Focal Segmental Glomerulosclerosis malady

Wikipedia: Focal segmental glomerulosclerosis (FSGS) is a cause of nephrotic syndrome in children and adolescents,...⁴⁴ more...

MalaCards: Focal Segmental Glomerulosclerosis, also known as idiopathic (sporadic) focal segmental glomerulosclerosis (fsgs), is related to focal glomerulosclerosis and frasier syndrome. An important gene associated with Focal Segmental Glomerulosclerosis is ACTN4 (actinin, alpha 4), and among its related pathways are ACE Inhibitor Pathway, Pharmacodynamics and Cell adhesion_Endothelial cell contacts by non-junctional mechanisms. The drug cyclosporine and the compounds glucose and hyaluronic acid have been mentioned in the context of this disorder. Affiliated tissues include kidney, b cells and endothelial, and related mouse phenotypes are hematopoietic system and respiratory system.

Aliases & Descriptions:

focal segmental glomerulosclerosis 6 16 8 idiopathic (sporadic) focal segmental glomerulosclerosis (fsgs) 16 familial focal segmental glomerulosclerosis (ffsg) 16 glomerulosclerosis, focal segmental 32

glomerulosclerosis (disorder) 43 focal glomerulosclerosis 43 fsgs 6

Disease types for focal segmental glomerulosclerosis family:

focal segmental glomerulosclerosis 1	focal segmental glomerulosclerosis 2
focal segmental glomerulosclerosis 3	focal segmental glomerulosclerosis 5
glomerulosclerosis, focal segmental, 4

Diseases related to focal segmental glomerulosclerosis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 804)

id	Related Disease	Score	Top Affiliating Genes
1	focal glomerulosclerosis	35.0	ALB, ACE, NPHS2
2	frasier syndrome	32.0	CD2AP, WT1, ACTN4, NPHS2
3	hematuria	31.4	CD79A, COL4A3, COL4A4, ACE
4	hepatitis	30.1	IFNA1, IFNA2, ALB, SMAD3, TGFB1, TF
5	epidermolysis bullosa	30.1	VIM, CD79A, ITGB4, IL2RA, IGFBP3, TGFB1
6	hypertension	29.7	NOS2, ACE, AGT, AGTR1
7	nephrosis	29.3	LAMB2, IL10, IL6, ALB, TNF, NRF1
8	glomerulopathy	28.7	BMP6, CD79A, CD2AP, IL2RA, APOE, ALB
9	renovascular hypertension	28.6	ALB, TNF, EDN1, ACE, AGT, AGTR1
10	hepatitis c	28.0	IL10, IFNA1, IFNA2, IFNG, TNF, TGFB1
11	immunodeficiency	27.4	BMP6, CD79A, IL10, IL2RA, IL6, IFNA1
12	wilms tumor	27.0	VIM, BMP6, PAX2, MTHFR, CD2AP, CDKN1C
13	proteinuria	26.9	COG2, MYO1E, BMP6, PAX2, LAMB2, FYN
14	thrombocytopenia	25.8	BMP6, MTHFR, CD79A, IL10, IL6, IFNA1
15	familial hypercholesterolemia	25.6	COG2, MTHFR, IL10, IL6, APOE, IGF1
16	hypercholesterolemia	24.4	COG2, CHKA, MTHFR, CD79A, IL10, IL2RA
17	nephrotic syndrome	23.0	VIM, MYO1E, BMP6, PAX2, LAMB2, CD79A
18	blindness	22.9	COG2, MTHFR, CD79A, IL10, IL2RA, IL6
19	nephropathy	21.9	COG2, LMNA, BMP6, PAX2, MTHFR, LAMB2
20	leukemia	18.0	COG2, VIM, LMNA, BMP6, PAX2, CHKA
21	familial nephrotic syndrome	13.9	LAMB2, PLCE1, NPHS1
22	diffuse mesangial sclerosis	13.9	PAX2, LAMB2, PLCE1, WT1
23	nail-patella syndrome	13.8	PAX2, CD2AP, COL4A4, NPHS2
24	autosomal dominant alport syndrome	13.8	COL4A3, COL4A4, MYH9
25	hajdu-cheney syndrome	13.7	LMNA, ZMPSTE24, ALB
26	membranous glomerulonephritis	13.7	CD79A, CD2AP, ALB, NPHS1, NPHS2
27	alport syndrome	13.6	CD79A, COL4A3, COL4A4, MYH9
28	renal tubular dysgenesis	13.6	ACE, AGT, AGTR1
29	ovarian clear cell adenocarcinoma	13.6	GPX3, SMAD2, SMAD3, WT1
30	bronchiolitis obliterans organizing pneumonia	13.6	CHKA, IFNA2, ALB
31	clear cell adenocarcinoma	13.6	PAX2, GPX3, SMAD2, SMAD3, WT1
32	mitral valve disease	13.6	ACE, AGT, AGTR1
33	renal hypertension	13.6	ALB, EDN1, ACE
34	anuria	13.5	ALB, ACE, AGT, AGTR1
35	denys-drash syndrome	13.5	PAX2, CD2AP, WT1, TGFB1, NPHS1, NPHS2
36	congenital nephrotic syndrome finnish type	13.5	TTR, TF, NPHS1
37	mesangial sclerosis	13.5	PAX2, LAMB2, PLCE1, WT1, TGFB1, NPHS1
38	membranoproliferative glomerulonephritis type 2	13.5	CD79A, IFNA2, NPHS1
39	glomerulosclerosis	13.5
40	orthostatic hypotension	13.5	ALB, ACE, AGT, AGTR1
41	interstitial nephritis	13.5	ALB, ACE, AGT, AGTR1
42	fibromuscular dysplasia	13.5	ACE, AGT, AGTR1
43	hypertensive nephropathy	13.5	ALB, EDN1, ACE
44	nephroblastoma	13.5	VIM, PAX2, CDKN1C, WT1, SYNPO, NPHS1
45	hyperaldosteronism	13.4	ACE, AGT, AGTR1, SLC12A1
46	aortic coarctation	13.4	EDN1, ACE, AGT, AGTR1
47	hyperthyroxinemia	13.4	CD79A, ALB, TTR
48	cor pulmonale	13.4	GPX3, EDN1, ACE, AGTR1
49	diastolic heart failure	13.4	BMP6, ACE, AGT, AGTR1
50	chronic rapidly progressive glomerulonephritis	13.4	CD79A, ALB, ACE, AGTR1

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 cyclosporine

Genetic tests related to focal segmental glomerulosclerosis:

id	Genetic test	Affiliating Genes
1	Focal Segmental Glomerulosclerosis clinical/research	CD2AP, TRPC6, ACTN4

MalaCards organs/tissues related to focal segmental glomerulosclerosis:

²²

id	Organ / Tissue -> Anatomical Compartment -> Cell	Relevance
1	Kidney -> Podocyte Layer -> Podocytes	Potential therapeutic candidate, affected by disease

MGI Mouse Phenotypes related to focal segmental glomerulosclerosis:

²⁵ (show all 26)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system phenotype	MP:0005397	10.5	MYH9, SLC12A1, CD2AP, MYO1E
2	respiratory system phenotype	MP:0005388	10.2	APOE
3	craniofacial phenotype	MP:0005382	10.1	EDN1, SMAD3, CDKN1C, ZMPSTE24
4	embryogenesis phenotype	MP:0005380	9.9	TFAM, VIM
5	endocrine/exocrine gland phenotype	MP:0005379	9.6	WT1, IFNG, ITGA3, CDKN1C, PAX2
6	no phenotypic analysis	MP:0003012	9.4	MYH9, SMAD2, FMN1, CD79A, FYN, MTHFR
7	integument phenotype	MP:0010771	8.9	SLC12A1, SMAD2, TRPC6, IFNG, FMN1, ITGB4
8	liver/biliary system phenotype	MP:0005370	8.7	AGT, SMAD3, SMAD2, IFNG, IGFBP1, IL6
9	hearing/vestibular/ear phenotype	MP:0005377	8.6	EDN1, COL4A4, COL4A3, IGF1, APOE, ITGB4
10	nervous system phenotype	MP:0003631	8.5	EDN1, AGT, THBD, TGFB1, TFAM, SYNPO
11	limbs/digits/tail phenotype	MP:0005371	8.3	THBS1, SMAD3, APOE, IL10, FMN1, MMP14
12	skeleton phenotype	MP:0005390	7.9	IL6, IGF1, SMAD2, SMAD3, THBS1, SLC12A1
13	digestive/alimentary phenotype	MP:0005381	7.6	SMAD3, NOS2, COL4A4, EDN1, THBS1, TGFB1
14	renal/urinary system phenotype	MP:0005367	7.5	MYH9, SLC12A1, NPHS2, NPHS1, NPHP4, SYNPO
15	adipose tissue phenotype	MP:0005375	7.0	TGFB1, AGT, ACE, NOS2, TNF, IGF1
16	immune system phenotype	MP:0005387	6.6	MYH9, SLC12A1, THBS1, FYN, LAMB2, ZMPSTE24
17	tumorigenesis	MP:0002006	6.4	TGFB1, THBS1, ACE, NOS2, PLCE1, SMAD3
18	growth/size phenotype	MP:0005378	6.3	ACE, LAMB2, MTHFR, ZMPSTE24, BMP6, LMNA
19	reproductive system phenotype	MP:0005389	6.2	SMAD2, SMAD3, NOS2, WT1, AGT, THBS1
20	behavior/neurological phenotype	MP:0005386	5.7	TRPC6, PTPRO, SMAD2, SMAD3, NOS2, COL4A3
21	vision/eye phenotype	MP:0005391	5.2	NPHP4, MMP14, ITGB4, ITGB1, ITGA3, CDKN1C
22	muscle phenotype	MP:0005369	5.0	GNE, TRPC6, TNF, PLCE1, NOS2, WT1
23	homeostasis/metabolism phenotype	MP:0005376	4.8	SLC12A1, NPHS2, NPHS1, PON1, TFAM, TF
24	mortality/aging	MP:0010768	4.7	IL2RA, LMNA, FMN1, MMP14, ITGB4, ITGA3
25	cardiovascular system phenotype	MP:0005385	3.7	MYH9, SLC12A1, NPHS2, NPHP4, PON1, TFAM
26	cellular phenotype	MP:0005384	3.6	NOS2, SMAD3, SMAD2, NRF1, TNF, IFNG

Articles related to focal segmental glomerulosclerosis:

(show top 50)    (show all 115)

id	Title	Authors	Year	Affiliating Genes
1	MYO1E mutations and childhood familial focal segmental glomerulosclerosis. (21756023)	Mele C.... Noris M.	2011	MYO1E
2	Functional analysis of promoter mutations in the ACTN 4 and SYNPO genes in focal segmental glomerulosclerosis. (19666657)	Dai S.... Chen N.	2010	ACTN4, SYNPO
3	A novel WT1 gene mutation in a three-generation famil y with progressive isolated focal segmental glomerulosclerosis. (20150449)	Benetti E.... Murer L.	2010	WT1
4	ACTN4 gene mutations and single nucleotide polymorphi sms in idiopathic focal segmental glomerulosclerosis. (19142020)	Dai S.... Chen N.	2009	ACTN4
5	Very low-molecular-mass fragments of albumin in the p lasma of patients with focal segmental glomerulosclerosis. (19781833)	Hellin J.L.... Nieto J.L.	2009	ALB
6	Atypical phenotype of type I Bartter syndrome accompanied by focal segmental glomerulosclerosis. (18830715)	Yamazaki H.... Gejyo F.	2009	SLC12A1
7	TRPC6 mutations associated with focal segmental glomerulosclerosis cause constitutive activation of NFAT-dependent transcription. (19129465)	SchlAPndorff J.... Pollak M.R.	2009	TRPC6
8	Elevated asymmetric dimethylarginine (ADMA) and inverse correlation between circulating ADMA and glomerular filtration rate in children with sporadic focal segmental glomerulosclerosis (FSGS). (18175783)	LA1cke T.... Das A.M.	2008	NOS2
9	Bigenic heterozygosity and the development of steroid-resistant focal segmental glomerulosclerosis. (18443213)	Lowik M.... van den Heuvel L.	2008	WT1, ACTN4, TRPC6
10	Clinical features and mutational survey of NPHS2 (podocin) in Japanese children with focal segmental glomerulosclerosis who underwent renal transplantation. (18208440)	Furue T.... Sakano T.	2008	NPHS2
11	Angiotensin-converting enzyme gene polymorphism and the progression rate of focal segmental glomerulosclerosis in Iranian children. (19076285)	Gheissari A.... Naeini A.E.	2008	ACE
12	MYH9 is a major-effect risk gene for focal segmental glomerulosclerosis. (18794856)	Kopp J.B.... Winkler C.A.	2008	MYH9
13	Crystal structure of the actin-binding domain of alpha-actinin-4 Lys255Glu mutant implicated in focal segmental glomerulosclerosis. (18164029)	Lee S.H.... Dominguez R.	2008	ACTN4
14	Therapeutic targets in focal and segmental glomerulosclerosis. (18660675)	Lavin P.J.... Winn M.P.	2008	GNE
15	Functional genetic variation in aminopeptidase A (ENPEP): lack of clear association with focal and segmental glomerulosclerosis (FSGS). (18206321)	Tonna S.... Pollak M.R.	2008	ENPEP
16	NPHS2 variation in focal and segmental glomerulosclerosis. (18823551)	Tonna S.J.... Pollak M.R.	2008	NPHS2
17	Novel mutations in NPHP4 in a consanguineous family with histological findings of focal segmental glomerulosclerosis. (17954299)	Mistry K.... Pollak M.R.	2007	NPHP4
18	Synaptopodin immunoexpression in steroid-responsive and steroid-resistant minimal change disease and focal segmental glomerulosclerosis (18336100)	Wagrowska-Danilewicz M.... Danilewicz M.	2007	SYNPO
19	COL4A3/COL4A4 mutations producing focal segmental glomerulosclerosis and renal failure in thin basement membrane nephropathy. (17942953)	Voskarides K.... Deltas C.	2007	COL4A3, COL4A4
20	Posttransplant recurrence of proteinuria in a case of focal segmental glomerulosclerosis associated with WT1 mutation. (16780544)	Ghiggeri G.M.... Gesualdo L.	2006	ALB, WT1, NPHS2
21	Bigenic mouse models of focal segmental glomerulosclerosis involving pairwise interaction of CD2AP, Fyn, and synaptopodin. (16628251)	Huber T.B.... Shaw A.S.	2006	FYN, ACTN4, TRPC6
22	Recurrence of proteinuria 10 years post-transplant in NPHS2-associated focal segmental glomerulosclerosis after conversion from cyclosporin A to sirolimus. (16721582)	Hocker B.... Tonshoff B.	2006	NPHS2
23	NPHS2 mutations in adult patients with primary focal segmental glomerulosclerosis. (16874699)	Monteiro E.J.... Mastroianni-Kirsztajn G.	2006	NPHS2
24	Podocin-related mechanisms in posttransplant [corrected] recurrence of focal segmental glomerulosclerosis [corrected (17175312)	Caridi G.... Ghiggeri G.M.	2006	NPHS2
25	Interleukin-10 promoter polymorphism is associated with the predisposition to the development of IgA nephropathy and focal segmental glomerulosclerosis in Korea. (16361810)	Chin H.J.... Chae D.W.	2005	IL10
26	C5b-9 regulates peritubular myofibroblast accumulatio n in experimental focal segmental glomerulosclerosis. (15496154)	Rangan G.K.... Couser W.G.	2004	VIM
27	Influence of cytokine gene polymorphisms on focal segmental glomerulosclerosis. (15308875)	Bantis C.... Ivens K.	2004	TGFB1, TNF, IL6
28	Apolipoprotein E in idiopathic nephrotic syndrome and focal segmental glomerulosclerosis. (12631135)	Bruschi M.... Ghiggeri G.M.	2003	APOE
29	Recurrence of focal segmental glomerulosclerosis after renal transplantation in patients with mutations of podocin. (12776285)	Bertelli R.... Ghiggeri G.M.	2003	NPHS2
30	Glomerular endothelial cytotoxicity and dysfunction in nephrosis with focal segmental glomerulosclerosis. (14724375)	Futrakul N.... Futrakul P.	2003	IL10
31	WT-1 and NPHS2 mutation analysis in patients with non-familial steroid-resistant focal-segmental glomerulosclerosis. (12608558)	Lowik M.M.... van den Heuvel L.P.	2003	WT1, NPHS2
32	46,XY phenotypic male with focal segmental glomerulosclerosis caused by the WT1 splice site mutation. (14646409)	Tajima T.... Fujieda K.	2003	WT1
33	Interferon-alpha-induced focal segmental glomerulosclerosis in chronic myelogenous leukemia: a case report and review of the literature. (12796597)	Bremer C.T.... Mudad R.	2003	IFNA1
34	Serial estimates of serum permeability activity and clinical correlates in patients with native kidney focal segmental glomerulosclerosis. (12538746)	Cattran D.... Savin V.J.	2003	ALB, TTR
35	NPHS2 mutations in late-onset focal segmental glomerulosclerosis: R229Q is a common disease-associated allele. (12464671)	Tsukaguchi H.... Pollak M.R.	2002	NPHS2
36	The role of ACE gene polymorphism in rapidity of progression of focal segmental glomerulosclerosis. (12571380)	Dixit M.... Glicklich D.	2002	ACE
37	Significance of early phenotypic change of glomerular podocytes detected by Pax2 in primary focal segmental glomerulosclerosis. (11877566)	Ohtaka A.... Ito S.	2002	PAX2, CHKA
38	Methylenetetrahydrofolate reductase polymorphism in childhood primary focal segmental glomerulosclerosis. (12218328)	Zou C.... Mayumi M.	2002	MTHFR
39	Proteinuria after injection of human focal segmental glomerulosclerosis factor. (11884932)	Sharma M.... Savin V.J.	2002	ALB
40	Phenotypic change of glomerular podocytes in primary focal segmental glomerulosclerosis: developmental paradigm? (12386275)	Ohtaka A.... Ito S.	2002	PAX2
41	Apolipoproteins prevent glomerular albumin permeability induced in vitro by serum from patients with focal segmental glomerulosclerosis. (11134260)	Candiano G.... Ghiggeri G.M.	2001	ALB
42	Prevalence, genetics, and clinical features of patients carrying podocin mutations in steroid-resistant nonfamilial focal segmental glomerulosclerosis. (11729243)	Caridi G.... Ghiggeri G.M.	2001	NPHS2
43	WT1 splice-site mutations are rarely associated with primary steroid-resistant focal and segmental glomerulosclerosis. (10792605)	Denamur E.... Loirat C.	2000	WT1
44	Congenital focal segmental glomerulosclerosis associated with beta4 integrin mutation and epidermolysis bullosa. (10873890)	Kambham N.... D'Agati V.D.	2000	ITGB4
45	The dysregulated podocyte phenotype: a novel concept in the pathogenesis of collapsing idiopathic focal segmental glomerulosclerosis and HIV-associated nephropathy. (9890309)	Barisoni L.... D'Agati V.	1999	SYNPO
46	Circulating factor in patients with recurrent focal segmental glomerulosclerosis postrenal transplantation inhibits expression of inducible nitric oxide synthase and nitric oxide production by cultured rat mesangial cells. (10198566)	Trachtman H.... Savin V.	1999	NOS2
47	A locus for inherited focal segmental glomerulosclerosis maps to chromosome 19q13. (9461087)	Mathis B.J.... Pollak M.R.	1998	ACTN4
48	Altered expression of fibrogenic growth factors in IgA nephropathy and focal and segmental glomerulosclerosis. (8995734)	Stein-Oakley A.N.... Thomsom N.M.	1997	CD79A
49	A randomized double-blind placebo-controlled trial of cyclosporine in steroid-resistant idiopathic focal segmental glomerulosclerosis in children. (8808110)	Lieberman K.V.... Tejani A.	1996	ALB
50	Circulating factor associated with increased glomerular permeability to albumin in recurrent focal segmental glomerulosclerosis. (8596570)	Savin V.J.... Vincenti F.	1996	ALB

Genes related to focal segmental glomerulosclerosis according to GeneCards:

(show top 50)    (show all 68)

id	Symbol	Description	Score	GeneCards Section Context
1	ACTN4	actinin, alpha 4	11.1	Publications, Aliases & Descriptions, Summaries
2	FSGS2	focal segmental glomerulosclerosis 2	11.1	Aliases & Descriptions, Publications
3	INF2	inverted formin, FH2 and WH2 domain containing	11.1	Publications, Summaries
4	TRPC6	transient receptor potential cation channel, subfamily C, member 6	11.1	Publications, Summaries
5	MYO1E	myosin IE	11.1	Summaries, Publications
6	PLCE1	phospholipase C, epsilon 1	11.0	Summaries
7	NPHS2	nephrosis 2, idiopathic, steroid-resistant (podocin)	11.0	Publications
8	WT1-AS	WT1 antisense RNA	11.0	Publications
9	SYNPO	synaptopodin	11.0	Publications
10	LAMB2	laminin, beta 2 (laminin S)	11.0	Publications
11	NPHS1	nephrosis 1, congenital, Finnish type (nephrin)	11.0	Publications
12	CD2AP	CD2-associated protein	11.0	Publications
13	WT1	Wilms tumor 1	11.0	Publications
14	GPX3	glutathione peroxidase 3 (plasma)	11.0	Publications
15	TFAM	transcription factor A, mitochondrial	11.0	Publications
16	COL4A3	collagen, type IV, alpha 3 (Goodpasture antigen)	11.0	Publications
17	ZMPSTE24	zinc metallopeptidase STE24 homolog (S. cerevisiae)	11.0	Publications
18	CDKN1C	cyclin-dependent kinase inhibitor 1C (p57, Kip2)	11.0	Publications
19	PAX2	paired box 2	11.0	Publications
20	ITGA3	integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)	11.0	Publications
21	NRF1	nuclear respiratory factor 1	11.0	Publications
22	NPHP4	nephronophthisis 4	11.0	Publications
23	ITGB4	integrin, beta 4	11.0	Publications
24	PTPRU	protein tyrosine phosphatase, receptor type, U	11.0	Publications
25	SLC12A1	solute carrier family 12 (sodium/potassium/chloride transporters), member 1	11.0	Publications
26	PTPRO	protein tyrosine phosphatase, receptor type, O	11.0	Publications
27	CABIN1	calcineurin binding protein 1	11.0	Publications
28	CHKA	choline kinase alpha	11.0	Publications
29	COG2	component of oligomeric golgi complex 2	11.0	Publications
30	ENPEP	glutamyl aminopeptidase (aminopeptidase A)	11.0	Publications
31	COL4A4	collagen, type IV, alpha 4	11.0	Publications
32	GNE	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	11.0	Publications
33	SMAD3	SMAD family member 3	11.0	Publications
34	THBS1	thrombospondin 1	11.0	Publications
35	SMAD2	SMAD family member 2	11.0	Publications
36	THBD	thrombomodulin	11.0	Publications
37	PON1	paraoxonase 1	11.0	Publications
38	TTR	transthyretin	11.0	Publications
39	MYH9	myosin, heavy chain 9, non-muscle	11.0	Publications
40	AGT	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	11.0	Publications
41	IGFBP1	insulin-like growth factor binding protein 1	11.0	Publications
42	FMN1	formin 1	11.0	Publications
43	ITGB1	integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)	11.0	Publications
44	LMNA	lamin A/C	11.0	Publications
45	ALB	albumin	11.0	Publications
46	MMP14	matrix metallopeptidase 14 (membrane-inserted)	11.0	Publications
47	TF	transferrin	11.0	Publications
48	EDN1	endothelin 1	11.0	Publications
49	TGFB1	transforming growth factor, beta 1	11.0	Publications
50	ARHGAP24	Rho GTPase activating protein 24	11.0	Publications

Pathways related to focal segmental glomerulosclerosis according to GeneDecks:

(show top 50)    (show all 79)

id	Pathway	Score	Top Affiliating Genes
1	ACE Inhibitor Pathway, Pharmacodynamics34	10.5	AGTR1
2	Cell adhesion_Endothelial cell contacts by non-junctional mechanisms41	10.4	ITGB1, ITGB4, COL4A3, COL4A4, ACTN4, ITGA3
3	Cell adhesion Endothelial cell contacts by non-junctional mechanisms10	10.4	ACTN4, COL4A4, COL4A3, ITGB4, ITGB1, ITGA3
4	ECM-receptor interaction20	10.2	THBS1, COL4A4, ITGB4, ITGB1, ITGA3, LAMB2
5	Ras Pathway36	10.2	ITGA3, ITGB1, ITGB4, PLCE1
6	Cell adhesion_Integrin-mediated cell adhesion and migration41	10.2	MYH9, ACTN4, COL4A4, COL4A3, ITGB1, ITGA3
7	PTEN Pathway36	10.2	COL4A4, COL4A3, IL2RA, ITGB4, ITGA3, LAMB2
8	Cell adhesion Integrin-mediated cell adhesion and migration10	10.2	MYH9, ACTN4, COL4A4, COL4A3, ITGB1, ITGA3
9	Actin-Based Motility by Rho Family GTPases36	10.2	ITGB4, IGF1
10	Epithelial Adherens Junctions36	10.2	MYH9, TFAM, ACTN4, PTPRO, PTPRU, BMP6
11	Inhibition of Angiogenesis by TSP136	10.2	THBS1, COL4A4, COL4A3, FYN, LAMB2
12	Renin-angiotensin system20	10.2	AGTR1, AGT, ACE, ENPEP
13	Glioma Invasiveness36	10.1	ITGB4, ITGB1, ITGA3, BMP6
14	Focal adhesion20	10.0	THBS1, ACTN4, COL4A4, ITGB4, ITGB1, ITGA3
15	Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics34	10.0	TGFB1, AGTR1, AGT, ACE
16	Pathways in cancer20	10.0	TGFB1, COL4A4, NOS2, SMAD2, ITGB1, LAMB2
17	FAK1 Signaling36	9.8	COL4A4, COL4A3, ITGB4, ITGB1, ITGA3, FYN
18	Amoebiasis20	9.6	TGFB1, ACTN4, COL4A4, NOS2, IL6, LAMB2
19	Cell adhesion ECM remodeling10	9.5	COL4A4, COL4A3, IGF1, MMP14, ITGB1
20	ILK Signaling36	9.5	VIM, MYH9, TFAM, ACTN4, COL4A4, COL4A3
21	IL-2 Signaling and its Primary Biological Effects in Different Immune Cell Types37	9.4	TGFB1, TNF, IL2RA, IL10
22	Epithelial Tight Junctions36	9.4	ITGA3, ITGB1, ITGB4, TNF, ACTN4, TGFB1
23	Dilated cardiomyopathy20	9.4	TGFB1, TNF, IGF1, ITGB4, ITGB1, ITGA3
24	Cell adhesion_ECM remodeling41	9.2	COL4A3, IGF1, MMP14, ITGB1, COL4A4
25	Molecular Mechanisms of Cancer36	9.2	TGFB1, COL4A4, IL6, ITGB4, ITGB1, FYN
26	TGF-beta signaling pathway20	8.9	TGFB1, THBS1, SMAD3, SMAD2, TNF, IFNG
27	PPAR Pathway36	8.8	TNF, IGF1, IL6, IL2RA, ITGB4, ITGB1
28	ERK Signaling36	8.8	TGFB1, COL4A4, COL4A3, IL6, IL10, ITGB4
29	Rap1 Pathway36	8.7	TGFB1, PLCE1, IGF1, IL6, ITGB4, ITGB1
30	Rho Family GTPases36	8.7	TGFB1, COL4A4, COL4A3, IGF1, IL10, ITGB4
31	Rac1 Pathway36	8.7	ITGA3, ITGB1, ITGB4, IL2RA, IL6, IGF1
32	Akt Signaling36	8.6	TNF, IL6, IL2RA, IL10, ITGB4
33	Hypertrophic cardiomyopathy (HCM)20	8.6	TGFB1, ACE, TNF, IGF1, IL6, ITGB4
34	Leishmaniasis20	8.5	TGFB1, NOS2, TNF, IFNG, IL10, ITGB1
35	Toxoplasmosis20	8.4	TGFB1, NOS2, TNF, IFNG, IL10, ITGB1
36	Renin-Angiotensin Pathway36	8.3	TGFB1, AGTR1, AGT, ACE, IGF1, IL6
37	Malaria20	8.2	TGFB1, THBS1, TNF, IFNG, IL6, IL10
38	Phospholipase-C Pathway36	8.1	IL6, IGF1, PLCE1, COL4A3, COL4A4, TGFB1
39	MAPK Signaling36	8.1	TNF, PLCE1, COL4A3, COL4A4, TGFB1, TFAM
40	Transcription_Role of VDR in regulation of genes involved in osteoporosis41	7.9	SMAD3, TNF, IFNG, IGF1, APOE, IL6
41	Transcription Role of VDR in regulation of genes involved in osteoporosis10	7.9	SMAD3, TNF, IFNG, IGF1, APOE, IL6
42	PAK Pathway36	7.9	MYH9, TGFB1, MYO1E, BMP6, IL10, IL2RA
43	Cytokine Network36	7.8	TNF, IFNG, IFNA2, IFNA1, IL6, IL10
44	Tec Kinases Signaling36	7.8	TGFB1, TNF, IGF1, IL6, IL2RA, IL10
45	Antioxidant Action of Vitamin-C36	7.7	MYH9, TGFB1, PLCE1, TNF, IGF1, IL6
46	Chagas disease (American trypanosomiasis)20	7.6	TGFB1, ACE, NOS2, SMAD3, SMAD2, TNF
47	Tuberculosis20	7.3	TGFB1, NOS2, TNF, IFNG, IFNA2, IFNA1
48	Cytokine-cytokine receptor interaction20	6.8	TGFB1, IL10, IL2RA, IL6, IFNA1, IFNA2
49	JAK-STAT Pathway36	6.7	TGFB1, AGTR1, AGT, IFNG, IFNA2, IFNA1
50	African trypanosomiasis20	INF	TNF, IFNG, , IL6, IL10

Compounds related to focal segmental glomerulosclerosis according to GeneDecks:

(show top 50)    (show all 257)

id	Compound	Score	Top Affiliating Genes
1	glucose32	10.4	NPHS1, PTPRU, IFNA2
2	hyaluronic acid32 18	10.9	BMP6, WT1, TTR, VIM, THBD, THBS1
3	polyethylene glycol32	9.6	APOE, IGFBP1, IFNA2, THBD, PON1
4	ascorbic acid32 18	10.3	GPX3, TF, TTR, IFNA2, IGFBP3, IL2RA
5	rapamycin32 42	10.3	AGT, VIM, IFNG
6	calcitriol32 42 9 18 9	13.1	THBS1, BMP6, ITGB1, MMP14, IL2RA, IGFBP1
7	heparin32 9 18 9	11.9	AGT, ALB, IGFBP1, GPX3, AGTR1, CD79A
8	procollagen32	8.7	BMP6, ZMPSTE24, TGFB1, THBS1, SMAD3, SMAD2
9	histamine32 18	9.6	CD79A, ALB, EDN1, THBD, IL2RA, IFNA2
10	arginine32	8.6	AGTR1, TTR, NPHS1, PON1, AGT, EDN1
11	8-isoprostane32	8.4	IL6, GPX3, TNF, EDN1, IL10, TF
12	fibrinogen32	8.3	ALB, THBD, IGFBP1, AGT, THBS1, PON1
13	tgf beta132	7.9	BMP6, MMP14, IL10, IL6, IGFBP3, TNF
14	losartan32 34 9 9	10.9	BMP6, APOE, ENPEP, IGFBP3, IGF1, ALB
15	alpha tocopherol32	7.9	APOE, TTR, ALB, IFNA2, IGF1, IGFBP3
16	mycophenolate mofetil32 9 9	9.9	CABIN1, ALB, IFNG, IFNA1, IL2RA, IL10
17	betacarotene32	7.9	CHKA, MTHFR, CD79A, IL10, IL2RA, APOE
18	aspirin32 34 18	9.8	CD79A, PON1, COG2, BMP6, TGFB1, THBD
19	rosiglitazone32 9 18 9	10.8	PON1, IL6, TGFB1, THBS1, COG2, LMNA
20	azathioprine32 34 9 9	10.8	IFNA2, IL2RA, VIM, MTHFR, CD79A, IL10
21	steroid32	7.6	IL2RA, ITGB1, CD2AP, CD79A, FYN, AGT
22	cysteine32	7.6	ITGB1, MTHFR, THBD, THBS1, CD79A, AGTR1
23	prostacyclin32	7.5	TNF, THBD, BMP6, IL10, APOE, THBS1
24	chloroquine32 34 9 9	10.5	IL2RA, IL10, CD79A, BMP6, APOE, IGFBP3
25	estrogen32	7.5	COG2, CHKA, MTHFR, MMP14, APOE, IGFBP1
26	paraffin32	7.5	APOE, MMP14, VIM, CD79A, TF, TGFB1
27	vegf32	7.5	IGFBP3, IGF1, SMAD2, SMAD3, COL4A3, WT1
28	atorvastatin32 34 9 18 9	11.4	COG2, BMP6, CHKA, IL10, IL2RA, IL6
29	lactate32	7.3	CD79A, THBD, TGFB1, TF, CHKA, BMP6
30	thyroxine32 18	8.2	PON1, TF, COG2, CHKA, CD79A, IL10
31	sb 20358032 42	8.1	VIM, BMP6, ITGB1, IL6, IGF1, IFNG
32	cyclosporin a32 42	8.0	TF, NPHS2, TGFB1, FYN, ITGB1, IL10
33	creatinine32	7.0	LMNA, BMP6, TF, SYNPO, PON1, NPHS1
34	neopterin32	6.9	TNF, IFNG, IFNA2, IFNA1, IL6, IL10
35	simvastatin32 34 42 9 18 9	11.9	BMP6, CHKA, IL10, IL6, APOE, COG2
36	alanine32	6.6	ENPEP, GPX3, IGFBP1, IGFBP3, IFNA1, IFNA2
37	prednisolone32 9 9	8.1	TF, THBD, TNF, BMP6, CD79A, IL10
38	genistein32 9 18 9	9.1	MMP14, IL2RA, IL6, IGFBP1, IGF1, IFNG
39	indomethacin32 9 9	8.1	NPHS1, TGFB1, AGT, EDN1, VIM, BMP6
40	tyrosine32	6.0	PTPRU, MYH9, NPHS2, THBS1, THBD, NPHS1
41	actinomycin d32	5.9	TGFB1, THBD, AGT, MMP14, IL6, AGTR1
42	vitamin d32	5.9	MTHFR, CD79A, IL10, IL2RA, IL6, APOE
43	nitric oxide32 9 18 9	8.7	ITGB4, IL10, IL6, GPX3, IGFBP1, IFNG
44	serine32	5.3	LMNA, BMP6, ZMPSTE24, PAX2, CHKA, MTHFR
45	retinoic acid32 42 18	6.9	LMNA, WT1, TTR, THBD, THBS1, TGFB1
46	thymidine32 18	5.8	SMAD2, SMAD3, WT1, EDN1, AGT, THBS1
47	dexamethasone32 42 34 9 9	8.4	VIM, BMP6, CHKA, CD79A, ITGB1, MMP14
48	cycloheximide32	4.4	VIM, AGTR1, THBD, THBS1, TGFB1, EDN1
49	cholesterol32 9 18 9	INF	COG2, LMNA, ZMPSTE24, CHKA, MTHFR, FYN
50	lipid32	INF	IL6, IFNA2, ALB, TRPC6, TNF, NRF1

Cellular components related to focal segmental glomerulosclerosis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	slit diaphragm	GO:036057	10.3	TRPC6, NPHS1, NPHS2
2	integrin complex	GO:008305	9.7	MYH9, ITGB4, ITGB1, ITGA3
3	platelet alpha granule lumen	GO:031093	9.6	TGFB1, THBS1, ACTN4, ALB, IGF1
4	external side of plasma membrane	GO:009897	8.5	THBS1, ACE, TNF, IFNG, ENPEP, ITGB1
5	plasma membrane	GO:005886	6.4	PTPRU, PTPRO, SMAD3, PLCE1, ACE, AGTR1
6	extracellular region	GO:005576	5.9	EDN1, ACTN4, AGT, TTR, THBS1, TGFB1
7	extracellular space	GO:005615	INF	BMP6, TNF, EDN1, ACE, AGT, TTR

Biological processes related to focal segmental glomerulosclerosis according to GeneDecks:

(show all 34)

id	Name	GO ID	Score	Top Affiliating Genes
1	SMAD protein complex assembly	GO:007183	10.6	SMAD2, SMAD3
2	glomerulus development	GO:032835	10.6	WT1, PLCE1, PTPRO, ENPEP
3	glomerular basement membrane development	GO:032836	10.6	MYO1E, COL4A3, COL4A4, WT1, NPHS1
4	regulation of binding	GO:051098	10.4	TGFB1, SMAD3, SMAD2
5	regulation of systemic arterial blood pressure by renin-angiotensin	GO:003081	10.3	ENPEP, ACE, AGTR1
6	ureteric bud development	GO:001657	10.3	TGFB1, WT1, SMAD3, SMAD2
7	positive regulation of cellular protein metabolic process	GO:032270	10.2	AGT, AGTR1, TGFB1
8	regulation of vasoconstriction	GO:019229	10.1	AGTR1, AGT, ACE, EDN1
9	regulation of transforming growth factor beta receptor signaling pathway	GO:017015	10.1	SMAD2, SMAD3, TGFB1
10	positive regulation of cardiac muscle hypertrophy	GO:010613	10.0	IGF1, EDN1, AGT
11	positive regulation of cholesterol esterification	GO:010873	9.9	AGTR1, AGT, APOE
12	kidney development	GO:001822	9.9	AGTR1, AGT, ACE, WT1, BMP6
13	positive regulation of cell migration	GO:030335	9.9	TGFB1, THBS1, EDN1, SMAD3, MMP14, ITGB1
14	axon guidance	GO:007411	9.9	MYH9, COL4A4, COL4A3, PTPRO, TRPC6, ITGB1
15	calcium-mediated signaling	GO:019722	9.8	AGTR1, EDN1, PLCE1, TNF
16	negative regulation of blood coagulation	GO:030195	9.8	APOE, EDN1, THBD
17	negative regulation of blood vessel endothelial cell migration	GO:043537	9.8	TGFB1, THBS1, APOE
18	platelet degranulation	GO:002576	9.7	TF, TGFB1, THBS1, ACTN4, ALB, IGF1
19	positive regulation of epithelial cell proliferation	GO:050679	9.6	BMP6, PAX2, IGF1, TGFB1
20	response to hypoxia	GO:001666	9.5	TGFB1, THBS1, ACTN4, EDN1, NOS2, SMAD3
21	leukocyte migration	GO:050900	9.4	MYH9, THBD, ITGB1, ITGA3, FYN
22	positive regulation of MAPK cascade	GO:043410	9.1	ITGB1, IL6, IGFBP3, IGF1, AGT
23	positive regulation of smooth muscle cell proliferation	GO:048661	9.0	EDN1, TNF, IGF1, IL6
24	induction of apoptosis	GO:006917	9.0	TGFB1, THBS1, AGT, WT1, COL4A3, SMAD3
25	cell surface receptor signaling pathway	GO:007166	9.0	EDN1, COL4A3, CABIN1, IFNG, IFNA2, IL2RA
26	negative regulation of apoptotic process	GO:043066	8.9	THBS1, WT1, SMAD3, TNF, ALB, IL6
27	positive regulation of membrane protein ectodomain proteolysis	GO:051044	8.9	APOE, IFNG, TNF
28	platelet activation	GO:030168	8.8	TF, TGFB1, THBS1, ACTN4, TRPC6, ALB
29	negative regulation of transcription from RNA polymerase II promoter	GO:000122	8.7	TGFB1, EDN1, WT1, SMAD3, SMAD2, TNF
30	negative regulation of growth of symbiont in host	GO:044130	8.6	IL10, IFNG, TNF
31	blood coagulation	GO:007596	8.5	ACTN4, THBD, THBS1, TGFB1, TF, NOS2
32	negative regulation of cell proliferation	GO:008285	8.2	SMAD2, COL4A3, WT1, AGT, TGFB1, PTPRU
33	response to drug	GO:042493	8.2	TGFB1, THBS1, EDN1, TNF, IFNG, GPX3
34	positive regulation of transcription, DNA-dependent	GO:045893	8.0	SMAD3, WT1, AGT, TGFB1, TFAM, SMAD2

Molecular functions related to focal segmental glomerulosclerosis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	integrin binding	GO:005178	9.6	THBS1, ACTN4, IGF1, ITGB1, LAMB2
2	growth factor activity	GO:008083	8.3	BMP6, IL10, IL6, IGF1, AGT, TGFB1
3	cytokine activity	GO:005125	7.1	EDN1, TNF, IFNG, IFNA2, IL6, IL10
4	protein binding	GO:005515	INF	MYH9, ACTN4, ACE, WT1, COL4A3, NOS2