MCID: FLL031
MIFTS: 42

Follicular Adenoma malady

Categories: Cancer diseases, Endocrine diseases

Aliases & Classifications for Follicular Adenoma

Aliases & Descriptions for Follicular Adenoma:

Name: Follicular Adenoma 12 14 69
Follicular Adenoma of the Thyroid Gland 12
Thyroid Gland Follicular Adenoma 69
Thyroid Follicular Adenoma 12
Adenoma Follicular 52

Classifications:



External Ids:

Disease Ontology 12 DOID:6204
MeSH 42 D000236
SNOMED-CT 64 55021007
UMLS 69 C0205647

Summaries for Follicular Adenoma

MalaCards based summary : Follicular Adenoma, also known as follicular adenoma of the thyroid gland, is related to atypical follicular adenoma and oxyphilic adenoma. An important gene associated with Follicular Adenoma is LGALS3 (Galectin 3), and among its related pathways/superpathways are Pathways in cancer and Insulin secretion. The drugs Doxorubicin and Cisplatin have been mentioned in the context of this disorder. Affiliated tissues include thyroid, bone and colon, and related phenotypes are Increased shRNA abundance and endocrine/exocrine gland

Related Diseases for Follicular Adenoma

Diseases related to Follicular Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 94)
id Related Disease Score Top Affiliating Genes
1 atypical follicular adenoma 12.1
2 oxyphilic adenoma 10.9
3 adenoma 10.6
4 thyroiditis 10.6
5 endophthalmitis 10.3 CALCA TG
6 fibrous meningioma 10.3 TG TPO
7 corneal ectasia 10.3 CALCA TG
8 superior vena cava angiosarcoma 10.3 CALCA TG
9 premature closure of the arterial duct 10.3 TG TPO
10 chromophil adenoma of the kidney 10.3 NKX2-1 TG
11 perineural angioma 10.2 CALCA TG
12 cowden syndrome 3 10.2 CALCA RET TG
13 glossopharyngeal motor neuropathy 10.2 CDH1 TG
14 bizarre leiomyoma 10.2 CALCA NKX2-1 TG
15 urinary tract papillary transitional cell benign neoplasm 10.2 CALCA NKX2-1 RET
16 papillary carcinoma 10.2
17 endocrine gland cancer 10.2 CALCA NKX2-1 RET
18 infiltrative basal cell carcinoma 10.1 CDH1 KRT19
19 kidney disease 10.1 NKX2-1 TG
20 mitochondrial dna depletion syndrome 5 10.1 CALCA KRT19 NKX2-1
21 bladder flat intraepithelial lesion 10.1 PAX8 TG
22 aneurysm 10.1 CALCA CDKN1B RET
23 acute hemorrhagic encephalitis 10.1 RET TG TSHR
24 background diabetic retinopathy 10.1 TG TPO TSHR
25 conjunctival deposit 10.1 TG TPO TSHR
26 tick paralysis 10.1 TG TPO
27 mixed eosinophil-basophil adenoma 10.1 TG TPO TSHR
28 hypothyroidism, congenital, nongoitrous, 1 10.1 TG TPO TSHR
29 subserous uterine fibroid 10.1 CALCA CDKN1B RET
30 denys-drash syndrome 10.1 TG TPO TSHR
31 janus kinase-3 deficiency 10.1 TG TPO TSHR
32 neutropenia, severe congenital, 5, autosomal recessive 10.1 CALCA NKX2-1 RET TG
33 glomangiomyoma 10.1 TG TPO TSHR
34 childhood teratocarcinoma of the testis 10.1 CALCA PTEN RET TG
35 sengers syndrome 10.1 CDH1 LGALS3 PTEN
36 pulsating exophthalmos 10.1 TG TPO TSHR
37 parietal lobe neoplasm 10.1 CALCA TG
38 echinostomiasis 10.0 SLC26A4 TG
39 krabbe disease 10.0 CALCA TG TPO TSHR
40 endemic goiter 10.0 CALCA TG TPO TSHR
41 broad ligament malignant neoplasm 10.0 CALCA TG TPO TSHR
42 infertility 10.0 KRT19 LGALS3 NKX2-1 RET TG
43 proctitis 10.0 CDH1 KRT19 PTEN
44 parachordoma 10.0 NKX2-1 RET TG TSHR
45 in situ pulmonary adenocarcinoma 10.0 CDH1 CDKN1B KRT19
46 monkeypox 10.0 PAX8 PTEN
47 articulation disorder 10.0 TG TPO TSHR
48 nevoid hypermelanosis, linear and whorled 10.0 CDH1 PTEN RET
49 potter's syndrome 10.0 PAX8 TSHR
50 tmem70 defect 10.0 NKX2-1 PAX8 RET TG

Graphical network of the top 20 diseases related to Follicular Adenoma:



Diseases related to Follicular Adenoma

Symptoms & Phenotypes for Follicular Adenoma

GenomeRNAi Phenotypes related to Follicular Adenoma according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance GR00327-A 8.92 CALCA CDKN1B LGALS3 MCM2

MGI Mouse Phenotypes related to Follicular Adenoma:

44 (show all 18)
id Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 10.35 PAX8 PTEN RET SLC26A4 TG TPO
2 growth/size/body region MP:0005378 10.3 CDH1 CDKN1B DPP4 KRT19 MCM2 NKX2-1
3 homeostasis/metabolism MP:0005376 10.27 CDH1 CDKN1B DPP4 LGALS3 NKX2-1 PAX8
4 behavior/neurological MP:0005386 10.23 NKX2-1 PAX8 PTEN RET CDKN1B LGALS3
5 cellular MP:0005384 10.21 CDH1 CDKN1B KRT19 LGALS3 MCM2 NKX2-1
6 digestive/alimentary MP:0005381 10.2 CDH1 CDKN1B KRT19 LGALS3 MCM2 NKX2-1
7 mortality/aging MP:0010768 10.2 CDH1 CDKN1B KRT19 LGALS3 MCM2 NKX2-1
8 cardiovascular system MP:0005385 10.17 CDH1 CDKN1B KRT19 LGALS3 NKX2-1 PAX8
9 nervous system MP:0003631 10.14 CDKN1B KRT19 LGALS3 MCM2 NKX2-1 PAX8
10 immune system MP:0005387 10.13 CDH1 CDKN1B LGALS3 MCM2 PTEN RET
11 neoplasm MP:0002006 10.09 CDH1 CDKN1B KRT19 LGALS3 MCM2 NKX2-1
12 hearing/vestibular/ear MP:0005377 9.91 CDKN1B PAX8 SLC26A4 TPO TSHR
13 normal MP:0002873 9.87 CDH1 KRT19 MCM2 NKX2-1 PAX8 PTEN
14 no phenotypic analysis MP:0003012 9.85 CDH1 CDKN1B KRT19 NKX2-1 PAX8 RET
15 reproductive system MP:0005389 9.85 NKX2-1 PAX8 PTEN RET SLC26A4 TSHR
16 renal/urinary system MP:0005367 9.73 SLC26A4 CDKN1B LGALS3 PAX8 PTEN RET
17 respiratory system MP:0005388 9.43 CDKN1B LGALS3 MCM2 NKX2-1 PTEN RET
18 skeleton MP:0005390 9.28 NKX2-1 PAX8 PTEN SLC26A4 TPO TSHR

Drugs & Therapeutics for Follicular Adenoma

Drugs for Follicular Adenoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 39)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Doxorubicin Approved, Investigational Phase 2 23214-92-8 31703
2
Cisplatin Approved Phase 2 15663-27-1 84093 441203 2767
3
Tamoxifen Approved Phase 2 10540-29-1 2733526
4
Doxil Approved June 1999 Phase 2 31703
5 Selective Estrogen Receptor Modulators Phase 2
6 Topoisomerase Inhibitors Phase 2
7 Hormone Antagonists Phase 2
8 Hormones Phase 2,Phase 1
9 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
10 Estrogen Antagonists Phase 2
11 Anti-Bacterial Agents Phase 2
12 Estrogen Receptor Modulators Phase 2
13 Estrogens Phase 2
14 Liver Extracts Phase 2
15 Antibiotics, Antitubercular Phase 2
16 Antineoplastic Agents, Hormonal Phase 2,Phase 1
17 Bone Density Conservation Agents Phase 2
18 Citrate Nutraceutical Phase 2
19
Citric Acid Nutraceutical, Vet_approved Phase 2 77-92-9 311
20 lysine Nutraceutical Phase 2
21
Paclitaxel Approved, Vet_approved Phase 1 33069-62-4 36314
22
Carboplatin Approved Phase 1 41575-94-4 10339178 498142 38904
23
Octreotide Approved, Investigational Phase 1 83150-76-9 383414 6400441
24
Trastuzumab Approved, Investigational Phase 1 180288-69-1 9903
25
Somatostatin Approved Phase 1 38916-34-6, 51110-01-1 53481605
26 pancreatic polypeptide Phase 1
27 Adjuvants, Immunologic Phase 1
28 Gastrointestinal Agents Phase 1
29 Albumin-Bound Paclitaxel Phase 1
30 Angiogenesis Inhibitors Phase 1
31 Angiogenesis Modulating Agents Phase 1
32 Edotreotide Phase 1
33 Interleukin-12 Phase 1
34 Radiopharmaceuticals Phase 1
35 Antimitotic Agents Phase 1
36 Antineoplastic Agents, Phytogenic Phase 1
37
Formaldehyde Approved, Vet_approved 50-00-0 712
38
Iodine 7553-56-2 807
39 cadexomer iodine

Interventional clinical trials:

(show all 12)
id Name Status NCT ID Phase
1 Combination Chemotherapy and Tamoxifen in Treating Patients With Solid Tumors Completed NCT00002608 Phase 2
2 Tazemetostat Rollover Study (TRuST): An Open-Label Rollover Study Recruiting NCT02875548 Phase 2
3 Effect of Pasireotide Long Acting Release (LAR) on Gonadotroph Adenomas Terminated NCT00929669 Phase 2
4 Interleukin-12 and Trastuzumab in Treating Patients With Cancer That Has High Levels of HER2/Neu Completed NCT00004074 Phase 1
5 Yttrium Y 90 SMT 487 in Treating Patients With Refractory or Recurrent Cancer Completed NCT00006368 Phase 1
6 Evaluation of a New CZT System Unknown status NCT01084356
7 Biomarkers to Distinguish Benign From Malignant Thyroid Neoplasm Completed NCT01433809
8 Molecular Markers in Thyroid Cancer Completed NCT00598364
9 Expression of NIS Protein and mRNA in Thyroid Tumors Completed NCT00459498
10 Alterations in Muscle's Functional Characteristics After Parathyroid Surgery for Primary Hyperparathyroidism. Recruiting NCT03091140
11 ctDNA in Patients With Thyroid Nodules Recruiting NCT02778412
12 Expression of Protein Convertases in Thyroid Nodules Enrolling by invitation NCT03160482

Search NIH Clinical Center for Follicular Adenoma

Genetic Tests for Follicular Adenoma

Anatomical Context for Follicular Adenoma

MalaCards organs/tissues related to Follicular Adenoma:

39
Thyroid, Bone, Colon, Breast

Publications for Follicular Adenoma

Articles related to Follicular Adenoma:

(show top 50) (show all 118)
id Title Authors Year
1
Papillary Thyroid Carcinoma Arising Within a Follicular Adenoma: A Case Report, Ultrasound Features, and Considerations. ( 27110655 )
2016
2
Association between p53-binding protein 1 expression and genomic instability in oncocytic follicular adenoma of the thyroid. ( 26935218 )
2016
3
Thyroid follicular adenoma with numerous intracytoplasmic lumina mimicking yellow bodies: a case report. ( 27146719 )
2016
4
Can Nodular Hyperplasia of the Thyroid Gland be Differentiated From Follicular Adenoma and Follicular Carcinoma by Ultrasonography? ( 27870787 )
2016
5
Expression of ARE-binding proteins AUF1 and HuR in follicular adenoma and carcinoma of thyroid gland. ( 26925783 )
2016
6
Mutational burdens and evolutionary ages of thyroid follicular adenoma are comparable to those of follicular carcinoma. ( 27626165 )
2016
7
Incidental ectopic thyroid follicular adenoma on myocardial perfusion imaging. ( 26122882 )
2016
8
Determination-of apoptosis and cell cycle modulators (p16, p21, p27, p53, BCL-2, Bax, BCL-xL, and cyclin D1) in thyroid follicular carcinoma, follicular adenoma, and adenomatous nodules via a tissue microarray method. ( 26422859 )
2015
9
Identification of Novel Biomarker and Therapeutic Target Candidates for Diagnosis and Treatment of Follicular Adenoma. ( 26543076 )
2015
10
Not All Post-FNA Spindle Cell Proliferations in the Thyroid Are of Myofibroblastic Origin: Follicular Adenoma with Spindle Cell Metaplasia. ( 26490689 )
2015
11
Risk of thyroid follicular adenoma among children and adolescents in Belarus exposed to iodine-131 after the Chornobyl accident. ( 26443421 )
2015
12
Appearance of HA1rthle cell carcinoma soon after surgical extirpation of HA1rthle cell adenoma and follicular adenoma of the thyroid gland. ( 25810698 )
2015
13
How should a follicular adenoma with papillary architecture be classified on thyroid FNA? Case report with histological correlation. ( 25073478 )
2014
14
Sonographic features of thyroid follicular carcinoma in comparison with thyroid follicular adenoma. ( 24449724 )
2014
15
Meningioma like tumour of thyroid: a rare variant of follicular adenoma. ( 24640816 )
2014
16
Better understanding in the differentiation of thyroid follicular adenoma, follicular carcinoma, and follicular variant of papillary carcinoma: a retrospective study. ( 25309594 )
2014
17
The unique liquid-based cytologic findings of thyroid signet-ring follicular adenoma: a report of two cases with fine needle aspiration cytology. ( 23220878 )
2013
18
Thyroid Follicular Adenoma with Accumulation of Collagen Type IV in a Common Marmoset (Callithrix jacchus). ( 24060155 )
2013
19
Molecular differences between human thyroid follicular adenoma and carcinoma revealed by analysis of a murine model of thyroid cancer. ( 23751876 )
2013
20
Unusual association of primary hyperparathyroidism, papillary thyroid carcinoma, and follicular adenoma in a young female. ( 23776923 )
2013
21
Examination of CD26/DPPIV, p53, and PTEN expression in thyroid follicular adenoma. ( 22086610 )
2012
22
Follicular adenoma with extensive extracellular mucin deposition: report on two cases. ( 23236259 )
2012
23
Value of immunohistochemical expression of p27 and galectin-3 in differentiation between follicular adenoma and follicular carcinoma. ( 22553813 )
2012
24
A case of asymptomatic riedel thyroiditis with follicular adenoma in a patient with a multinodular goiter: an unusual association. ( 24783021 )
2012
25
Fine needle aspiration biopsy of an unusual follicular adenoma with sebaceous-like features. ( 22527948 )
2012
26
Follicular adenoma presenting as lateral aberrant thyroid. ( 21854673 )
2012
27
Genetic studies in a coexistence of acromegaly, pheochromocytoma, gastrointestinal stromal tumor (GIST) and thyroid follicular adenoma. ( 23295290 )
2012
28
Synchronous occurrence of anaplastic, follicular and papillary carcinomas with follicular adenoma in thyroid gland. ( 21623114 )
2011
29
Squamous cell components in a thyroid follicular adenoma: significant evidence of follicular cell origin by histomorphological, immunohistochemical and molecular analyses. ( 21951666 )
2011
30
Cytologic features of focal papillary thyroid carcinoma arising within follicular adenoma: a masked cytomorphologic analysis of 17 cases. ( 22156462 )
2011
31
Follicular adenoma and carcinoma of the thyroid gland. ( 21482585 )
2011
32
Comment on: synchronous occurrence of anaplastic, follicular, and papillary carcinoma with follicular adenoma in thyroid gland. ( 21623130 )
2011
33
Comparison of proliferating cell nuclear antigen, thyroid transcription factor-1, Ki-67, p63, p53 and high-molecular weight cytokeratin expressions in papillary thyroid carcinoma, follicular carcinoma, and follicular adenoma. ( 21315633 )
2011
34
Thyroid follicular adenoma composed of lipid-rich cells. ( 21165779 )
2011
35
Differential diagnosis of follicular cancer and follicular adenoma using an expert system based on a set of qualitative signs of cell atypia. ( 22611752 )
2011
36
Expression of the sonic hedgehog pathway molecules in synchronous follicular adenoma and papillary carcinoma of the thyroid gland in predicting malignancy. ( 20797751 )
2010
37
Kikuchi disease and thyroid follicular adenoma. ( 20859864 )
2010
38
Synchronous occurrence of anaplastic, follicular and papillary carcinomas with follicular adenoma in thyroid gland. ( 20551551 )
2010
39
Signet-ring cell follicular adenoma of the thyroid. ( 20132181 )
2010
40
Clear cell follicular adenoma of the thyroid--a challenge in intra-operative diagnostics. ( 19235130 )
2010
41
Differential expression of CK 19 in follicular adenoma, well-differentiated tumour of uncertain malignant potential (WDT-UMP) and follicular variant of papillary carcinoma. ( 19213370 )
2009
42
Identification and functional characterization of two novel activating thyrotropin receptor mutants in toxic thyroid follicular adenomas. ( 19499991 )
2009
43
Osseous metaplasia and mature bone formation with extramedullary hematopoiesis in follicular adenoma of thyroid gland. ( 19679966 )
2009
44
Thyroid follicular adenoma producing parathyroid hormone-related protein with a normal serum calcium level. ( 19915296 )
2009
45
Are there any specific ultrasound findings of nodular hyperplasia ("leave me alone" lesion) to differentiate it from follicular adenoma? ( 19241229 )
2009
46
Correspondence between ultrasonography and histological features in a single thyroid nodule with coexisting follicular adenoma and papillary carcinoma. ( 18631017 )
2008
47
Fine-needle aspiration of follicular adenoma versus parathyroid adenoma: the utility of multispectral imaging in differentiating lesions with subtle cytomorphologic differences. ( 18085636 )
2008
48
Follicular adenoma in a thyroglossal duct. ( 17684668 )
2007
49
Pten loss in the mouse thyroid causes goiter and follicular adenomas: insights into thyroid function and Cowden disease pathogenesis. ( 17283127 )
2007
50
111In-Pentetreotide uptake in a follicular adenoma of the thyroid gland: a pitfall for 111In-Pentetreotide scintigraphy. ( 17173778 )
2006

Variations for Follicular Adenoma

ClinVar genetic disease variations for Follicular Adenoma:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 MINPP1 MINPP1, IVS3, T-A, +34 single nucleotide variant Pathogenic

Expression for Follicular Adenoma

Search GEO for disease gene expression data for Follicular Adenoma.

Pathways for Follicular Adenoma

Pathways related to Follicular Adenoma according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 12.25 CDH1 CDKN1B PAX8 PTEN RET
2
Show member pathways
11.75 PAX8 SLC26A4 TG TPO TSHR
3 11.33 CDKN1B PAX8 TSHR
4 10.79 CDH1 PAX8 RET
5 9.58 TG TPO TSHR

GO Terms for Follicular Adenoma

Biological processes related to Follicular Adenoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.73 CDH1 CDKN1B PTEN RET
2 negative regulation of epithelial to mesenchymal transition GO:0010719 9.48 NKX2-1 PTEN
3 response to pain GO:0048265 9.46 CALCA RET
4 cellular response to lithium ion GO:0071285 9.4 CDH1 CDKN1B
5 hormone biosynthetic process GO:0042446 9.37 TG TPO
6 endothelial cell migration GO:0043542 9.33 CALCA DPP4 PTEN
7 positive regulation of adenylate cyclase activity GO:0045762 9.32 CALCA TSHR
8 iodide transport GO:0015705 9.26 SLC26A4 TG
9 thyroid-stimulating hormone signaling pathway GO:0038194 8.96 PAX8 TSHR
10 thyroid gland development GO:0030878 8.8 NKX2-1 PAX8 TG

Molecular functions related to Follicular Adenoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 protein complex binding GO:0032403 9.26 CALCA CDKN1B KRT19 TSHR
2 thyroid-stimulating hormone receptor activity GO:0004996 8.62 PAX8 TSHR

Sources for Follicular Adenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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