MCID: FLL008
MIFTS: 58

Folliculitis malady

Skin diseases category
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Summaries for Folliculitis

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Wikipedia:65 Folliculitis (also known as hot tub rash) is the infection and inflammation of one or more hair... more...

MalaCards based summary: Folliculitis, also known as seborrheic dermatitis of scalp, is related to strongyloidiasis and dermatitis. An important gene associated with Folliculitis is DEFB4A (defensin, beta 4A), and among its related pathways are Immune response IL 12 signaling pathway and IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types. The compounds 5-oxoete and natalizumab have been mentioned in the context of this disorder. Affiliated tissues include skin, bone marrow and bone, and related mouse phenotypes are respiratory system and digestive/alimentary.

Aliases & Classifications for Folliculitis

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Folliculitis, Aliases & Descriptions:

Name: Folliculitis 8 10 44 62
Seborrheic Dermatitis of Scalp 62
 
Seborrhea Capitis 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin diseases


External Ids:

Disease Ontology8 DOID:4409
MeSH34 D005499

Related Diseases for Folliculitis

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Diseases related to Folliculitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 200)
idRelated DiseaseScoreTop Affiliating Genes
1strongyloidiasis30.6IL5
2dermatitis30.5CCL11, IFNG, IL4, IL5
3candidiasis30.3DEFB4A, IFNG
4tropical spastic paraparesis30.3IFNG, IL2RA
5colitis30.0IL4, IFNG, DEFB4A
6pulmonary eosinophilia30.0CCL11, IL4, IL5
7skin disease29.9DEFB4A, CCL11, IFNG, IL4, IL5
8inflammatory bowel disease29.7DEFB4A, CCL5, CCL11, IFNG, IL4
9ulcerative colitis29.6DEFB4A, CCL11, IFNG, IL4, IL2RA
10eosinophilia29.5CCL5, CCL11, IFNG, IL4, IL5, IL2RA
11arthritis29.4FCGR3A, CCL5, IFNG, IL4, FGF2
12rheumatoid arthritis29.3FCGR3A, CCL5, CCL11, IFNG, IL4, IL2RA
13leukemia29.3CCL11, IFNG, IL4, IL2RA, EGF, FGF2
14psoriasis28.4DEFB4A, FCGR3A, EGF, IL2RA, IL5, IL4
15eosinophilic pustular folliculitis11.0
16tufted hair folliculitis10.6
17aspergillosis10.6IFNG
18eosinophilic fasciitis10.5IL5
19kimura disease10.5IL5
20eosinophilia-myalgia syndrome10.5IL5
21exanthem10.5EGFR
22seborrheic infantile dermatitis10.4
23pleurisy10.4IL2RA
24alopecia10.4
25malaria10.4CCL5, IFNG
26keratoconjunctivitis10.4CCL11, IL5
27acne10.4
28quinquaud's decalvans folliculitis10.4
29lichen planus10.4DEFB4A
30chronic eosinophilic pneumonia10.4CCL11, IL5
31giant papillary conjunctivitis10.4IL5, CCL11
32eosinophilic gastroenteritis10.4CCL11, IL5
33eosinophilic esophagitis10.3IL5, CCL11
34tuberculoid leprosy10.3IFNG, IL2RA
35pleural tuberculosis10.3IFNG, IL2RA
36bullous skin disease10.3CCL5, IL5
37sinusitis10.3IL5, CCL11, DEFB4A
38esophagitis10.3IL5, CCL11
39lepromatous leprosy10.3IFNG, IL4
40autosomal dominant hyper ige syndrome10.3IFNG, IL4
41bronchitis10.2CCL11, IL5
42visceral leishmaniasis10.2IL4, IFNG
43follicular mucinosis10.2
44atrophodermia vermiculata10.2
45extrinsic allergic alveolitis10.2CCL5, IL2RA
46eosinophilic pneumonia10.2CCL5, CCL11, IL5
47bronchiolitis10.2CCL5, CCL11, IL5
48egg allergy10.2IL4, IL5
49bullous pemphigoid10.2CCL5, CCL11, IL5
50intrinsic asthma10.2IL4, IL5

Graphical network of the top 20 diseases related to Folliculitis:



Diseases related to folliculitis

Symptoms for Folliculitis

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Drugs & Therapeutics for Folliculitis

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Drug clinical trials:

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Genetic Tests for Folliculitis

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Anatomical Context for Folliculitis

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MalaCards organs/tissues related to Folliculitis:

32
Skin, Bone marrow, Bone, Neutrophil, Testes, T cells, B cells, Heart, Lung, Breast

Animal Models for Folliculitis or affiliated genes

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MGI Mouse Phenotypes related to Folliculitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.6CCL11, IFNG, IL4, IL5, EGFR
2MP:00053818.2IFNG, IL4, IL5, IL2RA, EGFR, EGF
3MP:00053918.1IFNG, IL4, EGFR, EGF, FGF2
4MP:00053898.1IFNG, IL4, IL5, EGFR, EGF, FGF2
5MP:00053767.7FCGR3A, IFNG, IL4, IL5, EGFR, FGF2
6MP:00053976.9FGF2, PTGDR2, FCGR3A, CCL5, CCL11, IFNG
7MP:00053876.8PTGDR2, FCGR3A, CCL5, CCL11, IFNG, IL4

Publications for Folliculitis

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Articles related to Folliculitis:

(show top 50)    (show all 541)
idTitleAuthorsYear
1
Eosinophilic pustular folliculitis associated with SAczary syndrome. (24708187)
2014
2
Guidelines for the diagnosis and antimicrobial therapy of canine superficial bacterial folliculitis (Antimicrobial Guidelines Working Group of the International Society for Companion Animal Infectious Diseases). (24720433)
2014
3
Microbiology of folliculitis: a histological study of 39 cases. (23656553)
2014
4
Widespread eosinophilic pustular folliculitis in a nonimmunocompromised patient. (24751524)
2014
5
Successful treatment of recalcitrant folliculitis barbae and pseudofolliculitis barbae with photodynamic therapy. (24284123)
2013
6
Canine superficial bacterial folliculitis: Current understanding of its etiology, diagnosis and treatment. (24345778)
2013
7
Eosinophilic pustular folliculitis: a review of the Japanese published works. (23083212)
2013
8
First step in the differential diagnosis of folliculitis: cytology. (22639852)
2013
9
First evidence of bacterial biofilms in the anaerobe part of scalp hair follicles: a pilot comparative study in folliculitis decalvans. (22779760)
2013
10
Treatment of folliculitis decalvans with tacrolimus ointment. (22250634)
2012
11
Folliculitis induced by EGFR inhibitors, preventive and curative efficacy of tetracyclines in the management and incidence rates according to the type of EGFR inhibitor administered: a systematic literature review. (22426526)
2012
12
Successful use of infliximab in a patient with recalcitrant folliculitis decalvans. (22676386)
2012
13
Atypical clinical appearance of eosinophilic pustular folliculitis of seborrheic areas of the face. (22940757)
2012
14
Human immunodeficiency virus (HIV)-associated eosinophilic folliculitis and follicular mucinosis in a black woman. (20964654)
2010
15
Eosinophilic pustular folliculitis: case report and review of the literature. (21140927)
2010
16
Erythematous and edematous eruption of the face. Eosinophilic pustular folliculitis. (20883260)
2010
17
Clinicopathological study of itchy folliculitis in HIV-infected patients. (20445296)
2010
18
Recipient area folliculitis after follicular-unit transplantation: characterization of clinical features and analysis of associated factors. (20533937)
2010
19
Treatment of folliculitis with monochromatic excimer light (308 nm). (18946200)
2009
20
Tinea capitis due to Trichophyton soudanense mimicking bacterial folliculitis. (17305781)
2007
21
Allopurinol induced generalized eosinophilic pustular folliculitis. (17034470)
2006
22
Eosinophilic folliculitis: before and after the introduction of antiretroviral therapy. (16230559)
2005
23
A review of 55 cases of cutaneous lymphoid hyperplasia: reassessment of the histopathologic findings leading to reclassification of 4 lesions as cutaneous marginal zone lymphoma and 19 as pseudolymphomatous folliculitis. (15948117)
2005
24
Efficacy of transdermal nicotine patches for eosinophilic pustular folliculitis. (15888180)
2005
25
Pityrosporum folliculitis during pregnancy: a possible cause of pruritic folliculitis of pregnancy. (15761438)
2005
26
Topical tacrolimus for effective treatment of eosinophilic folliculitis associated with human immunodeficiency virus infection. (16230556)
2005
27
Folliculitis: recognition and management. (15554731)
2004
28
Tufted hair folliculitis associated with pemphigus vulgaris. (12705759)
2003
29
Trauma-induced perforating folliculitis. (14727624)
2003
30
A case of tufted hair folliculitis. (12184641)
2002
31
Eosinophilic pustular folliculitis in association with nevoid basal cell carcinoma syndrome. (11558878)
2001
32
Tufted hair folliculitis: response to topical therapy with nadifloxacin. (10356403)
1999
33
Photo quiz: fungal folliculitis. (10626098)
1999
34
Itchy folliculitis and human immunodeficiency virus infection: clinicopathological and immunological features, pathogenesis and treatment. (10417509)
1999
35
What is folliculitis? (9648324)
1998
36
Folliculitis spinulosa decalvans: successful therapy with dapsone. (9810924)
1998
37
Candida folliculitis mimicking tinea barbae. (9169333)
1997
38
Disseminate and persistent infundibulo-folliculitis. (20947997)
1996
39
A case of eosinophilic pustular folliculitis (Ofuji's disease) induced by patch and challenge tests with indeloxazine hydrochloride. (8772029)
1996
40
Minocycline in chronic folliculitis of legs. (20948111)
1996
41
I-131 accumulation in folliculitis of the scalp. (8896935)
1996
42
Chronic folliculitis in Sri Lanka. (20947986)
1996
43
Ciprofloxacin therapy in chronic folliculitis of legs. (20952957)
1995
44
Folliculitis decalvans and human T cell lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis. (7756498)
1995
45
Eosinophilic folliculitis occurring after bone marrow autograft in a patient with non-Hodgkin's lymphoma. (8174047)
1994
46
Eosinophilic pustular folliculitis responding to UVB therapy. (8335748)
1993
47
Hookworm folliculitis. (2006880)
1991
48
Eosinophilic pustular folliculitis in the acquired immunodeficiency syndrome. Treatment with ultraviolet B phototherapy. (3362166)
1988
49
Eosinophilic pustular folliculitis. Studies on possible chemotactic factors involved in the formation of pustules. (3511943)
1986
50
Hemihypertrophy with unilateral folliculitis and acne. (161466)
1979

Variations for Folliculitis

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Expression for genes affiliated with Folliculitis

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Expression patterns in normal tissues for genes affiliated with Folliculitis

Search GEO for disease gene expression data for Folliculitis.

Pathways for genes affiliated with Folliculitis

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Pathways related to Folliculitis according to GeneCards/GeneDecks:

(show top 50)    (show all 63)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9IFNG, IL2RA
2
Show member pathways
9.9IL2RA, IFNG
39.7IL5, IL4
4
Show member pathways
Immune response CD16 signaling in NK cells60
9.5FCGR3A, IFNG, IL4
5
Show member pathways
EGFR-dependent Endothelin signaling events37
9.5EGF, EGFR
69.5EGF, EGFR
79.5CCL11, IL4, IL5
89.5CCL11, IL4, IL5
99.5IFNG, IL4, IL5
109.5IL5, IL4, IFNG
119.5IL5, IL4, IFNG
129.5IL5, IL4, IFNG
13
Show member pathways
BCR signaling pathway37
TCR Signaling Pathway37
9.5IL5, IL4, IFNG
14
Show member pathways
Immune response IL 12 induced IFN gamma production60
9.5IFNG, IL4, IL2RA
159.4IL2RA, IL4, CCL5
169.4IL4, IL5, IL2RA
17
Show member pathways
Transcription NF kB signaling pathway60
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response60
9.3IL4, IFNG, CCL11, DEFB4A
18
Show member pathways
9.3IL5, IL2RA, EGFR
19
Show member pathways
9.3IL5, IL2RA, EGFR
209.3IFNG, IL4, EGFR
219.2EGF, EGFR, IFNG
229.2EGF, EGFR, IFNG
23
Show member pathways
9.2IFNG, EGFR, EGF
249.2IFNG, EGFR, EGF
25
Show member pathways
9.2FCGR3A, IFNG, IL4, IL5
26
Show member pathways
Immune response IL 22 signaling pathway60
G protein signaling N RAS regulation pathway60
9.2IL2RA, EGFR, EGF
279.2EGF, EGFR, IL2RA
28
Show member pathways
9.2CCL5, IFNG, IL4, IL2RA
299.1IFNG, IL4, IL5, IL2RA
30
Show member pathways
Type III interferon signaling37
9.1IL2RA, IL5, IL4, IFNG
31
Show member pathways
Calcium signaling in the CD4+ TCR pathway37
9.1IL2RA, IL5, IL4, IFNG
32
Show member pathways
9.1EGFR, EGF, FGF2
339.1EGFR, EGF, FGF2
34
Show member pathways
Signaling Pathways in Glioblastoma37
9.1FGF2, EGF, EGFR
35
Show member pathways
8.9CCL5, CCL11, EGFR, EGF
36
Show member pathways
8.9CCL11, IFNG, IL4, IL5, IL2RA
37
Show member pathways
8.8IL2RA, EGFR, EGF, FGF2
38
Show member pathways
8.8IL2RA, EGFR, EGF, FGF2
398.8IL2RA, EGFR, EGF, FGF2
40
Show member pathways
8.8FGF2, EGF, EGFR, IL2RA
418.4IL4, IL2RA, EGFR, EGF, FGF2
42
Show member pathways
8.4IL4, IL2RA, EGFR, EGF, FGF2
43
Show member pathways
8.1IFNG, IL4, IL2RA, EGFR, EGF, FGF2
44
Show member pathways
8.0FCGR3A, CD160, EGFR, EGF, FGF2
45
Show member pathways
7.9PTGDR2, CCL5, CCL11, EGFR, EGF, FGF2
46
Show member pathways
7.6CCL5, CCL11, IFNG, IL4, IL5, IL2RA
47
Show member pathways
7.5EGF, EGFR, IL2RA, IL5, IL4, CCL11
48
Show member pathways
7.5CCL5, FGF2, EGF, EGFR, IL2RA, IL5
49
Show member pathways
7.5CCL5, CCL11, IL4, IL5, IL2RA, EGFR
50
Show member pathways
7.2FGF2, CCL5, CCL11, IFNG, IL4, IL5

Compounds for genes affiliated with Folliculitis

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Compounds related to Folliculitis according to GeneCards/GeneDecks:

(show top 50)    (show all 188)
idCompoundScoreTop Affiliating Genes
15-oxoete449.7CCL11, CCL5, IL5
2natalizumab44 1110.6IL2RA, IFNG, FCGR3A
3pranlukast44 28 1111.6IL5, CCL11, CCL5, IL4
4salmeterol44 50 28 1112.6CCL5, CCL11, IL4, IL5
5glatiramer acetate44 1110.5IL4, IL5, IFNG, CCL5
6c-d4t449.5IL5, IL4, IL2RA
7amphotericin b449.5CCL5, IFNG, IL5, IL4
8rolipram44 61 2811.5CCL11, IFNG, IL5, IL4
9montelukast44 50 28 1112.5IL2RA, IL5, IL4, CCL11
10gm-csf44 2810.5CCL5, IL4, IFNG, IL5
11con a449.4IL5, IL2RA, IFNG, IL4
12methacholine44 50 1111.4CCL5, CCL11, IL5, IL4
138-chloro-camp449.4EGFR, EGF, FGF2
14budesonide44 50 1111.3CCL5, IL4, IFNG, CCL11, IL5
15fluticasone propionate44 50 61 1112.3CCL5, CCL11, IFNG, IL4, IL5
16poly(i-c)449.3IL5, CCL5, CCL11, IL4, IFNG
17anti-fungal449.3DEFB4A, IFNG, IL5, GNLY
18tarc449.3CCL11, IFNG, IL4, CCL5, IL5
19infliximab44 50 1111.3IFNG, IL4, IL2RA, FGF2
20ivig449.2IL2RA, FCGR3A, IL5, IL4, IFNG
2115-deoxy-delta-12,14-prostaglandin j2449.2IL4, IFNG, FGF2, CCL11
22il 10449.2IL5, IL4, IL2RA, IFNG, CCL5
23prednisolone44 28 1111.2IFNG, IL5, IL2RA, CCL11, FGF2
24thalidomide44 50 61 1112.2IFNG, IL5, FGF2, IL2RA, CCL5
25methylcellulose449.1IFNG, IL4, IL5, EGF, FGF2
26allergens449.0IFNG, IL5, IL4, CCL11, PTGDR2
27tacrolimus44 50 1111.0IL4, IL2RA, CCL5, CCL11, IFNG, IL5
28hydrocortisone44 2 61 1111.8FGF2, CCL5, IFNG, IL4, EGF, IL5
29bleomycin44 119.7IL2RA, IL5, IL4, FGF2
30calcitriol44 61 24 1111.7IL4, FGF2, IFNG, CCL5, EGF, IL2RA
31n acetylcysteine448.5EGFR, IL4, CCL11, CCL5, IL2RA
32paraffin448.5FGF2, IL5, IL2RA, EGFR, DEFB4A, IL4
33heparin44 28 24 1111.5EGF, IL2RA, IL5, CCL11, CCL5, DEFB4A
34ionomycin448.5GNLY, CCL5, CCL11, IFNG, IL4, IL5
35thymidine44 249.4IFNG, IL4, CCL11, IL5, IL2RA, FGF2
36ly294002448.2FGF2, EGF, EGFR, IL5, CCL11, CCL5
37cycloheximide448.2CCL5, IFNG, IL4, IL5, EGFR, FGF2
38cysteine448.1CCL5, DEFB4A, IL4, IL2RA, IFNG, EGF
39retinoic acid44 249.1DEFB4A, CCL5, CCL11, IL5, IFNG, FGF2
40histamine44 28 2410.0DEFB4A, CCL5, IL2RA, CCL11, IL4, IFNG
41indomethacin44 28 61 1110.9IFNG, PTGDR2, IL2RA, EGF, IL4, CCL5
42dexamethasone44 50 28 1110.9CCL11, DEFB4A, CCL5, IFNG, IL4, IL5
43genistein44 28 61 2 24 1112.8EGFR, IFNG, IL5, FGF2, DEFB4A, IL2RA
44cyclosporin a44 28 619.8FGF2, CD160, CCL11, CCL5, IFNG, IL4
45sb 20358044 618.8EGF, EGFR, FGF2, IL5, IL4, DEFB4A
46herbimycin a44 618.7IL4, IFNG, FCGR3A, IL2RA, CCL11, EGFR
47pge2447.7IL2RA, EGFR, FGF2, EGF, IL5, CCL5
48vegf447.6CCL11, IL2RA, EGF, CCL5, FGF2, IL4
49rantes447.6IFNG, IL2RA, IL5, DEFB4A, GNLY, PTGDR2
50tyrosine446.6FGF2, EGF, EGFR, DEFB4A, FCGR3A, CD160

GO Terms for genes affiliated with Folliculitis

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Cellular components related to Folliculitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.2IL2RA, IL4, IFNG, FCGR3A
2extracellular regionGO:0055767.7DEFB4A, FCGR3A, CCL5, CCL11, IFNG, IL5
3extracellular spaceGO:0056156.9FGF2, GNLY, CCL5, CCL11, IFNG, IL4

Biological processes related to Folliculitis according to GeneCards/GeneDecks:

(show all 32)
idNameGO IDScoreTop Affiliating Genes
1eosinophil chemotaxisGO:04824510.3CCL5, CCL11
2positive regulation of isotype switching to IgG isotypesGO:04830410.2IFNG, IL4
3positive regulation of MHC class II biosynthetic processGO:04534810.2IL4, IFNG
4positive regulation of chemokine biosynthetic processGO:04508010.1IL4, IFNG
5positive regulation of JAK-STAT cascadeGO:04642710.1CCL5, IL5
6defense response to protozoanGO:04283210.1IFNG, IL4
7positive regulation of T cell differentiationGO:04558210.0IL4, IL2RA
8positive regulation of cerebellar granule cell precursor proliferationGO:02194010.0FGF2, EGF
9ERK1 and ERK2 cascadeGO:07037110.0EGF, CCL11
10response to virusGO:00961510.0IFNG, CCL11, CCL5
11positive regulation of cell adhesionGO:0457859.9IFNG, CCL5
12positive regulation of activated T cell proliferationGO:0421049.9IL4, IL2RA
13positive regulation of T cell proliferationGO:0421029.9CCL5, IFNG, IL4
14positive chemotaxisGO:0509189.9FGF2, CCL5
15positive regulation of catenin import into nucleusGO:0354139.8EGF, EGFR
16defense response to bacteriumGO:0427429.8DEFB4A, GNLY, IFNG
17positive regulation of cell migrationGO:0303359.7EGFR, CCL11, CCL5
18positive regulation of nitric oxide biosynthetic processGO:0454299.7EGFR, IFNG
19positive regulation of phosphorylationGO:0423279.6CCL5, EGFR, EGF
20positive regulation of B cell proliferationGO:0308909.4IL5, IL4
21negative regulation of epidermal growth factor receptor signaling pathwayGO:0420599.4EGFR, EGF
22phosphatidylinositol-mediated signalingGO:0480159.4FGF2, EGF, EGFR
23fibroblast growth factor receptor signaling pathwayGO:0085439.3FGF2, EGF, EGFR
24regulation of immune responseGO:0507769.3CD160, IL4, FCGR3A
25Fc-epsilon receptor signaling pathwayGO:0380959.3FGF2, EGF, EGFR
26epidermal growth factor receptor signaling pathwayGO:0071739.2EGFR, EGF, FGF2
27positive regulation of transcription, DNA-templatedGO:0458939.1IL4, IL5, EGF, FGF2
28cellular defense responseGO:0069689.1CD160, IL4, GNLY
29innate immune responseGO:0450879.0DEFB4A, FCGR3A, EGFR, EGF, FGF2
30cell surface receptor signaling pathwayGO:0071668.9EGFR, CD160, IL2RA, IFNG
31chemotaxisGO:0069358.7FGF2, IL4, CCL11, CCL5, PTGDR2, DEFB4A
32immune responseGO:0069558.4DEFB4A, PTGDR2, FCGR3A, CCL11, IL4, IL5

Molecular functions related to Folliculitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemoattractant activityGO:0420569.8FGF2, CCL5
2growth factor activityGO:0080838.8FGF2, EGF, IL5, IL4
3cytokine activityGO:0051258.8IFNG, IL4, IL5, FGF2

Products for genes affiliated with Folliculitis

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Sources for Folliculitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet