-3,11-dione
(8xi,9xi,14xi)-17,21-dihydroxypregna-1,4-diene-3,11,20-trione
.delta. E
.delta.(sup1)-Cortisone
.delta.-Cortelan
.delta.-Cortisone
.delta.-Cortone
.delta.-E
.delta.1-Cortisone
.delta.1-Dehydrocortisone
.delta.sone
1,2-Dehydrocortisone
1,4-Pregnadiene-17-alpha,21-diol-3,11,20-trione
1,4-Pregnadiene-17.alpha.,21-diol-3,11,20-trione
1,4-Pregnadiene-17alpha,21-diol-3,11,20-trione
1-Cortisone
1-Dehydrocortisone
17,21-Dihydroxypregna-1,4-diene-3,11,20-trione
17alpha,21-Dihydroxy-1,4-pregnadiene-3,11,20-trione
53-03-2
68-59-7
81552_FLUKA
AC-11112
AC1L1LB2
AC1Q29EZ
ACon0_000082
ACon1_000297
AI3-52939
Adasone
Ancortone
Apo-Prednisone
Apo-prednisone
BPBio1_000323
BRD-K85883481-001-04-2
BSPBio_000293
Betapar
Bicortone
Bio-0649
C07370
C21H26O5
CCRIS 2646
CHEBI:8382
CHEMBL635
CID5865
CPD001227202
Cartancyl
Colisone
Cortan
Cortancyl
Cortidelt
Cotone
DB00635
Dacorten
Dacortin
Decortancyl
Decortin
Decortisyl
Dehydrocortisone
Dekortin
Delcortin
Dellacort
Dellacort A
Delta Cortelan
Delta E
Delta E.
Delta-Cortelan
Delta-Dome
Delta-cortelan
Delta-cortisone
Delta-cortone
Delta-dome
Deltacortene
Deltacortisone
Deltacortone
Deltasone
Deltasone, Liquid Pred, Orasone, Adasone, Deltacortisone,Prednisone
Deltison
Deltisona
Deltisone
Deltra
Di-Adreson
Diadreson
EINECS 200-160-3
Econosone
Encorton
Encortone
Enkortolon
Enkorton
Fernisone
Fiasone
HMS1568O15
HMS2090J13
HSDB 3168
Hostacortin
In-Sone
Incocortyl
Juvason
 
Kortancyl
LMST02030180
LS-1325
Liquid Pred
Lisacort
Lodotra
MEGxm0_000443
MLS001061265
MLS001304073
MLS001335907
MLS001335908
MLS002154191
MLS002207083
Me-Korti
Metacortandracin
Meticorten
Meticorten (Veterinary)
Metrevet (Veterinary)
MolPort-001-740-041
NCGC00090766-01
NCGC00090766-02
NCGC00090766-03
NCI-C04897
NCI60_000008
NSC 10023
NSC10023
Nisona
Nizon
Novoprednisone
Nurison
Orasone
Origen Prednisone
P1276
P6254_SIGMA
PRD
Panafcort
Panasol
Paracort
Parmenison
Pehacort
Perrigo Prednisone
Precort
Predeltin
Prednicen-M
Prednicorm
Prednicort
Prednicot
Prednidib
Prednilonga
Prednison
Prednisona
Prednisona [INN-Spanish]
Prednisone
Prednisone Intensol
Prednisone [INN:BAN]
Prednisonum
Prednisonum [INN-Latin]
Prednitone
Prednizon
Prednovister
Presone
Prestwick0_000077
Prestwick1_000077
Prestwick2_000077
Prestwick3_000077
Prestwick_405
Pronison
Pronisone
Rayos
Rectodelt
Retrocortine
S1622_Selleck
SAM002264641
SK-Prednisone
SMR000718760
SMR001227202
SPBio_002214
Servisone
Sone
Sterapred
Supercortil
U 6020
UNII-VB0R961HZT
Ultracorten
Ultracortene
WLN: L E5 B666 CV OV AHTTT&J A1 E1 FV1Q FQ
Winpred
Wojtab
ZINC03875357
Zenadrid
Zenadrid (veterinary)
Zenadrid [veterinary]
delta cortelan
delta(sup 1)-Cortisone
delta(sup 1)-Dehydrocortisone
delta-1-Cortisone
delta-1-Dehydrocortisone
delta-Cortisone
delta-Cortone
3TNFR-Fc fusion proteinPhase 2, Phase 3367
4Calcium, Dietary3529

Interventional clinical trials:

idNameStatusNCT IDPhase
1Understanding the Pathogenesis and Treatment of Childhood Onset DermatomyositisTerminatedNCT00035958Phase 2, Phase 3
2myoARRAY and TcLandscape Analysis for the Diagnosis of Inflammatory MyopathiesCompletedNCT00213629
3Endomysial Fibrosis, Muscular Inflammatory Response and Calcium Homeostasis Dysfunction in Duchenne Muscular DystrophyRecruitingNCT01823783

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Genetic Tests for Focal Myositis

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Anatomical Context for Focal Myositis

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MalaCards organs/tissues related to Focal Myositis:

33
Skeletal muscle, Bone, Tongue

Animal Models for Focal Myositis or affiliated genes

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MGI Mouse Phenotypes related to Focal Myositis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053858.1MMP2, MMP7, MMP9, TGM2
2MP:00053978.0MMP2, MMP7, MMP9, TGM2
3MP:00020067.9MMP2, MMP7, MMP9, TGM2
4MP:00053877.7MMP2, MMP7, MMP9, TGM2

Publications for Focal Myositis

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Articles related to Focal Myositis:

