MCID: FLL031
MIFTS: 47

Follicular Adenoma malady

Cancer diseases, Endocrine diseases categories
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Summaries for Follicular Adenoma

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65Wikipedia, 33MalaCards
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Wikipedia:65 A thyroid adenoma is a benign tumor of the thyroid gland. more...

MalaCards: Follicular Adenoma, also known as follicular adenoma of the thyroid gland, is related to adenoma and papillary carcinoma. An important gene associated with Follicular Adenoma is LGALS3 (lectin, galactoside-binding, soluble, 3), and among its related pathways is Spinal Cord Injury. The compounds amide and eb 1089 have been mentioned in the context of this disorder. Affiliated tissues include thyroid, bone and colon, and related mouse phenotypes are renal/urinary system and respiratory system.

Aliases & Classifications for Follicular Adenoma

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8Disease Ontology, 10DISEASES, 45Novoseek, 62UMLS, 35MeSH, 58SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Endocrine diseases


Aliases & Descriptions:

follicular adenoma 8 10 62
follicular adenoma of the thyroid gland 8
thyroid follicular adenoma 8
adenoma follicular 45


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Disease Ontology8 DOID:6204
SNOMED-CT58 55021007
MeSH35 D000236

Related Diseases for Follicular Adenoma

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17GeneCards, 18GeneDecks
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Diseases related to Follicular Adenoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 74)
idRelated DiseaseScoreTop Affiliating Genes
1adenoma31.4CDKN1B, LGALS3, MEN1, RET
2papillary carcinoma30.8RET, LGALS3, DPP4, CDKN1B
3papillary thyroid carcinoma30.7LGALS3, RET
4goiter30.3RET, LGALS3
5follicular thyroid carcinoma30.2RET, LGALS3, DPP4
6primary hyperparathyroidism30.2PTHLH, RET, MEN1
7parathyroid adenoma30.2CDKN1B, LGALS3, MEN1, RET, PTHLH
8hyperparathyroidism30.1PTHLH, RET, MEN1, CDKN1B
9thyroid adenoma30.1LGALS3, RET
10hemangioma30.1RET, MEN1
11colon adenocarcinoma30.1LGALS3, DPP4, CDKN1B
12thyroid cancer30.0RET, LGALS3, CDKN1B
13adenocarcinoma29.9PTHLH, MEN1, LGALS3, DPP4, CDKN1B
14thyroiditis11.0
15atypical follicular adenoma10.3
16meningioma10.2
17carney complex10.0MEN1, CDKN1B
18wermer syndrome10.0CDKN1B, MEN1
19acromegaly10.0
20gastrointestinal stromal tumor10.0
21oxyphilic adenoma10.0
22cowden disease10.0
23astrocytoma10.0
24cystic teratoma10.0
25mediastinitis10.0
26papilloma10.0
27renal cell carcinoma10.0
28pheochromocytoma10.0
29carotid body tumor10.0
30hemangioendothelioma10.0
31kikuchi disease10.0
32teratoma10.0
33tongue squamous cell carcinoma10.0LGALS3, PTHLH
34follicular lymphoma10.0CDKN1B, LGALS3
35secondary hyperparathyroidism of renal origin10.0PTHLH, MEN1
36prolactinoma10.0PTHLH, MEN1
37cholangiocarcinoma10.0CDKN1B, LGALS3
38hypercalcemia10.0MEN1, PTHLH
39nodular goiter10.0LGALS3, RET
40hyperparathyroidism-jaw tumor syndrome10.0MEN1, RET
41parathyroid carcinoma10.0MEN1, RET
42familial colorectal cancer10.0MEN1, RET
43multiple endocrine neoplasia type 2a10.0MEN1, RET
44von hippel-lindau disease10.0MEN1, RET
45autoimmune thyroiditis10.0LGALS3, RET
46acute lymphoblastic leukemia, childhood10.0CDKN1B, PTHLH
47neurofibromatosis10.0MEN1, RET
48pituitary tumors10.0MEN1, LGALS3, CDKN1B
49paraganglioma10.0MEN1, RET
50reticulosarcoma10.0LGALS3, DPP4, CDKN1B

Graphical network of the top 20 diseases related to Follicular Adenoma:



Diseases related to follicular adenoma

Symptoms for Follicular Adenoma

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Drugs & Therapeutics for Follicular Adenoma

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42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

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Genetic Tests for Follicular Adenoma

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Anatomical Context for Follicular Adenoma

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33MalaCards
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MalaCards organs/tissues related to Follicular Adenoma:

33
Thyroid, Bone, Colon, Breast

Animal Models for Follicular Adenoma or affiliated genes

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37MGI
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Publications for Follicular Adenoma

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52PubMed
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Articles related to Follicular Adenoma:

(show top 50)    (show all 101)
idTitleAuthorsYear
1
Unusual association of primary hyperparathyroidism, papillary thyroid carcinoma, and follicular adenoma in a young female. (23776923)
2013
2
Thyroid Follicular Adenoma with Accumulation of Collagen Type IV in a Common Marmoset (Callithrix jacchus). (24060155)
2013
3
Follicular adenoma with extensive extracellular mucin deposition: report on two cases. (23236259)
2012
4
Examination of CD26/DPPIV, p53, and PTEN expression in thyroid follicular adenoma. (22086610)
2012
5
Comparison of proliferating cell nuclear antigen, thyroid transcription factor-1, Ki-67, p63, p53 and high-molecular weight cytokeratin expressions in papillary thyroid carcinoma, follicular carcinoma, and follicular adenoma. (21315633)
2011
6
Thyroid follicular adenoma composed of lipid-rich cells. (21165779)
2011
7
Kikuchi disease and thyroid follicular adenoma. (20859864)
2010
8
Expression of the sonic hedgehog pathway molecules in synchronous follicular adenoma and papillary carcinoma of the thyroid gland in predicting malignancy. (20797751)
2010
9
Clear cell follicular adenoma of the thyroid--a challenge in intra-operative diagnostics. (19235130)
2010
10
Synchronous occurrence of anaplastic, follicular and papillary carcinomas with follicular adenoma in thyroid gland. (20551551)
2010
11
Thyroid follicular adenoma producing parathyroid hormone-related protein with a normal serum calcium level. (19915296)
2009
12
Identification and functional characterization of two novel activating thyrotropin receptor mutants in toxic thyroid follicular adenomas. (19499991)
2009
13
Are there any specific ultrasound findings of nodular hyperplasia ("leave me alone" lesion) to differentiate it from follicular adenoma? (19241229)
2009
14
Correspondence between ultrasonography and histological features in a single thyroid nodule with coexisting follicular adenoma and papillary carcinoma. (18631017)
2008
15
Immunohistochemical analysis of survivin expression in thyroid follicular adenoma and carcinoma. (17122639)
2006
16
111In-Pentetreotide uptake in a follicular adenoma of the thyroid gland: a pitfall for 111In-Pentetreotide scintigraphy. (17173778)
2006
17
Human galectin-3 immunoexpression in thyroid follicular adenomas with cell atypia. (15887854)
2005
18
Diagnostic applicability of dipeptidyl aminopeptidase IV activity in cytological samples for differentiating follicular thyroid carcinoma from follicular adenoma. (14718282)
2004
19
Signet-ring follicular adenoma of the thyroid diagnosed by fine needle aspiration. Report of a case with cytologic description. (14969188)
2004
20
Ectopic thyroid tissue with follicular adenoma mimicking carotid body tumor. (15577811)
2004
21
Is atypical follicular adenoma of the thyroid a preinvasive malignancy? (12874762)
2003
22
Distinctive expression of STAT3 in papillary thyroid carcinomas and a subset of follicular adenomas. (12647789)
2003
23
Usefulness of galectin-3 immunohistochemistry in differential diagnosis between thyroid follicular carcinoma and follicular adenoma. (14575419)
2003
24
Tumor-to-tumor metastases to follicular adenoma of thyroid: case report and review of the literature. (17159402)
2002
25
Large-needle aspiration biopsy for the preoperative selection of follicular adenoma diagnosed by fine-needle aspiration as a microfollicular nodule or suspected cancer. (11943905)
2002
26
Massive bleeding from an ectopic lingual thyroid follicular adenoma during pregnancy. (12019490)
2002
27
Mutation analysis of the Epac--Rap1 signaling pathway in cold thyroid follicular adenomas. (11375794)
2001
28
Follicular adenoma of the thyroid gland with extensive bone metaplasia. (11718227)
2001
29
Follicular adenoma of thyroid associated with mediastinal malignant hemangioendothelioma, masquerading as malignant retrosternal goiter. (11573559)
2001
30
The role of frozen section, gender, age, and tumor size in the differentiation of follicular adenoma from carcinoma: a meta-analysis. (11114645)
2000
31
Development of thyroid follicular adenoma on simvastatin therapy. (10846948)
2000
32
Nuclear area measurements of parathyroid adenoma, parathyroid hyperplasia and thyroid follicular adenoma. A comparison. (9051185)
1997
33
Clear cell follicular adenoma of the thyroid: a case report. (8872434)
1996
34
Follicular adenoma of the thyroid gland in children. (8555125)
1995
35
Differentiation of follicular adenoma and carcinoma of thyroid by immunohistochemical demonstration of ceruloplasmin. (7959983)
1994
36
Carcinomas metastatic to follicular adenomas of the thyroid gland. Report of two cases. (7514864)
1994
37
Translocation t(5;19): a recurrent change in thyroid follicular adenoma. (1377944)
1992
38
Estrogen-receptor protein in thyroid neoplasms. An immunohistochemical analysis of papillary carcinoma, follicular carcinoma, and follicular adenoma. (1768209)
1991
39
Karyometric marker features in fine needle aspirates of follicular adenoma of the thyroid. (2206191)
1990
40
Discrimination between follicular adenoma and follicular carcinoma of the thyroid: preoperative validity of cytometry on aspiration smears. (2640896)
1989
41
CT of follicular adenoma in the thyroid gland. (3628854)
1987
42
Spontaneous thyroid follicular adenoma in a laboratory mouse (Mus musculus). (3803433)
1986
43
Follicular adenoma of the thyroid with intranuclear vacuoles and clear nuclei. A case report. (6592921)
1984
44
Radionuclide demonstration of acute hemorrhage into follicular adenoma of the thyroid. (6299640)
1983
45
Immunoelectron microscopic localization of thyroglobulin in human follicular adenoma. (6367352)
1983
46
A follicular adenoma arising from the thyroid tissue of a benign cystic teratoma during pregnancy--lightmicroscopical, ultrastructural and endocrinological studies. (7240873)
1980
47
Thyroglobulin and other soluble thyroid iodoproteins in papillary carcinoma and follicular adenoma: properties and biosynthesis in vitro. (6778691)
1980
48
Planimetric studies on fine needle aspirates from follicular adenoma and follicular carcinoma of the thyroid. (6989141)
1980
49
Clinical implications of the rare thyroid carcinoma which is indistinguishable from a follicular adenoma. (727220)
1978
50
Differential diagnosis between follicular adenoma and follicular carcinoma of the thyroid by nuclear DNA determination. (269603)
1977

Variations for Follicular Adenoma

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Expression for genes affiliated with Follicular Adenoma

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Follicular Adenoma

Search GEO for disease gene expression data for Follicular Adenoma.

Pathways for genes affiliated with Follicular Adenoma

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50PathCards, 38NCBI BioSystems Database
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Pathways related to Follicular Adenoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5CDKN1B, LGALS3

Compounds for genes affiliated with Follicular Adenoma

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45Novoseek, 61Tocris Bioscience, 24HMDB, 11DrugBank, 51PharmGKB, 29IUPHAR
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Compounds related to Follicular Adenoma according to GeneCards/GeneDecks:

(show all 43)
idCompoundScoreTop Affiliating Genes
1amide459.8DPP4, LGALS3
2eb 108945 6110.7CDKN1B, PTHLH
3hydroxyproline45 24 1111.6DPP4, PTHLH
4ag 1478459.6CDKN1B, PTHLH
5dbc-amp459.5CDKN1B, PTHLH
6sodium dodecylsulfate459.5LGALS3, PTHLH
7lovastatin45 51 61 29 1113.4CDKN1B, PTHLH
8succinate459.4DPP4, RET
9vitamin d459.3PTHLH, MEN1, LGALS3
101,25 dihydroxy vitamin d3459.3PTHLH, CDKN1B
11leptomycin b45 6110.3CDKN1B, LGALS3, PTHLH
12troglitazone45 29 61 1112.3CDKN1B, PTHLH
13matrigel459.3PTHLH, LGALS3, DPP4
14lactate459.3DPP4, LGALS3, PTHLH
15cisplatin45 51 61 1112.2CDKN1B, LGALS3, PTHLH
16thymidine45 2410.2PTHLH, MEN1, CDKN1B
17progesterone45 29 61 24 1113.2PTHLH, LGALS3, CDKN1B
18cycloheximide459.1CDKN1B, DPP4, PTHLH
19wortmannin459.1RET, LGALS3, CDKN1B
20rosiglitazone29 45 51 24 1113.0DPP4, PTHLH
21glutamate458.9CDKN1B, DPP4, LGALS3
22valine458.9DPP4, RET, PTHLH
23oligonucleotide458.9CDKN1B, LGALS3, RET
2412-o-tetradecanoylphorbol 13-acetate458.9CDKN1B, RET, PTHLH
25estrogen458.8CDKN1B, LGALS3, MEN1, PTHLH
26glycogen45 249.8PTHLH, LGALS3, DPP4, CDKN1B
27cyclic amp45 249.8PTHLH, RET, CDKN1B
28heparin45 29 24 1111.8CDKN1B, DPP4, LGALS3, PTHLH
29nitric oxide45 24 1110.8CDKN1B, DPP4, LGALS3, PTHLH
30testosterone45 61 24 1111.7PTHLH, RET, CDKN1B
31butyrate458.6RET, LGALS3, DPP4, CDKN1B
32agar458.5PTHLH, RET, LGALS3, CDKN1B
33paraffin458.5PTHLH, RET, LGALS3, CDKN1B
34arginine458.5PTHLH, RET, LGALS3, CDKN1B
35phosphatidylinositol458.5PTHLH, RET, LGALS3, CDKN1B
36threonine458.5PTHLH, RET, LGALS3, CDKN1B
37vegf458.1PTHLH, RET, MEN1, LGALS3, CDKN1B
38calcium45 51 24 1111.0DPP4, LGALS3, MEN1, RET, PTHLH
39alanine458.0CDKN1B, DPP4, LGALS3, RET, PTHLH
40retinoic acid45 249.0CDKN1B, DPP4, LGALS3, RET, PTHLH
41atp45 299.0PTHLH, RET, LGALS3, DPP4, CDKN1B
42serine457.6CDKN1B, DPP4, LGALS3, MEN1, RET, PTHLH
43tyrosine457.6PTHLH, RET, MEN1, LGALS3, DPP4, CDKN1B

GO Terms for genes affiliated with Follicular Adenoma

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16Gene Ontology
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Biological processes related to Follicular Adenoma according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of cyclin-dependent protein serine/threonine kinase activityGO:0457369.7CDKN1B, MEN1
2osteoblast developmentGO:0020769.6MEN1, PTHLH
3epithelial cell differentiationGO:0308559.5LGALS3, PTHLH
4negative regulation of sequence-specific DNA binding transcription factor activityGO:0434339.5PTHLH, MEN1
5cell cycle arrestGO:0070509.5CDKN1B, MEN1
6MAPK cascadeGO:0001659.2MEN1, RET
7skeletal system developmentGO:0015019.1LGALS3, PTHLH
8negative regulation of cell proliferationGO:0082859.1PTHLH, MEN1, CDKN1B
9activation of cysteine-type endopeptidase activity involved in apoptotic processGO:0069199.0RET, CDKN1B
10positive regulation of cell proliferationGO:0082849.0CDKN1B, DPP4, PTHLH

Products for genes affiliated with Follicular Adenoma

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Sources for Follicular Adenoma

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
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