MCID: FCL041
MIFTS: 50

Focal Myositis malady

Neuronal diseases, Rare diseases, Bone diseases categories
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Summaries for Focal Myositis

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33MalaCards
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MalaCards: Focal Myositis, also known as focal nodular myositis, is related to arthritis and adenocarcinoma, and has symptoms including myositis, myalgia/muscular pain and weight loss/loss of appetite/break in weight curve/general health alteration. An important gene associated with Focal Myositis is MMP7 (matrix metallopeptidase 7 (matrilysin, uterine)), and among its related pathways are Syndecan-1-mediated signaling events and Collagen biosynthesis and modifying enzymes. The compounds flavanol and cgs-27023a have been mentioned in the context of this disorder. Affiliated tissues include skeletal muscle, tongue and bone, and related mouse phenotypes are renal/urinary system and tumorigenesis.

Aliases & Classifications for Focal Myositis

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49Orphanet, 62UMLS, 26ICD10 via Orphanet, 63UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Neuronal diseases, Bone diseases


Characteristics (Orphanet epidemiological data):

49
focal nodular myositis:
Inheritance: Sporadic; Prevalence: <1/1000000; Age of onset: Adulthood; Age of death: Normal


Aliases & Descriptions:

focal myositis 49
focal nodular myositis 49 62
inflammatory pseudotumor of skeletal muscle 49
myositis, focal 62


External Ids:

ICD10 via Orphanet26 M60.8
UMLS via Orphanet63 C0751357

Related Diseases for Focal Myositis

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17GeneCards, 18GeneDecks
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Diseases related to Focal Myositis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 61)
idRelated DiseaseScoreTop Affiliating Genes
1arthritis30.1MMP2, MMP9
2adenocarcinoma30.0MMP2, MMP9, MMP7
3myositis11.1
4radiculopathy10.4
5cervicitis10.2
6myopathy10.2
7polymyositis10.2
8prion disease10.1MMP2
9becker muscular dystrophy10.0
10proteus syndrome10.0
11mixed connective tissue disease10.0
12phaeochromocytoma10.0
13parkinson's disease10.0
14connective tissue disease10.0
15esophagitis10.0
16fasciitis10.0
17mononeuritis10.0
18multiple system atrophy10.0
19muscular dystrophy10.0
20panniculitis10.0
21rhabdomyosarcoma10.0
22rheumatoid arthritis10.0
23synovitis10.0
24vasculitis10.0
25macroglossia10.0
26paraneoplastic syndromes10.0
27endometriosis10.0MMP2, MMP7
28idiopathic pulmonary fibrosis10.0MMP9, MMP7
29tongue cancer10.0MMP9, MMP2
30conjunctivochalasis10.0MMP2, MMP9
31abdominal aortic aneurysm10.0MMP9, MMP2
32keratitis10.0MMP2, MMP9
33bladder carcinoma in situ10.0MMP2, MMP9
34aneurysm10.0MMP2, MMP9
35anaplastic astrocytoma10.0MMP2, MMP9
36oral cancer10.0MMP9, MMP2
37congenital heart disease10.0MMP2, MMP9
38cork-handlers' disease10.0MMP7, MMP9
39fibrosarcoma10.0MMP9, MMP2
40malignant glioma10.0MMP2, MMP9
41periodontal disease10.0MMP2, MMP9, MMP7
42pulmonary fibrosis10.0MMP7, MMP9, MMP2
43lung adenocarcinoma10.0MMP7, MMP9, MMP2
44endometrial carcinoma10.0MMP7, MMP9, MMP2
45lung cancer10.0MMP7, MMP9, MMP2
46kidney cancer9.9MMP7, MMP9, MMP2
47ovarian cancer9.9MMP2, MMP9, MMP7
48non-small cell lung carcinoma9.9MMP7, MMP9, MMP2
49astrocytoma9.9MMP2, MMP9, DMD
50stomach cancer9.9MMP2, MMP9, MMP7

Graphical network of the top 20 diseases related to Focal Myositis:



Diseases related to focal myositis

Symptoms for Focal Myositis

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49Orphanet
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Symptoms:

49 (show all 9)
  • myositis
  • myalgia/muscular pain
  • weight loss/loss of appetite/break in weight curve/general health alteration
  • abnormal muscle biopsy/muscle enzymes/cpk/ldh/aldolase/creatin phosphokinase
  • fever/chilling
  • asthenia/fatigue/weakness
  • myopathy
  • restricted joint mobility/joint stiffness/ankylosis
  • muscle weakness/flaccidity

Drugs & Therapeutics for Focal Myositis

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42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Focal Myositis

Search NIH Clinical Center for Focal Myositis

Genetic Tests for Focal Myositis

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Anatomical Context for Focal Myositis

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33MalaCards
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MalaCards organs/tissues related to Focal Myositis:

33
Skeletal muscle, Tongue, Bone

Animal Models for Focal Myositis or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Focal Myositis:

37 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.6MMP9, TGM2, DMD
2MP:00020068.3TGM2, MMP7, MMP9, MMP2
3MP:00053918.2DMD, MMP7, MMP9, MMP2
4MP:00053848.1MMP9, MMP7, TGM2, DMD
5MP:00053857.8MMP2, MMP9, MMP7, TGM2, DMD
6MP:00053977.8DMD, TGM2, MMP7, MMP9, MMP2
7MP:00053877.7MMP2, MMP9, MMP7, TGM2, DMD
8MP:00036317.7DMD, TGM2, MMP9, MMP2
9MP:00053787.7DMD, TGM2, MMP7, MMP9, MMP2
10MP:00053767.6MMP2, MMP9, MMP7, TGM2, DMD
11MP:00107687.5DMD, TGM2, MMP7, MMP9, MMP2

Publications for Focal Myositis

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52PubMed
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Articles related to Focal Myositis:

(show top 50)    (show all 104)
idTitleAuthorsYear
1
Statin-induced focal myositis of the upper extremity. A report of two cases. (21232890)
2011
2
Focal myositis of the thigh misdiagnosed radiologically as rhabdomyosarcoma. (22700615)
2011
3
Focal myositis of unilateral leg. (22506226)
2011
4
Recurrent focal myositis in an infant: a report of the youngest case. (21166916)
2010
5
All-trans retinoic acid-induced focal myositis, synovitis, and mononeuritis. (20009973)
2009
6
Focal myositis of the tongue presenting as macroglossia. (20055851)
2009
7
Focal myositis of the calf muscles. (19032842)
2008
8
Expression of transglutaminase 2 does not differentiate focal myositis from generalized inflammatory myopathies. (18005224)
2008
9
Dropped-head syndrome due to steroid responsive focal myositis: a case report and review of the literature. (17964603)
2008
10
Focal myositis of the calf following S1 radiculopathy. (18206215)
2008
11
Camptocormia associated with focal myositis in multiple-system atrophy. (16211611)
2006
12
Inflammatory focal myositis of the sternomastoid muscle: is there an absolute indication for biopsy? A case report and review of the literature. (16362267)
2006
13
Relapsing focal myositis: the localization detected by gallium citrate Ga 67 scintigraphy. (16344354)
2005
14
Fine needle aspiration cytology of focal myositis: a case report. (16450907)
2005
15
Focal myositis of the sternocleidomastoid muscle. (15632930)
2005
16
Focal myositis associated with S-1 radiculopathy: report of two cases. (14981746)
2004
17
Focal myositis in monozygotic twins. (15335189)
2004
18
Left gluteal focal myositis in a patient with signet ring adenocarcinoma of the stomach: not a paraneoplastic phenomenon. (14968264)
2004
19
A muscular lesion suggestive of focal myositis in a child with Proteus syndrome. (12439276)
2002
20
Focal myositis of the thigh: unusual MR pattern. (11981609)
2002
21
Focal myositis. (11531762)
2001
22
Becker muscular dystrophy associated with focal myositis on bone scintigraphy. (11129135)
2000
23
Focal myositis in the mylohyoid muscle of an adult. (10709172)
2000
24
Focal myositis - a new presentation. (10706844)
2000
25
Focal myositis: a review of 100 previously published cases and a report of 2 new cases. (10544855)
1999
26
Focal myositis presenting with radial nerve palsy. (10398220)
1999
27
Focal myositis: a new HLA-DR4 0401 associated disease? (10555921)
1999
28
S-1 radiculopathy as a possible predisposing factor in focal myositis with unilateral hypertrophy of the calf muscles. (10540038)
1999
29
Focal myositis. (9638840)
1998
30
Focal myositis: a polymerase chain reaction analysis for a viral etiology. (9013843)
1997
31
Focal myositis of the floor of mouth: report of two cases and review of the literature. (8734704)
1996
32
Focal myositis presenting as pseudothrombophlebitis of the neck in a patient with mixed connective tissue disease. (8670340)
1996
33
Relapsing focal myositis: a case report. (7554571)
1995
34
Focal myositis: a clinicopathological study. (7580245)
1995
35
Focal myositis of the tongue--a pseudotumoral lesion. (7797208)
1995
36
Focal myositis: another cause of pseudothrombophlebitis. (8068109)
1994
37
Focal myositis of the temporal muscle. (8232395)
1993
38
Focal myositis of the thigh: report of two cases. (8256575)
1993
39
Focal myositis: an unusual cause of bilateral upper eyelid swellings. (8290436)
1993
40
Idiopathic recurrent non-suppurative focal myositis: a report of two cases. (8252323)
1993
41
Calf enlargement, S1 radiculopathy, and focal myositis. (1565123)
1992
42
Focal myositis. A new cause for the pediatric neck mass. (1986753)
1991
43
Squamous cell carcinoma masquerading as focal myositis of the tongue. (2753704)
1989
44
Focal myositis in the hand. (3351219)
1988
45
Focal myositis and its differential diagnosis. A case report and review of the literature. (3293581)
1988
46
Focal myositis and elevated creatine kinase levels in a patient with phaeochromocytoma. (3714605)
1986
47
Focal myositis mimicking posttreatment pain of periradicular origin. (3457896)
1986
48
Focal myositis of the tongue: report of a case. (3869221)
1985
49
Focal myositis of the neck. (468219)
1979
50
Focal myositis. (880559)
1977

Variations for Focal Myositis

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Expression for genes affiliated with Focal Myositis

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Focal Myositis

Search GEO for disease gene expression data for Focal Myositis.

Pathways for genes affiliated with Focal Myositis

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Sources:
50PathCards, 38NCBI BioSystems Database, 55Reactome, 53QIAGEN, 30KEGG, 54R&D Systems, 60Thomson Reuters, 12EMD Millipore, 5Cell Signaling Technology
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Pathways related to Focal Myositis according to GeneCards/GeneDecks:

(show all 21)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.2MMP9, MMP7
2
Show member pathways
9.2MMP9, MMP7
39.0MMP2, MMP9
49.0MMP9, MMP2
59.0MMP9, MMP2
69.0MMP2, MMP9
79.0MMP2, MMP9
89.0MMP9, MMP2
99.0MMP2, MMP9
109.0MMP2, MMP9
119.0MMP2, MMP9
129.0MMP9, MMP2
13
Show member pathways
8.6MMP7, MMP9, MMP2
148.6MMP7, MMP9, MMP2
158.6MMP7, MMP9, MMP2
168.6MMP2, MMP9, MMP7
17
Show member pathways
8.6MMP2, MMP9, MMP7
188.6MMP2, MMP9, MMP7
19
Show member pathways
8.6MMP2, MMP9, MMP7
20
Show member pathways
8.6MMP2, MMP9, MMP7
21
Show member pathways
8.1MMP2, MMP9, MMP7, DMD

Compounds for genes affiliated with Focal Myositis

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Sources:
45Novoseek, 11DrugBank, 29IUPHAR, 3BitterDB, 61Tocris Bioscience, 24HMDB, 51PharmGKB
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Compounds related to Focal Myositis according to GeneCards/GeneDecks:

(show top 50)    (show all 76)
idCompoundScoreTop Affiliating Genes
1flavanol459.5MMP9, MMP2
2cgs-27023a459.5MMP9, MMP2
3col 3459.5MMP2, MMP9
4methyl selenol459.4MMP2, MMP9
5prinomastat459.4MMP9, MMP2
6trapidil459.4MMP2, MMP9
7lercanidipine45 1110.4MMP9, MMP2
8ilomastat459.4MMP9, MMP2
9tranilast459.4MMP2, MMP9
10gelfoam459.4MMP2, MMP9
11latanoprost45 1110.4MMP2, MMP9
12cilomilast459.4MMP2, MMP9
13hydroxamate459.4MMP2, MMP9
14zoledronic acid459.4MMP2, MMP9
15ciglitazone45 2910.3MMP2, MMP9
168-isoprostane459.3MMP9, MMP2
171,10-phenanthroline45 310.3MMP2, MMP9
18ns 39845 6110.3MMP2, MMP9
193-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide459.3MMP2, MMP9
20silymarin459.3MMP9, MMP2
21hydroxyproline45 24 1111.2MMP9, MMP2
22erythromycin45 3 51 1112.2MMP2, MMP9
23ivig459.1MMP2, MMP9
24ribavirin45 51 1111.1MMP2, MMP9
25doxycycline45 1110.0MMP9, MMP2
26celecoxib45 61 29 51 24 1114.0MMP2, MMP9
27hematoxylin459.0MMP9, DMD
28(4-aminophenyl)mercuric acetate459.0MMP2, MMP9, MMP7
29uk 383367619.0MMP7, MMP9, MMP2
30gi 254023x619.0MMP7, MMP9, MMP2
31gm 6001619.0MMP7, MMP9, MMP2
32fibrinogen459.0TGM2, MMP7, MMP9
33marimastat45 61 1111.0MMP2, MMP9, MMP7
34batimastat45 61 1111.0MMP2, MMP9, MMP7
35pioglitazone29 45 51 1112.0MMP2, MMP9, MMP7
36ag 1478459.0MMP7, MMP9, MMP2
37egcg459.0MMP2, MMP9, MMP7
38matrigel458.9MMP2, MMP9, MMP7
39ribonucleic acid458.9MMP2, MMP9, MMP7
40paraffin458.9MMP7, MMP9, MMP2
41succinate458.8MMP9, DMD
42proline458.8MMP2, MMP9, DMD
43creatinine458.7MMP2, MMP9, DMD
44zinc45 249.4DMD, MMP7, MMP9, MMP2
45retinoic acid45 249.4TGM2, MMP7, MMP9, MMP2
46alanine458.4DMD, TGM2, MMP9, MMP2
47tyrosine458.3MMP2, MMP9, MMP7, DMD
48cysteine458.0DMD, TGM2, MMP7, MMP9, MMP2
49serine458.0DMD, TGM2, MMP7, MMP9, MMP2
50calcium45 51 24 1110.9DMD, TGM2, MMP7, MMP9, MMP2

GO Terms for genes affiliated with Focal Myositis

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16Gene Ontology
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Cellular components related to Focal Myositis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.6MMP2, MMP9, MMP7
2proteinaceous extracellular matrixGO:0055788.3MMP2, MMP9, MMP7

Biological processes related to Focal Myositis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1embryo implantationGO:0075669.0MMP2, MMP9
2collagen catabolic processGO:0305748.6MMP2, MMP9, MMP7
3extracellular matrix disassemblyGO:0226178.5MMP7, MMP9, MMP2
4proteolysisGO:0065088.3MMP2, MMP9, MMP7
5extracellular matrix organizationGO:0301988.1MMP2, MMP9, MMP7, DMD

Molecular functions related to Focal Myositis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1metalloendopeptidase activityGO:0042228.3MMP2, MMP9, MMP7
2zinc ion bindingGO:0082708.1MMP2, MMP9, MMP7, DMD

Products for genes affiliated with Focal Myositis

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  • Antibodies
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  • Antibodies

Sources for Focal Myositis

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet