MCID: FLC001
MIFTS: 34

Folic Acid Deficiency Anemia malady

Categories: Immune diseases, Blood diseases, Metabolic diseases

Aliases & Classifications for Folic Acid Deficiency Anemia

Aliases & Descriptions for Folic Acid Deficiency Anemia:

Name: Folic Acid Deficiency Anemia 12 14
Megaloblastic Anemia Due to Folate Deficiency 69
Folate-Deficient Megaloblastic Anaemia 12
Folate Deficiency Anemia 12
Folate-Deficiency Anemia 12

Classifications:



External Ids:

Disease Ontology 12 DOID:14026
ICD10 33 D52 D52.9
ICD9CM 35 281.2
UMLS 69 C0151482

Summaries for Folic Acid Deficiency Anemia

MalaCards based summary : Folic Acid Deficiency Anemia, also known as megaloblastic anemia due to folate deficiency, is related to cerebellar hypoplasia and mental retardation with or without quadrupedal locomotion 1 and ovarian papillary cystadenoma. An important gene associated with Folic Acid Deficiency Anemia is SLC46A1 (Solute Carrier Family 46 Member 1), and among its related pathways/superpathways are Insulin receptor recycling and Folate Metabolism. The drugs Hydroxocobalamin and Iron have been mentioned in the context of this disorder. Related phenotypes are hematopoietic system and homeostasis/metabolism

Related Diseases for Folic Acid Deficiency Anemia

Diseases related to Folic Acid Deficiency Anemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 47)
id Related Disease Score Top Affiliating Genes
1 cerebellar hypoplasia and mental retardation with or without quadrupedal locomotion 1 10.2 EPO THPO
2 ovarian papillary cystadenoma 10.2 EPO THPO
3 basal ganglia cerebrovascular disease 10.1 EPO TFRC
4 von hippel anomaly 10.1 EPO TET2
5 cerebral sarcoidosis 10.1 EPO TF
6 episcleritis periodica fugax 10.1 EPO TF
7 tmem231-related joubert syndrome 10.1 TF TFRC
8 leukemia, acute lymphoblastic 3 10.1 GIF TF
9 neurilemmoma of the pleura 10.1 TF TFRC
10 kaolin pneumoconiosis 10.1 TF TFRC
11 esophageal leukoplakia 10.0 TF TFRC
12 congenital intrinsic factor deficiency 10.0 EPO GIF TF
13 larynx sarcoma 10.0 EPO TF
14 villonodular synovitis 10.0 CRP EPO
15 facial paresis, hereditary congenital, 1 10.0 TF TFRC
16 meningeal melanocytoma 10.0 EPO TF
17 erythrocytosis, somatic 10.0 EPO TET2 THPO
18 neuromyelitis optica 10.0 EPO TET2 THPO
19 tmem216-related meckel syndrome 10.0 EPO TF TFRC
20 post-thrombotic syndrome 10.0 EPO TF TFRC
21 basilar artery insufficiency 10.0 EPO TET2 THPO
22 cat-scratch disease 10.0 EPO TF TFRC
23 thalassemia-beta, dominant inclusion-body 10.0 EPO TF TFRC
24 tracheal cancer 10.0 EPO TF TFRC
25 vaginal spindle cell epithelioma 10.0 TF TFRC
26 hemoglobin c disease 10.0 CRP TF
27 harp syndrome 10.0 CRP TF
28 cerebral palsy 10.0 CRP TET2
29 hyperparathyroidism, neonatal 10.0 EPO TET2 THPO
30 neuropathy 10.0 CRP THPO
31 aarskog-scott syndrome 9.9 TET2 TFRC
32 blood coagulation disease 9.9 EPO THPO
33 spastic entropion 9.9 CRP TF
34 granulomatous hepatitis 9.9 CRP EPO THPO
35 retinal arterial macroaneurysm with supravalvular pulmonic stenosis 9.9 CRP EPO TF
36 familial nephrotic syndrome 9.8 CRP EPO TF
37 bile duct mucoepidermoid carcinoma 9.8 CRP EPO TF
38 intestinal impaction 9.8 EPO TET2 TFRC THPO
39 calcinosis 9.8 CRP EPO TF
40 chronic myocardial ischemia 9.8 CRP EPO TF
41 leukemia, acute myeloid 9.8 EPO TET2 TFRC THPO
42 deficiency anemia 9.8
43 central nervous system leiomyoma 9.7 CRP EPO GIF TF
44 membranoproliferative glomerulonephritis 9.7 CRP EPO TF THPO
45 blind hypotensive eye 9.5 CRP EPO TF TFRC THPO
46 neuronal ceroid-lipofuscinoses 9.5 CRP EPO TF TFRC THPO
47 poems syndrome 8.8 CRP EPO GIF MME SLC46A1 TET2

Comorbidity relations with Folic Acid Deficiency Anemia via Phenotypic Disease Network (PDN):


Active Peptic Ulcer Disease Acute Cystitis
Alzheimer Disease Decubitus Ulcer
Deficiency Anemia Heart Disease
Iron Deficiency Anemia Protein-Energy Malnutrition
Schizophreniform Disorder

Graphical network of the top 20 diseases related to Folic Acid Deficiency Anemia:



Diseases related to Folic Acid Deficiency Anemia

Symptoms & Phenotypes for Folic Acid Deficiency Anemia

MGI Mouse Phenotypes related to Folic Acid Deficiency Anemia:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.63 EPO SLC46A1 TET2 TF TFRC THPO
2 homeostasis/metabolism MP:0005376 9.5 CRP EPO MME SLC46A1 TF TFRC
3 immune system MP:0005387 9.17 TET2 TFRC THPO CRP EPO MME

Drugs & Therapeutics for Folic Acid Deficiency Anemia

Drugs for Folic Acid Deficiency Anemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 160)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hydroxocobalamin Approved Phase 4,Phase 2,Phase 3 13422-51-0 11953898 5460373 44475014
2
Iron Approved Phase 4,Phase 3,Phase 2,Phase 1 7439-89-6 23925
3
Copper Approved Phase 4,Phase 3,Phase 2 15158-11-9, 7440-50-8 27099
4
Selenium Approved, Vet_approved Phase 4,Phase 3 7782-49-2
5
Zinc Approved Phase 4,Phase 3 7440-66-6 32051 23994
6
Sulfamethoxazole Approved Phase 4,Phase 2 723-46-6 5329
7
Trimethoprim Approved, Vet_approved Phase 4,Phase 2 738-70-5 5578
8
Dapsone Approved, Investigational Phase 4,Phase 3 80-08-0 2955
9
Abacavir Approved, Investigational Phase 4 136470-78-5 65140 441300
10
Efavirenz Approved, Investigational Phase 4 154598-52-4 64139
11
Lamivudine Approved, Investigational Phase 4 134678-17-4 60825
12
Nevirapine Approved Phase 4,Phase 2 129618-40-2 4463
13
Zidovudine Approved Phase 4 30516-87-1 35370
14
Pyrimethamine Approved, Vet_approved Phase 4,Phase 3 58-14-0 4993
15
Sulfadoxine Approved Phase 4,Phase 3 2447-57-6 17134
16
Cyanocobalamin Approved, Nutraceutical Phase 4,Phase 2,Phase 3 68-19-9 44176380
17
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 59-30-3 6037
18
leucovorin Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1 58-05-9 54575, 6560146 143
19
Niacin Approved, Investigational, Nutraceutical Phase 4,Phase 3,Phase 2 59-67-6 938
20
Nicotinamide Approved, Nutraceutical Phase 4,Phase 3,Phase 2 98-92-0 936
21
Pyridoxal Approved, Nutraceutical Phase 4,Phase 3,Phase 2 66-72-8 1050
22
Pyridoxine Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2 65-23-6 1054
23
Riboflavin Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2 83-88-5 493570
24
Thiamine Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2 59-43-8 1130
25
Vitamin A Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2 11103-57-4, 68-26-8 445354
26
Vitamin C Approved, Nutraceutical Phase 4,Phase 3,Phase 2 50-81-7 5785 54670067
27
Vitamin E Approved, Nutraceutical, Vet_approved Phase 4,Phase 3 59-02-9 14985
28
Cholecalciferol Approved, Nutraceutical Phase 4 67-97-0 6221 10883523 5280795
29 Hematinics Phase 4,Phase 3,Phase 2,Phase 1
30 Micronutrients Phase 4,Phase 3,Phase 2,Phase 1
31 Trace Elements Phase 4,Phase 3,Phase 2,Phase 1
32 Vitamin B 12 Phase 4,Phase 2,Phase 3
33 Vitamin B Complex Phase 4,Phase 3,Phase 2,Phase 1
34 Vitamins Phase 4,Phase 3,Phase 2,Phase 1
35 cadexomer iodine Phase 4,Phase 3,Phase 2
36
Iodine Phase 4,Phase 3,Phase 2 7553-56-2 807
37 Nicotinic Acids Phase 4,Phase 3,Phase 2
38 Retinol palmitate Phase 4,Phase 3,Phase 2
39 Tocopherols Phase 4,Phase 3
40 Tocotrienols Phase 4,Phase 3
41 Vitamin B 6 Phase 4,Phase 3,Phase 2
42 vitamin d Phase 4,Phase 3,Phase 2
43 Ferrous fumarate Phase 4,Phase 3,Phase 2
44 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1
45 Anti-Infective Agents, Local Phase 4
46 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2
47 Antimalarials Phase 4,Phase 3,Phase 2
48 Antiparasitic Agents Phase 4,Phase 3,Phase 2
49 Antiprotozoal Agents Phase 4,Phase 3,Phase 2
50 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 2

Interventional clinical trials:

(show top 50) (show all 61)
id Name Status NCT ID Phase
1 How Many Patients Are in Need of Vitamin B12 Injections? Unknown status NCT00326833 Phase 4
2 Prevention of Intrauterine Growth Retardation in Hounde District, Burkina Faso Completed NCT00642408 Phase 4
3 Effectiveness of Selling Micronutrient Sprinkles in Rural Kenya Completed NCT01088958 Phase 4
4 Iodine Status of Preschoolers Given Micronutrient Powder for 6 Months Completed NCT02280330 Phase 4
5 Safety of Cotrimoxazole in HIV- and HAART-exposed Infants Completed NCT01086878 Phase 4
6 Phase IV Study to Gather More Information About the Safety of ACZONE Gel, 5% in Treating Subjects With Acne Who Have G6PD Deficiency Completed NCT00243542 Phase 4
7 Efficacy Study of Different Laboratory Management Strategies and Drug Regimens in HIV-infected Children in Africa Completed NCT02028676 Phase 4
8 Intermittent Preventive Treatment of Malaria in HIV-Seropositive Pregnant Women in Zambia Completed NCT00270530 Phase 4
9 Impact of Preoperative Treatment of Anemia and Iron Deficiency in Cardiac Surgery on Outcome. Recruiting NCT02031289 Phase 4
10 Trial of Captafer® vs. Oral Iron Sulfate in the Treatment of Iron Deficiency Anemia in Patients With IBD Recruiting NCT02774057 Phase 4
11 Efficacy Trial to Examine Efficacy of Multimicronutrient Home Supplementation in Infants Completed NCT00276198 Phase 3
12 Maintenance of Multivitamin Supplements After Sleeve Gastrectomy Completed NCT02620137 Phase 3
13 Sub-clinical Inflammation and Iron Supplementation Completed NCT01198574 Phase 3
14 Vitamin B12 Supplementation During Pregnancy Completed NCT01795131 Phase 2, Phase 3
15 Prevention of Severe Anaemia in Gambian Children Completed NCT00131716 Phase 3
16 Lapdap and Coartemether for Uncomplicated Malaria Completed NCT00118794 Phase 3
17 An Open, Prospective, Multicenter Study of Trimetrexate With Leucovorin Rescue for AIDS Patients With Pneumocystis Carinii Pneumonia (PCP) and Serious Intolerance to Approved Therapies Completed NCT00000714 Phase 3
18 Vitamin B12 Supplementation During Pregnancy on Cognitive Development Recruiting NCT03071666 Phase 2, Phase 3
19 IV Ferric Carboxymaltose Compared With Oral Iron in the Treatment of Iron Deficiency Anemia at Delivery in Tanzania Active, not recruiting NCT02541708 Phase 3
20 Impact of Pre-pregnancy Micronutrient Supplementation on Maternal and Child Outcomes Active, not recruiting NCT01665378 Phase 3
21 Low-dose Iron Supplementation and Markers of Iron Status Among Non-anemic, Iron-deficient Women Active, not recruiting NCT02683369 Phase 2, Phase 3
22 Oral Vitamin B12 Administration for Vitamin B12 Deficiency After Total Gastrectomy Completed NCT00699478 Phase 2
23 Can Recombinant Human Intrinsic Factor Be Used for Evaluation of the Vitamin B12 Absorption? Completed NCT00279552 Phase 2
24 Treosulfan and Fludarabine Phosphate Before Donor Stem Cell Transplant in Treating Patients With Nonmalignant Inherited Disorders Recruiting NCT00919503 Phase 2
25 Fludarabine Phosphate, Melphalan, and Low-Dose Total-Body Irradiation Followed by Donor Peripheral Blood Stem Cell Transplant in Treating Patients With Hematologic Malignancies Active, not recruiting NCT01529827 Phase 2
26 Study to Improve Survival Among HIV-Exposed Infants in Botswana Active, not recruiting NCT01229761 Phase 2
27 NutFish and Nutrient Supplementation in Pregnancy Class to Improve Maternal and Birth Outcomes Not yet recruiting NCT02959125 Phase 2
28 Relative Bioavailability of Iron and Folic Acid in New Test Supplement Completed NCT00789490 Phase 1
29 Cyclophosphamide in Treating Patients Who Are Undergoing a Donor Bone Marrow Transplant for Fanconi's Anemia Completed NCT00317876 Phase 1
30 Iron Supplementation Among Adolescent Girls in India Unknown status NCT00198848
31 Iron and Vitamin Adminstration Prior to Joint Replacement to Prevent Transfusion Unknown status NCT01676740
32 Complications After Bariatric Surgery - a Clinical Trial Unknown status NCT01930838
33 Impact of Iron/Folic Acid vs Folic Acid Supplements During Pregnancy on Maternal and Child Health Completed NCT02221752
34 Treatment and Prevention of Anemia With Ferrous Sulfate Plus Folic Acid in Children in Goiania - Goias, Brazil Completed NCT00701246
35 Healthy Infant Development Project Completed NCT00613717
36 Is Iron Deficiency the Cause of Anemia Among Women in Cambodia? Completed NCT02481375
37 Changes in Microbiota and Iron Status After Iron Fortification of Complementary Foods Completed NCT01111864
38 Iron Absorption From a Micronutrient Powder Containing Galacto-oligosaccharides (GOS) Completed NCT02666417
39 Effectiveness of LNS and MNP Supplements to Prevent Malnutrition in Women and Their Children in Bangladesh Completed NCT01715038
40 The Burden of Childhood Anemia in Bangladesh: Does Socioeconomic Status Matter? Completed NCT03126253
41 A Retrospective Analysis of Neevo®/Neevo®DHA Compared to a Standard Prenatal Vitamin in Anemia During Pregnancy Completed NCT01062958
42 Fe Absorption in Mother and Child Pairs From Wheat Fortified With Iron With and Without Phenolic Containing Beverages Completed NCT02437955
43 Cystatin SN Binds to Phytic Acid and Predicts Non-heme Iron Bioavailability Completed NCT03030703
44 Iron and Prebiotics Fortification in Kenyan Infants Completed NCT02118402
45 Malaria and the Safety of Iron Supplements and Iron Fortification Completed NCT01156896
46 Long-term Iron Supplements and Malaria Risk in Early Pregnancy: a Randomized Controlled Trial Completed NCT01210040
47 Absorption of Heme and Non-Heme Iron in Pregnant and Non-pregnant Women and Mechanisms of Fetal Iron Transfer Completed NCT01019096
48 Impact of Vitamin B12 Replacement on Epogen Dosing and Improvement of Quality of Life in Hemodialysis Patients Completed NCT01876732
49 Comparison of Two Pharmacist-led Population Management Approaches to Increase Monitoring of Vitamin B12 and Serum Creatinine Levels for Patients on Metformin Completed NCT02076347
50 Evaluation of Holotranscobalamin as an Indicator of Vitamin B12 Absorption Completed NCT00235573

Search NIH Clinical Center for Folic Acid Deficiency Anemia

Genetic Tests for Folic Acid Deficiency Anemia

Anatomical Context for Folic Acid Deficiency Anemia

Publications for Folic Acid Deficiency Anemia

Articles related to Folic Acid Deficiency Anemia:

id Title Authors Year
1
Folic acid deficiency anemia. ( 4905911 )
1970

Variations for Folic Acid Deficiency Anemia

Expression for Folic Acid Deficiency Anemia

Search GEO for disease gene expression data for Folic Acid Deficiency Anemia.

Pathways for Folic Acid Deficiency Anemia

GO Terms for Folic Acid Deficiency Anemia

Cellular components related to Folic Acid Deficiency Anemia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.73 CRP EPO GIF TF TFRC THPO
2 apical plasma membrane GO:0016324 9.54 GIF SLC46A1 TF
3 cell surface GO:0009986 9.46 EPO SLC46A1 TF TFRC
4 extracellular space GO:0005615 9.43 CRP EPO GIF TF TFRC THPO
5 clathrin-coated pit GO:0005905 9.4 TF TFRC
6 clathrin-coated vesicle membrane GO:0030665 9.32 TF TFRC
7 HFE-transferrin receptor complex GO:1990712 8.62 TF TFRC

Biological processes related to Folic Acid Deficiency Anemia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 acute-phase response GO:0006953 9.26 CRP EPO
2 transferrin transport GO:0033572 9.16 TF TFRC
3 myeloid cell differentiation GO:0030099 8.96 TET2 THPO
4 cellular iron ion homeostasis GO:0006879 8.8 SLC46A1 TF TFRC

Molecular functions related to Folic Acid Deficiency Anemia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 ferrous iron binding GO:0008198 8.62 TET2 TF

Sources for Folic Acid Deficiency Anemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....