(show top 50)    (show all 112)
idTitleAuthorsYear
1
Focal Myositis in paediatric age. (25878988)
2015
2
Ischaemia due to a vascular malformation causing focal myositis. (25155485)
2014
3
Recurrent Focal myositis: a rare inflammatory myopathy. (24859416)
2014
4
Clinical images: Focal myositis demonstrated on positron emission tomography. (24974825)
2014
5
Statin-induced focal myositis of the upper extremity. A report of two cases. (21232890)
2011
6
Focal myositis of the thigh misdiagnosed radiologically as rhabdomyosarcoma. (22700615)
2011
7
Recurrent focal myositis in an infant: a report of the youngest case. (21166916)
2010
8
All-trans retinoic acid-induced focal myositis, synovitis, and mononeuritis. (20009973)
2009
9
Focal myositis of the calf muscles. (19032842)
2008
10
Expression of transglutaminase 2 does not differentiate focal myositis from generalized inflammatory myopathies. (18005224)
2008
11
Dropped-head syndrome due to steroid responsive focal myositis: a case report and review of the literature. (17964603)
2008
12
Focal myositis of the calf following S1 radiculopathy. (18206215)
2008
13
Camptocormia associated with focal myositis in multiple-system atrophy. (16211611)
2006
14
Inflammatory focal myositis of the sternomastoid muscle: is there an absolute indication for biopsy? A case report and review of the literature. (16362267)
2006
15
Relapsing focal myositis: the localization detected by gallium citrate Ga 67 scintigraphy. (16344354)
2005
16
Fine needle aspiration cytology of focal myositis: a case report. (16450907)
2005
17
Focal myositis of the sternocleidomastoid muscle. (15632930)
2005
18
Focal myositis associated with S-1 radiculopathy: report of two cases. (14981746)
2004
19
Focal myositis in monozygotic twins. (15335189)
2004
20
A muscular lesion suggestive of focal myositis in a child with Proteus syndrome. (12439276)
2002
21
Focal myositis of the thigh: unusual MR pattern. (11981609)
2002
22
Focal myositis. (11531762)
2001
23
Becker muscular dystrophy associated with focal myositis on bone scintigraphy. (11129135)
2000
24
Focal myositis in the mylohyoid muscle of an adult. (10709172)
2000
25
Focal myositis - a new presentation. (10706844)
2000
26
Focal myositis: a review of 100 previously published cases and a report of 2 new cases. (10544855)
1999
27
Focal myositis presenting with radial nerve palsy. (10398220)
1999
28
Focal myositis: a new HLA-DR4 0401 associated disease? (10555921)
1999
29
S-1 radiculopathy as a possible predisposing factor in focal myositis with unilateral hypertrophy of the calf muscles. (10540038)
1999
30
Focal myositis. (9638840)
1998
31
Focal myositis: a polymerase chain reaction analysis for a viral etiology. (9013843)
1997
32
Focal myositis of the floor of mouth: report of two cases and review of the literature. (8734704)
1996
33
Focal myositis presenting as pseudothrombophlebitis of the neck in a patient with mixed connective tissue disease. (8670340)
1996
34
Relapsing focal myositis: a case report. (7554571)
1995
35
Focal myositis: a clinicopathological study. (7580245)
1995
36
Focal myositis: another cause of pseudothrombophlebitis. (8068109)
1994
37
Focal myositis of the temporal muscle. (8232395)
1993
38
Focal myositis of the thigh: report of two cases. (8256575)
1993
39
Focal myositis: an unusual cause of bilateral upper eyelid swellings. (8290436)
1993
40
Idiopathic recurrent non-suppurative focal myositis: a report of two cases. (8252323)
1993
41
Calf enlargement, S1 radiculopathy, and focal myositis. (1565123)
1992
42
Focal myositis. A new cause for the pediatric neck mass. (1986753)
1991
43
Squamous cell carcinoma masquerading as focal myositis of the tongue. (2753704)
1989
44
Focal myositis in the hand. (3351219)
1988
45
Focal myositis and its differential diagnosis. A case report and review of the literature. (3293581)
1988
46
Focal myositis and elevated creatine kinase levels in a patient with phaeochromocytoma. (3714605)
1986
47
Focal myositis mimicking posttreatment pain of periradicular origin. (3457896)
1986
48
Focal myositis of the tongue: report of a case. (3869221)
1985
49
Focal myositis of the neck. (468219)
1979
50
Focal myositis. (880559)
1977

Variations for Focal Myositis

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Expression for genes affiliated with Focal Myositis

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Search GEO for disease gene expression data for Focal Myositis.

Pathways for genes affiliated with Focal Myositis

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GO Terms for genes affiliated with Focal Myositis

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Cellular components related to Focal Myositis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrixGO:00310128.5MMP2, MMP7, MMP9
2proteinaceous extracellular matrixGO:00055788.4MMP2, MMP7, MMP9

Biological processes related to Focal Myositis according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1ephrin receptor signaling pathwayGO:00480139.6MMP2, MMP9
2endodermal cell differentiationGO:00359879.6MMP2, MMP9
3embryo implantationGO:00075669.5MMP2, MMP9
4extracellular matrix disassemblyGO:00226178.6MMP2, MMP7, MMP9
5extracellular matrix organizationGO:00301988.5MMP2, MMP7, MMP9
6collagen catabolic processGO:00305748.4MMP2, MMP7, MMP9
7proteolysisGO:00065088.2MMP2, MMP7, MMP9

Molecular functions related to Focal Myositis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1metalloendopeptidase activityGO:00042228.8MMP2, MMP7, MMP9
2peptidase activityGO:00082338.7MMP7, MMP9
3metallopeptidase activityGO:00082378.5MMP2, MMP7, MMP9

Sources for Focal Myositis

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet