MCID: FTD001
MIFTS: 37

Foot Drop malady

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Summaries for Foot Drop

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NINDS:43 Foot drop describes the inability to raise the front part of the foot due to weakness or paralysis of the muscles that lift the foot. As a result, individuals with foot drop scuff their toes along the ground or bend their knees to lift their foot higher than usual to avoid the scuffing, which causes what is called a ?steppage? gait. Foot drop can be unilateral (affecting one foot) or bilateral (affecting both feet). Foot drop is a symptom of an underlying problem and is either temporary or permanent, depending on the cause. Causes include: neurodegenerative disorders of the brain that cause muscular problems, such as multiple sclerosis, stroke, and cerebral palsy; motor neuron disorders such as polio, some forms of spinal muscular atrophy and amyotrophic lateral sclerosis (commonly known as Lou Gehrig?s disease); injury to the nerve roots, such as in spinal stenosis; peripheral nerve disorders such as Charcot-Marie-Tooth disease or acquired peripheral neuropathy; local compression or damage to the peroneal nerve as it passes across the fibular bone below the knee; and muscle disorders, such as muscular dystrophy or myositis.

MalaCards based summary: Foot Drop, also known as foot-drop, is related to hereditary neuropathy with liability to pressure palsies and neuropathy. An important gene associated with Foot Drop is MPZ (myelin protein zero), and among its related pathways is Neural Crest Differentiation. The compounds curcumin and dihydroprogesterone have been mentioned in the context of this disorder. Affiliated tissues include brain, bone and spinal cord, and related mouse phenotypes are reproductive system and nervous system.

Wikipedia:65 Foot drop is a gait abnormality in which the dropping of the forefoot happens due to weakness,... more...

Aliases & Classifications for Foot Drop

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Foot Drop, Aliases & Descriptions:

Name: Foot Drop 43
 
Foot-Drop 62


Related Diseases for Foot Drop

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Graphical network of the top 20 diseases related to Foot Drop:



Diseases related to foot drop

Symptoms for Foot Drop

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Drugs & Therapeutics for Foot Drop

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Drug clinical trials:

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Genetic Tests for Foot Drop

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Anatomical Context for Foot Drop

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MalaCards organs/tissues related to Foot Drop:

32
Brain, Bone, Spinal cord, Prostate, Cortex, Skin, Testes, Myeloid, B cells

Animal Models for Foot Drop or affiliated genes

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MGI Mouse Phenotypes related to Foot Drop:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053898.5MPZ, TNF, PMP22
2MP:00036318.5MPZ, TNF, PMP22
3MP:00053868.4PMP22, TNF, MPZ
4MP:00053848.2PMP22, TNF, MPZ

Publications for Foot Drop

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Articles related to Foot Drop:

(show top 50)    (show all 260)
idTitleAuthorsYear
1
Differential diagnosis of foot drop: foot drop stroke syndrome. (25058947)
2014
2
Comparative analysis and quantitative evaluation of ankle-foot orthoses for foot drop in chronic hemiparetic patients. (25184801)
2014
3
Reply to Comments on 'Gait Disturbance due to Foot Drop Is Refractory to Treatment in Nonsystemic Vasculitic Neuropathy' (25401459)
2014
4
Experiences of functional electrical stimulation (FES) and ankle foot orthoses (AFOs) for foot-drop in people with multiple sclerosis. (24796365)
2014
5
Unilateral Foot Drop as an Initial Presentation of a Brain Tumor in a Child. (23456535)
2013
6
Kinetics and kinematics after the Bridle procedure for treatment of traumatic foot drop. (23684087)
2013
7
Spastic foot-drop as an isolated manifestation of neurocysticercosis. (23008377)
2012
8
Solitary lumbar osteochondroma presenting with foot-drop: a case report. (22665015)
2012
9
A clinical trial of a prototype of wireless surface fes rehabilitation system in foot drop correction. (22255573)
2011
10
Maternal sacral fracture during delivery causing foot drop. (21978815)
2011
11
Clinical features of central isolated unilateral foot drop: A case report and review of the literature. (21541007)
2011
12
Lumbar subdural hematoma from intracranial subarachnoid hemorrhage presenting with bilateral foot drop: case report. (21311278)
2011
13
A rare reason of foot drop caused by primary diffuse large b-cell lymphoma of the sciatic nerve: case report. (19415174)
2010
14
A bilateral foot drop due to neuroschistosomiasis. (20127348)
2010
15
A foot-drop case. (20440657)
2010
16
Foot drop--an unusual presentation of exertional compartment syndrome. (19423978)
2009
17
Interosseous nerve transfers for tibialis anterior muscle paralysis (foot drop): a human cadaver-based feasibility study. (19048462)
2009
18
Giant popliteal aneurysm with deep vein thrombosis, foot drop and arteriomegali. (21686392)
2009
19
Foot-drop: an unusual complaint in Henoch-SchAPnlein purpura. (18773224)
2009
20
Foot drop of sudden onset caused by acute hematoma in the lumbar ligamentum flavum: a case report and review of the literature. (18628701)
2008
21
Neuropathic pain and foot drop related to nerve injury after short duration surgery and caudal analgesia. (18716505)
2008
22
Delayed diagnosis of brain tumor in a patient with flexor spasms and spastic foot drop. (19893685)
2008
23
Lumbar canal stenosis presenting with acute bilateral foot drop. (16753623)
2006
24
Diagnostic challenge posed by the clinical presentation of foot drop in a patient with Hodgkin's lymphoma. (17142177)
2006
25
Segmental overlap: foot drop in S1 radiculopathy. (16523224)
2006
26
BIONic WalkAide for correcting foot drop. (16003906)
2005
27
Successful treatment of rheumatoid vasculitis-associated foot-drop with infliximab. (15801041)
2005
28
Ganglion cyst of the proximal tibiofibular joint causing foot drop-diagnostic problem of differentiating from neuritic leprosy. (16044814)
2005
29
Clinical approach to a patient presenting with foot drop. (19078736)
2004
30
MR imaging in the differential diagnosis of neurogenic foot drop. (12917113)
2003
31
Feasibility of using peroneal nerve recordings for deriving stimulation timing in a foot drop correction system. (22150915)
2003
32
ECT and bilateral foot drop. (11528323)
2001
33
Botulinum toxin A in the treatment of hemiplegic spastic foot drop--clinical and functional outcomes. (11063169)
2000
34
Bilateral foot drop as a manifestation of myasthenia gravis. (19078598)
2000
35
Postoperative gas bubble foot drop. A case report. (10025027)
1999
36
Comment: surgical reconstruction of leprotic foot-drop. (9121340)
1997
37
Non-union of ankle fractures in patients with ipsilateral foot drop. (8736315)
1995
38
Reply: 'Results of surgical procedures for the correction of foot-drop and lagophthalmus due to leprosy'. (7861931)
1994
39
Bilateral foot drop, weight loss and rectal bleeding as an acute presentation of Crohn's disease. (7831180)
1994
40
Late onset foot-drop muscular dystrophy with rimmed vacuoles. (7807161)
1994
41
Comment: 'Results of surgical procedures for the correction of foot-drop and of lagophthalmus due to leprosy'. (8231612)
1993
42
Results of surgical procedures for the correction of foot-drop and of lagophthalmus due to leprosy. (1406020)
1992
43
Fever and foot drop in a 61-year-old man. (1969505)
1990
44
Strawberry pickers' foot drop. (912290)
1977
45
Biofeedback treatment of foot drop after stroke compared with standard rehabilitation technique (part 2): effects on nerve conduction velocity and spasticity. (1247378)
1976
46
Biofeedback treatment of foot-drop after stroke compared with standard rehabilitation technique: effects on voluntary control and strength. (1137478)
1975
47
FOOT DROP IN LEPROSY. (14114051)
1964
48
Acute bilateral foot-drop in children. (14413748)
1959
49
Foot drop strap. (13238524)
1955
50
A new approach to the treatment of foot-drop. (15427056)
1950

Variations for Foot Drop

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Expression for genes affiliated with Foot Drop

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Expression patterns in normal tissues for genes affiliated with Foot Drop

Search GEO for disease gene expression data for Foot Drop.

Pathways for genes affiliated with Foot Drop

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Pathways related to Foot Drop according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.0MPZ, PMP22

Compounds for genes affiliated with Foot Drop

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Sources:
44Novoseek, 28IUPHAR, 24HMDB, 11DrugBank, 61Tocris Bioscience
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Compounds related to Foot Drop according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1curcumin449.3TNF, MPZ
2dihydroprogesterone449.2PMP22, MPZ
3ganglioside449.1PMP22, MPZ
4dihydrotestosterone44 28 24 1112.1MPZ, PMP22
5progesterone44 28 61 24 1113.0PMP22, MPZ
6aspartate448.7PMP22, MPZ
7serine448.4MPZ, PMP22, TNF

GO Terms for genes affiliated with Foot Drop

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Biological processes related to Foot Drop according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1synaptic transmissionGO:0072689.0MPZ, PMP22
2negative regulation of cell proliferationGO:0082858.8TNF, PMP22

Products for genes affiliated with Foot Drop

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Sources for Foot Drop

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet