Food Allergy malady

MedlinePlus: Food allergy is an abnormal response to a food triggered by your body's immune system. allergic reactions to food can sometimes cause serious illness and death. tree nuts and peanuts are the leading causes of deadly allergic reactions called anaphylaxis. in adults, the foods that most often trigger allergic reactions include fish and shellfish, such as shrimp, lobster and crab peanuts tree nuts, such as walnuts eggs problem foods for children are eggs, milk (especially in infants and young children) and peanuts. sometimes a reaction to food is not an allergy. it is often a reaction called "food intolerance". your immune system does not cause the symptoms of food intolerance. however, these symptoms can look and feel like those of a food allergy. nih: national institute of allergy and infectious diseases²³

MalaCards: Food Allergy, also known as food hypersensitivity, is related to peanut allergic reaction and egg allergy. An important gene associated with Food Allergy is TMEM133 (transmembrane protein 133), and among its related pathways are Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response and Bacterial infections in CF airways. The drugs prednisone and prednisolone and the compounds budesonide and endotoxin have been mentioned in the context of this disorder. Affiliated tissues include small intestine, colon and liver, and related mouse phenotypes are renal/urinary system and endocrine/exocrine gland.

Disease Ontology: An allergy that is an abnormal response to a food, triggered by the body's immune system.⁶

Wikipedia: A food allergy is an adverse immune response to a food protein. They are distinct from other adverse...⁴⁴ more...

Aliases & Descriptions:

food allergy 6 8 23 43 food hypersensitivity 6

hypersensitivity 43 allergy food 32

Diseases related to food allergy by text searches and GeneDecks gene sharing:

(show top 50)    (show all 695)

id	Related Disease	Score	Top Affiliating Genes
1	peanut allergic reaction	31.4	IGHE, CSN1S1
2	egg allergy	31.2	IL4, IL5, IGHE
3	asthma	30.5	IL13, HNMT, TNF
4	extrinsic allergic alveolitis	29.9	CD14, FCER2, IL8, IGHE
5	eosinophilic gastroenteritis	29.0	IL5, IGES, IGHE, ALB, RNASE3, CSN1S1
6	protein-losing enteropathy	28.9	GCG, LCT, HNMT, TNF, ABP1
7	hypersensitivity reaction type iv disease	28.7	IL4, IGHE, IFNG
8	angioedema	28.5	CETP, MS4A2, IL5, IGHE, HRH1, HNMT
9	eosinophilic esophagitis	28.1	IL10, IL13, IL5, IGES, IGHE, IFNG
10	breast cancer	27.9	NAT2, IL10, IL8, IFNG, TNF, TGFB1
11	gastroenteritis	27.5	LCT, IL10, IL5, IL8, IGES, IGHE
12	allergic bronchopulmonary aspergillosis	27.1	IL4, IL5, IGES, IGHE
13	bullous pemphigoid	26.7	FCER2, IL13, IL5, IGHE, RNASE3
14	eczema	26.6	LGALS3, MS4A2, CD14, FOXP3, FCER2, IL10
15	mastocytosis	26.6	FCER2, IL13, IL5, IGHE, RNASE3
16	tuberculosis	26.5	IL10, IL4, IFNG, TNF, TLR4
17	septic shock	26.5	CD14, TNF
18	allergic conjunctivitis	26.4	IL13, IL4, IL5, IGHE, HRH1, RNASE3
19	tuberculoid leprosy	26.3	IL10, IFNG
20	allergic rhinitis	26.3	IL13, IL4, IL5, IGES, IGHE, HRH1
21	cough variant asthma	26.1	IL10, IL4, IL5, IGHE, RNASE3, ACE
22	rosacea	26.0	S100A8, CETP, IL8, TLR2
23	type 1 diabetes mellitus	25.8	GCG, CETP, ALB, ACE, CSN1S1
24	bagassosis	25.8	IL5, IL8, TNF
25	stevens-johnson syndrome	25.5	IL13, IL4, IL4R, ALB, TNF
26	multiple sclerosis	25.4	CD14, IL4R, APOE, IFNG
27	acrodermatitis	25.4	IFNG, ALB, TNF
28	irritable bowel syndrome	25.4	GCG, LCT, IL10, IL13, IL4, IL5
29	blindness	25.3	GCG, CHI3L1, CETP, IL10, IL4, IL5
30	omenn syndrome	25.2	IL10, IL4, IL5, IGHE, IFNG, TNF
31	vernal keratoconjunctivitis	25.2	IL13, IL4, IL5, IGES, IGHE, RNASE3
32	cryoglobulinemia	25.1	IL10, IL4, IFNG, TNF, TLR2
33	histiocytosis	24.9	IL10, IL4, IFNG, ALB, TNF
34	periodontitis	24.6	CD14, IL10, IL8, TNF, TLR2, TLR4
35	liver cirrhosis	24.6	GCG, CHI3L1, CD14, ALB, C1S, TLR2
36	urticaria	24.3	MS4A2, FCER2, IL10, IL13, IL4, IL8
37	periodontal disease	24.3	NAT2, S100A8, CD14, IL8, TNF, TLR2
38	idiopathic pulmonary fibrosis	24.3	IL13, IL8, IFNG, TGFB1
39	immunodeficiency	24.2	LGALS9, S1PR1, FOXP3, IL10, IL13, IL4
40	hyperthyroidism	24.1	IL13, IL4, APOE, IGES, IGHE, IFNG
41	hypersensitivity reaction type ii disease	23.7	FOXP3, IL10, IL13, IL4, IL5, IL8
42	skin disease	23.6	S100A8, FCER2, IL10, IL13, IL4, IL5
43	celiac disease	23.5	LCT, CD14, FOXP3, IL10, IL4, IL4R
44	acne	23.4	IL4, IL8, APOE, IFNG, TNF, TLR2
45	sickle cell disease	23.3	IL8, APOE, IFNG, ALB, TNF, DARC
46	alpha 1-antitrypsin deficiency	23.2	CD14, IL10, IL8, IGES, IGHE, IFNG
47	neuritis	23.0	S100A8, S1PR1, IL10, IL4, IL5, APOE
48	systemic lupus erythematosus	23.0	NAT2, CHI3L1, S100A8, FCER2, IL10, IL4
49	gout	22.9	S1PR1, IL4, IL8, APOE, ALB, TNF
50	cerebral infarction	22.8	IL10, IL4, APOE, ALB, TNF, ACE

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 cromolyn, cromolyn sodium, methylprednisolone, methylprednisolone acetate, methylprednisolone sodium succinate, prednisolone, prednisolone acetate, prednisolone acetate pwdr [va product], prednisolone pwdr [va product], prednisolone sodium phosphate, prednisolone tebutate, prednisone, prednisone pwdr [va product]

MalaCards organs/tissues related to food allergy:

²²

MGI Mouse Phenotypes related to food allergy:

²⁵ (show all 16)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	renal/urinary system phenotype	MP:0005367	10.1	APOE
2	endocrine/exocrine gland phenotype	MP:0005379	9.9	CSN3, TLR2, IFNG
3	respiratory system phenotype	MP:0005388	9.9	STAT6, APOE, CD14
4	skeleton phenotype	MP:0005390	9.6	PFAS, DARC, GPR126, CD14, LGALS9, LGALS3
5	liver/biliary system phenotype	MP:0005370	9.5	TLR4, TLR2, HRH1, IFNG, FAIM
6	hematopoietic system phenotype	MP:0005397	9.1	FAIM, CCR9, IGHE, STAT6, EPX, IL5
7	immune system phenotype	MP:0005387	8.8	LGALS3, TLR4, DARC, TNF, IFNG, CCR9
8	integument phenotype	MP:0010771	8.4	CSN3, CSN1S1, STAT6, TLR4, TLR2, IFNG
9	digestive/alimentary phenotype	MP:0005381	8.0	TGFB1, TLR2, IFNG, CCR9, APOE, FCER2
10	growth/size phenotype	MP:0005378	7.4	STAT6, TLR4, ACE, HRH1, GPR126, APOE
11	reproductive system phenotype	MP:0005389	7.2	CSN3, CSN1S1, STAT6, TGFB1, TLR4, TNF
12	tumorigenesis	MP:0002006	7.1	TGFB1, TLR4, TLR2, ACE, TNF, IFNG
13	adipose tissue phenotype	MP:0005375	7.0	TGFB1, TLR4, TLR2, ACE, TNF, HRH1
14	mortality/aging	MP:0010768	6.9	GPR126, IFNG, TXN, ACE, TLR2, TLR4
15	homeostasis/metabolism phenotype	MP:0005376	5.9	IGHE, ALB, HRH1, DARC, TLR2, TLR4
16	cellular phenotype	MP:0005384	4.6	GPR126, IFNG, HRH1, TXN, TNF, ACE

Articles related to food allergy:

(show top 50)    (show all 100)

id	Title	Authors	Year	Affiliating Genes
1	Increased serum YKL-40: a new potential marker for ai rway allergic responses in adult patients with food allergy. (21496058)	Kim T.W.... Min K.U.	2011	CHI3L1
2	Intestinal epithelial cells express galectin-9 in pat ients with food allergy that plays a critical role in sustaining allergic statu s in mouse intestine. (21426359)	Chen X.... Yang P.C.	2011	LGALS9
3	Eczema and food allergy in an Italian pediatric cohor t: no association with TLR-2 and TLR-4 polymorphisms. (20646366)	Galli E.... Corleto V.D.	2010	TLR2, TLR4
4	The role of immunoglobulin E-binding epitopes in the characterization of food allergy. (19568005)	Lin J.... Sampson H.A.	2009	IGHE
5	Food allergy in AlergolA^gica-2005. (19530417)	FernA!ndez Rivas M.	2009	IGHE
6	Food allergy and food sensitization in early childhoo d: results from the DARC cohort. (19220211)	Eller E.... Bindslev-Jensen C.	2009	DARC
7	Treatment and management of food allergy (19899529)	Urisu A.	2009	HRH1
8	Anti-acids lead to immunological and morphological ch anges in the intestine of BALB/c mice similar to human food allergy. (18524557)	Pali-SchAPll I.... Fehrenbach H.	2008	IGHE
9	Is caesarean delivery associated with sensitization to food allergens and IgE-mediated food allergy: a systematic review. (19076564)	Koplin J.... Dharmage S.	2008	IGHE
10	Helicobacter pylori as a protective factor against food allergy. (18758415)	Konturek P.C.... Raithel M.	2008	IL4, RNASE3, IGHE
11	IL-10 gene polymorphism, but not TGF-beta1 gene polymorphisms, is associated with food allergy in a Japanese population. (18208460)	Campos Alberto E.J.... Kohno Y.	2008	TGFB1, IL10
12	Asthma and food allergy. (18043270)	Ozol D.... Mete E.	2008	IGHE
13	Rice: another potential cause of food allergy in patients sensitized to lipid transfer protein. (17192718)	Asero R.... Mistrello G.	2007	CETP
14	Increased number of CCR4-positive cells in the duodenum of ovalbumin-induced food allergy model Nc/jic mice and antiallergic activity of fructooligosaccharides. (17384533)	Fujitani S.... Itabashi K.	2007	CNOT6
15	Lipid transfer protein allergy: primary food allergy or pollen/food syndrome in some cases. (17489047)	Zuidmeer L.... Van Ree R.	2007	CETP
16	Food allergy to proteins. (17245088)	Nowak-Wegrzyn A.	2007	IGHE
17	Thioredoxin and food allergy. (17141854)	Buchanan B.B.... Frick O.L.	2007	TXN
18	Influence of the allelic variants encoded at the Gli-B1 locus, responsible for a major allergen of wheat, on IgE reactivity for patients suffering from food allergy to wheat. (17263477)	Denery-Papini S.... Moneret-Vautrin D.A.	2007	IGHE
19	Influence of SNPs in cytokine-related genes on the severity of food allergy and atopic eczema in children. (17121586)	Negoro T.... Tobe T.	2006	STAT6, IL4, IL10
20	Prevalence of elevated total IgE and food allergies in a consecutive series of ENT pediatric patients. (16564375)	Bhombal S.... Bauer S.M.	2006	IGHE
21	Gastrointestinal manifestations of food allergies in pediatric patients. (16207693)	Garcia-Careaga M.... Kerner J.A.	2005	IGHE
22	Identification of IgE-binding epitopes on gliadins for patients with food allergy to wheat. (15876313)	Battais F.... Denery-Papini S.	2005	IGHE
23	Utility of the ratio of food-specific IgE/total IgE in predicting symptomatic food allergy in children. (15969684)	Mehl A.... Niggemann B.	2005	IGHE
24	Molecular basis of pollen-related food allergy: identification of a second cross-reactive IgE epitope on Pru av 1, the major cherry (Prunus avium) allergen. (15330760)	Wiche R.... Vieths S.	2005	IGHE
25	The diagnostic value of skin prick testing in children with food allergy. (15482519)	Hill D.J.... Hosking C.S.	2004	IGHE
26	Both catabolic pathways of histamine via histamine-N-methyltransferase and diamine oxidase are diminished in the colonic mucosa of patients with food allergy. (15054605)	Kuefner M.A.... Raithel M.	2004	HNMT, ABP1
27	Specific IgE levels do not indicate persistence or tr ansience of food allergy in children with atopic dermatitis. (15301297)	Niggemann B.... Wahn U.	2004	IGHE
28	Clinical role of lipid transfer proteins in food allergy. (15672475)	Pastorello E.A.... Robino A.M.	2004	CETP
29	T lymphocytes and food allergy. (15508177)	Bohle B.	2004	IGHE
30	Antacid medication inhibits digestion of dietary proteins and causes food allergy: a fish allergy model in BALB/c mice. (13679824)	Untersmayr E.... Jensen-Jarolim E.	2003	IGHE
31	The -159 C-->T polymorphism of CD14 is associated with nonatopic asthma and food allergy. (12897754)	Woo J.G.... Hershey G.K.	2003	CD14
32	Eosinophil cationic protein in serum of children with food allergy (12712820)	Maciorkowska E.... Kaczmarski M.	2003	RNASE3
33	Glucagon-like peptide-2-enhanced barrier function reduces pathophysiology in a model of food allergy. (12736145)	Cameron H.L.... Perdue M.H.	2003	GCG
34	Immunoglobulin E and eosinophilic cationic protein in segmental lavage fluid of the small and large bowel identify patients with food allergy. (11232698)	Schwab D.... Hahn E.G.	2001	RNASE3, IGHE
35	Skin manifestations in food allergy. (11298021)	Werfel T.	2001	IGHE
36	Genotype of N-acetyltransferase 2 (NAT2) polymorphism in children with immunoglobulin E-mediated food allergy. (11372006)	Gawronska-Szklarz B.... Wrzesniewska J.	2001	NAT2
37	Severe food allergies by skin contact. (11379811)	Tan B.M.... Bahna S.L.	2001	IGHE
38	Evaluating the profile of selected cytokines in patients with food allergy and chronic gastritis. (11208468)	Bartuzi Z.... Sinkiewicz W.	2000	IL8, IL4, IL5
39	Quantitative IgE inhibition experiments with purified recombinant allergens indicate pollen-derived allergens as the sensitizing agents responsible for many forms of plant food allergy. (10629461)	Kazemi-Shirazi L.... Valenta R.	2000	IGHE
40	Food allergy and Helicobacter pylori infection. (10379477)	Figura N.... Rottoli P.	1999	IGHE
41	Pollen-related food allergy: cloning and immunological analysis of isoforms and mutants of Mal d 1, the major apple allergen, and Bet v 1, the major birch pollen allergen. (10502033)	Son D.Y.... Vieths S.	1999	IGHE
42	Eosinophil protein X and eosinophil cationic protein as indicators of intestinal inflammation in infants with atopic eczema and food allergy. (10520078)	Majamaa H.... Miettinen A.	1999	EPX, RNASE3
43	Positive association between Helicobacter pylori infection and food allergy in children. (9867089)	Corrado G.... Cardi E.	1998	S100A8
44	Idiopathic thrombocytopenic purpura and food allergy : a study on possible correlations (10335541)	Massolo F.... Venuta A.	1998	CSN1S1
45	Probiotics: a novel approach in the management of food allergy. (9042042)	Majamaa H.... Isolauri E.	1997	RNASE3
46	Specific IgE against inhaled allergens in dystreptic children with food allergy (9156886)	Bujniewicz E.... Krauze M.	1996	IGHE
47	Possible induction of food allergy during mite immunotherapy. (8738516)	Van Ree R.... Bonifazi F.	1996	IGHE
48	IgE levels in faecal extracts of patients with food allergy. (1285567)	Sasai K.... Yabuta K.	1992	IGHE
49	Immunologic reactivity in patients with food allergy (1774922)	Nogaller A.M.	1991	IGHE
50	Food allergy and the potential allergenicity-antigenicity of microparticulated egg and cow's milk proteins. (2212400)	Sampson H.A.... Cooke S.K.	1990	IGHE

Genes related to food allergy according to GeneCards:

(show all 49)

id	Symbol	Description	Score	GeneCards Section Context
1	TMEM133	transmembrane protein 133	11.0
2	IGHE	immunoglobulin heavy constant epsilon	11.0	Publications
3	TMEM37	transmembrane protein 37	11.0	Publications
4	CSN3	casein kappa	11.0	Publications
5	FAIM	Fas apoptotic inhibitory molecule	11.0
6	IGES	immunoglobulin E concentration, serum	11.0	Publications
7	ABP1	amiloride binding protein 1 (amine oxidase (copper-containing))	11.0	Publications
8	RNASE3	ribonuclease, RNase A family, 3	11.0	Publications
9	LGALS9	lectin, galactoside-binding, soluble, 9	11.0	Publications
10	MS4A2	membrane-spanning 4-domains, subfamily A, member 2	11.0	Publications
11	EPX	eosinophil peroxidase	11.0	Publications
12	C1S	complement component 1, s subcomponent	11.0	Publications
13	S1PR1	sphingosine-1-phosphate receptor 1	11.0	Publications
14	DARC	Duffy blood group, chemokine receptor	11.0	Publications
15	HNMT	histamine N-methyltransferase	11.0	Publications
16	CHI3L1	chitinase 3-like 1 (cartilage glycoprotein-39)	11.0	Publications
17	CCR9	chemokine (C-C motif) receptor 9	11.0	Publications
18	PFAS	phosphoribosylformylglycinamidine synthase	11.0
19	CETP	cholesteryl ester transfer protein, plasma	11.0	Publications
20	AKR1E2	aldo-keto reductase family 1, member E2	11.0
21	EHF	ets homologous factor	11.0
22	S100A8	S100 calcium binding protein A8	11.0	Publications
23	STAT6	signal transducer and activator of transcription 6, interleukin-4 induced	11.0	Publications
24	FOXP3	forkhead box P3	11.0	Publications
25	CNOT6	CCR4-NOT transcription complex, subunit 6	11.0	Publications
26	FCER2	Fc fragment of IgE, low affinity II, receptor for (CD23)	11.0	Publications
27	CSN1S1	casein alpha s1	11.0	Publications
28	CD14	CD14 molecule	11.0	Publications
29	LGALS3	lectin, galactoside-binding, soluble, 3	11.0	Publications
30	GCG	glucagon	11.0	Publications
31	TXN	thioredoxin	11.0	Publications
32	LCT	lactase	11.0
33	IL5	interleukin 5 (colony-stimulating factor, eosinophil)	11.0	Publications
34	HRH1	histamine receptor H1	11.0	Publications
35	GPR126	G protein-coupled receptor 126	11.0
36	IL4R	interleukin 4 receptor	11.0	Publications
37	IL4	interleukin 4	11.0	Publications
38	TLR2	toll-like receptor 2	11.0	Publications
39	TLR4	toll-like receptor 4	11.0	Publications
40	NAT2	N-acetyltransferase 2 (arylamine N-acetyltransferase)	11.0	Publications
41	IL10	interleukin 10	11.0	Publications
42	IL13	interleukin 13	11.0	Publications
43	IFNG	interferon, gamma	11.0	Publications
44	ACE	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	11.0	Publications
45	ALB	albumin	11.0	Publications
46	APOE	apolipoprotein E	11.0	Publications
47	IL8	interleukin 8	11.0	Publications
48	TGFB1	transforming growth factor, beta 1	11.0	Publications
49	TNF	tumor necrosis factor	11.0	Publications

Pathways related to food allergy according to GeneDecks:

(show top 50)    (show all 61)

id	Pathway	Score	Top Affiliating Genes
1	Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response10	10.7	CD14
2	Bacterial infections in CF airways41	10.6	TLR2
3	OX40 Pathway36	10.1	IL5, IL4, IL13
4	Immune response IL-4 signaling pathway10	9.9	STAT6, IGHE, IL4R, IL4, FCER2
5	Immune response_IL-4 signaling pathway41	9.8	STAT6, IGHE, IL4R, IL4, FCER2
6	NFAT Signaling and Lymphocyte Interactions36	9.8	IL5, IL4, IL13, FCER2
7	Fc epsilon RI signaling pathway20	9.7	MS4A2, IL4, TNF
8	IL-4 Signaling Pathways37	9.5	STAT6, IL4R, IL4
9	IL-4 Signaling and its Primary Biological Effects in Different Immune Cell Types37	9.4	STAT6, TGFB1, IL4R, IL4
10	Jak-STAT signaling pathway20	9.4	STAT6, IL5, IL4R, IL4, IL13, IL10
11	Akt Signaling36	9.3	TNF, IL4R, IL4, IL10
12	Hematopoietic cell lineage20	9.3	TNF, IL5, IL4R, IL4, FCER2, CD14
13	Immune response_TLR signaling pathways41	9.2	TLR4, TLR2, IL8, IL4, CD14
14	Allograft rejection20	9.2	TNF, IFNG, IL5, IL4, IL10
15	THC Differentiation Pathway36	9.2	TNF, IFNG, IL4R, IL4, IL10
16	Immune response_Bacterial infections in normal airways41	9.1	TLR4, TLR2, IFNG, IL8, CD14
17	Intestinal immune network for IgA production20	9.1	TGFB1, CCR9, IL5, IL4, IL10
18	IL-10 Pathway36	9.1	CD14, IL10, TNF, TLR4
19	Th1 Differentiation37	9.1	TLR4, TLR2, TNF, IFNG, IL10
20	PGC1Alpha Pathway36	9.1	IL8, IL5, IL4R, IL4, IL13
21	IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types37	9.0	TGFB1, IL5, IL4R, IL4, IL13
22	IL-2 Signaling and its Primary Biological Effects in Different Immune Cell Types37	9.0	TGFB1, TNF, IL10, FOXP3
23	Asthma20	9.0	MS4A2, EPX, RNASE3, TNF, IL5, IL4
24	Immune response_MIF in innate immunity response41	8.9	TLR4, TNF, IFNG, IL8, CD14
25	Immune response MIF in innate immunity response10	8.9	TLR4, TNF, IFNG, IL8, CD14
26	Pertussis20	8.9	TLR4, C1S, TNF, IL8, IL10, CD14
27	Amoebiasis20	8.7	TGFB1, TLR4, TLR2, IL8, CD14
28	Cytokine production by Th17 cells in CF (Mouse model)41	8.7	TGFB1, TLR4, IL8, FOXP3, CD14
29	IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types37	8.7	TGFB1, TLR4, TLR2, IFNG, IL4R, IL4
30	Toll-like receptor signaling pathway20	8.6	CD14, IL8, TNF, TLR2, TLR4
31	all-trans-Retinoic Acid Signaling in Brain36	8.3	TNF, IL8, IL5, IL4, IL13, IL10
32	PEDF Induced Signaling36	8.3	TNF, IL8, IL5, IL4, IL13, IL10
33	Cytokine Network36	8.3	TNF, IFNG, IL8, IL5, IL4, IL13
34	STAT3 Pathway36	8.2	TNF, CCR9, IL8, IL5, IL4R, IL4
35	MIF Mediated Glucocorticoid Regulation36	8.2	TLR4, TNF, IL8, IL5, IL4, IL13
36	MIF Regulation of Innate Immune Cells36	8.2	TLR4, TNF, IL8, IL5, IL4, IL13
37	Toxoplasmosis20	8.1	TGFB1, TLR4, TLR2, TNF, IFNG, IL10
38	Leishmaniasis20	8.1	TGFB1, TLR4, TLR2, TNF, IFNG, IL4
39	Tuberculosis20	8.0	TGFB1, TLR4, TLR2, TNF, IFNG, IL10
40	Rheumatoid arthritis20	8.0	TGFB1, TLR4, TLR2, TNF, IFNG, IL8
41	Glucocorticoid Receptor Signaling36	8.0	TGFB1, IL8, IL5, IL4R, IL4, IL13
42	TGF-Beta Pathway36	7.7	TGFB1, IL8, IL5, IL4R, IL4, IL13
43	Malaria20	7.6	TGFB1, TLR4, TLR2, DARC, TNF, IFNG
44	JAK-STAT Pathway36	7.5	STAT6, TGFB1, IFNG, IL8, IL5, IL4R
45	MAPK Family Pathway36	7.3	TGFB1, TNF, IL8, IL5, IL4R, IL4
46	Antioxidant Action of Vitamin-C36	7.3	TGFB1, TNF, CCR9, IL8, IL5, IL4R
47	Chagas disease (American trypanosomiasis)20	7.3	TGFB1, TLR4, TLR2, ACE, TNF, IFNG
48	p38 Signaling36	7.3	TGFB1, TNF, CCR9, IL8, IL5, IL4R
49	Cytokine-cytokine receptor interaction20	7.1	TGFB1, TNF, IFNG, CCR9, IL8, IL5
50	Tec Kinases Signaling36	6.8	STAT6, TGFB1, TLR4, TLR2, TNF, CCR9

Compounds related to food allergy according to GeneDecks:

(show top 50)    (show all 224)

id	Compound	Score	Top Affiliating Genes
1	budesonide32 42 9 9	13.6	EPX, RNASE3, IGHE
2	endotoxin32	10.3	ABP1, HRH1, S100A8, CD14
3	ionomycin32	10.2	STAT6, IL5, FCER2
4	omalizumab32 9 9	11.7	IGHE, IL5, IL4, MS4A2, IL13
5	ketotifen32 9 9	11.6	HRH1, RNASE3, ABP1, EPX, IL5, IGHE
6	cetirizine32 9 18 9	12.5	IL8, HRH1, RNASE3, EPX, IL5, IGHE
7	carbohydrates32	9.4	LGALS3, LCT, CETP, CD14, TXN, RNASE3
8	calcitriol32 42 9 18 9	13.3	CD14, FCER2, IL13, ALB, TLR2, S100A8
9	praziquantel32 9 9	11.2	IL10, RNASE3, IGHE, IL13, IL4, IL5
10	nedocromil sodium32	9.2	RNASE3, FCER2, IL8, IL5, IL4, IGHE
11	sb 20358032 42	10.2	FCER2, IL13, GCG, IFNG, STAT6, TNF
12	pge232	9.1	CD14, FOXP3, FCER2, IL13, IL5, TLR2
13	salbutamol32 34 9 18 9	12.9	FCER2, RNASE3, IGHE, IL8, IL10, EPX
14	montelukast32 34 9 9	11.9	IL13, IL5, IL8, IGHE, RNASE3, IL4
15	heparin32 9 18 9	11.8	LGALS3, LCT, CETP, APOE, ALB, RNASE3
16	vegf32	8.6	LGALS3, TXN, RNASE3, TGFB1, CD14, S1PR1
17	salmeterol32 42 9 9	11.6	IL13, IL4, EPX, RNASE3, IL8, IL5
18	polyinosinic-polycytidylic acid32	8.5	IL4, IL10, IL5, IFNG, TLR4, TLR2
19	creatinine32	8.3	IGHE, ACE, RNASE3, TXN, GCG, S100A8
20	fluticasone propionate32 42 9 9	11.2	IL4, IL5, IL8, IFNG, IGHE, TNF
21	cysteine32	8.2	CD14, IFNG, S100A8, LGALS3, NAT2, GCG
22	methacholine32 9 9	10.2	IGHE, IGES, IL5, IL8, IL4, IL13
23	il-1232	8.2	IL8, TNF, IL10, IL13, IFNG, IL4
24	rolipram32 42	9.1	IFNG, TNF, EPX, IL5, IL4, IL13
25	fmlp32	8.1	ABP1, IL5, IL13, FCER2, RNASE3, CD14
26	prednisolone32 9 9	10.0	IL13, IL10, EPX, CSN1S1, RNASE3, ALB
27	polymyxin b32	8.0	IFNG, TNF, TLR2, IL8, IL4, IL10
28	tarc32	7.8	IL13, IL10, IL5, IL4, TNF, IFNG
29	hydrocortisone32 9 9	9.6	IL5, IL4, IL13, IL10, FCER2, CD14
30	aspirin32 34 18	9.6	APOE, TGFB1, RNASE3, C1S, ACE, HRH1
31	rantes32	7.5	CD14, IL13, IL4, IL4R, IL5, IFNG
32	arginine32	7.4	IFNG, TXN, C1S, ABP1, TLR2, CSN1S1
33	thyroxine32 18	8.3	ALB, IL10, TXN, TGFB1, CSN1S1, IGHE
34	gm-csf32	7.3	IL8, IFNG, TNF, TGFB1, IL5, IL4
35	histamine32 18	8.1	EPX, CSN1S1, STAT6, TLR4, TLR2, ABP1
36	glutamine32	7.1	GCG, IL5, ABP1, TXN, IGHE, APOE
37	vitamin d32	7.1	LGALS3, CSN1S1, CD14, IL10, IL5, TGFB1
38	ly29400232	7.1	GCG, S1PR1, IL13, IL4, CSN1S1, TGFB1
39	allergens32	7.1	IGES, IGHE, IFNG, HRH1, RNASE3, TLR4
40	tacrolimus32 34 9 9	9.9	IL10, IL13, IL4, IL5, IFNG, TGFB1
41	il 1032	6.6	IFNG, TNF, TLR2, TLR4, TGFB1, IL8
42	indomethacin32 9 9	8.5	TNF, HRH1, ALB, IFNG, TGFB1, APOE
43	lactate32	6.4	TXN, ALB, IGHE, IGES, IL8, IL13
44	retinoic acid32 42 18	8.3	LGALS3, S100A8, CSN1S1, CETP, STAT6, TGFB1
45	alanine32	6.3	ALB, IL13, TLR2, DARC, TXN, HRH1
46	actinomycin d32	6.1	STAT6, TGFB1, TLR4, TLR2, TNF, IL4R
47	nitric oxide32 9 18 9	9.0	IFNG, IGES, IL8, IL13, IL10, FCER2
48	cycloheximide32	5.1	IL8, APOE, IGHE, IFNG, TXN, TNF
49	dexamethasone32 42 34 9 9	9.1	EPX, IL13, IL10, FCER2, CD14, S100A8
50	cyclosporin a32 42	6.0	RNASE3, CD14, CETP, FOXP3, IL10, IL13

Cellular components related to food allergy according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	external side of plasma membrane	GO:009897	7.4	TLR4, TLR2, ACE, TNF, IFNG, IL4
2	extracellular region	GO:005576	5.5	IFNG, ALB, TXN, RNASE3, C1S, TGFB1
3	extracellular space	GO:005615	4.7	GCG, TGFB1, ACE, ABP1, TNF, ALB

Biological processes related to food allergy according to GeneDecks:

(show all 36)

id	Name	GO ID	Score	Top Affiliating Genes
1	cellular response to histamine	GO:071420	10.3	HRH1, ABP1
2	regulation of isotype switching	GO:045191	10.2	IL4, IL10
3	cellular response to lipoteichoic acid	GO:071223	10.1	CD14, TLR2, TLR4
4	positive regulation of nitric-oxide synthase biosynthetic process	GO:051770	10.1	TLR4, TLR2, FCER2
5	positive regulation of killing of cells of other organism	GO:051712	9.9	IFNG, FCER2
6	negative regulation of interleukin-17 production	GO:032700	9.9	TLR4, TLR2, IFNG
7	negative regulation of interferon-gamma production	GO:032689	9.9	FOXP3, IL10, TLR4
8	positive regulation of vitamin D biosynthetic process	GO:060557	9.9	TNF, IFNG
9	positive regulation of podosome assembly	GO:071803	9.9	IL5, TNF
10	positive regulation of interleukin-12 production	GO:032735	9.8	TLR4, TLR2, IFNG
11	positive regulation of tumor necrosis factor production	GO:032760	9.7	TLR4, TLR2, IFNG, CD14
12	positive regulation of B cell proliferation	GO:030890	9.7	TLR4, IL5, IL4, IL13
13	positive regulation of chemokine production	GO:032722	9.7	TLR4, TLR2, TNF
14	positive regulation of NF-kappaB import into nucleus	GO:042346	9.7	TLR4, TLR2, TNF
15	positive regulation of chemokine biosynthetic process	GO:045080	9.7	TNF, IFNG, IL4
16	negative regulation of interleukin-6 production	GO:032715	9.7	TLR4, TNF, IL10
17	positive regulation of MHC class II biosynthetic process	GO:045348	9.7	TLR4, IFNG, IL4, IL10
18	positive regulation of peptidyl-threonine phosphorylation	GO:010800	9.7	TGFB1, CHI3L1, GCG
19	positive regulation of calcidiol 1-monooxygenase activity	GO:060559	9.6	TNF, IFNG
20	response to ethanol	GO:045471	9.6	TLR4, IL4, IL13, S100A8, LCT
21	positive regulation of cytokine secretion	GO:050715	9.6	TLR2, TNF, IL10, CD14
22	receptor biosynthetic process	GO:032800	9.5	TNF, IL10
23	mononuclear cell proliferation	GO:032943	9.5	TGFB1, ACE
24	negative regulation of growth of symbiont in host	GO:044130	9.4	TLR2, TNF, IFNG, IL10
25	positive regulation of membrane protein ectodomain proteolysis	GO:051044	9.4	TNF, IFNG, APOE
26	positive regulation of sequence-specific DNA binding transcription factor activity	GO:051091	9.4	TNF, IL5, IL4, IL10
27	positive regulation of ERK1 and ERK2 cascade	GO:070374	9.4	GCG, CHI3L1, TNF, TLR4
28	positive regulation of nitric oxide biosynthetic process	GO:045429	9.2	TLR4, TLR2, TNF, HRH1, IFNG
29	cellular response to lipopolysaccharide	GO:071222	9.1	TLR4, IFNG, IL8, IL10, CD14
30	protein import into nucleus, translocation	GO:000060	9.0	IFNG, TNF, TGFB1
31	lipopolysaccharide-mediated signaling pathway	GO:031663	9.0	TGFB1, TLR4, TLR2, TNF
32	negative regulation of T cell proliferation	GO:042130	8.9	TGFB1, IL10, FOXP3
33	G-protein coupled receptor signaling pathway	GO:007186	8.8	HRH1, GPR126, CCR9, APOE, IL8, MS4A2
34	immune response	GO:006955	8.5	TLR4, TLR2, IGHE, CCR9, IL8, IL5
35	response to drug	GO:042493	8.2	TGFB1, ABP1, TNF, IFNG, IL4, IL10
36	inflammatory response	GO:006954	6.9	CHI3L1, TGFB1, TLR2, DARC, TNF, HRH1

Molecular functions related to food allergy according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	lipoteichoic acid binding	GO:070891	10.0	CD14, TLR2
2	IgE binding	GO:019863	9.9	LGALS3, MS4A2, FCER2
3	cytokine activity	GO:005125	8.1	TNF, IFNG, IL5, IL4, IL13, IL10