MCID: FTD001
MIFTS: 21

Foot Drop malady

Summaries for Foot Drop

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Sources:
43NINDS, 63Wikipedia, 32MalaCards
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NINDS:43 Foot drop describes the inability to raise the front part of the foot due to weakness or paralysis of the muscles that lift the foot. As a result, individuals with foot drop scuff their toes along the ground or bend their knees to lift their foot higher than usual to avoid the scuffing, which causes what is called a ?steppage? gait. Foot drop can be unilateral (affecting one foot) or bilateral (affecting both feet). Foot drop is a symptom of an underlying problem and is either temporary or permanent, depending on the cause. Causes include: neurodegenerative disorders of the brain that cause muscular problems, such as multiple sclerosis, stroke, and cerebral palsy; motor neuron disorders such as polio, some forms of spinal muscular atrophy and amyotrophic lateral sclerosis (commonly known as Lou Gehrig?s disease); injury to the nerve roots, such as in spinal stenosis; peripheral nerve disorders such as Charcot-Marie-Tooth disease or acquired peripheral neuropathy; local compression or damage to the peroneal nerve as it passes across the fibular bone below the knee; and muscle disorders, such as muscular dystrophy or myositis.

MalaCards: Foot Drop, also known as foot-drop, is related to neuropathy and hereditary neuropathy with liability to pressure palsies. An important gene associated with Foot Drop is MPZ (myelin protein zero), and among its related pathways is Neural Crest Differentiation. The compounds dihydroprogesterone and ganglioside have been mentioned in the context of this disorder. Affiliated tissues include bone, brain and spinal cord, and related mouse phenotype reproductive system.

Wikipedia:63 Foot drop is a gait abnormality in which the dropping of the forefoot happens due to weakness, damage to... more...

Aliases & Classifications for Foot Drop

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43NINDS, 60UMLS
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Aliases & Descriptions:

foot drop 43
foot-drop 60


Related Diseases for Foot Drop

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Foot Drop:



Diseases related to foot drop

Clinical Features for Foot Drop

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Drugs & Therapeutics for Foot Drop

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Foot Drop

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Anatomical Context for Foot Drop

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32MalaCards
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MalaCards organs/tissues related to Foot Drop:

32
Bone, Brain, Spinal cord

Animal Models for Foot Drop or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Foot Drop:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053898.5MPZ, TNF, PMP22

Publications for Foot Drop

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Genetic Variations for Foot Drop

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Expression for genes affiliated with Foot Drop

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Foot Drop

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Pathways for genes affiliated with Foot Drop

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Sources:
37NCBI BioSystems Database
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Pathways related to Foot Drop according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.0MPZ, PMP22

Compounds for genes affiliated with Foot Drop

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Sources:
44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB
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Compounds related to Foot Drop according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1dihydroprogesterone449.1MPZ, PMP22
2ganglioside449.0MPZ, PMP22
3curcumin449.0MPZ, TNF
4dihydrotestosterone44 28 11 2411.9PMP22, MPZ
5serine448.5MPZ, TNF, PMP22

GO Terms for genes affiliated with Foot Drop

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Products for genes affiliated with Foot Drop

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Foot Drop

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet