MCID: FDB001
MIFTS: 46

Foodborne Botulism

Categories: Rare diseases, Infectious diseases, Neuronal diseases

Aliases & Classifications for Foodborne Botulism

MalaCards integrated aliases for Foodborne Botulism:

Name: Foodborne Botulism 12 12 49 55 14
Botulism 12 72 49 55 51 40 3 41 14
Wound Botulism 49 69
Intoxication with Clostridium Botulinum Toxin 12
Food Poisoning Due to Clostridium Botulinum 12
Infection Due to Clostridium Botulinum 12
Intoxication Botulism 55
Botulism, Infantile 69
Botulism Poisoning 12
Infant Botulism 49

Characteristics:

Orphanet epidemiological data:

55
foodborne botulism
Prevalence: 1-9/1000000 (Europe),1-9/1000000 (Romania); Age of onset: All ages; Age of death: any age;
botulism
Prevalence: <1/1000000 (Europe),<1/1000000 (Worldwide),1-9/1000000 (France),1-9/1000000 (United States); Age of onset: All ages; Age of death: any age;

Classifications:



Summaries for Foodborne Botulism

MedlinePlus : 40 Botulism is a rare but serious illness. The cause is a toxin (poison) made by a bacterium called Clostridium botulinum. It occurs naturally in soil. There are several kinds of botulism. Foodborne botulism comes from eating foods contaminated with the toxin. Wound botulism happens when a wound infected with the bacteria makes the toxin. It is more common in heroin users. Infant botulism happens when a baby consumes the spores of the bacteria from soil or honey. All forms can be deadly and are medical emergencies. Symptoms include double or blurred vision, drooping eyelids, slurred speech, difficulty swallowing, dry mouth, and muscle weakness. Treatment may include antitoxins, intensive medical care, or surgery of infected wounds. To prevent botulism: Be very careful when canning foods at home Do not let babies eat honey Get prompt medical care for infected wounds Centers for Disease Control and Prevention

MalaCards based summary : Foodborne Botulism, also known as botulism, is related to wound botulism and infant botulism, and has symptoms including urinary retention, xerostomia and diplopia. An important gene associated with Foodborne Botulism is SNAP25 (Synaptosome Associated Protein 25), and among its related pathways/superpathways are Uptake and actions of bacterial toxins and Delta508-CFTR traffic / Sorting endosome formation in CF. The drugs Botulinum Antitoxin and Antitoxins have been mentioned in the context of this disorder. Affiliated tissues include neuromuscular junction, and related phenotype is normal.

Disease Ontology : 12 A primary bacterial infectious disease that involves intoxication caused by botulinum neurotoxins (BoNTA, B, E and F) located in neuromuscular junction resulting in descending muscle paralysis, has material basis in Clostridium botulinum A, has material basis in Clostridium botulinum B, has material basis in Clostridium botulinum E and has material basis in Clostridium botulinum F.

CDC : 3 Botulism is a rare but serious illness caused by a toxin that attacks the body’s nerves.

Wikipedia : 72 Botulism is a rare and potentially fatal illness caused by a toxin produced by the bacterium Clostridium... more...

Related Diseases for Foodborne Botulism

Diseases related to Foodborne Botulism via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 11)
# Related Disease Score Top Affiliating Genes
1 wound botulism 33.3 LY96 PAX3
2 infant botulism 31.6 BRD3 EEA1 LY96 SNAP25 SYT1 SYT2
3 intestinal botulism 12.4
4 inhalational botulism 12.2
5 iatrogenic botulism 12.1
6 adult intestinal botulism 12.1
7 toxin-mediated infectious botulism 12.0
8 presynaptic congenital myasthenic syndromes 10.0 SNAP25 SYT2
9 respiratory failure 10.0
10 alcohol-related birth defect 9.8 GP2 SNAP25 SV2C
11 swine influenza 9.6 GP2 HAS1

