MCID: FLL031
MIFTS: 39

Follicular Adenoma

Categories: Cancer diseases, Endocrine diseases

Aliases & Classifications for Follicular Adenoma

MalaCards integrated aliases for Follicular Adenoma:

Name: Follicular Adenoma 12 14 69
Follicular Adenoma of the Thyroid Gland 12
Thyroid Gland Follicular Adenoma 69
Thyroid Follicular Adenoma 12
Adenoma Follicular 52

Classifications:



External Ids:

Disease Ontology 12 DOID:6204
MeSH 42 D000236
SNOMED-CT 64 55021007
UMLS 69 C0205647

Summaries for Follicular Adenoma

MalaCards based summary : Follicular Adenoma, also known as follicular adenoma of the thyroid gland, is related to atypical follicular adenoma and oxyphilic adenoma. An important gene associated with Follicular Adenoma is MINPP1 (Multiple Inositol-Polyphosphate Phosphatase 1), and among its related pathways/superpathways are Pathways in cancer and Insulin secretion. The drugs Formaldehyde and Iodine have been mentioned in the context of this disorder. Affiliated tissues include thyroid, bone and breast, and related phenotypes are Increased shRNA abundance and endocrine/exocrine gland

Related Diseases for Follicular Adenoma

Diseases related to Follicular Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 94)
id Related Disease Score Top Affiliating Genes
1 atypical follicular adenoma 12.1
2 oxyphilic adenoma 10.9
3 adenohypophysitis 10.7 TG TPO
4 maxillary sinus adenoid cystic carcinoma 10.7 TG TPO
5 childhood mediastinal neurogenic tumor 10.7 CALCA TG
6 rhabdomyosarcoma, embryonal, 2 10.7 TG TPO
7 corneal ectasia 10.7 CALCA TG
8 cervical endometrial stromal sarcoma 10.6 CALCA TG
9 adenoma 10.6
10 chronic neutrophilic leukemia 10.6 LGALS3 NKX2-1
11 thyroiditis 10.6
12 congenital granular cell tumor 10.6 CALCA TG
13 parietal lobe neoplasm 10.5 CALCA TG
14 mature teratoma 10.5 NKX2-1 TG
15 tick paralysis 10.5 TG TPO
16 bowman's membrane folds or rupture 10.5 KRT19 PTEN
17 chronic frontal sinusitis 10.5 TG TPO
18 hypodermyasis 10.4 CALCA TG
19 fallopian tube leiomyoma 10.4 CALCA NKX2-1 TG
20 hypothyroidism, congenital, nongoitrous 4 10.4 TG TPO
21 periventricular nodular heterotopia 6 10.4 KRT19 LGALS3 PTEN
22 color blindness 10.3 TG TPO
23 leprosy 6 10.3 CALCA KRT19 NKX2-1
24 lung lymphoma 10.3 CALCA TG
25 brown-vialetto-van laere syndrome 10.3 KRT19 NKX2-1 PTEN
26 chronic polyneuropathy 10.3 RET TG TSHR
27 brachyolmia 10.3 CALCA NKX2-1 PTEN
28 background diabetic retinopathy 10.2 TG TPO TSHR
29 amelogenesis imperfecta, hypomaturation type, iia6 10.2 TG TPO TSHR
30 cerebral lipidosis 10.2 TG TPO TSHR
31 conjunctival deposit 10.2 TG TPO TSHR
32 lung occult large cell carcinoma 10.2 TG TPO TSHR
33 combined cellular and humoral immune defects with granulomas 10.2 TG TPO TSHR
34 cd3zeta deficiency 10.2 TG TPO TSHR
35 sporadic hemiplegic migraine 10.2 CALCA CDKN1B RET
36 hyperparathyroidism, familial primary 10.2 CALCA CDKN1B RET
37 lymphoma 10.2 TG TPO TSHR
38 skin meningioma 10.2 TG TPO TSHR
39 central hypoventilation syndrome, congenital 10.2 CALCA RET
40 papillary carcinoma 10.2
41 medullary thyroid carcinoma, familial 10.2 CALCA NKX2-1 RET TG
42 subserous uterine fibroid 10.1 CALCA CDKN1B RET
43 pseudohypoparathyroidism 10.1 TG TPO TSHR
44 pulmonary neuroendocrine tumor 10.1 PAX8 TG
45 pulsating exophthalmos 10.1 TG TPO TSHR
46 viral encephalitis 10.1 CALCA PTEN RET TG
47 demyelinating polyneuropathy 10.0 KRT19 LGALS3 NKX2-1 RET TG
48 kidney disease 10.0 NKX2-1 RET TG TSHR
49 parachordoma 10.0 NKX2-1 RET TG TSHR
50 invasive malignant thymoma 9.9 PAX8 PTEN

Graphical network of the top 20 diseases related to Follicular Adenoma:



Diseases related to Follicular Adenoma

Symptoms & Phenotypes for Follicular Adenoma

GenomeRNAi Phenotypes related to Follicular Adenoma according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance GR00327-A 8.92 CALCA CDKN1B LGALS3 MCM2

MGI Mouse Phenotypes related to Follicular Adenoma:

44 (show all 13)
id Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 10.27 DPP4 KRT19 MCM2 NKX2-1 PAX8 PTEN
2 growth/size/body region MP:0005378 10.26 TG TP53BP1 TPO TSHR CDKN1B DPP4
3 cellular MP:0005384 10.18 CDKN1B KRT19 LGALS3 MCM2 NKX2-1 PAX8
4 homeostasis/metabolism MP:0005376 10.17 CDKN1B DPP4 LGALS3 NKX2-1 PAX8 PTEN
5 mortality/aging MP:0010768 10.14 CDKN1B KRT19 LGALS3 MCM2 NKX2-1 PAX8
6 hematopoietic system MP:0005397 10.11 CDKN1B LGALS3 MCM2 PTEN RET TG
7 digestive/alimentary MP:0005381 10.05 CDKN1B KRT19 LGALS3 MCM2 NKX2-1 PTEN
8 neoplasm MP:0002006 10.02 CDKN1B KRT19 LGALS3 MCM2 NKX2-1 PTEN
9 nervous system MP:0003631 10.02 CDKN1B KRT19 LGALS3 MCM2 NKX2-1 PAX8
10 reproductive system MP:0005389 9.81 CDKN1B KRT19 LGALS3 NKX2-1 PAX8 PTEN
11 normal MP:0002873 9.8 PTEN RET KRT19 MCM2 MINPP1 NKX2-1
12 respiratory system MP:0005388 9.43 CDKN1B LGALS3 MCM2 NKX2-1 PTEN RET
13 skeleton MP:0005390 9.23 CDKN1B KRT19 LGALS3 NKX2-1 PAX8 PTEN

Drugs & Therapeutics for Follicular Adenoma

Drugs for Follicular Adenoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Formaldehyde Approved, Vet_approved 50-00-0 712
2
Iodine Investigational 7553-56-2 807
3 cadexomer iodine

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Effect of Pasireotide Long Acting Release (LAR) on Gonadotroph Adenomas Terminated NCT00929669 Phase 2 pasireotide LAR
2 Evaluation of a New CZT System Unknown status NCT01084356
3 Biomarkers to Distinguish Benign From Malignant Thyroid Neoplasm Completed NCT01433809
4 Molecular Markers in Thyroid Cancer Completed NCT00598364
5 Expression of NIS Protein and mRNA in Thyroid Tumors Completed NCT00459498
6 Alterations in Muscle's Functional Characteristics After Parathyroid Surgery for Primary Hyperparathyroidism. Recruiting NCT03091140
7 Expression of Protein Convertases in Thyroid Nodules Enrolling by invitation NCT03160482
8 ctDNA in Patients With Thyroid Nodules Terminated NCT02778412

Search NIH Clinical Center for Follicular Adenoma

Genetic Tests for Follicular Adenoma

Anatomical Context for Follicular Adenoma

MalaCards organs/tissues related to Follicular Adenoma:

39
Thyroid, Bone, Breast, Lung, Colon

Publications for Follicular Adenoma

Articles related to Follicular Adenoma:

(show top 50) (show all 122)
id Title Authors Year
1
A rare presentation: A case report of osseous metaplasia and mature bone formation in a follicular adenoma of the thyroid. ( 28648877 )
2017
2
Tumor-to-tumor metastasis: Small cell carcinoma lung metastasising into a follicular adenoma of the thyroid. ( 28195115 )
2017
3
Follicular adenoma in ectopic thyroid. A case-report. ( 28946030 )
2017
4
Incidental ectopic thyroid follicular adenoma on myocardial perfusion imaging. ( 26122882 )
2016
5
Can Nodular Hyperplasia of the Thyroid Gland be Differentiated From Follicular Adenoma and Follicular Carcinoma by Ultrasonography? ( 27870787 )
2016
6
Association between p53-binding protein 1 expression and genomic instability in oncocytic follicular adenoma of the thyroid. ( 26935218 )
2016
7
Papillary Thyroid Carcinoma Arising Within a Follicular Adenoma: A Case Report, Ultrasound Features, and Considerations. ( 27110655 )
2016
8
Expression of ARE-binding proteins AUF1 and HuR in follicular adenoma and carcinoma of thyroid gland. ( 26925783 )
2016
9
Thyroid follicular adenoma with numerous intracytoplasmic lumina mimicking yellow bodies: a case report. ( 27146719 )
2016
10
Mutational burdens and evolutionary ages of thyroid follicular adenoma are comparable to those of follicular carcinoma. ( 27626165 )
2016
11
Comparison of microarray expression profiles between follicular variant of papillary thyroid carcinomas and follicular adenomas of the thyroid. ( 25923053 )
2015
12
Risk of thyroid follicular adenoma among children and adolescents in Belarus exposed to iodine-131 after the Chornobyl accident. ( 26443421 )
2015
13
Appearance of HA1rthle cell carcinoma soon after surgical extirpation of HA1rthle cell adenoma and follicular adenoma of the thyroid gland. ( 25810698 )
2015
14
Determination-of apoptosis and cell cycle modulators (p16, p21, p27, p53, BCL-2, Bax, BCL-xL, and cyclin D1) in thyroid follicular carcinoma, follicular adenoma, and adenomatous nodules via a tissue microarray method. ( 26422859 )
2015
15
Identification of Novel Biomarker and Therapeutic Target Candidates for Diagnosis and Treatment of Follicular Adenoma. ( 26543076 )
2015
16
Not All Post-FNA Spindle Cell Proliferations in the Thyroid Are of Myofibroblastic Origin: Follicular Adenoma with Spindle Cell Metaplasia. ( 26490689 )
2015
17
Better understanding in the differentiation of thyroid follicular adenoma, follicular carcinoma, and follicular variant of papillary carcinoma: a retrospective study. ( 25309594 )
2014
18
Meningioma like tumour of thyroid: a rare variant of follicular adenoma. ( 24640816 )
2014
19
Sonographic features of thyroid follicular carcinoma in comparison with thyroid follicular adenoma. ( 24449724 )
2014
20
How should a follicular adenoma with papillary architecture be classified on thyroid FNA? Case report with histological correlation. ( 25073478 )
2014
21
Thyroid Follicular Adenoma with Accumulation of Collagen Type IV in a Common Marmoset (Callithrix jacchus). ( 24060155 )
2013
22
Unusual association of primary hyperparathyroidism, papillary thyroid carcinoma, and follicular adenoma in a young female. ( 23776923 )
2013
23
Molecular differences between human thyroid follicular adenoma and carcinoma revealed by analysis of a murine model of thyroid cancer. ( 23751876 )
2013
24
The unique liquid-based cytologic findings of thyroid signet-ring follicular adenoma: a report of two cases with fine needle aspiration cytology. ( 23220878 )
2013
25
A case of asymptomatic riedel thyroiditis with follicular adenoma in a patient with a multinodular goiter: an unusual association. ( 24783021 )
2012
26
Follicular adenoma with extensive extracellular mucin deposition: report on two cases. ( 23236259 )
2012
27
Examination of CD26/DPPIV, p53, and PTEN expression in thyroid follicular adenoma. ( 22086610 )
2012
28
Value of immunohistochemical expression of p27 and galectin-3 in differentiation between follicular adenoma and follicular carcinoma. ( 22553813 )
2012
29
Fine needle aspiration biopsy of an unusual follicular adenoma with sebaceous-like features. ( 22527948 )
2012
30
Genetic studies in a coexistence of acromegaly, pheochromocytoma, gastrointestinal stromal tumor (GIST) and thyroid follicular adenoma. ( 23295290 )
2012
31
Follicular adenoma presenting as lateral aberrant thyroid. ( 21854673 )
2012
32
Squamous cell components in a thyroid follicular adenoma: significant evidence of follicular cell origin by histomorphological, immunohistochemical and molecular analyses. ( 21951666 )
2011
33
Thyroid follicular adenoma composed of lipid-rich cells. ( 21165779 )
2011
34
Comparison of proliferating cell nuclear antigen, thyroid transcription factor-1, Ki-67, p63, p53 and high-molecular weight cytokeratin expressions in papillary thyroid carcinoma, follicular carcinoma, and follicular adenoma. ( 21315633 )
2011
35
Cytologic features of focal papillary thyroid carcinoma arising within follicular adenoma: a masked cytomorphologic analysis of 17 cases. ( 22156462 )
2011
36
Follicular adenoma and carcinoma of the thyroid gland. ( 21482585 )
2011
37
Synchronous occurrence of anaplastic, follicular and papillary carcinomas with follicular adenoma in thyroid gland. ( 21623114 )
2011
38
Differential diagnosis of follicular cancer and follicular adenoma using an expert system based on a set of qualitative signs of cell atypia. ( 22611752 )
2011
39
Comment on: synchronous occurrence of anaplastic, follicular, and papillary carcinoma with follicular adenoma in thyroid gland. ( 21623130 )
2011
40
Kikuchi disease and thyroid follicular adenoma. ( 20859864 )
2010
41
Synchronous occurrence of anaplastic, follicular and papillary carcinomas with follicular adenoma in thyroid gland. ( 20551551 )
2010
42
Signet-ring cell follicular adenoma of the thyroid. ( 20132181 )
2010
43
Clear cell follicular adenoma of the thyroid--a challenge in intra-operative diagnostics. ( 19235130 )
2010
44
Expression of the sonic hedgehog pathway molecules in synchronous follicular adenoma and papillary carcinoma of the thyroid gland in predicting malignancy. ( 20797751 )
2010
45
Osseous metaplasia and mature bone formation with extramedullary hematopoiesis in follicular adenoma of thyroid gland. ( 19679966 )
2009
46
Thyroid follicular adenoma producing parathyroid hormone-related protein with a normal serum calcium level. ( 19915296 )
2009
47
Differential expression of CK 19 in follicular adenoma, well-differentiated tumour of uncertain malignant potential (WDT-UMP) and follicular variant of papillary carcinoma. ( 19213370 )
2009
48
Identification and functional characterization of two novel activating thyrotropin receptor mutants in toxic thyroid follicular adenomas. ( 19499991 )
2009
49
Are there any specific ultrasound findings of nodular hyperplasia ("leave me alone" lesion) to differentiate it from follicular adenoma? ( 19241229 )
2009
50
Fine-needle aspiration of follicular adenoma versus parathyroid adenoma: the utility of multispectral imaging in differentiating lesions with subtle cytomorphologic differences. ( 18085636 )
2008

Variations for Follicular Adenoma

ClinVar genetic disease variations for Follicular Adenoma:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 MINPP1 MINPP1, IVS3, T-A, +34 single nucleotide variant Pathogenic

Expression for Follicular Adenoma

Search GEO for disease gene expression data for Follicular Adenoma.

Pathways for Follicular Adenoma

Pathways related to Follicular Adenoma according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 12.15 CDKN1B PAX8 PTEN RET
2
Show member pathways
11.85 PAX8 TG TPO TSHR
3 10.96 CDKN1B PAX8 TSHR
4 9.58 TG TPO TSHR

GO Terms for Follicular Adenoma

Biological processes related to Follicular Adenoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 negative regulation of epithelial to mesenchymal transition GO:0010719 9.4 NKX2-1 PTEN
2 response to pain GO:0048265 9.37 CALCA RET
3 endothelial cell migration GO:0043542 9.33 CALCA DPP4 PTEN
4 hormone biosynthetic process GO:0042446 9.32 TG TPO
5 positive regulation of adenylate cyclase activity GO:0045762 9.26 CALCA TSHR
6 thyroid-stimulating hormone signaling pathway GO:0038194 8.96 PAX8 TSHR
7 thyroid gland development GO:0030878 8.8 NKX2-1 PAX8 TG

Molecular functions related to Follicular Adenoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 protein complex binding GO:0032403 9.46 CALCA CDKN1B KRT19 TSHR
2 inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity GO:0051717 8.96 MINPP1 PTEN
3 thyroid-stimulating hormone receptor activity GO:0004996 8.62 PAX8 TSHR

Sources for Follicular Adenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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