MCID: FLL031
MIFTS: 49

Follicular Adenoma malady

Endocrine diseases category

Summaries for Follicular Adenoma

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63Wikipedia, 32MalaCards
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Wikipedia:63 A thyroid adenoma is a benign tumor of the thyroid gland. more...

MalaCards: Follicular Adenoma, also known as follicular adenoma of the thyroid gland, is related to adenoma and follicular thyroid carcinoma. An important gene associated with Follicular Adenoma is LGALS3 (lectin, galactoside-binding, soluble, 3), and among its related pathways are Bisphosphonate Pathway, Pharmacodynamics and GRB2:SOS provides linkage to MAPK signaling for Intergrins . The compounds cycloheximide and estrogen have been mentioned in the context of this disorder. Affiliated tissues include thyroid, bone and colon, and related mouse phenotypes are homeostasis/metabolism and endocrine/exocrine gland.

Aliases & Classifications for Follicular Adenoma

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 34MeSH, 56SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Endocrine diseases


Aliases & Descriptions:

follicular adenoma 8 10 60
follicular adenoma of the thyroid gland 8
thyroid follicular adenoma 8
adenoma follicular 44


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Disease Ontology8 DOID:6204
SNOMED-CT56 55021007
MeSH34 D000236

Related Diseases for Follicular Adenoma

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17GeneCards, 18GeneDecks
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Diseases related to Follicular Adenoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 101)
idRelated DiseaseScoreTop Affiliating Genes
1adenoma31.4CP, S100A4, LGALS3, ACPP, KRT19, HMGCR
2follicular thyroid carcinoma31.1DPP4, RET, KRT19, LGALS3
3papillary carcinoma30.9S100A4, DPP4, CDKN1B, RET, KRT19, LGALS3
4papillary thyroid carcinoma30.9S100A4, MEN1, RET, RAP1A, KRT19, LGALS3
5parathyroid adenoma30.4MEN1, CDKN1B, RET, PTHLH, LGALS3
6meningioma30.2MEN1
7goiter30.2S100A4, RET, LGALS3
8primary hyperparathyroidism30.2MEN1, RET, PTHLH
9hyperparathyroidism30.2PTHLH, RET, CDKN1B, MEN1
10acromegaly30.0MEN1
11parathyroid carcinoma30.0RET, MEN1
12autoimmune thyroiditis30.0RET, KRT19, LGALS3
13pheochromocytoma30.0IL6R, RET, MEN1
14astrocytoma30.0CDKN1B, RAP1A, LGALS3
15colon adenocarcinoma30.0LGALS3, CDKN1B, DPP4, S100A4
16thyroid cancer30.0CDKN1B, RET, KRT19, LGALS3
17adenocarcinoma29.9S100A4, MEN1, DPP4, CDKN1B, MCM2, MCM7
18thyroiditis11.0
19papillary adenoma10.6
20clear cell adenoma10.3
21atypical follicular adenoma10.3
22pregnancy adenoma10.1
23acute thyroiditis10.0
24oxyphilic adenoma10.0
25sebaceous adenoma10.0
26gastrointestinal stromal tumor10.0
27spindle cell carcinoma10.0
28cowden disease10.0
29gastrointestinal adenoma10.0
30breast adenoma10.0
31cerebellar astrocytoma10.0
32cystic teratoma10.0
33hemangioma10.0
34mediastinitis10.0
35papilloma10.0
36renal adenoma10.0
37renal cell carcinoma10.0
38thyroid adenoma10.0
39prostatitis10.0ACPP
40nasopharyngitis10.0DPP4
41laryngeal squamous cell carcinoma10.0KRT19, MCM2
42oligodendroglioma10.0LGALS3, MCM7
43paraganglioma10.0MEN1, RET
44cervical adenocarcinoma10.0CDKN1B
45graves' disease10.0LGALS3, IL6R
46myeloid leukemia10.0RAP1A
47hyperparathyroidism-jaw tumor syndrome10.0MEN1, RET
48hepatitis10.0CP, DPP4
49ovarian cancer10.0IL6R, CDKN1B
50von hippel-lindau disease10.0RET, MEN1

Graphical network of the top 20 diseases related to Follicular Adenoma:



Diseases related to follicular adenoma

Clinical Features for Follicular Adenoma

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Drugs & Therapeutics for Follicular Adenoma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Follicular Adenoma

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Anatomical Context for Follicular Adenoma

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32MalaCards
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MalaCards organs/tissues related to Follicular Adenoma:

32
Thyroid, Bone, Colon, Breast, Pituitary

Animal Models for Follicular Adenoma or affiliated genes

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36MGI
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Publications for Follicular Adenoma

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50PubMed
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Articles related to Follicular Adenoma:

(show top 50)    (show all 136)
idTitleAuthorsYear
1
Molecular differential diagnosis of follicular thyroid carcinoma and adenoma based on gene expression profiling by using formalin-fixed paraffin-embedded tissues. (24099521)
2013
2
Examination of CD26/DPPIV, p53, and PTEN expression in thyroid follicular adenoma. (22086610)
2012
3
Fine needle aspiration biopsy of an unusual follicular adenoma with sebaceous-like features. (22527948)
2012
4
Genetic studies in a coexistence of acromegaly, pheochromocytoma, gastrointestinal stromal tumor (GIST) and thyroid follicular adenoma. (23295290)
2012
5
Follicular adenoma presenting as lateral aberrant thyroid. (21854673)
2012
6
Comparison of proliferating cell nuclear antigen, thyroid transcription factor-1, Ki-67, p63, p53 and high-molecular weight cytokeratin expressions in papillary thyroid carcinoma, follicular carcinoma, and follicular adenoma. (21315633)
2011
7
Cytologic features of focal papillary thyroid carcinoma arising within follicular adenoma: a masked cytomorphologic analysis of 17 cases. (22156462)
2011
8
Dissecting molecular events in thyroid neoplasia provides evidence for distinct evolution of follicular thyroid adenoma and carcinoma. (21983636)
2011
9
Synchronous occurrence of anaplastic, follicular and papillary carcinomas with follicular adenoma in thyroid gland. (21623114)
2011
10
Kikuchi disease and thyroid follicular adenoma. (20859864)
2010
11
Expression of the sonic hedgehog pathway molecules in synchronous follicular adenoma and papillary carcinoma of the thyroid gland in predicting malignancy. (20797751)
2010
12
A rare case of follicular thyroid carcinoma in a patient with thyrotropin-secreting pituitary adenoma. (19390430)
2009
13
Identification and functional characterization of two novel activating thyrotropin receptor mutants in toxic thyroid follicular adenomas. (19499991)
2009
14
Differential expression of CK 19 in follicular adenoma, well-differentiated tumour of uncertain malignant potential (WDT-UMP) and follicular variant of papillary carcinoma. (19213370)
2009
15
Correspondence between ultrasonography and histological features in a single thyroid nodule with coexisting follicular adenoma and papillary carcinoma. (18631017)
2008
16
Immunohistochemical distinction of follicular thyroid adenomas and follicular carcinomas. (18559722)
2008
17
Immunohistochemical analysis of survivin expression in thyroid follicular adenoma and carcinoma. (17122639)
2006
18
111In-Pentetreotide uptake in a follicular adenoma of the thyroid gland: a pitfall for 111In-Pentetreotide scintigraphy. (17173778)
2006
19
Cell proliferation marker MCM2, but not Ki67, is helpful for distinguishing between minimally invasive follicular carcinoma and follicular adenoma of the thyroid. (16722928)
2006
20
Different genotype distribution of the GNB3 C825T polymorphism of the G protein beta3 subunit in adenomas and differentiated thyroid carcinomas of follicular cell origin. (16178055)
2005
21
A novel loss-of-function deletion in sodium/iodide symporter gene in follicular thyroid adenoma. (16253762)
2005
22
RET and p53 expression in thyroid follicular adenoma: a study of 52 cases with 14 years follow-up. (17191391)
2005
23
Breast carcinoma metastatic to follicular adenoma of the thyroid gland. (15842643)
2005
24
Differentiation of follicular thyroid adenoma from carcinoma by means of gene expression profiling with adapter-tagged competitive polymerase chain reaction. (16319515)
2005
25
Decreased relative expression level of trefoil factor 3 mRNA to galectin-3 mRNA distinguishes thyroid follicular carcinoma from adenoma. (15694668)
2005
26
Diagnostic applicability of dipeptidyl aminopeptidase IV activity in cytological samples for differentiating follicular thyroid carcinoma from follicular adenoma. (14718282)
2004
27
Renal cell carcinoma metastatic to follicular adenoma of the thyroid gland. A case report. (14969183)
2004
28
Spindle cell metaplasia in follicular adenoma of the thyroid gland: case report and review of the literature. (15516778)
2004
29
Is atypical follicular adenoma of the thyroid a preinvasive malignancy? (12874762)
2003
30
A 3.4-kbp transcript of ZNF331 is solely expressed in follicular thyroid adenomas. (14610350)
2003
31
Detection of the PAX8-PPAR gamma fusion oncogene in both follicular thyroid carcinomas and adenomas. (12519876)
2003
32
Spindle cell metaplasia of the thyroid arising in association with papillary carcinoma and follicular adenoma. (11863215)
2002
33
Follicular adenoma with papillary architecture: a lesion mimicking papillary thyroid carcinoma. (11454041)
2001
34
Case report: follicular adenoma in a thyroglossal duct remnant arising entirely within the hyoid bone. (11817294)
2001
35
Fine-structure deletion mapping of 10q22-24 identifies regions of loss of heterozygosity and suggests that sporadic follicular thyroid adenomas and follicular thyroid carcinomas develop along distinct neoplastic pathways. (10534767)
1999
36
Follicular adenoma with squamous metaplasia and cystic change: report of a case with fine needle aspiration cytological and histological features. (11068414)
1999
37
Telomerase activity: a marker to distinguish follicular thyroid adenoma from carcinoma. (9187112)
1997
38
Nuclear area measurements of parathyroid adenoma, parathyroid hyperplasia and thyroid follicular adenoma. A comparison. (9051185)
1997
39
Follicular adenoma of the thyroid gland in children. (8555125)
1995
40
Translocation t(5;19): a recurrent change in thyroid follicular adenoma. (1377944)
1992
41
Karyometric marker features in fine needle aspirates of follicular adenoma of the thyroid. (2206191)
1990
42
Discrimination between follicular adenoma and follicular carcinoma of the thyroid: preoperative validity of cytometry on aspiration smears. (2640896)
1989
43
Expression of keratin 19 distinguishes papillary thyroid carcinoma from follicular carcinomas and follicular thyroid adenoma. (2479256)
1989
44
CT of follicular adenoma in the thyroid gland. (3628854)
1987
45
Differential diagnosis between follicular adenoma and follicular carcinoma of the thyroid by marker features. (2430591)
1986
46
A follicular adenoma with C-cell hyperplasia in the equine thyroid. (6513233)
1984
47
Clinical implications of the rare thyroid carcinoma which is indistinguishable from a follicular adenoma. (727220)
1978
48
Differential diagnosis between follicular adenoma and follicular carcinoma of the thyroid by nuclear DNA determination. (269603)
1977
49
Studies on autoimmunity in thyroid disease. IV. Follicular adenoma. (5588452)
1967
50
PATHOLOGY OF FOLLICULAR THYROID ADENOMA REGARDING MALIGNANT AND REGRESSIVE CHANGES. (14077063)
1963

Genetic Variations for Follicular Adenoma

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Expression for genes affiliated with Follicular Adenoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Follicular Adenoma

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Pathways for genes affiliated with Follicular Adenoma

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49PharmGKB, 53Reactome, 37NCBI BioSystems Database, 29KEGG, 4Cell Signaling Technology
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Compounds for genes affiliated with Follicular Adenoma

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44Novoseek, 24HMDB, 11DrugBank, 59Tocris Bioscience, 49PharmGKB, 28IUPHAR
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Compounds related to Follicular Adenoma according to GeneCards/GeneDecks:

(show top 50)    (show all 51)
idCompoundScoreTop Affiliating Genes
1cycloheximide4410.7DPP4
2estrogen4410.6ACPP
3glycogen44 2411.4PTHLH, IL6R, CDKN1B
4estradiol44 11 2412.4ACPP, PTHLH
5carbohydrates4410.3DPP4, KRT19, CP
6leptomycin b44 5911.3CDKN1B, PTHLH, LGALS3
7paclitaxel44 49 1112.3KRT19, CDKN1B
8heparin44 28 11 2413.2DPP4, CDKN1B, HMGCR, CP
9Alpha-D-Mannose1110.2ACPP, IL6R, DPP4
10sodium dodecylsulfate4410.2CP
11hematoxylin4410.1LGALS3, ACPP, KRT19
12methotrexate44 49 1112.1HMGCR, IL6R, CDKN1B, DPP4
13perillyl alcohol44 2411.0HMGCR, RAP1A
14matrigel4410.0S100A4, DPP4, KRT19, PTHLH, LGALS3
15lovastatin44 49 59 28 1114.0PTHLH, HMGCR, CDKN1B
16vitamin d449.9MEN1, ACPP, PTHLH, LGALS3, CP
17fibrinogen449.9IL6R, KRT19, LGALS3, CP
18epinephrine44 11 2411.9CP, HMGCR, RAP1B, RAPGEF3
19ribonucleic acid449.9RET, IL6R, KRT19, PTHLH
20glutamine449.9CDKN1B, IL6R, RAP1A, LGALS3, CP
21wortmannin449.9CDKN1B, RET, IL6R, RAP1B, LGALS3
22cisplatin44 49 59 1112.8CDKN1B, KRT19, ACPP, PTHLH, LGALS3
23thymidine44 2410.8MEN1, CDKN1B, IL6R, KRT19, ACPP, PTHLH
2412-o-tetradecanoylphorbol 13-acetate449.8CDKN1B, RET, IL6R, RAP1A, PTHLH
25cholesterol44 28 11 2412.7DPP4, CDKN1B, IL6R, HMGCR, ACPP, CP
26glucose449.7CDKN1B, IL6R, RAPGEF3, KRT19, PTHLH
27tartrate449.7PTHLH, ACPP
28aspartate449.7DPP4, RET, KRT19, ACPP, CP
29adenylate449.7DPP4, RAP1A, RAPGEF3, PTHLH, CP
30lactate449.6DPP4, HMGCR, KRT19, ACPP, PTHLH, LGALS3
31creatinine449.6DPP4, IL6R, HMGCR, KRT19, ACPP, PTHLH
32progesterone44 59 28 11 2413.6S100A4, CDKN1B, IL6R, KRT19, ACPP, PTHLH
33oligonucleotide449.5LGALS3, ACPP, IL6R, RET, CDKN1B, S100A4
34oxygen44 2410.5CDKN1B, RAP1A, KRT19, PTHLH, LGALS3, CP
35threonine449.5LGALS3, PTHLH, RAP1A, RET, MCM2, CDKN1B
36ly294002449.5RAP1B, RAP1A, RET, CDKN1B
37testosterone44 59 11 2412.5CDKN1B, RET, IL6R, KRT19, ACPP, PTHLH
38atp44 2810.5DPP4, CDKN1B, RET, KRT19, ACPP, PTHLH
39paraffin449.5CDKN1B, MCM2, RET, KRT19, ACPP, PTHLH
40cyclic amp44 2410.4CDKN1B, RET, RAP1A, RAPGEF3, RAP1B, PTHLH
41agar449.4CDKN1B, RET, RAP1A, ACPP, PTHLH, LGALS3
42alanine449.3DPP4, CDKN1B, MCM2, RET, ACPP, PTHLH
43retinoic acid44 2410.2S100A4, DPP4, CDKN1B, RET, IL6R, KRT19
44serine449.2CSNK1G2, MEN1, CDKN1B, MCM2, RET, HMGCR
45phosphatidylinositol449.2CDKN1B, RET, IL6R, RAP1A, RAPGEF3, RAP1B
46lipid449.1RET, IL6R, RAP1A, HMGCR, ACPP, PTHLH
47arginine449.0CDKN1B, RET, IL6R, RAP1A, HMGCR, ACPP
48vegf448.7CP, MEN1, CDKN1B, RET, IL6R, RAP1A
49calcium44 49 11 2411.5S100A4, MEN1, DPP4, RET, IL6R, RAP1A
50tyrosine448.2MCM7, CDKN1B, DPP4, MEN1, S100A4, RET

GO Terms for genes affiliated with Follicular Adenoma

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16Gene Ontology
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Cellular components related to Follicular Adenoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MCM complexGO:04255510.0MCM7, MCM2
2chromatinGO:0007859.6MCM7, MCM2, MEN1

Biological processes related to Follicular Adenoma according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1DNA unwinding involved in DNA replicationGO:00626810.0MCM2, MCM7
2regulation of cell junction assemblyGO:190188810.0RAP1B, RAP1A
3positive regulation of Rap GTPase activityGO:03285410.0RAPGEF3, RAP1A
4establishment of endothelial barrierGO:0610289.9RAP1B, RAPGEF3, RAP1A
5Rap protein signal transductionGO:0324869.8RAP1B, RAPGEF3, RAP1A
6cellular response to cAMPGO:0713209.8RAP1A, RAPGEF3, RAP1B
7energy reserve metabolic processGO:0061129.7RAP1B, RAPGEF3, RAP1A
8regulation of insulin secretionGO:0507969.4RAP1A, RAPGEF3, RAP1B
9small molecule metabolic processGO:0442818.7CSNK1G2, RAP1A, RAPGEF3, RAP1B, HMGCR, SLC25A32

Molecular functions related to Follicular Adenoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Rap guanyl-nucleotide exchange factor activityGO:0170349.9RAPGEF3, RAP1A
2protein bindingGO:0055157.3LGALS3, S100A4, MEN1, DPP4, CDKN1B, MCM2

Products for genes affiliated with Follicular Adenoma

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Sources for Follicular Adenoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet