MCID: FLL013
MIFTS: 47

Follicular Dendritic Cell Sarcoma malady

Blood diseases, Cancer diseases, Rare diseases categories

Aliases & Classifications for Follicular Dendritic Cell Sarcoma

About this section
Sources:
9Disease Ontology, 11DISEASES, 47Orphanet, 60UMLS, 33MeSH, 38NCIt, 55SNOMED-CT, 34MESH via Orphanet, 26ICD10 via Orphanet, 61UMLS via Orphanet
See all sources

Follicular Dendritic Cell Sarcoma, Aliases & Descriptions:

Name: Follicular Dendritic Cell Sarcoma 9 11 47
Dendritic Cell Sarcoma, Follicular 60
 
Follicular Dendritic Cell Tumour 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Rare diseases
Anatomical: Blood diseases


Characteristics (Orphanet epidemiological data):

47
follicular dendritic cell sarcoma:
Age of onset: All ages


External Ids:

Disease Ontology9 DOID:6262
MeSH33 D054740
NCIt38 C9281
Orphanet47 86902
SNOMED-CT55 128816008
MESH via Orphanet34 D054740
ICD10 via Orphanet26 C96.4
UMLS via Orphanet61 C1260325

Summaries for Follicular Dendritic Cell Sarcoma

About this section


Wikipedia:63 Follicular Dendritic Cell Sarcoma (FDCS) is an extremely rare neoplasm. While the existence of FDC... more...

MalaCards based summary: Follicular Dendritic Cell Sarcoma, also known as dendritic cell sarcoma, follicular, is related to pemphigus and thymoma. An important gene associated with Follicular Dendritic Cell Sarcoma is EVPL (envoplakin), and among its related pathways are Complement Pathway and Cell adhesion Endothelial cell contacts by junctional mechanisms. The compounds cr2+ and mycophenolate sodium have been mentioned in the context of this disorder. Affiliated tissues include tonsil, lymph node and liver, and related mouse phenotypes are homeostasis/metabolism and hematopoietic system.

Disease Ontology:9 A dendritic cell sarcoma cancer that effects the follicular dendritic cells.

Related Diseases for Follicular Dendritic Cell Sarcoma

About this section

Diseases related to Follicular Dendritic Cell Sarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 79)
idRelated DiseaseScoreTop Affiliating Genes
1pemphigus31.3EVPL, DSG1, DSP, PPL, DSG3
2thymoma30.8PPL, DSP, EVPL
3sarcoma30.7CLU, PPL, TP53, FCER2, CR2, DSP
4dendritic cell sarcoma11.4
5tonsillitis10.8
6paraneoplastic pemphigus10.8
7castleman's disease10.8
8mediastinitis10.6
9palmoplantar keratoderma, nonepidermolytic10.6EVPL
10myasthenia gravis10.5
11thyroiditis10.5
12pemphigus vegetans10.5DSG1
13hypersensitivity syndrome, carbamazepine-induced10.5DSG1
14subcorneal pustular dermatosis10.5DSG1
15hailey-hailey disease10.5DSP
16epidermolysis bullosa acquisita10.5DSG1
17hepatitis10.5
18pharyngitis10.5
19cervicitis10.5
20choroid plexus papilloma10.4TP53
21keratosis10.4DSP
22multicentric castleman’s disease10.4DSG3, FSCN1
23pemphigus erythematosus10.4DSP, DSG3
24bullous skin disease10.3DSG3, DSG1, EVPL
25kaposi sarcoma10.3
26interdigitating dendritic cell sarcoma10.3
27amyloidosis10.3
28cellulitis10.3
29peritonitis10.3
30secondary amyloidosis10.3
31keratoderma10.3DSP, DSG1
32palmoplantar keratosis10.3DSG1, DSP
33bullous pemphigoid10.3EVPL, DSP, PPL
34burkitt lymphoma10.3CR2, FCER2, CXCL13
35pemphigus foliaceus10.2EVPL, DSG3, DSG1, PPL
36allergic asthma10.2FCER2, CR2, IL2RA
37membranous glomerulonephritis, antenatal10.2CLU, CR1
38movement disease10.2SNCG, SLC2A1
39follicular lymphoma10.2CR2, FCER2, CR1
40peripheral t-cell lymphoma10.2CXCL13, IL2RA
41bladder transitional cell carcinoma10.2TP53, SLC2A1
42hypersensitivity reaction type ii disease10.1IL2RA, DSG3, DSG1
43anaplastic large cell lymphoma10.1CLU, FSCN1, IL2RA
44skin disease10.1FCER2, DSG1, DSG3, DSP
45smooth muscle tumor10.1VIM, CR2
46esophageal cancer10.1FSCN1, DSG1, TP53
47fibrous histiocytoma10.1FSCN1, VIM
48lymphoma, non-hodgkin10.1FSCN1, CR2, IL2RA, FCER2
49angiosarcoma10.0VIM, FSCN1
50reticulosarcoma10.0FSCN1, CLU

Graphical network of the top 20 diseases related to Follicular Dendritic Cell Sarcoma:



Diseases related to follicular dendritic cell sarcoma

Symptoms for Follicular Dendritic Cell Sarcoma

About this section

Drugs & Therapeutics for Follicular Dendritic Cell Sarcoma

About this section

Drug clinical trials:

Search ClinicalTrials for Follicular Dendritic Cell Sarcoma

Search NIH Clinical Center for Follicular Dendritic Cell Sarcoma

Genetic Tests for Follicular Dendritic Cell Sarcoma

About this section

Anatomical Context for Follicular Dendritic Cell Sarcoma

About this section

MalaCards organs/tissues related to Follicular Dendritic Cell Sarcoma:

31
Tonsil, Lymph node, Liver, Bone, Spleen, Thyroid, T cells, Bone marrow, Brain, Colon, Lung, Breast, Small intestine, Pancreas, Testis, Appendix

Animal Models for Follicular Dendritic Cell Sarcoma or affiliated genes

About this section

MGI Mouse Phenotypes related to Follicular Dendritic Cell Sarcoma:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053767.7TP53, FCER2, CLDN1, CLU, VIM, SNCG
2MP:00053977.6FCER2, DSG3, VIM, CXCL13, IL2RA, CR2
3MP:00107687.5TP53, FCER2, CLDN1, DSP, DSG3, VIM
4MP:00053876.9CR2, TP53, FCER2, CLU, DSG3, VIM
5MP:00053846.6TP53, FCER2, DSP, DSG3, VIM, FSCN1

Publications for Follicular Dendritic Cell Sarcoma

About this section

Articles related to Follicular Dendritic Cell Sarcoma:

(show top 50)    (show all 159)
idTitleAuthorsYear
1
Follicular dendritic cell sarcoma of the tonsil. (25512260)
2015
2
Follicular dendritic cell sarcoma of the right tonsil: A case report and literature review. (25621026)
2015
3
Intraperitoneal follicular dendritic cell sarcoma: role of chemotherapy and bone marrow allotransplantation in locally advanced disease? (25698886)
2015
4
Paraneoplastic pemphigus associated with primary pulmonar follicular dendritic cell sarcoma showing good response to treatment. (25388966)
2014
5
Extranodal follicular dendritic cell sarcoma of the soft palate: a case report. (25674273)
2014
6
Response of follicular dendritic cell sarcoma to gemcitabine and docetaxel: report of two cases and literature review. (25009738)
2014
7
Follicular Dendritic Cell Sarcoma Presenting As a Thyroid Mass. (24663046)
2014
8
A 46-year-old Chinese woman presenting with retroperitoneal follicular dendritic cell sarcoma: a case report. (24708915)
2014
9
Recalcitrant paraneoplastic pemphigus associated with follicular dendritic cell sarcoma: response to prolonged rituximab and ciclosporin therapy. (25367731)
2014
10
Mediastinal follicular dendritic cell sarcoma with paraneoplastic pemphigus. (25406405)
2014
11
Inflammatory pseudotumor-like follicular dendritic cell sarcoma of the spleen: a report of six cases with increased IgG4-positive plasma cells. (23714251)
2013
12
A rare case of follicular dendritic cell sarcoma involving multiple bones. (23640234)
2013
13
Follicular dendritic cell sarcoma associated with hyaline-vascular Castleman's disease. (23914648)
2013
14
Transformation of Castleman's disease into follicular dendritic cell sarcoma, presenting as an asymptomatic intra-abdominal mass. (23981949)
2013
15
Cytogenetic abnormalities in follicular dendritic cell sarcoma: report of two cases and literature review. (23422480)
2013
16
Pathology quiz case 1. Follicular dendritic cell sarcoma (FDS). (22801898)
2012
17
Extranodal follicular dendritic cell sarcoma with rapid growth in parapharynx: a case report. (23110021)
2012
18
Computed tomography and 18F-fluoro-2-deoxyglucose positron emission tomography findings of primary pulmonary follicular dendritic cell sarcoma: case report and a literature review. (21795995)
2012
19
Follicular dendritic cell sarcoma of the tonsil. (23251062)
2012
20
Follicular Dendritic Cell Sarcoma of the Head and Neck Expressing Thyroid Transcription Factor-1: A Case Report With Clinicopathologic and Immunohistochemical Literature Review. (21836499)
2012
21
I^-Synuclein is a promising new marker for staining reactive follicular dendritic cells, follicular dendritic cell sarcoma, Kaposi sarcoma, and benign and malignant vascular tumors. (21959308)
2011
22
Follicular dendritic cell sarcoma of the liver: unusual presentation of a rare tumor and literature review. (21813397)
2011
23
Follicular dendritic cell sarcoma of the lung: a report of two cases highlighting its pathological features and diagnostic pitfalls. (21240069)
2011
24
Follicular dendritic cell sarcoma of the tonsil. (20499431)
2010
25
Follicular dendritic cell sarcoma of the abdomen: the imaging findings. (20191073)
2010
26
Follicular dendritic cell sarcoma of small intestine with aberrant T-cell marker expression. (19883432)
2009
27
Follicular dendritic cell sarcoma with microtubuloreticular structure and virus-like particle production in vitro. (19432677)
2009
28
Extranodal follicular dendritic cell sarcoma of the tonsil - case report of an epithelioid cell variant with osteoclastic giant cells. (18774654)
2009
29
SIR 2008 annual meeting film panel case: Castleman disease complicated by follicular dendritic cell sarcoma. (18656005)
2008
30
Cytogenetic abnormality 46,XX,add(21)(q11.2) in a patient with follicular dendritic cell sarcoma. (18786443)
2008
31
Intra-abdominal follicular dendritic cell sarcoma with marked pleomorphic features and aberrant expression of neuroendocrine markers: report of a case with immunohistochemical analysis. (17721283)
2007
32
Follicular dendritic cell sarcoma of the tonsil: a case report and literature review. (17500398)
2007
33
Clinicopathologic study of intraabdominal extranodal follicular dendritic cell sarcoma]. (18194598)
2007
34
Follicular dendritic cell sarcoma: a report of 14 cases and a review of the literature. (17373675)
2007
35
Interwoven dendritic processes of follicular dendritic cell sarcoma demonstrated on ultrafast papanicolaou-stained smears: a case report. (17017440)
2006
36
Follicular dendritic cell sarcoma of lymph node--a rare entity. (16696516)
2006
37
Nodal follicular dendritic cell sarcoma of the axilla presenting as cellulitis. (16403115)
2006
38
Follicular dendritic cell sarcoma mimicking giant cell carcinoma of the pancreas. (16872443)
2006
39
Paraneoplastic pemphigus associated with follicular dendritic cell sarcoma and Castleman disease. (16029358)
2005
40
Autoantibody production from a thymoma and a follicular dendritic cell sarcoma associated with paraneoplastic pemphigus. (16120143)
2005
41
Follicular dendritic cell sarcoma: case report and review of current management principles. (16343408)
2005
42
Symptoms in cancer patients and an unusual tumor: Case 3. Follicular dendritic cell sarcoma. (16361643)
2005
43
Metastatic follicular dendritic cell sarcoma of the stomach: a case report and review of the literature. (15285580)
2004
44
Intracranial follicular dendritic cell sarcoma. Case report. (14705740)
2003
45
Follicular dendritic cell sarcoma of the neck; a case report and literature review. (12393051)
2002
46
Fine needle aspiration cytology of follicular dendritic cell sarcoma. Report of a case with cytologic detection in an extranodal site. (11015984)
2000
47
Extranodal follicular dendritic cell sarcoma of the palate. (10052377)
1999
48
Myxoid variant of follicular dendritic cell sarcoma arising in the breast. (10196389)
1999
49
Follicular dendritic cell sarcoma. Clinicopathologic analysis of 17 cases suggesting a malignant potential higher than currently recognized. (9010103)
1997
50
Follicular dendritic cell sarcoma mimicking diffuse large cell lymphoma: a case report. (9256295)
1997

Variations for Follicular Dendritic Cell Sarcoma

About this section

Expression for genes affiliated with Follicular Dendritic Cell Sarcoma

About this section
Search GEO for disease gene expression data for Follicular Dendritic Cell Sarcoma.

Pathways for genes affiliated with Follicular Dendritic Cell Sarcoma

About this section

Pathways related to Follicular Dendritic Cell Sarcoma according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Immune response Alternative complement pathway58
Immune response Lectin Induced complement pathway58
Immune response Classic complement pathway58
9.6CLU, CR1, CR2
29.6VIM, DSP, CLDN1
39.4FCER2, IL2RA, CR1, CR2
4
Show member pathways
9.3CR2, IL2RA, FCER2, TP53
59.2TP53, FCER2, VIM, CR2
6
Show member pathways
9.0DSP, DSG1, DSG3, VIM
79.0EVPL, VIM, DSP, PPL
8
Show member pathways
Proteasome Degradation36
Immune response Antigen presentation by MHC class I58
8.6VIM, DSG3, DSG1, DSP, TP53
9
Show member pathways
8.3DSP, VIM, CXCL13, IL2RA, TP53

Compounds for genes affiliated with Follicular Dendritic Cell Sarcoma

About this section

Compounds related to Follicular Dendritic Cell Sarcoma according to GeneCards Suite gene sharing:

(show all 50)
idCompoundScoreTop Affiliating Genes
1cr2+4310.3CR2, CR1
2mycophenolate sodium4310.2CR1, IL2RA
3okt34310.1FCER2, IL2RA, CR2
4tunicamycin43 5911.1SLC2A1, CLU, FCER2
5toxin a4310.0DSG3, DSG1
6asulam4310.0DSP, PPL
7cytochalasin b4310.0FCER2, VIM, SLC2A1
8aristolochic acid43 211.0TP53, VIM
9mannose439.8FCER2, CR1, SLC2A1
10temozolomide43 1210.8TP53, VIM
11calcitriol43 59 24 1212.8SLC2A1, IL2RA, CLU, FCER2
12ivig439.8IL2RA, DSG3, DSG1
13folate439.7IL2RA, VIM, CLU
14fmlp439.7FCER2, VIM, CR1
15vincristine43 49 1211.7IL2RA, VIM, TP53
16cytarabine43 49 1211.7CR1, VIM, TP53
17lactate439.6SLC2A1, VIM, CLU, FCER2
18formaldehyde43 2410.6CR1, IL2RA, VIM, FCER2
19prednisolone43 28 1211.6DSG3, IL2RA, CR1
20genistein43 28 59 2 24 1214.6FCER2, VIM, IL2RA, SLC2A1
21dmso439.6CR1, VIM, DSP
22thymidine43 2410.6TP53, FCER2, CLU, IL2RA
23vitamin d439.6CLU, VIM, IL2RA, CR1
24butyrate439.5TP53, CLU, VIM, SLC2A1
25etoposide43 49 59 1212.5TP53, CLU, VIM, IL2RA
26actinomycin d439.5TP53, CLU, VIM, SLC2A1
27cisplatin43 49 59 1212.5SLC2A1, IL2RA, CLU, TP53
28doxorubicin43 49 1211.5TP53, CLU, VIM, IL2RA
2912-o-tetradecanoylphorbol 13-acetate439.5FSCN1, VIM, DSP, FCER2
30gnrh439.4CLU, VIM, IL2RA
315-aza-2deoxycytidine439.4TP53, CLU, VIM, SNCG
32dexamethasone43 49 28 1212.4SLC2A1, IL2RA, VIM, CLU, FCER2
33acetylcholine43 49 28 24 1213.4DSG1, DSG3, VIM, IL2RA
34agar439.3SLC2A1, SNCG, VIM
35adenylate439.3SLC2A1, CR1, IL2RA, VIM
36heparin43 28 24 1212.3CLU, VIM, IL2RA, CR1, SLC2A1
37atp43 2810.3FCER2, CLU, VIM, CR1, SLC2A1
38cysteine439.3SLC2A1, IL2RA, VIM, CLU, FCER2
39progesterone43 28 59 24 1213.2TP53, CLU, DSP, VIM
40vegf439.2TP53, CLU, VIM, IL2RA, SLC2A1
415fluorouracil439.1SLC2A1, IL2RA, TP53
42h2o2439.1IL2RA, VIM, CLU, TP53
43paclitaxel43 49 1211.1TP53, CLU, VIM, IL2RA, SNCG
44cycloheximide438.8TP53, FCER2, CLU, VIM, CR1, CR2
45estrogen438.6TP53, CLU, VIM, IL2RA, SNCG, CR2
46retinoic acid43 249.2TP53, FCER2, CLU, DSP, DSG1, VIM
47paraffin437.9SLC2A1, TP53, FCER2, CLU, VIM, FSCN1
48serine437.5TP53, FCER2, CLU, DSP, DSG1, DSG3
49tyrosine437.5DSG3, DSP, CLU, FCER2, FSCN1, IL2RA
50calcium43 49 24 129.8DSP, CLU, CLDN1, FCER2, DSG1, DSG3

GO Terms for genes affiliated with Follicular Dendritic Cell Sarcoma

About this section

Cellular components related to Follicular Dendritic Cell Sarcoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098979.7CR2, IL2RA, FCER2
2cornified envelopeGO:00015339.7DSP, EVPL
3desmosomeGO:00300578.6PPL, DSP, DSG1, DSG3, EVPL
4plasma membraneGO:00058866.4PPL, FCER2, DSP, DSG1, DSG3, VIM
5extracellular vesicular exosomeGO:00700626.2SLC2A1, PPL, FCER2, CLU, DSP, DSG3

Biological processes related to Follicular Dendritic Cell Sarcoma according to GeneCards Suite gene sharing:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1intermediate filament organizationGO:00451099.9DSP, VIM
2peptide cross-linkingGO:00181499.9DSP, EVPL
3positive regulation of intrinsic apoptotic signaling pathwayGO:020012449.8CLU, TP53
4complement activation, classical pathwayGO:00069589.8CR2, CR1, CLU
5cellular response to glucose starvationGO:00421499.8SLC2A1, TP53
6Notch signaling pathwayGO:00072199.6IL2RA, FCER2, TP53
7release of cytochrome c from mitochondriaGO:00018369.5CLU, TP53
8cellular component disassembly involved in execution phase of apoptosisGO:00069219.2VIM, DSG3, DSG1, DSP
9apoptotic processGO:00069158.5TP53, DSP, DSG1, DSG3, VIM, IL2RA

Molecular functions related to Follicular Dendritic Cell Sarcoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1structural molecule activityGO:00051989.7EVPL, DSP, CLDN1
2structural constituent of cytoskeletonGO:00052009.6DSP, PPL
3protein binding, bridgingGO:00306749.5EVPL, FSCN1, DSP
4scaffold protein bindingGO:00971109.5VIM, DSP
5identical protein bindingGO:00428029.1TP53, CLDN1, VIM, SLC2A1

Products for genes affiliated with Follicular Dendritic Cell Sarcoma

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Follicular Dendritic Cell Sarcoma

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet