MCID: FLL031
MIFTS: 39

Follicular Adenoma malady

Endocrine diseases category

Aliases & Classifications for Follicular Adenoma

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Follicular Adenoma, Aliases & Descriptions:

Name: Follicular Adenoma 9 11 60
Follicular Adenoma of the Thyroid Gland 9
Thyroid Gland Follicular Adenoma 60
 
Thyroid Follicular Adenoma 9
Adenoma Follicular 43


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Endocrine diseases


External Ids:

Disease Ontology9 DOID:6204
SNOMED-CT55 55021007
MeSH33 D000236

Summaries for Follicular Adenoma

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MalaCards based summary: Follicular Adenoma, also known as follicular adenoma of the thyroid gland, is related to adenoma and goiter. An important gene associated with Follicular Adenoma is LGALS3 (lectin, galactoside-binding, soluble, 3), and among its related pathways is Spinal Cord Injury. The compounds amide and eb 1089 have been mentioned in the context of this disorder. Affiliated tissues include thyroid, bone and colon, and related mouse phenotypes are renal/urinary system and respiratory system.

Related Diseases for Follicular Adenoma

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Diseases related to Follicular Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 72)
idRelated DiseaseScoreTop Affiliating Genes
1adenoma31.1RET, LGALS3, CDKN1B, MEN1
2goiter30.6RET, LGALS3
3papillary carcinoma30.4CDKN1B, RET, LGALS3, DPP4
4thyroid adenoma30.2LGALS3, RET
5hemangioma30.1RET, MEN1
6colon adenocarcinoma30.1DPP4, LGALS3, CDKN1B
7primary hyperparathyroidism30.1MEN1, PTHLH, RET
8thyroid carcinoma, follicular29.9DPP4, RET, LGALS3
9thyroid cancer29.9CDKN1B, LGALS3, RET
10hyperparathyroidism29.7RET, MEN1, CDKN1B, PTHLH
11parathyroid adenoma29.6LGALS3, MEN1, RET, PTHLH, CDKN1B
12adenocarcinoma29.4LGALS3, DPP4, MEN1, CDKN1B, PTHLH
13thyroiditis11.0
14atypical follicular adenoma10.4
15carney complex variant10.2MEN1, CDKN1B
16multiple endocrine neoplasia 110.2CDKN1B, MEN1
17tongue squamous cell carcinoma10.2PTHLH, LGALS3
18follicular lymphoma10.2LGALS3, CDKN1B
19secondary hyperparathyroidism of renal origin10.1MEN1, PTHLH
20cholangiocarcinoma10.1LGALS3, CDKN1B
21prolactinoma10.1PTHLH, MEN1
22hypercalcemia10.1MEN1, PTHLH
23nodular goiter10.1RET, LGALS3
24thyroid carcinoma, papillary10.1LGALS3, RET
25hyperparathyroidism-jaw tumor syndrome10.1RET, MEN1
26parathyroid carcinoma10.1RET, MEN1
27multiple endocrine neoplasia iia10.1RET, MEN1
28von hippel-lindau syndrome10.1MEN1, RET
29hashimoto thyroiditis10.1RET, LGALS3
30acute lymphoblastic leukemia, childhood10.1CDKN1B, PTHLH
31gastrointestinal stromal tumor10.1
32pheochromocytoma10.1
33renal cell carcinoma10.1
34acromegaly10.1
35oxyphilic adenoma10.1
36cowden disease10.1
37multinodular goiter10.1
38astrocytoma10.1
39cystic teratoma10.1
40mediastinitis10.1
41papilloma10.1
42hemangioendothelioma10.1
43kikuchi disease10.1
44teratoma10.1
45riedel thyroiditis10.1
46neurofibromatosis10.0MEN1, RET
47pituitary tumors10.0LGALS3, MEN1, CDKN1B
48paraganglioma10.0MEN1, RET
49reticulosarcoma10.0CDKN1B, DPP4, LGALS3
50cushing's syndrome10.0RET, MEN1

Graphical network of the top 20 diseases related to Follicular Adenoma:



Diseases related to follicular adenoma

Symptoms for Follicular Adenoma

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Drugs & Therapeutics for Follicular Adenoma

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Drug clinical trials:

Search ClinicalTrials for Follicular Adenoma

Search NIH Clinical Center for Follicular Adenoma

Genetic Tests for Follicular Adenoma

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Anatomical Context for Follicular Adenoma

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MalaCards organs/tissues related to Follicular Adenoma:

31
Thyroid, Bone, Colon, Breast

Animal Models for Follicular Adenoma or affiliated genes

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Publications for Follicular Adenoma

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Articles related to Follicular Adenoma:

(show top 50)    (show all 106)
idTitleAuthorsYear
1
Meningioma like tumour of thyroid: a rare variant of follicular adenoma. (24640816)
2014
2
Better understanding in the differentiation of thyroid follicular adenoma, follicular carcinoma, and follicular variant of papillary carcinoma: a retrospective study. (25309594)
2014
3
How should a follicular adenoma with papillary architecture be classified on thyroid FNA? Case report with histological correlation. (25073478)
2014
4
Unusual association of primary hyperparathyroidism, papillary thyroid carcinoma, and follicular adenoma in a young female. (23776923)
2013
5
Thyroid Follicular Adenoma with Accumulation of Collagen Type IV in a Common Marmoset (Callithrix jacchus). (24060155)
2013
6
Follicular adenoma with extensive extracellular mucin deposition: report on two cases. (23236259)
2012
7
Examination of CD26/DPPIV, p53, and PTEN expression in thyroid follicular adenoma. (22086610)
2012
8
Comparison of proliferating cell nuclear antigen, thyroid transcription factor-1, Ki-67, p63, p53 and high-molecular weight cytokeratin expressions in papillary thyroid carcinoma, follicular carcinoma, and follicular adenoma. (21315633)
2011
9
Thyroid follicular adenoma composed of lipid-rich cells. (21165779)
2011
10
Kikuchi disease and thyroid follicular adenoma. (20859864)
2010
11
Expression of the sonic hedgehog pathway molecules in synchronous follicular adenoma and papillary carcinoma of the thyroid gland in predicting malignancy. (20797751)
2010
12
Clear cell follicular adenoma of the thyroid--a challenge in intra-operative diagnostics. (19235130)
2010
13
Synchronous occurrence of anaplastic, follicular and papillary carcinomas with follicular adenoma in thyroid gland. (20551551)
2010
14
Thyroid follicular adenoma producing parathyroid hormone-related protein with a normal serum calcium level. (19915296)
2009
15
Identification and functional characterization of two novel activating thyrotropin receptor mutants in toxic thyroid follicular adenomas. (19499991)
2009
16
Are there any specific ultrasound findings of nodular hyperplasia ("leave me alone" lesion) to differentiate it from follicular adenoma? (19241229)
2009
17
Correspondence between ultrasonography and histological features in a single thyroid nodule with coexisting follicular adenoma and papillary carcinoma. (18631017)
2008
18
Immunohistochemical analysis of survivin expression in thyroid follicular adenoma and carcinoma. (17122639)
2006
19
Human galectin-3 immunoexpression in thyroid follicular adenomas with cell atypia. (15887854)
2005
20
Diagnostic applicability of dipeptidyl aminopeptidase IV activity in cytological samples for differentiating follicular thyroid carcinoma from follicular adenoma. (14718282)
2004
21
Signet-ring follicular adenoma of the thyroid diagnosed by fine needle aspiration. Report of a case with cytologic description. (14969188)
2004
22
Ectopic thyroid tissue with follicular adenoma mimicking carotid body tumor. (15577811)
2004
23
Is atypical follicular adenoma of the thyroid a preinvasive malignancy? (12874762)
2003
24
Distinctive expression of STAT3 in papillary thyroid carcinomas and a subset of follicular adenomas. (12647789)
2003
25
Usefulness of galectin-3 immunohistochemistry in differential diagnosis between thyroid follicular carcinoma and follicular adenoma. (14575419)
2003
26
Tumor-to-tumor metastases to follicular adenoma of thyroid: case report and review of the literature. (17159402)
2002
27
Large-needle aspiration biopsy for the preoperative selection of follicular adenoma diagnosed by fine-needle aspiration as a microfollicular nodule or suspected cancer. (11943905)
2002
28
Mutation analysis of the Epac--Rap1 signaling pathway in cold thyroid follicular adenomas. (11375794)
2001
29
Follicular adenoma of the thyroid gland with extensive bone metaplasia. (11718227)
2001
30
Follicular adenoma of thyroid associated with mediastinal malignant hemangioendothelioma, masquerading as malignant retrosternal goiter. (11573559)
2001
31
The role of frozen section, gender, age, and tumor size in the differentiation of follicular adenoma from carcinoma: a meta-analysis. (11114645)
2000
32
Development of thyroid follicular adenoma on simvastatin therapy. (10846948)
2000
33
Nuclear area measurements of parathyroid adenoma, parathyroid hyperplasia and thyroid follicular adenoma. A comparison. (9051185)
1997
34
Clear cell follicular adenoma of the thyroid: a case report. (8872434)
1996
35
Follicular adenoma of the thyroid gland in children. (8555125)
1995
36
Differentiation of follicular adenoma and carcinoma of thyroid by immunohistochemical demonstration of ceruloplasmin. (7959983)
1994
37
Carcinomas metastatic to follicular adenomas of the thyroid gland. Report of two cases. (7514864)
1994
38
Translocation t(5;19): a recurrent change in thyroid follicular adenoma. (1377944)
1992
39
Estrogen-receptor protein in thyroid neoplasms. An immunohistochemical analysis of papillary carcinoma, follicular carcinoma, and follicular adenoma. (1768209)
1991
40
Karyometric marker features in fine needle aspirates of follicular adenoma of the thyroid. (2206191)
1990
41
Discrimination between follicular adenoma and follicular carcinoma of the thyroid: preoperative validity of cytometry on aspiration smears. (2640896)
1989
42
CT of follicular adenoma in the thyroid gland. (3628854)
1987
43
Spontaneous thyroid follicular adenoma in a laboratory mouse (Mus musculus). (3803433)
1986
44
Follicular adenoma of the thyroid with intranuclear vacuoles and clear nuclei. A case report. (6592921)
1984
45
Radionuclide demonstration of acute hemorrhage into follicular adenoma of the thyroid. (6299640)
1983
46
Immunoelectron microscopic localization of thyroglobulin in human follicular adenoma. (6367352)
1983
47
A follicular adenoma arising from the thyroid tissue of a benign cystic teratoma during pregnancy--lightmicroscopical, ultrastructural and endocrinological studies. (7240873)
1980
48
Thyroglobulin and other soluble thyroid iodoproteins in papillary carcinoma and follicular adenoma: properties and biosynthesis in vitro. (6778691)
1980
49
Planimetric studies on fine needle aspirates from follicular adenoma and follicular carcinoma of the thyroid. (6989141)
1980
50
Clinical implications of the rare thyroid carcinoma which is indistinguishable from a follicular adenoma. (727220)
1978

Variations for Follicular Adenoma

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Expression for genes affiliated with Follicular Adenoma

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Search GEO for disease gene expression data for Follicular Adenoma.

Pathways for genes affiliated with Follicular Adenoma

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Pathways related to Follicular Adenoma according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5CDKN1B, LGALS3

Compounds for genes affiliated with Follicular Adenoma

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Compounds related to Follicular Adenoma according to GeneCards Suite gene sharing:

(show all 43)
idCompoundScoreTop Affiliating Genes
1amide439.8DPP4, LGALS3
2eb 108943 5910.7CDKN1B, PTHLH
3hydroxyproline43 24 1211.6DPP4, PTHLH
4ag 1478439.6CDKN1B, PTHLH
5dbc-amp439.5CDKN1B, PTHLH
6sodium dodecylsulfate439.5LGALS3, PTHLH
7lovastatin43 49 59 28 1213.4CDKN1B, PTHLH
8succinate439.4DPP4, RET
9vitamin d439.3PTHLH, MEN1, LGALS3
101,25 dihydroxy vitamin d3439.3PTHLH, CDKN1B
11leptomycin b43 5910.3CDKN1B, LGALS3, PTHLH
12troglitazone43 28 59 1212.3CDKN1B, PTHLH
13matrigel439.3PTHLH, LGALS3, DPP4
14lactate439.3DPP4, LGALS3, PTHLH
15cisplatin43 49 59 1212.2CDKN1B, LGALS3, PTHLH
16thymidine43 2410.2PTHLH, MEN1, CDKN1B
17progesterone43 28 59 24 1213.2PTHLH, LGALS3, CDKN1B
18cycloheximide439.1CDKN1B, DPP4, PTHLH
19wortmannin439.1RET, LGALS3, CDKN1B
20rosiglitazone28 43 49 24 1213.0DPP4, PTHLH
21glutamate438.9CDKN1B, DPP4, LGALS3
22valine438.9DPP4, RET, PTHLH
23oligonucleotide438.9CDKN1B, LGALS3, RET
2412-o-tetradecanoylphorbol 13-acetate438.9CDKN1B, RET, PTHLH
25estrogen438.8CDKN1B, LGALS3, MEN1, PTHLH
26glycogen43 249.8PTHLH, LGALS3, DPP4, CDKN1B
27cyclic amp43 249.8PTHLH, RET, CDKN1B
28heparin43 28 24 1211.8CDKN1B, DPP4, LGALS3, PTHLH
29nitric oxide43 24 1210.8CDKN1B, DPP4, LGALS3, PTHLH
30testosterone43 59 24 1211.7PTHLH, RET, CDKN1B
31butyrate438.6RET, LGALS3, DPP4, CDKN1B
32agar438.5PTHLH, RET, LGALS3, CDKN1B
33paraffin438.5PTHLH, RET, LGALS3, CDKN1B
34arginine438.5PTHLH, RET, LGALS3, CDKN1B
35phosphatidylinositol438.5PTHLH, RET, LGALS3, CDKN1B
36threonine438.5PTHLH, RET, LGALS3, CDKN1B
37vegf438.1PTHLH, RET, MEN1, LGALS3, CDKN1B
38calcium43 49 24 1211.0DPP4, LGALS3, MEN1, RET, PTHLH
39alanine438.0CDKN1B, DPP4, LGALS3, RET, PTHLH
40retinoic acid43 249.0CDKN1B, DPP4, LGALS3, RET, PTHLH
41atp43 289.0PTHLH, RET, LGALS3, DPP4, CDKN1B
42serine437.6CDKN1B, DPP4, LGALS3, MEN1, RET, PTHLH
43tyrosine437.6PTHLH, RET, MEN1, LGALS3, DPP4, CDKN1B

GO Terms for genes affiliated with Follicular Adenoma

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Biological processes related to Follicular Adenoma according to GeneCards Suite gene sharing:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of cyclin-dependent protein serine/threonine kinase activityGO:00457369.7CDKN1B, MEN1
2osteoblast developmentGO:00020769.6MEN1, PTHLH
3epithelial cell differentiationGO:00308559.5LGALS3, PTHLH
4negative regulation of sequence-specific DNA binding transcription factor activityGO:00434339.5PTHLH, MEN1
5cell cycle arrestGO:00070509.5CDKN1B, MEN1
6MAPK cascadeGO:00001659.2MEN1, RET
7skeletal system developmentGO:00015019.1LGALS3, PTHLH
8negative regulation of cell proliferationGO:00082859.1PTHLH, MEN1, CDKN1B
9activation of cysteine-type endopeptidase activity involved in apoptotic processGO:00069199.0RET, CDKN1B
10positive regulation of cell proliferationGO:00082849.0CDKN1B, DPP4, PTHLH

Products for genes affiliated with Follicular Adenoma

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Sources for Follicular Adenoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet