MCID: FLL031
MIFTS: 41

Follicular Adenoma

Categories: Endocrine diseases, Cancer diseases

Aliases & Classifications for Follicular Adenoma

MalaCards integrated aliases for Follicular Adenoma:

Name: Follicular Adenoma 12 14 69
Follicular Adenoma of the Thyroid Gland 12
Thyroid Gland Follicular Adenoma 69
Thyroid Follicular Adenoma 12
Adenoma Follicular 51

Classifications:



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Disease Ontology 12 DOID:6204
MeSH 41 D000236
SNOMED-CT 64 55021007

Summaries for Follicular Adenoma

MalaCards based summary : Follicular Adenoma, also known as follicular adenoma of the thyroid gland, is related to atypical follicular adenoma and thyroiditis. An important gene associated with Follicular Adenoma is MINPP1 (Multiple Inositol-Polyphosphate Phosphatase 1), and among its related pathways/superpathways are Human Thyroid Stimulating Hormone (TSH) signaling pathway and Thyroxine (Thyroid Hormone) Production. The drugs Iodine and Formaldehyde have been mentioned in the context of this disorder. Affiliated tissues include thyroid, bone and colon, and related phenotypes are Increased shRNA abundance and endocrine/exocrine gland

Related Diseases for Follicular Adenoma

Diseases related to Follicular Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 91)
# Related Disease Score Top Affiliating Genes
1 atypical follicular adenoma 33.9 CALCA TG
2 thyroiditis 30.6 CALCA RET TG TPO TSHR
3 primary hyperparathyroidism 29.8 CALCA CDKN1B RET
4 hyperparathyroidism 29.8 CALCA CDKN1B RET
5 small cell carcinoma 29.8 CALCA NKX2-1 PTEN
6 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 29.7 TG TPO TSHR
7 cowden disease 29.5 CALCA PTEN RET TG
8 goiter 28.4 CALCA NKX2-1 PAX8 TG TPO TSHR
9 hypothyroidism 28.4 NKX2-1 PAX8 TG TPO TSHR
10 papillary carcinoma 28.1 CALCA KRT19 LGALS3 NKX2-1 PAX8 RET
11 multinodular goiter 28.1 CALCA NKX2-1 PAX8 TG TPO TSHR
12 thyroid cancer, nonmedullary, 1 27.6 CALCA KRT19 LGALS3 NKX2-1 PAX8 PTEN
13 thyroid cancer 26.4 CALCA CDKN1B KRT19 LGALS3 NKX2-1 PAX8
14 thyroid cancer, nonmedullary, 2 26.1 CALCA DPP4 KRT19 LGALS3 MINPP1 NKX2-1
15 oncocytoma 11.0
16 adenoma 10.7
17 familial thyroid dyshormonogenesis 10.5 TG TPO
18 subacute lymphocytic thyroiditis 10.5 TG TPO
19 goiter, multinodular 1, with or without sertoli-leydig cell tumors 10.5 TG TPO
20 mucoepidermoid thyroid carcinoma 10.5 CALCA TG
21 mucinous bronchioloalveolar adenocarcinoma 10.4 LGALS3 NKX2-1
22 suppurative thyroiditis 10.4 CALCA TG
23 thyroid sarcoma 10.4 CALCA TG
24 malignant teratoma 10.4 NKX2-1 TG
25 plummer's disease 10.4 TG TPO
26 acute thyroiditis 10.4 CALCA TG
27 corneal abscess 10.4 KRT19 PTEN
28 premature menopause 10.4 TG TPO
29 hypothyroidism, congenital, nongoitrous, 4 10.3 TG TPO
30 hypoadrenalism 10.3 CALCA TG
31 ovarian germ cell teratoma 10.3 NKX2-1 RET TG
32 ovarian germ cell cancer 10.3 NKX2-1 RET TG
33 polyposis, skin pigmentation, alopecia, and fingernail changes 10.3 KRT19 PTEN
34 pernicious anemia 10.3 TG TPO
35 hypothyroidism, thyroidal or athyroidal, with spiky hair and cleft palate 10.2 TG TPO
36 ovarian cystic teratoma 10.2 CALCA NKX2-1 TG
37 cell type cancer 10.2 KRT19 NKX2-1 PTEN
38 small cell cancer of the lung 10.2 CALCA KRT19 NKX2-1
39 benign struma ovarii 10.2 RET TG TSHR
40 graves disease 1 10.1 TG TPO TSHR
41 myxedema 10.1 TG TPO TSHR
42 subacute thyroiditis 10.1 TG TPO TSHR
43 celiac disease 1 10.1 DPP4 TG TPO
44 autoimmune disease of endocrine system 10.1 TG TPO TSHR
45 hypersensitivity reaction disease 10.1 TG TPO TSHR
46 multiple endocrine neoplasia 10.1 CALCA CDKN1B RET
47 hyperthyroxinemia 10.1 TPO TSHR
48 hyperthyroidism 10.1 TG TPO TSHR
49 amyloid tumor 10.1 CALCA TG
50 water-clear cell adenoma 10.1 PAX8 TG

Graphical network of the top 20 diseases related to Follicular Adenoma:



Diseases related to Follicular Adenoma

Symptoms & Phenotypes for Follicular Adenoma

GenomeRNAi Phenotypes related to Follicular Adenoma according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance GR00327-A 8.92 CALCA CDKN1B LGALS3 MCM2

MGI Mouse Phenotypes related to Follicular Adenoma:

43 (show all 13)
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 10.27 KRT19 NKX2-1 CDKN1B MCM2 DPP4 TPO
2 growth/size/body region MP:0005378 10.26 TSHR KRT19 NKX2-1 CDKN1B MCM2 DPP4
3 cellular MP:0005384 10.22 TSHR KRT19 NKX2-1 LGALS3 CDKN1B MCM2
4 homeostasis/metabolism MP:0005376 10.17 TSHR DPP4 NKX2-1 LGALS3 CDKN1B PTEN
5 mortality/aging MP:0010768 10.14 TSHR KRT19 NKX2-1 LGALS3 CDKN1B MCM2
6 hematopoietic system MP:0005397 10.11 TSHR MCM2 LGALS3 CDKN1B TP53BP1 PTEN
7 digestive/alimentary MP:0005381 10.05 KRT19 NKX2-1 LGALS3 CDKN1B MCM2 PTEN
8 neoplasm MP:0002006 10.02 TSHR KRT19 NKX2-1 LGALS3 CDKN1B MCM2
9 nervous system MP:0003631 10.02 TSHR KRT19 NKX2-1 LGALS3 CDKN1B MCM2
10 reproductive system MP:0005389 9.81 TSHR KRT19 NKX2-1 LGALS3 CDKN1B PTEN
11 normal MP:0002873 9.8 MCM2 MINPP1 KRT19 PTEN NKX2-1 RET
12 respiratory system MP:0005388 9.43 MCM2 LGALS3 CDKN1B PTEN NKX2-1 RET
13 skeleton MP:0005390 9.23 TSHR KRT19 NKX2-1 LGALS3 CDKN1B PTEN

Drugs & Therapeutics for Follicular Adenoma

Drugs for Follicular Adenoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Iodine Approved, Investigational 7553-56-2 807
2
Formaldehyde Approved, Vet_approved 50-00-0 712
3 cadexomer iodine

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Evaluation of a New CZT System Unknown status NCT01084356
2 Biomarkers to Distinguish Benign From Malignant Thyroid Neoplasm Completed NCT01433809
3 Molecular Markers in Thyroid Cancer Completed NCT00598364
4 Expression of NIS Protein and mRNA in Thyroid Tumors Completed NCT00459498
5 Alterations in Muscle's Functional Characteristics After Parathyroid Surgery for Primary Hyperparathyroidism. Recruiting NCT03091140
6 Expression of Protein Convertases in Thyroid Nodules Enrolling by invitation NCT03160482
7 ctDNA in Patients With Thyroid Nodules Terminated NCT02778412

Search NIH Clinical Center for Follicular Adenoma

Genetic Tests for Follicular Adenoma

Anatomical Context for Follicular Adenoma

MalaCards organs/tissues related to Follicular Adenoma:

38
Thyroid, Bone, Colon, Lung

Publications for Follicular Adenoma

Articles related to Follicular Adenoma:

(show top 50) (show all 124)
# Title Authors Year
1
A six-gene panel to label follicular adenoma, low- and high-risk follicular thyroid carcinoma. ( 29298844 )
2018
2
Artificial neural network model to distinguish follicular adenoma from follicular carcinoma on fine needle aspiration of thyroid. ( 29266871 )
2018
3
Follicular adenoma in ectopic thyroid. A case-report. ( 28946030 )
2017
4
Tumor-to-tumor metastasis: Small cell carcinoma lung metastasising into a follicular adenoma of the thyroid. ( 28195115 )
2017
5
A rare presentation: A case report of osseous metaplasia and mature bone formation in a follicular adenoma of the thyroid. ( 28648877 )
2017
6
Can Nodular Hyperplasia of the Thyroid Gland be Differentiated From Follicular Adenoma and Follicular Carcinoma by Ultrasonography? ( 27870787 )
2016
7
Mutational burdens and evolutionary ages of thyroid follicular adenoma are comparable to those of follicular carcinoma. ( 27626165 )
2016
8
Incidental ectopic thyroid follicular adenoma on myocardial perfusion imaging. ( 26122882 )
2016
9
Expression of ARE-binding proteins AUF1 and HuR in follicular adenoma and carcinoma of thyroid gland. ( 26925783 )
2016
10
Thyroid follicular adenoma with numerous intracytoplasmic lumina mimicking yellow bodies: a case report. ( 27146719 )
2016
11
Papillary Thyroid Carcinoma Arising Within a Follicular Adenoma: A Case Report, Ultrasound Features, and Considerations. ( 27110655 )
2016
12
Association between p53-binding protein 1 expression and genomic instability in oncocytic follicular adenoma of the thyroid. ( 26935218 )
2016
13
Appearance of HA1rthle cell carcinoma soon after surgical extirpation of HA1rthle cell adenoma and follicular adenoma of the thyroid gland. ( 25810698 )
2015
14
Not All Post-FNA Spindle Cell Proliferations in the Thyroid Are of Myofibroblastic Origin: Follicular Adenoma with Spindle Cell Metaplasia. ( 26490689 )
2015
15
Identification of Novel Biomarker and Therapeutic Target Candidates for Diagnosis and Treatment of Follicular Adenoma. ( 26543076 )
2015
16
Comparison of microarray expression profiles between follicular variant of papillary thyroid carcinomas and follicular adenomas of the thyroid. ( 25923053 )
2015
17
Risk of thyroid follicular adenoma among children and adolescents in Belarus exposed to iodine-131 after the Chornobyl accident. ( 26443421 )
2015
18
Determination-of apoptosis and cell cycle modulators (p16, p21, p27, p53, BCL-2, Bax, BCL-xL, and cyclin D1) in thyroid follicular carcinoma, follicular adenoma, and adenomatous nodules via a tissue microarray method. ( 26422859 )
2015
19
Better understanding in the differentiation of thyroid follicular adenoma, follicular carcinoma, and follicular variant of papillary carcinoma: a retrospective study. ( 25309594 )
2014
20
Meningioma like tumour of thyroid: a rare variant of follicular adenoma. ( 24640816 )
2014
21
Sonographic features of thyroid follicular carcinoma in comparison with thyroid follicular adenoma. ( 24449724 )
2014
22
How should a follicular adenoma with papillary architecture be classified on thyroid FNA? Case report with histological correlation. ( 25073478 )
2014
23
The unique liquid-based cytologic findings of thyroid signet-ring follicular adenoma: a report of two cases with fine needle aspiration cytology. ( 23220878 )
2013
24
Molecular differences between human thyroid follicular adenoma and carcinoma revealed by analysis of a murine model of thyroid cancer. ( 23751876 )
2013
25
Unusual association of primary hyperparathyroidism, papillary thyroid carcinoma, and follicular adenoma in a young female. ( 23776923 )
2013
26
Thyroid Follicular Adenoma with Accumulation of Collagen Type IV in a Common Marmoset (Callithrix jacchus). ( 24060155 )
2013
27
Examination of CD26/DPPIV, p53, and PTEN expression in thyroid follicular adenoma. ( 22086610 )
2012
28
Genetic studies in a coexistence of acromegaly, pheochromocytoma, gastrointestinal stromal tumor (GIST) and thyroid follicular adenoma. ( 23295290 )
2012
29
Follicular adenoma with extensive extracellular mucin deposition: report on two cases. ( 23236259 )
2012
30
Follicular adenoma presenting as lateral aberrant thyroid. ( 21854673 )
2012
31
Value of immunohistochemical expression of p27 and galectin-3 in differentiation between follicular adenoma and follicular carcinoma. ( 22553813 )
2012
32
Fine needle aspiration biopsy of an unusual follicular adenoma with sebaceous-like features. ( 22527948 )
2012
33
A case of asymptomatic riedel thyroiditis with follicular adenoma in a patient with a multinodular goiter: an unusual association. ( 24783021 )
2012
34
Squamous cell components in a thyroid follicular adenoma: significant evidence of follicular cell origin by histomorphological, immunohistochemical and molecular analyses. ( 21951666 )
2011
35
Comparison of proliferating cell nuclear antigen, thyroid transcription factor-1, Ki-67, p63, p53 and high-molecular weight cytokeratin expressions in papillary thyroid carcinoma, follicular carcinoma, and follicular adenoma. ( 21315633 )
2011
36
Follicular adenoma and carcinoma of the thyroid gland. ( 21482585 )
2011
37
Cytologic features of focal papillary thyroid carcinoma arising within follicular adenoma: a masked cytomorphologic analysis of 17 cases. ( 22156462 )
2011
38
Comment on: synchronous occurrence of anaplastic, follicular, and papillary carcinoma with follicular adenoma in thyroid gland. ( 21623130 )
2011
39
Differential diagnosis of follicular cancer and follicular adenoma using an expert system based on a set of qualitative signs of cell atypia. ( 22611752 )
2011
40
Synchronous occurrence of anaplastic, follicular and papillary carcinomas with follicular adenoma in thyroid gland. ( 21623114 )
2011
41
Thyroid follicular adenoma composed of lipid-rich cells. ( 21165779 )
2011
42
Clear cell follicular adenoma of the thyroid--a challenge in intra-operative diagnostics. ( 19235130 )
2010
43
Synchronous occurrence of anaplastic, follicular and papillary carcinomas with follicular adenoma in thyroid gland. ( 20551551 )
2010
44
Expression of the sonic hedgehog pathway molecules in synchronous follicular adenoma and papillary carcinoma of the thyroid gland in predicting malignancy. ( 20797751 )
2010
45
Signet-ring cell follicular adenoma of the thyroid. ( 20132181 )
2010
46
Kikuchi disease and thyroid follicular adenoma. ( 20859864 )
2010
47
Thyroid follicular adenoma producing parathyroid hormone-related protein with a normal serum calcium level. ( 19915296 )
2009
48
Differential expression of CK 19 in follicular adenoma, well-differentiated tumour of uncertain malignant potential (WDT-UMP) and follicular variant of papillary carcinoma. ( 19213370 )
2009
49
Osseous metaplasia and mature bone formation with extramedullary hematopoiesis in follicular adenoma of thyroid gland. ( 19679966 )
2009
50
Are there any specific ultrasound findings of nodular hyperplasia ("leave me alone" lesion) to differentiate it from follicular adenoma? ( 19241229 )
2009

Variations for Follicular Adenoma

ClinVar genetic disease variations for Follicular Adenoma:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 MINPP1 MINPP1, IVS3, T-A, +34 single nucleotide variant Pathogenic

Expression for Follicular Adenoma

Search GEO for disease gene expression data for Follicular Adenoma.

Pathways for Follicular Adenoma

Pathways related to Follicular Adenoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.96 CDKN1B PAX8 TSHR
2 9.58 TG TPO TSHR

GO Terms for Follicular Adenoma

Biological processes related to Follicular Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of epithelial to mesenchymal transition GO:0010719 9.4 NKX2-1 PTEN
2 response to pain GO:0048265 9.37 CALCA RET
3 endothelial cell migration GO:0043542 9.33 CALCA DPP4 PTEN
4 hormone biosynthetic process GO:0042446 9.32 TG TPO
5 positive regulation of adenylate cyclase activity GO:0045762 9.26 CALCA TSHR
6 thyroid-stimulating hormone signaling pathway GO:0038194 8.96 PAX8 TSHR
7 thyroid gland development GO:0030878 8.8 NKX2-1 PAX8 TG

Molecular functions related to Follicular Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein complex binding GO:0032403 9.46 CALCA CDKN1B KRT19 TSHR
2 inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity GO:0051717 8.96 MINPP1 PTEN
3 thyroid-stimulating hormone receptor activity GO:0004996 8.62 PAX8 TSHR

Sources for Follicular Adenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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