Follicular Lymphoma malady

Wikipedia: Follicular lymphoma is the most common of the indolent non-Hodgkin\'s lymphomas, and the...⁴⁴ more...

MalaCards: Follicular Lymphoma, also known as lymphoma, follicular, is related to non-hodgkin lymphoma and mantle cell lymphoma. An important gene associated with Follicular Lymphoma is KDSR (3-ketodihydrosphingosine reductase), and among its related pathways are Methotrexate Pathway (Cancer Cell), Pharmacodynamics and Pancreatic cancer. The drugs mitoxantrone and irinotecan hydrochloride and the compounds cyclophosphamide and ivig have been mentioned in the context of this disorder. Affiliated tissues include skin, lymph node and bone marrow, and related mouse phenotypes are craniofacial and liver/biliary system.

follicular lymphoma 30 lymphoma, follicular 30 33 43

lymphoma follicular 32 lymphoma 43

Disease types for follicular lymphoma family:

follicular lymphoma 1

Diseases related to follicular lymphoma by text searches and GeneDecks gene sharing:

(show top 50)    (show all 1050)

id	Related Disease	Score	Top Affiliating Genes
1	non-hodgkin lymphoma	38.4	ZNF673, NBN, MYC, RAG1, BIRC5, PAX5
2	mantle cell lymphoma	38.3	BCL2, BCL6, MDM2, CCND1, EZH2
3	peripheral t-cell lymphoma	36.0	PAX5, BCL6, MS4A1, CD5, IL2RA, MCL1
4	cutaneous t cell lymphoma	36.0	BIRC5, BAX, CDKN2B, CD5, IL15, IL2
5	malt lymphoma	34.8	MYC, BCL2, BCL6, CDKN2B, CDKN1B, CDKN2A
6	adult t-cell leukemia	34.5	MYC, PAX5, BCL2, BCL2L1, BCL6, BCR
7	gastric lymphoma	34.0	BCL2, BCL6, CDKN2A, FCER2, CCND3, IGH@
8	t-cell leukemia	34.0	LMO2, MYC, RAG1, BIRC5, BCL2, BCL2L1
9	multiple myeloma	33.8	BCL2L1, MCL1, CCND3, CCND1, TNFSF11
10	splenic marginal zone lymphoma	33.7	BTK, PAX5, BCL6, BCR, CDK6, CD5
11	marginal zone b-cell lymphoma	33.2	RB1, PAX5, BCL6, CDKN2A, IRF4, CCND1
12	intraocular lymphoma	32.5	BCL2, BCL6, IL10, IL4, SLC19A1
13	anaplastic large cell lymphoma	32.2	PIK3CA, RB1, MYC, BIRC5, PAX5, BCL2
14	acquired immunodeficiency syndrome	32.1	BCL6, MTR, B2M, CD40, CD55, CD38
15	central nervous system lymphoma, primary	31.8	PAX5, BCL6, MGMT, IGHM, CXCL13
16	immunodeficiency	31.8	PDCD1, BTK, BMP6, BCR, CD70, CD80
17	b-cell lymphomas	31.6	BTK, RB1, NBN, MYC, BIRC5, PAX5
18	b-cell non-hodgkin lymphoma	31.2	RB1, VEGFA, MYC, BIRC5, PAX5, KDSR
19	primary malignant lymphoma	31.2	PIK3CA, CDKN2B, CDKN2A, IGHM, TP53, DNTT
20	inflammatory myofibroblastic tumor	31.1	CDK4, MKI67, F13A1, CR1, CR2
21	breast cancer	31.1	PIK3CA, BRCA1, BRCA2, MYC, BMP6, CDK6
22	leukemia/lymphoma, t-cell	31.0	RB1, NBN, MYC, RAG1, BCL2, ZC3H12D
23	lymphosarcoma	31.0	BCL2, BCL6, IL10, IL2RA, MBL2, IGH@
24	acute lymphoblastic leukemia	31.0	BTK, RB1, NBN, LMO2, RAG1, PAX5
25	centrocytic lymphoma	31.0	BCL2, MKI67, CCND1
26	lymphoplasmacytoid lymphoma	31.0	PAX5, CD5, IGH@
27	gastrointestinal lymphoma	31.0	NBN, BCL2, CCND1, CASP8, TP53
28	thyroid lymphoma	31.0	BCL2, CDKN2B, CDKN2A, CCNA2, TP53, TNF
29	hairy cell leukemia	30.8	BCL6, CD80, CD5, CD40, IL2, IL2RA
30	primary effusion lymphoma	30.8	PIK3CA, VEGFA, MYC, BIRC5, PAX5, BCL2
31	reticulosarcoma	30.8	PAX5, BCL2, BCL6, B2M, CDKN1B, CCND3
32	kaposi's sarcoma	30.7	VEGFA, CDK6, IFNA1, IFNA2, F13A1, CASP8
33	lymphoblastic lymphoma	30.5	LMO2, RAG1, PAX5, BCL6, MS4A1, CDKN2B
34	lymphoma, diffuse large cell	30.3	ZNF673, MYC, PAX5, BCL2, BCL2L1, BCL6
35	richter's syndrome	30.2	BCR, CDKN2A, CD5, CD38, IRF4, IGH@
36	hypercalcemia	30.1	BMP6, B2M, IRF4, IL2, CCND1, TNF
37	hodgkin's lymphoma	30.0	BRCA1, BRCA2, RAG1, PAX5, BCL2, BCL2L1
38	leukemia/lymphoma	30.0	PIK3CA, PDCD1, RB1, NBN, VEGFA, MYC
39	panniculitis	29.9	BAX, IL2RA, CASP3, TNF, TNFRSF8, CSF3
40	burkitt's lymphoma	29.9	MYC, BMP6, RAG1, BIRC5, PAX5, BCL2
41	central nervous system lymphoma	29.8	RB1, VEGFA, MYC, BIRC5, PAX5, BCL2
42	systemic lupus erythematosus	29.2	PDCD1, FOXP3, FCGR2B, MBL2, CR2
43	mycosis fungoides	29.1	PDCD1, BCL2, CDKN2B, CDKN2A, MMP9, MLH1
44	hepatitis c	29.0	BCL6, IL10, IL12B, IL2, IL4, IFNA1
45	nijmegen breakage syndrome	28.8	NBN, BRCA1, LIG4, IL2, MDM2, AICDA
46	cryoglobulinemia	28.6	BMP6, BCL2, BCR, CD27, CD5, IL10
47	myelodysplastic syndrome	28.5	BIRC5, CDKN2B, CDKN1C, CD55, TNFSF10, CR1
48	lymphoproliferative syndrome	28.4	BCL2, CD27, CD5, IL10, IL2, IL2RA
49	sezary's disease	28.3	IL15, IL2, IL2RA, IL4, IL5, IFNA1
50	autoimmune lymphoproliferative syndrome	28.3	IL10, IL2RA, CASP8, TNFSF10

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 asparaginase, cytarabine, cytarabine liposome, doxorubicin hydrochloride, ibritumomab tiuxetan, irinotecan, irinotecan hydrochloride, mitoxantrone, mitoxantrone hydrochloride, thiotepa

MalaCards organs/tissues related to follicular lymphoma:

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MGI Mouse Phenotypes related to follicular lymphoma:

²⁵ (show all 27)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	craniofacial phenotype	MP:0005382	10.1	NBN, RAD23B, LIG4, XRCC2, XRCC4, MSC
2	liver/biliary system phenotype	MP:0005370	10.0	VEGFA, LMO2, RAG1, LIG4, BHMT, BCL6
3	respiratory system phenotype	MP:0005388	9.9	BRCA1, RAG1, BCL6, FOXP1, FCGR2B, IL12B
4	renal/urinary system phenotype	MP:0005367	9.7	PDCD1, BRCA1, LMO2, RAG1, BHMT, BCL2
5	endocrine/exocrine gland phenotype	MP:0005379	9.5	NBN, BRCA1, BRCA2, RAD23B, XRCC4, CDK6
6	pigmentation phenotype	MP:0001186	9.2	RB1, BRCA1, MYC, RAG1, BCL2, BCL2L11
7	hematopoietic system phenotype	MP:0005397	8.9	PDCD1, BTK, NBN, BRCA1, BRCA2, LMO2
8	no phenotypic analysis	MP:0003012	8.7	RB1, VEGFA, MYC, MTHFR, CDKN1B, CD5
9	embryogenesis phenotype	MP:0005380	8.4	PIK3CA, NBN, BRCA1, BRCA2, LMO2, MYC
10	nervous system phenotype	MP:0003631	8.3	PDCD1, RB1, NBN, BRCA1, LMO2, MYC
11	normal phenotype	MP:0002873	8.0	BRCA1, BRCA2, VEGFA, MYC, RAG1, RAD23B
12	integument phenotype	MP:0010771	7.9	BTK, RB1, BRCA1, BRCA2, LMO2, MYC
13	adipose tissue phenotype	MP:0005375	7.8	PIK3CA, RB1, BRCA1, MYC, RAD23B, BCL2
14	behavior/neurological phenotype	MP:0005386	7.7	PIK3CA, RB1, NBN, BRCA2, RAG1, RAD23B
15	limbs/digits/tail phenotype	MP:0005371	7.5	BTK, RB1, BRCA1, BRCA2, VEGFA, BCL2L11
16	digestive/alimentary phenotype	MP:0005381	7.3	BTK, RB1, BRCA1, BRCA2, VEGFA, MYC
17	immune system phenotype	MP:0005387	7.3	GCSAM, BTK, NBN, BRCA1, BRCA2, LMO2
18	skeleton phenotype	MP:0005390	6.7	RB1, BRCA1, BRCA2, VEGFA, MYC, BMP6
19	reproductive system phenotype	MP:0005389	6.5	PIK3CA, NBN, BRCA1, BRCA2, VEGFA, RAD23B
20	mortality/aging	MP:0010768	6.4	PIK3CA, PDCD1, BTK, RB1, BRCA1, BRCA2
21	growth/size phenotype	MP:0005378	6.0	PIK3CA, BTK, RB1, NBN, BRCA1, BRCA2
22	vision/eye phenotype	MP:0005391	5.5	PIK3CA, PDCD1, RB1, VEGFA, RAG1, RAD23B
23	tumorigenesis	MP:0002006	5.4	PIK3CA, BTK, RB1, NBN, BRCA1, BRCA2
24	muscle phenotype	MP:0005369	5.1	PIK3CA, PDCD1, RB1, BRCA1, VEGFA, BNIP3
25	cardiovascular system phenotype	MP:0005385	4.5	PIK3CA, PDCD1, RB1, BRCA1, VEGFA, LMO2
26	homeostasis/metabolism phenotype	MP:0005376	4.4	PIK3CA, BTK, RB1, BRCA1, BRCA2, VEGFA
27	cellular phenotype	MP:0005384	2.6	PIK3CA, PDCD1, BTK, RB1, NBN, BRCA1

Articles related to follicular lymphoma:

(show top 50)    (show all 223)

id	Title	Authors	Year	Affiliating Genes
1	The architectural pattern of FOXP3-positive T cells i n follicular lymphoma is an independent predictor of survival and histologic tr ansformation. (19901260)	Farinha P.... Gascoyne R.D.	2010	TCF3
2	Lysosomal-mitochondrial axis in zoledronic acid-induc ed apoptosis in human follicular lymphoma cells. (19875454)	Mitrofan L.M.... MAPnkkAPnen J.	2010	CASP3, CASP9, FDPS
3	Transformation from follicular lymphoma to high-grade B-cell lymphoma/leukemia with additional t(2;8)(p12;q24), with inverse expressions of c-MYC and BCL-2, and light-chain switch. (19351371)	Mannouji K.... Sadahira Y.	2009	MYC, BCL2
4	PDTC enables type I TRAIL signaling in type II follicular lymphoma cells. (18977530)	Nuutinen U.... Pelkonen J.	2009	TNFSF10
5	Influence of MBL-2 mutations in the infection risk of patients with follicular lymphoma treated with rituximab, fludarabine, and cyc lophosphamide. (19557622)	MartA-nez-LA^pez J.... TomA!s J.F.	2009	MBL2
6	BCL2 protein expression in follicular lymphomas with t(14;18) chromosomal translocations. (19120369)	Masir N.... Lee A.M.	2009	BCL2
7	Clinical relevance of MDM2 SNP 309 and TP53 Arg72Pro in follicular lymphoma. (19029147)	Wrench D.... Fitzgibbon J.	2009	MDM2, TP53
8	The prevention of spontaneous apoptosis of follicular lymphoma B cells by a follicular dendritic cell line: involvement of caspase-3, caspase-8 and c-FLIP. (18556415)	Goval J.J.... de Leval L.	2008	CASP8
9	S(mu) mutation patterns suggest different progression pathways in follicular lymphoma: early direct or late from FL progenitor cells. (18515657)	Ruminy P.... Bastard C.	2008	IGHM
10	Expression of the follicular lymphoma variant translocation 1 gene in diffuse large B-cell lymphoma correlates with subtype and clinical outcome. (19019774)	Czuchlewski D.R.... Cesarman E.	2008	KDSR
11	CD40 ligand protects from TRAIL-induced apoptosis in follicular lymphomas through NF-kappaB activation and up-regulation of c-FLIP and Bcl-xL. (18606651)	Travert M.... Guillaudeux T.	2008	BCL2L1, CD40
12	Proteome- and microarray-based expression analysis of lymphoma cell lines identifies a p53-centered cluster of differentially expressed proteins in mantle cell and follicular lymphoma. (17990259)	Weinkauf M.... Dreyling M.	2007	TP53
13	Bcl2-negative follicular lymphomas frequently have Bcl6 translocation and/or Bcl6 or p53 expression. (17295647)	Guo Y.... Ohshima K.	2007	BCL6
14	Detection of t (14; 18) chromosomal translocation in paraffin-embedded tissues of follicular lymphoma and its clinical significance (18070448)	Zhang P.H.... Zhu X.Z.	2007	IGH@
15	MUM1 expression dichotomises follicular lymphoma into predominantly, MUM1-negative low-grade and MUM1-positive high-grade subtypes. (17296585)	Naresh K.N.	2007	MME, BCL6, IRF4
16	Differential gene expression in non-malignant tumour microenvironment is associated with outcome in follicular lymphoma patients treated with rituximab and CHOP. (16925574)	Harjunpaa A.... Leppa S.	2006	SMAD1, BMP6, MARCO
17	High numbers of tumor-infiltrating FOXP3-positive regulatory T cells are associated with improved overall survival in follicular lymphoma. (16825494)	Carreras J.... Banham A.H.	2006	FOXP3
18	Molecular, cytogenetic, and immunophenotypic characterization of follicular lymphoma grade 3B; a separate entity or part of the spectrum of diffuse large B-cell lymphoma or follicular lymphoma? (16647949)	Bosga-Bouwer A.G.... Poppema S.	2006	BCL6
19	Implication of the folate-methionine metabolism pathways in susceptibility to follicular lymphomas. (16410450)	Niclot S.... Baudry-Bluteau D.	2006	TYMS, MTR, MTHFR
20	Improvement of overall and failure-free survival in s tage IV follicular lymphoma: 25 years of treatment experience at The University of Texas M.D. Anderson Cancer Center. (16575009)	Liu Q.... McLaughlin P.	2006	IFNA1
21	Transformation of follicular lymphoma to Burkitt-like lymphoma within a single lymph node. (15948125)	Mukhopadhyay S.... Sidhu J.S.	2005	MYC, BCL2
22	Expression of human 8-oxoguanine DNA glycosylase (hOGG1) in follicular lymphoma. (16056251)	Sheehan A.M.... Chang C.C.	2005	OGG1
23	Complex diagnosis of follicular lymphomas. (16249809)	Toth E.... Szentirmay Z.	2005	BCL2, MS4A1, CD5
24	Lack of Bcl-2 expression in follicular lymphoma may be caused by mutations in the BCL2 gene or by absence of the t(14;18) translocation. (15682435)	Schraders M.... van Krieken H.	2005	BCL2
25	Interferon alpha 2b as maintenance therapy improves outcome in follicular lymphoma. (15512813)	Aviles A.... Sotelo L.	2004	IFNA2
26	Prognostic significance of bcl-xL gene expression and apoptotic cell counts in follicular lymphoma. (12969962)	Zhao W.L.... Janin A.	2004	BCL2L1
27	Activation-induced cytidine deaminase expression in follicular lymphoma: association between AID expression and ongoing mutation in FL. (14990977)	Hardianti M.S.... Yasuda N.	2004	AICDA
28	Translocation (16;18)(p13;q21.3) in follicular lymphoma. (15474153)	Mahmoodi M.... Hou J.S.	2004	TNFRSF17
29	Quantitative proteomic and transcriptional analysis of the response to the p38 mitogen-activated protein kinase inhibitor SB203580 in transformed follicular lymphoma cells. (15169874)	Lin Z.... Elenitoba-Johnson K.S.	2004	MAPK14
30	Follicular lymphoma of the skin and superficial soft tissues associated with a prominent follicular dendritic cell proliferation: an unusual pattern which may represent a diagnostic pitfall. (15462504)	Kazakov D.V.... Michal M.	2004	F13A1
31	bcl-2 expression by multicolor flow cytometric analysis assists in the diagnosis of follicular lymphoma in lymph node and bone marrow. (12520710)	Cook J.R.... Swerdlow S.H.	2003	BCL2
32	RANKL expression in a case of follicular lymphoma. (12756027)	Barcala V.... Mongini C.	2003	TNFSF11
33	CD5+ follicular lymphoma: a clinicopathologic study of three cases. (12375647)	Barry T.S.... Pittaluga S.	2002	CD5
34	Establishment and comprehensive analysis of a new human transformed follicular lymphoma B cell line, Tat-1. (11840295)	Denyssevych T.... Mayer L.D.	2002	IGH@
35	Rituximab in autologous stem cell transplantation for follicular lymphoma. (11508933)	Schmitz N.	2001	BCL2
36	The significance of molecular response of follicular lymphoma to central lymphatic irradiation as measured by polymerase chain reaction for t(14;18)(q32;q21). (11172955)	Ha C.S.... Cox J.D.	2001	B2M
37	Cyclin A down-regulation in TGFbeta1-arrested follicular lymphoma cells. (11082295)	Djaborkhel R.... MA1ller J.	2000	CDK4, CDK2, PLAU
38	Association of a duodenal follicular lymphoma and hereditary nonpolyposis colorectal cancer. (10824932)	Rosty C.... Laurent-Puig P.	2000	MLH1
39	Follicular lymphoma can be distinguished from benign follicular hyperplasia by flow cytometry using simultaneous staining of cytopla smic bcl-2 and cell surface CD20. (10941341)	Cornfield D.B.... Braylan R.C.	2000	BCL2
40	The synthesis of Bcl-2 and other proteins in the neop lastic follicles of follicular lymphoma. (10439836)	Lampert I.A.	1999	BCL2
41	Primary follicular lymphoma of the testis in childhood. (10193956)	Finn L.S.... Salhany K.E.	1999	BCL6
42	p53 mutation in a case of blastic transformation of follicular lymphoma with double bcl-2 rearrangement (MBR and VCR). (9643573)	NomdedAcu J.F.... Soler J.	1998	BCL2
43	CD10 expression in follicular lymphoma and large cell lymphoma is different from that of reactive lymph node follicles. (9625422)	Almasri N.M.... Braylan R.C.	1998	MME
44	Apoptotic induction in transformed follicular lymphoma cells by Bcl-2 downregulation. (9713967)	Tormo M.... Lopez-Berestein G.	1998	BCL2, BAX
45	Somatic mutations of the translocated bcl-2 gene are associated with morphologic transformation of follicular lymphoma to diffuse large-cell lymphoma. (9209654)	Matolcsy A.... Knowles D.M.	1997	BCL2
46	T-cell derived cytokines co-stimulate proliferation of CD40-activated germinal centre as well as follicular lymphoma cells. (9722891)	Schmitter D.... Pichert G.	1997	IL4
47	Histological progression of follicular lymphoma associated with p53 mutation and rearrangement of the C-MYC gene. (8810134)	Takimoto Y.... Nanba K.	1996	BCL2
48	Follicular lymphoma adjacent to foreign body granulom atous inflammation and fibrosis surrounding silicone breast prosthesis. (7755157)	Cook P.D.... Strauss J.F.	1995	BCL2
49	Cross-linking of surface IgG induces apoptosis in a b cl-2 expressing human follicular lymphoma line of mature B cell phenotype. (7696202)	Eray M.... Kaartinen M.	1994	BCL2
50	Mechanism of bcl-2 activation in human follicular lymphoma. (2181381)	Hua C.... Cossman J.	1990	BCL2

Genes related to follicular lymphoma according to GeneCards:

(show top 50)    (show all 165)

id	Symbol	Description	Score	GeneCards Section Context
1	KDSR	3-ketodihydrosphingosine reductase	11.1	Orthologs, Summaries, Aliases & Descriptions, Publications
2	FL1	Follicular lymphoma, susceptibility to, 1	11.1	Aliases & Descriptions
3	BCL2	B-cell CLL/lymphoma 2	11.1	Summaries, Publications
4	ZC3H12D	zinc finger CCCH-type containing 12D	11.1	Publications, Aliases & Descriptions
5	CLLS5	Leukemia, chronic lymphocytic susceptiblity to, 5	11.0	Publications
6	IGKV1-5	immunoglobulin kappa variable 1-5	11.0	Publications
7	C6orf15	chromosome 6 open reading frame 15	11.0	Publications
8	BCL6	B-cell CLL/lymphoma 6	11.0	Publications
9	IGHM	immunoglobulin heavy constant mu	11.0	Publications
10	P2RY8	purinergic receptor P2Y, G-protein coupled, 8	11.0	Publications
11	SSSCA1	Sjogren syndrome/scleroderma autoantigen 1	11.0	Publications
12	MSC	musculin	11.0	Publications
13	MTHFS	5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase)	11.0	Publications
14	GRHPR	glyoxylate reductase/hydroxypyruvate reductase	11.0	Publications
15	TNFRSF17	tumor necrosis factor receptor superfamily, member 17	11.0	Publications
16	IGH@	immunoglobulin heavy locus	11.0	Publications
17	CD70	CD70 molecule	11.0	Publications
18	MTHFD2	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase	11.0	Publications
19	CAMK1	calcium/calmodulin-dependent protein kinase I	11.0	Publications
20	SHMT1	serine hydroxymethyltransferase 1 (soluble)	11.0	Publications
21	TCN1	transcobalamin I (vitamin B12 binding protein, R binder family)	11.0	Publications
22	CD27	CD27 molecule	11.0	Publications
23	CD5	CD5 molecule	11.0	Publications
24	AICDA	activation-induced cytidine deaminase	11.0	Publications
25	FDPS	farnesyl diphosphate synthase	11.0	Publications
26	TNFRSF14	tumor necrosis factor receptor superfamily, member 14	11.0	Publications
27	TNFSF13	tumor necrosis factor (ligand) superfamily, member 13	11.0	Publications
28	C1QA	complement component 1, q subcomponent, A chain	11.0	Publications
29	C6orf25	chromosome 6 open reading frame 25	11.0	Publications
30	BHMT	betaine--homocysteine S-methyltransferase	11.0	Publications
31	IL21R	interleukin 21 receptor	11.0	Publications
32	IL3RA	interleukin 3 receptor, alpha (low affinity)	11.0	Publications
33	ERCC5	excision repair cross-complementing rodent repair deficiency, complementation group 5	11.0	Publications
34	RAG1	recombination activating gene 1	11.0	Publications
35	ENTPD1	ectonucleoside triphosphate diphosphohydrolase 1	11.0	Publications
36	MS4A1	membrane-spanning 4-domains, subfamily A, member 1	11.0	Publications
37	MARCO	macrophage receptor with collagenous structure	11.0	Publications
38	FCGR2B	Fc fragment of IgG, low affinity IIb, receptor (CD32)	11.0
39	LMO2	LIM domain only 2 (rhombotin-like 1)	11.0	Publications
40	GGH	gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)	11.0	Publications
41	IRF4	interferon regulatory factor 4	11.0	Publications
42	LIG4	ligase IV, DNA, ATP-dependent	11.0	Publications
43	FPGS	folylpolyglutamate synthase	11.0	Publications
44	ZNF673	zinc finger family member 673	11.0	Publications
45	BNIP3	BCL2/adenovirus E1B 19kDa interacting protein 3	11.0	Publications
46	XRCC2	X-ray repair complementing defective repair in Chinese hamster cells 2	11.0	Publications
47	CDKN1C	cyclin-dependent kinase inhibitor 1C (p57, Kip2)	11.0	Publications
48	TNFRSF13B	tumor necrosis factor receptor superfamily, member 13B	11.0	Publications
49	PDCD1	programmed cell death 1	11.0	Publications
50	FCER2	Fc fragment of IgE, low affinity II, receptor for (CD23)	11.0	Publications

Pathways related to follicular lymphoma according to GeneDecks:

(show top 50)    (show all 214)

id	Pathway	Score	Top Affiliating Genes
1	Methotrexate Pathway (Cancer Cell), Pharmacodynamics34	10.6	GGH, MTRR, MTHFR, MTR, MTHFS, CBS
2	Pancreatic cancer20	10.3	CDK6, BRCA2
3	RAR-Gamma-RXR-Alpha Degradation36	10.2	BTK, CD80, IL15, IL2, IL21, MAPK14
4	Immune response IL-22 signaling pathway10	10.1	MAPK14, STAT1, STAT5A, HLA-DQB1, MYC, BCL2
5	Immune response_IL-22 signaling pathway41	10.1	CD86, BCL2L1, BCL2, MAPK14, STAT5A, HLA-DQB1
6	NFAT Signaling and Lymphocyte Interactions36	9.9	TNFRSF17, BCL2, BAX, FCER2, BMP6, BTK
7	DNA Repair Mechanisms36	9.8	BRCA2, BRCA1, RAD23B, OGG1, TP53, ERCC4
8	TNF Superfamily Pathway36	9.6	MAPK14, CASP8, CASP9, TNF, TNFRSF14, CASP3
9	Apoptosis and survival Apoptotic TNF-family pathways10	9.6	TNF, CASP9, CASP8, CASP3, CD70, CD27
10	DNA Damage3	9.6	TP63, MSH2, MGMT, MDM2, APEX1, ERCC1
11	Apoptosis and survival_Apoptotic TNF-family pathways41	9.6	BCL2, TNFSF10, TNFRSF1B, TNF, CASP9, CASP8
12	Intestinal immune network for IgA production20	9.4	CD86, CD80, CD40, IL10, IL15, IL2
13	Small cell lung cancer20	9.4	SKP2, TP53, CCND1, CDK4, CDKN1B, CDKN2B
14	G1-S Phase Transition36	9.4	CDK2, TP53, CCND1, RB1, CDK6, CCND3
15	Signal transduction_AKT signaling41	9.4	TP53, EIF4EBP1, CDKN1B, MDM2, CCND3, CCND1
16	PGC1Alpha Pathway36	9.3	IL2, IL15, IL12B, CD80, BAX, BCL2
17	p53 signaling pathway20	9.3	CDK4, TP53, CDK6, CDK2, CDKN2A, MDM2
18	Cell cycle20	9.2	CDKN1C, RB1, MYC, CDK6, CDK2, CDKN2B
19	Hematopoietic cell lineage20	9.1	MS4A1, CD5, CSF3, CSF2, DNTT, CR2
20	Chronic myeloid leukemia20	9.0	RB1, MYC, BCL2L1, BCR, CDK6, CDKN2A
21	Measles20	8.9	TNFSF10, TLR9, STAT5A, STAT1, IFNA2, IFNA1
22	Endothelin-1 Signaling Pathway36	8.7	BTK, MYC, BMP6, IL10, IL12B, CD80
23	Allograft rejection20	8.7	HLA-DQB1, CD86, CD80, CD40, IL10, IL12B
24	Pancreatic Adenocarcinoma36	8.7	RB1, STAT5A, TP53, CCND1, CCNA2, MDM2
25	Autoimmune thyroid disease20	8.7	HLA-DQB1, IFNA1, CD40, IL10, IL5, CD86
26	Colorectal Cancer Metastasis36	8.6	CASP3, CCND1, MYC, BIRC5, BCL2L1, BAX
27	ERK Signaling36	8.6	EPHA7, CSF3, CXCL13, TNFSF13, STAT1, TNFSF11
28	Cell Cycle / Checkpoint Control3	8.5	RB1, NBN, BRCA1, BRCA2, XRCC1, MSH2
29	Akt Signaling36	8.5	IL12B, IL15, IL2, IL21, IL2RA, IL4
30	SOCS Pathway36	8.4	IL10, CD80, BAX, BCL2, BMP6, IL12B
31	IL-6 Pathway36	8.4	BAX, IL10, IL12B, IL4, IL5, IL8
32	Glucocorticoid Receptor Signaling36	8.2	BAX, BCL2, BMP6, BTK, STAT5A, TNFSF10
33	Tuberculosis20	8.1	CASP9, HLA-DQB1, TNF, CR1, TLR9, SYK
34	Cytokine Network36	8.1	IL4, IL10, IL5, IL8, IFNA1, IFNA2
35	Jak-STAT signaling pathway20	8.1	IL12B, IL15, IL2, IL21, IL21R, IL2RA
36	Molecular Mechanisms of Cancer36	8.0	CDK4, LTA, TCF3, CXCL13, SOX5, EPHA7
37	Tec Kinases Signaling36	7.9	IL2RA, IL3RA, IL4, IL5, IL8, TNF
38	TGF-Beta Pathway36	7.8	TNFRSF1B, TNFSF10, IL8, MAPK14, IL4, TNFRSF17
39	all-trans-Retinoic Acid Signaling in Brain36	7.7	TNF, TNFSF10, TNFSF11, TNFSF13, LTA, CXCL13
40	MIF Mediated Glucocorticoid Regulation36	7.7	CSF3, CSF2, CXCL13, LTA, TNFSF13, TNFSF11
41	JAK-STAT Pathway36	7.7	IL3RA, IL4, IL5, IL8, IFNA1, IFNA2
42	Antioxidant Action of Vitamin-C36	7.6	BTK, BMP6, BCL2, BAX, CD80, IL10
43	Pathways in cancer20	7.5	MSH2, CDK2, CDKN2B, CDKN1B, CDK4, MMP9
44	MIF Regulation of Innate Immune Cells36	7.5	IL12B, IL10, CD80, BAX, BCL2, BMP6
45	PEDF Induced Signaling36	7.5	IL4, IL5, IL8, CASP8, TNF, TNFSF10
46	STAT3 Pathway36	7.4	IL5, IL8, MAPK14, TNF, TNFRSF13B, TNFRSF14
47	PAK Pathway36	7.2	TNF, TNFSF10, TNFSF11, TNFSF13, LTA, CXCL13
48	p38 Signaling36	7.1	BTK, BMP6, BCL2, BAX, CD80, IL10
49	MAPK Family Pathway36	7.0	IL2, IL10, IL12B, CD80, BAX, BCL2
50	Cytokine-cytokine receptor interaction20	7.0	CSF3, CSF2, CXCL13, LTA, TNFSF13, TNFSF11

Compounds related to follicular lymphoma according to GeneDecks:

(show top 50)    (show all 449)

id	Compound	Score	Top Affiliating Genes
1	cyclophosphamide32 34 9 9	13.9	BCL6, MS4A1, MBL2, DCK
2	ivig32	10.8	BTK, FCGR2B, AICDA, LTA, CSF2
3	ionomycin32	10.5	BTK, RAG1, CDK6, CD70, CDK4, CD40
4	dmso32	10.4	BMP6, CR1, OGG1
5	vincristine32 34 9 9	13.4	BTK, BCL6, MGMT, IFNA1, SYK, DCK
6	threonine32	10.3	BTK, NBN, CDK6, CDKN2B, CDKN1B, IL3RA
7	roscovitine32	10.1	BIRC5, BCL2L1, MCL1, MAPK14, CCNA2, CASP8
8	h2o232	9.6	BRCA1, BRCA2, BCL2L11, BCR, CD40, MME
9	trastuzumab32 34 9 9	12.4	PIK3CA, BIRC5, CDK6, CDK2, CDKN1B, CDK4
10	dacarbazine32 9 9	11.4	BCL2, MLH1, MGMT, IL2, CCNA2, IFNA1
11	zinc32 18	10.3	ZNF673, RB1, BRCA2, LMO2, RAG1, BHMT
12	2-chlorodeoxyadenosine32	9.2	BIRC5, BCL2, BAX, B2M, IL2, IL2RA
13	folate32	9.2	BRCA1, BRCA2, MYC, BHMT, MTRR, MTHFR
14	rapamycin32 42	10.1	RB1, NBN, VEGFA, BCL2L11, MTOR, CDK6
15	mitomycin c32	9.0	RB1, NBN, BRCA1, BRCA2, BIRC5, XRCC2
16	p00232	8.9	RB1, BRCA1, BRCA2, BIRC5, MTHFR, XRCC1
17	indole-3-carbinol32	8.8	BRCA1, BRCA2, BIRC5, BCL2, BCL2L1, BAX
18	rituximab32 34 9 9	11.7	BIRC5, PAX5, BCL2, BCL2L1, BCL6, BCR
19	12-o-tetradecanoylphorbol 13-acetate32	8.7	RB1, MYC, BMP6, RAG1, BCL6, CDKN1B
20	celecoxib32 42 34 9 18 9	13.5	VEGFA, BIRC5, BCL2, BAX, CDK2, CDKN1B
21	n acetylcysteine32	8.5	BIRC5, XRCC3, CDKN1B, CDKN2A, CDK4, CD40
22	oxaliplatin32 34 9 9	11.4	BRCA1, VEGFA, BIRC5, BCL2L1, MTHFR, XRCC1
23	mg 13232 42	9.4	BRCA1, MYC, BIRC5, BCL2L1, BCL2L11, BAX
24	cysteine32	8.2	BTK, BRCA1, RAG1, BCL2L1, MTHFR, MTR
25	irinotecan32 34 9 9	11.2	VEGFA, BCL2L1, BAX, MTHFR, XRCC1, CDKN2A
26	progesterone32 42 9 18 9	12.2	PIK3CA, RB1, BRCA1, BRCA2, BIRC5, BCL2
27	camptothecin32 42 9 9	11.1	RB1, NBN, BRCA1, BRCA2, MYC, BIRC5
28	pdtc32	8.0	PIK3CA, BIRC5, BCL2, BCL2L1, CD40, MMP9
29	troglitazone32 42 9 9	11.0	RB1, BMP6, BIRC5, BCL2, BAX, CDK2
30	adpribose32	7.9	PIK3CA, RB1, BRCA1, BRCA2, BIRC5, BCL2
31	flavopiridol32 9 9	9.9	RB1, VEGFA, BIRC5, BCL2, BCL2L1, BAX
32	atp32	7.8	PIK3CA, BTK, RB1, BRCA1, BIRC5, BCL2L1
33	herbimycin a32 42	8.7	MYC, BMP6, CDK6, CDK2, CDK4, CD40
34	thalidomide32 42 9 9	10.7	VEGFA, BIRC5, BCL2L1, B2M, IL10, IL2
35	sb 20358032 42	8.7	BTK, RB1, VEGFA, BNIP3, BMP6, BIRC5
36	arsenite32 18	8.6	PIK3CA, VEGFA, MYC, BIRC5, BCL2, BCL2L1
37	docetaxel32 34 9 9	10.6	BRCA1, BRCA2, VEGFA, MYC, BIRC5, BCL2
38	neopterin32	7.5	B2M, CD40, CD38, FCER2, IL10, IL1RN
39	vegf32	7.3	PIK3CA, BRCA1, BNIP3, MYC, BCL2, BCL2L1
40	tamoxifen32 34 9 9	10.3	PIK3CA, BRCA1, BRCA2, VEGFA, MYC, BMP6
41	superoxide32 18	8.2	PIK3CA, RB1, BIRC5, MTR, CDK4, CD40
42	il 1032	7.1	BMP6, CD40, IL10, IL12B, IL15, IL1RN
43	ly29400232	6.7	PIK3CA, VEGFA, BCR, XPC, CDKN1B, MMP9
44	imatinib32 34 9 9	9.6	PIK3CA, VEGFA, MYC, BMP6, BIRC5, BCL2
45	phosphatidylinositol32	6.5	PIK3CA, BTK, RB1, NBN, BRCA2, BNIP3
46	pd 98,05932	6.4	PIK3CA, RB1, MYC, BMP6, BIRC5, BCL2
47	methotrexate32 34 42 9 9	9.9	RB1, BRCA1, BRCA2, BMP6, BIRC5, MTRR
48	paraffin32	5.4	RB1, BRCA1, BRCA2, VEGFA, MYC, BIRC5
49	thymidine32 18	6.1	PIK3CA, RB1, BRCA1, BRCA2, MYC, BMP6
50	tyrosine32	4.7	PIK3CA, PDCD1, BTK, RB1, BRCA1, BRD8

Cellular components related to follicular lymphoma according to GeneDecks:

(show all 14)

id	Name	GO ID	Score	Top Affiliating Genes
1	cyclin-dependent protein kinase holoenzyme complex	GO:000307	10.3	CDK4, CCND3, CCND1, CDK2, CDK6
2	Bcl-2 family protein complex	GO:097136	10.1	BAX, BCL2L1, MCL1
3	mitochondrial outer membrane	GO:005741	10.0	BCL2L11, CASP8, MCL1, MTOR, BAX, BNIP3
4	external side of plasma membrane	GO:009897	10.0	CD40, TNFRSF13B, TNFRSF14, CR2, TNF, B2M
5	protein complex	GO:043234	9.5	BRCA2, MYC, BHMT, CDKN2A, MMP9, FOXP3
6	integral to plasma membrane	GO:005887	9.4	IL15, FCER2, TNFRSF13B, CD55, CD40, CD5
7	nucleolus	GO:005730	8.8	BIRC5, BCL6, CASP3, CBS, APEX1, BRCA2
8	nucleoplasm	GO:005654	8.1	RB1, MCL1, APEX1, MDM2, MGMT, CDK4
9	cytosol	GO:005829	8.1	PIK3CA, MTR, MTHFS, XRCC4, CDK6, CDK2
10	plasma membrane	GO:005886	7.8	GCSAM, PDCD1, CD40, C6orf25, CD70, PLAU
11	cytoplasm	GO:005737	7.4	CDKN2B, CDK2, CDK6, XPC, IRF4, XRCC3
12	extracellular region	GO:005576	7.2	F2, HLA-C, IFNA2, TNFRSF1B, TNFSF10, TNFSF11
13	nucleus	GO:005634	6.6	CDK6, CDK2, CDKN2B, CDKN1B, CDKN2A, CDK4
14	extracellular space	GO:005615	5.8	VEGFA, IL8, IL5, IL4, IL21, IL2

Biological processes related to follicular lymphoma according to GeneDecks:

(show top 50)    (show all 92)

id	Name	GO ID	Score	Top Affiliating Genes
1	UV protection	GO:009650	10.8	MC1R, ERCC2, ERCC5, ERCC1, ERCC4
2	nucleotide-excision repair, DNA damage removal	GO:000718	10.8	ERCC4, RAD23B, ERCC5, XPC, ERCC1, ERCC2
3	T cell differentiation in thymus	GO:033077	10.8	TP53, B2M, XRCC4, BCL2, LIG4, STAT5A
4	negative regulation of survival gene product expression	GO:008634	10.6	BCL2L1, MYC, SKP2, BNIP3, BAX
5	B cell homeostasis	GO:001782	10.6	BCL2, BAX, TNFRSF13B, CASP3, BCL2L11
6	T cell homeostasis	GO:043029	10.6	FOXP3, BCL2, BCL2L11, STAT5A, CASP3
7	nucleotide-excision repair	GO:006289	10.5	ERCC2, BRCA2, OGG1, RAD23B, XPC, TP53
8	positive regulation of tissue remodeling	GO:034105	10.5	IL2, IL12B, IL21, IL15
9	isotype switching	GO:045190	10.5	ERCC1, MSH2, XRCC4, LIG4, NBN
10	response to gamma radiation	GO:010332	10.5	XRCC4, MYC, LIG4, BCL2, BAX, XRCC2
11	folic acid metabolic process	GO:046655	10.4	SLC19A1, SHMT1, FPGS, MTHFR
12	response to X-ray	GO:010165	10.4	ERCC1, CCND1, XRCC2, MSH2, XRCC4, LIG4
13	release of cytochrome c from mitochondria	GO:001836	10.4	MYC, BCL2, BCL2L1, BAX, CASP3, TP53
14	activation of pro-apoptotic gene products	GO:008633	10.3	TNFSF10, CASP8, BAX, BCL2L11, BCL2, MYC
15	positive regulation of B cell proliferation	GO:030890	10.3	IL5, BCL6, CD40, CD38, TCF3, BCL2
16	induction of apoptosis by intracellular signals	GO:008629	10.3	BCL2L1, BCL2L11, BAX, CASP8, BCL2, TP53
17	tumor necrosis factor-mediated signaling pathway	GO:033209	10.3	TNFRSF17, TNFSF11, TNF, TNFRSF14, TNFRSF8, STAT1
18	T cell costimulation	GO:031295	10.3	HLA-DQB1, MTOR, CD86, CD80, CD5, TNFRSF14
19	neuron apoptotic process	GO:051402	10.2	TP63, CASP3, TP53, BAX, BCL2, LIG4
20	positive regulation of inflammatory response	GO:050729	10.2	STAT5A, TLR9, IL21, IL2, IL15, IL12B
21	positive regulation of release of cytochrome c from mitochondria	GO:090200	10.2	TNFSF10, BNIP3, BCL2L11, BAX, TP53
22	response to DNA damage stimulus	GO:006974	10.2	BRCA1, MYC, BCL2, BCL6, WRN, TP53
23	double-strand break repair	GO:006302	10.2	TP53, LIG4, XRCC4, BRCA1, NBN, ERCC1
24	response to ethanol	GO:045471	10.1	BCL2, CD27, GGH, MMP9, MGMT, IL4
25	virus-host interaction	GO:019048	10.1	BAX, SYK, MDM2, HLA-C, ERCC2, CASP8
26	cell proliferation	GO:008283	10.1	IL2RA, SYK, SKP2, TNFRSF17, NBN, LIG4
27	innate immune response	GO:045087	9.9	CR1, C1QA, SYK, CR2, BCL2L1, BCL2
28	DNA repair	GO:006281	9.9	MSH2, XPC, XRCC4, XRCC3, XRCC2, XRCC1
29	G1 phase of mitotic cell cycle	GO:000080	9.9	CDKN1B, CDKN2A, SKP2, CDK4, CDK6, CCND1
30	positive regulation of neuron apoptotic process	GO:043525	9.8	BAX, CASP3, CASP9, TNF, BCL2L11, EPHA7
31	cytokine-mediated signaling pathway	GO:019221	9.8	IRF4, CSF3, HLA-DQB1, SOCS3, STAT5A, TNFSF11
32	induction of apoptosis by extracellular signals	GO:008624	9.7	CD5, BTK, BCL2L11, BAX, CD38, CASP3
33	B cell differentiation	GO:030183	9.7	IL4, AICDA, TCF3, IL10, MSH2, BCL6
34	G1/S transition of mitotic cell cycle	GO:000082	9.7	TYMS, CDK4, CDKN1B, CCND1, RB1, BCL2
35	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	9.5	TNFRSF14, VEGFA, MTOR, CD80, IL5, TP53
36	negative regulation of growth of symbiont in host	GO:044130	9.3	LTA, IL12B, IL10, MBL2, TNF
37	activation of cysteine-type endopeptidase activity involved in apoptotic process	GO:006919	9.2	TNFSF10, CDKN1B, CDKN2A, CASP8, TNF, BAX
38	cell cycle arrest	GO:007050	9.2	MYC, TP53, MSH2, CDKN1C, IL12B, IL8
39	induction of apoptosis	GO:006917	9.1	ERCC2, TNF, CASP3, IFNA2, CDKN2A, CDKN1B
40	immune response	GO:006955	9.0	CR2, TNFSF13, TNFSF11, TNFRSF14, IL21, IL2RA
41	response to molecule of bacterial origin	GO:002237	8.9	TLR9, IL8, IL10, B2M
42	anti-apoptosis	GO:006916	8.8	MCL1, IL2, SOCS3, IL10, CD27, TNF
43	apoptotic process	GO:006915	8.7	MAPK14, MCL1, IL2RA, MSH2, BAX, BCL2L11
44	positive regulation of cell proliferation	GO:008284	8.7	IL15, NBN, VEGFA, MYC, BIRC5, BCL2L1
45	negative regulation of apoptotic process	GO:043066	8.6	VEGFA, MDM2, CASP3, IL4, ERCC2, TNF
46	response to drug	GO:042493	8.4	IL1RN, IL4, CCND1, TNF, BCL2, SMAD1
47	negative regulation of transcription, DNA-dependent	GO:045892	8.0	CDKN1B, BCL6, CDKN2A, CDKN1C, CD38, FOXP1
48	positive regulation of transcription, DNA-dependent	GO:045893	7.8	BRCA1, CD38, IL4, RB1, BRCA2, MYC
49	inflammatory response	GO:006954	7.8	TLR9, SMAD1, TNFRSF1B, CAMK1D, IFNA2, IL8
50	positive regulation of transcription from RNA polymerase II promoter	GO:045944	7.7	TP53, VEGFA, BRCA1, TP63, TNF, TNFSF11

Molecular functions related to follicular lymphoma according to GeneDecks:

(show all 18)

id	Name	GO ID	Score	Top Affiliating Genes
1	damaged DNA binding	GO:003684	10.6	NBN, XRCC1, XPC, APEX1, ERCC4, ERCC1
2	tumor necrosis factor-activated receptor activity	GO:005031	10.6	TNFRSF17, TNFRSF14, TNFRSF1B, TNFRSF8
3	endonuclease activity	GO:004519	10.6	OGG1, APEX1, ZC3H12D, RAG1, ERCC5
4	BH3 domain binding	GO:051434	10.5	BAX, MCL1, BCL2, BCL2L1
5	bubble DNA binding	GO:000405	10.5	WRN, ERCC5, XPC
6	single-stranded DNA binding	GO:003697	10.3	RAD23B, ERCC4, ERCC1, ERCC5, MLH1, MSH2
7	ubiquitin protein ligase binding	GO:031625	10.1	TNFRSF14, TP53, BCL2, TNFRSF1B, RB1, CBS
8	cyclin-dependent protein kinase inhibitor activity	GO:004861	10.0	CDKN1B, CDKN2A, CDKN1C, CASP3, CDKN2B
9	tumor necrosis factor receptor binding	GO:005164	9.9	STAT1, LTA, TNFSF13, TNFSF11, TNF, CASP8
10	protein homodimerization activity	GO:042803	9.7	GRHPR, STAT1, VEGFA, TCF3, SHMT1, CR2
11	protein C-terminus binding	GO:008022	9.6	XRCC4, ERCC4, ERCC1, ERCC2, MAPK14, MKI67
12	identical protein binding	GO:042802	9.6	CASP8, BNIP3, BCL2, BCL2L1, BAX, BIRC5
13	enzyme binding	GO:019899	9.5	CD40, BRCA1, BIRC5, MSH2, CSF3, STAT1
14	protein kinase binding	GO:019901	9.5	CCNA2, CDKN2A, CDKN2B, SYK, TP53, MSH2
15	protein heterodimerization activity	GO:046982	9.3	IL12B, CXCL13, TCF3, TP53, MCL1, BCL2
16	growth factor activity	GO:008083	7.9	CSF3, F2, CSF2, IL5, IL4, IL2
17	cytokine activity	GO:005125	7.4	LTA, TNFSF10, TNF, IFNA2, IL5, IL4
18	protein binding	GO:005515	3.0	IL4, CDK4, RB1, NBN, BRCA1, BRCA2