MCID: FTD001
MIFTS: 37

Foot Drop malady

Summaries for Foot Drop

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Sources:
45NINDS, 66Wikipedia, 34MalaCards
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NINDS:45 Foot drop describes the inability to raise the front part of the foot due to weakness or paralysis of the muscles that lift the foot. As a result, individuals with foot drop scuff their toes along the ground or bend their knees to lift their foot higher than usual to avoid the scuffing, which causes what is called a ?steppage? gait. Foot drop can be unilateral (affecting one foot) or bilateral (affecting both feet). Foot drop is a symptom of an underlying problem and is either temporary or permanent, depending on the cause. Causes include: neurodegenerative disorders of the brain that cause muscular problems, such as multiple sclerosis, stroke, and cerebral palsy; motor neuron disorders such as polio, some forms of spinal muscular atrophy and amyotrophic lateral sclerosis (commonly known as Lou Gehrig?s disease); injury to the nerve roots, such as in spinal stenosis; peripheral nerve disorders such as Charcot-Marie-Tooth disease or acquired peripheral neuropathy; local compression or damage to the peroneal nerve as it passes across the fibular bone below the knee; and muscle disorders, such as muscular dystrophy or myositis.

MalaCards: Foot Drop, also known as foot-drop, is related to neuropathy and hereditary neuropathy with liability to pressure palsies. An important gene associated with Foot Drop is MPZ (myelin protein zero), and among its related pathways is Neural Crest Differentiation. The compounds curcumin and dihydroprogesterone have been mentioned in the context of this disorder. Affiliated tissues include brain, bone and spinal cord, and related mouse phenotypes are reproductive system and nervous system.

Wikipedia:66 Foot drop is a gait abnormality in which the dropping of the forefoot happens due to weakness,... more...

Aliases & Classifications for Foot Drop

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Sources:
45NINDS, 63UMLS
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Aliases & Descriptions:

foot drop 45
foot-drop 63


Related Diseases for Foot Drop

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18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Foot Drop:



Diseases related to foot drop

Symptoms for Foot Drop

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Drugs & Therapeutics for Foot Drop

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Foot Drop

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Anatomical Context for Foot Drop

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34MalaCards
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MalaCards organs/tissues related to Foot Drop:

34
Brain, Bone, Spinal cord, Prostate, Cortex, Skin, Testes, Myeloid, B cells

Animal Models for Foot Drop or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Foot Drop:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053898.5MPZ, TNF, PMP22
2MP:00036318.5MPZ, TNF, PMP22
3MP:00053868.4PMP22, TNF, MPZ
4MP:00053848.2PMP22, TNF, MPZ

Publications for Foot Drop

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53PubMed
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Articles related to Foot Drop:

(show top 50)    (show all 239)
idTitleAuthorsYear
1
Botox as an adjuvant to tendon transfer for foot drop. (24063800)
2013
2
Unilateral Foot Drop as an Initial Presentation of a Brain Tumor in a Child. (23456535)
2013
3
Kinetics and kinematics after the Bridle procedure for treatment of traumatic foot drop. (23684087)
2013
4
Spastic foot-drop as an isolated manifestation of neurocysticercosis. (23008377)
2012
5
Solitary lumbar osteochondroma presenting with foot-drop: a case report. (22665015)
2012
6
A clinical trial of a prototype of wireless surface fes rehabilitation system in foot drop correction. (22255573)
2011
7
Maternal sacral fracture during delivery causing foot drop. (21978815)
2011
8
Clinical features of central isolated unilateral foot drop: A case report and review of the literature. (21541007)
2011
9
Lumbar subdural hematoma from intracranial subarachnoid hemorrhage presenting with bilateral foot drop: case report. (21311278)
2011
10
A rare reason of foot drop caused by primary diffuse large b-cell lymphoma of the sciatic nerve: case report. (19415174)
2010
11
A bilateral foot drop due to neuroschistosomiasis. (20127348)
2010
12
A foot-drop case. (20440657)
2010
13
Foot drop--an unusual presentation of exertional compartment syndrome. (19423978)
2009
14
Interosseous nerve transfers for tibialis anterior muscle paralysis (foot drop): a human cadaver-based feasibility study. (19048462)
2009
15
Giant popliteal aneurysm with deep vein thrombosis, foot drop and arteriomegali. (21686392)
2009
16
Foot-drop: an unusual complaint in Henoch-SchAPnlein purpura. (18773224)
2009
17
Foot drop of sudden onset caused by acute hematoma in the lumbar ligamentum flavum: a case report and review of the literature. (18628701)
2008
18
Neuropathic pain and foot drop related to nerve injury after short duration surgery and caudal analgesia. (18716505)
2008
19
Delayed diagnosis of brain tumor in a patient with flexor spasms and spastic foot drop. (19893685)
2008
20
Foot drop: where, why and what to do? (18502948)
2008
21
Bilateral foot drop after intestinal surgery: peroneal neuropathy unabated in elderly patients. (17979916)
2007
22
Lumbar canal stenosis presenting with acute bilateral foot drop. (16753623)
2006
23
Diagnostic challenge posed by the clinical presentation of foot drop in a patient with Hodgkin's lymphoma. (17142177)
2006
24
Segmental overlap: foot drop in S1 radiculopathy. (16523224)
2006
25
BIONic WalkAide for correcting foot drop. (16003906)
2005
26
Successful treatment of rheumatoid vasculitis-associated foot-drop with infliximab. (15801041)
2005
27
Ganglion cyst of the proximal tibiofibular joint causing foot drop-diagnostic problem of differentiating from neuritic leprosy. (16044814)
2005
28
Clinical approach to a patient presenting with foot drop. (19078736)
2004
29
MR imaging in the differential diagnosis of neurogenic foot drop. (12917113)
2003
30
Feasibility of using peroneal nerve recordings for deriving stimulation timing in a foot drop correction system. (22150915)
2003
31
ECT and bilateral foot drop. (11528323)
2001
32
Botulinum toxin A in the treatment of hemiplegic spastic foot drop--clinical and functional outcomes. (11063169)
2000
33
Bilateral foot drop as a manifestation of myasthenia gravis. (19078598)
2000
34
Postoperative gas bubble foot drop. A case report. (10025027)
1999
35
Comment: surgical reconstruction of leprotic foot-drop. (9121340)
1997
36
Non-union of ankle fractures in patients with ipsilateral foot drop. (8736315)
1995
37
Reply: 'Results of surgical procedures for the correction of foot-drop and lagophthalmus due to leprosy'. (7861931)
1994
38
Late onset foot-drop muscular dystrophy with rimmed vacuoles. (7807161)
1994
39
Comment: 'Results of surgical procedures for the correction of foot-drop and of lagophthalmus due to leprosy'. (8231612)
1993
40
Results of surgical procedures for the correction of foot-drop and of lagophthalmus due to leprosy. (1406020)
1992
41
Reversal of foot drop in sciatic nerve endometriosis. (1744654)
1991
42
Fever and foot drop in a 61-year-old man. (1969505)
1990
43
Strawberry pickers' foot drop. (912290)
1977
44
Biofeedback treatment of foot drop after stroke compared with standard rehabilitation technique (part 2): effects on nerve conduction velocity and spasticity. (1247378)
1976
45
Biofeedback treatment of foot-drop after stroke compared with standard rehabilitation technique: effects on voluntary control and strength. (1137478)
1975
46
FOOT DROP IN LEPROSY. (14114051)
1964
47
Acute bilateral foot-drop in children. (14413748)
1959
48
Foot drop strap. (13238524)
1955
49
A new approach to the treatment of foot-drop. (15427056)
1950
50
Trichiniasis presenting with foot-drop and facial palsy. (18920136)
1948

Variations for Foot Drop

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Expression for genes affiliated with Foot Drop

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Foot Drop

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Pathways for genes affiliated with Foot Drop

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51PathCards, 39NCBI BioSystems Database
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Pathways related to Foot Drop according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.0MPZ, PMP22

Compounds for genes affiliated with Foot Drop

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Sources:
46Novoseek, 30IUPHAR, 25HMDB, 12DrugBank, 62Tocris Bioscience
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Compounds related to Foot Drop according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1curcumin469.3TNF, MPZ
2dihydroprogesterone469.2PMP22, MPZ
3ganglioside469.1PMP22, MPZ
4dihydrotestosterone46 30 25 1212.1MPZ, PMP22
5progesterone46 30 62 25 1213.0PMP22, MPZ
6aspartate468.7PMP22, MPZ
7serine468.4MPZ, PMP22, TNF

GO Terms for genes affiliated with Foot Drop

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17Gene Ontology
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Biological processes related to Foot Drop according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1synaptic transmissionGO:0072689.0MPZ, PMP22
2negative regulation of cell proliferationGO:0082858.8TNF, PMP22

Products for genes affiliated with Foot Drop

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Sources for Foot Drop

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet