Aliases & Classifications for Foot Drop

MalaCards integrated aliases for Foot Drop:

Name: Foot Drop 51

Summaries for Foot Drop

NINDS : 51 Foot drop describes the inability to raise the front part of the foot due to weakness or paralysis of the muscles that lift the foot. As a result, individuals with foot drop scuff their toes along the ground or bend their knees to lift their foot higher than usual to avoid the scuffing, which causes what is called a “steppage” gait. Foot drop can be unilateral (affecting one foot) or bilateral (affecting both feet). Foot drop is a symptom of an underlying problem and is either temporary or permanent, depending on the cause. Causes include: neurodegenerative disorders of the brain that cause muscular problems, such as multiple sclerosis, stroke, and cerebral palsy; motor neuron disorders such as polio, some forms of spinal muscular atrophy and amyotrophic lateral sclerosis (commonly known as Lou Gehrig’s disease); injury to the nerve roots, such as in spinal stenosis; peripheral nerve disorders such as Charcot-Marie-Tooth disease or acquired peripheral neuropathy; local compression or damage to the peroneal nerve as it passes across the fibular bone below the knee; and muscle disorders, such as muscular dystrophy or myositis.

MalaCards based summary : Foot Drop is related to charcot-marie-tooth disease, type 1e and congenital myopathy. An important gene associated with Foot Drop is ACTA1 (Actin, Alpha 1, Skeletal Muscle), and among its related pathways/superpathways are Neural Crest Differentiation and Striated Muscle Contraction. The drugs Mannitol and Ribavirin have been mentioned in the context of this disorder. Affiliated tissues include brain, bone and spinal cord, and related phenotypes are behavior/neurological and muscle

Wikipedia : 72 Foot drop is a gait abnormality in which the dropping of the forefoot happens due to weakness,... more...

Related Diseases for Foot Drop

Diseases related to Foot Drop via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 117)
id Related Disease Score Top Affiliating Genes
1 charcot-marie-tooth disease, type 1e 31.1 MPZ PMP22
2 congenital myopathy 29.6 FHL1 NEB
3 diffuse large b-cell lymphoma 28.9 MPZ PMP22
4 charcot-marie-tooth disease 11.3
5 myopathy, scapulohumeroperoneal 10.8
6 scapuloperoneal myopathy, x-linked dominant 10.8
7 cauda equina syndrome 10.8
8 welander distal myopathy, swedish type 10.8
9 dowling-degos disease 10.3 ACTA1 FHL1
10 leprosy 10.2
11 intrathoracic kidney vertebral fusion 10.2 ACTA1 NEB
12 ulerythema ophryogenesis 10.2 ACTA1 NEB
13 chitayat meunier hodgkinson syndrome 10.2 ACTA1 NEB
14 shapiro syndrome 10.2 ACTA1 NEB
15 muscular dystrophy, rigid spine, 1 10.2 ACTA1 FHL1
16 uterine corpus endometrial stromal sarcoma 10.2 ACTA1 NEB
17 neuropathy 10.1
18 cylindrical spirals myopathy 10.0 ACTA1 NEB
19 cerebritis 10.0
20 spasticity 10.0
21 schwannoma of twelfth cranial nerve 10.0 ACTA1 NEB
22 chromosome 16p13.2 deletion syndrome 9.9 MPZ PMP22
23 hereditary proximal myopathy with early respiratory failure 9.9 MPZ PMP22
24 conotruncal heart malformations 9.9 MPZ PMP22
25 congestive heart failure 9.9 MPZ PMP22
26 charcot-marie-tooth neuropathy type 4j 9.9 MPZ PMP22
27 mental retardation, x-linked, syndromic 34 9.9 MPZ PMP22
28 charcot-marie-tooth disease, type 1b 9.9 MPZ PMP22
29 charcot-marie-tooth neuropathy x 9.9 MPZ PMP22
30 lymphoma 9.9
31 neuromuscular disease 9.9
32 hypertrophic osteoarthropathy, primary, autosomal recessive 2 9.9 MPZ PMP22
33 infantile epileptic encephalopathy 9.9 MPZ PMP22
34 acute necrotizing encephalitis 9.9 MPZ PMP22
35 renal dysplasia, cystic 9.9 MPZ PMP22
36 neuropathy, recurrent, with pressure palsies 9.9 MPZ PMP22
37 thrombophilia due to antithrombin iii deficiency 9.9 MPZ PMP22
38 hypoxia 9.8 MPZ PMP22
39 pituitary adenoma, growth hormone-secreting 9.8 MPZ PMP22
40 tooth disease 9.8
41 syringomyelia 9.8
42 purpura 9.8
43 peroneal neuropathy 9.8
44 radiculopathy 9.8
45 herpes zoster 9.8
46 vasculitis 9.8
47 epidermolysis bullosa acquisita 9.8 MPZ PMP22
48 mohr-tranebjaerg syndrome 9.8 MPZ PMP22
49 neuropathy, inflammatory demyelinating 9.8 MPZ PMP22
50 dejerine-sottas disease 9.8 MPZ PMP22

Graphical network of the top 20 diseases related to Foot Drop:



Diseases related to Foot Drop

Symptoms & Phenotypes for Foot Drop

MGI Mouse Phenotypes related to Foot Drop:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.35 ACTA1 FHL1 MPZ NEB PMP22
2 muscle MP:0005369 8.92 ACTA1 FHL1 NEB PMP22

Drugs & Therapeutics for Foot Drop

Drugs for Foot Drop (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 19)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Mannitol Approved, Investigational Phase 4 69-65-8 453 6251
2
Ribavirin Approved Phase 4 36791-04-5 37542
3 Anti-Infective Agents Phase 4
4 Antimetabolites Phase 4
5 Antiviral Agents Phase 4
6
Timolol Approved Phase 3 26839-75-8 33624 5478
7 Adrenergic Agents Phase 3
8 Adrenergic Antagonists Phase 3
9 Adrenergic beta-Antagonists Phase 3
10 Anti-Arrhythmia Agents Phase 3
11 Antihypertensive Agents Phase 3
12 Neurotransmitter Agents Phase 3
13
Levobupivacaine Approved 27262-47-1 92253
14
Mepivacaine Approved, Vet_approved 96-88-8 4062
15
Menthol Approved 2216-51-5 16666
16 Anesthetics Early Phase 1
17 Complement System Proteins
18 Analgesics
19 Anesthetics, Local Early Phase 1

Interventional clinical trials:

(show all 41)

id Name Status NCT ID Phase Drugs
1 Effects of Functional Electrical Stimulation on Gait in Children With Cerebral Palsy Unknown status NCT02462018 Phase 4
2 Effect of Xiaoer Jiebiao Oral Liquid on Hand-foot-mouth Disease Recruiting NCT02328651 Phase 4 Ribavirin plus Xiao'er jiebiao oral liquid;Ribavirin
3 Evaluation of the Safety and Performance of the NESS L300 Plus System Completed NCT01237860 Phase 3
4 0.25% Bupivacaine Versus a Mixture of 0.25% Bupivacaine and 1.3 % Liposomal Bupivacaine in Patients Undergoing Tka Not yet recruiting NCT03303794 Phase 3 Exparel;0.25% bupivacaine
5 Beta Adrenergic Antagonist for the Healing of Chronic DFU Not yet recruiting NCT03282981 Phase 3 Timolol;Non biologically active gel
6 Functional Electrical Stimulation for Footdrop in Hemiparesis Completed NCT00148343 Phase 2
7 Effect of Robot-assisted Training on Foot Drop in Multiple Sclerosis Completed NCT00872053 Phase 1, Phase 2
8 Targeted Lower Extremity Joint Training Terminated NCT00765544 Phase 1, Phase 2
9 Functional Electrical Stimulation Mediated Neuroplasticity: Lower Extremity CCNMES in Stroke Unknown status NCT02199795 Phase 1
10 Pilot Study Assessing the Feasibility of Treating Foot Drop With the Neurostep™ System. Completed NCT00860210 Phase 1
11 Electrical Stimulation for Recovery of Ankle Dorsiflexion in Chronic Stroke Survivors Completed NCT01029912 Phase 1
12 Comparison of Different Treatment Methods for Gait Rehabilitation of Sub-Acute Post Stroke Patients With Dropped Foot Unknown status NCT01876030
13 Treating Foot Drop in People With Multiple Sclerosis Using Electrical Stimulation Completed NCT02123537
14 Walking With FES or AFO in People With MS With Foot Drop Completed NCT01977287
15 Evaluation of Dual Channel vs. Single Channel FES for Dropfoot Completed NCT02494323
16 Clinical Study of the L300 Versus Ankle-foot Orthosis (AFO) on Post-Stroke Subjects With Foot Drop Completed NCT01138995
17 Functional Electrical Stimulation for People With Multiple Sclerosis Who Experience Foot Drop Completed NCT01914016
18 Clinical Study to Evaluate the Implantation of the ActiGait Drop Foot Stimulator System Completed NCT01116466
19 Effect of FES Interventions on Gait Dynamics in Stroke Population Completed NCT01952613
20 Effects of Targeted Lower Extremity Joint Training on Multiple Sclerosis (MS) Gait Abnormalities Completed NCT00906737
21 WalkAide Compared to Ankle-Foot Orthosis (AFO) in Stroke Patients Completed NCT01087957
22 Parameter Changes in Functional Electrical Stimulation Completed NCT03300986
23 Tibial Nerve Versus Sciatic Nerve Block Completed NCT01415193
24 Efficacy of the WalkAide and AFOs for CVA Completed NCT00216320
25 Comparison Between Implanted Functional Electrical Stimulation and Foot Orthosis Completed NCT01415700
26 Approach to Continuous Sciatic Nerve Block for Orthopedic Procedures in Day Surgery With Two Different Techniques Completed NCT02029404
27 Interactive Exoskeleton Robot for Walking - Ankle Joint Completed NCT02471248
28 Study of Changes in the Feet With Pregnancy Completed NCT01868074
29 Effects of Weight Loss on Foot Structure and Function in Obese Adults: A Pilot Study Completed NCT01782144
30 Ankle Robot to Reduce Foot-drop in Stroke Recruiting NCT02483676
31 Multi-pad FES System for Drop Foot Treatment Recruiting NCT02729636 Early Phase 1
32 Extramembranous and Interosseous Technique of Tibialis Posterior Tendon Transfer Recruiting NCT01751503
33 Effects of Two Different Types of Ankle Foot Orthoses on Gait Outcomes in Patients With Subacute Stroke. Recruiting NCT02693834
34 Acute Nerve Decompression Versus Non-operative Treatment for Peroneal Nerve Palsy Following Primary Total Knee Arthroplasty Recruiting NCT02856958
35 Clinical Effects of Peroneal Nerve Functional Electrical Stimulation (WalkAide[R]) for Chronic Stroke Patients Recruiting NCT02897752
36 Spinal Cord Stimulation to Augment Activity Based Therapy Recruiting NCT03240601
37 Evaluation of Usability and Human Factors in the Novus System Not yet recruiting NCT02738242
38 Pairing Functional Electrical Stimulation (FES) and Volitional Effort Training Promotes Neuroplasticity and Motor Gain Not yet recruiting NCT02797886
39 Excess Opioid Disposal Following Orthopedic Foot and Ankle Surgery Not yet recruiting NCT03285061
40 The Effects of Ankle Foot Orthoses on Gait Efficiency in Children With Acute Lymphoblastic Leukemia and Foot Drop Terminated NCT01001390
41 Continuous Femoral and Tibial Nerve Blocks in TKA Patients Terminated NCT01680692 Early Phase 1 Ropivicaine

Search NIH Clinical Center for Foot Drop

Genetic Tests for Foot Drop

Anatomical Context for Foot Drop

MalaCards organs/tissues related to Foot Drop:

39
Brain, Bone, Spinal Cord, Prostate, B Cells, Myeloid, Skin

Publications for Foot Drop

Articles related to Foot Drop:

(show top 50) (show all 327)
id Title Authors Year
1
Alterations in Spectral Attributes of Surface Electromyograms after Utilization of a Foot Drop Stimulator during Post-Stroke Gait. ( 28900414 )
2017
2
Functional Outcomes Following Anterior Transfer of the Tibialis Posterior Tendon for Foot Drop Secondary to Peroneal Nerve Palsy. ( 28552040 )
2017
3
Acute Bilateral Foot Drop as a Presenting Symptom of Hemorrhagic Synovial Cyst of the Lumbar Spine. ( 28951268 )
2017
4
Intraneural ganglion cyst of the external popliteal sciatic nerve: A possible cause of foot drop. ( 28427770 )
2017
5
Differential diagnosis and recovery of acute bilateral foot drop in a patient with a history of low back pain: A case report. ( 28509608 )
2017
6
Dual lumbar bronchogenic and arachnoid cyst presenting with sciatica and left foot drop. ( 28762109 )
2017
7
Asthma, Foot Drop, and Palpable Purpura in a Young Woman. ( 28620827 )
2017
8
Transcranial Motor Evoked Potential Alarm Criteria To Predict Foot Drop Injury During Lumbosacral Surgery. ( 28614281 )
2017
9
Does a foot-drop implant improve kinetic and kinematic parameters in the foot and ankle? ( 28220261 )
2017
10
Effects of biofeedback versus switch-triggered functional electrical stimulation on sciatica-related foot drop. ( 28946515 )
2017
11
Malignant Triton tumor: a rare cause of sciatic pain and foot drop. ( 28884110 )
2017
12
Immediate effects of ankle eversion taping on dynamic and static balance of chronic stroke patients with foot drop. ( 28626316 )
2017
13
A decision support system for electrode shaping in multi-pad FES foot drop correction. ( 28673311 )
2017
14
External revascularisation for pseudochronic total occlusion of the dorsal pedis artery due to foot drop with severe diabetes mellitus. ( 28710243 )
2017
15
Functional Electrical Stimulation for Foot Drop in Multiple Sclerosis: A Systematic Review and Meta-Analysis of the Effect on Gait Speed. ( 28088382 )
2017
16
High-Stepping Cross-Country Athlete: A Unique Case of Foot Drop and a Novel Treatment Approach. ( 28902752 )
2017
17
First Case of Foot Drop Associated with Capecitabine in a Patient with Thymidylate Synthase Polymorphism. ( 28280649 )
2017
18
An Unusual Postoperative Neuropathy: Foot Drop Contralateral to the Lateral Decubitus Position. ( 27580410 )
2016
19
A Modified Approach of Percutaneous Endoscopic Lumbar Discectomy (PELD) for Far Lateral Disc Herniation at L5-S1 with Foot Drop. ( 26839673 )
2016
20
A 39-Year-Old Postpartum Woman With Foot Drop and Shortness of Breath. ( 26867857 )
2016
21
An Unusual Cause of Foot Drop: Peroneal Extraneural Ganglion Cyst. ( 27648065 )
2016
22
Preoperative motor strength and time to surgery are the most important predictors of improvement in foot drop due to degenerative lumbar disease. ( 26810531 )
2016
23
Bilateral Central Foot Drop in a Pediatric Patient. ( 27427994 )
2016
24
An Unusual Presentation of Right-Sided Sciatica with Foot Drop. ( 27217963 )
2016
25
Progressive foot drop caused by below-knee compression stocking after spinal surgery. ( 27617106 )
2016
26
Peroneal Intraneural Ganglia Formation Causing Foot Drop in Children: A Clinical Perspective. ( 26721618 )
2016
27
A Case of Alkaptonuria with Degenerative Collagenous Plaques and Foot Drop. ( 27904192 )
2016
28
"Malignant" foot drop: Enzinger epithelioid sarcoma of the common fibular nerve. ( 27061383 )
2016
29
Feasibility of Using Lokomat Combined with Functional Electrical Stimulation for the Rehabilitation of Foot Drop. ( 27990246 )
2016
30
Cat Bite: An Unusual Cause of Foot Drop. ( 26836381 )
2016
31
Foot drop of central origin: a misleading alteration of nerve conduction study. ( 26728269 )
2016
32
Simultaneous bilateral total hip arthroplasty dislocation with unilateral foot drop following closed reduction. ( 28039345 )
2016
33
Functional electrical stimulation versus ankle foot orthoses for foot-drop: A meta-analysis of orthotic effects. ( 27563700 )
2016
34
Surgical outcome of foot drop caused by common peroneal nerve injuries; is the glass half full or half empty? ( 27106843 )
2016
35
Total Hip Arthroplasty Complicated by a Gluteal Hematoma Resulting in Acute Foot Drop. ( 26966944 )
2016
36
Foot drop following closed reduction of a total hip replacement. ( 27005799 )
2016
37
Ganglion Cyst at the Proximal Tibiofibular Joint in a Patient with Painless Foot Drop. ( 27906945 )
2016
38
Foot drop following spinal anaesthesia. ( 26323747 )
2015
39
Bilateral foot-drop as predominant symptom in nebulin (NEB) gene related "core-rod" congenital myopathy. ( 26403434 )
2015
40
Gout and foot drop. ( 26453107 )
2015
41
Outcomes of the Bridle Procedure for the Treatment of Foot Drop. ( 26160388 )
2015
42
WITHDRAWN: Rehabilitation interventions for foot drop in neuromuscular disease. ( 25927103 )
2015
43
Palpable purpura with foot drop: Common presentations in an uncommon disease. ( 25821734 )
2015
44
Foot drop. ( 25918354 )
2015
45
Peroneal Stimulation for Foot Drop After Stroke: A Systematic Review. ( 26035725 )
2015
46
Endometriosis of the lumbosacral plexus: report of a case with foot drop and chronic pelvic pain. ( 25697329 )
2015
47
Popliteal Artery Pseudoaneurysm with Secondary Chronic Common Peroneal Nerve Neuropathy and Foot Drop after Total Knee Replacement. ( 26140945 )
2015
48
Spatially distributed sequential array stimulation of tibial anterior muscle for foot drop correction. ( 26737024 )
2015
49
Changes in center of pressure displacement with the use of a foot drop stimulator in individuals with stroke. ( 26003198 )
2015
50
Changes in plantar load distribution and gait pattern following foot drop correction in leprosy affected patients. ( 26665356 )
2015

Variations for Foot Drop

Expression for Foot Drop

Search GEO for disease gene expression data for Foot Drop.

Pathways for Foot Drop

Pathways related to Foot Drop according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 10.96 MPZ PMP22
2 10.48 ACTA1 NEB

GO Terms for Foot Drop

Cellular components related to Foot Drop according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 sarcomere GO:0030017 8.62 ACTA1 NEB

Biological processes related to Foot Drop according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 muscle organ development GO:0007517 9.16 FHL1 NEB
2 myelination GO:0042552 8.96 MPZ PMP22
3 muscle filament sliding GO:0030049 8.62 ACTA1 NEB

Sources for Foot Drop

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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