MCID: FLL013
MIFTS: 54

Follicular Dendritic Cell Sarcoma malady

Blood diseases, Cancer diseases, Rare diseases categories
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Summaries for Follicular Dendritic Cell Sarcoma

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Wikipedia:65 Follicular Dendritic Cell Sarcoma (FDCS) is an extremely rare neoplasm. While the existence of FDC... more...

MalaCards based summary: Follicular Dendritic Cell Sarcoma, also known as dendritic cell sarcoma, follicular, is related to castleman's disease and pemphigus. An important gene associated with Follicular Dendritic Cell Sarcoma is EVPL (envoplakin), and among its related pathways are Complement Pathway and Cell adhesion Endothelial cell contacts by junctional mechanisms. The compounds cr2+ and mycophenolate sodium have been mentioned in the context of this disorder. Affiliated tissues include tonsil, lymph node and liver, and related mouse phenotypes are homeostasis/metabolism and hematopoietic system.

Disease Ontology:8 A dendritic cell sarcoma cancer that effects the follicular dendritic cells.

Aliases & Classifications for Follicular Dendritic Cell Sarcoma

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Sources:
8Disease Ontology, 10DISEASES, 48Orphanet, 62UMLS, 57SNOMED-CT, 34MeSH, 39NCIt, 35MESH via Orphanet, 26ICD10 via Orphanet, 63UMLS via Orphanet
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Follicular Dendritic Cell Sarcoma, Aliases & Descriptions:

Name: Follicular Dendritic Cell Sarcoma 8 10 48
Dendritic Cell Sarcoma, Follicular 62
 
Follicular Dendritic Cell Tumour 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Rare diseases
Anatomical: Blood diseases


Characteristics (Orphanet epidemiological data):

48
follicular dendritic cell sarcoma:
Age of onset: Variable


External Ids:

Disease Ontology8 DOID:6262
MeSH34 D054740
NCIt39 C9281
SNOMED-CT57 128816008
MESH via Orphanet35 D054740
ICD10 via Orphanet26 C96.4
UMLS via Orphanet63 C1260325

Related Diseases for Follicular Dendritic Cell Sarcoma

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Diseases related to Follicular Dendritic Cell Sarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 77)
idRelated DiseaseScoreTop Affiliating Genes
1castleman's disease31.7DSG3, FSCN1
2pemphigus31.3PPL, DSP, DSG1, DSG3, EVPL
3thymoma30.8PPL, DSP, EVPL
4sarcoma30.7PPL, TP53, FCER2, CLU, DSP, DSG1
5dendritic cell sarcoma11.4
6paraneoplastic pemphigus10.8
7tonsillitis10.8
8mediastinitis10.6
9nonepidermolytic palmoplantar keratoderma10.6EVPL
10myasthenia gravis10.5
11pharyngitis10.5
12thyroiditis10.5
13pemphigus vegetans10.5DSG1
14bullous impetigo10.5DSG1
15subcorneal pustular dermatosis10.5DSG1
16hailey-hailey disease10.5DSP
17epidermolysis bullosa acquisita10.5DSG1
18hepatitis10.4
19cervicitis10.4
20choroid plexus papilloma10.4TP53
21keratosis10.4DSP
22pemphigus erythematosus10.4DSP, DSG3
23bullous skin disease10.3DSG1, DSG3, EVPL
24keratoderma10.3DSP, DSG1
25interdigitating dendritic cell sarcoma10.3
26amyloidosis10.3
27cellulitis10.3
28peritonitis10.3
29palmoplantar keratosis10.3DSG1, DSP
30bullous pemphigoid10.3EVPL, DSP, PPL
31burkitt's lymphoma10.3CR2, CXCL13, FCER2
32pemphigus foliaceus10.2PPL, DSG1, DSG3, EVPL
33allergic asthma10.2CR2, IL2RA, FCER2
34membranous glomerulonephritis10.2CLU, CR1
35movement disease10.2SNCG, SLC2A1
36follicular lymphoma10.2CR2, CR1, FCER2
37peripheral t-cell lymphoma10.2CXCL13, IL2RA
38bladder transitional cell carcinoma10.2SLC2A1, TP53
39hypersensitivity reaction type ii disease10.2IL2RA, DSG3, DSG1
40anaplastic large cell lymphoma10.1IL2RA, FSCN1, CLU
41skin disease10.1DSG3, DSG1, DSP, FCER2
42smooth muscle tumor10.1VIM, CR2
43esophageal cancer10.1FSCN1, DSG1, TP53
44fibrous histiocytoma10.1FSCN1, VIM
45non-hodgkin lymphoma10.1CR2, IL2RA, FSCN1, FCER2
46angiosarcoma10.0VIM, FSCN1
47reticulosarcoma10.0FSCN1, CLU
48t-cell leukemia10.0FCER2, IL2RA, CR2, SLC2A1
49sarcoidosis10.0CR1, IL2RA, FCER2
50malignant mixed mullerian tumor10.0VIM, TP53

Graphical network of the top 20 diseases related to Follicular Dendritic Cell Sarcoma:



Diseases related to follicular dendritic cell sarcoma

Symptoms for Follicular Dendritic Cell Sarcoma

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Drugs & Therapeutics for Follicular Dendritic Cell Sarcoma

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Drug clinical trials:

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Search NIH Clinical Center for Follicular Dendritic Cell Sarcoma

Genetic Tests for Follicular Dendritic Cell Sarcoma

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Anatomical Context for Follicular Dendritic Cell Sarcoma

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MalaCards organs/tissues related to Follicular Dendritic Cell Sarcoma:

32
Tonsil, Lymph node, Liver, Spleen, Thyroid, T cells, Bone, Colon, Lung, Breast, Bone marrow, Small intestine, Pancreas, Appendix

Animal Models for Follicular Dendritic Cell Sarcoma or affiliated genes

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MGI Mouse Phenotypes related to Follicular Dendritic Cell Sarcoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053767.7CR2, VIM, SNCG, SLC2A1, CLU, CLDN1
2MP:00053977.6FCER2, DSG3, VIM, CXCL13, IL2RA, CR2
3MP:00107687.5DSP, CLDN1, CR2, IL2RA, VIM, DSG3
4MP:00053876.9VIM, CXCL13, FSCN1, IL2RA, CR2, DSG3
5MP:00053846.6DSP, SNCG, TP53, DSG3, VIM, FSCN1

Publications for Follicular Dendritic Cell Sarcoma

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Articles related to Follicular Dendritic Cell Sarcoma:

(show top 50)    (show all 149)
idTitleAuthorsYear
1
Paraneoplastic pemphigus associated with primary pulmonar follicular dendritic cell sarcoma showing good response to treatment. (25388966)
2014
2
Response of follicular dendritic cell sarcoma to gemcitabine and docetaxel: report of two cases and literature review. (25009738)
2014
3
Follicular Dendritic Cell Sarcoma Presenting As a Thyroid Mass. (24663046)
2014
4
A 46-year-old Chinese woman presenting with retroperitoneal follicular dendritic cell sarcoma: a case report. (24708915)
2014
5
Recalcitrant paraneoplastic pemphigus associated with follicular dendritic cell sarcoma: response to prolonged rituximab and ciclosporin therapy. (25367731)
2014
6
Mediastinal follicular dendritic cell sarcoma with paraneoplastic pemphigus. (25406405)
2014
7
Inflammatory pseudotumor-like follicular dendritic cell sarcoma of the spleen: a report of six cases with increased IgG4-positive plasma cells. (23714251)
2013
8
A rare case of follicular dendritic cell sarcoma involving multiple bones. (23640234)
2013
9
Follicular dendritic cell sarcoma associated with hyaline-vascular Castleman's disease. (23914648)
2013
10
Transformation of Castleman's disease into follicular dendritic cell sarcoma, presenting as an asymptomatic intra-abdominal mass. (23981949)
2013
11
Cytogenetic abnormalities in follicular dendritic cell sarcoma: report of two cases and literature review. (23422480)
2013
12
Pathology quiz case 1. Follicular dendritic cell sarcoma (FDS). (22801898)
2012
13
Extranodal follicular dendritic cell sarcoma with rapid growth in parapharynx: a case report. (23110021)
2012
14
Computed tomography and 18F-fluoro-2-deoxyglucose positron emission tomography findings of primary pulmonary follicular dendritic cell sarcoma: case report and a literature review. (21795995)
2012
15
Follicular dendritic cell sarcoma of the tonsil. (23251062)
2012
16
Follicular Dendritic Cell Sarcoma of the Head and Neck Expressing Thyroid Transcription Factor-1: A Case Report With Clinicopathologic and Immunohistochemical Literature Review. (21836499)
2012
17
I^-Synuclein is a promising new marker for staining reactive follicular dendritic cells, follicular dendritic cell sarcoma, Kaposi sarcoma, and benign and malignant vascular tumors. (21959308)
2011
18
Follicular dendritic cell sarcoma of the liver: unusual presentation of a rare tumor and literature review. (21813397)
2011
19
Follicular dendritic cell sarcoma of the lung: a report of two cases highlighting its pathological features and diagnostic pitfalls. (21240069)
2011
20
Follicular dendritic cell sarcoma of the tonsil. (20499431)
2010
21
Follicular dendritic cell sarcoma of the abdomen: the imaging findings. (20191073)
2010
22
Follicular dendritic cell sarcoma of small intestine with aberrant T-cell marker expression. (19883432)
2009
23
Follicular dendritic cell sarcoma with microtubuloreticular structure and virus-like particle production in vitro. (19432677)
2009
24
Extranodal follicular dendritic cell sarcoma of the tonsil - case report of an epithelioid cell variant with osteoclastic giant cells. (18774654)
2009
25
Follicular dendritic cell sarcoma of the parotid gland recurring 6 times within 12 years. (19884836)
2009
26
SIR 2008 annual meeting film panel case: Castleman disease complicated by follicular dendritic cell sarcoma. (18656005)
2008
27
Cytogenetic abnormality 46,XX,add(21)(q11.2) in a patient with follicular dendritic cell sarcoma. (18786443)
2008
28
Intra-abdominal follicular dendritic cell sarcoma with marked pleomorphic features and aberrant expression of neuroendocrine markers: report of a case with immunohistochemical analysis. (17721283)
2007
29
Follicular dendritic cell sarcoma of the tonsil: a case report and literature review. (17500398)
2007
30
Clinicopathologic study of intraabdominal extranodal follicular dendritic cell sarcoma]. (18194598)
2007
31
Follicular dendritic cell sarcoma: a report of 14 cases and a review of the literature. (17373675)
2007
32
Interwoven dendritic processes of follicular dendritic cell sarcoma demonstrated on ultrafast papanicolaou-stained smears: a case report. (17017440)
2006
33
Follicular dendritic cell sarcoma of lymph node--a rare entity. (16696516)
2006
34
Nodal follicular dendritic cell sarcoma of the axilla presenting as cellulitis. (16403115)
2006
35
Follicular dendritic cell sarcoma mimicking giant cell carcinoma of the pancreas. (16872443)
2006
36
Paraneoplastic pemphigus associated with follicular dendritic cell sarcoma and Castleman disease. (16029358)
2005
37
Autoantibody production from a thymoma and a follicular dendritic cell sarcoma associated with paraneoplastic pemphigus. (16120143)
2005
38
Follicular dendritic cell sarcoma: case report and review of current management principles. (16343408)
2005
39
Symptoms in cancer patients and an unusual tumor: Case 3. Follicular dendritic cell sarcoma. (16361643)
2005
40
Metastatic follicular dendritic cell sarcoma of the stomach: a case report and review of the literature. (15285580)
2004
41
Intracranial follicular dendritic cell sarcoma. Case report. (14705740)
2003
42
Follicular dendritic cell sarcoma of the neck; a case report and literature review. (12393051)
2002
43
Fine needle aspiration cytology of follicular dendritic cell sarcoma. Report of a case with cytologic detection in an extranodal site. (11015984)
2000
44
Follicular dendritic cell sarcoma of the neck: report of two cases complicated by pulmonary metastases. (10931467)
2000
45
Extranodal follicular dendritic cell sarcoma of the palate. (10052377)
1999
46
Myxoid variant of follicular dendritic cell sarcoma arising in the breast. (10196389)
1999
47
Follicular dendritic cell sarcoma and interdigitating reticulum cell sarcoma: a review. (9766802)
1998
48
Follicular dendritic cell sarcoma. Clinicopathologic analysis of 17 cases suggesting a malignant potential higher than currently recognized. (9010103)
1997
49
Follicular dendritic cell sarcoma mimicking diffuse large cell lymphoma: a case report. (9256295)
1997
50
Follicular dendritic cell sarcoma complicated by hyaline-vascular type Castleman's disease in a schizophrenic patient. (9361105)
1997

Variations for Follicular Dendritic Cell Sarcoma

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Expression for genes affiliated with Follicular Dendritic Cell Sarcoma

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Expression patterns in normal tissues for genes affiliated with Follicular Dendritic Cell Sarcoma

Search GEO for disease gene expression data for Follicular Dendritic Cell Sarcoma.

Pathways for genes affiliated with Follicular Dendritic Cell Sarcoma

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Pathways related to Follicular Dendritic Cell Sarcoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Immune response Alternative complement pathway60
Immune response Lectin Induced complement pathway60
Immune response Classic complement pathway60
9.6CLU, CR1, CR2
29.6VIM, DSP, CLDN1
39.4FCER2, IL2RA, CR1, CR2
4
Show member pathways
9.3CR2, IL2RA, FCER2, TP53
59.2TP53, FCER2, VIM, CR2
6
Show member pathways
9.0DSP, DSG1, DSG3, VIM
79.0EVPL, VIM, DSP, PPL
8
Show member pathways
Proteasome Degradation37
Immune response Antigen presentation by MHC class I60
8.6VIM, DSG3, DSG1, DSP, TP53
9
Show member pathways
8.3DSP, VIM, CXCL13, IL2RA, TP53

Compounds for genes affiliated with Follicular Dendritic Cell Sarcoma

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Compounds related to Follicular Dendritic Cell Sarcoma according to GeneCards/GeneDecks:

(show all 50)
idCompoundScoreTop Affiliating Genes
1cr2+4410.3CR2, CR1
2mycophenolate sodium4410.2CR1, IL2RA
3okt34410.1FCER2, IL2RA, CR2
4tunicamycin44 6111.1SLC2A1, CLU, FCER2
5toxin a4410.0DSG3, DSG1
6asulam4410.0DSP, PPL
7cytochalasin b4410.0FCER2, VIM, SLC2A1
8aristolochic acid44 211.0TP53, VIM
9mannose449.8FCER2, CR1, SLC2A1
10temozolomide44 1110.8TP53, VIM
11calcitriol44 61 24 1112.8SLC2A1, IL2RA, CLU, FCER2
12ivig449.8IL2RA, DSG3, DSG1
13folate449.7IL2RA, VIM, CLU
14fmlp449.7FCER2, VIM, CR1
15vincristine44 50 1111.7IL2RA, VIM, TP53
16cytarabine44 50 1111.7CR1, VIM, TP53
17lactate449.6SLC2A1, VIM, CLU, FCER2
18formaldehyde44 2410.6CR1, IL2RA, VIM, FCER2
19prednisolone44 28 1111.6DSG3, IL2RA, CR1
20genistein44 28 61 2 24 1114.6FCER2, VIM, IL2RA, SLC2A1
21dmso449.6CR1, VIM, DSP
22thymidine44 2410.6TP53, FCER2, CLU, IL2RA
23vitamin d449.6CLU, VIM, IL2RA, CR1
24butyrate449.5TP53, CLU, VIM, SLC2A1
25etoposide44 50 61 1112.5TP53, CLU, VIM, IL2RA
26actinomycin d449.5TP53, CLU, VIM, SLC2A1
27cisplatin44 50 61 1112.5SLC2A1, IL2RA, CLU, TP53
28doxorubicin44 50 1111.5TP53, CLU, VIM, IL2RA
2912-o-tetradecanoylphorbol 13-acetate449.5FSCN1, VIM, DSP, FCER2
30gnrh449.4CLU, VIM, IL2RA
315-aza-2deoxycytidine449.4TP53, CLU, VIM, SNCG
32dexamethasone44 50 28 1112.4SLC2A1, IL2RA, VIM, CLU, FCER2
33acetylcholine44 50 28 24 1113.4DSG1, DSG3, VIM, IL2RA
34agar449.3SLC2A1, SNCG, VIM
35adenylate449.3SLC2A1, CR1, IL2RA, VIM
36heparin44 28 24 1112.3CLU, VIM, IL2RA, CR1, SLC2A1
37atp44 2810.3FCER2, CLU, VIM, CR1, SLC2A1
38cysteine449.3SLC2A1, IL2RA, VIM, CLU, FCER2
39progesterone44 28 61 24 1113.2TP53, CLU, DSP, VIM
40vegf449.2TP53, CLU, VIM, IL2RA, SLC2A1
415fluorouracil449.1SLC2A1, IL2RA, TP53
42h2o2449.1IL2RA, VIM, CLU, TP53
43paclitaxel44 50 1111.1TP53, CLU, VIM, IL2RA, SNCG
44cycloheximide448.8TP53, FCER2, CLU, VIM, CR1, CR2
45estrogen448.6TP53, CLU, VIM, IL2RA, SNCG, CR2
46retinoic acid44 249.2TP53, FCER2, CLU, DSP, DSG1, VIM
47paraffin447.9SLC2A1, TP53, FCER2, CLU, VIM, FSCN1
48serine447.5TP53, FCER2, CLU, DSP, DSG1, DSG3
49tyrosine447.5DSG3, DSP, CLU, FCER2, FSCN1, IL2RA
50calcium44 50 24 119.8DSP, CLU, CLDN1, FCER2, DSG1, DSG3

GO Terms for genes affiliated with Follicular Dendritic Cell Sarcoma

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Cellular components related to Follicular Dendritic Cell Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.7CR2, IL2RA, FCER2
2cornified envelopeGO:0015339.7DSP, EVPL
3desmosomeGO:0300578.6PPL, DSP, DSG1, DSG3, EVPL
4plasma membraneGO:0058866.4PPL, FCER2, DSP, DSG1, DSG3, VIM
5extracellular vesicular exosomeGO:0700626.2SLC2A1, PPL, FCER2, CLU, DSP, DSG3

Biological processes related to Follicular Dendritic Cell Sarcoma according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1intermediate filament organizationGO:0451099.9DSP, VIM
2peptide cross-linkingGO:0181499.9DSP, EVPL
3positive regulation of intrinsic apoptotic signaling pathwayGO:20012449.8CLU, TP53
4complement activation, classical pathwayGO:0069589.8CR2, CR1, CLU
5cellular response to glucose starvationGO:0421499.8SLC2A1, TP53
6Notch signaling pathwayGO:0072199.6IL2RA, FCER2, TP53
7release of cytochrome c from mitochondriaGO:0018369.5CLU, TP53
8cellular component disassembly involved in execution phase of apoptosisGO:0069219.2VIM, DSG3, DSG1, DSP
9apoptotic processGO:0069158.5TP53, DSP, DSG1, DSG3, VIM, IL2RA

Molecular functions related to Follicular Dendritic Cell Sarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1structural molecule activityGO:0051989.7EVPL, DSP, CLDN1
2structural constituent of cytoskeletonGO:0052009.6DSP, PPL
3protein binding, bridgingGO:0306749.5EVPL, FSCN1, DSP
4scaffold protein bindingGO:0971109.5VIM, DSP
5identical protein bindingGO:0428029.1TP53, CLDN1, VIM, SLC2A1

Products for genes affiliated with Follicular Dendritic Cell Sarcoma

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Sources for Follicular Dendritic Cell Sarcoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet