MCID: FCL041
MIFTS: 41

Focal Myositis malady

Categories: Neuronal diseases, Rare diseases, Bone diseases

Aliases & Classifications for Focal Myositis

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Sources:
52Orphanet, 29ICD10 via Orphanet, 67UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Focal Myositis:

Name: Focal Myositis 52
Inflammatory Pseudotumor of Skeletal Muscle 52
 
Focal Nodular Myositis 52

Characteristics:

Orphanet epidemiological data:

52
inflammatory pseudotumor of skeletal muscle:
Inheritance: Not applicable; Prevalence: <1/1000000 (Worldwide); Age of onset: Adult; Age of death: normal life expectancy

Classifications:



External Ids:

Orphanet52 ORPHA48918
ICD10 via Orphanet29 M60.8
UMLS via Orphanet67 C0751357

Summaries for Focal Myositis

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MalaCards based summary: Focal Myositis, also known as inflammatory pseudotumor of skeletal muscle, is related to cervicitis and myositis, and has symptoms including myopathy, myositis and muscle weakness. An important gene associated with Focal Myositis is MMP2 (Matrix Metallopeptidase 2), and among its related pathways are amb2 Integrin signaling and Bladder cancer. Affiliated tissues include skeletal muscle, tongue and bone, and related mouse phenotypes are immune system and neoplasm.

Related Diseases for Focal Myositis

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Diseases related to Focal Myositis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 97)
idRelated DiseaseScoreTop Affiliating Genes
1cervicitis28.8MMP2, MMP7, MMP9
2myositis10.7
3radiculopathy10.1
4myosin storage myopathy10.0MMP2, MMP9
5renal pelvis carcinoma10.0MMP2, MMP9
6meningothelial meningioma10.0MMP2, MMP9
7deletion 5q3510.0MMP2, MMP9
8sialadenitis10.0MMP2, MMP9
9penis squamous cell carcinoma10.0MMP2, MMP9
10cecum adenoma10.0MMP2, MMP9
11cyclosporiasis10.0MMP2, MMP9
12chemical colitis10.0MMP9, TGM2
13spindle epithelial tumor with thymus-like differentiation tumor10.0MMP2, MMP9
14tubular adenocarcinoma10.0MMP2, MMP9
15retinal degeneration10.0MMP2, MMP9
16intestinal benign neoplasm10.0MMP2, MMP9
17volkmann contracture10.0MMP2, MMP9
18adenosine monophosphate deaminase 1 deficiency9.9MMP2, MMP9
19schwannomatosis9.9MMP2, MMP9
20pauciarticular onset juvenile idiopathic arthritis9.9MMP2, MMP9
21benign hypertensive renal disease9.9MMP2, MMP9
22brucella canis brucellosis9.9MMP2, MMP9
23cavernous hemangioma of colon9.9MMP2, MMP9
24stromal keratitis9.9MMP2, MMP9
25mantle cell lymphoma9.9MMP2, MMP9
26retinal dystrophies primarily involving bruch's membrane9.9MMP2, MMP9
27pulmonary sarcoidosis9.9MMP2, MMP9
28myopathy9.9
29bone squamous cell carcinoma9.9MMP2, MMP9
30mastoiditis9.9MMP2, MMP9
31subacute monocytic leukemia9.9MMP2, MMP9
32malignant struma ovarii9.9MMP2, MMP9
33hodgkin's granuloma9.9MMP2, MMP9
34impetigo herpetiformis9.9MMP2, MMP9
35brain ischemia9.9MMP7, MMP9
36learning disability9.9MMP2, MMP9
37immunodeficiency 27b, mycobacteriosis, ad9.9MMP7, MMP9
38perrault syndrome9.9MMP2, MMP9
39juvenile astrocytoma9.9MMP7, MMP9
40lung hilum cancer9.9MMP2, MMP9
41chondroma9.9MMP2, MMP9
42multifocal choroiditis9.9MMP7, MMP9
43foveal hypoplasia 19.9MMP2, MMP9
44adult astrocytic tumour9.8MMP2, MMP9
45dysostosis9.8MMP2, MMP9
46tibialis tendinitis9.8MMP7, MMP9
47palmoplantar keratosis9.8MMP2, MMP9
48brown-vialetto-van laere syndrome9.8MMP2, MMP9
49polymyositis9.8
50odontoclasia9.8MMP2, MMP9

Graphical network of the top 20 diseases related to Focal Myositis:



Diseases related to focal myositis

Symptoms for Focal Myositis

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Symptoms:

 52 (show all 7)
  • muscle weakness
  • limitation of joint mobility
  • weight loss
  • fever
  • elevated serum creatine phosphokinase
  • myalgia
  • myositis

HPO human phenotypes related to Focal Myositis:

(show all 7)
id Description Frequency HPO Source Accession
1 myopathy hallmark (90%) HP:0003198
2 myositis hallmark (90%) HP:0100614
3 muscle weakness occasional (7.5%) HP:0001324
4 limitation of joint mobility occasional (7.5%) HP:0001376
5 weight loss occasional (7.5%) HP:0001824
6 myalgia occasional (7.5%) HP:0003326
7 abnormality of temperature regulation occasional (7.5%) HP:0004370

Drugs & Therapeutics for Focal Myositis

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Drugs for Focal Myositis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1glucocorticoidsPhase 2, Phase 34756
2
EtanerceptPhase 2, Phase 3391185243-69-0
Synonyms:
185243-69-0
CD120b
D00742
Enbrel
Enbrel (TN)
Enbrel Sureclick
Etanercept
Etanercept (USAN/INN)
 
Etanercept (genetical recombination)
Etanercept (genetical recombination) (JAN)
TNF-R2
Tumor necrosis factor receptor 2
Tumor necrosis factor receptor superfamily member 1B precursor
Tumor necrosis factor receptor type II
etanercept
p75
p80 TNF-alpha receptor
3
PrednisonePhase 2, Phase 3131853-03-25865
Synonyms:
(1S,2R,10S,11S,14R,15S)-14-hydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-3,6-diene-5,17-dione
(8S,9S,10R,13S,14S,17R)-17-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,9,12,14,15,16-octahydrocyclopenta[a]phenanthrene-3,11-dione
(8xi,9xi,14xi)-17,21-dihydroxypregna-1,4-diene-3,11,20-trione
.delta. E
.delta.(sup1)-Cortisone
.delta.-Cortelan
.delta.-Cortisone
.delta.-Cortone
.delta.-E
.delta.1-Cortisone
.delta.1-Dehydrocortisone
.delta.sone
1,2-Dehydrocortisone
1,4-Pregnadiene-17-alpha,21-diol-3,11,20-trione
1,4-Pregnadiene-17.alpha.,21-diol-3,11,20-trione
1,4-Pregnadiene-17alpha,21-diol-3,11,20-trione
1-Cortisone
1-Dehydrocortisone
17,21-Dihydroxypregna-1,4-diene-3,11,20-trione
17alpha,21-Dihydroxy-1,4-pregnadiene-3,11,20-trione
53-03-2
68-59-7
81552_FLUKA
AC-11112
AC1L1LB2
AC1Q29EZ
ACon0_000082
ACon1_000297
AI3-52939
Adasone
Ancortone
Apo-Prednisone
Apo-prednisone
BPBio1_000323
BRD-K85883481-001-04-2
BSPBio_000293
Betapar
Bicortone
Bio-0649
C07370
C21H26O5
CCRIS 2646
CHEBI:8382
CHEMBL635
CID5865
CPD001227202
Cartancyl
Colisone
Cortan
Cortancyl
Cortidelt
Cotone
DB00635
Dacorten
Dacortin
Decortancyl
Decortin
Decortisyl
Dehydrocortisone
Dekortin
Delcortin
Dellacort
Dellacort A
Delta Cortelan
Delta E
Delta E.
Delta-Cortelan
Delta-Dome
Delta-cortelan
Delta-cortisone
Delta-cortone
Delta-dome
Deltacortene
Deltacortisone
Deltacortone
Deltasone
Deltasone, Liquid Pred, Orasone, Adasone, Deltacortisone,Prednisone
Deltison
Deltisona
Deltisone
Deltra
Di-Adreson
Diadreson
EINECS 200-160-3
Econosone
Encorton
Encortone
Enkortolon
Enkorton
Fernisone
Fiasone
HMS1568O15
HMS2090J13
HSDB 3168
Hostacortin
In-Sone
Incocortyl
 
Juvason
Kortancyl
LMST02030180
LS-1325
Liquid Pred
Lisacort
Lodotra
MEGxm0_000443
MLS001061265
MLS001304073
MLS001335907
MLS001335908
MLS002154191
MLS002207083
Me-Korti
Metacortandracin
Meticorten
Meticorten (Veterinary)
Metrevet (Veterinary)
MolPort-001-740-041
NCGC00090766-01
NCGC00090766-02
NCGC00090766-03
NCI-C04897
NCI60_000008
NSC 10023
NSC10023
Nisona
Nizon
Novoprednisone
Nurison
Orasone
Origen Prednisone
P1276
P6254_SIGMA
PRD
Panafcort
Panasol
Paracort
Parmenison
Pehacort
Precort
Predeltin
Prednicen-M
Prednicorm
Prednicort
Prednicot
Prednidib
Prednilonga
Prednison
Prednisona
Prednisona [INN-Spanish]
Prednisone
Prednisone Intensol
Prednisone [INN:BAN]
Prednisonum
Prednisonum [INN-Latin]
Prednitone
Prednizon
Prednovister
Presone
Prestwick0_000077
Prestwick1_000077
Prestwick2_000077
Prestwick3_000077
Prestwick_405
Pronison
Pronisone
Rectodelt
Retrocortine
S1622_Selleck
SAM002264641
SK-Prednisone
SMR000718760
SMR001227202
SPBio_002214
Servisone
Sone
Sterapred
Supercortil
U 6020
UNII-VB0R961HZT
Ultracorten
Ultracortene
WLN: L E5 B666 CV OV AHTTT&J A1 E1 FV1Q FQ
Winpred
Wojtab
ZINC03875357
Zenadrid
Zenadrid (veterinary)
Zenadrid [veterinary]
delta cortelan
delta(sup 1)-Cortisone
delta(sup 1)-Dehydrocortisone
delta-1-Cortisone
delta-1-Dehydrocortisone
delta-Cortisone
delta-Cortone
4
MethotrexatePhase 2, Phase 314961959-05-2, 59-05-2126941
Synonyms:
4-amino-10-methylfolic acid
4-amino-N(10)-Methylpteroylglutamic acid
Abitrexate
Amethopterin
Amethopterine
Antifolan
Arbitrexate
Emtexate
Folex
HDMTX
L-Amethopterin
Ledertrexate
MTX
Metatrexan
 
Methopterin
Methotextrate
Methotrate
Methotrexat
Methotrexate Sodium
Methotrexatum
Methylaminopterin
Methylaminopterinum
Metotrexato
Mexate
Méthotrexate
N-Bismethylpteroylglutamic Acid
N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acid
Rheumatrex
Trexall
5
Folic AcidNutraceuticalPhase 2, Phase 3414359-30-36037
Synonyms:
(2S)-2-[[4-[(2-amino-4-oxo-1H-pteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid
01769_FLUKA
2d0k
33609-88-0
36653-55-1 (mono-potassium salt)
59-30-3
6484-89-5 (mono-hydrochloride salt)
AC-11682
AC1L1LNX
AI3-26387
AKOS000503224
ARONIS014410
Acfol (Spain)
Acide folique
Acide folique [INN-French]
Acido folico
Acido folico [INN-Spanish]
Acidum folicum
Acidum folicum [INN-Latin]
Acifolic
Antianemia factor
Apo-Folic
BIDD:ER0563
BIDD:GT0641
BIF0608
BPBio1_000654
BSPBio_000594
BSPBio_002338
C00504
C20H20N6O6
CAS-59-30-3
CCRIS 666
CHEBI:27470
CHEMBL1622
CID6037
CPD000471860
Cytofol
D00070
DB00158
DivK1c_000494
Dosfolat B activ
EINECS 200-419-0
F0043
F7876_SIAL
F7876_SIGMA
F8758_SIGMA
F8798_SIAL
F8890_SIGMA
FOL
Facid
Factor U
Folacid
Folacin
Folaemin
Folaemin [Netherlands]
Folan
Folasic (Australia)
Folate
Folbal
Folcidin
Folcidin (VAN)
Folcysteine
Foldine
Foldine [France]
Folettes
Foliamin
Folic
Folic acid
Folic acid (JP15/USP/INN)
Folic acid (TN)
Folic acid [BAN:INN:JAN]
Folic acid [INN:BAN:JAN]
Folic acid dihydrate
Folicet
Folicet (TN)
Folico
Folico (Italy)
Folina
Folina (Italy)
Folipac
Folsaeure
 
Folsan
Folsaure
Folsav
Folvite
Folvron
Glutamic acid, N-(p-(((2-amino-4-hydroxypyrimido(4,5-b)pyrazin-6-yl)methyl)amino)benzoyl)-, L
HMS1921D20
HMS2092N17
HMS501I16
HSDB 2002
IDI1_000494
InChI=1/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s
Incafolic
KBio1_000494
KBio2_001861
KBio2_004429
KBio2_006997
KBio3_001558
KBioGR_002222
KBioSS_001861
Kyselina listova
Kyselina listova [Czech]
LS-2157
Liver Lactobacillus casei factor
MLS001304016
MLS001335861
Millafol
Mission prenatal
Mittafol
MolPort-004-285-551
N-(4-(((2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzo- yl)-L-glutamic acid
N-(4-((2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid
N-(4-{[(2-Amino-4-oxo-3,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid
N-(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid
N-(p-(((2-Amino-4-hydroxy-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid
N-Pteroyl-L-glutamic acid
N-[(4-{[(2-Amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamic acid
N-[(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamic acid
N-[4-[[(2-Amino-3,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid
NCGC00016265-01
NCGC00142391-01
NINDS_000494
NSC 3073
Nifolin
Nifolin [Denmark]
Novofolacid
Novofolacid [Canada]
PGA
PGA (VAN)
Prestwick3_000627
Prestwick_230
PteGlu
Pteroyl-L-glutamate
Pteroyl-L-glutamic acid
Pteroyl-L-monoglutamate
Pteroyl-L-monoglutamic acid
Pteroylglutamate
Pteroylglutamic acid
Pteroylmonoglutamate
Pteroylmonoglutamic acid
SAM002264616
SDCCGMLS-0066738.P001
SMP2_000137
SMR000471860
SPBio_001357
SPECTRUM1502020
Serum Folate Level
Spectrum2_001459
Spectrum3_000749
Spectrum4_001751
Spectrum5_000602
Spectrum_001381
UNII-935E97BOY8
Usaf cb-13
Vitamin B11
Vitamin B9
Vitamin Bc
Vitamin Be
Vitamin M
bmse000299
folic acid
nchembio.108-comp10
6FolateNutraceuticalPhase 2, Phase 34143

Interventional clinical trials:

idNameStatusNCT IDPhase
1Understanding the Pathogenesis and Treatment of Childhood Onset DermatomyositisTerminatedNCT00035958Phase 2, Phase 3
2myoARRAY and TcLandscape Analysis for the Diagnosis of Inflammatory MyopathiesCompletedNCT00213629
3Acceptance and Commitment Therapy for Muscle DiseaseRecruitingNCT02810028
4Endomysial Fibrosis, Muscular Inflammatory Response and Calcium Homeostasis Dysfunction in Duchenne Muscular DystrophyRecruitingNCT01823783

Search NIH Clinical Center for Focal Myositis

Genetic Tests for Focal Myositis

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Anatomical Context for Focal Myositis

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MalaCards organs/tissues related to Focal Myositis:

34
Skeletal muscle, Tongue, Bone

Animal Models for Focal Myositis or affiliated genes

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MGI Mouse Phenotypes related to Focal Myositis:

39
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053878.2MMP2, MMP7, MMP9, TGM2
2MP:00020068.0MMP2, MMP7, MMP9, TGM2
3MP:00053858.0MMP2, MMP7, MMP9, TGM2
4MP:00053977.9MMP2, MMP7, MMP9, TGM2

Publications for Focal Myositis

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Articles related to Focal Myositis:

(show top 50)    (show all 115)
idTitleAuthorsYear
1
Focal myositis presenting as pseudothrombophlebitis of the arm. (26626630)
2016
2
Acute exacerbation of previously undiagnosed chronic focal myositis in an Aboriginal patient on maintenance haemodialysis. (25342033)
2014
3
Focal myositis of lower extremity responsive to botulinum A toxin. (24614669)
2014
4
Ultrasound-guided closed muscle biopsy: a useful tool for rheumatologists : case report: recurrent focal myositis of the gastrocnemius muscle. (22095391)
2013
5
Focal myositis--neurogenic phenomenon? (22153989)
2012
6
Focal myositis of the thigh misdiagnosed radiologically as rhabdomyosarcoma. (22700615)
2011
7
Focal myositis of unilateral leg. (22506226)
2011
8
Recurrent focal myositis in an infant: a report of the youngest case. (21166916)
2010
9
All-trans retinoic acid-induced focal myositis, synovitis, and mononeuritis. (20009973)
2009
10
Focal myositis of the tongue presenting as macroglossia. (20055851)
2009
11
Statin-associated focal myositis. (18155787)
2009
12
MR imaging findings of focal myositis: a pseudotumour that may mimic muscle neoplasm. (19255757)
2009
13
Expression of transglutaminase 2 does not differentiate focal myositis from generalized inflammatory myopathies. (18005224)
2008
14
Dropped-head syndrome due to steroid responsive focal myositis: a case report and review of the literature. (17964603)
2008
15
Camptocormia associated with focal myositis in multiple-system atrophy. (16211611)
2006
16
Focal myositis with fasciitis and vasculitis revealing chronic lymphocytic leukaemia. (15941726)
2005
17
Focal myositis associated with S-1 radiculopathy: report of two cases. (14981746)
2004
18
Focal myositis in monozygotic twins. (15335189)
2004
19
Left gluteal focal myositis in a patient with signet ring adenocarcinoma of the stomach: not a paraneoplastic phenomenon. (14968264)
2004
20
Focal myositis. Description of a case and review of the literature. (15382589)
2004
21
Reversible focal myositis in a patient taking venlafaxine. (15564641)
2004
22
A muscular lesion suggestive of focal myositis in a child with Proteus syndrome. (12439276)
2002
23
Focal myositis of the thigh: unusual MR pattern. (11981609)
2002
24
Focal myositis of the neck with idiopathic orbital myositis. (11945201)
2002
25
Focal myositis in the mylohyoid muscle of an adult. (10709172)
2000
26
Clinical and pathologic features of focal myositis. (11003793)
2000
27
Focal myositis presenting with radial nerve palsy. (10398220)
1999
28
Focal myositis: a new HLA-DR4 0401 associated disease? (10555921)
1999
29
S-1 radiculopathy as a possible predisposing factor in focal myositis with unilateral hypertrophy of the calf muscles. (10540038)
1999
30
The dropped head syndrome: rehabilitation of cervical focal myositis. (10608653)
1999
31
Focal myositis. (9638840)
1998
32
Magnetic resonance imaging in focal myositis. (9489838)
1998
33
Benign adult-onset focal myositis confined to the calf muscles. (9466607)
1998
34
Recurrent focal myositis. (9270685)
1997
35
Focal myositis of esophagus: a distinct inflammatory pseudotumor mimicking esophageal malignancy. (8995969)
1997
36
Focal myositis presenting as pseudothrombophlebitis of the neck in a patient with mixed connective tissue disease. (8670340)
1996
37
Focal myositis of the sternocleidomastoid muscle: a case report and review of the literature. (8827284)
1996
38
Relapsing focal myositis: a case report. (7554571)
1995
39
Focal myositis--a pseudotumoral lesion. (8181812)
1994
40
Focal myositis in a patient with bilateral painful nodules. (7813241)
1994
41
Focal myositis. A new cause for the pediatric neck mass. (1986753)
1991
42
Squamous cell carcinoma masquerading as focal myositis of the tongue. (2753704)
1989
43
Focal myositis of the tongue. (3478443)
1987
44
Focal myositis and elevated creatine kinase levels in a patient with phaeochromocytoma. (3714605)
1986
45
Focal myositis mimicking posttreatment pain of periradicular origin. (3457896)
1986
46
Cervical focal myositis in a child. (3701556)
1986
47
Focal myositis of the rectus abdominal muscles. (3157288)
1985
48
Focal myositis: a benign lesion that mimics malignant disease. A case report. (7142247)
1982
49
Denervating changes in focal myositis, a benign inflammatory pseudotumor. (6989340)
1980
50
Focal myositis of the neck. (468219)
1979

Variations for Focal Myositis

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Expression for genes affiliated with Focal Myositis

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Search GEO for disease gene expression data for Focal Myositis.

Pathways for genes affiliated with Focal Myositis

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GO Terms for genes affiliated with Focal Myositis

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Cellular components related to Focal Myositis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1proteinaceous extracellular matrixGO:00055788.5MMP2, MMP7, MMP9

Biological processes related to Focal Myositis according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1endodermal cell differentiationGO:00359879.6MMP2, MMP9
2embryo implantationGO:00075669.5MMP2, MMP9
3positive regulation of vascular smooth muscle cell proliferationGO:19047079.4MMP2, MMP9
4ephrin receptor signaling pathwayGO:00480139.4MMP2, MMP9
5collagen catabolic processGO:00305748.9MMP2, MMP7, MMP9
6extracellular matrix disassemblyGO:00226178.8MMP2, MMP7, MMP9
7proteolysisGO:00065088.5MMP2, MMP7, MMP9

Molecular functions related to Focal Myositis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1metallopeptidase activityGO:00082379.1MMP2, MMP9
2metalloendopeptidase activityGO:00042228.9MMP2, MMP7, MMP9
3serine-type endopeptidase activityGO:00042528.2MMP2, MMP7, MMP9

Sources for Focal Myositis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet