MCID: FTD001
MIFTS: 30

Foot Drop malady

Summaries for Foot Drop

Sources:
44NINDS, 64Wikipedia, 33MalaCards
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NINDS:44 Foot drop describes the inability to raise the front part of the foot due to weakness or paralysis of the muscles that lift the foot. As a result, individuals with foot drop scuff their toes along the ground or bend their knees to lift their foot higher than usual to avoid the scuffing, which causes what is called a ?steppage? gait. Foot drop can be unilateral (affecting one foot) or bilateral (affecting both feet). Foot drop is a symptom of an underlying problem and is either temporary or permanent, depending on the cause. Causes include: neurodegenerative disorders of the brain that cause muscular problems, such as multiple sclerosis, stroke, and cerebral palsy; motor neuron disorders such as polio, some forms of spinal muscular atrophy and amyotrophic lateral sclerosis (commonly known as Lou Gehrig?s disease); injury to the nerve roots, such as in spinal stenosis; peripheral nerve disorders such as Charcot-Marie-Tooth disease or acquired peripheral neuropathy; local compression or damage to the peroneal nerve as it passes across the fibular bone below the knee; and muscle disorders, such as muscular dystrophy or myositis.

MalaCards: Foot Drop, also known as foot-drop, is related to tooth disease and syringomyelia. An important gene associated with Foot Drop is MPZ (myelin protein zero), and among its related pathways is Neural Crest Differentiation. The compounds dihydroprogesterone and ganglioside have been mentioned in the context of this disorder. Affiliated tissues include skin, spinal cord and brain, and related mouse phenotype reproductive system.

Wikipedia:64 Foot drop is a gait abnormality in which the dropping of the forefoot happens due to weakness, damage to... more...

Aliases & Classifications for Foot Drop

Sources:
44NINDS, 61UMLS
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Aliases & Descriptions:

foot drop 44
foot-drop 61


Related Diseases for Foot Drop

Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Foot Drop:



Diseases related to foot drop

Clinical Features for Foot Drop

Drugs & Therapeutics for Foot Drop

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Foot Drop

Anatomical Context for Foot Drop

Sources:
33MalaCards
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MalaCards organs/tissues related to Foot Drop:

33
Skin, Spinal cord, Brain, Cortex, Prostate, Myeloid, B cells

Animal Models for Foot Drop or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Foot Drop:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053898.5MPZ, TNF, PMP22

Publications for Foot Drop

Sources:
51PubMed
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Articles related to Foot Drop:

(show top 50)    (show all 249)
idTitleAuthorsYear
1
Botox as an adjuvant to tendon transfer for foot drop. (24063800)
2013
2
Unilateral Foot Drop as an Initial Presentation of a Brain Tumor in a Child. (23456535)
2013
3
Assessment of hip abductor power in patients with foot drop: a simple and useful test to differentiate lumbar radiculopathy and peroneal neuropathy. (22805342)
2013
4
Intramuscular injection: an uncommon cause of ipsilateral foot drop. (23411983)
2013
5
Foot drop secondary to peroneal intraneural cyst arising from tibiofibular joint. (23007411)
2013
6
A sock for foot-drop: A preliminary study on two chronic stroke patients. (24107635)
2013
7
Increased size of a gas-filled intradural cyst causing acute foot drop: a case report. (23793353)
2013
8
Peroneal strength as an indicator in selecting route of tibialis posterior transfer for foot drop correction in leprosy. (24428112)
2013
9
Surgical outcome for foot drop in lumbar degenerative disease. (24353958)
2012
10
Pins and needles and unilateral foot drop: a presentation of sarcoidosis. (23087290)
2012
11
Walking training with foot drop stimulator controlled by a tilt sensor to improve walking outcomes: a randomized controlled pilot study in patients with stroke in subacute phase. (23316416)
2012
12
A clinical trial of a prototype of wireless surface fes rehabilitation system in foot drop correction. (22255573)
2011
13
Clinical features of central isolated unilateral foot drop: A case report and review of the literature. (21541007)
2011
14
Calpainopathy presenting as foot drop in a 41 year old. (20580976)
2010
15
Iatrogenic pseudoaneurysm of the superior gluteal artery presenting as pelvic mass with foot drop and sciatica: case report and review of literature. (19917559)
2010
16
On "Successful management of foot drop by nerve transfers to the deep peroneal nerve" (J Reconstr Microsurg 2008;24:419-428). (20225177)
2010
17
Long-term therapeutic and orthotic effects of a foot drop stimulator on walking performance in progressive and nonprogressive neurological disorders. (19846759)
2010
18
Foot drop caused by a brain tumor: a case report. (19673367)
2009
19
Rehabilitation interventions for foot drop in neuromuscular disease. (17443532)
2007
20
Central causes of foot drop: rare and underappreciated differential diagnoses. (17385271)
2007
21
Foot drop and plantar flexion failure determine different gait strategies in Charcot-Marie-Tooth patients. (17686557)
2007
22
Segmental overlap: foot drop in S1 radiculopathy. (16523224)
2006
23
Foot drop after spinal anesthesia in a patient with a low-lying cord. (16798451)
2006
24
Treatment of foot drop using a dynamic, non-rigid dorsiflexion foot lifter. (16138466)
2005
25
MR imaging of the lower leg versus clinical electrophysiologic examination in the differential diagnosis of neurogenic foot drop. (12917110)
2003
26
Foot drop in a marathon runner from chronic complete hamstring tear. (14627868)
2003
27
Immediate and long-term effects of ankle-foot orthosis on muscle activity during walking: a randomized study of patients with unilateral foot drop. (11833029)
2002
28
Acute foot drop caused by thrombosed epidural vein. (11534682)
2001
29
Botulinum toxin A in the treatment of hemiplegic spastic foot drop--clinical and functional outcomes. (11063169)
2000
30
Recurrent episodic foot-drop following surgery to the thigh. (18521300)
2000
31
Treatment of major depression complicated by bilateral foot drop and double incontinence with ECT. (11314881)
2000
32
Chronic complete hamstring avulsion causing foot drop. A case report. (10921653)
2000
33
Evaluation of a patient presenting with foot drop. (19078546)
1999
34
Comment: surgical reconstruction of leprotic foot-drop. (9121340)
1997
35
Bilateral foot-drop in a patient with anorexia nervosa. (9285272)
1997
36
Tibialis posterior transfer for the correction of foot drop in leprosy. Long-term outcome. (8898128)
1996
37
Surgical reconstruction of leprotic foot-drop. (8885613)
1996
38
Non-union of ankle fractures in patients with ipsilateral foot drop. (8736315)
1995
39
Foot drop in a long-distance runner. An unusual presentation of neurofibromatosis. (8065810)
1994
40
Results of surgical procedures for the correction of foot-drop and of lagophthalmus due to leprosy. (1406020)
1992
41
Cyclosporin neurotoxicity presenting as an unilateral foot drop in a renal transplant patient. (1857469)
1991
42
Tibialis posterior transfer (circumtibial route) for foot-drop deformity. (6098620)
1984
43
Anorexia nervosa presenting as foot drop. (432177)
1979
44
Biofeedback treatment of foot drop after stroke compared with standard rehabilitation technique (part 2): effects on nerve conduction velocity and spasticity. (1247378)
1976
45
Letter: Foot drop and the peroneal nerve. (950982)
1976
46
Gait analysis in stroke patients to assess treatments of foot-drop. (1084734)
1976
47
Management of foot drop in adults after permanent peroneal nerve loss. (4311866)
1969
48
Physiotherapy and foot drop corrections. (4286510)
1966
49
Peroneus longus transplant for foot drop. (13928340)
1963
50
Acute bilateral foot-drop in children. (14413748)
1959

Genetic Variations for Foot Drop

Expression for genes affiliated with Foot Drop

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Foot Drop

Search GEO for disease gene expression data for Foot Drop.

Pathways for genes affiliated with Foot Drop

Sources:
38NCBI BioSystems Database
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Pathways related to Foot Drop according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.0MPZ, PMP22

Compounds for genes affiliated with Foot Drop

Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 24HMDB
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Compounds related to Foot Drop according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1dihydroprogesterone459.1MPZ, PMP22
2ganglioside459.0MPZ, PMP22
3curcumin459.0MPZ, TNF
4dihydrotestosterone45 29 11 2411.9PMP22, MPZ
5serine458.5MPZ, TNF, PMP22

GO Terms for genes affiliated with Foot Drop

Products for genes affiliated with Foot Drop

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Sources for Foot Drop

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet