FTC
MCID: FLL032
MIFTS: 63

Follicular Thyroid Carcinoma (FTC) malady

Rare diseases, Endocrine diseases, Cancer diseases categories
Download this MalaCard

Summaries for Follicular Thyroid Carcinoma

About this section
Sources:
65Wikipedia, 47OMIM, 33MalaCards
See all sources

Fully expand this MalaCard
Wikipedia:65 Follicular thyroid cancer accounts for 15% of thyroid cancer and occurs more commonly in women over 50... more...

MalaCards: Follicular Thyroid Carcinoma, also known as thyroid carcinoma, follicular, is related to goiter and adenoma. An important gene associated with Follicular Thyroid Carcinoma is MINPP1 (multiple inositol-polyphosphate phosphatase 1), and among its related pathways are Neuroscience and Pathways in cancer. The compounds cipa and sodium iodide have been mentioned in the context of this disorder. Affiliated tissues include thyroid, pituitary and skin, and related mouse phenotypes are no phenotypic analysis and tumorigenesis.

Description from OMIM:47 188470,188550,607464

Aliases & Classifications for Follicular Thyroid Carcinoma

About this section
Sources:
8Disease Ontology, 9diseasecard, 43NIH Rare Diseases, 22GTR, 47OMIM, 45Novoseek, 49Orphanet, 62UMLS, 58SNOMED-CT, 35MeSH, 40NCIt, 26ICD10 via Orphanet, 59SNOMED-CT via Orphanet, 63UMLS via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Endocrine diseases


Characteristics (Orphanet epidemiological data):

49
papillary or follicular thyroid carcinoma:
Inheritance: Sporadic; Age of onset: Adulthood


Aliases & Descriptions:

follicular thyroid carcinoma 8 43 62
thyroid carcinoma, follicular 9 43 47
thyroid cancer, follicular 43 22
follicular adenocarcinoma, well differentiated 8
follicular carcinoma of the thyroid gland 8
papillary or follicular thyroid carcinoma 49
differentiated thyroid gland carcinoma 62
well-differentiated thyroid carcinoma 49
malignant neoplasm of thyroid 62
thyroid gland adenocarcinoma 62
thyroid follicular carcinoma 45
follicular adenocarcinoma 8
follicular thyroid cancer 45
thyroid adenocarcinoma 8
follicular carcinoma 8
ftc 43


External Ids:

Disease Ontology8 DOID:3962
MeSH35 D018263
NCIt40 C8054
ICD10 via Orphanet26 C73
SNOMED-CT via Orphanet59 255028004, 255029007
UMLS via Orphanet63 C0238463

Related Diseases for Follicular Thyroid Carcinoma

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Follicular Thyroid Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 67)
idRelated DiseaseScoreTop Affiliating Genes
1goiter31.0SLC5A5, NKX2-1, RET, DIO2
2adenoma31.0NKX2-1, NTRK1, RET, DIO2
3papillary carcinoma30.6NCOA4, NKX2-1, NTRK1, RET
4follicular adenoma30.5DIO2, RET, NTRK1, NKX2-1
5graves' disease30.5DIO2, FOXE1, NKX2-1
6struma ovarii30.4NKX2-1
7thyroid adenoma30.3RET, DIO2
8papillary thyroid carcinoma30.2RET, CCDC6, NTRK1
9thyroid cancer30.2RET, CCDC6, NTRK1, NKX2-1, NCOA4, SLC5A5
10thyroiditis11.4
11hyperthyroidism10.5
12familial papillary or follicular thyroid carcinoma10.5
13mediastinitis10.4
14multinodular goiter10.4
15cervicitis10.4
16trabecular follicular adenocarcinoma10.3
17thyrotoxicosis10.3
18endotheliitis10.3
19thyroid hurthle cell carcinoma10.3
20adenocarcinoma10.2
21subacute thyroiditis10.1
22blastoma10.1
23thrombocytosis10.1
24acromegaly10.1
25situs inversus10.1
26choroiditis10.1
27primary hyperparathyroidism10.1
28pleuropulmonary blastoma10.1
29down syndrome10.1
30endemic goiter10.1
31chordoma10.1
32gingivitis10.1
33hyperparathyroidism10.1
34myasthenia gravis10.1
35paraplegia10.1
36parathyroid adenoma10.1
37pituitary adenoma10.1
38sarcoma10.1
39thymoma10.1
40soft tissue sarcoma10.1
41superior vena cava syndrome10.1
42sinusitis10.1
43hematopoietic stem cell transplantation10.1
44papillary follicular thyroid adenocarcinoma10.1
45tracheal stenosis10.1
46carney complex10.1
47pituitary tumors10.1
48thyroid cancer, anaplastic10.1NKX2-1, RET
49thymus cancer10.1NKX2-1, NTRK1
50thyroid medullary carcinoma10.1RET, NTRK1, NKX2-1

Graphical network of the top 20 diseases related to Follicular Thyroid Carcinoma:



Diseases related to follicular thyroid carcinoma

Symptoms for Follicular Thyroid Carcinoma

About this section
Sources:
47OMIM
See all sources


Clinical features from OMIM:

188470,188550,607464

Drugs & Therapeutics for Follicular Thyroid Carcinoma

About this section
Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
See all sources

Drug clinical trials:

Search ClinicalTrials for Follicular Thyroid Carcinoma

Search NIH Clinical Center for Follicular Thyroid Carcinoma

Genetic Tests for Follicular Thyroid Carcinoma

About this section
Sources:
22GTR
See all sources

Genetic tests related to Follicular Thyroid Carcinoma:

id Genetic test Affiliating Genes
1 Thyroid Cancer, Follicular22

Anatomical Context for Follicular Thyroid Carcinoma

About this section
Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Follicular Thyroid Carcinoma:

33
Thyroid, Pituitary, Skin, Bone, Lymph node, Lung, Brain, Trachea, Kidney, Endothelial, T cells, Adrenal gland, Thymus, Skeletal muscle, Spinal cord

Animal Models for Follicular Thyroid Carcinoma or affiliated genes

About this section
Sources:
37MGI
See all sources

MGI Mouse Phenotypes related to Follicular Thyroid Carcinoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00030129.8NTRK1, NKX2-1, ERC1, TRIM27, RET
2MP:00020069.5TRIM24, TRIM27, TRIM33, NKX2-1, RET

Publications for Follicular Thyroid Carcinoma

About this section
Sources:
52PubMed
See all sources

Articles related to Follicular Thyroid Carcinoma:

(show top 50)    (show all 314)
idTitleAuthorsYear
1
Follicular thyroid carcinoma with distant metastasis: outcome and prognostic factor. (24420337)
2014
2
Pituitary metastases from the oncocytic variant of follicular thyroid carcinoma: a case report and diagnostic dilemmas. (24114644)
2013
3
The role of CD147 in the invasiveness of follicular thyroid carcinoma cells. (22280229)
2012
4
Brain Metastasis from Follicular Thyroid Carcinoma: Treatment with Sorafenib. (22607583)
2012
5
Metastatic follicular thyroid carcinoma to the mandible. (23649086)
2012
6
Unresectable huge sternal and mediastinal metastasis of follicular thyroid carcinoma; radiotherapy as first-line and palliative therapy. (18561094)
2009
7
A rare case of follicular thyroid carcinoma in a patient with thyrotropin-secreting pituitary adenoma. (19390430)
2009
8
Follicular thyroid carcinoma with an eggshell calcification: report of 3 cases. (19470821)
2009
9
Multiple giant scalp metastases of a follicular thyroid carcinoma. (18694518)
2008
10
Fine needle aspiration cytology of mixed medullary-follicular thyroid carcinoma: a case report. (18540307)
2008
11
Secondary lymphoma involving metastatic follicular thyroid carcinoma to the skull: a unique example of tumor-to-tumor metastasis. (20614316)
2008
12
Prevalence and prognosis of familial follicular thyroid carcinoma. (18506092)
2008
13
An unusual presentation of recurrent follicular thyroid carcinoma. (18269121)
2008
14
Follicular thyroid carcinoma with an unusual glomeruloid pattern of growth. (18602667)
2008
15
Unusual finding on ultrasonography of follicular thyroid carcinoma including poorly differentiated thyroid carcinoma. (18788925)
2008
16
Needle track dissemination of follicular thyroid carcinoma following fine-needle aspiration biopsy: report of a case. (17186343)
2007
17
Accumulation of p27(kip1) is associated with cyclin D3 overexpression in the oxyphilic (Hurthle cell) variant of follicular thyroid carcinoma. (16798934)
2007
18
Importance of thyroglobulin levels for diagnosis and monitoring of follicular thyroid carcinoma in an adolescent with severe iodine deficiency. (17128567)
2006
19
Cutaneous metastases of follicular thyroid carcinoma: a report of four cases and a review of the literature. (16121050)
2005
20
Is patient's age a prognostic factor for follicular thyroid carcinoma in the TNM classification system? (15929665)
2005
21
Renal rupture associated with a poorly differentiated follicular thyroid carcinoma metastasizing to the thigh muscle, lung and kidney. (16157985)
2005
22
Significance of an insular component in follicular thyroid carcinoma with distant metastasis at initial presentation. (16000845)
2005
23
Follicular thyroid carcinoma: the role of histology and staging systems in predicting survival. (16244545)
2005
24
Follicular thyroid carcinoma: histology and prognosis. (15022277)
2004
25
Diagnostic applicability of dipeptidyl aminopeptidase IV activity in cytological samples for differentiating follicular thyroid carcinoma from follicular adenoma. (14718282)
2004
26
Papillary and follicular thyroid carcinomas show distinctly different microarray expression profiles and can be distinguished by a minimum of five genes. (15337802)
2004
27
Carcinoembryonic antigen mRNA in blood: distinguishing follicular thyroid carcinoma from adenoma. (14588107)
2003
28
Metastatic follicular thyroid carcinoma to the thymus in a 35-year-old woman. (12402382)
2002
29
Galectin-3 as a presurgical immunocytodiagnostic marker of minimally invasive follicular thyroid carcinoma. (11701669)
2001
30
Absence of mutations in the beta-catenin and adenomatous polyposis coli genes in papillary and follicular thyroid carcinomas. (11696170)
2001
31
Conservative management of patients with intrathyroidal well-differentiated follicular thyroid carcinoma. (11436009)
2001
32
Bilateral renal metastasis in follicular thyroid carcinoma. (10726259)
2000
33
Metastatic follicular thyroid carcinoma to the kidney: a case report. (9890493)
1999
34
Invasion of human follicular thyroid carcinoma cells in an in vivo invasion model. (10646662)
1999
35
Follicular thyroid carcinoma with rhabdoid phenotype. (10599312)
1999
36
An overview of the management of papillary and follicular thyroid carcinoma. (10365671)
1999
37
Fine-structure deletion mapping of 10q22-24 identifies regions of loss of heterozygosity and suggests that sporadic follicular thyroid adenomas and follicular thyroid carcinomas develop along distinct neoplastic pathways. (10534767)
1999
38
Papillary and follicular thyroid carcinoma. (9445411)
1998
39
Metastatic spinal cord compression as initial presentation of follicular thyroid carcinoma. (9530890)
1998
40
Microinvasive follicular thyroid carcinoma detected by fine needle aspiration skeletal metastases. A case report. (9100800)
1997
41
Surgical treatment of papillary and follicular thyroid carcinoma. (8803709)
1996
42
Memory T cells of a patient with follicular thyroid carcinoma recognize peptides derived from mutated p21 ras (Gln-->Leu61). (1282032)
1992
43
Follicular thyroid carcinoma masquerading as subacute thyroiditis. Diagnosis using ultrasonography and radionuclide thyroid angiography. (1930018)
1991
44
Cutaneous metastases from follicular thyroid carcinoma: histology, immunohistology, and electron microscopy. A report of two cases. (1809592)
1991
45
Characterization of a human follicular thyroid carcinoma cell line (UCLA RO 82 W-1). (2570483)
1989
46
Case 3. Follicular thyroid carcinoma with metastases to bone. (2913623)
1989
47
Follicular thyroid carcinoma with clear cell change showing unusual ultrastructural features. (3278637)
1988
48
Malignant schwannoma and follicular thyroid carcinoma associated with von Recklinghausen's disease. (6436417)
1984
49
T3 euthyroidism in follicular thyroid carcinoma. (629499)
1978
50
Follicular thyroid carcinoma in Denmark 1943-1968. (949916)
1976

Variations for Follicular Thyroid Carcinoma

About this section
Sources:
1 National Center for Biotechnology Information (Clinvar)
See all sources

Clinvar genetic disease variations for Follicular Thyroid Carcinoma:

1
id Gene Name Type Significance SNP ID Assembly Location
1HRASNM_005343.2(HRAS): c.181C> A (p.Gln61Lys)single nucleotide variantPathogenicrs28933406GRCh37Chr 11, 533875: 533875
2NRASNM_002524.4(NRAS): c.182A> G (p.Gln61Arg)single nucleotide variantPathogenicrs11554290GRCh37Chr 1, 115256529: 115256529
3BRAFNM_004333.4(BRAF): c.1801A> G (p.Lys601Glu)single nucleotide variantPathogenicrs121913364GRCh37Chr 7, 140453134: 140453134
4MINPP1NM_004897.4(MINPP1): c.122C> T (p.Ser41Leu)single nucleotide variantPathogenicrs119486096GRCh37Chr 10, 89264794: 89264794
5MINPP1NM_004897.4(MINPP1): c.809A> G (p.Gln270Arg)single nucleotide variantPathogenicrs104894171GRCh37Chr 10, 89268264: 89268264

Expression for genes affiliated with Follicular Thyroid Carcinoma

About this section
Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Follicular Thyroid Carcinoma

Search GEO for disease gene expression data for Follicular Thyroid Carcinoma.

Pathways for genes affiliated with Follicular Thyroid Carcinoma

About this section
Sources:
50PathCards, 5Cell Signaling Technology, 30KEGG
See all sources

Pathways related to Follicular Thyroid Carcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0NKX2-1, NTRK1, RET
29.6TFG, TPR, RET, CCDC6, NTRK1, NCOA4
39.6NCOA4, NTRK1, CCDC6, RET, TPR, TFG

Compounds for genes affiliated with Follicular Thyroid Carcinoma

About this section
Sources:
45Novoseek, 51PharmGKB, 11DrugBank, 24HMDB
See all sources

Compounds related to Follicular Thyroid Carcinoma according to GeneCards/GeneDecks:

(show all 11)
idCompoundScoreTop Affiliating Genes
1cipa4510.4RET, NTRK1
2sodium iodide4510.2SLC5A5, NKX2-1, RET
3regorafenib51 1111.1NTRK1, RET
4iodine45 2411.1SLC5A5, DIO2
5125i4510.1SLC5A5, DIO2
6iodide45 2410.9DIO2, FOXE1, NKX2-1, SLC5A5
7sodium45 2410.9SLC5A5, NKX2-1, NTRK1, FOXE1
8estrogen459.8DIO2, NTRK1, NKX2-1, NCOA4, TRIM24
9retinoic acid45 2410.8DIO2, RET, NTRK1, NKX2-1, NDUFA13, TRIM24
10cyclic amp45 2410.5RET, NTRK1, NKX2-1, S1PR3
11tyrosine458.7TRIM27, GOLGA5, TFG, TPR, DIO2, RET

GO Terms for genes affiliated with Follicular Thyroid Carcinoma

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Follicular Thyroid Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleoplasmGO:0056549.8TRIM27, TRIM33, NDUFA13, NKX2-1, TPR
2nuclear membraneGO:0319659.8TRIM27, PCM1, TPR

Biological processes related to Follicular Thyroid Carcinoma according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1response to hormoneGO:00972510.2NCOA4, NKX2-1
2peptidyl-tyrosine phosphorylationGO:01810810.2RET, NTRK1, TRIM27
3thyroid gland developmentGO:03087810.1NKX2-1, FOXE1
4thyroid hormone generationGO:00659010.1SLC5A5, FOXE1, DIO2
5positive regulation of transcription, DNA-templatedGO:0458939.9RET, FOXE1, NKX2-1, NCOA4, TRIM24
6regulation of protein stabilityGO:0316479.9TRIM24, TPR
7negative regulation of transcription from RNA polymerase II promoterGO:0001229.8TRIM27, TRIM33, NKX2-1, FOXE1, TPR
8negative regulation of transcription, DNA-templatedGO:0458929.8FOXE1, NDUFA13, TRIM33, TRIM24

Molecular functions related to Follicular Thyroid Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transmembrane receptor protein tyrosine kinase activityGO:0047149.8TRIM27, NTRK1, RET
2protein bindingGO:0055158.8TPR, RET, CCDC6, NTRK1, PCM1, NKX2-1

Products for genes affiliated with Follicular Thyroid Carcinoma

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Follicular Thyroid Carcinoma

About this section
4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet