MCID: FLL037
MIFTS: 50

Follicular Lymphoma malady

Rare diseases, Cancer diseases, Blood diseases, Immune diseases categories

Aliases & Classifications for Follicular Lymphoma

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Sources:
30LifeMap Discovery®, 9Disease Ontology, 41NIH Rare Diseases, 47Orphanet, 60UMLS, 43Novoseek, 34MESH via Orphanet, 26ICD10 via Orphanet, 61UMLS via Orphanet, 25ICD10
See all sources

Follicular Lymphoma, Aliases & Descriptions:

Name: Follicular Lymphoma 30 9 41 47
Lymphoma, Follicular 41 60
 
Lymphoma Follicular 43


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Blood diseases, Immune diseases


Characteristics (Orphanet epidemiological data):

47
follicular lymphoma:
Inheritance: Multigenic/multifactorial,Not applicable; Prevalence: 1-5/10000 (Europe),1-9/100000 (France); Age of onset: Adult; Age of death: adult


External Ids:

Disease Ontology9 DOID:0050873
Orphanet47 545
MESH via Orphanet34 D008224
ICD10 via Orphanet26 C82
UMLS via Orphanet61 C0024301
ICD1025 C82

Summaries for Follicular Lymphoma

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Disease Ontology:9 A non-hodgkin lymphoma that is characterized as an indolent non-hodgkin's lymphoma and has material basis in follicle center b-cells (centrocytes and centroblasts).

MalaCards based summary: Follicular Lymphoma, also known as lymphoma, follicular, is related to b-cell lymphomas and mantle cell lymphoma, and has symptoms including hyperhidrosis, weight loss and abnormality of temperature regulation. An important gene associated with Follicular Lymphoma is BCL2 (B-cell CLL/lymphoma 2), and among its related pathways are B Cell Receptor Signaling Pathway and Immune response Fc epsilon RI pathway. The drug ibritumomab tiuxetan has been mentioned in the context of this disorder. Affiliated tissues include b cells, bone and t cells, and related mouse phenotype immune system.

Wikipedia:63 Follicular lymphoma is the most common of the indolent non-Hodgkin\'s lymphomas, and the... more...

Related Diseases for Follicular Lymphoma

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Diseases related to Follicular Lymphoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 114)
idRelated DiseaseScoreTop Affiliating Genes
1b-cell lymphomas31.5BCL2, BCL6, C6orf25, IGHM, IGH
2mantle cell lymphoma31.2BCL2, BCL6
3hodgkin lymphoma31.1MSC
4malt lymphoma31.0IGH, IGHM, BCL6, BCL2
5chronic lymphocytic leukemia31.0IGH, IGHM, BCL6, BCL2, CD70
6burkitt lymphoma30.8BCL2, BCL6
7central nervous system lymphoma30.7BCL6
8diffuse large b-cell lymphoma10.8
9leukemia10.6
10duodenitis10.5
11hematopoietic stem cell transplantation10.5
12sarcoma10.4
13gastric lymphoma10.4IGH, BCL6
14lymphosarcoma10.4IGH, BCL6, BCL2
15central nervous system lymphoma, primary10.4IGHM, BCL6
16pemphigus10.4
17paraneoplastic pemphigus10.4
18squamous cell carcinoma, head and neck10.4BCL2, IGHM, IGH
19reticulosarcoma10.4BCL2, BCL6, IGH
20waldenstrom macroglobulinemia10.3IGHM, IGH
21chromosomal triplication10.3BCL6, IGHM, IGH
22lymphoma, follicular, somatic10.3
23progressive multifocal leukoencephalopathy10.3
24lymphoblastic lymphoma10.3
25dendritic cell sarcoma10.3
26eosinophilia10.3
27lymphoblastic leukemia10.3
28histiocytic sarcoma10.3
29leukemia, acute lymphoblastic10.2BCL2, BCL6, IGH
30plasmacytoma10.2BCL6, IGH
31myeloma10.2BCL2, BCL6, TNFRSF17, IGHM, IGH
32lymphomatoid granulomatosis10.2
33peripheral t-cell lymphoma10.2
34protein-losing enteropathy10.2
35follicular mucinosis10.2
36composite lymphoma10.2
37mediastinitis10.2
38psoriasis10.2
39thyroiditis10.2
40lymphoma, small cleaved-cell, follicular10.2
41plasmablastic lymphoma10.2
42primary effusion lymphoma10.2
43progressive transformation of germinal centers10.2
44splenomegaly10.2
45transient acantholytic dermatosis10.2
46nodal marginal zone b-cell lymphoma10.2
47narcolepsy10.1HLA-DRB1, IGHM
48hiv-110.1BCL6, TNFRSF17, IGHM
49colorectal cancer10.0
50kaposi sarcoma10.0

Graphical network of the top 20 diseases related to Follicular Lymphoma:



Diseases related to follicular lymphoma

Symptoms for Follicular Lymphoma

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Symptoms:

 47 (show all 14)
  • hyperhidrosis/increased sweating
  • lymphadenopathy/polyadenopathies
  • hematologic/blood/lymphatic cancer
  • weight loss/loss of appetite/break in weight curve/general health alteration
  • fever/chilling
  • splenomegaly
  • mediastinal/hilar adenopathies
  • asthenia/fatigue/weakness
  • anomalies of skin, subcutaneous tissue and mucosae
  • structural anomaly of the peritoneum
  • abnormal pleura/hydrothorax/pleuresia/pleural effusion/chylothorax
  • lymphedema
  • meningitis/meningeal syndrome
  • bone marrow/medullar infiltration

HPO human phenotypes related to Follicular Lymphoma:

(show all 10)
id Description Frequency HPO Source Accession
1 hyperhidrosis hallmark (90%) HP:0000975
2 weight loss hallmark (90%) HP:0001824
3 abnormality of temperature regulation hallmark (90%) HP:0004370
4 hematological neoplasm hallmark (90%) HP:0004377
5 splenomegaly typical (50%) HP:0001744
6 mediastinal lymphadenopathy typical (50%) HP:0100721
7 lymphedema occasional (7.5%) HP:0001004
8 meningitis occasional (7.5%) HP:0001287
9 abnormality of the pleura occasional (7.5%) HP:0002103
10 abnormality of the peritoneum occasional (7.5%) HP:0002585

Drugs & Therapeutics for Follicular Lymphoma

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Drug clinical trials:

Search ClinicalTrials for Follicular Lymphoma

Search NIH Clinical Center for Follicular Lymphoma

Inferred drug relations via UMLS60/NDF-RT39:

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Follicular Lymphoma cell therapies at LifeMap Discovery.

Genetic Tests for Follicular Lymphoma

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Anatomical Context for Follicular Lymphoma

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MalaCards organs/tissues related to Follicular Lymphoma:

31
B cells, Bone, T cells, Bone marrow, Lymph node, Skin, Colon, Breast, Monocytes, Testis, B lymphoblasts, Small intestine, Thyroid, Liver, Lung, Salivary gland, Nk cells, Endothelial

Animal Models for Follicular Lymphoma or affiliated genes

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MGI Mouse Phenotypes related to Follicular Lymphoma:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053879.0CD70, GCSAM, BCL2, BCL6, TNFRSF17, TNFRSF14

Publications for Follicular Lymphoma

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Articles related to Follicular Lymphoma:

(show top 50)    (show all 818)
idTitleAuthorsYear
1
Long-term follow-up of rituximab plus first-line mitoxantrone, chlorambucil, prednisolone and interferon-alpha as maintenance therapy in follicular lymphoma. (25804839)
2015
2
Consolidation treatment with Yttrium-90 ibritumomab tiuxetan after new induction regimen in patients with intermediate- and high-risk follicular lymphoma according to the follicular lymphoma international prognostic index: a multicenter, prospective phase II trial of the Spanish Lymphoma Oncology Group. (23573825)
2014
3
Milatuzumab and veltuzumab induce apoptosis through JNK signalling in an NF-I_B dependent human transformed follicular lymphoma cell line. (24386925)
2014
4
Genetics of Follicular Lymphoma Transformation. (24388756)
2014
5
X chromosome-wide association study of follicular lymphoma. (23795672)
2013
6
Soluble interleukin-2 receptor level predicts survival in patients with follicular lymphoma treated with CHOP chemotherapy in the rituximab era. (24180329)
2013
7
Synchronous adenocarcinoma and follicular lymphoma of the stomach. (23583995)
2013
8
Peripheral blood involvement in patients with follicular lymphoma: a rare disease manifestation associated with poor prognosis. (24274024)
2013
9
Coding variants at hexa-allelic amino acid 13 of HLA-DRB1 explain independent SNP associations with follicular lymphoma risk. (23791106)
2013
10
Rituximab maintenance or retreatment after autologous transplantation for relapsed follicular lymphoma? (24062390)
2013
11
The outcome of reduced intensity allogeneic stem cell transplantation and autologous stem cell transplantation when performed as a first transplant strategy in relapsed follicular lymphoma: an analysis from the Lymphoma Working Party of the EBMT. (23771004)
2013
12
Chemotherapy versus autologous stem-cell transplantation for the treatment of transformed follicular lymphoma in the rituximab era. (23918946)
2013
13
Long-term follow-up of reduced-intensity allogeneic hematopoietic stem cell transplantation for refractory or relapsed follicular lymphoma. (22674621)
2012
14
Imaging follicular lymphoma using positron emission tomography with [(18)F]fluorodeoxyglucose: to what purpose? (23109690)
2012
15
Is autologous stem cell transplantation for transformed follicular lymphoma still justifiable? (22239667)
2012
16
Long-term outcome after autologous or allogeneic stem cell transplantation in patients with recurrent follicular lymphoma. (22327132)
2012
17
Has the time to come leave the "watch-and-wait" strategy in newly diagnosed asymptomatic follicular lymphoma patients? (22650448)
2012
18
Severe CMV reactivation and gastritis during treatment of follicular lymphoma with bendamustine. (21811782)
2012
19
Is there a role for "watch and wait" in follicular lymphoma in the rituximab era? (23233615)
2012
20
In situ follicular lymphoma with progressive transformation of the germinal centers confirmed by laser capture microdissection, IGH gene rearrangement analysis, and fluorescence in situ hybridization for t(14;18). (21733560)
2012
21
Precision of histological bone marrow staging in follicular lymphoma and diffuse large B-cell lymphoma. (23217561)
2012
22
Clinical significance of the WHO grades of follicular lymphoma in a population-based cohort of 505 patients with long follow-up times. (22126847)
2012
23
High frequency of t(14;18) in Hodgkin's lymphoma associated with follicular lymphoma. (22827759)
2012
24
High-dose therapy with autologous stem cell transplantation versus chemotherapy or immuno-chemotherapy for follicular lymphoma in adults. (22258971)
2012
25
Prognostic factors in follicular lymphoma in the rituximab era: how to identify a high-risk patient? (21804618)
2011
26
Preferences of patients and physicians concerning treatment options for relapsed follicular lymphoma: a discrete choice experiment. (20935681)
2011
27
BIOMED-2 PCR assays for IGK gene rearrangements are essential for B-cell clonality analysis in follicular lymphoma. (21790530)
2011
28
An unusual presentation of follicular lymphoma. (20952121)
2011
29
Biology and treatment of follicular lymphoma. (21083019)
2009
30
Value of loss of CD10 expression in pathologic diagnosis of follicular lymphoma]. (20079015)
2009
31
PKC zeta mTOR pathway: a new target for rituximab therapy in follicular lymphoma. (17855629)
2008
32
Transient acantholytic dermatosis associated with B symptoms of follicular lymphoma. (17868396)
2007
33
Proteome- and microarray-based expression analysis of lymphoma cell lines identifies a p53-centered cluster of differentially expressed proteins in mantle cell and follicular lymphoma. (17990259)
2007
34
Human follicular lymphoma cells contain oligomannose glycans in the antigen-binding site of the B-cell receptor. (17197448)
2007
35
Variation in DNA repair genes ERCC2, XRCC1, and XRCC3 and risk of follicular lymphoma. (16492913)
2006
36
Primary mediastinal B-cell lymphoma: hypermutation of the BCL6 gene targets motifs different from those in diffuse large B-cell and follicular lymphomas. (15377470)
2004
37
Detection of BCL2-IGH rearrangement on paraffin-embedded tissue sections obtained from a small submucosal tumor of the rectum in a patient with recurrent follicular lymphoma. (15300917)
2004
38
Similarities of prosurvival signals in Bcl-2-positive and Bcl-2-negative follicular lymphomas identified by reverse phase protein microarray. (14767488)
2004
39
Genetic and molecular genetic studies in the diagnosis of B-cell lymphomas I: mantle cell lymphoma, follicular lymphoma, and Burkitt's lymphoma. (12733111)
2003
40
In situ localization of follicular lymphoma: description and analysis by laser capture microdissection. (11964306)
2002
41
Insights into the molecular pathogenesis of follicular lymphoma arising from analysis of geographic variation. (12036852)
2002
42
Variable heavy-chain gene analysis of follicular lymphomas: subclone selection rather than clonal evolution over time. (11418487)
2001
43
Association of a duodenal follicular lymphoma and hereditary nonpolyposis colorectal cancer. (10824932)
2000
44
Somatic mutations of the translocated bcl-2 gene are associated with morphologic transformation of follicular lymphoma to diffuse large-cell lymphoma. (9209654)
1997
45
Detection of the t(14;18) chromosomal translocation by interphase cytogenetics with yeast-artificial-chromosome probes in follicular lymphoma and nonneoplastic lymphoproliferation. (8622046)
1996
46
A human follicular lymphoma B cell line hypermutates its functional immunoglobulin genes in vitro. (8566010)
1995
47
MYC rearrangements in histologically progressed follicular lymphomas. (1638027)
1992
48
CD30 expression in follicular lymphoma. (1849500)
1991
49
Activation of the c-myc oncogene in a precursor-B-cell blast crisis of follicular lymphoma, presenting as composite lymphoma. (3285208)
1988
50
Radioimmunotherapy in follicular lymphoma: some like it hota8 (21334979)
.

Variations for Follicular Lymphoma

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Expression for genes affiliated with Follicular Lymphoma

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Search GEO for disease gene expression data for Follicular Lymphoma.

Pathways for genes affiliated with Follicular Lymphoma

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Pathways related to Follicular Lymphoma according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0BCL2, BCL6, IGHM
2
Show member pathways
Immune response BCR pathway58
Fc-epsilon receptor I signaling in mast cells36
10.0BCL6, IGHM, IGH
3
Show member pathways
Immune response T cell receptor signaling pathway58
Immune response CD28 signaling58
Immune response ICOS pathway in T helper cell58
10.0IGH, IGHM, HLA-DRB1
4
Show member pathways
9.6CD70, BCL2, TNFRSF17, TNFRSF14

Compounds for genes affiliated with Follicular Lymphoma

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GO Terms for genes affiliated with Follicular Lymphoma

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Cellular components related to Follicular Lymphoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:00058868.4CD70, GCSAM, P2RY8, C6orf25, TNFRSF17, TNFRSF14

Biological processes related to Follicular Lymphoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of B cell proliferationGO:003089010.2BCL2, BCL6
2negative regulation of G1/S transition of mitotic cell cycleGO:0200013410.2BCL2, ZC3H12D
3negative regulation of cell growthGO:003030810.1ZC3H12D, BCL2, BCL6
4defense response to Gram-negative bacteriumGO:005082910.0TNFRSF14, IGHM
5immune responseGO:00069559.8CD70, TNFRSF14, HLA-DRB1, IGKV1-5
6tumor necrosis factor-mediated signaling pathwayGO:00332099.7TNFRSF17, TNFRSF14

Molecular functions related to Follicular Lymphoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1tumor necrosis factor-activated receptor activityGO:000503110.0TNFRSF17, TNFRSF14

Products for genes affiliated with Follicular Lymphoma

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  • Antibodies
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  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Follicular Lymphoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet