MCID: FLC001
MIFTS: 30

Folic Acid Deficiency Anemia

Categories: Immune diseases, Blood diseases, Metabolic diseases

Aliases & Classifications for Folic Acid Deficiency Anemia

MalaCards integrated aliases for Folic Acid Deficiency Anemia:

Name: Folic Acid Deficiency Anemia 12 14
Megaloblastic Anemia Due to Folate Deficiency 69
Folate-Deficient Megaloblastic Anaemia 12
Folate Deficiency Anemia 12
Folate-Deficiency Anemia 12

Classifications:



External Ids:

Disease Ontology 12 DOID:14026
ICD10 32 D52 D52.9
ICD9CM 34 281.2
UMLS 69 C0151482

Summaries for Folic Acid Deficiency Anemia

MalaCards based summary : Folic Acid Deficiency Anemia, also known as megaloblastic anemia due to folate deficiency, is related to deficiency anemia and splenic disease. An important gene associated with Folic Acid Deficiency Anemia is SLC46A1 (Solute Carrier Family 46 Member 1), and among its related pathways/superpathways are Insulin receptor recycling and Selenium Micronutrient Network. Related phenotypes are hematopoietic system and homeostasis/metabolism

Related Diseases for Folic Acid Deficiency Anemia

Diseases related to Folic Acid Deficiency Anemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 50)
# Related Disease Score Top Affiliating Genes
1 deficiency anemia 28.3 CRP EPO TF TFRC THPO
2 splenic disease 10.3 EPO THPO
3 hypersplenism 10.2 EPO THPO
4 fetal erythroblastosis 10.2 EPO TFRC
5 chromosome 5q deletion syndrome 10.2 EPO TET2
6 erythrocytosis, familial, 1 10.2 EPO THPO
7 refractory anemia 10.2 EPO TET2
8 pure red-cell aplasia 10.2 EPO TF
9 angiomatous meningioma 10.1 TF TFRC
10 metal metabolism disorder 10.1 TF TFRC
11 siderosis 10.1 TF TFRC
12 pancytopenia 10.1 EPO THPO
13 galactosemia 10.1 GIF TF
14 hemoglobinopathy 10.1 EPO TF
15 angioimmunoblastic t-cell lymphoma 10.0 MME TET2
16 anemia, sideroblastic, 1 10.0 TET2 TFRC
17 congenital hemolytic anemia 10.0 EPO TF
18 vitamin b12 deficiency 10.0 EPO GIF TF
19 miliary tuberculosis 10.0 CRP EPO
20 polycythemia vera 9.9 EPO TET2 THPO
21 hemosiderosis 9.9 EPO TF TFRC
22 iron metabolism disease 9.9 EPO TF TFRC
23 essential thrombocythemia 9.9 EPO TET2 THPO
24 hemoglobin h disease 9.9 EPO TF TFRC
25 microcytic anemia 9.9 EPO TF TFRC
26 myelofibrosis 9.9 EPO TET2 THPO
27 thalassemia 9.9 EPO TF TFRC
28 beta-thalassemia 9.9 EPO TF TFRC
29 melancholia 9.9 CRP TF
30 porphyria cutanea tarda 9.9 TF TFRC
31 cartilage disease 9.9 CRP TET2
32 aplastic anemia 9.9 EPO TET2 THPO
33 perinatal necrotizing enterocolitis 9.8 CRP THPO
34 atransferrinemia 9.8 TET2 TF TFRC
35 dysentery 9.8 CRP TF
36 analbuminemia 9.6 CRP EPO TF
37 end stage renal failure 9.6 CRP EPO TF
38 uremia 9.6 CRP EPO TF
39 urinary system disease 9.6 CRP EPO TF
40 polycythemia 9.6 EPO TET2 TFRC THPO
41 chronic kidney failure 9.6 CRP EPO TF
42 leukemia, acute myeloid 9.6 MME TET2 THPO
43 myelodysplastic syndrome 9.6 EPO TET2 TFRC THPO
44 inherited metabolic disorder 9.5 CRP TF
45 purpura 9.4 CRP THPO
46 nutritional deficiency disease 9.4 CRP EPO GIF TF
47 thrombocytosis 9.3 CRP EPO TET2 THPO
48 malaria 9.2 CRP EPO TF TFRC
49 iron deficiency anemia 9.0 CRP EPO TF TFRC THPO
50 immune system disease 9.0 CRP EPO TF TFRC THPO

Comorbidity relations with Folic Acid Deficiency Anemia via Phenotypic Disease Network (PDN):


Active Peptic Ulcer Disease Acute Cystitis
Alzheimer Disease Decubitus Ulcer
Deficiency Anemia Heart Disease
Iron Deficiency Anemia Protein-Energy Malnutrition
Schizophreniform Disorder

Graphical network of the top 20 diseases related to Folic Acid Deficiency Anemia:



Diseases related to Folic Acid Deficiency Anemia

Symptoms & Phenotypes for Folic Acid Deficiency Anemia

MGI Mouse Phenotypes related to Folic Acid Deficiency Anemia:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.8 GIF SLC46A1 TET2 TF TFRC THPO
2 homeostasis/metabolism MP:0005376 9.76 GIF MME SLC46A1 TF TFRC THPO
3 immune system MP:0005387 9.56 GIF MME SLC46A1 TET2 TFRC THPO
4 liver/biliary system MP:0005370 9.02 EPO GIF MME TET2 TFRC

Drugs & Therapeutics for Folic Acid Deficiency Anemia

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Natural Versus Synthetic Vitamin B Complexes in Human Completed NCT03444155

Search NIH Clinical Center for Folic Acid Deficiency Anemia

Genetic Tests for Folic Acid Deficiency Anemia

Anatomical Context for Folic Acid Deficiency Anemia

Publications for Folic Acid Deficiency Anemia

Articles related to Folic Acid Deficiency Anemia:

# Title Authors Year
1
Folic acid deficiency anemia. ( 4905911 )
1970

Variations for Folic Acid Deficiency Anemia

Expression for Folic Acid Deficiency Anemia

Search GEO for disease gene expression data for Folic Acid Deficiency Anemia.

Pathways for Folic Acid Deficiency Anemia

GO Terms for Folic Acid Deficiency Anemia

Cellular components related to Folic Acid Deficiency Anemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.73 CRP EPO GIF TF TFRC THPO
2 apical plasma membrane GO:0016324 9.54 GIF SLC46A1 TF
3 cell surface GO:0009986 9.46 EPO SLC46A1 TF TFRC
4 extracellular space GO:0005615 9.43 CRP EPO GIF TF TFRC THPO
5 clathrin-coated pit GO:0005905 9.4 TF TFRC
6 clathrin-coated vesicle membrane GO:0030665 9.32 TF TFRC
7 HFE-transferrin receptor complex GO:1990712 8.62 TF TFRC

Biological processes related to Folic Acid Deficiency Anemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 acute-phase response GO:0006953 9.26 CRP EPO
2 transferrin transport GO:0033572 9.16 TF TFRC
3 myeloid cell differentiation GO:0030099 8.96 TET2 THPO
4 cellular iron ion homeostasis GO:0006879 8.8 SLC46A1 TF TFRC

Molecular functions related to Folic Acid Deficiency Anemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ferrous iron binding GO:0008198 8.62 TET2 TF

Sources for Folic Acid Deficiency Anemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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