MCID: FLL008
MIFTS: 58

Folliculitis malady

Skin diseases category
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Summaries for Folliculitis

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65Wikipedia, 33MalaCards
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Wikipedia:65 Folliculitis (also known as hot tub rash) is the infection and inflammation of one or more hair... more...

MalaCards: Folliculitis, also known as seborrheic dermatitis of scalp, is related to dermatitis and skin disease. An important gene associated with Folliculitis is DEFB4A (defensin, beta 4A), and among its related pathways are Immune response IL 12 signaling pathway and IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types. The compounds 5-oxoete and natalizumab have been mentioned in the context of this disorder. Affiliated tissues include skin, bone marrow and bone, and related mouse phenotypes are respiratory system and digestive/alimentary.

Aliases & Classifications for Folliculitis

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8Disease Ontology, 10DISEASES, 45Novoseek, 62UMLS, 58SNOMED-CT, 35MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin diseases


Aliases & Descriptions:

folliculitis 8 10 45 62
seborrheic dermatitis of scalp 62
seborrhea capitis 8
folliculitis nos 8


External Ids:

Disease Ontology8 DOID:4409
MeSH35 D005499

Related Diseases for Folliculitis

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17GeneCards, 18GeneDecks
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Diseases related to Folliculitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 191)
idRelated DiseaseScoreTop Affiliating Genes
1dermatitis30.5IFNG, IL4, IL5, CCL11
2skin disease30.0IFNG, IL4, CCL11, IL5, DEFB4A
3strongyloidiasis30.0IL5
4candidiasis29.9DEFB4A, IFNG
5tropical spastic paraparesis29.9IFNG, IL2RA
6eosinophilia29.9IL2RA, IL5, CCL5, IL4, IFNG, CCL11
7pulmonary eosinophilia29.9IL4, IL5, CCL11
8leukemia29.8EGF, IL4, IFNG, IL2RA, FGF2, CCL11
9inflammatory bowel disease29.8IL4, IFNG, CCL11, CCL5, DEFB4A
10ulcerative colitis29.8IL4, CCL11, IFNG, DEFB4A, IL2RA
11arthritis29.7IFNG, IL4, CCL5, FGF2, FCGR3A
12rheumatoid arthritis29.7FCGR3A, CCL5, IL2RA, IFNG, CCL11, IL4
13psoriasis29.5DEFB4A, FCGR3A, CCL5, EGF, CCL11, IL2RA
14eosinophilic pustular folliculitis11.0
15tufted hair folliculitis10.6
16alopecia10.4
17acne10.4
18quinquaud's decalvans folliculitis10.4
19seborrheic infantile dermatitis10.3
20follicular mucinosis10.2
21pemphigus10.2
22acquired immunodeficiency syndrome10.2
23tinea barbae10.2
24pyoderma10.2
25aspergillosis10.1IFNG
26herpes zoster10.1
27keratosis10.1
28smallpox10.1
29tinea capitis10.1
30atrophodermia vermiculata10.1
31cutaneous larva migrans10.1
32pemphigus vulgaris10.1
33atrophoderma vermiculata10.1
34eosinophilic fasciitis10.1IL5
35kimura disease10.1IL5
36eosinophilia-myalgia syndrome10.1IL5
37exanthem10.1EGFR
38pleurisy10.1IL2RA
39malaria10.1IFNG, CCL5
40keratoconjunctivitis10.1CCL11, IL5
41lichen planus10.1DEFB4A
42chronic eosinophilic pneumonia10.1IL5, CCL11
43giant papillary conjunctivitis10.1CCL11, IL5
44eosinophilic gastroenteritis10.1CCL11, IL5
45eosinophilic esophagitis10.1CCL11, IL5
46tuberculoid leprosy10.1IL2RA, IFNG
47pleural tuberculosis10.1IFNG, IL2RA
48bullous skin disease10.1IL5, CCL5
49esophagitis10.1IL5, CCL11
50sinusitis10.1CCL11, DEFB4A, IL5

Graphical network of the top 20 diseases related to Folliculitis:



Diseases related to folliculitis

Symptoms for Folliculitis

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Drugs & Therapeutics for Folliculitis

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42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Folliculitis

Search NIH Clinical Center for Folliculitis

Genetic Tests for Folliculitis

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Anatomical Context for Folliculitis

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33MalaCards
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MalaCards organs/tissues related to Folliculitis:

33
Skin, Bone marrow, Bone, Testes, T cells, Heart, Lung, Breast, B cells

Animal Models for Folliculitis or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Folliculitis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.6CCL11, IFNG, IL4, IL5, EGFR
2MP:00053818.2IFNG, IL4, IL5, IL2RA, EGFR, EGF
3MP:00053918.1IFNG, IL4, EGFR, EGF, FGF2
4MP:00053898.1IFNG, IL4, IL5, EGFR, EGF, FGF2
5MP:00053767.7FCGR3A, IFNG, IL4, IL5, EGFR, FGF2
6MP:00053976.9FGF2, PTGDR2, FCGR3A, CCL5, CCL11, IFNG
7MP:00053876.8PTGDR2, FCGR3A, CCL5, CCL11, IFNG, IL4

Publications for Folliculitis

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52PubMed
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Articles related to Folliculitis:

(show top 50)    (show all 520)
idTitleAuthorsYear
1
Microbiology of folliculitis: a histological study of 39 cases. (23656553)
2014
2
Successful treatment of recalcitrant folliculitis barbae and pseudofolliculitis barbae with photodynamic therapy. (24284123)
2013
3
Canine superficial bacterial folliculitis: Current understanding of its etiology, diagnosis and treatment. (24345778)
2013
4
Eosinophilic pustular folliculitis: a review of the Japanese published works. (23083212)
2013
5
First step in the differential diagnosis of folliculitis: cytology. (22639852)
2013
6
First evidence of bacterial biofilms in the anaerobe part of scalp hair follicles: a pilot comparative study in folliculitis decalvans. (22779760)
2013
7
Treatment of folliculitis decalvans with tacrolimus ointment. (22250634)
2012
8
Folliculitis induced by EGFR inhibitors, preventive and curative efficacy of tetracyclines in the management and incidence rates according to the type of EGFR inhibitor administered: a systematic literature review. (22426526)
2012
9
Successful use of infliximab in a patient with recalcitrant folliculitis decalvans. (22676386)
2012
10
Atypical clinical appearance of eosinophilic pustular folliculitis of seborrheic areas of the face. (22940757)
2012
11
Human immunodeficiency virus (HIV)-associated eosinophilic folliculitis and follicular mucinosis in a black woman. (20964654)
2010
12
Eosinophilic pustular folliculitis: case report and review of the literature. (21140927)
2010
13
Erythematous and edematous eruption of the face. Eosinophilic pustular folliculitis. (20883260)
2010
14
Clinicopathological study of itchy folliculitis in HIV-infected patients. (20445296)
2010
15
Recipient area folliculitis after follicular-unit transplantation: characterization of clinical features and analysis of associated factors. (20533937)
2010
16
Treatment of folliculitis with monochromatic excimer light (308 nm). (18946200)
2009
17
Tinea capitis due to Trichophyton soudanense mimicking bacterial folliculitis. (17305781)
2007
18
Epidermal growth factor receptor inhibitor-related folliculitis. (17725926)
2007
19
Allopurinol induced generalized eosinophilic pustular folliculitis. (17034470)
2006
20
Eosinophilic folliculitis in a Caucasian patient: association with toxocariasis? (17062052)
2006
21
Eosinophilic folliculitis: before and after the introduction of antiretroviral therapy. (16230559)
2005
22
A review of 55 cases of cutaneous lymphoid hyperplasia: reassessment of the histopathologic findings leading to reclassification of 4 lesions as cutaneous marginal zone lymphoma and 19 as pseudolymphomatous folliculitis. (15948117)
2005
23
Efficacy of transdermal nicotine patches for eosinophilic pustular folliculitis. (15888180)
2005
24
Pityrosporum folliculitis during pregnancy: a possible cause of pruritic folliculitis of pregnancy. (15761438)
2005
25
Topical tacrolimus for effective treatment of eosinophilic folliculitis associated with human immunodeficiency virus infection. (16230556)
2005
26
Folliculitis: recognition and management. (15554731)
2004
27
Tufted hair folliculitis associated with pemphigus vulgaris. (12705759)
2003
28
Trauma-induced perforating folliculitis. (14727624)
2003
29
A case of tufted hair folliculitis. (12184641)
2002
30
Eosinophilic pustular folliculitis in association with nevoid basal cell carcinoma syndrome. (11558878)
2001
31
Tufted hair folliculitis: response to topical therapy with nadifloxacin. (10356403)
1999
32
Photo quiz: fungal folliculitis. (10626098)
1999
33
Itchy folliculitis and human immunodeficiency virus infection: clinicopathological and immunological features, pathogenesis and treatment. (10417509)
1999
34
What is folliculitis? (9648324)
1998
35
Folliculitis spinulosa decalvans: successful therapy with dapsone. (9810924)
1998
36
HIV-associated eosinophilic pustular folliculitis: successful treatment of a Japanese patient with UVB phototherapy. (9575681)
1998
37
Candida folliculitis mimicking tinea barbae. (9169333)
1997
38
Disseminate and persistent infundibulo-folliculitis. (20947997)
1996
39
A case of eosinophilic pustular folliculitis (Ofuji's disease) induced by patch and challenge tests with indeloxazine hydrochloride. (8772029)
1996
40
Minocycline in chronic folliculitis of legs. (20948111)
1996
41
I-131 accumulation in folliculitis of the scalp. (8896935)
1996
42
Chronic folliculitis in Sri Lanka. (20947986)
1996
43
Ciprofloxacin therapy in chronic folliculitis of legs. (20952957)
1995
44
Folliculitis decalvans and human T cell lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis. (7756498)
1995
45
Eosinophilic folliculitis occurring after bone marrow autograft in a patient with non-Hodgkin's lymphoma. (8174047)
1994
46
Eosinophilic pustular folliculitis responding to UVB therapy. (8335748)
1993
47
Hookworm folliculitis. (2006880)
1991
48
Eosinophilic pustular folliculitis in the acquired immunodeficiency syndrome. Treatment with ultraviolet B phototherapy. (3362166)
1988
49
Eosinophilic pustular folliculitis. Studies on possible chemotactic factors involved in the formation of pustules. (3511943)
1986
50
Hemihypertrophy with unilateral folliculitis and acne. (161466)
1979

Variations for Folliculitis

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Expression for genes affiliated with Folliculitis

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Folliculitis

Search GEO for disease gene expression data for Folliculitis.

Pathways for genes affiliated with Folliculitis

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Sources:
50PathCards, 60Thomson Reuters, 54R&D Systems, 30KEGG, 55Reactome, 38NCBI BioSystems Database, 12EMD Millipore, 53QIAGEN, 5Cell Signaling Technology, 61Tocris Bioscience
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Pathways related to Folliculitis according to GeneCards/GeneDecks:

(show top 50)    (show all 63)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9IFNG, IL2RA
2
Show member pathways
9.9IL2RA, IFNG
39.7IL4, IL5
4
Show member pathways
Immune response CD16 signaling in NK cells60
9.5IL4, IFNG, FCGR3A
5
Show member pathways
EGFR-dependent Endothelin signaling events38
9.5EGFR, EGF
69.5EGFR, EGF
79.5IL4, CCL11, IL5
89.5CCL11, IL5, IL4
9
Show member pathways
BCR signaling pathway38
TCR Signaling Pathway38
9.5IFNG, IL4, IL5
109.5IL4, IL5, IFNG
119.5IFNG, IL5, IL4
129.5IL5, IFNG, IL4
139.5IL5, IL4, IFNG
14
Show member pathways
Immune response IL 12 induced IFN gamma production60
9.5IFNG, IL4, IL2RA
159.4IL2RA, CCL5, IL4
169.4IL5, IL4, IL2RA
17
Show member pathways
Transcription NF kB signaling pathway60
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response60
9.3DEFB4A, CCL11, IFNG, IL4
18
Show member pathways
9.3IL2RA, EGFR, IL5
19
Show member pathways
9.3IL5, IL2RA, EGFR
209.3IFNG, IL4, EGFR
21
Show member pathways
9.2EGF, EGFR, IFNG
229.2EGFR, EGF, IFNG
239.2IFNG, EGFR, EGF
249.2EGF, IFNG, EGFR
25
Show member pathways
9.2IFNG, FCGR3A, IL5, IL4
26
Show member pathways
Immune response IL 22 signaling pathway60
G protein signaling N RAS regulation pathway60
9.2IL2RA, EGF, EGFR
279.2IL2RA, EGF, EGFR
28
Show member pathways
9.2IFNG, IL4, CCL5, IL2RA
29
Show member pathways
Type III interferon signaling38
9.1IL4, IL2RA, IL5, IFNG
30
Show member pathways
Calcium signaling in the CD4+ TCR pathway38
9.1IL2RA, IL5, IFNG, IL4
319.1IFNG, IL5, IL2RA, IL4
32
Show member pathways
Signaling Pathways in Glioblastoma38
9.1EGFR, FGF2, EGF
339.1FGF2, EGF, EGFR
34
Show member pathways
9.1FGF2, EGFR, EGF
35
Show member pathways
8.9EGF, EGFR, CCL5, CCL11
36
Show member pathways
8.9IL2RA, IL5, IL4, IFNG, CCL11
37
Show member pathways
8.8EGF, FGF2, EGFR, IL2RA
388.8FGF2, EGF, EGFR, IL2RA
39
Show member pathways
8.8FGF2, EGF, EGFR, IL2RA
40
Show member pathways
8.8FGF2, IL2RA, EGFR, EGF
41
Show member pathways
8.4EGF, EGFR, IL2RA, IL4, FGF2
428.4FGF2, IL2RA, EGF, IL4, EGFR
43
Show member pathways
8.1IFNG, FGF2, IL4, EGF, IL2RA, EGFR
44
Show member pathways
8.0FGF2, EGF, EGFR, FCGR3A, CD160
45
Show member pathways
7.9EGF, EGFR, CCL11, CCL5, PTGDR2, FGF2
46
Show member pathways
7.6IL4, IL5, CCL11, CCL5, EGF, IL2RA
47
Show member pathways
7.5IL4, CCL11, CCL5, IL2RA, EGFR, IL5
48
Show member pathways
7.5CCL11, CCL5, IL4, FGF2, EGF, EGFR
49
Show member pathways
7.5CCL5, CCL11, IL4, IL5, IL2RA, EGFR
50
Show member pathways
7.2FGF2, CCL5, CCL11, IFNG, IL4, IL5

Compounds for genes affiliated with Folliculitis

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45Novoseek, 11DrugBank, 29IUPHAR, 51PharmGKB, 61Tocris Bioscience, 3BitterDB, 24HMDB
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Compounds related to Folliculitis according to GeneCards/GeneDecks:

(show top 50)    (show all 188)
idCompoundScoreTop Affiliating Genes
15-oxoete459.7CCL11, CCL5, IL5
2natalizumab45 1110.6IL2RA, IFNG, FCGR3A
3pranlukast45 29 1111.6IL5, CCL11, CCL5, IL4
4salmeterol45 51 29 1112.6CCL5, CCL11, IL4, IL5
5glatiramer acetate45 1110.5IL4, IL5, IFNG, CCL5
6c-d4t459.5IL5, IL4, IL2RA
7amphotericin b459.5CCL5, IFNG, IL5, IL4
8rolipram45 61 2911.5CCL11, IFNG, IL5, IL4
9montelukast45 51 29 1112.5IL2RA, IL5, IL4, CCL11
10gm-csf45 2910.5CCL5, IL4, IFNG, IL5
11con a459.4IL5, IL2RA, IFNG, IL4
12methacholine45 51 1111.4CCL5, CCL11, IL5, IL4
138-chloro-camp459.4EGFR, EGF, FGF2
14budesonide45 51 1111.3CCL5, IL4, IFNG, CCL11, IL5
15fluticasone propionate45 51 61 1112.3CCL5, CCL11, IFNG, IL4, IL5
16poly(i-c)459.3IL5, CCL5, CCL11, IL4, IFNG
17anti-fungal459.3DEFB4A, IFNG, IL5, GNLY
18tarc459.3CCL11, IFNG, IL4, CCL5, IL5
19infliximab45 51 1111.3IFNG, IL4, IL2RA, FGF2
20ivig459.2IL2RA, FCGR3A, IL5, IL4, IFNG
2115-deoxy-delta-12,14-prostaglandin j2459.2IL4, IFNG, FGF2, CCL11
22il 10459.2IL5, IL4, IL2RA, IFNG, CCL5
23prednisolone45 29 1111.2IFNG, IL5, IL2RA, CCL11, FGF2
24thalidomide45 51 61 1112.2IFNG, IL5, FGF2, IL2RA, CCL5
25methylcellulose459.1IFNG, IL4, IL5, EGF, FGF2
26allergens459.0IFNG, IL5, IL4, CCL11, PTGDR2
27tacrolimus45 51 1111.0IL4, IL2RA, CCL5, CCL11, IFNG, IL5
28hydrocortisone45 3 61 1111.8FGF2, CCL5, IFNG, IL4, EGF, IL5
29bleomycin45 119.7IL2RA, IL5, IL4, FGF2
30calcitriol45 61 24 1111.7IL4, FGF2, IFNG, CCL5, EGF, IL2RA
31n acetylcysteine458.5EGFR, IL4, CCL11, CCL5, IL2RA
32paraffin458.5FGF2, IL5, IL2RA, EGFR, DEFB4A, IL4
33heparin45 29 24 1111.5EGF, IL2RA, IL5, CCL11, CCL5, DEFB4A
34ionomycin458.5GNLY, CCL5, CCL11, IFNG, IL4, IL5
35thymidine45 249.4IFNG, IL4, CCL11, IL5, IL2RA, FGF2
36ly294002458.2FGF2, EGF, EGFR, IL5, CCL11, CCL5
37cycloheximide458.2CCL5, IFNG, IL4, IL5, EGFR, FGF2
38cysteine458.1CCL5, DEFB4A, IL4, IL2RA, IFNG, EGF
39retinoic acid45 249.1DEFB4A, CCL5, CCL11, IL5, IFNG, FGF2
40histamine45 29 2410.0DEFB4A, CCL5, IL2RA, CCL11, IL4, IFNG
41indomethacin45 29 61 1110.9IFNG, PTGDR2, IL2RA, EGF, IL4, CCL5
42dexamethasone45 51 29 1110.9CCL11, DEFB4A, CCL5, IFNG, IL4, IL5
43genistein45 29 61 3 24 1112.8EGFR, IFNG, IL5, FGF2, DEFB4A, IL2RA
44cyclosporin a45 29 619.8FGF2, CD160, CCL11, CCL5, IFNG, IL4
45sb 20358045 618.8EGF, EGFR, FGF2, IL5, IL4, DEFB4A
46herbimycin a45 618.7IL4, IFNG, FCGR3A, IL2RA, CCL11, EGFR
47pge2457.7IL2RA, EGFR, FGF2, EGF, IL5, CCL5
48vegf457.6CCL11, IL2RA, EGF, CCL5, FGF2, IL4
49rantes457.6IFNG, IL2RA, IL5, DEFB4A, GNLY, PTGDR2
50tyrosine456.6FGF2, EGF, EGFR, DEFB4A, FCGR3A, CD160

GO Terms for genes affiliated with Folliculitis

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16Gene Ontology
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Cellular components related to Folliculitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.2IL2RA, IL4, IFNG, FCGR3A
2extracellular regionGO:0055767.7DEFB4A, FCGR3A, CCL5, CCL11, IFNG, IL5
3extracellular spaceGO:0056156.9FGF2, GNLY, CCL5, CCL11, IFNG, IL4

Biological processes related to Folliculitis according to GeneCards/GeneDecks:

(show all 32)
idNameGO IDScoreTop Affiliating Genes
1eosinophil chemotaxisGO:04824510.3CCL5, CCL11
2positive regulation of isotype switching to IgG isotypesGO:04830410.2IFNG, IL4
3positive regulation of MHC class II biosynthetic processGO:04534810.2IL4, IFNG
4positive regulation of chemokine biosynthetic processGO:04508010.1IL4, IFNG
5positive regulation of JAK-STAT cascadeGO:04642710.1CCL5, IL5
6defense response to protozoanGO:04283210.1IFNG, IL4
7positive regulation of T cell differentiationGO:04558210.0IL4, IL2RA
8positive regulation of cerebellar granule cell precursor proliferationGO:02194010.0FGF2, EGF
9ERK1 and ERK2 cascadeGO:07037110.0EGF, CCL11
10response to virusGO:00961510.0IFNG, CCL11, CCL5
11positive regulation of cell adhesionGO:0457859.9IFNG, CCL5
12positive regulation of activated T cell proliferationGO:0421049.9IL4, IL2RA
13positive regulation of T cell proliferationGO:0421029.9CCL5, IFNG, IL4
14positive chemotaxisGO:0509189.9FGF2, CCL5
15positive regulation of catenin import into nucleusGO:0354139.8EGF, EGFR
16defense response to bacteriumGO:0427429.8DEFB4A, GNLY, IFNG
17positive regulation of cell migrationGO:0303359.7EGFR, CCL11, CCL5
18positive regulation of nitric oxide biosynthetic processGO:0454299.7EGFR, IFNG
19positive regulation of phosphorylationGO:0423279.6CCL5, EGFR, EGF
20positive regulation of B cell proliferationGO:0308909.4IL5, IL4
21negative regulation of epidermal growth factor receptor signaling pathwayGO:0420599.4EGFR, EGF
22phosphatidylinositol-mediated signalingGO:0480159.4FGF2, EGF, EGFR
23fibroblast growth factor receptor signaling pathwayGO:0085439.3FGF2, EGF, EGFR
24regulation of immune responseGO:0507769.3CD160, IL4, FCGR3A
25Fc-epsilon receptor signaling pathwayGO:0380959.3FGF2, EGF, EGFR
26epidermal growth factor receptor signaling pathwayGO:0071739.2EGFR, EGF, FGF2
27positive regulation of transcription, DNA-templatedGO:0458939.1IL4, IL5, EGF, FGF2
28cellular defense responseGO:0069689.1CD160, IL4, GNLY
29innate immune responseGO:0450879.0DEFB4A, FCGR3A, EGFR, EGF, FGF2
30cell surface receptor signaling pathwayGO:0071668.9EGFR, CD160, IL2RA, IFNG
31chemotaxisGO:0069358.7FGF2, IL4, CCL11, CCL5, PTGDR2, DEFB4A
32immune responseGO:0069558.4DEFB4A, PTGDR2, FCGR3A, CCL11, IL4, IL5

Molecular functions related to Folliculitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemoattractant activityGO:0420569.8FGF2, CCL5
2growth factor activityGO:0080838.8FGF2, EGF, IL5, IL4
3cytokine activityGO:0051258.8IFNG, IL4, IL5, FGF2

Products for genes affiliated with Folliculitis

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Sources for Folliculitis

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet