MCID: FDB001
MIFTS: 45

Foodborne Botulism

Categories: Rare diseases, Infectious diseases, Neuronal diseases

Aliases & Classifications for Foodborne Botulism

MalaCards integrated aliases for Foodborne Botulism:

Name: Foodborne Botulism 12 12 50 56 14
Botulism 12 50 56 52 41 3 42 14
Wound Botulism 50 69
Intoxication with Clostridium Botulinum Toxin 12
Food Poisoning Due to Clostridium Botulinum 12
Infection Due to Clostridium Botulinum 12
Intoxication Botulism 56
Botulism, Infantile 69
Botulism Poisoning 12
Infant Botulism 50

Characteristics:

Orphanet epidemiological data:

56
foodborne botulism
Prevalence: 1-9/1000000 (Europe),1-9/1000000 (Romania); Age of onset: All ages; Age of death: any age;
botulism
Prevalence: <1/1000000 (Europe),<1/1000000 (Worldwide),1-9/1000000 (France),1-9/1000000 (United States); Age of onset: All ages; Age of death: any age;

Classifications:



Summaries for Foodborne Botulism

MedlinePlus : 41 botulism is a rare but serious illness. the cause is a toxin (poison) made by a bacterium called clostridium botulinum. it occurs naturally in soil. there are several kinds of botulism. foodborne botulism comes from eating foods contaminated with the toxin. wound botulism happens when a wound infected with the bacteria makes the toxin. it is more common in heroin users. infant botulism happens when a baby consumes the spores of the bacteria from soil or honey. all forms can be deadly and are medical emergencies. symptoms include double or blurred vision, drooping eyelids, slurred speech, difficulty swallowing, dry mouth, and muscle weakness. treatment may include antitoxins, intensive medical care, or surgery of infected wounds. to prevent botulism: be very careful when canning foods at home do not let babies eat honey get prompt medical care for infected wounds centers for disease control and prevention

MalaCards based summary : Foodborne Botulism, also known as botulism, is related to infant botulism and wound botulism, and has symptoms including dysphagia, dysarthria and diarrhea. An important gene associated with Foodborne Botulism is SNAP25 (Synaptosome Associated Protein 25), and among its related pathways/superpathways are Uptake and actions of bacterial toxins and Delta508-CFTR traffic / Sorting endosome formation in CF. The drugs Antitoxins and Botulinum Antitoxin have been mentioned in the context of this disorder. Related phenotype is normal.

CDC : 3 Botulism is a rare but serious illness caused by a toxin that attacks the body’s nerves.

Disease Ontology : 12 A primary bacterial infectious disease that involves intoxication caused by botulinum neurotoxins (BoNTA, B, E and F) located in neuromuscular junction, resulting in descending muscle paralysis, has material basis in Clostridium botulinum A, has material basis in Clostridium botulinum B, has material basis in Clostridium botulinum E and has material basis in Clostridium botulinum F.

Wikipedia : 72 Botulism is a rare and potentially fatal illness caused by a toxin produced by the bacterium Clostridium... more...

Related Diseases for Foodborne Botulism

Diseases related to Foodborne Botulism via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 16)
id Related Disease Score Top Affiliating Genes
1 infant botulism 27.8 BRD3 EEA1 GP2 HAS1 LY96 PAX3
2 wound botulism 12.3
3 sudden infant death syndrome 9.9
4 colobomatous microphthalmia 9.9 SNAP25 SYT2
5 respiratory failure 9.9
6 polycystic echinococcosis 9.9 GP2 HAS1
7 clostridium difficile colitis 9.8
8 colitis 9.8
9 female breast cancer 9.8 GP2 SNAP25 SV2C
10 cholera 9.6
11 bronchiolitis 9.6
12 hypotonia 9.6
13 neuroblastoma 9.6
14 down syndrome 9.6
15 glandular tularemia 9.6 LY96 PAX3
16 typhoidal tularemia 8.1 BRD3 EEA1 LY96 SNAP25 SYT1 SYT2

Graphical network of the top 20 diseases related to Foodborne Botulism:



Diseases related to Foodborne Botulism

Symptoms & Phenotypes for Foodborne Botulism

Human phenotypes related to Foodborne Botulism:

56 32 (show all 23)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 dysphagia 56 32 hallmark (90%) Very frequent (99-80%),Very frequent (99-80%) HP:0002015
2 dysarthria 56 32 hallmark (90%) Very frequent (99-80%),Very frequent (99-80%) HP:0001260
3 diarrhea 56 32 occasional (7.5%) Occasional (29-5%),Very frequent (99-80%) HP:0002014
4 diplopia 56 32 hallmark (90%) Very frequent (99-80%),Very frequent (99-80%) HP:0000651
5 ptosis 56 32 hallmark (90%) Very frequent (99-80%) HP:0000508
6 fatigue 56 32 hallmark (90%) Very frequent (99-80%) HP:0012378
7 constipation 56 32 frequent (33%) Frequent (79-30%),Very frequent (99-80%) HP:0002019
8 arrhythmia 56 32 frequent (33%) Frequent (79-30%),Frequent (79-30%) HP:0011675
9 respiratory insufficiency due to muscle weakness 56 32 frequent (33%) Frequent (79-30%) HP:0002747
10 respiratory insufficiency 56 32 frequent (33%) Frequent (79-30%) HP:0002093
11 abdominal pain 56 32 hallmark (90%) Very frequent (99-80%),Very frequent (99-80%) HP:0002027
12 urinary retention 56 32 frequent (33%) Frequent (79-30%),Frequent (79-30%) HP:0000016
13 cerebral palsy 56 32 hallmark (90%) Very frequent (99-80%),Very frequent (99-80%) HP:0100021
14 xerostomia 56 32 hallmark (90%) Very frequent (99-80%),Very frequent (99-80%) HP:0000217
15 diaphragmatic paralysis 56 32 hallmark (90%) Very frequent (99-80%),Very frequent (99-80%) HP:0006597
16 cranial nerve paralysis 56 32 hallmark (90%) Very frequent (99-80%),Very frequent (99-80%) HP:0006824
17 nausea and vomiting 56 32 frequent (33%) Frequent (79-30%),Frequent (79-30%) HP:0002017
18 mydriasis 56 32 hallmark (90%) Very frequent (99-80%),Very frequent (99-80%) HP:0011499
19 muscle flaccidity 56 32 hallmark (90%) Very frequent (99-80%) HP:0010547
20 cardiorespiratory arrest 56 32 occasional (7.5%) Occasional (29-5%) HP:0006543
21 muscle weakness 56 Very frequent (99-80%)
22 diaphragmatic weakness 56 Occasional (29-5%)
23 paralysis 56 Very frequent (99-80%)

MGI Mouse Phenotypes related to Foodborne Botulism:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 normal MP:0002873 9.1 GP2 HAS1 PAX3 SNAP25 SYT1 SYT2

Drugs & Therapeutics for Foodborne Botulism

Drugs for Foodborne Botulism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 17)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1 Antitoxins Phase 4,Phase 1
2 Botulinum Antitoxin Phase 4,Phase 1
3 Botulinum Toxins Phase 4,Phase 1
4
4-Aminopyridine Approved Phase 2, Phase 3 504-24-5 1727
5 3,4-diaminopyridine Phase 2, Phase 3
6 Potassium Channel Blockers Phase 2, Phase 3
7
Aluminum hydroxide Approved Phase 2 21645-51-2
8 Vaccines Phase 2
9
Acetylcholine Approved Phase 1 51-84-3 187
10 Antibodies Phase 1
11 Immunoglobulins Phase 1
12 Cholinergic Agents Phase 1
13 Neurotransmitter Agents Phase 1
14 Antibodies, Monoclonal Phase 1
15 gamma-Globulins
16 Immunoglobulins, Intravenous
17 Rho(D) Immune Globulin

Interventional clinical trials:

(show all 11)

id Name Status NCT ID Phase Drugs
1 Botulism Outbreak in Thailand (Episode II) Completed NCT00348426 Phase 4 Botulinum AntiToxin
2 BT-011 Pharmacokinetics of Botulism Antitoxin Heptavalent in Pediatric Patients Enrolling by invitation NCT02051062 Phase 4
3 Pilot Study on the Usefulness of 3,4-diaminopyridine in the Treatment of Botulism Completed NCT01441557 Phase 2, Phase 3 3,4-diaminopyridine
4 Safety, Tolerability, and Immunogenicity Study of Investigational Recombinant Botulinum Vaccine A/B (rBV A/B) in Volunteers Previously Immunized With Investigational Pentavalent Botulinum Toxoid Completed NCT01701999 Phase 2
5 Botulism Antitoxin Effects on Paralysis Induced by Botulinum Neurotoxins in the EDB Muscle Completed NCT00636519 Phase 1
6 Phase 1 PK Study of XOMA 3AB Completed NCT01357213 Phase 1 XOMA 3AB
7 Evaluation of the Improvement of Quality of Life of Patients Suffering From Hailey Hailey or Darier Disease After Injections of Botulism Toxin Into Large Folds. Active, not recruiting NCT02782702 Phase 1 Botulism Toxin Treatment
8 Phase I, Dose Escalation Study to Evaluate the Safety and Pharmacokinetics of NTM-1632 Active, not recruiting NCT02779140 Phase 1
9 Study of Human Botulism Immunoglobulin in Infants With Botulism Completed NCT00004401 botulism immune globulin
10 Treatment of Survivors After Botulism Outbreak Completed NCT00314080 Botulinum AntiToxin
11 BT-010 Registry for the Evaluation of Safety and Clinical Outcomes in Patients Treated With Botulinum Antitoxin Enrolling by invitation NCT02055183 BAT

Search NIH Clinical Center for Foodborne Botulism

Cochrane evidence based reviews: botulism

Genetic Tests for Foodborne Botulism

Anatomical Context for Foodborne Botulism

Publications for Foodborne Botulism

Articles related to Foodborne Botulism:

(show top 50) (show all 60)
id Title Authors Year
1
Foodborne botulism in the Faroe Islands in a two-decade period. ( 28597722 )
2017
2
Outbreak of Foodborne Botulism Associated with Improperly Jarred Pesto - Ohio and California, 2014. ( 26914208 )
2016
3
Foodborne botulism in Poland in 2014 ( 27779837 )
2016
4
Early diagnosis and treatment in a child with foodborne botulism. ( 26688278 )
2016
5
Regional variations in home canning practices and the risk of foodborne botulism in the republic of georgia, 2003. ( 25836400 )
2015
6
Whole-Genome Sequence of Clostridium botulinum A2B3 87, a Highly Virulent Strain Involved in a Fatal Case of Foodborne Botulism in Italy. ( 25814616 )
2015
7
Foodborne botulism associated with home-preserved turnip tops in Italy. ( 25857385 )
2015
8
Foodborne botulism in Poland in 2013. ( 26233080 )
2015
9
Outbreak of type E foodborne botulism linked to traditionally prepared salted fish in Ontario, Canada. ( 25188279 )
2014
10
Outbreak of type A foodborne botulism at a boarding school, Uganda, 2008. ( 24576562 )
2014
11
Foodborne botulism in Poland in 2012. ( 25135509 )
2014
12
Foodborne botulism in Poland in 2111. ( 24040723 )
2013
13
National outbreak of type a foodborne botulism associated with a widely distributed commercially canned hot dog chili sauce. ( 23097586 )
2013
14
Foodborne botulism in Canada, 1985-2005. ( 23735780 )
2013
15
An outbreak of foodborne botulism in Surat Thani Province, Thailand, 2012. ( 23883854 )
2013
16
Foodborne botulism treated with heptavalent botulism antitoxin. ( 23362041 )
2013
17
Rapid detection of foodborne botulism outbreaks facilitated by epidemiological linking of cases: implications for food defense and public health response. ( 22315952 )
2012
18
Diplopia as the primary presentation of foodborne botulism. ( 22993467 )
2012
19
Treatment of foodborne botulism in current clinical toxicology: authors' reply. ( 25396032 )
2012
20
Treatment of foodborne botulism in current clinical toxicology. ( 22803000 )
2012
21
Three outbreaks of foodborne botulism caused by unsafe home canning of vegetables--Ohio and Washington, 2008 and 2009. ( 22186049 )
2011
22
Two unlinked cases of foodborne botulism in Italy at the beginning of 2010. ( 21811749 )
2011
23
Epidemiology of foodborne botulism in Romania 1980-2009. ( 21495856 )
2011
24
Endemic foodborne botulism among Alaska Native persons--Alaska, 1947-2007. ( 21292663 )
2011
25
Fatal course of foodborne botulism in an eight-month old infant. ( 22355516 )
2011
26
One collective case of type A foodborne botulism in Corsica. ( 21970773 )
2011
27
Foodborne botulism in southwest Romania during the post-communism period 1990-2007. ( 19535277 )
2010
28
The role of a poison control center in identifying and limiting an outbreak of foodborne botulism. ( 20494246 )
2010
29
Multilocus outbreak of foodborne botulism linked to contaminated sausage in Hebei province, China. ( 20569065 )
2010
30
An outbreak of foodborne botulism in Taiwan. ( 18396100 )
2009
31
Foodborne botulism from home-prepared fermented tofu--California, 2006. ( 17287713 )
2007
32
Signs and symptoms predictive of respiratory failure in patients with foodborne botulism in Thailand. ( 17690419 )
2007
33
Outbreak of foodborne botulism linked to barbecue, Austria, 2006. ( 17213568 )
2006
34
Two cases of foodborne botulism with home-preserved asparagus. ( 16557441 )
2006
35
The safety of pasteurised in-pack chilled meat products with respect to the foodborne botulism hazard. ( 22063745 )
2005
36
Foodborne botulism in the Republic of Georgia: implications for preparedness planning. ( 15307003 )
2004
37
Foodborne botulism in the United States, 1990-2000. ( 15498163 )
2004
38
Signs and symptoms predictive of death in patients with foodborne botulism--Republic of Georgia, 1980-2002. ( 15307002 )
2004
39
Foodborne botulism in the Republic of Georgia. ( 15498162 )
2004
40
Nine cases of foodborne botulism type B in France and literature review. ( 14605938 )
2003
41
Foodborne botulism in a six-month-old infant caused by home-canned baby food. ( 12883510 )
2003
42
An outbreak of foodborne botulism associated with food sold at a salvage store in Texas. ( 14614672 )
2003
43
An outbreak of foodborne botulism in Ontario. ( 18159458 )
2003
44
Two cases of foodborne botulism type E and review of epidemiology in France. ( 11347670 )
2001
45
From the Center for Disease Control and Prevention. Foodborne botulism from eating home-pickled eggs--Illinois, 1997. ( 11184244 )
2000
46
Foodborne botulism from eating home-pickled eggs--Illinois, 1997. ( 10987245 )
2000
47
Foodborne botulism outbreaks following consumption of home-canned bamboo shoots in Northern Thailand. ( 11075968 )
2000
48
Foodborne botulism associated with home-canned bamboo shoots--Thailand, 1998. ( 10372500 )
1999
49
Surveillance of foodborne botulism in Poland: 1960-1998. ( 12631899 )
1999
50
Foodborne botulism in Italy. ( 8950913 )
1996

Variations for Foodborne Botulism

Expression for Foodborne Botulism

Search GEO for disease gene expression data for Foodborne Botulism.

Pathways for Foodborne Botulism

GO Terms for Foodborne Botulism

Cellular components related to Foodborne Botulism according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cell junction GO:0030054 9.71 SNAP25 SV2C SYT1 SYT2
2 cytoplasmic vesicle GO:0031410 9.62 EEA1 SV2C SYT1 SYT2
3 synapse GO:0045202 9.56 SNAP25 SV2C SYT1 SYT2
4 presynaptic membrane GO:0042734 9.46 SNAP25 SYT1
5 SNARE complex GO:0031201 9.43 SNAP25 SYT1
6 clathrin-coated vesicle membrane GO:0030665 9.37 SYT1 SYT2
7 synaptic vesicle membrane GO:0030672 9.33 SV2C SYT1 SYT2
8 chromaffin granule membrane GO:0042584 8.96 SYT1 SYT2
9 synaptic vesicle GO:0008021 8.92 SNAP25 SV2C SYT1 SYT2

Biological processes related to Foodborne Botulism according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 calcium ion-regulated exocytosis of neurotransmitter GO:0048791 9.43 SYT1 SYT2
2 regulation of calcium ion-dependent exocytosis GO:0017158 9.4 SYT1 SYT2
3 glutamate secretion GO:0014047 9.37 SNAP25 SYT1
4 synaptic vesicle exocytosis GO:0016079 9.32 SNAP25 SYT1
5 synaptic vesicle endocytosis GO:0048488 9.26 SYT1 SYT2
6 positive regulation of dendrite extension GO:1903861 9.16 SYT1 SYT2
7 vesicle fusion GO:0006906 9.13 EEA1 SYT1 SYT2
8 neurotransmitter secretion GO:0007269 8.8 SNAP25 SYT1 SYT2

Molecular functions related to Foodborne Botulism according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 calcium-dependent protein binding GO:0048306 9.32 SNAP25 SYT1
2 calcium-dependent phospholipid binding GO:0005544 9.26 SYT1 SYT2
3 clathrin binding GO:0030276 9.16 SYT1 SYT2
4 syntaxin-1 binding GO:0017075 8.96 SNAP25 SYT1
5 1-phosphatidylinositol binding GO:0005545 8.62 EEA1 SYT1

Sources for Foodborne Botulism

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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