MCID: FDL002
MIFTS: 60

Food Allergy malady

Immune diseases category

Summaries for Food Allergy

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8Disease Ontology, 33MedlinePlus, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Food allergy is an abnormal response to a food triggered by your body's immune system. in adults, the foods that most often trigger allergic reactions include fish, shellfish, peanuts, and tree nuts, such as walnuts. problem foods for children can include eggs, milk, peanuts, tree nuts, soy, and wheat. symptoms of food allergy include itching or swelling in your mouth vomiting, diarrhea, or abdominal cramps and pain hives or eczema tightening of the throat and trouble breathing drop in blood pressure your health care provider may use a detailed history, elimination diet, and skin and blood tests to diagnose a food allergy. when you have food allergies, you must be prepared to treat an accidental exposure. wear a medical alert bracelet or necklace, and carry an auto-injector device containing epinephrine (adrenaline). you can only prevent the symptoms of food allergy by avoiding the food. after you and your health care provider have identified the foods to which you are sensitive, you must remove them from your diet. nih: national institute of allergy and infectious diseases

MalaCards: Food Allergy, also known as food hypersensitivity, is related to dermatitis and atopic dermatitis. An important gene associated with Food Allergy is RNASE3 (ribonuclease, RNase A family, 3), and among its related pathways are IL4-mediated signaling events and Allograft rejection. The drugs prednisolone and prednisone and the compounds pge2 and omalizumab have been mentioned in the context of this disorder. Affiliated tissues include testes, skin and t cells, and related mouse phenotypes are hematopoietic system and immune system.

Disease Ontology:8 An allergy that is an abnormal response to a food, triggered by the body's immune system.

Wikipedia:63 A food allergy is an adverse immune response to a food protein. They are distinct from other adverse... more...

Aliases & Classifications for Food Allergy

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Sources:
8Disease Ontology, 10DISEASES, 33MedlinePlus, 60UMLS, 44Novoseek, 56SNOMED-CT, 34MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Immune diseases


Aliases & Descriptions:

food allergy 8 10 33 60
food hypersensitivity 8
hypersensitivity 60
allergy food 44


External Ids:

Disease Ontology8 DOID:3044
MeSH34 D005512

Related Diseases for Food Allergy

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Food Allergy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 481)
idRelated DiseaseScoreTop Affiliating Genes
1dermatitis31.0FOXP3, IGHE, IL5, MS4A2
2atopic dermatitis31.0CSN1S1, STAT6, RNASE3
3vasculitis31.0CD14
4asthma30.9IL5, RNASE3, EPX, IGHE
5egg allergy30.9IGHE, IL5
6eosinophilic esophagitis30.7IL5
7esophagitis30.7IL5, S100A8
8extrinsic allergic alveolitis30.7IGHE, CD14
9eosinophilic gastroenteritis30.5CSN1S1, IGHE, IL5
10pneumonia30.5S100A8, EPX, IL5
11skin disease30.4S100A8, STAT6, IGHE, RNASE3, IL5
12arthritis30.4S100A8, CSN1S1, FOXP3, STAT6
13peanut allergic reaction30.4IGHE, CSN1S1
14allergic asthma30.4STAT6, IGHE, CD14, EPX, RNASE3, IL5
15leukemia30.4S100A8, FOXP3, CD14, EPX, RNASE3
16celiac disease30.3CSN1S1, CCR9
17angioedema30.3IGHE, RNASE3, IL5
18gastritis30.3S100A8
19rhinitis30.3IGHE, EPX, RNASE3, IL5, MS4A2
20eosinophilia30.2FOXP3, STAT6, IGHE, CD14, EPX, RNASE3
21rheumatoid arthritis30.2CCR9, S100A8, CSN1S1, FOXP3, STAT6, CD14
22sarcoidosis30.2CD14
23ischemia30.1EPX, CD14
24eosinophilic pneumonia30.1IGHE, RNASE3, IL5
25allergic bronchopulmonary aspergillosis30.1IGHE, IL5
26conjunctivitis30.1MS4A2, RNASE3, IGHE
27diarrhea30.0CSN1S1
28nephrotic syndrome30.0CETP, CD14
29anisakiasis30.0RNASE3, IGHE
30gastroesophageal reflux disease30.0S100A8, CSN1S1
31allergic rhinitis30.0IL5, RNASE3, EPX, IGHE
32urticaria30.0RNASE3, IGHE, CSN1S1
33contact dermatitis30.0IL5, IGHE
34uveitis30.0CD14
35duodenitis30.0S100A8
36allergic conjunctivitis30.0IL5, RNASE3, IGHE
37hypersensitivity reaction type ii disease30.0S100A8, CSN3, CSN1S1, FOXP3, STAT6, IL5
38churg-strauss syndrome29.9IL5, RNASE3
39bullous pemphigoid29.9IGHE, RNASE3, IL5
40diabetes mellitus29.9CSN1S1, FOXP3, CD14, CETP
41tuberculosis29.9EPX
42peritonitis29.8CD14
43cystic fibrosis29.8S100A8, RNASE3
44bronchiolitis29.8IL5, RNASE3, IGHE
45ulcerative colitis29.8CSN1S1, STAT6, CD14, EPX, RNASE3
46atopy29.8CSN1S1, STAT6, IGHE, CD14, EPX, RNASE3
47wegener's granulomatosis29.8CD14
48multiple sclerosis29.8IL5, FOXP3, S100A8, S1PR1
49hepatitis b29.5CSN1S1
50otitis media29.5IGHE, CD14, RNASE3

Graphical network of the top 20 diseases related to Food Allergy:



Diseases related to food allergy

Clinical Features for Food Allergy

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Drugs & Therapeutics for Food Allergy

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Genetic Tests for Food Allergy

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Anatomical Context for Food Allergy

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32MalaCards
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MalaCards organs/tissues related to Food Allergy:

32
Testes, Skin, T cells, Liver, B cells, Small intestine, Breast, Endothelial, Colon

Animal Models for Food Allergy or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Food Allergy:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053979.8S1PR1, FOXP3, FAIM, STAT6, IGHE, EPX
2MP:00053879.3LGALS9, CCR9, S1PR1, FOXP3, FAIM, STAT6

Publications for Food Allergy

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Sources:
50PubMed
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Articles related to Food Allergy:

(show top 50)    (show all 641)
idTitleAuthorsYear
1
Primary prevention of food allergy in children and adults: systematic review. (24433563)
2014
2
Food Allergy and Anaphylaxis Meeting (FAAM 2013) Nice, France. 7-9 February 2013. Abstracts. (23902650)
2013
3
Introducing solid food: age of introduction and its effect on risk of food allergy and other atopic diseases. (23851527)
2013
4
Parsing the peanut panic: the social life of a contested food allergy epidemic. (23746608)
2013
5
Validation of the Paediatric Food Allergy Quality of Life Questionnaire (PFA-QL). (23590419)
2013
6
Impact of dietary factors and food processing on food allergy. (23148040)
2013
7
What's new in the diagnosis and management of food allergy in children? (23667831)
2013
8
Overview of evidence in prevention and aetiology of food allergy: a review of systematic reviews. (24192789)
2013
9
Heat treatment of egg white controls allergic symptoms and induces oral tolerance to ovalbumin in a murine model of food allergy. (23983060)
2013
10
Identification of an abundant 56 kDa protein implicated in food allergy as granule-bound starch synthase. (23675783)
2013
11
Tolerogenic CX3CR1+ B cells suppress food allergy-induced intestinal inflammation in mice. (24033604)
2013
12
Vitamin D insufficiency is associated with challenge-proven food allergy in infants. (23453797)
2013
13
Characterization of plasma cytokines in an infant population cohort of challenge-proven food allergy. (24033562)
2013
14
Misdiagnosed food allergy resulting in severe malnutrition in an infant. (23733797)
2013
15
Association between loss-of-function mutations in the filaggrin gene and self-reported food allergy and alcohol sensitivity. (23548340)
2013
16
Food Allergy and Quality of Life: What Have We Learned? (24122150)
2013
17
Maternal and newborn vitamin D status and its impact on food allergy development in the German LINA cohort study. (23253182)
2013
18
Incidence of fatal food anaphylaxis in people with food allergy: a systematic review and meta-analysis. (24118190)
2013
19
Allergic reactions to foods in preschool-aged children in a prospective observational food allergy study. (22732173)
2012
20
No filaggrin gene mutation in a patient with a combination of atopic dermatitis, alopecia areata and food allergy. (23174665)
2012
21
Treatments for food allergy: how close are we? (22434517)
2012
22
Overcoming food allergy through acquired tolerance conferred by transfer of Tregs in a murine model. (22050332)
2012
23
Quality of life measures for food allergy. (22239653)
2012
24
Cow's milk anaphylaxis in children first report of Iranian Food Allergy Registry. (22427474)
2012
25
Small-bowel capsule endoscopy in patients with gastrointestinal food allergy. (22035500)
2012
26
Geographic variability of childhood food allergy in the United States. (22605786)
2012
27
Fish and shellfish allergy in children: review of a persistent food allergy. (22554093)
2012
28
Food allergy and the development of asthma symptoms. (23058023)
2012
29
Common Methodologies in the Evaluation of Food Allergy: Pitfalls and Prospects of Food Allergy Prevalence Studies. (23179516)
2012
30
Heat-induced structural changes affect OVA-antigen processing and reduce allergic response in mouse model of food allergy. (22629361)
2012
31
A shorter and more specific oral sensitization-based experimental model of food allergy in mice. (22542400)
2012
32
Neural and behavioral correlates of food allergy. (22767066)
2012
33
Overall prevalence of self-reported food allergy in Canada. (22867693)
2012
34
Food allergy in patients with eczema: immediate symptoms are usual, with nuts and tomatoes the major allergens. (21668512)
2011
35
Increased serum YKL-40: a new potential marker for airway allergic responses in adult patients with food allergy. (21496058)
2011
36
Food allergy: practical considerations for primary care. (22073492)
2011
37
Food allergy. (21364287)
2011
38
Diagnosis and assessment of food allergy in children and young people in primary care and community settings: NICE clinical guideline. (21722479)
2011
39
Atopy patch test in the diagnosis of food allergy in children with gastrointestinal symptoms. (21084256)
2010
40
Protein-energy malnutrition and feeding refusal secondary to food allergies. (18509149)
2008
41
Reduced allergy rates in atopic eczema to contact allergens used in both skin products and foods: atopy and the 'hapten-atopy hypothesis'. (18279153)
2008
42
Egg allergy: are all childhood food allergies the same? (17444821)
2007
43
Sphingosine 1-phosphate-mediated trafficking of pathogenic Th2 and mast cells for the control of food allergy. (17641024)
2007
44
Allergies associated with both food and pollen]. (14626714)
2003
45
Challenge testes for diagnosis and follow-up of children with food allergy]. (12790076)
2003
46
Nonmurine animal models of food allergy. (12573913)
2003
47
Antacid medication inhibits digestion of dietary proteins and causes food allergy: a fish allergy model in BALB/c mice. (13679824)
2003
48
Increased expression of intercellular adhesion molecule-1 and mucosal adhesion molecule alpha4beta7 integrin in small intestinal mucosa of adult patients with food allergy. (11358431)
2001
49
Immunoglobulin E and eosinophilic cationic protein in segmental lavage fluid of the small and large bowel identify patients with food allergy. (11232698)
2001
50
CagA-positive Helicobacter pylori infection may increase the risk of food allergy development. (10695562)
1999

Genetic Variations for Food Allergy

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Expression for genes affiliated with Food Allergy

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Food Allergy

Search GEO for disease gene expression data for Food Allergy.

Pathways for genes affiliated with Food Allergy

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Sources:
37NCBI BioSystems Database, 29KEGG, 12EMD Millipore
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Compounds for genes affiliated with Food Allergy

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Sources:
44Novoseek, 11DrugBank, 28IUPHAR, 24HMDB, 49PharmGKB, 59Tocris Bioscience
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Compounds related to Food Allergy according to GeneCards/GeneDecks:

(show top 50)    (show all 83)
idCompoundScoreTop Affiliating Genes
1pge24410.8EPX
2omalizumab44 1111.7IGHE, IL5, MS4A2
3tele-methylhistamine4410.7IGHE, EPX, RNASE3
4beclomethasone dipropionate4410.7IGHE, RNASE3, IL5
5lte44410.7EPX, RNASE3, IL5
6toluene diisocyanate4410.7IGHE, RNASE3, IL5
7nedocromil sodium4410.6IGHE, RNASE3, IL5
8unicap4410.6IGHE, CD14, RNASE3, IL5
9sodium cromoglycate4410.6IGHE, EPX, RNASE3, IL5
10cetirizine44 28 11 2413.6IGHE, EPX, RNASE3, IL5
11ketotifen44 1111.6IL5, RNASE3, EPX, IGHE
12budesonide44 49 1112.6IL5, RNASE3, EPX, IGHE
13ovomucoid4410.6CSN1S1, IGHE, IL5
14salbutamol44 49 28 11 2414.6IGHE, EPX, RNASE3, IL5
15salmeterol44 49 28 1113.6EPX, RNASE3, IL5
16pgd24410.6IGHE, EPX, RNASE3, IL5
17praziquantel44 1111.6IGHE, RNASE3, IL5
18fluticasone propionate44 49 59 1113.6STAT6, IGHE, RNASE3, IL5
19azelastine44 1111.6IGHE, RNASE3, IL5
20methacholine44 1111.6IGHE, CD14, RNASE3, IL5
21glucono-delta-lactone4410.6CSN1S1, CSN3
22montelukast44 49 28 1113.6IGHE, RNASE3, IL5
23gliadin4410.6CSN1S1, IGHE, RNASE3
24itraconazole44 1111.6CSN1S1, IGHE, IL5
25percoll4410.6IL5, RNASE3, CD14
26heparin44 28 11 2413.6CETP, RNASE3, EPX, CD14, CSN1S1
27ltc44410.6EPX, RNASE3, IL5
28sodium caseinate4410.5CSN3, CSN1S1
29carbohydrates4410.5CETP, RNASE3, CD14, IGHE, CSN1S1
30lactose44 1111.5LGALS9, IL5, CSN1S1, CSN3
31rennet4410.5CSN3, CSN1S1
32prednisolone44 28 1112.5CSN1S1, IGHE, CD14, EPX, RNASE3, IL5
33cyclosporin a44 28 5912.4FOXP3, IGHE, CD14, RNASE3, IL5, CETP
34p0054410.4RNASE3, EPX, S100A8
35aluminium hydroxide4410.4IGHE, CSN1S1
36polyacrylamide4410.4S100A8, CSN3, CSN1S1, CD14, CETP
37thyroxine44 2411.4CETP, IL5, IGHE, CSN1S1
38urea44 11 2412.4RNASE3, CSN1S1, CSN3, S100A8
39allergens4410.4CETP, CSN3, STAT6, IGHE, EPX, RNASE3
40fmlp4410.4CD14, EPX, RNASE3, IL5
41dexamethasone44 49 28 1113.3S100A8, STAT6, IGHE, CD14, EPX, RNASE3
42creatinine4410.3S100A8, CSN1S1, IGHE, CD14, EPX, RNASE3
43histamine44 28 2412.3S100A8, CSN1S1, STAT6, IGHE, CD14, EPX
44retinoic acid44 2411.2S100A8, CSN1S1, STAT6, IGHE, CD14, RNASE3
45anti-fungal4410.2CETP, IL5, RNASE3
46glutamine4410.2CSN1S1, IGHE, CD14, IL5, CETP
47lactate4410.1RNASE3, EPX, CD14, IGHE, CSN1S1
48mometasone furoate44 5911.0RNASE3, IL5
49arginine4410.0CSN1S1, IGHE, CD14, RNASE3, IL5, CETP
50calcium44 49 11 2413.0CCR9, S1PR1, S100A8, CSN3, CSN1S1, STAT6

GO Terms for genes affiliated with Food Allergy

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16Gene Ontology
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Cellular components related to Food Allergy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055769.8CETP, LGALS9, IL5, RNASE3, CD14, IGHE

Biological processes related to Food Allergy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of interleukin-5 productionGO:03271410.4EPX, FOXP3
2negative regulation of interleukin-10 productionGO:03269310.3EPX, FOXP3
3positive regulation of interleukin-4 productionGO:03275310.2EPX, FOXP3
4innate immune responseGO:04508710.1MS4A2, CD14, IGHE, STAT6, S100A8
5inflammatory responseGO:0069549.9S100A8, CD14, IL5, MS4A2

Products for genes affiliated with Food Allergy

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Food Allergy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet