MCID: FLL031
MIFTS: 43

Follicular Adenoma malady

Summaries for Follicular Adenoma

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64Wikipedia, 33MalaCards
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Wikipedia:64 A thyroid adenoma is a benign tumor of the thyroid gland. more...

MalaCards: Follicular Adenoma, also known as follicular adenoma of the thyroid gland, is related to adenoma and papillary carcinoma. An important gene associated with Follicular Adenoma is LGALS3 (lectin, galactoside-binding, soluble, 3), and among its related pathways are Bisphosphonate Pathway, Pharmacodynamics and GRB2:SOS provides linkage to MAPK signaling for Intergrins . The compounds cycloheximide and estrogen have been mentioned in the context of this disorder. Related mouse phenotypes are homeostasis/metabolism and endocrine/exocrine gland.

Aliases & Classifications for Follicular Adenoma

Sources:
8Disease Ontology, 10DISEASES, 61UMLS, 45Novoseek, 35MeSH, 57SNOMED-CT
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Aliases & Descriptions:

follicular adenoma 8 10 61
follicular adenoma of the thyroid gland 8
thyroid follicular adenoma 8
adenoma follicular 45


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Disease Ontology8 DOID:6204
SNOMED-CT57 55021007
MeSH35 D000236

Related Diseases for Follicular Adenoma

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Follicular Adenoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 97)
idRelated DiseaseScoreTop Affiliating Genes
1adenoma31.5CP, S100A4, LGALS3, ACPP, KRT19, HMGCR
2papillary carcinoma30.9S100A4, DPP4, CDKN1B, RET, KRT19, LGALS3
3primary hyperparathyroidism30.2MEN1, RET, PTHLH
4acromegaly30.0MEN1
5parathyroid carcinoma30.0RET, MEN1
6pheochromocytoma30.0IL6R, RET, MEN1
7astrocytoma30.0CDKN1B, RAP1A, LGALS3
8thyroid cancer30.0CDKN1B, RET, KRT19, LGALS3
9adenocarcinoma30.0S100A4, MEN1, DPP4, CDKN1B, MCM2, MCM7
10thyroid adenoma11.0
11papillary adenoma10.7
12clear cell adenoma10.4
13atypical follicular adenoma10.3
14pregnancy adenoma10.2
15oxyphilic adenoma10.0
16sebaceous adenoma10.0
17gastrointestinal stromal tumor10.0
18spindle cell carcinoma10.0
19cowden disease10.0
20gastrointestinal adenoma10.0
21breast adenoma10.0
22carotid body tumor10.0
23ectopic pregnancy10.0
24hemangioendothelioma10.0
25kikuchi disease10.0
26teratoma10.0
27meningioma10.0MEN1
28prostatitis10.0ACPP
29nasopharyngitis10.0DPP4
30laryngeal squamous cell carcinoma10.0KRT19, MCM2
31oligodendroglioma10.0LGALS3, MCM7
32paraganglioma10.0MEN1, RET
33cervical adenocarcinoma10.0CDKN1B
34graves' disease10.0LGALS3, IL6R
35myeloid leukemia10.0RAP1A
36hyperparathyroidism-jaw tumor syndrome10.0MEN1, RET
37hepatitis10.0CP, DPP4
38ovarian cancer10.0IL6R, CDKN1B
39von hippel-lindau disease10.0RET, MEN1
40goiter10.0S100A4, RET, LGALS3
41chordoma10.0LGALS3, KRT19
42cholangiocarcinoma10.0CDKN1B, KRT19, LGALS3
43pituitary tumors10.0LGALS3, CDKN1B, MEN1
44bladder carcinoma10.0CDKN1B, MCM2, KRT19
45cervical squamous cell carcinoma10.0CDKN1B
46hyperglycemia10.0HMGCR, DPP4
47autoimmune thyroiditis10.0RET, KRT19, LGALS3
48hypothyroidism10.0LGALS3, RET, DPP4
49thyroid medullary carcinoma10.0MEN1, RET, LGALS3
50squamous cell carcinoma10.0LGALS3, PTHLH, KRT19

Graphical network of the top 20 diseases related to Follicular Adenoma:



Diseases related to follicular adenoma

Clinical Features for Follicular Adenoma

Drugs & Therapeutics for Follicular Adenoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Follicular Adenoma

Drug clinical trials:

Search ClinicalTrials for Follicular Adenoma

Search NIH Clinical Center for Follicular Adenoma

Search CenterWatch for Follicular Adenoma

Genetic Tests for Follicular Adenoma

Anatomical Context for Follicular Adenoma

Animal Models for Follicular Adenoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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Publications for Follicular Adenoma

Sources:
51PubMed
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Articles related to Follicular Adenoma:

(show top 50)    (show all 137)
idTitleAuthorsYear
1
"Glomeruloid" follicular thyroid adenoma. (23637255)
2013
2
Molecular differences between human thyroid follicular adenoma and carcinoma revealed by analysis of a murine model of thyroid cancer. (23751876)
2013
3
Follicular adenoma with extensive extracellular mucin deposition: report on two cases. (23236259)
2012
4
Case of tubular apocrine adenoma with follicular differentiation located on the trunk. (21906134)
2012
5
Value of immunohistochemical expression of p27 and galectin-3 in differentiation between follicular adenoma and follicular carcinoma. (22553813)
2012
6
Follicular thyroid adenoma dominated by spindle cells: report of two unusual cases and literature review. (22400075)
2012
7
Thyroid follicular adenoma composed of lipid-rich cells. (21165779)
2011
8
Differential diagnosis of follicular cancer and follicular adenoma using an expert system based on a set of qualitative signs of cell atypia. (22611752)
2011
9
Follicular adenoma and carcinoma of the thyroid gland. (21482585)
2011
10
Squamous cell components in a thyroid follicular adenoma: significant evidence of follicular cell origin by histomorphological, immunohistochemical and molecular analyses. (21951666)
2011
11
Follicular thyroid adenoma with eggshell calcification presenting as an intensely hypermetabolic lesion on 18F-FDG PET/CT. (19655340)
2010
12
Clear cell follicular adenoma of the thyroid--a challenge in intra-operative diagnostics. (19235130)
2010
13
Thyroid follicular adenoma producing parathyroid hormone-related protein with a normal serum calcium level. (19915296)
2009
14
F-18 FDG-avid intrathyroidal parathyroid adenoma mimicking follicular neoplasm. (19352286)
2009
15
Are there any specific ultrasound findings of nodular hyperplasia ("leave me alone" lesion) to differentiate it from follicular adenoma? (19241229)
2009
16
Mucoepidermoid (adenosquamous) carcinoma, trichoblastoma, trichilemmoma, sebaceous adenoma, tumor of follicular infundibulum and syringocystadenoma papilliferum arising within 2 persistent lesions of nevus sebaceous: report of a case. (19652586)
2009
17
Osseous metaplasia and mature bone formation with extramedullary hematopoiesis in follicular adenoma of thyroid gland. (19679966)
2009
18
Fine-needle aspiration of follicular adenoma versus parathyroid adenoma: the utility of multispectral imaging in differentiating lesions with subtle cytomorphologic differences. (18085636)
2008
19
Pten loss in the mouse thyroid causes goiter and follicular adenomas: insights into thyroid function and Cowden disease pathogenesis. (17283127)
2007
20
Follicular adenoma in a thyroglossal duct. (17684668)
2007
21
Immunohistochemical separation of follicular variant of papillary thyroid carcinoma from follicular adenoma. (17308358)
2006
22
Tumor-to-tumor metastasis to a thyroid follicular adenoma as the initial presentation of a colonic adenocarcinoma. (16143033)
2005
23
Follicular adenoma in a juxtathyroidal thyroglossal duct cyst with papillary carcinoma in the adjacent thyroid gland. (16137536)
2005
24
Immunostaining of galectin-3 and CD44v6 using fine-needle aspiration for distinguishing follicular carcinoma from adenoma. (15540177)
2004
25
Signet-ring follicular adenoma of the thyroid diagnosed by fine needle aspiration. Report of a case with cytologic description. (14969188)
2004
26
Ectopic thyroid tissue with follicular adenoma mimicking carotid body tumor. (15577811)
2004
27
Carcinoembryonic antigen mRNA in blood: distinguishing follicular thyroid carcinoma from adenoma. (14588107)
2003
28
Distinctive expression of STAT3 in papillary thyroid carcinomas and a subset of follicular adenomas. (12647789)
2003
29
Usefulness of galectin-3 immunohistochemistry in differential diagnosis between thyroid follicular carcinoma and follicular adenoma. (14575419)
2003
30
Large-needle aspiration biopsy for the preoperative selection of follicular adenoma diagnosed by fine-needle aspiration as a microfollicular nodule or suspected cancer. (11943905)
2002
31
Mutation analysis of the Epac--Rap1 signaling pathway in cold thyroid follicular adenomas. (11375794)
2001
32
Follicular adenoma of the thyroid gland with extensive bone metaplasia. (11718227)
2001
33
Long-term follow-up of contralateral lobe in patients hemithyroidectomized for solitary follicular adenoma. (11678834)
2001
34
Development of thyroid follicular adenoma on simvastatin therapy. (10846948)
2000
35
Solitary follicular thyroid carcinoma of the skull base and its differentiation from ectopic adenoma--review, use of galectin-3 and report of a new case. (10996713)
2000
36
Undefined complications of parathyroid adenoma, parathyroid hyperplasia (primary hyperparathyroidism), thyroid follicular adenoma, thyroid papillary carcinoma, temporal astrocytoma, cerebellar meningioma, and hemangioma of external auditory meatus and oral papilloma. (11030206)
2000
37
Translocations (X;10)(p22;q24) and (1;10)(q21;q11) in a follicular adenoma of the thyroid without apparent involvement of the RET protooncogene. (10686949)
1999
38
Clear cell follicular adenoma of the thyroid: a case report. (8872434)
1996
39
Differentiation of follicular adenoma and carcinoma of thyroid by immunohistochemical demonstration of ceruloplasmin. (7959983)
1994
40
Transforming growth factor-beta 1 is more expressed in thyroid follicular adenoma than in normal tissue. (8077617)
1994
41
Involvement of 19q13 in follicular thyroid adenoma. (1591716)
1992
42
Clear-cell change in follicular adenoma mimicking HA1rthle-cell tumor on thyroid aspiration biopsy cytology. (1879263)
1991
43
Studies on the mechanism of simvastatin-induced thyroid hypertrophy and follicular cell adenoma in the rat. (1780636)
1991
44
Intraluminal crystalloids in follicular adenoma of the thyroid. (1898242)
1991
45
Differential diagnosis between thyroid follicular adenoma and carcinoma. Analytic morphometric approach. (2626383)
1989
46
Clear cell follicular adenoma of the thyroid. (3821125)
1987
47
Follicular adenoma of the thyroid with intranuclear vacuoles and clear nuclei. A case report. (6592921)
1984
48
Radionuclide demonstration of acute hemorrhage into follicular adenoma of the thyroid. (6299640)
1983
49
Thyroglobulin and other soluble thyroid iodoproteins in papillary carcinoma and follicular adenoma: properties and biosynthesis in vitro. (6778691)
1980
50
Planimetric studies on fine needle aspirates from follicular adenoma and follicular carcinoma of the thyroid. (6989141)
1980

Genetic Variations for Follicular Adenoma

Expression for genes affiliated with Follicular Adenoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Follicular Adenoma

Search GEO for disease gene expression data for Follicular Adenoma.

Pathways for genes affiliated with Follicular Adenoma

Sources:
50PharmGKB, 54Reactome, 38NCBI BioSystems Database, 30KEGG, 4Cell Signaling Technology
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Compounds for genes affiliated with Follicular Adenoma

Sources:
45Novoseek, 24HMDB, 11DrugBank, 60Tocris Bioscience, 50PharmGKB, 29IUPHAR
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Compounds related to Follicular Adenoma according to GeneCards/GeneDecks:

(show top 50)    (show all 51)
idCompoundScoreTop Affiliating Genes
1cycloheximide4510.7DPP4
2estrogen4510.6ACPP
3glycogen45 2411.4PTHLH, IL6R, CDKN1B
4estradiol45 11 2412.4ACPP, PTHLH
5carbohydrates4510.3DPP4, KRT19, CP
6leptomycin b45 6011.3CDKN1B, PTHLH, LGALS3
7paclitaxel45 50 1112.3KRT19, CDKN1B
8heparin45 29 11 2413.2DPP4, CDKN1B, HMGCR, CP
9Alpha-D-Mannose1110.2ACPP, IL6R, DPP4
10sodium dodecylsulfate4510.2CP
11hematoxylin4510.1LGALS3, ACPP, KRT19
12methotrexate45 50 1112.1HMGCR, IL6R, CDKN1B, DPP4
13perillyl alcohol45 2411.0HMGCR, RAP1A
14matrigel4510.0S100A4, DPP4, KRT19, PTHLH, LGALS3
15lovastatin45 50 60 29 1114.0PTHLH, HMGCR, CDKN1B
16vitamin d459.9MEN1, ACPP, PTHLH, LGALS3, CP
17fibrinogen459.9IL6R, KRT19, LGALS3, CP
18epinephrine45 11 2411.9CP, HMGCR, RAP1B, RAPGEF3
19ribonucleic acid459.9RET, IL6R, KRT19, PTHLH
20glutamine459.9CDKN1B, IL6R, RAP1A, LGALS3, CP
21wortmannin459.9CDKN1B, RET, IL6R, RAP1B, LGALS3
22cisplatin45 50 60 1112.8CDKN1B, KRT19, ACPP, PTHLH, LGALS3
23thymidine45 2410.8MEN1, CDKN1B, IL6R, KRT19, ACPP, PTHLH
2412-o-tetradecanoylphorbol 13-acetate459.8CDKN1B, RET, IL6R, RAP1A, PTHLH
25cholesterol45 29 11 2412.7DPP4, CDKN1B, IL6R, HMGCR, ACPP, CP
26glucose459.7CDKN1B, IL6R, RAPGEF3, KRT19, PTHLH
27tartrate459.7PTHLH, ACPP
28aspartate459.7DPP4, RET, KRT19, ACPP, CP
29adenylate459.7DPP4, RAP1A, RAPGEF3, PTHLH, CP
30lactate459.6DPP4, HMGCR, KRT19, ACPP, PTHLH, LGALS3
31creatinine459.6DPP4, IL6R, HMGCR, KRT19, ACPP, PTHLH
32progesterone45 60 29 11 2413.6S100A4, CDKN1B, IL6R, KRT19, ACPP, PTHLH
33oligonucleotide459.5LGALS3, ACPP, IL6R, RET, CDKN1B, S100A4
34oxygen45 2410.5CDKN1B, RAP1A, KRT19, PTHLH, LGALS3, CP
35threonine459.5LGALS3, PTHLH, RAP1A, RET, MCM2, CDKN1B
36ly294002459.5RAP1B, RAP1A, RET, CDKN1B
37testosterone45 60 11 2412.5CDKN1B, RET, IL6R, KRT19, ACPP, PTHLH
38atp45 2910.5DPP4, CDKN1B, RET, KRT19, ACPP, PTHLH
39paraffin459.5CDKN1B, MCM2, RET, KRT19, ACPP, PTHLH
40cyclic amp45 2410.4CDKN1B, RET, RAP1A, RAPGEF3, RAP1B, PTHLH
41agar459.4CDKN1B, RET, RAP1A, ACPP, PTHLH, LGALS3
42alanine459.3DPP4, CDKN1B, MCM2, RET, ACPP, PTHLH
43retinoic acid45 2410.2S100A4, DPP4, CDKN1B, RET, IL6R, KRT19
44serine459.2CSNK1G2, MEN1, CDKN1B, MCM2, RET, HMGCR
45phosphatidylinositol459.2CDKN1B, RET, IL6R, RAP1A, RAPGEF3, RAP1B
46lipid459.1RET, IL6R, RAP1A, HMGCR, ACPP, PTHLH
47arginine459.0CDKN1B, RET, IL6R, RAP1A, HMGCR, ACPP
48vegf458.7CP, MEN1, CDKN1B, RET, IL6R, RAP1A
49calcium45 50 11 2411.5S100A4, MEN1, DPP4, RET, IL6R, RAP1A
50tyrosine458.2MCM7, CDKN1B, DPP4, MEN1, S100A4, RET

GO Terms for genes affiliated with Follicular Adenoma

Sources:
16Gene Ontology
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Cellular components related to Follicular Adenoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MCM complexGO:04255510.0MCM7, MCM2
2chromatinGO:0007859.6MCM7, MCM2, MEN1

Biological processes related to Follicular Adenoma according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1DNA unwinding involved in DNA replicationGO:00626810.0MCM2, MCM7
2regulation of cell junction assemblyGO:190188810.0RAP1B, RAP1A
3positive regulation of Rap GTPase activityGO:03285410.0RAPGEF3, RAP1A
4establishment of endothelial barrierGO:0610289.9RAP1B, RAPGEF3, RAP1A
5Rap protein signal transductionGO:0324869.8RAP1B, RAPGEF3, RAP1A
6cellular response to cAMPGO:0713209.8RAP1A, RAPGEF3, RAP1B
7energy reserve metabolic processGO:0061129.7RAP1B, RAPGEF3, RAP1A
8regulation of insulin secretionGO:0507969.4RAP1A, RAPGEF3, RAP1B
9small molecule metabolic processGO:0442818.7CSNK1G2, RAP1A, RAPGEF3, RAP1B, HMGCR, SLC25A32

Molecular functions related to Follicular Adenoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Rap guanyl-nucleotide exchange factor activityGO:0170349.9RAPGEF3, RAP1A
2protein bindingGO:0055157.3LGALS3, S100A4, MEN1, DPP4, CDKN1B, MCM2

Products for genes affiliated with Follicular Adenoma

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Sources for Follicular Adenoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet