MCID: FLL013
MIFTS: 45

Follicular Dendritic Cell Sarcoma malady

Blood, Cancer categories

Summaries for Follicular Dendritic Cell Sarcoma

Sources:
8Disease Ontology, 64Wikipedia, 33MalaCards
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Wikipedia:64 Follicular Dendritic Cell Sarcoma (FDCS) is an extremely rare neoplasm. While the existence of FDC... more...

MalaCards: Follicular Dendritic Cell Sarcoma, also known as dendritic cell sarcoma, follicular, is related to castleman's disease and pemphigus. An important gene associated with Follicular Dendritic Cell Sarcoma is EVPL (envoplakin), and among its related pathways are Immune response Lectin induced complement pathway and Cell adhesion Endothelial cell contacts by junctional mechanisms. The compounds cycloheximide and cr2+ have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, lymph node and spleen, and related mouse phenotypes are immune system and cellular.

Disease Ontology:8 A dendritic cell cancer and histiocytosis that effects the follicular dendritic cells.

Aliases & Classifications for Follicular Dendritic Cell Sarcoma

Sources:
8Disease Ontology, 10DISEASES, 49Orphanet, 61UMLS, 35MeSH, 57SNOMED-CT, 40NCIt, 36MESH via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet, 26ICD10 via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Blood


Characteristics (Orphanet epidemiological data):

49
follicular dendritic cell sarcoma:
Age of onset: Variable


Aliases & Descriptions:

follicular dendritic cell sarcoma 8 10 49
dendritic cell sarcoma, follicular 61
follicular dendritic cell tumour 8


External Ids:

Disease Ontology8 DOID:6262
MeSH35 D054740
NCIt40 C9281
MESH via Orphanet36 D054740
SNOMED-CT57 128816008
SNOMED-CT via Orphanet58 128816008
UMLS via Orphanet62 C1260325
ICD10 via Orphanet26 C96.4

Related Diseases for Follicular Dendritic Cell Sarcoma

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Follicular Dendritic Cell Sarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 111)
idRelated DiseaseScoreTop Affiliating Genes
1castleman's disease31.1FSCN1, DSG3
2pemphigus31.0PPL, DSP, DSG3, DSG1, EVPL
3thymoma30.4PPL, DSP, EVPL
4follicular lymphoma30.4CR2, CR1, FCER2
5paraneoplastic pemphigus10.7
6follicular dendritic cell tumor10.7
7vascular disease10.5
8interdigitating dendritic cell sarcoma10.4
9thyroid sarcoma10.4
10pancreas sarcoma10.3
11cellulitis10.3
12liver inflammatory pseudotumor10.3
13kaposi's sarcoma10.3
14small cell sarcoma10.3
15amyloidosis10.3
16thyroiditis10.3
17amyloidosis, secondary10.3
18lymphoma, diffuse large cell10.3
19bronchiolitis10.0FCER2
20cystadenoma10.0CLU
21keratoacanthoma10.0DSG3
22pemphigus vegetans10.0DSG1
23epidermolysis bullosa acquisita10.0DSG1
24lichen planus10.0DSG3
25bullous impetigo10.0DSG1
26bronchiolitis obliterans10.0PPL
27epidermolysis bullosa10.0DSP
28subcorneal pustular dermatosis10.0DSG1
29silicosis10.0DSG1
30hailey-hailey disease10.0DSP
31inverted papilloma10.0FSCN1
32atherosclerosis10.0CLU
33ritter's disease10.0DSG1
34pleurisy10.0IL2RA
35choroid plexus papilloma10.0TP53
36gallbladder cancer10.0TP53
37benign meningioma10.0SLC2A1
38kidney cancer10.0TP53
39mastocytosis10.0IL2RA
40hemangioblastoma10.0SLC2A1
41histiocytosis10.0FSCN1
42myasthenia gravis10.0CR1
43hepatitis10.0CR1
44esophageal cancer10.0TP53
45herpes simplex10.0CR1
46dermatitis10.0DSG3, DSG1
47liver cirrhosis10.0CR1
48nephroblastoma10.0TP53
49psoriasis10.0IL2RA, FCER2
50malignant fibroxanthoma10.0TP53

Graphical network of the top 20 diseases related to Follicular Dendritic Cell Sarcoma:



Diseases related to follicular dendritic cell sarcoma

Clinical Features for Follicular Dendritic Cell Sarcoma

Drugs & Therapeutics for Follicular Dendritic Cell Sarcoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Follicular Dendritic Cell Sarcoma

Drug clinical trials:

Search ClinicalTrials for Follicular Dendritic Cell Sarcoma

Search NIH Clinical Center for Follicular Dendritic Cell Sarcoma

Search CenterWatch for Follicular Dendritic Cell Sarcoma

Genetic Tests for Follicular Dendritic Cell Sarcoma

Anatomical Context for Follicular Dendritic Cell Sarcoma

Sources:
33MalaCards
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MalaCards organs/tissues related to Follicular Dendritic Cell Sarcoma:

33
Bone marrow, Lymph node, Spleen, Small intestine, Colon, Liver, Lung, Pancreas, Thyroid, Breast, Tonsil, T cells, Appendix

Animal Models for Follicular Dendritic Cell Sarcoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Follicular Dendritic Cell Sarcoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053876.7CR2, DSG3, CLU, CXCL13, IL2RA, FSCN1
2MP:00053845.6TP53, VIM, CR2, SNCG, DSP, DSG3

Publications for Follicular Dendritic Cell Sarcoma

Sources:
51PubMed
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Articles related to Follicular Dendritic Cell Sarcoma:

(show top 50)    (show all 141)
idTitleAuthorsYear
1
Transformation of Castleman's disease into follicular dendritic cell sarcoma, presenting as an asymptomatic intra-abdominal mass. (23981949)
2013
2
Cytogenetic abnormalities in follicular dendritic cell sarcoma: report of two cases and literature review. (23422480)
2013
3
Follicular dendritic cell sarcoma of the tonsil. (23415609)
2013
4
Intraabdominal follicular dendritic cell sarcoma: a report of three cases and review of the literature. (23748832)
2013
5
Pediatric follicular dendritic cell sarcoma of the head and neck: a case report and review of the literature. (23684177)
2013
6
Paraneoplastic pemphigus with anti-laminin-332 autoantibodies in a patient with follicular dendritic cell sarcoma. (23324777)
2013
7
Pathology quiz case 1. Follicular dendritic cell sarcoma (FDS). (22801898)
2012
8
Extranodal follicular dendritic cell sarcoma with rapid growth in parapharynx: a case report. (23110021)
2012
9
Follicular dendritic cell sarcoma of the tonsil. (23251062)
2012
10
Follicular Dendritic Cell Sarcoma of the Head and Neck Expressing Thyroid Transcription Factor-1: A Case Report With Clinicopathologic and Immunohistochemical Literature Review. (21836499)
2012
11
Follicular dendritic cell sarcoma of the liver: unusual presentation of a rare tumor and literature review. (21813397)
2011
12
Imaging findings of follicular dendritic cell sarcoma: report of four cases. (21228948)
2011
13
Follicular dendritic cell sarcoma and associated myasthenia gravis: true, true, related? (21321294)
2011
14
Follicular dendritic cell sarcoma of the neck with pulmonary metastases. (21914416)
2011
15
Follicular dendritic cell sarcoma of the tonsil. (20499431)
2010
16
Extranodal follicular dendritic cell sarcoma of the pharyngeal region: a potential diagnostic pitfall, with literature review. (20023258)
2010
17
A follicular dendritic cell sarcoma of the mediastinum with immature T cells and association with myasthenia gravis. (20305533)
2010
18
Follicular dendritic cell sarcoma/tumor: 2 cases of a rare tumor of difficult clinical and pathological diagnosis. (19608084)
2009
19
Clonally related follicular lymphomas and histiocytic/dendritic cell sarcomas: evidence for transdifferentiation of the follicular lymphoma clone. (18272816)
2008
20
Extranodal follicular dendritic cell sarcoma. (18834231)
2008
21
Follicular dendritic cell sarcoma of the nasopharynx. (18598838)
2008
22
Follicular dendritic cell sarcoma: a case report. (18500003)
2008
23
Intra-abdominal follicular dendritic cell sarcoma with marked pleomorphic features and aberrant expression of neuroendocrine markers: report of a case with immunohistochemical analysis. (17721283)
2007
24
Follicular dendritic cell sarcoma of the tonsil: a case report and literature review. (17500398)
2007
25
Follicular dendritic cell sarcoma: a report of 14 cases and a review of the literature. (17373675)
2007
26
Follicular dendritic cell sarcoma: a rare tumor presenting as an abdominal mass. (17652548)
2007
27
Follicular dendritic cell sarcoma of lymph node--a rare entity. (16696516)
2006
28
Follicular dendritic cell sarcoma of the tonsil: case report. (16896752)
2006
29
Retroperitoneal follicular dendritic cell sarcoma. (16867894)
2006
30
Intra-abdominal follicular dendritic cell sarcoma. (17134976)
2006
31
Follicular dendritic cell sarcoma arising in the dura mater of the spine. (17076538)
2006
32
Autoantibody production from a thymoma and a follicular dendritic cell sarcoma associated with paraneoplastic pemphigus. (16120143)
2005
33
A survey of clusterin and fascin expression in sarcomas and spindle cell neoplasms: strong clusterin immunostaining is highly specific for follicular dendritic cell tumor. (15467709)
2005
34
Fine-needle aspiration cytology of a liver metastasis of follicular dendritic cell sarcoma. (15584048)
2005
35
Metastatic follicular dendritic cell sarcoma of the stomach: a case report and review of the literature. (15285580)
2004
36
Epidermal growth factor receptor expression in follicular dendritic cells: a shared feature of follicular dendritic cell sarcoma and Castleman's disease. (14562277)
2003
37
Two cases of extranodal follicular dendritic cell sarcoma. (12875705)
2003
38
Follicular dendritic cell sarcoma of the tonsil: report of a rare case. (12955835)
2003
39
Follicular dendritic cell sarcoma of the neck; a case report and literature review. (12393051)
2002
40
Follicular dendritic cell sarcoma of the omentum. (12070608)
2002
41
Follicular dendritic cell sarcoma of the breast. (12189511)
2002
42
Follicular dendritic cell sarcoma of the colon mimicking stromal tumour. (11135043)
2001
43
Follicular dendritic cell sarcoma: ultrastructural and immunohistochemical studies. (11065250)
2000
44
Fine needle aspiration cytology of follicular dendritic cell sarcoma. A case report. (11127744)
2000
45
Follicular dendritic cell sarcoma presenting as a submucosal tumor of the stomach. (11079028)
2000
46
Extranodal follicular dendritic cell sarcoma of the palate. (10052377)
1999
47
Paraneoplastic pemphigus associated with follicular dendritic cell sarcoma arising from Castleman's tumor. (10025851)
1999
48
Follicular dendritic cell sarcoma mimicking diffuse large cell lymphoma: a case report. (9256295)
1997
49
Extranodal follicular dendritic cell sarcoma of the gastrointestinal tract. Morphologic, immunohistochemical and ultrastructural analysis of two cases. (7817952)
1995
50
Immunophenotypic analysis of neoplastic cells in follicular dendritic cell sarcoma. (3312845)
1987

Genetic Variations for Follicular Dendritic Cell Sarcoma

Expression for genes affiliated with Follicular Dendritic Cell Sarcoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Follicular Dendritic Cell Sarcoma

Search GEO for disease gene expression data for Follicular Dendritic Cell Sarcoma.

Pathways for genes affiliated with Follicular Dendritic Cell Sarcoma

Sources:
12EMD Millipore, 54Reactome, 30KEGG
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Compounds for genes affiliated with Follicular Dendritic Cell Sarcoma

Sources:
45Novoseek, 2BitterDB, 60Tocris Bioscience, 50PharmGKB, 29IUPHAR, 11DrugBank, 24HMDB
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Compounds related to Follicular Dendritic Cell Sarcoma according to GeneCards/GeneDecks:

(show all 33)
idCompoundScoreTop Affiliating Genes
1cycloheximide4510.5CR1
2cr2+4510.3CR2, CR1
3mycophenolate sodium4510.2CR1, IL2RA
4aristolochic acid45 211.1VIM
5okt34510.1FCER2, IL2RA, CR2
6asulam4510.0PPL, DSP
7tunicamycin45 6011.0SLC2A1, FCER2, CLU
8cytochalasin b459.9SLC2A1, FCER2, VIM
9dexamethasone45 50 29 1112.9SLC2A1, FCER2, CLU
10toxin a459.8DSG1, DSG3
11paclitaxel45 50 1111.7TP53, CLU, SNCG
12calcitriol45 60 11 2412.7CLU, IL2RA, FCER2, SLC2A1
13ivig459.6DSG3, DSG1, IL2RA
14formaldehyde45 2410.6VIM, CR1, IL2RA, FCER2
15heparin45 29 11 2412.6SLC2A1, IL2RA, CLU, CR1
16cytarabine45 50 1111.5VIM, CR1, TP53
17vincristine45 50 1111.5TP53, IL2RA, VIM
18vitamin d459.5VIM, CR1, CLU, IL2RA
19etoposide45 50 60 1112.4VIM, CLU, IL2RA, TP53
2012-o-tetradecanoylphorbol 13-acetate459.3VIM, DSP, FSCN1, FCER2
215-aza-2deoxycytidine459.3VIM, SNCG, CLU, TP53
22doxorubicin45 50 1111.3VIM, CLU, IL2RA, TP53
23prednisolone45 29 1111.2IL2RA, DSG3, CR1
24actinomycin d459.2VIM, CLU, SLC2A1, TP53
25acetylcholine45 50 29 11 2413.1VIM, DSG3, DSG1, IL2RA
26genistein45 29 60 2 11 2414.0SLC2A1, FCER2, IL2RA, VIM
27vegf458.7VIM, CLU, IL2RA, SLC2A1, TP53
28estrogen458.5VIM, CR2, SNCG, CLU, IL2RA, SLC2A1
29serine458.4DSP, DSG3, DSG1, CLU, FSCN1, FCER2
30retinoic acid45 249.2VIM, CR1, DSP, DSG1, CLU, FSCN1
31paraffin457.9TP53, VIM, CR2, CR1, CLU, IL2RA
32tyrosine457.3DSP, SNCG, CR1, CR2, DSG3, CLU
33calcium45 50 11 249.6CR2, CR1, SNCG, DSP, DSG3, DSG1

GO Terms for genes affiliated with Follicular Dendritic Cell Sarcoma

Sources:
16Gene Ontology
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Cellular components related to Follicular Dendritic Cell Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1desmosomeGO:0300578.3EVPL, DSG1, DSG3, DSP, PPL
2plasma membraneGO:0058866.5SNCG, CR1, CR2, PPL, DSP, DSG3

Biological processes related to Follicular Dendritic Cell Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cellular response to glucose starvationGO:0421499.7TP53, SLC2A1
2intermediate filament organizationGO:0451099.7VIM, DSP
3complement activation, classical pathwayGO:0069589.6CLU, CR1, CR2
4cellular component disassembly involved in execution phase of apoptosisGO:0069219.0DSG1, DSG3, DSP, VIM
5apoptotic processGO:0069158.3IL2RA, DSG1, DSG3, DSP, VIM

Molecular functions related to Follicular Dendritic Cell Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1structural constituent of cytoskeletonGO:0052009.3DSP, PPL, VIM
2protein binding, bridgingGO:0306749.2EVPL, FSCN1, DSP

Products for genes affiliated with Follicular Dendritic Cell Sarcoma

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Sources for Follicular Dendritic Cell Sarcoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet