MCID: FLL031
MIFTS: 49

Follicular Adenoma malady

Endocrine diseases category

Summaries for Follicular Adenoma

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63Wikipedia, 32MalaCards
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Wikipedia:63 A thyroid adenoma is a benign tumor of the thyroid gland. more...

MalaCards: Follicular Adenoma, also known as follicular adenoma of the thyroid gland, is related to adenoma and follicular thyroid carcinoma. An important gene associated with Follicular Adenoma is LGALS3 (lectin, galactoside-binding, soluble, 3), and among its related pathways are Bisphosphonate Pathway, Pharmacodynamics and GRB2:SOS provides linkage to MAPK signaling for Intergrins . The compounds cycloheximide and estrogen have been mentioned in the context of this disorder. Affiliated tissues include thyroid, bone and breast, and related mouse phenotypes are homeostasis/metabolism and endocrine/exocrine gland.

Aliases & Classifications for Follicular Adenoma

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8Disease Ontology, 10DISEASES, 60UMLS, 44Novoseek, 34MeSH, 56SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Endocrine diseases


Aliases & Descriptions:

follicular adenoma 8 10 60
follicular adenoma of the thyroid gland 8
thyroid follicular adenoma 8
adenoma follicular 44


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Disease Ontology8 DOID:6204
SNOMED-CT56 55021007
MeSH34 D000236

Related Diseases for Follicular Adenoma

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17GeneCards, 18GeneDecks
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Diseases related to Follicular Adenoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 101)
idRelated DiseaseScoreTop Affiliating Genes
1adenoma31.4CP, S100A4, LGALS3, ACPP, KRT19, HMGCR
2follicular thyroid carcinoma31.1DPP4, RET, KRT19, LGALS3
3papillary carcinoma30.9S100A4, DPP4, CDKN1B, RET, KRT19, LGALS3
4papillary thyroid carcinoma30.9S100A4, MEN1, RET, RAP1A, KRT19, LGALS3
5parathyroid adenoma30.4MEN1, CDKN1B, RET, PTHLH, LGALS3
6meningioma30.2MEN1
7goiter30.2S100A4, RET, LGALS3
8primary hyperparathyroidism30.2MEN1, RET, PTHLH
9hyperparathyroidism30.2PTHLH, RET, CDKN1B, MEN1
10acromegaly30.0MEN1
11parathyroid carcinoma30.0RET, MEN1
12autoimmune thyroiditis30.0RET, KRT19, LGALS3
13pheochromocytoma30.0IL6R, RET, MEN1
14astrocytoma30.0CDKN1B, RAP1A, LGALS3
15colon adenocarcinoma30.0LGALS3, CDKN1B, DPP4, S100A4
16thyroid cancer30.0CDKN1B, RET, KRT19, LGALS3
17adenocarcinoma29.9S100A4, MEN1, DPP4, CDKN1B, MCM2, MCM7
18thyroiditis11.0
19papillary adenoma10.6
20clear cell adenoma10.3
21atypical follicular adenoma10.3
22pregnancy adenoma10.1
23acute thyroiditis10.0
24oxyphilic adenoma10.0
25sebaceous adenoma10.0
26gastrointestinal stromal tumor10.0
27spindle cell carcinoma10.0
28cowden disease10.0
29gastrointestinal adenoma10.0
30breast adenoma10.0
31cerebellar astrocytoma10.0
32cystic teratoma10.0
33hemangioma10.0
34mediastinitis10.0
35papilloma10.0
36renal adenoma10.0
37renal cell carcinoma10.0
38thyroid adenoma10.0
39prostatitis10.0ACPP
40nasopharyngitis10.0DPP4
41laryngeal squamous cell carcinoma10.0KRT19, MCM2
42oligodendroglioma10.0LGALS3, MCM7
43paraganglioma10.0MEN1, RET
44cervical adenocarcinoma10.0CDKN1B
45graves' disease10.0LGALS3, IL6R
46myeloid leukemia10.0RAP1A
47hyperparathyroidism-jaw tumor syndrome10.0MEN1, RET
48hepatitis10.0CP, DPP4
49ovarian cancer10.0IL6R, CDKN1B
50von hippel-lindau disease10.0RET, MEN1

Graphical network of the top 20 diseases related to Follicular Adenoma:



Diseases related to follicular adenoma

Clinical Features for Follicular Adenoma

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Drugs & Therapeutics for Follicular Adenoma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Follicular Adenoma

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Anatomical Context for Follicular Adenoma

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32MalaCards
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MalaCards organs/tissues related to Follicular Adenoma:

32
Thyroid, Bone, Breast, Pituitary, Colon

Animal Models for Follicular Adenoma or affiliated genes

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36MGI
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Publications for Follicular Adenoma

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50PubMed
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Articles related to Follicular Adenoma:

(show top 50)    (show all 136)
idTitleAuthorsYear
1
Unusual association of primary hyperparathyroidism, papillary thyroid carcinoma, and follicular adenoma in a young female. (23776923)
2013
2
Thyroid Follicular Adenoma with Accumulation of Collagen Type IV in a Common Marmoset (Callithrix jacchus). (24060155)
2013
3
Molecular differences between human thyroid follicular adenoma and carcinoma revealed by analysis of a murine model of thyroid cancer. (23751876)
2013
4
The unique liquid-based cytologic findings of thyroid signet-ring follicular adenoma: a report of two cases with fine needle aspiration cytology. (23220878)
2013
5
Case of tubular apocrine adenoma with follicular differentiation located on the trunk. (21906134)
2012
6
Comment on: synchronous occurrence of anaplastic, follicular, and papillary carcinoma with follicular adenoma in thyroid gland. (21623130)
2011
7
Higher intratumoral expression of CD1a, tryptase, and CD68 in a follicular variant of papillary thyroid carcinoma compared to adenomas: correlation with clinical and pathological parameters. (22007938)
2011
8
Follicular thyroid adenoma with eggshell calcification presenting as an intensely hypermetabolic lesion on 18F-FDG PET/CT. (19655340)
2010
9
Synchronous occurrence of anaplastic, follicular and papillary carcinomas with follicular adenoma in thyroid gland. (20551551)
2010
10
Signet-ring cell follicular adenoma of the thyroid. (20132181)
2010
11
Thyroid follicular adenoma producing parathyroid hormone-related protein with a normal serum calcium level. (19915296)
2009
12
Are there any specific ultrasound findings of nodular hyperplasia ("leave me alone" lesion) to differentiate it from follicular adenoma? (19241229)
2009
13
Incidental parathyroid adenoma mimicking tumor recurrence in a patient with follicular thyroid carcinoma. (16424689)
2006
14
The efficacy of the thyroid peroxidase marker for distinguishing follicular thyroid carcinoma from follicular adenoma. (16614712)
2006
15
Human galectin-3 immunoexpression in thyroid follicular adenomas with cell atypia. (15887854)
2005
16
Meningioma-like tumor of the thyroid: a previously undescribed variant of follicular adenoma. (15891903)
2005
17
Circulating tumor cells detected by reverse transcription-polymerase chain reaction for carcinoembryonic antigen mRNA: distinguishing follicular thyroid carcinoma from adenoma. (15855928)
2005
18
Thyroid follicular adenomas may display features of follicular carcinoma and follicular variant of papillary carcinoma. (15588246)
2004
19
Distinctive expression of STAT3 in papillary thyroid carcinomas and a subset of follicular adenomas. (12647789)
2003
20
Differential expression of IGFBP-5 and two human ESTs in thyroid glands with goiter, adenoma and papillary or follicular carcinomas. (12618333)
2003
21
Tumor-to-tumor metastases to follicular adenoma of thyroid: case report and review of the literature. (17159402)
2002
22
Massive bleeding from an ectopic lingual thyroid follicular adenoma during pregnancy. (12019490)
2002
23
Expression of PAX8-PPAR gamma 1 rearrangements in both follicular thyroid carcinomas and adenomas. (12161538)
2002
24
Follicular adenoma of the thyroid gland with extensive bone metaplasia. (11718227)
2001
25
Follicular adenoma of thyroid associated with mediastinal malignant hemangioendothelioma, masquerading as malignant retrosternal goiter. (11573559)
2001
26
Long-term follow-up of contralateral lobe in patients hemithyroidectomized for solitary follicular adenoma. (11678834)
2001
27
The role of frozen section, gender, age, and tumor size in the differentiation of follicular adenoma from carcinoma: a meta-analysis. (11114645)
2000
28
Solitary follicular thyroid carcinoma of the skull base and its differentiation from ectopic adenoma--review, use of galectin-3 and report of a new case. (10996713)
2000
29
Discordant uptake of Tl-201 and Tc-99m MIBI in a patient with follicular adenoma. (10830533)
2000
30
MIB-1 immunohistometry of follicular adenoma and follicular carcinoma of the thyroid gland. (10872040)
2000
31
Hyperfunctioning thyroid adenoma concomitant with papillary thyroid carcinoma, follicular thyroid adenoma and primary hyperparathyroidism. (9625447)
1998
32
Clear-Cell Follicular Adenoma of Ectopic Thyroid in the Submandibular Region. (12114783)
1998
33
Clear cell follicular adenoma of the thyroid: a case report. (8872434)
1996
34
Carcinomas metastatic to follicular adenomas of the thyroid gland. Report of two cases. (7514864)
1994
35
Transforming growth factor-beta 1 is more expressed in thyroid follicular adenoma than in normal tissue. (8077617)
1994
36
Numerical aberrations, including trisomy 22 as the sole anomaly, are recurrent in follicular thyroid adenomas. (7691161)
1993
37
Estrogen-receptor protein in thyroid neoplasms. An immunohistochemical analysis of papillary carcinoma, follicular carcinoma, and follicular adenoma. (1768209)
1991
38
Follicular adenoma of the thyroid gland with extensive chondroid metaplasia. (2045081)
1991
39
Deletion of part of the long arm of chromosome 13 as the only karyotypic aberration in a follicular thyroid adenoma. (1756473)
1991
40
Intraluminal crystalloids in follicular adenoma of the thyroid. (1898242)
1991
41
Cytogenetic analyses of three papillary carcinomas and a follicular adenoma of the thyroid. (2293877)
1990
42
Follicular thyroid adenoma: signet ring cell variant. (2363591)
1990
43
Sources and nature of variation in DNA analysis of follicular thyroid adenoma. (2696941)
1989
44
Clear cell follicular adenoma of the thyroid. (3821125)
1987
45
Spontaneous thyroid follicular adenoma in a laboratory mouse (Mus musculus). (3803433)
1986
46
Follicular adenoma of the thyroid with intranuclear vacuoles and clear nuclei. A case report. (6592921)
1984
47
Immunoelectron microscopic localization of thyroglobulin in human follicular adenoma. (6367352)
1983
48
Computation of preoperative diagnosis probability for follicular adenoma and carcinoma of the thyroid on aspiration smears. (7073140)
1982
49
A follicular adenoma arising from the thyroid tissue of a benign cystic teratoma during pregnancy--lightmicroscopical, ultrastructural and endocrinological studies. (7240873)
1980
50
Planimetric studies on fine needle aspirates from follicular adenoma and follicular carcinoma of the thyroid. (6989141)
1980

Genetic Variations for Follicular Adenoma

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Expression for genes affiliated with Follicular Adenoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Follicular Adenoma

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Pathways for genes affiliated with Follicular Adenoma

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49PharmGKB, 53Reactome, 37NCBI BioSystems Database, 29KEGG, 4Cell Signaling Technology
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Compounds for genes affiliated with Follicular Adenoma

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44Novoseek, 24HMDB, 11DrugBank, 59Tocris Bioscience, 49PharmGKB, 28IUPHAR
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Compounds related to Follicular Adenoma according to GeneCards/GeneDecks:

(show top 50)    (show all 51)
idCompoundScoreTop Affiliating Genes
1cycloheximide4410.7DPP4
2estrogen4410.6ACPP
3glycogen44 2411.4PTHLH, IL6R, CDKN1B
4estradiol44 11 2412.4ACPP, PTHLH
5carbohydrates4410.3DPP4, KRT19, CP
6leptomycin b44 5911.3CDKN1B, PTHLH, LGALS3
7paclitaxel44 49 1112.3KRT19, CDKN1B
8heparin44 28 11 2413.2DPP4, CDKN1B, HMGCR, CP
9Alpha-D-Mannose1110.2ACPP, IL6R, DPP4
10sodium dodecylsulfate4410.2CP
11hematoxylin4410.1LGALS3, ACPP, KRT19
12methotrexate44 49 1112.1HMGCR, IL6R, CDKN1B, DPP4
13perillyl alcohol44 2411.0HMGCR, RAP1A
14matrigel4410.0S100A4, DPP4, KRT19, PTHLH, LGALS3
15lovastatin44 49 59 28 1114.0PTHLH, HMGCR, CDKN1B
16vitamin d449.9MEN1, ACPP, PTHLH, LGALS3, CP
17fibrinogen449.9IL6R, KRT19, LGALS3, CP
18epinephrine44 11 2411.9CP, HMGCR, RAP1B, RAPGEF3
19ribonucleic acid449.9RET, IL6R, KRT19, PTHLH
20glutamine449.9CDKN1B, IL6R, RAP1A, LGALS3, CP
21wortmannin449.9CDKN1B, RET, IL6R, RAP1B, LGALS3
22cisplatin44 49 59 1112.8CDKN1B, KRT19, ACPP, PTHLH, LGALS3
23thymidine44 2410.8MEN1, CDKN1B, IL6R, KRT19, ACPP, PTHLH
2412-o-tetradecanoylphorbol 13-acetate449.8CDKN1B, RET, IL6R, RAP1A, PTHLH
25cholesterol44 28 11 2412.7DPP4, CDKN1B, IL6R, HMGCR, ACPP, CP
26glucose449.7CDKN1B, IL6R, RAPGEF3, KRT19, PTHLH
27tartrate449.7PTHLH, ACPP
28aspartate449.7DPP4, RET, KRT19, ACPP, CP
29adenylate449.7DPP4, RAP1A, RAPGEF3, PTHLH, CP
30lactate449.6DPP4, HMGCR, KRT19, ACPP, PTHLH, LGALS3
31creatinine449.6DPP4, IL6R, HMGCR, KRT19, ACPP, PTHLH
32progesterone44 59 28 11 2413.6S100A4, CDKN1B, IL6R, KRT19, ACPP, PTHLH
33oligonucleotide449.5LGALS3, ACPP, IL6R, RET, CDKN1B, S100A4
34oxygen44 2410.5CDKN1B, RAP1A, KRT19, PTHLH, LGALS3, CP
35threonine449.5LGALS3, PTHLH, RAP1A, RET, MCM2, CDKN1B
36ly294002449.5RAP1B, RAP1A, RET, CDKN1B
37testosterone44 59 11 2412.5CDKN1B, RET, IL6R, KRT19, ACPP, PTHLH
38atp44 2810.5DPP4, CDKN1B, RET, KRT19, ACPP, PTHLH
39paraffin449.5CDKN1B, MCM2, RET, KRT19, ACPP, PTHLH
40cyclic amp44 2410.4CDKN1B, RET, RAP1A, RAPGEF3, RAP1B, PTHLH
41agar449.4CDKN1B, RET, RAP1A, ACPP, PTHLH, LGALS3
42alanine449.3DPP4, CDKN1B, MCM2, RET, ACPP, PTHLH
43retinoic acid44 2410.2S100A4, DPP4, CDKN1B, RET, IL6R, KRT19
44serine449.2CSNK1G2, MEN1, CDKN1B, MCM2, RET, HMGCR
45phosphatidylinositol449.2CDKN1B, RET, IL6R, RAP1A, RAPGEF3, RAP1B
46lipid449.1RET, IL6R, RAP1A, HMGCR, ACPP, PTHLH
47arginine449.0CDKN1B, RET, IL6R, RAP1A, HMGCR, ACPP
48vegf448.7CP, MEN1, CDKN1B, RET, IL6R, RAP1A
49calcium44 49 11 2411.5S100A4, MEN1, DPP4, RET, IL6R, RAP1A
50tyrosine448.2MCM7, CDKN1B, DPP4, MEN1, S100A4, RET

GO Terms for genes affiliated with Follicular Adenoma

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16Gene Ontology
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Cellular components related to Follicular Adenoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MCM complexGO:04255510.0MCM7, MCM2
2chromatinGO:0007859.6MCM7, MCM2, MEN1

Biological processes related to Follicular Adenoma according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1DNA unwinding involved in DNA replicationGO:00626810.0MCM2, MCM7
2regulation of cell junction assemblyGO:190188810.0RAP1B, RAP1A
3positive regulation of Rap GTPase activityGO:03285410.0RAPGEF3, RAP1A
4establishment of endothelial barrierGO:0610289.9RAP1B, RAPGEF3, RAP1A
5Rap protein signal transductionGO:0324869.8RAP1B, RAPGEF3, RAP1A
6cellular response to cAMPGO:0713209.8RAP1A, RAPGEF3, RAP1B
7energy reserve metabolic processGO:0061129.7RAP1B, RAPGEF3, RAP1A
8regulation of insulin secretionGO:0507969.4RAP1A, RAPGEF3, RAP1B
9small molecule metabolic processGO:0442818.7CSNK1G2, RAP1A, RAPGEF3, RAP1B, HMGCR, SLC25A32

Molecular functions related to Follicular Adenoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Rap guanyl-nucleotide exchange factor activityGO:0170349.9RAPGEF3, RAP1A
2protein bindingGO:0055157.3LGALS3, S100A4, MEN1, DPP4, CDKN1B, MCM2

Products for genes affiliated with Follicular Adenoma

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Sources for Follicular Adenoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
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57SNOMED-CT via Orphanet
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