MCID: FLL013
MIFTS: 51

Follicular Dendritic Cell Sarcoma malady

Blood diseases, Cancer diseases categories

Summaries for Follicular Dendritic Cell Sarcoma

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Wikipedia:63 Follicular Dendritic Cell Sarcoma (FDCS) is an extremely rare neoplasm. While the existence of FDC... more...

MalaCards: Follicular Dendritic Cell Sarcoma, also known as dendritic cell sarcoma, follicular, is related to sarcoma and pemphigus. An important gene associated with Follicular Dendritic Cell Sarcoma is EVPL (envoplakin), and among its related pathways are Immune response Lectin induced complement pathway and Cell adhesion Endothelial cell contacts by junctional mechanisms. The compounds cycloheximide and cr2+ have been mentioned in the context of this disorder. Affiliated tissues include tonsil, lymph node and liver, and related mouse phenotypes are immune system and cellular.

Disease Ontology:8 A dendritic cell cancer and histiocytosis that effects the follicular dendritic cells.

Aliases & Classifications for Follicular Dendritic Cell Sarcoma

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8Disease Ontology, 10DISEASES, 48Orphanet, 60UMLS, 34MeSH, 56SNOMED-CT, 39NCIt, 35MESH via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 26ICD10 via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Blood diseases


Characteristics (Orphanet epidemiological data):

48
follicular dendritic cell sarcoma:
Age of onset: Variable


Aliases & Descriptions:

follicular dendritic cell sarcoma 8 10 48
dendritic cell sarcoma, follicular 60
follicular dendritic cell tumour 8


External Ids:

Disease Ontology8 DOID:6262
MeSH34 D054740
NCIt39 C9281
MESH via Orphanet35 D054740
SNOMED-CT56 128816008
SNOMED-CT via Orphanet57 128816008
UMLS via Orphanet61 C1260325
ICD10 via Orphanet26 C96.4

Related Diseases for Follicular Dendritic Cell Sarcoma

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17GeneCards, 18GeneDecks
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Diseases related to Follicular Dendritic Cell Sarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 122)
idRelated DiseaseScoreTop Affiliating Genes
1sarcoma31.9TP53, FSCN1, CR2, VIM, DSG1, PPL
2pemphigus31.0DSP, DSG3, PPL, DSG1, EVPL
3myasthenia gravis30.7CR1
4hepatitis30.6CR1
5thymoma30.3PPL, DSP, EVPL
6dendritic cell sarcoma11.3
7tonsillitis10.7
8liver sarcoma10.6
9pharyngitis10.5
10vascular disease10.5
11interdigitating dendritic cell sarcoma10.4
12breast sarcoma10.4
13cervicitis10.4
14lung sarcoma10.4
15mediastinitis10.4
16mediastinum sarcoma10.4
17retroperitoneal sarcoma10.4
18thyroid sarcoma10.4
19thyroiditis10.4
20pancreas sarcoma10.2
21epstein-barr virus hepatitis10.2
22cellulitis10.2
23liver inflammatory pseudotumor10.2
24small cell sarcoma10.2
25amyloidosis10.2
26colon sarcoma10.2
27dendritic cell thymoma10.2
28epithelioid sarcoma10.2
29small intestinal sarcoma10.2
30follicular dendritic cell tumor10.2
31bronchiolitis10.0FCER2
32cystadenoma10.0CLU
33keratoacanthoma10.0DSG3
34pemphigus vegetans10.0DSG1
35epidermolysis bullosa acquisita10.0DSG1
36lichen planus10.0DSG3
37bullous impetigo10.0DSG1
38bronchiolitis obliterans10.0PPL
39epidermolysis bullosa10.0DSP
40subcorneal pustular dermatosis10.0DSG1
41silicosis10.0DSG1
42hailey-hailey disease10.0DSP
43inverted papilloma10.0FSCN1
44atherosclerosis10.0CLU
45ritter's disease10.0DSG1
46pleurisy10.0IL2RA
47choroid plexus papilloma10.0TP53
48gallbladder cancer10.0TP53
49benign meningioma10.0SLC2A1
50kidney cancer10.0TP53

Graphical network of the top 20 diseases related to Follicular Dendritic Cell Sarcoma:



Diseases related to follicular dendritic cell sarcoma

Clinical Features for Follicular Dendritic Cell Sarcoma

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Drugs & Therapeutics for Follicular Dendritic Cell Sarcoma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Follicular Dendritic Cell Sarcoma

Drug clinical trials:

Search ClinicalTrials for Follicular Dendritic Cell Sarcoma

Search NIH Clinical Center for Follicular Dendritic Cell Sarcoma

Search CenterWatch for Follicular Dendritic Cell Sarcoma

Genetic Tests for Follicular Dendritic Cell Sarcoma

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Anatomical Context for Follicular Dendritic Cell Sarcoma

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32MalaCards
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MalaCards organs/tissues related to Follicular Dendritic Cell Sarcoma:

32
Tonsil, Lymph node, Liver, Bone, Spleen, T cells, Lung, Breast, Thyroid, Pancreas, Bone marrow, Colon, Small intestine, Appendix

Animal Models for Follicular Dendritic Cell Sarcoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Follicular Dendritic Cell Sarcoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053876.7CR2, DSG3, CLU, CXCL13, IL2RA, FSCN1
2MP:00053845.6TP53, VIM, CR2, SNCG, DSP, DSG3

Publications for Follicular Dendritic Cell Sarcoma

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50PubMed
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Articles related to Follicular Dendritic Cell Sarcoma:

(show top 50)    (show all 141)
idTitleAuthorsYear
1
Inflammatory pseudotumor-like follicular dendritic cell sarcoma of the spleen: a report of six cases with increased IgG4-positive plasma cells. (23714251)
2013
2
Follicular dendritic cell sarcoma associated with hyaline-vascular Castleman's disease. (23914648)
2013
3
Interdigitating dendritic cell sarcoma and follicular dendritic cell sarcoma : histopathological findings for differential diagnosis. (24369219)
2013
4
Follicular dendritic cell sarcoma of the omentum: multidetector computed tomography findings. (23483068)
2013
5
Follicular dendritic cell sarcoma of the pharyngeal region. (23761812)
2013
6
Follicular dendritic cell sarcoma of the tonsil. (23365157)
2013
7
Follicular dendritic cell sarcoma: a diagnostic challenge ! (22842383)
2012
8
F-18 FDG PET/CT imaging of follicular dendritic cell sarcoma of the mediastinum. (22228355)
2012
9
Follicular dendritic cell sarcoma of the nasopharynx. (21835593)
2012
10
Spontaneous regression of follicular dendritic cell sarcoma. (22162586)
2012
11
I^-Synuclein is a promising new marker for staining reactive follicular dendritic cells, follicular dendritic cell sarcoma, Kaposi sarcoma, and benign and malignant vascular tumors. (21959308)
2011
12
Follicular dendritic cell sarcoma of the lung: a report of two cases highlighting its pathological features and diagnostic pitfalls. (21240069)
2011
13
Cervical follicular dendritic cell sarcoma: a case report and review of the literature. (21658332)
2011
14
Primary follicular dendritic cell sarcoma of liver treated with cyclophosphamide, doxorubicin, vincristine, and prednisone regimen and surgery. (22042944)
2011
15
Extranodal follicular dendritic cell sarcoma in mesentery: A case report. (22848243)
2011
16
Follicular dendritic cell sarcoma with immature T-cell proliferation. (19740517)
2010
17
Follicular dendritic cell sarcoma of tonsil. (20141695)
2010
18
Follicular dendritic cell sarcoma with microtubuloreticular structure and virus-like particle production in vitro. (19432677)
2009
19
Clinical and pathological features of follicular dendritic cell sarcoma of appendix: a case report. (19719956)
2009
20
SIR 2008 annual meeting film panel case: Castleman disease complicated by follicular dendritic cell sarcoma. (18656005)
2008
21
Cytogenetic abnormality 46,XX,add(21)(q11.2) in a patient with follicular dendritic cell sarcoma. (18786443)
2008
22
Follicular dendritic cell sarcoma of the head and neck: case report and literature review. (18596475)
2008
23
Expression of Glut-1 and Claudin-1 in follicular dendritic cell sarcoma. (18227718)
2008
24
Paraneoplastic pemphigus associated with follicular dendritic cell sarcoma without Castleman's disease; treatment with rituximab. (18477166)
2008
25
Cytopathology of a primary follicular dendritic cell sarcoma of the liver of the inflammatory pseudotumor-like type. (18064686)
2008
26
Follicular dendritic cell sarcoma of inguinal lymph node--a case report. (19291921)
2008
27
Clinicopathologic study of intraabdominal extranodal follicular dendritic cell sarcoma]. (18194598)
2007
28
Follicular dendritic cell sarcoma of oral cavity: report of 2 cases. (17883129)
2007
29
Nodal follicular dendritic cell sarcoma of the axilla presenting as cellulitis. (16403115)
2006
30
Follicular dendritic cell sarcoma mimicking giant cell carcinoma of the pancreas. (16872443)
2006
31
Primary follicular dendritic cell sarcoma of the lung. (16978210)
2006
32
Mediastinal follicular dendritic cell sarcoma involving bone marrow: a case report and review of the literature. (17126255)
2006
33
Follicular dendritic cell sarcoma of the tonsil: a case report. (16647987)
2006
34
Follicular dendritic cell sarcoma in pregnancy: case report and review of the literature. (17094047)
2006
35
Paraneoplastic pemphigus associated with follicular dendritic cell sarcoma and Castleman disease. (16029358)
2005
36
Parotid gland carcinosarcoma with follicular dendritic cell sarcoma as mesenchymal component: a case report. (15788137)
2005
37
Follicular dendritic cell sarcoma of the soft palate. (16496065)
2005
38
Hepatic follicular dendritic cell sarcoma without Epstein-Barr virus expression. (16253031)
2005
39
Follicular dendritic cell sarcoma arising from the hypopharynx. (15117477)
2004
40
Follicular dendritic cell sarcoma of the pharyngeal region: histologic, cytologic, immunohistochemical, and ultrastructural study of three cases. (15614735)
2004
41
Follicular dendritic cell sarcoma of a cervical lymph node: case report and review of the literature. (15724745)
2004
42
Intracranial follicular dendritic cell sarcoma. Case report. (14705740)
2003
43
Mediastinal follicular dendritic cell sarcoma. (12604428)
2003
44
Development of follicular dendritic cell sarcoma in hyaline-vascular Castleman's disease of the nasopharynx: tracing its evolution by sequential biopsies. (11422494)
2001
45
Intraabdominal follicular dendritic cell sarcoma: report of a case with fine needle aspiration findings. (11726132)
2001
46
Retroperitoneal follicular dendritic cell sarcoma presenting as secondary amyloidosis. (11436023)
2001
47
Fine needle aspiration cytology of follicular dendritic cell sarcoma. Report of a case with cytologic detection in an extranodal site. (11015984)
2000
48
Follicular dendritic cell sarcoma of the neck: report of two cases complicated by pulmonary metastases. (10931467)
2000
49
Follicular dendritic cell sarcoma of lymph node. (10772016)
2000
50
Follicular dendritic cell sarcoma complicated by hyaline-vascular type Castleman's disease in a schizophrenic patient. (9361105)
1997

Genetic Variations for Follicular Dendritic Cell Sarcoma

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Expression for genes affiliated with Follicular Dendritic Cell Sarcoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Follicular Dendritic Cell Sarcoma

Search GEO for disease gene expression data for Follicular Dendritic Cell Sarcoma.

Pathways for genes affiliated with Follicular Dendritic Cell Sarcoma

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12EMD Millipore, 53Reactome, 29KEGG
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Compounds for genes affiliated with Follicular Dendritic Cell Sarcoma

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44Novoseek, 2BitterDB, 59Tocris Bioscience, 49PharmGKB, 28IUPHAR, 11DrugBank, 24HMDB
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Compounds related to Follicular Dendritic Cell Sarcoma according to GeneCards/GeneDecks:

(show all 33)
idCompoundScoreTop Affiliating Genes
1cycloheximide4410.5CR1
2cr2+4410.3CR2, CR1
3mycophenolate sodium4410.2CR1, IL2RA
4aristolochic acid44 211.1VIM
5okt34410.1FCER2, IL2RA, CR2
6asulam4410.0PPL, DSP
7tunicamycin44 5911.0SLC2A1, FCER2, CLU
8cytochalasin b449.9SLC2A1, FCER2, VIM
9dexamethasone44 49 28 1112.9SLC2A1, FCER2, CLU
10toxin a449.8DSG1, DSG3
11paclitaxel44 49 1111.7TP53, CLU, SNCG
12calcitriol44 59 11 2412.7CLU, IL2RA, FCER2, SLC2A1
13ivig449.6DSG3, DSG1, IL2RA
14formaldehyde44 2410.6VIM, CR1, IL2RA, FCER2
15heparin44 28 11 2412.6SLC2A1, IL2RA, CLU, CR1
16cytarabine44 49 1111.5VIM, CR1, TP53
17vincristine44 49 1111.5TP53, IL2RA, VIM
18vitamin d449.5VIM, CR1, CLU, IL2RA
19etoposide44 49 59 1112.4VIM, CLU, IL2RA, TP53
2012-o-tetradecanoylphorbol 13-acetate449.3VIM, DSP, FSCN1, FCER2
215-aza-2deoxycytidine449.3VIM, SNCG, CLU, TP53
22doxorubicin44 49 1111.3VIM, CLU, IL2RA, TP53
23prednisolone44 28 1111.2IL2RA, DSG3, CR1
24actinomycin d449.2VIM, CLU, SLC2A1, TP53
25acetylcholine44 49 28 11 2413.1VIM, DSG3, DSG1, IL2RA
26genistein44 28 59 2 11 2414.0SLC2A1, FCER2, IL2RA, VIM
27vegf448.7VIM, CLU, IL2RA, SLC2A1, TP53
28estrogen448.5VIM, CR2, SNCG, CLU, IL2RA, SLC2A1
29serine448.4DSP, DSG3, DSG1, CLU, FSCN1, FCER2
30retinoic acid44 249.2VIM, CR1, DSP, DSG1, CLU, FSCN1
31paraffin447.9TP53, VIM, CR2, CR1, CLU, IL2RA
32tyrosine447.3DSP, SNCG, CR1, CR2, DSG3, CLU
33calcium44 49 11 249.6CR2, CR1, SNCG, DSP, DSG3, DSG1

GO Terms for genes affiliated with Follicular Dendritic Cell Sarcoma

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16Gene Ontology
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Cellular components related to Follicular Dendritic Cell Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1desmosomeGO:0300578.3EVPL, DSG1, DSG3, DSP, PPL
2plasma membraneGO:0058866.5SNCG, CR1, CR2, PPL, DSP, DSG3

Biological processes related to Follicular Dendritic Cell Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cellular response to glucose starvationGO:0421499.7TP53, SLC2A1
2intermediate filament organizationGO:0451099.7VIM, DSP
3complement activation, classical pathwayGO:0069589.6CLU, CR1, CR2
4cellular component disassembly involved in execution phase of apoptosisGO:0069219.0DSG1, DSG3, DSP, VIM
5apoptotic processGO:0069158.3IL2RA, DSG1, DSG3, DSP, VIM

Molecular functions related to Follicular Dendritic Cell Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1structural constituent of cytoskeletonGO:0052009.3DSP, PPL, VIM
2protein binding, bridgingGO:0306749.2EVPL, FSCN1, DSP

Products for genes affiliated with Follicular Dendritic Cell Sarcoma

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Sources for Follicular Dendritic Cell Sarcoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet