MCID: FLL013
MIFTS: 54

Follicular Dendritic Cell Sarcoma malady

Blood diseases, Cancer diseases, Rare diseases categories
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Summaries for Follicular Dendritic Cell Sarcoma

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8Disease Ontology, 65Wikipedia, 33MalaCards
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Wikipedia:65 Follicular Dendritic Cell Sarcoma (FDCS) is an extremely rare neoplasm. While the existence of FDC... more...

MalaCards: Follicular Dendritic Cell Sarcoma, also known as dendritic cell sarcoma, follicular, is related to sarcoma and castleman's disease. An important gene associated with Follicular Dendritic Cell Sarcoma is EVPL (envoplakin), and among its related pathways are Complement Pathway and Cell adhesion Endothelial cell contacts by junctional mechanisms. The compounds cr2+ and mycophenolate sodium have been mentioned in the context of this disorder. Affiliated tissues include tonsil, lymph node and liver, and related mouse phenotypes are homeostasis/metabolism and hematopoietic system.

Disease Ontology:8 A dendritic cell sarcoma cancer that effects the follicular dendritic cells.

Aliases & Classifications for Follicular Dendritic Cell Sarcoma

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8Disease Ontology, 10DISEASES, 49Orphanet, 62UMLS, 58SNOMED-CT, 35MeSH, 40NCIt, 36MESH via Orphanet, 59SNOMED-CT via Orphanet, 63UMLS via Orphanet, 26ICD10 via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Rare diseases
Anatomical: Blood diseases


Characteristics (Orphanet epidemiological data):

49
follicular dendritic cell sarcoma:
Age of onset: Variable


Aliases & Descriptions:

follicular dendritic cell sarcoma 8 10 49
dendritic cell sarcoma, follicular 62
follicular dendritic cell tumour 8


External Ids:

Disease Ontology8 DOID:6262
MeSH35 D054740
NCIt40 C9281
MESH via Orphanet36 D054740
SNOMED-CT58 128816008
SNOMED-CT via Orphanet59 128816008
UMLS via Orphanet63 C1260325
ICD10 via Orphanet26 C96.4

Related Diseases for Follicular Dendritic Cell Sarcoma

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17GeneCards, 18GeneDecks
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Diseases related to Follicular Dendritic Cell Sarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 77)
idRelated DiseaseScoreTop Affiliating Genes
1sarcoma31.7CLU, PPL, TP53, FCER2, CR2, DSP
2castleman's disease31.2DSG3, FSCN1
3pemphigus31.1EVPL, DSG1, DSP, PPL, DSG3
4thymoma30.5PPL, DSP, EVPL
5dendritic cell sarcoma11.4
6tonsillitis10.8
7paraneoplastic pemphigus10.7
8pharyngitis10.5
9myasthenia gravis10.5
10cervicitis10.4
11hepatitis10.4
12mediastinitis10.4
13thyroiditis10.4
14interdigitating dendritic cell sarcoma10.3
15amyloidosis10.3
16cellulitis10.3
17nonepidermolytic palmoplantar keratoderma10.1EVPL
18pemphigus vegetans10.1DSG1
19bullous impetigo10.1DSG1
20subcorneal pustular dermatosis10.1DSG1
21hailey-hailey disease10.1DSP
22epidermolysis bullosa acquisita10.1DSG1
23choroid plexus papilloma10.1TP53
24keratosis10.1DSP
25pemphigus erythematosus10.1DSP, DSG3
26bullous skin disease10.1DSG3, DSG1, EVPL
27keratoderma10.1DSP, DSG1
28palmoplantar keratosis10.1DSG1, DSP
29bullous pemphigoid10.1EVPL, DSP, PPL
30burkitt's lymphoma10.1CR2, FCER2, CXCL13
31pemphigus foliaceus10.0EVPL, DSG3, DSG1, PPL
32allergic asthma10.0FCER2, CR2, IL2RA
33membranous glomerulonephritis10.0CLU, CR1
34movement disease10.0SNCG, SLC2A1
35follicular lymphoma10.0CR2, FCER2, CR1
36peripheral t-cell lymphoma10.0CXCL13, IL2RA
37bladder transitional cell carcinoma10.0TP53, SLC2A1
38hypersensitivity reaction type ii disease10.0IL2RA, DSG3, DSG1
39anaplastic large cell lymphoma10.0CLU, FSCN1, IL2RA
40skin disease10.0FCER2, DSG1, DSG3, DSP
41smooth muscle tumor10.0VIM, CR2
42esophageal cancer10.0FSCN1, DSG1, TP53
43fibrous histiocytoma10.0FSCN1, VIM
44non-hodgkin lymphoma10.0FSCN1, CR2, IL2RA, FCER2
45angiosarcoma10.0VIM, FSCN1
46reticulosarcoma10.0FSCN1, CLU
47t-cell leukemia10.0IL2RA, FCER2, SLC2A1, CR2
48sarcoidosis10.0IL2RA, CR1, FCER2
49malignant mixed mullerian tumor10.0VIM, TP53
50non-small cell lung carcinoma10.0SLC2A1, TP53, DSP

Graphical network of the top 20 diseases related to Follicular Dendritic Cell Sarcoma:



Diseases related to follicular dendritic cell sarcoma

Symptoms for Follicular Dendritic Cell Sarcoma

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Drugs & Therapeutics for Follicular Dendritic Cell Sarcoma

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42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Follicular Dendritic Cell Sarcoma

Search NIH Clinical Center for Follicular Dendritic Cell Sarcoma

Genetic Tests for Follicular Dendritic Cell Sarcoma

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Anatomical Context for Follicular Dendritic Cell Sarcoma

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33MalaCards
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MalaCards organs/tissues related to Follicular Dendritic Cell Sarcoma:

33
Tonsil, Lymph node, Liver, Spleen, T cells, Breast, Thyroid, Lung, Bone, Colon, Bone marrow, Small intestine, Pancreas, Appendix

Animal Models for Follicular Dendritic Cell Sarcoma or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Follicular Dendritic Cell Sarcoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053767.7TP53, FCER2, CLDN1, CLU, VIM, SNCG
2MP:00053977.6FCER2, DSG3, VIM, CXCL13, IL2RA, CR2
3MP:00107687.5TP53, FCER2, CLDN1, DSP, DSG3, VIM
4MP:00053876.9CR2, TP53, FCER2, CLU, DSG3, VIM
5MP:00053846.6TP53, FCER2, DSP, DSG3, VIM, FSCN1

Publications for Follicular Dendritic Cell Sarcoma

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52PubMed
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Articles related to Follicular Dendritic Cell Sarcoma:

(show top 50)    (show all 135)
idTitleAuthorsYear
1
Inflammatory pseudotumor-like follicular dendritic cell sarcoma of the spleen: a report of six cases with increased IgG4-positive plasma cells. (23714251)
2013
2
A rare case of follicular dendritic cell sarcoma involving multiple bones. (23640234)
2013
3
Follicular dendritic cell sarcoma associated with hyaline-vascular Castleman's disease. (23914648)
2013
4
Transformation of Castleman's disease into follicular dendritic cell sarcoma, presenting as an asymptomatic intra-abdominal mass. (23981949)
2013
5
Cytogenetic abnormalities in follicular dendritic cell sarcoma: report of two cases and literature review. (23422480)
2013
6
Follicular dendritic cell sarcoma of the tonsil. (23415609)
2013
7
Pathology quiz case 1. Follicular dendritic cell sarcoma (FDS). (22801898)
2012
8
Extranodal follicular dendritic cell sarcoma with rapid growth in parapharynx: a case report. (23110021)
2012
9
Computed tomography and 18F-fluoro-2-deoxyglucose positron emission tomography findings of primary pulmonary follicular dendritic cell sarcoma: case report and a literature review. (21795995)
2012
10
Follicular dendritic cell sarcoma of the tonsil. (23251062)
2012
11
Follicular Dendritic Cell Sarcoma of the Head and Neck Expressing Thyroid Transcription Factor-1: A Case Report With Clinicopathologic and Immunohistochemical Literature Review. (21836499)
2012
12
Follicular dendritic cell sarcoma: a diagnostic challenge ! (22842383)
2012
13
I^-Synuclein is a promising new marker for staining reactive follicular dendritic cells, follicular dendritic cell sarcoma, Kaposi sarcoma, and benign and malignant vascular tumors. (21959308)
2011
14
Follicular dendritic cell sarcoma of the liver: unusual presentation of a rare tumor and literature review. (21813397)
2011
15
Follicular dendritic cell sarcoma of the lung: a report of two cases highlighting its pathological features and diagnostic pitfalls. (21240069)
2011
16
Cervical follicular dendritic cell sarcoma: a case report and review of the literature. (21658332)
2011
17
Follicular dendritic cell sarcoma of the tonsil. (20499431)
2010
18
Follicular dendritic cell sarcoma of the abdomen: the imaging findings. (20191073)
2010
19
Follicular dendritic cell sarcoma of small intestine with aberrant T-cell marker expression. (19883432)
2009
20
Follicular dendritic cell sarcoma with microtubuloreticular structure and virus-like particle production in vitro. (19432677)
2009
21
Extranodal follicular dendritic cell sarcoma of the tonsil - case report of an epithelioid cell variant with osteoclastic giant cells. (18774654)
2009
22
Follicular dendritic cell sarcoma of the parotid gland recurring 6 times within 12 years. (19884836)
2009
23
Clinical and pathological features of follicular dendritic cell sarcoma of appendix: a case report. (19719956)
2009
24
SIR 2008 annual meeting film panel case: Castleman disease complicated by follicular dendritic cell sarcoma. (18656005)
2008
25
Cytogenetic abnormality 46,XX,add(21)(q11.2) in a patient with follicular dendritic cell sarcoma. (18786443)
2008
26
Intra-abdominal follicular dendritic cell sarcoma with marked pleomorphic features and aberrant expression of neuroendocrine markers: report of a case with immunohistochemical analysis. (17721283)
2007
27
Follicular dendritic cell sarcoma of the tonsil: a case report and literature review. (17500398)
2007
28
Clinicopathologic study of intraabdominal extranodal follicular dendritic cell sarcoma]. (18194598)
2007
29
Follicular dendritic cell sarcoma: a report of 14 cases and a review of the literature. (17373675)
2007
30
Interwoven dendritic processes of follicular dendritic cell sarcoma demonstrated on ultrafast papanicolaou-stained smears: a case report. (17017440)
2006
31
Follicular dendritic cell sarcoma of lymph node--a rare entity. (16696516)
2006
32
Nodal follicular dendritic cell sarcoma of the axilla presenting as cellulitis. (16403115)
2006
33
Follicular dendritic cell sarcoma mimicking giant cell carcinoma of the pancreas. (16872443)
2006
34
Primary follicular dendritic cell sarcoma of the lung. (16978210)
2006
35
Paraneoplastic pemphigus associated with follicular dendritic cell sarcoma and Castleman disease. (16029358)
2005
36
Autoantibody production from a thymoma and a follicular dendritic cell sarcoma associated with paraneoplastic pemphigus. (16120143)
2005
37
Follicular dendritic cell sarcoma: case report and review of current management principles. (16343408)
2005
38
Symptoms in cancer patients and an unusual tumor: Case 3. Follicular dendritic cell sarcoma. (16361643)
2005
39
Metastatic follicular dendritic cell sarcoma of the stomach: a case report and review of the literature. (15285580)
2004
40
Intracranial follicular dendritic cell sarcoma. Case report. (14705740)
2003
41
Follicular dendritic cell sarcoma of the neck; a case report and literature review. (12393051)
2002
42
Extranodal follicular dendritic cell sarcoma of the head and neck region: three new cases, with a review of the literature. (11796841)
2002
43
Fine needle aspiration cytology of follicular dendritic cell sarcoma. Report of a case with cytologic detection in an extranodal site. (11015984)
2000
44
Follicular dendritic cell sarcoma of the neck: report of two cases complicated by pulmonary metastases. (10931467)
2000
45
Extranodal follicular dendritic cell sarcoma of the palate. (10052377)
1999
46
Myxoid variant of follicular dendritic cell sarcoma arising in the breast. (10196389)
1999
47
Follicular dendritic cell sarcoma and interdigitating reticulum cell sarcoma: a review. (9766802)
1998
48
Follicular dendritic cell sarcoma. Clinicopathologic analysis of 17 cases suggesting a malignant potential higher than currently recognized. (9010103)
1997
49
Follicular dendritic cell sarcoma mimicking diffuse large cell lymphoma: a case report. (9256295)
1997
50
Follicular dendritic cell sarcoma complicated by hyaline-vascular type Castleman's disease in a schizophrenic patient. (9361105)
1997

Variations for Follicular Dendritic Cell Sarcoma

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Expression for genes affiliated with Follicular Dendritic Cell Sarcoma

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Follicular Dendritic Cell Sarcoma

Search GEO for disease gene expression data for Follicular Dendritic Cell Sarcoma.

Pathways for genes affiliated with Follicular Dendritic Cell Sarcoma

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50PathCards, 53QIAGEN, 60Thomson Reuters, 55Reactome, 57SinoBiological, 30KEGG, 38NCBI BioSystems Database
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Pathways related to Follicular Dendritic Cell Sarcoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Immune response Alternative complement pathway60
Immune response Lectin Induced complement pathway60
Immune response Classic complement pathway60
9.6CR1, CLU, CR2
29.6CLDN1, VIM, DSP
39.4CR1, IL2RA, FCER2, CR2
4
Show member pathways
9.3FCER2, IL2RA, CR2, TP53
59.2TP53, FCER2, VIM, CR2
6
Show member pathways
9.0DSP, DSG1, DSG3, VIM
79.0DSP, EVPL, VIM, PPL
8
Show member pathways
Proteasome Degradation38
Immune response Antigen presentation by MHC class I60
8.6TP53, DSP, DSG1, DSG3, VIM
9
Show member pathways
8.3IL2RA, CXCL13, VIM, DSP, TP53

Compounds for genes affiliated with Follicular Dendritic Cell Sarcoma

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Sources:
45Novoseek, 61Tocris Bioscience, 3BitterDB, 11DrugBank, 24HMDB, 51PharmGKB, 29IUPHAR
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Compounds related to Follicular Dendritic Cell Sarcoma according to GeneCards/GeneDecks:

(show all 50)
idCompoundScoreTop Affiliating Genes
1cr2+4510.3CR2, CR1
2mycophenolate sodium4510.2CR1, IL2RA
3okt34510.1FCER2, IL2RA, CR2
4tunicamycin45 6111.1SLC2A1, CLU, FCER2
5toxin a4510.0DSG3, DSG1
6asulam4510.0DSP, PPL
7cytochalasin b4510.0FCER2, VIM, SLC2A1
8aristolochic acid45 311.0TP53, VIM
9mannose459.8FCER2, CR1, SLC2A1
10temozolomide45 1110.8TP53, VIM
11calcitriol45 61 24 1112.8SLC2A1, IL2RA, CLU, FCER2
12ivig459.8IL2RA, DSG3, DSG1
13folate459.7IL2RA, VIM, CLU
14fmlp459.7FCER2, VIM, CR1
15vincristine45 51 1111.7IL2RA, VIM, TP53
16cytarabine45 51 1111.7CR1, VIM, TP53
17lactate459.6SLC2A1, VIM, CLU, FCER2
18formaldehyde45 2410.6CR1, IL2RA, VIM, FCER2
19prednisolone45 29 1111.6DSG3, IL2RA, CR1
20genistein45 29 61 3 24 1114.6FCER2, VIM, IL2RA, SLC2A1
21dmso459.6CR1, VIM, DSP
22thymidine45 2410.6TP53, FCER2, CLU, IL2RA
23vitamin d459.6CLU, VIM, IL2RA, CR1
24butyrate459.5TP53, CLU, VIM, SLC2A1
25etoposide45 51 61 1112.5TP53, CLU, VIM, IL2RA
26actinomycin d459.5TP53, CLU, VIM, SLC2A1
27cisplatin45 51 61 1112.5SLC2A1, IL2RA, CLU, TP53
28doxorubicin45 51 1111.5TP53, CLU, VIM, IL2RA
2912-o-tetradecanoylphorbol 13-acetate459.5FSCN1, VIM, DSP, FCER2
30gnrh459.4CLU, VIM, IL2RA
315-aza-2deoxycytidine459.4TP53, CLU, VIM, SNCG
32dexamethasone45 51 29 1112.4SLC2A1, IL2RA, VIM, CLU, FCER2
33acetylcholine45 51 29 24 1113.4DSG1, DSG3, VIM, IL2RA
34agar459.3SLC2A1, SNCG, VIM
35adenylate459.3SLC2A1, CR1, IL2RA, VIM
36heparin45 29 24 1112.3CLU, VIM, IL2RA, CR1, SLC2A1
37atp45 2910.3FCER2, CLU, VIM, CR1, SLC2A1
38cysteine459.3SLC2A1, IL2RA, VIM, CLU, FCER2
39progesterone45 29 61 24 1113.2TP53, CLU, DSP, VIM
40vegf459.2TP53, CLU, VIM, IL2RA, SLC2A1
415fluorouracil459.1SLC2A1, IL2RA, TP53
42h2o2459.1IL2RA, VIM, CLU, TP53
43paclitaxel45 51 1111.1TP53, CLU, VIM, IL2RA, SNCG
44cycloheximide458.8TP53, FCER2, CLU, VIM, CR1, CR2
45estrogen458.6TP53, CLU, VIM, IL2RA, SNCG, CR2
46retinoic acid45 249.2TP53, FCER2, CLU, DSP, DSG1, VIM
47paraffin457.9SLC2A1, TP53, FCER2, CLU, VIM, FSCN1
48serine457.5TP53, FCER2, CLU, DSP, DSG1, DSG3
49tyrosine457.5DSG3, DSP, CLU, FCER2, FSCN1, IL2RA
50calcium45 51 24 119.8DSP, CLU, CLDN1, FCER2, DSG1, DSG3

GO Terms for genes affiliated with Follicular Dendritic Cell Sarcoma

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16Gene Ontology
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Cellular components related to Follicular Dendritic Cell Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.7CR2, IL2RA, FCER2
2cornified envelopeGO:0015339.7DSP, EVPL
3desmosomeGO:0300578.6PPL, DSP, DSG1, DSG3, EVPL
4plasma membraneGO:0058866.4VIM, SNCG, IL2RA, CR2, DSG3, DSG1
5extracellular vesicular exosomeGO:0700626.2PPL, SLC2A1, EVPL, CR2, CR1, SNCG

Biological processes related to Follicular Dendritic Cell Sarcoma according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1intermediate filament organizationGO:0451099.9VIM, DSP
2peptide cross-linkingGO:0181499.9EVPL, DSP
3positive regulation of intrinsic apoptotic signaling pathwayGO:20012449.8CLU, TP53
4complement activation, classical pathwayGO:0069589.8CLU, CR2, CR1
5cellular response to glucose starvationGO:0421499.8SLC2A1, TP53
6Notch signaling pathwayGO:0072199.6TP53, FCER2, IL2RA
7release of cytochrome c from mitochondriaGO:0018369.5CLU, TP53
8cellular component disassembly involved in execution phase of apoptosisGO:0069219.2DSP, DSG1, DSG3, VIM
9apoptotic processGO:0069158.5TP53, DSP, DSG1, DSG3, VIM, IL2RA

Molecular functions related to Follicular Dendritic Cell Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1structural molecule activityGO:0051989.7EVPL, DSP, CLDN1
2structural constituent of cytoskeletonGO:0052009.6DSP, PPL
3protein binding, bridgingGO:0306749.5EVPL, FSCN1, DSP
4scaffold protein bindingGO:0971109.5VIM, DSP
5identical protein bindingGO:0428029.1TP53, CLDN1, VIM, SLC2A1

Products for genes affiliated with Follicular Dendritic Cell Sarcoma

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  • Antibodies
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Sources for Follicular Dendritic Cell Sarcoma

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet