Aliases & Classifications for Foot Drop

MalaCards integrated aliases for Foot Drop:

Name: Foot Drop 50

Summaries for Foot Drop

NINDS : 50 Foot drop describes the inability to raise the front part of the foot due to weakness or paralysis of the muscles that lift the foot. As a result, individuals with foot drop scuff their toes along the ground or bend their knees to lift their foot higher than usual to avoid the scuffing, which causes what is called a “steppage” gait. Foot drop can be unilateral (affecting one foot) or bilateral (affecting both feet). Foot drop is a symptom of an underlying problem and is either temporary or permanent, depending on the cause. Causes include: neurodegenerative disorders of the brain that cause muscular problems, such as multiple sclerosis, stroke, and cerebral palsy; motor neuron disorders such as polio, some forms of spinal muscular atrophy and amyotrophic lateral sclerosis (commonly known as Lou Gehrig’s disease); injury to the nerve roots, such as in spinal stenosis; peripheral nerve disorders such as Charcot-Marie-Tooth disease or acquired peripheral neuropathy; local compression or damage to the peroneal nerve as it passes across the fibular bone below the knee; and muscle disorders, such as muscular dystrophy or myositis.

MalaCards based summary : Foot Drop is related to charcot-marie-tooth disease and deafness and hereditary neuropathy with liability to pressure palsy. An important gene associated with Foot Drop is ACTA1 (Actin, Alpha 1, Skeletal Muscle), and among its related pathways/superpathways are Neural Crest Differentiation and Striated Muscle Contraction. The drugs Bupivacaine and Anesthetics have been mentioned in the context of this disorder. Affiliated tissues include brain, bone and spinal cord, and related phenotypes are behavior/neurological and muscle

Wikipedia : 72 Foot drop is a gait abnormality in which the dropping of the forefoot happens due to weakness,... more...

Related Diseases for Foot Drop

Diseases related to Foot Drop via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 127)
# Related Disease Score Top Affiliating Genes
1 charcot-marie-tooth disease and deafness 31.1 MPZ PMP22
2 hereditary neuropathy with liability to pressure palsy 29.6 MPZ PMP22
3 myopathy, congenital 29.6 ACTA1 NEB
4 neuropathy, hereditary, with liability to pressure palsies 29.6 MPZ PMP22
5 neuromuscular disease 29.5 MPZ PMP22
6 hereditary neuropathies 29.5 MPZ PMP22
7 polyneuropathy 29.1 MPZ PMP22
8 tooth disease 28.9 MPZ PMP22
9 myopathy 28.7 ACTA1 FHL1 NEB
10 charcot-marie-tooth disease 11.4
11 myopathy, scapulohumeroperoneal 11.0
12 cauda equina syndrome 11.0
13 scapuloperoneal myopathy, x-linked dominant 11.0
14 welander distal myopathy, swedish type 11.0
15 leprosy 3 10.3
16 neuropathy 10.2
17 scapuloperoneal myopathy 10.1 ACTA1 FHL1
18 episodic pain syndrome, familial, 1 10.1
19 intermediate congenital nemaline myopathy 10.1 ACTA1 NEB
20 typical congenital nemaline myopathy 10.1 ACTA1 NEB
21 childhood-onset nemaline myopathy 10.1 ACTA1 NEB
22 severe congenital nemaline myopathy 10.1 ACTA1 NEB
23 rigid spine muscular dystrophy 1 10.1 ACTA1 FHL1
24 congenital structural myopathy 10.1 ACTA1 NEB
25 cerebritis 10.1
26 spasticity 10.1
27 multiple sclerosis 10.1
28 reducing body myopathy 10.0 FHL1 NEB
29 lymphoma 10.0
30 nemaline myopathy 9.9 ACTA1 NEB
31 purpura 9.9
32 peroneal neuropathy 9.9
33 radiculopathy 9.9
34 stroke, ischemic 9.9
35 streptococcal group a invasive disease 9.9
36 herpes zoster 9.9
37 vasculitis 9.9
38 syringomyelia 9.9
39 charcot-marie-tooth neuropathy type 1 9.9 MPZ PMP22
40 charcot-marie-tooth disease, demyelinating, type 1f 9.9 MPZ PMP22
41 congenital hypomyelination neuropathy 9.9 MPZ PMP22
42 charcot-marie-tooth disease, demyelinating, type 1b 9.9 MPZ PMP22
43 charcot-marie-tooth disease, axonal, type 2b 9.9 MPZ PMP22
44 roussy-levy hereditary areflexic dystasia 9.9 MPZ PMP22
45 motor peripheral neuropathy 9.9 MPZ PMP22
46 charcot-marie-tooth disease, demyelinating, type 1a 9.9 MPZ PMP22
47 chronic inflammatory demyelinating polyradiculoneuropathy 9.8 MPZ PMP22
48 charcot-marie-tooth disease, demyelinating, type 1d 9.8 MPZ PMP22
49 polyradiculoneuropathy 9.8 MPZ PMP22
50 paraneoplastic syndromes 9.8

Graphical network of the top 20 diseases related to Foot Drop:



Diseases related to Foot Drop

Symptoms & Phenotypes for Foot Drop

MGI Mouse Phenotypes related to Foot Drop:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.35 ACTA1 FHL1 MPZ NEB PMP22
2 muscle MP:0005369 8.92 ACTA1 FHL1 NEB PMP22

Drugs & Therapeutics for Foot Drop

Drugs for Foot Drop (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bupivacaine Approved, Investigational Phase 3 38396-39-3, 2180-92-9 2474
2 Anesthetics Phase 3,Early Phase 1
3 Central Nervous System Depressants Phase 3
4 Anesthetics, Local Phase 3,Early Phase 1
5 Peripheral Nervous System Agents Phase 3
6
Menthol Approved 2216-51-5 16666
7
Mepivacaine Approved, Vet_approved 96-88-8 4062
8
Levobupivacaine Approved, Investigational 27262-47-1 92253
9 Complement System Proteins

Interventional clinical trials:

(show all 39)

# Name Status NCT ID Phase Drugs
1 Effects of Functional Electrical Stimulation on Gait in Children With Cerebral Palsy Unknown status NCT02462018 Phase 4
2 Evaluation of the Safety and Performance of the NESS L300 Plus System Completed NCT01237860 Phase 3
3 0.25% Bupivacaine Versus a Mixture of 0.25% Bupivacaine and 1.3 % Liposomal Bupivacaine in Patients Undergoing Tka Not yet recruiting NCT03303794 Phase 3 Exparel;0.25% bupivacaine
4 Functional Electrical Stimulation for Footdrop in Hemiparesis Completed NCT00148343 Phase 2
5 Effect of Robot-assisted Training on Foot Drop in Multiple Sclerosis Completed NCT00872053 Phase 1, Phase 2
6 Targeted Lower Extremity Joint Training Terminated NCT00765544 Phase 1, Phase 2
7 Pilot Study Assessing the Feasibility of Treating Foot Drop With the Neurostep™ System. Completed NCT00860210 Phase 1
8 Evaluation of Usability and Human Factors in the Novus System Unknown status NCT02738242
9 Comparison of Different Treatment Methods for Gait Rehabilitation of Sub-Acute Post Stroke Patients With Dropped Foot Unknown status NCT01876030
10 Treating Foot Drop in People With Multiple Sclerosis Using Electrical Stimulation Completed NCT02123537
11 Walking With FES or AFO in People With MS With Foot Drop Completed NCT01977287
12 Evaluation of Dual Channel vs. Single Channel FES for Dropfoot Completed NCT02494323
13 Clinical Study of the L300 Versus Ankle-foot Orthosis (AFO) on Post-Stroke Subjects With Foot Drop Completed NCT01138995
14 Functional Electrical Stimulation for People With Multiple Sclerosis Who Experience Foot Drop Completed NCT01914016
15 Clinical Study to Evaluate the Implantation of the ActiGait Drop Foot Stimulator System Completed NCT01116466
16 Implanted Drop Foot Stimulator for Hemiparetic Patients Completed NCT03447717
17 Effect of FES Interventions on Gait Dynamics in Stroke Population Completed NCT01952613
18 Functional Electrical Stimulation Mediated Neuroplasticity: Lower Extremity CCNMES in Stroke Completed NCT02199795
19 Effects of Targeted Lower Extremity Joint Training on Multiple Sclerosis (MS) Gait Abnormalities Completed NCT00906737
20 WalkAide Compared to Ankle-Foot Orthosis (AFO) in Stroke Patients Completed NCT01087957
21 Parameter Changes in Functional Electrical Stimulation Completed NCT03300986
22 Tibial Nerve Versus Sciatic Nerve Block Completed NCT01415193
23 Efficacy of the WalkAide and AFOs for CVA Completed NCT00216320
24 Comparison Between Implanted Functional Electrical Stimulation and Foot Orthosis Completed NCT01415700
25 Approach to Continuous Sciatic Nerve Block for Orthopedic Procedures in Day Surgery With Two Different Techniques Completed NCT02029404
26 Interactive Exoskeleton Robot for Walking - Ankle Joint Completed NCT02471248
27 Electrical Stimulation for Recovery of Ankle Dorsiflexion in Chronic Stroke Survivors Completed NCT01029912
28 Ankle Robot to Reduce Foot Drop in Stroke Recruiting NCT02483676
29 Multi-pad FES System for Drop Foot Treatment Recruiting NCT02729636 Early Phase 1
30 Extramembranous and Interosseous Technique of Tibialis Posterior Tendon Transfer Recruiting NCT01751503
31 Effects of Two Different Types of Ankle Foot Orthoses on Gait Outcomes in Patients With Subacute Stroke. Recruiting NCT02693834
32 Acute Nerve Decompression Versus Non-operative Treatment for Peroneal Nerve Palsy Following Primary Total Knee Arthroplasty Recruiting NCT02856958
33 Spinal Cord Stimulation to Augment Activity Based Therapy Recruiting NCT03240601
34 Clinical Effects of Peroneal Nerve Functional Electrical Stimulation (WalkAide[R]) for Chronic Stroke Patients Active, not recruiting NCT02897752
35 Pairing Functional Electrical Stimulation (FES) and Volitional Effort Training Promotes Neuroplasticity and Motor Gain Not yet recruiting NCT02797886
36 The Effects of FES in a Variety of Walking Conditions in People With MS Not yet recruiting NCT03410498
37 Functional Electrical Stimulation During Walking in Cerebral Palsy Not yet recruiting NCT03440632
38 The Effects of Ankle Foot Orthoses on Gait Efficiency in Children With Acute Lymphoblastic Leukemia and Foot Drop Terminated NCT01001390
39 Continuous Femoral and Tibial Nerve Blocks in TKA Patients Terminated NCT01680692 Early Phase 1 Ropivicaine

Search NIH Clinical Center for Foot Drop

Genetic Tests for Foot Drop

Anatomical Context for Foot Drop

MalaCards organs/tissues related to Foot Drop:

38
Brain, Bone, Spinal Cord, Prostate, B Cells, Myeloid, Skin

Publications for Foot Drop

Articles related to Foot Drop:

(show top 50) (show all 338)
# Title Authors Year
1
Irreversible Foot Drop as a Consequence of Neglected Knee Pain in an Adolescent with a Peroneal Intraneural Ganglion Cyst. ( 29309980 )
2018
2
Risk Factors Analysis for Foot Drop Associated with Lumbar Disc Herniation: An Analysis of 236 Patients. ( 29223521 )
2018
3
Acute Bilateral Isolated Foot Drop: Changing the Paradigm in Management of Degenerative Spine Surgery with Percutaneous Endoscopy. ( 29191530 )
2018
4
Chiari malformation type 1 presenting as unilateral progressive foot drop: a case report and review of literature. ( 29415676 )
2018
5
Functional electrical stimulation and ankle foot orthoses provide equivalent therapeutic effects on foot drop: A meta-analysis providing direction for future research. ( 29227525 )
2018
6
Functional Outcomes Following Anterior Transfer of the Tibialis Posterior Tendon for Foot Drop Secondary to Peroneal Nerve Palsy. ( 28552040 )
2017
7
High-Stepping Cross-Country Athlete: A Unique Case of Foot Drop and a Novel Treatment Approach. ( 28902752 )
2017
8
Walking measures to evaluate assistive technology for foot drop in multiple sclerosis: A systematic review of psychometric properties. ( 29304511 )
2017
9
Functional Electrical Stimulation for Foot Drop in Multiple Sclerosis: A Systematic Review and Meta-Analysis of the Effect on Gait Speed. ( 28088382 )
2017
10
A decision support system for electrode shaping in multi-pad FES foot drop correction. ( 28673311 )
2017
11
Malignant Triton tumor: a rare cause of sciatic pain and foot drop. ( 28884110 )
2017
12
An Unexpected Reason for Isolated Foot Drop: Acute Stroke. ( 29142581 )
2017
13
Immediate effects of ankle eversion taping on dynamic and static balance of chronic stroke patients with foot drop. ( 28626316 )
2017
14
Intraneural ganglion cyst of the external popliteal sciatic nerve: A possible cause of foot drop. ( 28427770 )
2017
15
First Case of Foot Drop Associated with Capecitabine in a Patient with Thymidylate Synthase Polymorphism. ( 28280649 )
2017
16
Dual lumbar bronchogenic and arachnoid cyst presenting with sciatica and left foot drop. ( 28762109 )
2017
17
Acute Bilateral Foot Drop as a Presenting Symptom of Hemorrhagic Synovial Cyst of the Lumbar Spine. ( 28951268 )
2017
18
Flexor Hallucis Longus Transfer for Foot Drop without Functioning Tibialis Posterior. ( 29351531 )
2017
19
Alterations in Spectral Attributes of Surface Electromyograms after Utilization of a Foot Drop Stimulator during Post-Stroke Gait. ( 28900414 )
2017
20
Peripheral Neuropathy Due to Recreational Use of Nitrous Oxide Presenting After an Ankle Sprain With Foot Drop. ( 29120005 )
2017
21
Effects of biofeedback versus switch-triggered functional electrical stimulation on sciatica-related foot drop. ( 28946515 )
2017
22
Asthma, Foot Drop, and Palpable Purpura in a Young Woman. ( 28620827 )
2017
23
The effect of newly designed multi joint ankle foot orthosis on the gait and dynamic balance of stroke patients with foot drop. ( 29200619 )
2017
24
Transcranial Motor Evoked Potential Alarm Criteria To Predict Foot Drop Injury During Lumbosacral Surgery. ( 28614281 )
2017
25
Gait Improvements After Peroneal or Tibial Nerve Transfer in Patients with Foot Drop: A Retrospective Study. ( 29018508 )
2017
26
Differential diagnosis and recovery of acute bilateral foot drop in a patient with a history of low back pain: A case report. ( 28509608 )
2017
27
External revascularisation for pseudochronic total occlusion of the dorsal pedis artery due to foot drop with severe diabetes mellitus. ( 28710243 )
2017
28
Does a foot-drop implant improve kinetic and kinematic parameters in the foot and ankle? ( 28220261 )
2017
29
Peroneal Intraneural Ganglia Formation Causing Foot Drop in Children: A Clinical Perspective. ( 26721618 )
2016
30
Feasibility of Using Lokomat Combined with Functional Electrical Stimulation for the Rehabilitation of Foot Drop. ( 27990246 )
2016
31
An Unusual Cause of Foot Drop: Peroneal Extraneural Ganglion Cyst. ( 27648065 )
2016
32
Preoperative motor strength and time to surgery are the most important predictors of improvement in foot drop due to degenerative lumbar disease. ( 26810531 )
2016
33
Cat Bite: An Unusual Cause of Foot Drop. ( 26836381 )
2016
34
A Modified Approach of Percutaneous Endoscopic Lumbar Discectomy (PELD) for Far Lateral Disc Herniation at L5-S1 with Foot Drop. ( 26839673 )
2016
35
Total Hip Arthroplasty Complicated by a Gluteal Hematoma Resulting in Acute Foot Drop. ( 26966944 )
2016
36
Bilateral Central Foot Drop in a Pediatric Patient. ( 27427994 )
2016
37
Ganglion Cyst at the Proximal Tibiofibular Joint in a Patient with Painless Foot Drop. ( 27906945 )
2016
38
Foot drop of central origin: a misleading alteration of nerve conduction study. ( 26728269 )
2016
39
Functional electrical stimulation versus ankle foot orthoses for foot-drop: A meta-analysis of orthotic effects. ( 27563700 )
2016
40
An Unusual Postoperative Neuropathy: Foot Drop Contralateral to the Lateral Decubitus Position. ( 27580410 )
2016
41
Progressive foot drop caused by below-knee compression stocking after spinal surgery. ( 27617106 )
2016
42
A 39-Year-Old Postpartum Woman With Foot Drop and Shortness of Breath. ( 26867857 )
2016
43
Foot drop following closed reduction of a total hip replacement. ( 27005799 )
2016
44
"Malignant" foot drop: Enzinger epithelioid sarcoma of the common fibular nerve. ( 27061383 )
2016
45
Surgical outcome of foot drop caused by common peroneal nerve injuries; is the glass half full or half empty? ( 27106843 )
2016
46
Simultaneous bilateral total hip arthroplasty dislocation with unilateral foot drop following closed reduction. ( 28039345 )
2016
47
A Case of Alkaptonuria with Degenerative Collagenous Plaques and Foot Drop. ( 27904192 )
2016
48
An Unusual Presentation of Right-Sided Sciatica with Foot Drop. ( 27217963 )
2016
49
WITHDRAWN: Rehabilitation interventions for foot drop in neuromuscular disease. ( 25927103 )
2015
50
Effects of Lower-Leg Kinesiology Taping on Balance Ability in Stroke Patients with Foot Drop. ( 26579200 )
2015

Variations for Foot Drop

Expression for Foot Drop

Search GEO for disease gene expression data for Foot Drop.

Pathways for Foot Drop

Pathways related to Foot Drop according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.96 MPZ PMP22
2 10.48 ACTA1 NEB

GO Terms for Foot Drop

Cellular components related to Foot Drop according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sarcomere GO:0030017 8.62 ACTA1 NEB

Biological processes related to Foot Drop according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 muscle organ development GO:0007517 9.16 FHL1 NEB
2 myelination GO:0042552 8.96 MPZ PMP22
3 muscle filament sliding GO:0030049 8.62 ACTA1 NEB

Sources for Foot Drop

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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