MCID: FLL037
MIFTS: 47

Follicular Lymphoma malady

Cancer, Immune categories

Summaries for Follicular Lymphoma

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Follicular lymphoma is the most common of the indolent non-Hodgkin\'s lymphomas, and the... more...

MalaCards: Follicular Lymphoma, also known as lymphoma, follicular, is related to lymphoma, diffuse large cell and mantle cell lymphoma. An important gene associated with Follicular Lymphoma is BCL2 (B-cell CLL/lymphoma 2), and among its related pathways are PEDF Induced Signaling and TNF Signaling. The drug ibritumomab tiuxetan and the compounds bcma and rituximab have been mentioned in the context of this disorder. Affiliated tissues include skin, lymph node and lung, and related mouse phenotype immune system.

Aliases & Classifications for Follicular Lymphoma

Sources:
43NIH Rare Diseases, 31LifeMap Discovery™, 61UMLS, 45Novoseek, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Immune


Aliases & Descriptions:

follicular lymphoma 43 31
lymphoma, follicular 43 61
lymphoma follicular 45


External Ids:

ICD1025 C82

Related Diseases for Follicular Lymphoma

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Follicular Lymphoma family:

follicular lymphoma 1

Diseases related to Follicular Lymphoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 96)
idRelated DiseaseScoreTop Affiliating Genes
1lymphoma, diffuse large cell31.1KRBOX4, BCL6, BCL2
2mantle cell lymphoma30.5BCL2, BCL6
3b-cell lymphomas30.4IGHM, AICDA, BCL6, BCL2
4burkitt's lymphoma30.3IGHM, AICDA, CD27, BCL6, BCL2
5central nervous system lymphoma30.3BCL6
6gastric lymphoma30.3BCL6
7central nervous system lymphoma, primary30.0BCL6, IGHM
8gastrointestinal lymphoma10.6
9bone lymphoma10.5
10lymphoma, follicular, somatic10.5
11colon lymphoma10.5
12lymphoma, somatic10.5
13diffuse large b-cell lymphoma10.5
14hematopoietic stem cell transplantation10.5
15pediatric lymphoma10.4
16follicular lymphoma 110.4
17adult lymphoma10.4
18lymphoblastic lymphoma10.4
19histiocytic sarcoma10.3
20pemphigus10.3
21progressive multifocal leukoencephalopathy10.3
22composite lymphoma10.3
23paraneoplastic pemphigus10.3
24follicular dendritic cell sarcoma10.2
25breast lymphoma10.2
26richter's syndrome10.1
27rectum lymphoma10.1
28thyroid lymphoma10.1
29protein-losing enteropathy10.1
30follicular mucinosis10.1
31retroperitoneal lymphoma10.1
32acute leukemia10.1
33t-cell leukemia10.1
34transient acantholytic dermatosis10.1
35lymphoma, small cleaved-cell, follicular10.1
36peripheral t-cell lymphoma10.1
37splenomegaly10.1
38leukemia/lymphoma, t-cell10.1
39chronic lymphocytic leukemia10.0TNFRSF17, IGHM, AICDA, CD70, CD27, IL3RA
40non-hodgkin lymphoma10.0TNFRSF17, AICDA, CD70, CD27, FCGR3A, KRBOX4
41crohn's disease10.0
42neuromyelitis optica10.0
43juvenile xanthogranuloma10.0
44q fever10.0
45wiskott-aldrich syndrome10.0
46prothrombin deficiency10.0
47cicatricial pemphigoid10.0
48adult xanthogranuloma10.0
49alpha chain disease10.0
50ovarian lymphoma10.0

Graphical network of the top 20 diseases related to Follicular Lymphoma:



Diseases related to follicular lymphoma

Clinical Features for Follicular Lymphoma

Drugs & Therapeutics for Follicular Lymphoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Follicular Lymphoma

Drug clinical trials:

Search ClinicalTrials for Follicular Lymphoma

Search NIH Clinical Center for Follicular Lymphoma

Search CenterWatch for Follicular Lymphoma

Inferred drug relations via UMLS61/NDF-RT41:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Follicular Lymphoma cell therapies at LifeMap Discovery.

Genetic Tests for Follicular Lymphoma

Anatomical Context for Follicular Lymphoma

Sources:
33MalaCards
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MalaCards organs/tissues related to Follicular Lymphoma:

33
Skin, Lymph node, Lung, Spleen, Bone marrow, Whole blood, Small intestine, Colon, Thyroid, Breast, Prostate, Testis, Monocytes, Nk cells, T cells, B lymphoblasts, B cells, Endothelial

Animal Models for Follicular Lymphoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Follicular Lymphoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538710.9BCL2, BCL6, FCGR3A, CD27, CD70, AICDA

Publications for Follicular Lymphoma

Sources:
51PubMed
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Articles related to Follicular Lymphoma:

(show top 50)    (show all 948)
idTitleAuthorsYear
1
Phase I study of a modified regimen of a8^a8^Yttrium-ibritumomab tiuxetan for relapsed or refractory follicular or transformed CD20+ non-Hodgkin lymphoma. (23530878)
2013
2
Follicular lymphoma in Taiwan: a low frequency of t(14;18), with grade 3A tumours more closely related to grade 3B than to low-grade tumours. (23631722)
2013
3
Is there a role for autotransplants in patients with follicular lymphoma in the rituximab era? (23850133)
2013
4
David versus Goliath: decision analysis predicts results of a large clinical trial in follicular lymphoma. (23980082)
2013
5
Clinical implications and prognostic role of minimal residual disease detection in follicular lymphoma. (23730496)
2013
6
Prognostic significance of epigenetic inactivation of p16, p15, MGMT and DAPK genes in follicular lymphoma. (23275143)
2013
7
Somatic hypermutation analysis in follicular lymphoma provides evidence suggesting bidirectional cell migration between lymph node and bone marrow during disease progression and relapse. (23585531)
2013
8
Usefulness of positron emission tomography in primary intestinal follicular lymphoma. (23569346)
2013
9
Rates and outcomes of follicular lymphoma transformation in the immunochemotherapy era: a report from the University of Iowa/MayoClinic Specialized Program of Research Excellence Molecular Epidemiology Resource. (23897955)
2013
10
Long-term outcome after autologous or allogeneic stem cell transplantation in patients with recurrent follicular lymphoma. (22327132)
2012
11
In situ follicular lymphoma with progressive transformation of the germinal centers confirmed by laser capture microdissection, IGH gene rearrangement analysis, and fluorescence in situ hybridization for t(14;18). (21733560)
2012
12
High frequency of t(14;18) in Hodgkin's lymphoma associated with follicular lymphoma. (22827759)
2012
13
FDG PET/CT predictive role in follicular lymphoma. (22354449)
2012
14
An Efficient Computational Framework for the Analysis of Whole Slide Images: Application to Follicular Lymphoma Immunohistochemistry. (22962572)
2012
15
Severe anemia during rituximab maintenance therapy for follicular lymphoma. (22231048)
2012
16
Errors in Byline and Text in: Primary Cutaneous Follicular Helper T-cell Lymphoma: A New Subtype of Cutaneous T-cell Lymphoma Reported in a Series of 5 Cases. (23752735)
2012
17
Follicular lymphoma: to treat or not to treat is no longer the question. (22190632)
2012
18
Maintenance rituximab in follicular non-Hodgkin lymphoma: facts and controversies. (21958083)
2012
19
A meta-analysis of genome-wide association studies of follicular lymphoma. (23025665)
2012
20
Racial differences in presentation and management of follicular non-Hodgkin lymphoma in the United States: report from the National LymphoCare Study. (22434428)
2012
21
Rituximab in combination with multiagent chemotherapy for pediatric follicular lymphoma. (21462303)
2011
22
Relationship between deoxycytidine kinase (DCK) genotypic variants and fludarabine toxicity in patients with follicular lymphoma. (21030078)
2011
23
YY1 expression predicts favourable outcome in follicular lymphoma. (21109702)
2011
24
Immunotherapy for patients with follicular lymphoma: the contribution of systematic reviews. (21150184)
2011
25
The role of in vivo T-cell depletion on reduced-intensity conditioning allogeneic stem cell transplantation from HLA-identical siblings in patients with follicular lymphoma. (21183951)
2011
26
Rituximab maintenance in follicular lymphoma: PRIMA. (21176951)
2011
27
Early steps of follicular lymphoma pathogenesis. (21970951)
2011
28
Rituximab-induced immunodysregulatory ileocolitis in a patient with follicular lymphoma. (21098319)
2011
29
Classification of follicular lymphoma images: a holistic approach with symbol-based machine learning methods. (22138763)
2011
30
Severe paraneoplastic pemphigus in a patient with follicular lymphoma. (19845742)
2010
31
Diagnostic and prognostic impact of 18F-FDG PET/CT in follicular lymphoma. (20717826)
2010
32
Treatment strategies for nodal and gastrointestinal follicular lymphoma: current status and future development. (21105187)
2010
33
Vascularization predicts overall survival and risk of transformation in follicular lymphoma. (20713461)
2010
34
Prognostic significance of B-cell differentiation genes encoding proteins in diffuse large B-cell lymphoma and follicular lymphoma grade 3. (18925696)
2008
35
IL-4 protein expression and basal activation of Erk in vivo in follicular lymphoma. (18682601)
2008
36
Acquired prothrombin deficiency in a patient with follicular lymphoma. (18355267)
2008
37
Potentiation of apoptosis by heat stress plus pesticide exposure in stress resistant human B-lymphoma cells and its attenuation through interaction with follicular dendritic cells: role for c-Jun N-terminal kinase signaling. (16237197)
2006
38
BCL2 gene abnormalities define distinct clinical subsets of follicular lymphoma. (16918969)
2006
39
Small follicular lymphoma arising near the ampulla of vater: a distinct subtype of duodenal lymphoma? (16648662)
2005
40
Insights into the molecular pathogenesis of follicular lymphoma arising from analysis of geographic variation. (12036852)
2002
41
CXCL13 (BCA-1) is produced by follicular lymphoma cells: role in the accumulation of malignant B cells. (12406091)
2002
42
Bcl-2 antisense oligonucleotides are effective against systemic but not central nervous system disease in severe combined immunodeficient mice bearing human t(14;18) follicular lymphoma. (11948143)
2002
43
MUC1 mucin expression in follicular dendritic cells and lymphoepithelial lesions of gastric mucosa-associated lymphoid tissue lymphoma. (12685546)
2002
44
Follicular mucinosis associated with early stage cutaneous T-cell lymphoma: successful treatment with interferon alpha-2b and acitretin. (12243671)
2001
45
Anti-CD20 monoclonal antibody (rituximab) for refractory erosive stomatitis secondary to CD20(+) follicular lymphoma-associated paraneoplastic pemphigus. (11255323)
2001
46
V(D)J recombinase-mediated transposition of the BCL2 gene to the IGH locus in follicular lymphoma. (10961899)
2000
47
Lymphomas with follicular and monocytoid B-cell components. Evidence for a common clonal origin from follicle center cells. (11026097)
2000
48
Bcl-6 and Bcl-2 protein expression in diffuse large B-cell lymphoma and follicular lymphoma: correlation with 3q27 and 18q21 chromosomal abnormalities. (10414499)
1999
49
p53 mutation is associated with progression in follicular lymphomas. (8400252)
1993
50
Follicular lymphomatoid papulosis. (7246982)
1980

Genetic Variations for Follicular Lymphoma

Expression for genes affiliated with Follicular Lymphoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Follicular Lymphoma

Search GEO for disease gene expression data for Follicular Lymphoma.

Pathways for genes affiliated with Follicular Lymphoma

Sources:
52QIAGEN, 30KEGG, 56SinoBiological, 53R&D Systems, 38NCBI BioSystems Database, 12EMD Millipore
See all sources

Compounds for genes affiliated with Follicular Lymphoma

Sources:
45Novoseek, 50PharmGKB, 11DrugBank
See all sources

Compounds related to Follicular Lymphoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1bcma4510.6CD27, TNFRSF17
2rituximab45 50 1112.3BCL2, BCL6, FCGR3A

GO Terms for genes affiliated with Follicular Lymphoma

Sources:
16Gene Ontology
See all sources

Biological processes related to Follicular Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of immune responseGO:05077610.6IGKV1-5, FCGR3A, BCL6
2extrinsic apoptotic signaling pathwayGO:09719110.6CD27, CD70
3negative regulation of cell growthGO:03030810.5ZC3H12D, BCL2, BCL6
4immune responseGO:00695510.4FCGR3A, IGHM, IGKV1-5, CD70

Products for genes affiliated with Follicular Lymphoma

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Follicular Lymphoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet