MCID: FDL002
MIFTS: 60

Food Allergy malady

Immune diseases category

Summaries for Food Allergy

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Sources:
8Disease Ontology, 33MedlinePlus, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Food allergy is an abnormal response to a food triggered by your body's immune system. in adults, the foods that most often trigger allergic reactions include fish, shellfish, peanuts, and tree nuts, such as walnuts. problem foods for children can include eggs, milk, peanuts, tree nuts, soy, and wheat. symptoms of food allergy include itching or swelling in your mouth vomiting, diarrhea, or abdominal cramps and pain hives or eczema tightening of the throat and trouble breathing drop in blood pressure your health care provider may use a detailed history, elimination diet, and skin and blood tests to diagnose a food allergy. when you have food allergies, you must be prepared to treat an accidental exposure. wear a medical alert bracelet or necklace, and carry an auto-injector device containing epinephrine (adrenaline). you can only prevent the symptoms of food allergy by avoiding the food. after you and your health care provider have identified the foods to which you are sensitive, you must remove them from your diet. nih: national institute of allergy and infectious diseases

MalaCards: Food Allergy, also known as food hypersensitivity, is related to dermatitis and atopic dermatitis. An important gene associated with Food Allergy is RNASE3 (ribonuclease, RNase A family, 3), and among its related pathways are IL4-mediated signaling events and Allograft rejection. The drugs cromolyn sodium and cromolyn and the compounds pge2 and omalizumab have been mentioned in the context of this disorder. Affiliated tissues include testes, skin and t cells, and related mouse phenotypes are hematopoietic system and immune system.

Disease Ontology:8 An allergy that is an abnormal response to a food, triggered by the body's immune system.

Wikipedia:63 A food allergy is an adverse immune response to a food protein. They are distinct from other adverse... more...

Aliases & Classifications for Food Allergy

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 56SNOMED-CT, 34MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Immune diseases


Aliases & Descriptions:

food allergy 8 10 33 60
food hypersensitivity 8
hypersensitivity 60
allergy food 44


External Ids:

Disease Ontology8 DOID:3044
MeSH34 D005512

Related Diseases for Food Allergy

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Food Allergy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 481)
idRelated DiseaseScoreTop Affiliating Genes
1dermatitis31.0FOXP3, IGHE, IL5, MS4A2
2atopic dermatitis31.0CSN1S1, STAT6, RNASE3
3vasculitis31.0CD14
4asthma30.9IL5, RNASE3, EPX, IGHE
5egg allergy30.9IGHE, IL5
6eosinophilic esophagitis30.7IL5
7esophagitis30.7IL5, S100A8
8extrinsic allergic alveolitis30.7IGHE, CD14
9eosinophilic gastroenteritis30.5CSN1S1, IGHE, IL5
10pneumonia30.5S100A8, EPX, IL5
11skin disease30.4S100A8, STAT6, IGHE, RNASE3, IL5
12arthritis30.4S100A8, CSN1S1, FOXP3, STAT6
13peanut allergic reaction30.4IGHE, CSN1S1
14allergic asthma30.4STAT6, IGHE, CD14, EPX, RNASE3, IL5
15leukemia30.4S100A8, FOXP3, CD14, EPX, RNASE3
16celiac disease30.3CSN1S1, CCR9
17angioedema30.3IGHE, RNASE3, IL5
18gastritis30.3S100A8
19rhinitis30.3IGHE, EPX, RNASE3, IL5, MS4A2
20eosinophilia30.2FOXP3, STAT6, IGHE, CD14, EPX, RNASE3
21rheumatoid arthritis30.2CCR9, S100A8, CSN1S1, FOXP3, STAT6, CD14
22sarcoidosis30.2CD14
23ischemia30.1EPX, CD14
24eosinophilic pneumonia30.1IGHE, RNASE3, IL5
25allergic bronchopulmonary aspergillosis30.1IGHE, IL5
26conjunctivitis30.1MS4A2, RNASE3, IGHE
27diarrhea30.0CSN1S1
28nephrotic syndrome30.0CETP, CD14
29anisakiasis30.0RNASE3, IGHE
30gastroesophageal reflux disease30.0S100A8, CSN1S1
31allergic rhinitis30.0IL5, RNASE3, EPX, IGHE
32urticaria30.0RNASE3, IGHE, CSN1S1
33contact dermatitis30.0IL5, IGHE
34uveitis30.0CD14
35duodenitis30.0S100A8
36allergic conjunctivitis30.0IL5, RNASE3, IGHE
37hypersensitivity reaction type ii disease30.0S100A8, CSN3, CSN1S1, FOXP3, STAT6, IL5
38churg-strauss syndrome29.9IL5, RNASE3
39bullous pemphigoid29.9IGHE, RNASE3, IL5
40diabetes mellitus29.9CSN1S1, FOXP3, CD14, CETP
41tuberculosis29.9EPX
42peritonitis29.8CD14
43cystic fibrosis29.8S100A8, RNASE3
44bronchiolitis29.8IL5, RNASE3, IGHE
45ulcerative colitis29.8CSN1S1, STAT6, CD14, EPX, RNASE3
46atopy29.8CSN1S1, STAT6, IGHE, CD14, EPX, RNASE3
47wegener's granulomatosis29.8CD14
48multiple sclerosis29.8IL5, FOXP3, S100A8, S1PR1
49hepatitis b29.5CSN1S1
50otitis media29.5IGHE, CD14, RNASE3

Graphical network of the top 20 diseases related to Food Allergy:



Diseases related to food allergy

Clinical Features for Food Allergy

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Drugs & Therapeutics for Food Allergy

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Genetic Tests for Food Allergy

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Anatomical Context for Food Allergy

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32MalaCards
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MalaCards organs/tissues related to Food Allergy:

32
Testes, Skin, T cells, Liver, B cells, Small intestine, Breast, Colon, Endothelial

Animal Models for Food Allergy or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Food Allergy:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053979.8S1PR1, FOXP3, FAIM, STAT6, IGHE, EPX
2MP:00053879.3LGALS9, CCR9, S1PR1, FOXP3, FAIM, STAT6

Publications for Food Allergy

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Sources:
50PubMed
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Articles related to Food Allergy:

(show top 50)    (show all 641)
idTitleAuthorsYear
1
The management of food allergy in Indonesia. (23403763)
2013
2
Paediatric anaphylaxis in a Singaporean children cohort: changing food allergy triggers over time. (23403810)
2013
3
The diagnosis of food allergy: a systematic review and meta-analysis. (24329961)
2013
4
Food Allergy and Increased Asthma Morbidity in a School-Based Inner-City Asthma Study. (24058900)
2013
5
Perceptions of precautionary labelling among parents of children with food allergy and anaphylaxis. (23919711)
2013
6
Probiotics and prebiotics in preventing food allergy and eczema. (23594506)
2013
7
Macrophages in food allergy: an enigma. (23911419)
2013
8
Use of animal models to investigate major allergens associated with food allergy. (23690797)
2013
9
Immunotherapy - risk/benefit in food allergy. (24112425)
2013
10
The acute and long-term management of food allergy: protocol for a rapid systematic review. (23547741)
2013
11
Epidemiology of food allergy in Latin America. (24207003)
2013
12
Vaccines and immunomodulatory therapies for food allergy. (22090174)
2012
13
Transient erythematous rash on the cheek mimicking food allergy. (22182440)
2012
14
Therapeutics in food allergy: the current state of the art. (22101989)
2012
15
Food allergy after cord blood stem cell transplantation with tacrolimus therapy in two patients who developed veno-occlusive disease. (22722810)
2012
16
Development and validation of educational materials for food allergy. (22082955)
2012
17
The role of genetics and environment in the rise of childhood food allergy. (21771119)
2012
18
Role of selenium and zinc in the pathogenesis of food allergy in infants and young children. (23319985)
2012
19
Sublingual vs oral immunotherapy for food allergy: identifying the right approach. (23009174)
2012
20
Children in the inner city of New York have high rates of food allergy and IgE sensitization to common foods. (21555148)
2011
21
The relationship of rhinitis and asthma, sinusitis, food allergy, and eczema. (21737039)
2011
22
Office-based oral immunotherapy for food allergy is safe and effective. (21040956)
2011
23
Predictors of childhood food allergy: significance and implications. (22299310)
2011
24
Phenotypes of IgE-mediated food allergy in Turkish children. (22221430)
2011
25
Primary care management of food allergy and food intolerance. (22095272)
2011
26
Outcomes of office-based, open food challenges in the management of food allergy. (21835446)
2011
27
Sensitization profiles of a case of pollen-food allergy syndrome. (21252619)
2011
28
Oral tolerance induction does not resolve gastrointestinal inflammation in a mouse model of food allergy. (21714123)
2011
29
Parent-reported food allergy requiring an avoidance diet in children starting elementary school. (21592224)
2011
30
Avoidance or exposure to foods in prevention and treatment of food allergy? (20431373)
2010
31
Defining the role of food allergy in a population of adult patients with eosinophilic esophagitis. (20887270)
2010
32
Nitration of the egg-allergen ovalbumin enhances protein allergenicity but reduces the risk for oral sensitization in a murine model of food allergy. (21151984)
2010
33
Montelukast treatment (cysteinyl leukotriene receptor antagonist) in a model of food allergy: modifications in lymphatic cell population from rectal mucosa. (20617862)
2010
34
Oral Bifidobacterium modulates intestinal immune inflammation in mice with food allergy. (20546446)
2010
35
Food allergy and eosinophilic esophagitis: learning what to avoid. (20048030)
2010
36
Researchers look to genetic analyses for new options in treating food allergy. (21063005)
2010
37
Food allergy Children. An update on diagnosis and treatment. (21299146)
2010
38
Food allergy after liver transplantation in children: a prospective study. (19239659)
2009
39
The role of protein digestibility and antacids on food allergy outcomes. (18539189)
2008
40
Food allergy to proteins. (17245088)
2007
41
Influence of SNPs in cytokine-related genes on the severity of food allergy and atopic eczema in children. (17121586)
2006
42
Rhinosinusitis derived Staphylococcal enterotoxin B plays a possible role in pathogenesis of food allergy. (16919166)
2006
43
Eosinophil cationic protein in serum of children with food allergy]. (12712820)
2003
44
Food allergy to wheat: identification of immunogloglin E and immunoglobulin G-binding proteins with sequential extracts and purified proteins from wheat flour. (12859454)
2003
45
Oral disodium cromoglycate and ketotifen for a patient with eosinophilic gastroenteritis, food allergy and protein-losing enteropathy. (15032404)
2003
46
Airway neutrophil inflammation in nonasthmatic patients with food allergy. (11972479)
2002
47
Microscopic and collagenous colitis in treated celiac disease due to food allergy? (10029639)
1999
48
Specific IgE against inhaled allergens in dystreptic children with food allergy]. (9156886)
1996
49
Immunologic reactivity in patients with food allergy]. (1774922)
1991
50
Food allergy in steroid-resistant nephrotic syndrome. (2884433)
1987

Genetic Variations for Food Allergy

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Expression for genes affiliated with Food Allergy

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Food Allergy

Search GEO for disease gene expression data for Food Allergy.

Pathways for genes affiliated with Food Allergy

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Sources:
37NCBI BioSystems Database, 29KEGG, 12EMD Millipore
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Compounds for genes affiliated with Food Allergy

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Sources:
44Novoseek, 11DrugBank, 28IUPHAR, 24HMDB, 49PharmGKB, 59Tocris Bioscience
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Compounds related to Food Allergy according to GeneCards/GeneDecks:

(show top 50)    (show all 83)
idCompoundScoreTop Affiliating Genes
1pge24410.8EPX
2omalizumab44 1111.7IGHE, IL5, MS4A2
3tele-methylhistamine4410.7IGHE, EPX, RNASE3
4lte44410.7EPX, RNASE3, IL5
5beclomethasone dipropionate4410.7IL5, RNASE3, IGHE
6toluene diisocyanate4410.7RNASE3, IL5, IGHE
7nedocromil sodium4410.6IGHE, IL5, RNASE3
8unicap4410.6RNASE3, CD14, IGHE, IL5
9sodium cromoglycate4410.6IGHE, EPX, RNASE3, IL5
10cetirizine44 28 11 2413.6IGHE, IL5, RNASE3, EPX
11ketotifen44 1111.6RNASE3, EPX, IGHE, IL5
12budesonide44 49 1112.6IL5, RNASE3, EPX, IGHE
13ovomucoid4410.6IGHE, CSN1S1, IL5
14salbutamol44 49 28 11 2414.6IGHE, EPX, IL5, RNASE3
15salmeterol44 49 28 1113.6IL5, EPX, RNASE3
16pgd24410.6IGHE, IL5, EPX, RNASE3
17praziquantel44 1111.6IGHE, RNASE3, IL5
18fluticasone propionate44 49 59 1113.6STAT6, IGHE, RNASE3, IL5
19azelastine44 1111.6IL5, RNASE3, IGHE
20methacholine44 1111.6RNASE3, IL5, IGHE, CD14
21glucono-delta-lactone4410.6CSN3, CSN1S1
22gliadin4410.6CSN1S1, IGHE, RNASE3
23montelukast44 49 28 1113.6IL5, RNASE3, IGHE
24percoll4410.6IL5, CD14, RNASE3
25heparin44 28 11 2413.6CETP, CD14, CSN1S1, EPX, RNASE3
26ltc44410.6RNASE3, IL5, EPX
27itraconazole44 1111.5CSN1S1, IGHE, IL5
28sodium caseinate4410.5CSN1S1, CSN3
29carbohydrates4410.5IGHE, CSN1S1, CETP, RNASE3, CD14
30lactose44 1111.5IL5, LGALS9, CSN1S1, CSN3
31rennet4410.5CSN1S1, CSN3
32prednisolone44 28 1112.5CD14, EPX, RNASE3, IL5, IGHE, CSN1S1
33cyclosporin a44 28 5912.4RNASE3, FOXP3, CD14, CETP, IL5, IGHE
34p0054410.4EPX, S100A8, RNASE3
35aluminium hydroxide4410.4CSN1S1, IGHE
36polyacrylamide4410.4CSN3, S100A8, CSN1S1, CD14, CETP
37thyroxine44 2411.4CSN1S1, CETP, IL5, IGHE
38urea44 11 2412.4RNASE3, CSN3, CSN1S1, S100A8
39allergens4410.4STAT6, CSN3, IGHE, EPX, RNASE3, IL5
40fmlp4410.4IL5, RNASE3, EPX, CD14
41dexamethasone44 49 28 1113.3RNASE3, EPX, IGHE, STAT6, S100A8, IL5
42creatinine4410.3CSN1S1, RNASE3, EPX, CD14, S100A8, IGHE
43histamine44 28 2412.3IL5, S100A8, CSN1S1, STAT6, IGHE, CD14
44retinoic acid44 2411.2CETP, IL5, RNASE3, CD14, IGHE, S100A8
45anti-fungal4410.2RNASE3, IL5, CETP
46glutamine4410.2CETP, IL5, CD14, CSN1S1, IGHE
47lactate4410.1RNASE3, CD14, CSN1S1, IGHE, EPX
48mometasone furoate44 5911.0RNASE3, IL5
49arginine4410.0CETP, CD14, CSN1S1, IGHE, RNASE3, IL5
50calcium44 49 11 2413.0TMEM37, EPX, RNASE3, LGALS9, CD14, S1PR1

GO Terms for genes affiliated with Food Allergy

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16Gene Ontology
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Cellular components related to Food Allergy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055769.8CETP, LGALS9, IL5, RNASE3, CD14, IGHE

Biological processes related to Food Allergy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of interleukin-5 productionGO:03271410.4EPX, FOXP3
2negative regulation of interleukin-10 productionGO:03269310.3EPX, FOXP3
3positive regulation of interleukin-4 productionGO:03275310.2EPX, FOXP3
4innate immune responseGO:04508710.1MS4A2, CD14, IGHE, STAT6, S100A8
5inflammatory responseGO:0069549.9S100A8, CD14, IL5, MS4A2

Products for genes affiliated with Food Allergy

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Food Allergy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet