Aliases & Classifications for Foot Drop

Aliases & Descriptions for Foot Drop:

Name: Foot Drop 51

Summaries for Foot Drop

NINDS : 51 Foot drop describes the inability to raise the front part of the foot due to weakness or paralysis of the muscles that lift the foot. As a result, individuals with foot drop scuff their toes along the ground or bend their knees to lift their foot higher than usual to avoid the scuffing, which causes what is called a “steppage” gait. Foot drop can be unilateral (affecting one foot) or bilateral (affecting both feet). Foot drop is a symptom of an underlying problem and is either temporary or permanent, depending on the cause. Causes include: neurodegenerative disorders of the brain that cause muscular problems, such as multiple sclerosis, stroke, and cerebral palsy; motor neuron disorders such as polio, some forms of spinal muscular atrophy and amyotrophic lateral sclerosis (commonly known as Lou Gehrig’s disease); injury to the nerve roots, such as in spinal stenosis; peripheral nerve disorders such as Charcot-Marie-Tooth disease or acquired peripheral neuropathy; local compression or damage to the peroneal nerve as it passes across the fibular bone below the knee; and muscle disorders, such as muscular dystrophy or myositis.

MalaCards based summary : Foot Drop is related to charcot-marie-tooth disease, type 1e and congenital myopathy. An important gene associated with Foot Drop is MPZ (Myelin Protein Zero), and among its related pathways/superpathways are Neural Crest Differentiation and Striated Muscle Contraction. The drugs Hyaluronic acid and Acetylcholine have been mentioned in the context of this disorder. Affiliated tissues include brain, bone and spinal cord, and related phenotypes are behavior/neurological and muscle

Wikipedia : 71 Foot drop is a gait abnormality in which the dropping of the forefoot happens due to weakness,... more...

Related Diseases for Foot Drop

Diseases related to Foot Drop via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 116)
id Related Disease Score Top Affiliating Genes
1 charcot-marie-tooth disease, type 1e 31.4 MPZ PMP22
2 congenital myopathy 29.6 FHL1 NEB
3 myopathy 29.4 ACTA1 NEB
4 charcot-marie-tooth disease 11.3
5 scapuloperoneal myopathy, x-linked dominant 10.8
6 myopathy, scapulohumeroperoneal 10.8
7 cauda equina syndrome 10.8
8 leprosy 10.2
9 neuropathy 10.1
10 hereditary type 2 neuropathy 10.1 MPZ PMP22
11 craniorachischisis 10.1 MPZ PMP22
12 chrna1-related congenital myasthenic syndrome 10.1 MPZ PMP22
13 surfactant metabolism dysfunction, pulmonary, 2 10.1 MPZ PMP22
14 pneumonic plague 10.1 MPZ PMP22
15 deafness, autosomal recessive 76 10.1 MPZ PMP22
16 classic galactosemia and clinical variant galactosemia 10.1 MPZ PMP22
17 hypertrophic osteoarthropathy, primary, autosomal recessive 2 10.1 MPZ PMP22
18 neuropathy, inflammatory demyelinating 10.1 MPZ PMP22
19 acute sanguinous otitis media 10.1 MPZ PMP22
20 dejerine-sottas disease 10.1 MPZ PMP22
21 nephrolithiasis, uric acid 10.1 MPZ PMP22
22 chkb-related muscle diseases 10.1 MPZ PMP22
23 infantile epileptic encephalopathy 10.1 MPZ PMP22
24 potocki-lupski syndrome 10.1 MPZ PMP22
25 von economo's disease 10.1 MPZ PMP22
26 pituitary adenoma, prolactin-secreting 10.1 MPZ PMP22
27 mohr-tranebjaerg syndrome 10.1 MPZ PMP22
28 non-gestational choriocarcinoma 10.1 MPZ PMP22
29 korsakoff's amnesic syndrome 10.1 MPZ PMP22
30 neuropathy, congenital hypomyelinating 10.1 MPZ PMP22
31 choreatic disease 10.0 MPZ PMP22
32 status epilepticus 10.0 MPZ PMP22
33 senile angioma 10.0 MPZ PMP22
34 thrombophilia due to antithrombin iii deficiency 10.0 MPZ PMP22
35 uterine ligament serous adenocarcinoma 10.0 MPZ PMP22
36 iodine antenatal infection 10.0 ACTA1 NEB
37 short limbs abnormal face congenital heart disease 10.0 ACTA1 NEB
38 chondrodysplasia calcificans metaphysealis 10.0 ACTA1 NEB
39 undifferentiated pleomorphic sarcoma 10.0 ACTA1 NEB
40 dilated cardiomyopathy 10.0 MPZ PMP22
41 spasticity 10.0
42 cerebritis 10.0
43 conotruncal heart malformations 10.0 MPZ PMP22
44 dowling-degos disease 10.0 ACTA1 FHL1
45 phototoxic dermatitis 10.0 MPZ PMP22
46 muscular dystrophy, rigid spine, 1 10.0 ACTA1 FHL1
47 microcephaly and chorioretinopathy 1 10.0 ACTA1 NEB
48 white piedra 9.9 MPZ PMP22
49 substance-induced psychosis 9.9 MPZ PMP22
50 hypoglossal nerve neoplasm 9.9 ACTA1 NEB

Graphical network of the top 20 diseases related to Foot Drop:



Diseases related to Foot Drop

Symptoms & Phenotypes for Foot Drop

MGI Mouse Phenotypes related to Foot Drop:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.35 ACTA1 FHL1 MPZ NEB PMP22
2 muscle MP:0005369 8.92 ACTA1 FHL1 NEB PMP22

Drugs & Therapeutics for Foot Drop

Drugs for Foot Drop (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 94)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hyaluronic acid Approved, Vet_approved Phase 4 9004-61-9 53477741 24759
2
Acetylcholine Approved Phase 4 51-84-3 187
3
Bimatoprost Approved, Investigational Phase 4 155206-00-1 5311027
4
Mannitol Approved, Investigational Phase 4 69-65-8 453 6251
5
Ribavirin Approved Phase 4 36791-04-5 37542
6
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2 59-30-3 6037
7
Thiamine Approved, Nutraceutical, Vet_approved Phase 4 59-43-8 1130
8 Neurotransmitter Agents Phase 4,Phase 2,Phase 3
9 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3
10 Vitamin B Complex Phase 4,Phase 3,Phase 2
11 Pharmaceutical Solutions Phase 4
12 Vitamins Phase 4,Phase 2
13 Antihypertensive Agents Phase 4,Phase 2,Phase 3
14 Cholinergic Agents Phase 4
15 Adjuvants, Immunologic Phase 4
16 Neuromuscular Agents Phase 4
17 Ophthalmic Solutions Phase 4
18 Viscosupplements Phase 4
19 abobotulinumtoxinA Phase 4
20 incobotulinumtoxinA Phase 4
21 onabotulinumtoxinA Phase 4
22 Protective Agents Phase 4,Phase 2
23 Antimetabolites Phase 4,Phase 3
24 Botulinum Toxins Phase 4
25 Botulinum Toxins, Type A Phase 4
26 Trace Elements Phase 4,Phase 2
27 Anti-Infective Agents Phase 4
28 Micronutrients Phase 4,Phase 2
29 Antiviral Agents Phase 4
30 Folate Nutraceutical Phase 4,Phase 3,Phase 2
31 Vitamin B9 Nutraceutical Phase 4,Phase 3,Phase 2
32 Thiamin Nutraceutical Phase 4
33
Ondansetron Approved Phase 2, Phase 3 99614-02-5 4595
34
Methotrexate Approved Phase 3 1959-05-2, 59-05-2 126941
35
Tofacitinib Approved, Investigational Phase 3 477600-75-2
36
leucovorin Approved, Nutraceutical Phase 3 58-05-9 54575, 6560146 143
37
Serotonin Phase 2, Phase 3 50-67-9 5202
38 Serotonin Agents Phase 2, Phase 3
39 Serotonin Antagonists Phase 2, Phase 3
40 Gastrointestinal Agents Phase 2, Phase 3
41 Dermatologic Agents Phase 2, Phase 3
42 Tranquilizing Agents Phase 2, Phase 3
43 Anesthetics Phase 2, Phase 3,Early Phase 1
44 Anti-Anxiety Agents Phase 2, Phase 3
45 Antiemetics Phase 2, Phase 3
46 Psychotropic Drugs Phase 2, Phase 3
47 Antipsychotic Agents Phase 2, Phase 3
48 Autonomic Agents Phase 2, Phase 3
49 Central Nervous System Depressants Phase 2, Phase 3
50 Antipruritics Phase 2, Phase 3

Interventional clinical trials:

(show top 50) (show all 54)
id Name Status NCT ID Phase
1 Patient Satisfaction Study of Combined Facial Treatment With BOTOX® Cosmetic, JUVÉDERM® and LATISSE® (HARMONY Study) Completed NCT02176356 Phase 4
2 Effect of Xiaoer Jiebiao Oral Liquid on Hand-foot-mouth Disease Recruiting NCT02328651 Phase 4
3 Thiamin Deficiency in Obese Thai Children Recruiting NCT02464865 Phase 4
4 Effects of Functional Electrical Stimulation on Gait in Children With Cerebral Palsy Not yet recruiting NCT02462018 Phase 4
5 Intravenous Ondansetron to Attenuate the Hypotensive, Bradycardic Response to Spinal Anesthesia in Healthy Parturients Unknown status NCT01414777 Phase 2, Phase 3
6 Evaluation of the Safety and Performance of the NESS L300 Plus System Completed NCT01237860 Phase 3
7 Comparing The Effectiveness And Safety Of 2 Doses Of An Experimental Drug, CP-690,550, To Methotrexate (MTX) In Patients With Rheumatoid Arthritis Who Have Not Previously Received MTX Completed NCT01039688 Phase 3
8 Functional Electrical Stimulation for Footdrop in Hemiparesis Completed NCT00148343 Phase 2
9 Effect of Robot-assisted Training on Foot Drop in Multiple Sclerosis Completed NCT00872053 Phase 1, Phase 2
10 Extracorporeal Shockwave Treatment for Chronic Soft Tissue Wounds Completed NCT00545896 Phase 2
11 The Role of Cytokines on Growth Hormone Suppression in Premenopausal Women With Rheumatoid Arthritis and the Effect of Treatment With Etanercept Completed NCT00034060 Phase 2
12 A Phase I/II Double-blind Safety and Efficacy Evaluation of Nowarta110 in Patients With Plantar Warts Completed NCT02338336 Phase 1, Phase 2
13 Essential Oils for Enhancing QOL in ASD Recruiting NCT02543203 Phase 2
14 Marched Pair Study Conventional Doxorubicin(DOX) Versus Pegylated Liposomal Doxorubicin(PLD) Neoadjuvant Chemotherapy Recruiting NCT02953184 Phase 2
15 Targeted Lower Extremity Joint Training Terminated NCT00765544 Phase 1, Phase 2
16 Functional Electrical Stimulation Mediated Neuroplasticity: Lower Extremity CCNMES in Stroke Unknown status NCT02199795 Phase 1
17 Pilot Study Assessing the Feasibility of Treating Foot Drop With the Neurostep™ System. Completed NCT00860210 Phase 1
18 Electrical Stimulation for Recovery of Ankle Dorsiflexion in Chronic Stroke Survivors Completed NCT01029912 Phase 1
19 Comparison of Different Treatment Methods for Gait Rehabilitation of Sub-Acute Post Stroke Patients With Dropped Foot Unknown status NCT01876030
20 Effect of FES Interventions on Gait Dynamics in Stroke Population Unknown status NCT01952613
21 A Clinical Trial to Evaluate the Effectiveness and Safety of Xiyanping Injection in the Treatment of Mild Type of Hand, Foot, and Mouth Disease Unknown status NCT01182025
22 Eccentric Exercise for Chronic Mid-portion Achilles Tendinopathy Unknown status NCT01225497
23 Treating Foot Drop in People With Multiple Sclerosis Using Electrical Stimulation Completed NCT02123537
24 Walking With FES or AFO in People With MS With Foot Drop Completed NCT01977287
25 Evaluation of Dual Channel vs. Single Channel FES for Dropfoot Completed NCT02494323
26 Clinical Study of the L300 Versus Ankle-foot Orthosis (AFO) on Post-Stroke Subjects With Foot Drop Completed NCT01138995
27 Functional Electrical Stimulation for People With Multiple Sclerosis Who Experience Foot Drop Completed NCT01914016
28 Clinical Study to Evaluate the Implantation of the ActiGait Drop Foot Stimulator System Completed NCT01116466
29 Effects of Targeted Lower Extremity Joint Training on Multiple Sclerosis (MS) Gait Abnormalities Completed NCT00906737
30 WalkAide Compared to Ankle-Foot Orthosis (AFO) in Stroke Patients Completed NCT01087957
31 Tibial Nerve Versus Sciatic Nerve Block Completed NCT01415193
32 Efficacy of the WalkAide and AFOs for CVA Completed NCT00216320
33 Comparison Between Implanted Functional Electrical Stimulation and Foot Orthosis Completed NCT01415700
34 Approach to Continuous Sciatic Nerve Block for Orthopedic Procedures in Day Surgery With Two Different Techniques Completed NCT02029404
35 Study of Changes in the Feet With Pregnancy Completed NCT01868074
36 Effects of Weight Loss on Foot Structure and Function in Obese Adults: A Pilot Study Completed NCT01782144
37 Treatment of Painful Diabetic Neuropathy With Photon Stimulation Completed NCT00539175
38 PAHA Study: Psychological Active and Healthy Ageing Completed NCT01966562
39 Ankle Robot to Reduce Foot-drop in Stroke Recruiting NCT02483676
40 Multi-pad FES System for Drop Foot Treatment Recruiting NCT02729636 Early Phase 1
41 Extramembranous and Interosseous Technique of Tibialis Posterior Tendon Transfer Recruiting NCT01751503
42 Effects of Two Different Types of Ankle Foot Orthoses on Gait Outcomes in Patients With Subacute Stroke. Recruiting NCT02693834
43 Acute Nerve Decompression Versus Non-operative Treatment for Peroneal Nerve Palsy Following Primary Total Knee Arthroplasty Recruiting NCT02856958
44 Clinical Effects of Peroneal Nerve Functional Electrical Stimulation (WalkAide[R]) for Chronic Stroke Patients Recruiting NCT02897752
45 Interactive Exoskeleton Robot for Walking - Ankle Joint Recruiting NCT02471248
46 Pathological Basis of MRI Signal Changes in Multiple Sclerosis Recruiting NCT02659956
47 Do Simple Running Technique Changes Reduce Pain and Change Injury Causing Mechanics Recruiting NCT03067545
48 Effects on Pes Planus Exercise Training Mixed With Play on Pre-school Children Recruiting NCT03151538
49 Chromosome 18 Clinical Research Center Recruiting NCT00227253
50 Evaluation of Usability and Human Factors in the Novus System Not yet recruiting NCT02738242

Search NIH Clinical Center for Foot Drop

Genetic Tests for Foot Drop

Anatomical Context for Foot Drop

MalaCards organs/tissues related to Foot Drop:

39
Brain, Bone, Spinal Cord, Prostate, B Cells, Myeloid, Skin

Publications for Foot Drop

Articles related to Foot Drop:

(show top 50) (show all 307)
id Title Authors Year
1
An Unusual Presentation of Right-Sided Sciatica with Foot Drop. ( 27217963 )
2016
2
Preoperative motor strength and time to surgery are the most important predictors of improvement in foot drop due to degenerative lumbar disease. ( 26810531 )
2016
3
An Unusual Cause of Foot Drop: Peroneal Extraneural Ganglion Cyst. ( 27648065 )
2016
4
Foot drop following closed reduction of a total hip replacement. ( 27005799 )
2016
5
Progressive foot drop caused by below-knee compression stocking after spinal surgery. ( 27617106 )
2016
6
Foot drop of central origin: a misleading alteration of nerve conduction study. ( 26728269 )
2016
7
A 39-Year-Old Postpartum Woman With Foot Drop and Shortness of Breath. ( 26867857 )
2016
8
Cat Bite: An Unusual Cause of Foot Drop. ( 26836381 )
2016
9
Functional electrical stimulation versus ankle foot orthoses for foot-drop: A meta-analysis of orthotic effects. ( 27563700 )
2016
10
An Unusual Postoperative Neuropathy: Foot Drop Contralateral to the Lateral Decubitus Position. ( 27580410 )
2016
11
Surgical outcome of foot drop caused by common peroneal nerve injuries; is the glass half full or half empty? ( 27106843 )
2016
12
A Modified Approach of Percutaneous Endoscopic Lumbar Discectomy (PELD) for Far Lateral Disc Herniation at L5-S1 with Foot Drop. ( 26839673 )
2016
13
A Case of Alkaptonuria with Degenerative Collagenous Plaques and Foot Drop. ( 27904192 )
2016
14
Bilateral Central Foot Drop in a Pediatric Patient. ( 27427994 )
2016
15
Peroneal Intraneural Ganglia Formation Causing Foot Drop in Children: A Clinical Perspective. ( 26721618 )
2016
16
"Malignant" foot drop: Enzinger epithelioid sarcoma of the common fibular nerve. ( 27061383 )
2016
17
Total Hip Arthroplasty Complicated by a Gluteal Hematoma Resulting in Acute Foot Drop. ( 26966944 )
2016
18
Popliteal Artery Pseudoaneurysm with Secondary Chronic Common Peroneal Nerve Neuropathy and Foot Drop after Total Knee Replacement. ( 26140945 )
2015
19
Gout and foot drop. ( 26453107 )
2015
20
Endometriosis of the lumbosacral plexus: report of a case with foot drop and chronic pelvic pain. ( 25697329 )
2015
21
The impact of walking speed on the effects of functional electrical stimulation for foot drop in people with multiple sclerosis. ( 25826047 )
2015
22
Misunderstanding of foot drop in a patient with charcot-marie-tooth disease and lumbar disk herniation. ( 25932299 )
2015
23
WITHDRAWN: Rehabilitation interventions for foot drop in neuromuscular disease. ( 25927103 )
2015
24
Changes in center of pressure displacement with the use of a foot drop stimulator in individuals with stroke. ( 26003198 )
2015
25
Changes in plantar load distribution and gait pattern following foot drop correction in leprosy affected patients. ( 26665356 )
2015
26
Palpable purpura with foot drop: Common presentations in an uncommon disease. ( 25821734 )
2015
27
Foot drop following spinal anaesthesia. ( 26323747 )
2015
28
Acute bilateral isolated foot drop: Report of two cases. ( 25972945 )
2015
29
Bilateral foot-drop as predominant symptom in nebulin (NEB) gene related "core-rod" congenital myopathy. ( 26403434 )
2015
30
Effects of Lower-Leg Kinesiology Taping on Balance Ability in Stroke Patients with Foot Drop. ( 26579200 )
2015
31
Spatially distributed sequential array stimulation of tibial anterior muscle for foot drop correction. ( 26737024 )
2015
32
WITHDRAWN: Rehabilitation interventions for foot drop in neuromuscular disease. ( 25687881 )
2015
33
Statin-induced bilateral foot drop in a case of hypothyroidism. ( 26425013 )
2015
34
A basic study on quantitative evaluation of 3-dimensional foot contact with an inertial sensor for FES foot drop correction. ( 26737826 )
2015
35
Peroneal Stimulation for Foot Drop After Stroke: A Systematic Review. ( 26035725 )
2015
36
Sonographic evaluation of common peroneal neuropathy in patients with foot drop. ( 25792587 )
2015
37
Isolated Painless Foot Drop due to Cerebral Infarction Mimicking Lumbar Radiculopathy: A Case Report. ( 26512287 )
2015
38
Conversion Disorder; an Unusual Etiology of Unilateral Foot Drop. ( 26179836 )
2015
39
Clinical reasoning: a 51-year-old woman with acute foot drop. ( 25688156 )
2015
40
Foot drop. ( 25918354 )
2015
41
Outcomes of the Bridle Procedure for the Treatment of Foot Drop. ( 26160388 )
2015
42
Posterior tibial tendon transfer improves function for foot drop after knee dislocation. ( 24566891 )
2014
43
Managing spastic foot drop after stroke. ( 24628965 )
2014
44
EMG of the tibialis anterior demonstrates a training effect after utilization of a foot drop stimulator. ( 24990033 )
2014
45
Cerebral infarction presenting with unilateral isolated foot drop. ( 25368770 )
2014
46
Comparison of walking energy cost between an anterior and a posterior ankle-foot orthosis in people with foot drop. ( 24953375 )
2014
47
Poststroke muscle architectural parameters of the tibialis anterior and the potential implications for rehabilitation of foot drop. ( 25133011 )
2014
48
Bilateral Ankle and Subtalar Joint Fusion Secondary to Guillain BarrAc-Induced Foot Drop. ( 25128306 )
2014
49
Comparative analysis and quantitative evaluation of ankle-foot orthoses for foot drop in chronic hemiparetic patients. ( 25184801 )
2014
50
The unique case of foot drop secondary to a large ovarian cyst. ( 24447226 )
2014

Variations for Foot Drop

Expression for Foot Drop

Search GEO for disease gene expression data for Foot Drop.

Pathways for Foot Drop

Pathways related to Foot Drop according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 10.96 MPZ PMP22
2 10.48 ACTA1 NEB

GO Terms for Foot Drop

Cellular components related to Foot Drop according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 sarcomere GO:0030017 8.62 ACTA1 NEB

Biological processes related to Foot Drop according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 muscle organ development GO:0007517 9.16 FHL1 NEB
2 myelination GO:0042552 8.96 MPZ PMP22
3 muscle filament sliding GO:0030049 8.62 ACTA1 NEB

Sources for Foot Drop

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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