Graphical network of the top 20 diseases related to Foodborne Botulism:



Diseases related to Foodborne Botulism

Symptoms & Phenotypes for Foodborne Botulism

Human phenotypes related to Foodborne Botulism:

55 31 (show all 23)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 urinary retention 55 31 frequent (33%) Frequent (79-30%),Frequent (79-30%) HP:0000016
2 xerostomia 55 31 hallmark (90%) Very frequent (99-80%),Very frequent (99-80%) HP:0000217
3 diplopia 55 31 hallmark (90%) Very frequent (99-80%),Very frequent (99-80%) HP:0000651
4 dysarthria 55 31 hallmark (90%) Very frequent (99-80%),Very frequent (99-80%) HP:0001260
5 diarrhea 55 31 occasional (7.5%) Occasional (29-5%),Very frequent (99-80%) HP:0002014
6 dysphagia 55 31 hallmark (90%) Very frequent (99-80%),Very frequent (99-80%) HP:0002015
7 nausea and vomiting 55 31 frequent (33%) Frequent (79-30%),Frequent (79-30%) HP:0002017
8 constipation 55 31 frequent (33%) Frequent (79-30%),Very frequent (99-80%) HP:0002019
9 abdominal pain 55 31 hallmark (90%) Very frequent (99-80%),Very frequent (99-80%) HP:0002027
10 respiratory insufficiency 55 31 frequent (33%) Frequent (79-30%) HP:0002093
11 diaphragmatic paralysis 55 31 hallmark (90%) Very frequent (99-80%),Very frequent (99-80%) HP:0006597
12 cranial nerve paralysis 55 31 hallmark (90%) Very frequent (99-80%),Very frequent (99-80%) HP:0006824
13 muscle flaccidity 55 31 hallmark (90%) Very frequent (99-80%) HP:0010547
14 mydriasis 55 31 hallmark (90%) Very frequent (99-80%),Very frequent (99-80%) HP:0011499
15 arrhythmia 55 31 frequent (33%) Frequent (79-30%),Frequent (79-30%) HP:0011675
16 cerebral palsy 55 31 hallmark (90%) Very frequent (99-80%),Very frequent (99-80%) HP:0100021
17 fatigue 55 31 hallmark (90%) Very frequent (99-80%) HP:0012378
18 ptosis 55 31 hallmark (90%) Very frequent (99-80%) HP:0000508
19 respiratory insufficiency due to muscle weakness 55 31 frequent (33%) Frequent (79-30%) HP:0002747
20 cardiorespiratory arrest 55 31 occasional (7.5%) Occasional (29-5%) HP:0006543
21 diaphragmatic weakness 55 Occasional (29-5%)
22 muscle weakness 55 Very frequent (99-80%)
23 paralysis 55 Very frequent (99-80%)

MGI Mouse Phenotypes related to Foodborne Botulism:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 normal MP:0002873 9.1 GP2 HAS1 PAX3 SNAP25 SYT1 SYT2

Drugs & Therapeutics for Foodborne Botulism

Drugs for Foodborne Botulism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Botulinum Antitoxin Phase 4
2 Antitoxins Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Botulism Outbreak in Thailand (Episode II) Completed NCT00348426 Phase 4 Botulinum AntiToxin

Search NIH Clinical Center for Foodborne Botulism

Cochrane evidence based reviews: botulism

Genetic Tests for Foodborne Botulism

Anatomical Context for Foodborne Botulism

The Foundational Model of Anatomy Ontology organs/tissues related to Foodborne Botulism:

18
Neuromuscular Junction

Publications for Foodborne Botulism

Articles related to Foodborne Botulism:

(show top 50) (show all 66)
# Title Authors Year
1
Foodborne botulism due to ingestion of home-canned green beans: two case reports. ( 29301587 )
2018
2
Foodborne botulism in the Faroe Islands in a two-decade period. ( 28597722 )
2017
3
Outbreak of Foodborne Botulism in an Immigrant Community: Overcoming Delayed Disease Recognition, Ambiguous Epidemiologic Links, and Cultural Barriers to Identify the Cause. ( 29293929 )
2017
4
Efficacy of Antitoxin Therapy in Treating Patients With Foodborne Botulism: A Systematic Review and Meta-analysis of Cases, 1923-2016. ( 29293927 )
2017
5
Foodborne Botulism, I Only Had Nacho Cheese: A Case Report. ( 29152423 )
2017
6
The Epidemiology of Foodborne Botulism Outbreaks: A Systematic Review. ( 29293934 )
2017
7
Foodborne botulism in Poland in 2015 ( 29182078 )
2017
8
Early diagnosis and treatment in a child with foodborne botulism. ( 26688278 )
2016
9
Foodborne botulism in Poland in 2014 ( 27779837 )
2016
10
Outbreak of Foodborne Botulism Associated with Improperly Jarred Pesto - Ohio and California, 2014. ( 26914208 )
2016
11
Foodborne botulism associated with home-preserved turnip tops in Italy. ( 25857385 )
2015
12
Regional variations in home canning practices and the risk of foodborne botulism in the republic of georgia, 2003. ( 25836400 )
2015
13
Foodborne botulism in Poland in 2013. ( 26233080 )
2015
14
Whole-Genome Sequence of Clostridium botulinum A2B3 87, a Highly Virulent Strain Involved in a Fatal Case of Foodborne Botulism in Italy. ( 25814616 )
2015
15
Foodborne botulism in Poland in 2012. ( 25135509 )
2014
16
Outbreak of type E foodborne botulism linked to traditionally prepared salted fish in Ontario, Canada. ( 25188279 )
2014
17
Outbreak of type A foodborne botulism at a boarding school, Uganda, 2008. ( 24576562 )
2014
18
Foodborne botulism treated with heptavalent botulism antitoxin. ( 23362041 )
2013
19
National outbreak of type a foodborne botulism associated with a widely distributed commercially canned hot dog chili sauce. ( 23097586 )
2013
20
An outbreak of foodborne botulism in Surat Thani Province, Thailand, 2012. ( 23883854 )
2013
21
Foodborne botulism in Poland in 2111. ( 24040723 )
2013
22
Foodborne botulism in Canada, 1985-2005. ( 23735780 )
2013
23
Diplopia as the primary presentation of foodborne botulism. ( 22993467 )
2012
24
Treatment of foodborne botulism in current clinical toxicology: authors' reply. ( 25396032 )
2012
25
Treatment of foodborne botulism in current clinical toxicology. ( 22803000 )
2012
26
Rapid detection of foodborne botulism outbreaks facilitated by epidemiological linking of cases: implications for food defense and public health response. ( 22315952 )
2012
27
Two unlinked cases of foodborne botulism in Italy at the beginning of 2010. ( 21811749 )
2011
28
Fatal course of foodborne botulism in an eight-month old infant. ( 22355516 )
2011
29
Endemic foodborne botulism among Alaska Native persons--Alaska, 1947-2007. ( 21292663 )
2011
30
One collective case of type A foodborne botulism in Corsica. ( 21970773 )
2011
31
Epidemiology of foodborne botulism in Romania 1980-2009. ( 21495856 )
2011
32
Three outbreaks of foodborne botulism caused by unsafe home canning of vegetables--Ohio and Washington, 2008 and 2009. ( 22186049 )
2011
33
Foodborne botulism in southwest Romania during the post-communism period 1990-2007. ( 19535277 )
2010
34
The role of a poison control center in identifying and limiting an outbreak of foodborne botulism. ( 20494246 )
2010
35
Multilocus outbreak of foodborne botulism linked to contaminated sausage in Hebei province, China. ( 20569065 )
2010
36
An outbreak of foodborne botulism in Taiwan. ( 18396100 )
2009
37
Signs and symptoms predictive of respiratory failure in patients with foodborne botulism in Thailand. ( 17690419 )
2007
38
Foodborne botulism from home-prepared fermented tofu--California, 2006. ( 17287713 )
2007
39
Outbreak of foodborne botulism linked to barbecue, Austria, 2006. ( 17213568 )
2006
40
Two cases of foodborne botulism with home-preserved asparagus. ( 16557441 )
2006
41
The safety of pasteurised in-pack chilled meat products with respect to the foodborne botulism hazard. ( 22063745 )
2005
42
Foodborne botulism in the Republic of Georgia: implications for preparedness planning. ( 15307003 )
2004
43
Foodborne botulism in the Republic of Georgia. ( 15498162 )
2004
44
Foodborne botulism in the United States, 1990-2000. ( 15498163 )
2004
45
Signs and symptoms predictive of death in patients with foodborne botulism--Republic of Georgia, 1980-2002. ( 15307002 )
2004
46
An outbreak of foodborne botulism associated with food sold at a salvage store in Texas. ( 14614672 )
2003
47
Nine cases of foodborne botulism type B in France and literature review. ( 14605938 )
2003
48
Foodborne botulism in a six-month-old infant caused by home-canned baby food. ( 12883510 )
2003
49
An outbreak of foodborne botulism in Ontario. ( 18159458 )
2003
50
Two cases of foodborne botulism type E and review of epidemiology in France. ( 11347670 )
2001

Variations for Foodborne Botulism

Expression for Foodborne Botulism

Search GEO for disease gene expression data for Foodborne Botulism.

Pathways for Foodborne Botulism

GO Terms for Foodborne Botulism

Cellular components related to Foodborne Botulism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell junction GO:0030054 9.71 SNAP25 SV2C SYT1 SYT2
2 cytoplasmic vesicle GO:0031410 9.62 EEA1 SV2C SYT1 SYT2
3 synapse GO:0045202 9.56 SNAP25 SV2C SYT1 SYT2
4 presynaptic membrane GO:0042734 9.46 SNAP25 SYT1
5 SNARE complex GO:0031201 9.43 SNAP25 SYT1
6 clathrin-coated vesicle membrane GO:0030665 9.37 SYT1 SYT2
7 synaptic vesicle membrane GO:0030672 9.33 SV2C SYT1 SYT2
8 chromaffin granule membrane GO:0042584 8.96 SYT1 SYT2
9 synaptic vesicle GO:0008021 8.92 SNAP25 SV2C SYT1 SYT2

Biological processes related to Foodborne Botulism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chemical synaptic transmission GO:0007268 9.63 SNAP25 SV2C SYT1
2 calcium ion-regulated exocytosis of neurotransmitter GO:0048791 9.43 SYT1 SYT2
3 regulation of calcium ion-dependent exocytosis GO:0017158 9.4 SYT1 SYT2
4 glutamate secretion GO:0014047 9.37 SNAP25 SYT1
5 synaptic vesicle exocytosis GO:0016079 9.32 SNAP25 SYT1
6 synaptic vesicle endocytosis GO:0048488 9.26 SYT1 SYT2
7 positive regulation of dendrite extension GO:1903861 9.16 SYT1 SYT2
8 vesicle fusion GO:0006906 9.13 EEA1 SYT1 SYT2
9 neurotransmitter secretion GO:0007269 8.8 SNAP25 SYT1 SYT2

Molecular functions related to Foodborne Botulism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 calcium-dependent protein binding GO:0048306 9.32 SNAP25 SYT1
2 calcium-dependent phospholipid binding GO:0005544 9.26 SYT1 SYT2
3 clathrin binding GO:0030276 9.16 SYT1 SYT2
4 syntaxin-1 binding GO:0017075 8.96 SNAP25 SYT1
5 1-phosphatidylinositol binding GO:0005545 8.62 EEA1 SYT1

Sources for Foodborne Botulism

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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