MCID: FLL037
MIFTS: 48

Follicular Lymphoma malady

Rare diseases, Cancer diseases, Immune diseases categories
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Summaries for Follicular Lymphoma

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Disease Ontology:8 A non-hodgkin lymphoma that is characterized as an indolent non-hodgkin's lymphoma and has material basis in follicle center b-cells (centrocytes and centroblasts).

MalaCards based summary: Follicular Lymphoma, also known as lymphoma, follicular, is related to b-cell lymphomas and mantle cell lymphoma. An important gene associated with Follicular Lymphoma is BCL2 (B-cell CLL/lymphoma 2), and among its related pathways are Complement Pathway and Selected targets of p53. The drug ibritumomab tiuxetan has been mentioned in the context of this disorder. Affiliated tissues include b cells, t cells and bone.

Wikipedia:65 Follicular lymphoma is the most common of the indolent non-Hodgkin\'s lymphomas, and the... more...

Aliases & Classifications for Follicular Lymphoma

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Follicular Lymphoma, Aliases & Descriptions:

Name: Follicular Lymphoma 30 8 42
Lymphoma, Follicular 42 62
 
Lymphoma Follicular 44


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Immune diseases


External Ids:

Disease Ontology8 DOID:0050873
ICD1025 C82

Related Diseases for Follicular Lymphoma

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Diseases in the Follicular Lymphoma family:

Follicular Lymphoma 1

Diseases related to Follicular Lymphoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 107)
idRelated DiseaseScoreTop Affiliating Genes
1b-cell lymphomas31.1BCL2, IGHM, BCL6, IGH
2mantle cell lymphoma30.9BCL2, BCL6
3hodgkin's lymphoma30.7MSC
4chronic lymphocytic leukemia30.6BCL2, BCL6, IGHM, IGH
5central nervous system lymphoma30.6BCL6
6malt lymphoma30.5IGHM, BCL2, BCL6, IGH
7non-hodgkin lymphoma30.3BCL6, IGH, BCL2
8burkitt's lymphoma30.2BCL6, IGHM, IGH, BCL2
9acute lymphoblastic leukemia29.9BCL2, BCL6, IGH
10diffuse large b-cell lymphoma10.7
11leukemia10.6
12duodenitis10.5
13hematopoietic stem cell transplantation10.5
14sarcoma10.4
15pemphigus10.4
16paraneoplastic pemphigus10.4
17progressive multifocal leukoencephalopathy10.3
18gastric lymphoma10.3BCL6, IGH
19lymphoblastic lymphoma10.3
20peripheral t-cell lymphoma10.3
21dendritic cell sarcoma10.3
22eosinophilia10.3
23lymphoblastic leukemia10.3
24progressive transformation of germinal centers10.3
25lymphoma, follicular, somatic10.3
26histiocytic sarcoma10.3
27lymphosarcoma10.2IGH, BCL2, BCL6
28plasmacytoma10.2BCL6, IGH
29reticulosarcoma10.2IGH, BCL6, BCL2
30lymphomatoid granulomatosis10.2
31follicular mucinosis10.2
32protein-losing enteropathy10.2
33endometrial carcinoma10.2
34mediastinitis10.2
35psoriasis10.2
36thyroiditis10.2
37lymphoma, small cleaved-cell, follicular10.2
38plasmablastic lymphoma10.2
39primary effusion lymphoma10.2
40splenomegaly10.2
41transient acantholytic dermatosis10.2
42follicular lymphoma 110.2
43diffuse large b-cell lymphoma with chronic inflammation10.2
44nodal marginal zone b-cell lymphoma10.2
45central nervous system lymphoma, primary10.2BCL6, IGHM
46macroglobulinemia, waldenstrom, somatic10.1IGHM, IGH
47anaplastic large cell lymphoma10.0
48atherosclerosis10.0
49colorectal cancer10.0
50crohn's disease10.0

Graphical network of the top 20 diseases related to Follicular Lymphoma:



Diseases related to follicular lymphoma

Symptoms for Follicular Lymphoma

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Drugs & Therapeutics for Follicular Lymphoma

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Drug clinical trials:

Search ClinicalTrials for Follicular Lymphoma

Search NIH Clinical Center for Follicular Lymphoma

Inferred drug relations via UMLS62/NDF-RT40:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Follicular Lymphoma cell therapies at LifeMap Discovery.

Genetic Tests for Follicular Lymphoma

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Anatomical Context for Follicular Lymphoma

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MalaCards organs/tissues related to Follicular Lymphoma:

32
B cells, T cells, Bone, Lymph node, Bone marrow, Colon, Breast, Testis, Monocytes, B lymphoblasts, Small intestine, Thyroid, Skin, Liver, Lung, Salivary gland, Nk cells, Endothelial

Animal Models for Follicular Lymphoma or affiliated genes

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Publications for Follicular Lymphoma

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Articles related to Follicular Lymphoma:

(show top 50)    (show all 800)
idTitleAuthorsYear
1
Consolidation treatment with Yttrium-90 ibritumomab tiuxetan after new induction regimen in patients with intermediate- and high-risk follicular lymphoma according to the follicular lymphoma international prognostic index: a multicenter, prospective phase II trial of the Spanish Lymphoma Oncology Group. (23573825)
2014
2
Milatuzumab and veltuzumab induce apoptosis through JNK signalling in an NF-I_B dependent human transformed follicular lymphoma cell line. (24386925)
2014
3
Genetics of Follicular Lymphoma Transformation. (24388756)
2014
4
X chromosome-wide association study of follicular lymphoma. (23795672)
2013
5
Soluble interleukin-2 receptor level predicts survival in patients with follicular lymphoma treated with CHOP chemotherapy in the rituximab era. (24180329)
2013
6
Synchronous adenocarcinoma and follicular lymphoma of the stomach. (23583995)
2013
7
Peripheral blood involvement in patients with follicular lymphoma: a rare disease manifestation associated with poor prognosis. (24274024)
2013
8
Coding variants at hexa-allelic amino acid 13 of HLA-DRB1 explain independent SNP associations with follicular lymphoma risk. (23791106)
2013
9
Rituximab maintenance or retreatment after autologous transplantation for relapsed follicular lymphoma? (24062390)
2013
10
The outcome of reduced intensity allogeneic stem cell transplantation and autologous stem cell transplantation when performed as a first transplant strategy in relapsed follicular lymphoma: an analysis from the Lymphoma Working Party of the EBMT. (23771004)
2013
11
Chemotherapy versus autologous stem-cell transplantation for the treatment of transformed follicular lymphoma in the rituximab era. (23918946)
2013
12
Long-term follow-up of reduced-intensity allogeneic hematopoietic stem cell transplantation for refractory or relapsed follicular lymphoma. (22674621)
2012
13
Imaging follicular lymphoma using positron emission tomography with [(18)F]fluorodeoxyglucose: to what purpose? (23109690)
2012
14
Is autologous stem cell transplantation for transformed follicular lymphoma still justifiable? (22239667)
2012
15
Long-term outcome after autologous or allogeneic stem cell transplantation in patients with recurrent follicular lymphoma. (22327132)
2012
16
Has the time to come leave the "watch-and-wait" strategy in newly diagnosed asymptomatic follicular lymphoma patients? (22650448)
2012
17
Severe CMV reactivation and gastritis during treatment of follicular lymphoma with bendamustine. (21811782)
2012
18
Is there a role for "watch and wait" in follicular lymphoma in the rituximab era? (23233615)
2012
19
In situ follicular lymphoma with progressive transformation of the germinal centers confirmed by laser capture microdissection, IGH gene rearrangement analysis, and fluorescence in situ hybridization for t(14;18). (21733560)
2012
20
Precision of histological bone marrow staging in follicular lymphoma and diffuse large B-cell lymphoma. (23217561)
2012
21
Clinical significance of the WHO grades of follicular lymphoma in a population-based cohort of 505 patients with long follow-up times. (22126847)
2012
22
High frequency of t(14;18) in Hodgkin's lymphoma associated with follicular lymphoma. (22827759)
2012
23
High-dose therapy with autologous stem cell transplantation versus chemotherapy or immuno-chemotherapy for follicular lymphoma in adults. (22258971)
2012
24
Prognostic factors in follicular lymphoma in the rituximab era: how to identify a high-risk patient? (21804618)
2011
25
Preferences of patients and physicians concerning treatment options for relapsed follicular lymphoma: a discrete choice experiment. (20935681)
2011
26
BIOMED-2 PCR assays for IGK gene rearrangements are essential for B-cell clonality analysis in follicular lymphoma. (21790530)
2011
27
An unusual presentation of follicular lymphoma. (20952121)
2011
28
Biology and treatment of follicular lymphoma. (21083019)
2009
29
Value of loss of CD10 expression in pathologic diagnosis of follicular lymphoma]. (20079015)
2009
30
A proliferation-inducing ligand mediates follicular lymphoma B-cell proliferation and cyclin D1 expression through phosphatidylinositol 3-kinase-regulated mammalian target of rapamycin activation. (19321861)
2009
31
PKC zeta mTOR pathway: a new target for rituximab therapy in follicular lymphoma. (17855629)
2008
32
Transient acantholytic dermatosis associated with B symptoms of follicular lymphoma. (17868396)
2007
33
Proteome- and microarray-based expression analysis of lymphoma cell lines identifies a p53-centered cluster of differentially expressed proteins in mantle cell and follicular lymphoma. (17990259)
2007
34
Human follicular lymphoma cells contain oligomannose glycans in the antigen-binding site of the B-cell receptor. (17197448)
2007
35
Variation in DNA repair genes ERCC2, XRCC1, and XRCC3 and risk of follicular lymphoma. (16492913)
2006
36
Primary mediastinal B-cell lymphoma: hypermutation of the BCL6 gene targets motifs different from those in diffuse large B-cell and follicular lymphomas. (15377470)
2004
37
Detection of BCL2-IGH rearrangement on paraffin-embedded tissue sections obtained from a small submucosal tumor of the rectum in a patient with recurrent follicular lymphoma. (15300917)
2004
38
Similarities of prosurvival signals in Bcl-2-positive and Bcl-2-negative follicular lymphomas identified by reverse phase protein microarray. (14767488)
2004
39
Establishment and comprehensive analysis of a new human transformed follicular lymphoma B cell line, Tat-1. (11840295)
2002
40
Gene expression profiling of follicular lymphoma and normal germinal center B cells using cDNA arrays. (11756183)
2002
41
In situ localization of follicular lymphoma: description and analysis by laser capture microdissection. (11964306)
2002
42
Insights into the molecular pathogenesis of follicular lymphoma arising from analysis of geographic variation. (12036852)
2002
43
Variable heavy-chain gene analysis of follicular lymphomas: subclone selection rather than clonal evolution over time. (11418487)
2001
44
Association of a duodenal follicular lymphoma and hereditary nonpolyposis colorectal cancer. (10824932)
2000
45
Somatic mutations of the translocated bcl-2 gene are associated with morphologic transformation of follicular lymphoma to diffuse large-cell lymphoma. (9209654)
1997
46
Detection of the t(14;18) chromosomal translocation by interphase cytogenetics with yeast-artificial-chromosome probes in follicular lymphoma and nonneoplastic lymphoproliferation. (8622046)
1996
47
A human follicular lymphoma B cell line hypermutates its functional immunoglobulin genes in vitro. (8566010)
1995
48
MYC rearrangements in histologically progressed follicular lymphomas. (1638027)
1992
49
CD30 expression in follicular lymphoma. (1849500)
1991
50
Radioimmunotherapy in follicular lymphoma: some like it hota8 (21334979)
.

Variations for Follicular Lymphoma

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Expression for genes affiliated with Follicular Lymphoma

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Expression patterns in normal tissues for genes affiliated with Follicular Lymphoma

Search GEO for disease gene expression data for Follicular Lymphoma.

Pathways for genes affiliated with Follicular Lymphoma

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Pathways related to Follicular Lymphoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Immune response Alternative complement pathway60
Immune response Lectin Induced complement pathway60
Immune response Classic complement pathway60
9.8IGH, IGHM
29.8BCL2, BCL6
39.5BCL2, BCL6, IGHM
4
Show member pathways
Immune response BCR pathway60
Fc-epsilon receptor I signaling in mast cells37
9.3BCL6, IGH, IGHM

Compounds for genes affiliated with Follicular Lymphoma

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GO Terms for genes affiliated with Follicular Lymphoma

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Biological processes related to Follicular Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of G1/S transition of mitotic cell cycleGO:20001349.8ZC3H12D, BCL2
2positive regulation of B cell proliferationGO:0308909.8BCL2, BCL6
3defense response to Gram-negative bacteriumGO:0508299.6TNFRSF14, IGHM
4negative regulation of cell growthGO:0303089.5ZC3H12D, BCL2, BCL6

Molecular functions related to Follicular Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1antigen bindingGO:0038239.7IGHM, IGKV1-5

Products for genes affiliated with Follicular Lymphoma

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Sources for Follicular Lymphoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet