MCID: FLL031
MIFTS: 48

Follicular Adenoma malady

Cancer diseases, Endocrine diseases categories
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Summaries for Follicular Adenoma

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Wikipedia:65 A thyroid adenoma is a benign tumor of the thyroid gland. more...

MalaCards based summary: Follicular Adenoma, also known as follicular adenoma of the thyroid gland, is related to adenoma and papillary thyroid carcinoma. An important gene associated with Follicular Adenoma is LGALS3 (lectin, galactoside-binding, soluble, 3), and among its related pathways is Spinal Cord Injury. The compounds amide and eb 1089 have been mentioned in the context of this disorder. Affiliated tissues include thyroid, bone and colon, and related mouse phenotypes are renal/urinary system and respiratory system.

Aliases & Classifications for Follicular Adenoma

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Follicular Adenoma, Aliases & Descriptions:

Name: Follicular Adenoma 8 10 62
Follicular Adenoma of the Thyroid Gland 8 62
 
Thyroid Follicular Adenoma 8 62
Adenoma Follicular 44


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Endocrine diseases


External Ids:

Disease Ontology8 DOID:6204
SNOMED-CT57 55021007
MeSH34 D000236

Related Diseases for Follicular Adenoma

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Diseases related to Follicular Adenoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 76)
idRelated DiseaseScoreTop Affiliating Genes
1adenoma31.1CDKN1B, LGALS3, MEN1, RET
2papillary thyroid carcinoma30.8LGALS3, RET
3goiter30.6RET, LGALS3
4papillary carcinoma30.5RET, LGALS3, DPP4, CDKN1B
5thyroid adenoma30.2LGALS3, RET
6follicular thyroid carcinoma30.2RET, LGALS3, DPP4
7hemangioma30.1RET, MEN1
8colon adenocarcinoma30.1LGALS3, DPP4, CDKN1B
9primary hyperparathyroidism30.1PTHLH, RET, MEN1
10hyperparathyroidism29.7PTHLH, RET, MEN1, CDKN1B
11parathyroid adenoma29.6CDKN1B, LGALS3, MEN1, RET, PTHLH
12adenocarcinoma29.4PTHLH, MEN1, LGALS3, DPP4, CDKN1B
13thyroiditis11.0
14atypical follicular adenoma10.4
15meningioma10.3
16carney complex10.2MEN1, CDKN1B
17wermer syndrome10.2CDKN1B, MEN1
18tongue squamous cell carcinoma10.2LGALS3, PTHLH
19follicular lymphoma10.2CDKN1B, LGALS3
20secondary hyperparathyroidism of renal origin10.2PTHLH, MEN1
21prolactinoma10.1PTHLH, MEN1
22cholangiocarcinoma10.1CDKN1B, LGALS3
23hypercalcemia10.1MEN1, PTHLH
24nodular goiter10.1LGALS3, RET
25hyperparathyroidism-jaw tumor syndrome10.1MEN1, RET
26parathyroid carcinoma10.1MEN1, RET
27familial colorectal cancer10.1MEN1, RET
28multiple endocrine neoplasia type 2a10.1MEN1, RET
29von hippel-lindau disease10.1MEN1, RET
30autoimmune thyroiditis10.1LGALS3, RET
31acute lymphoblastic leukemia, childhood10.1CDKN1B, PTHLH
32neurofibromatosis10.1MEN1, RET
33renal cell carcinoma10.1
34acromegaly10.1
35cowden disease10.1
36gastrointestinal stromal tumor10.1
37oxyphilic adenoma10.1
38multinodular goiter10.1
39astrocytoma10.1
40cystic teratoma10.1
41mediastinitis10.1
42papilloma10.1
43thyroid cancer10.1
44pheochromocytoma10.1
45carotid body tumor10.1
46hemangioendothelioma10.1
47kikuchi disease10.1
48teratoma10.1
49riedel thyroiditis10.1
50pituitary tumors10.1MEN1, LGALS3, CDKN1B

Graphical network of the top 20 diseases related to Follicular Adenoma:



Diseases related to follicular adenoma

Symptoms for Follicular Adenoma

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Drugs & Therapeutics for Follicular Adenoma

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Drug clinical trials:

Search ClinicalTrials for Follicular Adenoma

Search NIH Clinical Center for Follicular Adenoma

Genetic Tests for Follicular Adenoma

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Anatomical Context for Follicular Adenoma

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MalaCards organs/tissues related to Follicular Adenoma:

32
Thyroid, Bone, Colon, Breast

Animal Models for Follicular Adenoma or affiliated genes

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Publications for Follicular Adenoma

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Articles related to Follicular Adenoma:

(show top 50)    (show all 104)
idTitleAuthorsYear
1
Meningioma like tumour of thyroid: a rare variant of follicular adenoma. (24640816)
2014
2
Better understanding in the differentiation of thyroid follicular adenoma, follicular carcinoma, and follicular variant of papillary carcinoma: a retrospective study. (25309594)
2014
3
How should a follicular adenoma with papillary architecture be classified on thyroid FNA? Case report with histological correlation. (25073478)
2014
4
Unusual association of primary hyperparathyroidism, papillary thyroid carcinoma, and follicular adenoma in a young female. (23776923)
2013
5
Thyroid Follicular Adenoma with Accumulation of Collagen Type IV in a Common Marmoset (Callithrix jacchus). (24060155)
2013
6
Follicular adenoma with extensive extracellular mucin deposition: report on two cases. (23236259)
2012
7
Examination of CD26/DPPIV, p53, and PTEN expression in thyroid follicular adenoma. (22086610)
2012
8
Comparison of proliferating cell nuclear antigen, thyroid transcription factor-1, Ki-67, p63, p53 and high-molecular weight cytokeratin expressions in papillary thyroid carcinoma, follicular carcinoma, and follicular adenoma. (21315633)
2011
9
Thyroid follicular adenoma composed of lipid-rich cells. (21165779)
2011
10
Kikuchi disease and thyroid follicular adenoma. (20859864)
2010
11
Expression of the sonic hedgehog pathway molecules in synchronous follicular adenoma and papillary carcinoma of the thyroid gland in predicting malignancy. (20797751)
2010
12
Clear cell follicular adenoma of the thyroid--a challenge in intra-operative diagnostics. (19235130)
2010
13
Synchronous occurrence of anaplastic, follicular and papillary carcinomas with follicular adenoma in thyroid gland. (20551551)
2010
14
Thyroid follicular adenoma producing parathyroid hormone-related protein with a normal serum calcium level. (19915296)
2009
15
Identification and functional characterization of two novel activating thyrotropin receptor mutants in toxic thyroid follicular adenomas. (19499991)
2009
16
Are there any specific ultrasound findings of nodular hyperplasia ("leave me alone" lesion) to differentiate it from follicular adenoma? (19241229)
2009
17
Correspondence between ultrasonography and histological features in a single thyroid nodule with coexisting follicular adenoma and papillary carcinoma. (18631017)
2008
18
Immunohistochemical analysis of survivin expression in thyroid follicular adenoma and carcinoma. (17122639)
2006
19
Human galectin-3 immunoexpression in thyroid follicular adenomas with cell atypia. (15887854)
2005
20
Diagnostic applicability of dipeptidyl aminopeptidase IV activity in cytological samples for differentiating follicular thyroid carcinoma from follicular adenoma. (14718282)
2004
21
Signet-ring follicular adenoma of the thyroid diagnosed by fine needle aspiration. Report of a case with cytologic description. (14969188)
2004
22
Ectopic thyroid tissue with follicular adenoma mimicking carotid body tumor. (15577811)
2004
23
Is atypical follicular adenoma of the thyroid a preinvasive malignancy? (12874762)
2003
24
Distinctive expression of STAT3 in papillary thyroid carcinomas and a subset of follicular adenomas. (12647789)
2003
25
Usefulness of galectin-3 immunohistochemistry in differential diagnosis between thyroid follicular carcinoma and follicular adenoma. (14575419)
2003
26
Tumor-to-tumor metastases to follicular adenoma of thyroid: case report and review of the literature. (17159402)
2002
27
Large-needle aspiration biopsy for the preoperative selection of follicular adenoma diagnosed by fine-needle aspiration as a microfollicular nodule or suspected cancer. (11943905)
2002
28
Mutation analysis of the Epac--Rap1 signaling pathway in cold thyroid follicular adenomas. (11375794)
2001
29
Follicular adenoma of the thyroid gland with extensive bone metaplasia. (11718227)
2001
30
Follicular adenoma of thyroid associated with mediastinal malignant hemangioendothelioma, masquerading as malignant retrosternal goiter. (11573559)
2001
31
The role of frozen section, gender, age, and tumor size in the differentiation of follicular adenoma from carcinoma: a meta-analysis. (11114645)
2000
32
Development of thyroid follicular adenoma on simvastatin therapy. (10846948)
2000
33
Nuclear area measurements of parathyroid adenoma, parathyroid hyperplasia and thyroid follicular adenoma. A comparison. (9051185)
1997
34
Clear cell follicular adenoma of the thyroid: a case report. (8872434)
1996
35
Follicular adenoma of the thyroid gland in children. (8555125)
1995
36
Differentiation of follicular adenoma and carcinoma of thyroid by immunohistochemical demonstration of ceruloplasmin. (7959983)
1994
37
Carcinomas metastatic to follicular adenomas of the thyroid gland. Report of two cases. (7514864)
1994
38
Translocation t(5;19): a recurrent change in thyroid follicular adenoma. (1377944)
1992
39
Estrogen-receptor protein in thyroid neoplasms. An immunohistochemical analysis of papillary carcinoma, follicular carcinoma, and follicular adenoma. (1768209)
1991
40
Karyometric marker features in fine needle aspirates of follicular adenoma of the thyroid. (2206191)
1990
41
Discrimination between follicular adenoma and follicular carcinoma of the thyroid: preoperative validity of cytometry on aspiration smears. (2640896)
1989
42
CT of follicular adenoma in the thyroid gland. (3628854)
1987
43
Spontaneous thyroid follicular adenoma in a laboratory mouse (Mus musculus). (3803433)
1986
44
Follicular adenoma of the thyroid with intranuclear vacuoles and clear nuclei. A case report. (6592921)
1984
45
Radionuclide demonstration of acute hemorrhage into follicular adenoma of the thyroid. (6299640)
1983
46
Immunoelectron microscopic localization of thyroglobulin in human follicular adenoma. (6367352)
1983
47
A follicular adenoma arising from the thyroid tissue of a benign cystic teratoma during pregnancy--lightmicroscopical, ultrastructural and endocrinological studies. (7240873)
1980
48
Thyroglobulin and other soluble thyroid iodoproteins in papillary carcinoma and follicular adenoma: properties and biosynthesis in vitro. (6778691)
1980
49
Planimetric studies on fine needle aspirates from follicular adenoma and follicular carcinoma of the thyroid. (6989141)
1980
50
Clinical implications of the rare thyroid carcinoma which is indistinguishable from a follicular adenoma. (727220)
1978

Variations for Follicular Adenoma

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Expression for genes affiliated with Follicular Adenoma

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Expression patterns in normal tissues for genes affiliated with Follicular Adenoma

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Pathways for genes affiliated with Follicular Adenoma

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Pathways related to Follicular Adenoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5CDKN1B, LGALS3

Compounds for genes affiliated with Follicular Adenoma

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Compounds related to Follicular Adenoma according to GeneCards/GeneDecks:

(show all 43)
idCompoundScoreTop Affiliating Genes
1amide449.8DPP4, LGALS3
2eb 108944 6110.7CDKN1B, PTHLH
3hydroxyproline44 24 1111.6DPP4, PTHLH
4ag 1478449.6CDKN1B, PTHLH
5dbc-amp449.5CDKN1B, PTHLH
6sodium dodecylsulfate449.5LGALS3, PTHLH
7lovastatin44 50 61 28 1113.4CDKN1B, PTHLH
8succinate449.4DPP4, RET
9vitamin d449.3PTHLH, MEN1, LGALS3
101,25 dihydroxy vitamin d3449.3PTHLH, CDKN1B
11leptomycin b44 6110.3CDKN1B, LGALS3, PTHLH
12troglitazone44 28 61 1112.3CDKN1B, PTHLH
13matrigel449.3PTHLH, LGALS3, DPP4
14lactate449.3DPP4, LGALS3, PTHLH
15cisplatin44 50 61 1112.2CDKN1B, LGALS3, PTHLH
16thymidine44 2410.2PTHLH, MEN1, CDKN1B
17progesterone44 28 61 24 1113.2PTHLH, LGALS3, CDKN1B
18cycloheximide449.1CDKN1B, DPP4, PTHLH
19wortmannin449.1RET, LGALS3, CDKN1B
20rosiglitazone28 44 50 24 1113.0DPP4, PTHLH
21glutamate448.9CDKN1B, DPP4, LGALS3
22valine448.9DPP4, RET, PTHLH
23oligonucleotide448.9CDKN1B, LGALS3, RET
2412-o-tetradecanoylphorbol 13-acetate448.9CDKN1B, RET, PTHLH
25estrogen448.8CDKN1B, LGALS3, MEN1, PTHLH
26glycogen44 249.8PTHLH, LGALS3, DPP4, CDKN1B
27cyclic amp44 249.8PTHLH, RET, CDKN1B
28heparin44 28 24 1111.8CDKN1B, DPP4, LGALS3, PTHLH
29nitric oxide44 24 1110.8CDKN1B, DPP4, LGALS3, PTHLH
30testosterone44 61 24 1111.7PTHLH, RET, CDKN1B
31butyrate448.6RET, LGALS3, DPP4, CDKN1B
32agar448.5PTHLH, RET, LGALS3, CDKN1B
33paraffin448.5PTHLH, RET, LGALS3, CDKN1B
34arginine448.5PTHLH, RET, LGALS3, CDKN1B
35phosphatidylinositol448.5PTHLH, RET, LGALS3, CDKN1B
36threonine448.5PTHLH, RET, LGALS3, CDKN1B
37vegf448.1PTHLH, RET, MEN1, LGALS3, CDKN1B
38calcium44 50 24 1111.0DPP4, LGALS3, MEN1, RET, PTHLH
39alanine448.0CDKN1B, DPP4, LGALS3, RET, PTHLH
40retinoic acid44 249.0CDKN1B, DPP4, LGALS3, RET, PTHLH
41atp44 289.0PTHLH, RET, LGALS3, DPP4, CDKN1B
42serine447.6CDKN1B, DPP4, LGALS3, MEN1, RET, PTHLH
43tyrosine447.6PTHLH, RET, MEN1, LGALS3, DPP4, CDKN1B

GO Terms for genes affiliated with Follicular Adenoma

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Biological processes related to Follicular Adenoma according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of cyclin-dependent protein serine/threonine kinase activityGO:0457369.7CDKN1B, MEN1
2osteoblast developmentGO:0020769.6MEN1, PTHLH
3epithelial cell differentiationGO:0308559.5LGALS3, PTHLH
4negative regulation of sequence-specific DNA binding transcription factor activityGO:0434339.5PTHLH, MEN1
5cell cycle arrestGO:0070509.5CDKN1B, MEN1
6MAPK cascadeGO:0001659.2MEN1, RET
7skeletal system developmentGO:0015019.1LGALS3, PTHLH
8negative regulation of cell proliferationGO:0082859.1PTHLH, MEN1, CDKN1B
9activation of cysteine-type endopeptidase activity involved in apoptotic processGO:0069199.0RET, CDKN1B
10positive regulation of cell proliferationGO:0082849.0CDKN1B, DPP4, PTHLH

Products for genes affiliated with Follicular Adenoma

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Sources for Follicular Adenoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet