MCID: FLL037
MIFTS: 46

Follicular Lymphoma malady

Rare diseases, Cancer diseases, Immune diseases categories

Summaries for Follicular Lymphoma

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66Wikipedia, 34MalaCards
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Wikipedia:66 Follicular lymphoma is the most common of the indolent non-Hodgkin\'s lymphomas, and the... more...

MalaCards: Follicular Lymphoma, also known as lymphoma, follicular, is related to b-cell lymphomas and chronic lymphocytic leukemia. An important gene associated with Follicular Lymphoma is BCL2 (B-cell CLL/lymphoma 2), and among its related pathways are Complement Pathway and Selected targets of p53. The drug ibritumomab tiuxetan has been mentioned in the context of this disorder. Affiliated tissues include b cells, t cells and bone.

Aliases & Classifications for Follicular Lymphoma

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9Disease Ontology, 44NIH Rare Diseases, 32LifeMap Discoveryā„¢, 63UMLS, 46Novoseek, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Immune diseases


Aliases & Descriptions:

follicular lymphoma 9 44 32
lymphoma, follicular 44 63
lymphoma follicular 46


External Ids:

Disease Ontology9 DOID:0050873
ICD1026 C82

Related Diseases for Follicular Lymphoma

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Sources:
18GeneCards, 19GeneDecks
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Diseases in the Follicular Lymphoma family:

Follicular Lymphoma 1

Diseases related to Follicular Lymphoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 101)
idRelated DiseaseScoreTop Affiliating Genes
1b-cell lymphomas31.2BCL2, IGHM, BCL6, IGH
2chronic lymphocytic leukemia30.7BCL2, BCL6, IGHM, IGH
3mantle cell lymphoma30.6BCL2, BCL6
4malt lymphoma30.5IGHM, BCL2, BCL6, IGH
5burkitt's lymphoma30.5BCL6, IGHM, IGH, BCL2
6hodgkin's lymphoma30.4MSC
7non-hodgkin lymphoma30.3BCL6, IGH, BCL2
8central nervous system lymphoma30.1BCL6
9lymphoma, diffuse large cell30.1BCL2, BCL6
10diffuse large b-cell lymphoma10.7
11leukemia10.5
12duodenitis10.5
13hematopoietic stem cell transplantation10.4
14sarcoma10.4
15pemphigus10.3
16progressive multifocal leukoencephalopathy10.3
17paraneoplastic pemphigus10.3
18dendritic cell sarcoma10.2
19lymphoblastic leukemia10.2
20lymphoblastic lymphoma10.2
21progressive transformation of germinal centers10.2
22lymphoma, follicular, somatic10.2
23protein-losing enteropathy10.2
24follicular mucinosis10.2
25composite lymphoma10.2
26endometrial carcinoma10.2
27eosinophilia10.2
28mediastinitis10.2
29psoriasis10.2
30thyroiditis10.2
31lymphoma, small cleaved-cell, follicular10.2
32lymphomatoid granulomatosis10.2
33peripheral t-cell lymphoma10.2
34plasmablastic lymphoma10.2
35primary effusion lymphoma10.2
36splenomegaly10.2
37transient acantholytic dermatosis10.2
38follicular lymphoma 110.2
39diffuse large b-cell lymphoma with chronic inflammation10.2
40histiocytic sarcoma10.2
41nodal marginal zone b-cell lymphoma10.2
42gastric lymphoma10.1BCL6, IGH
43lymphosarcoma10.0IGH, BCL2, BCL6
44reticulosarcoma10.0IGH, BCL6, BCL2
45central nervous system lymphoma, primary10.0BCL6, IGHM
46plasmacytoma10.0BCL6, IGH
47macroglobulinemia, waldenstrom, somatic10.0IGHM, IGH
48crohn's disease10.0
49neuromyelitis optica10.0
50richter's syndrome10.0

Graphical network of the top 20 diseases related to Follicular Lymphoma:



Diseases related to follicular lymphoma

Symptoms for Follicular Lymphoma

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Drugs & Therapeutics for Follicular Lymphoma

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 32LifeMap Discoveryā„¢, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Follicular Lymphoma

Drug clinical trials:

Search ClinicalTrials for Follicular Lymphoma

Search NIH Clinical Center for Follicular Lymphoma

Search CenterWatch for Follicular Lymphoma

Inferred drug relations via UMLS63/NDF-RT42:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Follicular Lymphoma cell therapies at LifeMap Discovery.

Genetic Tests for Follicular Lymphoma

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Anatomical Context for Follicular Lymphoma

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34MalaCards
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MalaCards organs/tissues related to Follicular Lymphoma:

34
B cells, T cells, Bone, Bone marrow, Lymph node, Colon, Monocytes, Testis, Breast, B lymphoblasts, Skin, Small intestine, Thyroid, Nk cells, Lung

Animal Models for Follicular Lymphoma or affiliated genes

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Publications for Follicular Lymphoma

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53PubMed
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Articles related to Follicular Lymphoma:

(show top 50)    (show all 765)
idTitleAuthorsYear
1
Consolidation treatment with Yttrium-90 ibritumomab tiuxetan after new induction regimen in patients with intermediate- and high-risk follicular lymphoma according to the follicular lymphoma international prognostic index: a multicenter, prospective phase II trial of the Spanish Lymphoma Oncology Group. (23573825)
2014
2
Milatuzumab and veltuzumab induce apoptosis through JNK signalling in an NF-I_B dependent human transformed follicular lymphoma cell line. (24386925)
2014
3
Genetics of Follicular Lymphoma Transformation. (24388756)
2014
4
X chromosome-wide association study of follicular lymphoma. (23795672)
2013
5
Soluble interleukin-2 receptor level predicts survival in patients with follicular lymphoma treated with CHOP chemotherapy in the rituximab era. (24180329)
2013
6
Synchronous adenocarcinoma and follicular lymphoma of the stomach. (23583995)
2013
7
Peripheral blood involvement in patients with follicular lymphoma: a rare disease manifestation associated with poor prognosis. (24274024)
2013
8
Coding variants at hexa-allelic amino acid 13 of HLA-DRB1 explain independent SNP associations with follicular lymphoma risk. (23791106)
2013
9
Rituximab maintenance or retreatment after autologous transplantation for relapsed follicular lymphoma? (24062390)
2013
10
The outcome of reduced intensity allogeneic stem cell transplantation and autologous stem cell transplantation when performed as a first transplant strategy in relapsed follicular lymphoma: an analysis from the Lymphoma Working Party of the EBMT. (23771004)
2013
11
Long-term follow-up of reduced-intensity allogeneic hematopoietic stem cell transplantation for refractory or relapsed follicular lymphoma. (22674621)
2012
12
Imaging follicular lymphoma using positron emission tomography with [(18)F]fluorodeoxyglucose: to what purpose? (23109690)
2012
13
Is autologous stem cell transplantation for transformed follicular lymphoma still justifiable? (22239667)
2012
14
Long-term outcome after autologous or allogeneic stem cell transplantation in patients with recurrent follicular lymphoma. (22327132)
2012
15
Has the time to come leave the "watch-and-wait" strategy in newly diagnosed asymptomatic follicular lymphoma patients? (22650448)
2012
16
Severe CMV reactivation and gastritis during treatment of follicular lymphoma with bendamustine. (21811782)
2012
17
Is there a role for "watch and wait" in follicular lymphoma in the rituximab era? (23233615)
2012
18
In situ follicular lymphoma with progressive transformation of the germinal centers confirmed by laser capture microdissection, IGH gene rearrangement analysis, and fluorescence in situ hybridization for t(14;18). (21733560)
2012
19
Precision of histological bone marrow staging in follicular lymphoma and diffuse large B-cell lymphoma. (23217561)
2012
20
Clinical significance of the WHO grades of follicular lymphoma in a population-based cohort of 505 patients with long follow-up times. (22126847)
2012
21
High frequency of t(14;18) in Hodgkin's lymphoma associated with follicular lymphoma. (22827759)
2012
22
High-dose therapy with autologous stem cell transplantation versus chemotherapy or immuno-chemotherapy for follicular lymphoma in adults. (22258971)
2012
23
Prognostic factors in follicular lymphoma in the rituximab era: how to identify a high-risk patient? (21804618)
2011
24
Preferences of patients and physicians concerning treatment options for relapsed follicular lymphoma: a discrete choice experiment. (20935681)
2011
25
BIOMED-2 PCR assays for IGK gene rearrangements are essential for B-cell clonality analysis in follicular lymphoma. (21790530)
2011
26
An unusual presentation of follicular lymphoma. (20952121)
2011
27
Biology and treatment of follicular lymphoma. (21083019)
2009
28
Value of loss of CD10 expression in pathologic diagnosis of follicular lymphoma]. (20079015)
2009
29
A proliferation-inducing ligand mediates follicular lymphoma B-cell proliferation and cyclin D1 expression through phosphatidylinositol 3-kinase-regulated mammalian target of rapamycin activation. (19321861)
2009
30
PKC zeta mTOR pathway: a new target for rituximab therapy in follicular lymphoma. (17855629)
2008
31
Transient acantholytic dermatosis associated with B symptoms of follicular lymphoma. (17868396)
2007
32
Proteome- and microarray-based expression analysis of lymphoma cell lines identifies a p53-centered cluster of differentially expressed proteins in mantle cell and follicular lymphoma. (17990259)
2007
33
Human follicular lymphoma cells contain oligomannose glycans in the antigen-binding site of the B-cell receptor. (17197448)
2007
34
Variation in DNA repair genes ERCC2, XRCC1, and XRCC3 and risk of follicular lymphoma. (16492913)
2006
35
Primary mediastinal B-cell lymphoma: hypermutation of the BCL6 gene targets motifs different from those in diffuse large B-cell and follicular lymphomas. (15377470)
2004
36
Detection of BCL2-IGH rearrangement on paraffin-embedded tissue sections obtained from a small submucosal tumor of the rectum in a patient with recurrent follicular lymphoma. (15300917)
2004
37
Similarities of prosurvival signals in Bcl-2-positive and Bcl-2-negative follicular lymphomas identified by reverse phase protein microarray. (14767488)
2004
38
Genetic and molecular genetic studies in the diagnosis of B-cell lymphomas I: mantle cell lymphoma, follicular lymphoma, and Burkitt's lymphoma. (12733111)
2003
39
Establishment and comprehensive analysis of a new human transformed follicular lymphoma B cell line, Tat-1. (11840295)
2002
40
Gene expression profiling of follicular lymphoma and normal germinal center B cells using cDNA arrays. (11756183)
2002
41
In situ localization of follicular lymphoma: description and analysis by laser capture microdissection. (11964306)
2002
42
Insights into the molecular pathogenesis of follicular lymphoma arising from analysis of geographic variation. (12036852)
2002
43
Variable heavy-chain gene analysis of follicular lymphomas: subclone selection rather than clonal evolution over time. (11418487)
2001
44
Association of a duodenal follicular lymphoma and hereditary nonpolyposis colorectal cancer. (10824932)
2000
45
Somatic mutations of the translocated bcl-2 gene are associated with morphologic transformation of follicular lymphoma to diffuse large-cell lymphoma. (9209654)
1997
46
Detection of the t(14;18) chromosomal translocation by interphase cytogenetics with yeast-artificial-chromosome probes in follicular lymphoma and nonneoplastic lymphoproliferation. (8622046)
1996
47
A human follicular lymphoma B cell line hypermutates its functional immunoglobulin genes in vitro. (8566010)
1995
48
CD30 expression in follicular lymphoma. (1849500)
1991
49
Activation of the c-myc oncogene in a precursor-B-cell blast crisis of follicular lymphoma, presenting as composite lymphoma. (3285208)
1988
50
Radioimmunotherapy in follicular lymphoma: some like it hota8 (21334979)
.

Variations for Follicular Lymphoma

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Expression for genes affiliated with Follicular Lymphoma

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Follicular Lymphoma

Search GEO for disease gene expression data for Follicular Lymphoma.

Pathways for genes affiliated with Follicular Lymphoma

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Sources:
51PathCards, 54QIAGEN, 61Thomson Reuters, 56Reactome, 58SinoBiological, 13EMD Millipore, 39NCBI BioSystems Database, 55R&D Systems, 31KEGG
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Pathways related to Follicular Lymphoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Immune response Alternative complement pathway61
Immune response Lectin Induced complement pathway61
Immune response Classic complement pathway61
9.8IGH, IGHM
29.8BCL2, BCL6
39.5BCL2, BCL6, IGHM
4
Show member pathways
Immune response BCR pathway61
Fc-epsilon receptor I signaling in mast cells39
9.3BCL6, IGH, IGHM

Compounds for genes affiliated with Follicular Lymphoma

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GO Terms for genes affiliated with Follicular Lymphoma

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17Gene Ontology
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Biological processes related to Follicular Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of G1/S transition of mitotic cell cycleGO:20001349.8ZC3H12D, BCL2
2positive regulation of B cell proliferationGO:0308909.8BCL2, BCL6
3defense response to Gram-negative bacteriumGO:0508299.6TNFRSF14, IGHM
4negative regulation of cell growthGO:0303089.5ZC3H12D, BCL2, BCL6

Molecular functions related to Follicular Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1antigen bindingGO:0038239.7IGHM, IGKV1-5

Products for genes affiliated with Follicular Lymphoma

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Sources for Follicular Lymphoma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet