MCID: FLL013
MIFTS: 41

Follicular Dendritic Cell Sarcoma malady

Categories: Cancer diseases, Blood diseases, Rare diseases, Immune diseases

Aliases & Classifications for Follicular Dendritic Cell Sarcoma

Aliases & Descriptions for Follicular Dendritic Cell Sarcoma:

Name: Follicular Dendritic Cell Sarcoma 12 12 56 14
Dendritic Cell Sarcoma, Not Otherwise Specified 12 69
Dendritic Cell Sarcoma, Follicular 42 69
Dendritic Cell Sarcoma 12 14
Dendritic Cell Sarcoma Not Otherwise Specified 56
Dendritic Cell Sarcoma, Interdigitating 69
Follicular Dendritic Cell Tumour 12

Characteristics:

Orphanet epidemiological data:

56
follicular dendritic cell sarcoma
Age of onset: All ages;

Classifications:



External Ids:

Disease Ontology 12 DOID:6262 DOID:7849
ICD10 33 C96.4
MeSH 42 D054740
NCIt 47 C9281 C27260
UMLS via Orphanet 70 C1301364 C1260325
ICD10 via Orphanet 34 C96.4
MESH via Orphanet 43 D054740

Summaries for Follicular Dendritic Cell Sarcoma

Disease Ontology : 12 A dendritic cell sarcoma cancer that effects the follicular dendritic cells.

MalaCards based summary : Follicular Dendritic Cell Sarcoma, also known as dendritic cell sarcoma, not otherwise specified, is related to dendritic cell tumor and sarcoma, and has symptoms including fatigue, fever and night sweats. An important gene associated with Follicular Dendritic Cell Sarcoma is CR2 (Complement C3d Receptor 2), and among its related pathways/superpathways are Innate Immune System and RANK Signaling in Osteoclasts. Affiliated tissues include tonsil, lymph node and liver, and related phenotype is Synthetic lethal with vaccinia virus (VACV) infection.

Wikipedia : 71 Follicular dendritic cell sarcoma (FDCS) is an extremely rare neoplasm. While the existence of FDC... more...

Related Diseases for Follicular Dendritic Cell Sarcoma

Diseases related to Follicular Dendritic Cell Sarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 61)
id Related Disease Score Top Affiliating Genes
1 dendritic cell tumor 11.4
2 sarcoma 10.9
3 tonsillitis 10.4
4 pemphigus 10.4
5 paraneoplastic pemphigus 10.3
6 lower clivus meningioma 10.2 CR1 CR2
7 mite infestation 10.2 CR1 CR2
8 cloacogenic carcinoma 10.2 CR1 CR2
9 chronic wasting disease 10.2 CR1 CR2
10 mediastinitis 10.2
11 myasthenia gravis 10.1
12 hormone producing pituitary cancer 10.1 CR2 KIT
13 omodysplasia 2 10.1 CR1 CR2 FCER2
14 jejunal somatostatinoma 10.1 DSP KIT
15 cardiomyopathy, dilated, 1bb 10.1 DSG1 DSP
16 pneumonia caused by pseudomonas aeruginosa infection 10.1 DSG1 DSP
17 peripheral t-cell lymphoma 10.0 DSG1 DSP
18 cecum adenoma 10.0 CR1 CR2 KIT
19 bilateral breast cancer 10.0 CD68 CR2
20 pharyngitis 10.0
21 thyroiditis 10.0
22 castleman disease 10.0
23 atypical autism 10.0 DSG1 DSP
24 lipoma 10.0 DSG1 DSP
25 chondroid lipoma 10.0 CD68 KIT
26 hypoglossal nerve disease 10.0 CD68 KIT
27 acute pulmonary heart disease 10.0 DSG1 DSP
28 freemartinism 10.0 CD68 KIT
29 tibial adamantinoma 10.0 CD68 PPP3CA
30 choriocarcinoma of ovary 9.9 CD68 KIT
31 carotid artery thrombosis 9.9 DSG1 DSP
32 hepatitis 9.9
33 cervicitis 9.9
34 pol iii-related leukodystrophies 9.9 DSG1 DSP
35 cerebral arterial disease 9.9 CD68 KIT
36 teebi naguib al awadi syndrome 9.9 CD68 CR1 CR2
37 monostotic fibrous dysplasia 9.9 CD68 CR1 CR2
38 endodermal sinus tumor 9.9 CD68 KIT
39 adenosquamous colon carcinoma 9.9 CLU CR1 CR2 PPP3CA
40 folinic acid-responsive seizures 9.8 DSG1 DSP
41 nelson syndrome 9.8 CD68 KIT
42 breast cancer 9.8
43 kaposi sarcoma 9.8
44 nasopharyngeal carcinoma 9.8
45 reticulum cell sarcoma 9.8
46 arthritis 9.8
47 leukemia 9.8
48 lymphoma 9.8
49 nasopharyngitis 9.8
50 thymoma 9.8

Graphical network of the top 20 diseases related to Follicular Dendritic Cell Sarcoma:



Diseases related to Follicular Dendritic Cell Sarcoma

Symptoms & Phenotypes for Follicular Dendritic Cell Sarcoma

UMLS symptoms related to Follicular Dendritic Cell Sarcoma:


fatigue, fever, night sweats

GenomeRNAi Phenotypes related to Follicular Dendritic Cell Sarcoma according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with vaccinia virus (VACV) infection GR00362-A 8.92 CD68 CLU DSG1 PPP3CA

Drugs & Therapeutics for Follicular Dendritic Cell Sarcoma

Search Clinical Trials , NIH Clinical Center for Follicular Dendritic Cell Sarcoma

Cochrane evidence based reviews: dendritic cell sarcoma, follicular

Genetic Tests for Follicular Dendritic Cell Sarcoma

Anatomical Context for Follicular Dendritic Cell Sarcoma

MalaCards organs/tissues related to Follicular Dendritic Cell Sarcoma:

39
Tonsil, Lymph Node, Liver, Spleen, T Cells, Colon, Brain

Publications for Follicular Dendritic Cell Sarcoma

Articles related to Follicular Dendritic Cell Sarcoma:

(show top 50) (show all 195)
id Title Authors Year
1
Cytological features of inflammatory pseudotumor-like follicular dendritic cell sarcoma of spleen: A case report. ( 27775241 )
2016
2
Follicular dendritic cell sarcoma of the spleen: A case report and review of the literature. ( 27602139 )
2016
3
Response to rituximab in an anti-muscle-specific receptor tyrosine kinase- and anti-acetylcholine recepto-double-positive myasthenia gravis patient concomitant with follicular dendritic cell sarcoma. ( 26818174 )
2016
4
Extranodal Follicular Dendritic Cell Sarcoma Originating in the Pancreas: A Case Report. ( 27082603 )
2016
5
Poster 10 Successful Rehabilitation Outcome from Rare Brain Tumor (Intracranial Follicular Dendritic Cell Sarcoma): A Case Report. ( 27672780 )
2016
6
Clinicopathological Profile and Outcomes of Follicular Dendritic Cell Sarcoma of the Head and Neck Region - A Study of 10 Cases with Literature Review. ( 27656545 )
2016
7
Clinicopathological characteristics of mediastinal follicular dendritic cell sarcoma: report of three cases. ( 27068522 )
2016
8
MDM2 Expression in Extranodal Abdominal and Retroperitoneal Follicular Dendritic Cell Sarcomas, Mimicking Dedifferentiated Liposarcomas. ( 26180935 )
2016
9
Follicular dendritic cell tumour/sarcoma: a commonly misdiagnosed tumour in the thorax Intrathoracic follicular dendritic cell sarcoma. ( 27206572 )
2016
10
Computer Tomography Imaging Findings of Abdominal Follicular Dendritic Cell Sarcoma: A Report of 5 Cases. ( 26735543 )
2016
11
Paraneoplastic pemphigus and myasthenia gravis, associated with inflammatory pseudotumor-like follicular dendritic cell sarcoma: response to rituximab. ( 27525088 )
2016
12
(18)F-FDG PET/CT follow-up of follicular dendritic cell sarcoma. ( 27793634 )
2016
13
Follicular Dendritic Cell Sarcoma. ( 26910224 )
2016
14
Treatment of breast cancer 2 (BRCA2)-mutant follicular dendritic cell sarcoma with a poly ADP-ribose polymerase (PARP) inhibitor: a case report. ( 27488020 )
2016
15
Completely resected follicular dendritic cell sarcoma of the posterior mediastinum: report of a case. ( 27001632 )
2016
16
Follicular Dendritic Cell Sarcoma of Appendix Presenting as Acute Appendicitis: An Exceptionally Rare Case Report. ( 27225654 )
2016
17
Follicular dendritic cell sarcoma: clinicopathologic study of 15 cases with emphasis on novel expression of MDM2, somatostatin receptor 2A, and PD-L1. ( 27402219 )
2016
18
A Rare Case of Epstein-Barr Virus Negative Inflammatory Pseudotumor-like Follicular Dendritic Cell Sarcoma Presenting as a Solitary Colonic Mass in a 53-Year-Old Woman; Case Report and Review of Literature. ( 27299190 )
2016
19
High efficacy of tumor-targeting Salmonella typhimurium A1-R on a doxorubicin- and dactolisib-resistant follicular dendritic-cell sarcoma in a patient-derived orthotopic xenograft PDOX nude mouse model. ( 27105519 )
2016
20
Follicular dendritic cell sarcoma treated with a variety of chemotherapy. ( 27734516 )
2016
21
Synchronous presentation of intra-nodal follicular dendritic cell sarcoma and Castleman disease. ( 27862216 )
2016
22
Paraneoplastic arthritis as first symptom of a liver inflammatory pseudotumor-like follicular dendritic cell sarcoma. ( 27125361 )
2016
23
Follicular dendritic cell sarcoma of the right tonsil: A case report and literature review. ( 25621026 )
2015
24
Follicular dendritic cell sarcoma: two rare cases and a brief review of the literature. ( 26244020 )
2015
25
Retroperitoneal and mediastinal follicular dendritic cell sarcoma: report of 3 cases with review of literature. ( 26639109 )
2015
26
Follicular dendritic cell sarcoma of the tonsil. ( 25512260 )
2015
27
Targeted genomic sequencing of follicular dendritic cell sarcoma reveals recurrent alterations in NF-I_B regulatory genes. ( 26564005 )
2015
28
Follicular dendritic cell sarcoma with extensive lymph node involvement: A case report. ( 26171038 )
2015
29
Clinical and pathological features of head and neck follicular dendritic cell sarcoma. ( 25831474 )
2015
30
Extranodal follicular dendritic cell sarcoma involving tonsil. ( 26712678 )
2015
31
High-risk follicular dendritic cell sarcoma of the tonsil mimicking nasopharyngeal carcinoma. ( 27003778 )
2015
32
Follicular dendritic cell sarcoma of mediastinum: a key role of radiotherapy in a multidisciplinary approach. ( 26638926 )
2015
33
Extranodal follicular dendritic cell sarcoma: A clinicopathological report of four cases and a literature review. ( 25435998 )
2015
34
Resection is an effective treatment for recurrent follicular dendritic cell sarcoma from retroperitoneum: unusual presentation of a rare tumor. ( 26221397 )
2015
35
Follicular Dendritic Cell Sarcoma: Cytogenetics and pathological findings. ( 26355964 )
2015
36
Extranodal follicular dendritic cell sarcoma: a frequently misdiagnosed entity. ( 25511225 )
2015
37
Follicular dendritic cell sarcoma of the head and neck: Case report, literature review, and pooled analysis of 97 cases. ( 25917851 )
2015
38
A rare case of follicular dendritic cell sarcoma with pseudochylous effusion and review of literature from India. ( 25825580 )
2015
39
Paraneoplastic pemphigus associated with follicular dendritic cell sarcoma: report of a case and review of literature. ( 26722384 )
2015
40
Intraperitoneal follicular dendritic cell sarcoma: role of chemotherapy and bone marrow allotransplantation in locally advanced disease? ( 25698886 )
2015
41
Follicular dendritic cell sarcoma with atypical features surrounding undescended testis: description of a rare case. ( 25889780 )
2015
42
Follicular Dendritic Cell Sarcoma of Lymph Node: A report of a Patient with Chronic Myeloid Leukemia Treated with Imatinib. ( 26261702 )
2015
43
FDG PET/CT in follicular dendritic cell sarcoma with extensive peritoneal involvement. ( 24476636 )
2014
44
Response of follicular dendritic cell sarcoma to gemcitabine and docetaxel: report of two cases and literature review. ( 25009738 )
2014
45
Paraneoplastic pemphigus as the first manifestation of follicular dendritic cell sarcoma. ( 24119156 )
2014
46
Follicular Dendritic Cell Sarcoma of the Inflammatory Pseudotumor-like Variant Presenting as a Colonic Polyp. ( 24868227 )
2014
47
Recalcitrant paraneoplastic pemphigus associated with follicular dendritic cell sarcoma: response to prolonged rituximab and ciclosporin therapy. ( 25367731 )
2014
48
Follicular Dendritic Cell Sarcoma Presenting As a Thyroid Mass. ( 24663046 )
2014
49
Long term survival after whole brain radiotherapy for brain metastasis in follicular dendritic cell sarcoma. ( 25494162 )
2014
50
Mediastinal follicular dendritic cell sarcoma with paraneoplastic pemphigus. ( 25406405 )
2014

Variations for Follicular Dendritic Cell Sarcoma

Expression for Follicular Dendritic Cell Sarcoma

Search GEO for disease gene expression data for Follicular Dendritic Cell Sarcoma.

Pathways for Follicular Dendritic Cell Sarcoma

GO Terms for Follicular Dendritic Cell Sarcoma

Cellular components related to Follicular Dendritic Cell Sarcoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 membrane GO:0016020 9.97 CD68 CLU CR1 CR2 DSG1 DSP
2 extracellular exosome GO:0070062 9.88 CLU CR1 CR2 DSG1 DSP FCER2
3 extracellular matrix GO:0031012 9.61 CLU DSG1 DSP
4 plasma membrane GO:0005886 9.56 CD68 CR1 CR2 DSG1 DSP FCER2
5 cornified envelope GO:0001533 9.46 DSG1 DSP
6 cytoplasmic side of plasma membrane GO:0009898 9.37 DSG1 KIT
7 cell-cell junction GO:0005911 9.33 DSG1 DSP KIT
8 desmosome GO:0030057 9.26 DSG1 DSP
9 ficolin-1-rich granule membrane GO:0101003 8.8 CR1 DSG1 DSP

Biological processes related to Follicular Dendritic Cell Sarcoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 neutrophil degranulation GO:0043312 9.56 CD68 CR1 DSG1 DSP
2 positive regulation of gene expression GO:0010628 9.5 CLU KIT PPP3CA
3 complement activation, classical pathway GO:0006958 9.33 CLU CR1 CR2
4 complement receptor mediated signaling pathway GO:0002430 8.96 CR1 CR2
5 regulation of complement activation GO:0030449 8.8 CLU CR1 CR2

Sources for Follicular Dendritic Cell Sarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
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42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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