Aliases & Classifications for Fournier Gangrene

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Aliases & Descriptions for Fournier Gangrene:

Name: Fournier Gangrene 45 65
 
Fournier's Gangrene 45


Classifications:



Summaries for Fournier Gangrene

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Wikipedia:68 Fournier gangrene is a type of necrotizing fasciitis or gangrene usually affecting the perineum. It... more...

MalaCards based summary: Fournier Gangrene, also known as fournier's gangrene, is related to hemorrhoid and fibrous histiocytoma. An important gene associated with Fournier Gangrene is SERPINC1 (Serpin Peptidase Inhibitor, Clade C (Antithrombin), Member 1), and among its related pathways are FOXA2 and FOXA3 transcription factor networks and Response to elevated platelet cytosolic Ca2+. Affiliated tissues include spinal cord, skin and appendix, and related mouse phenotypes are hematopoietic system and immune system.

Related Diseases for Fournier Gangrene

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Diseases related to Fournier Gangrene via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 195)
idRelated DiseaseScoreTop Affiliating Genes
1hemorrhoid30.6CD40LG, SERPINC1
2fibrous histiocytoma30.4ALB, CD40LG
3spinal cord injury10.4
4necrotizing fasciitis10.4
5fasciitis10.4
6colorectal cancer10.2
7alcohol abuse10.2
8urethritis10.2
9rectosigmoid cancer10.2
10adenocarcinoma10.2
11histiocytoma10.2
12nephrotic syndrome10.2
13peritonitis10.2
14sarcoma10.2
15hyper ige syndrome10.2
16pleomorphic malignant fibrous histiocytoma10.2
17spinocerebellar atrophy10.2F2, SERPINC1
18hypoprothrombinemia10.2F2, SERPINC1
19aggressive systemic mastocytosis10.2F2, SERPINC1
20maxillary sinus cholesteatoma10.2F2, SERPINC1
21mitral valve insufficiency10.2F2, SERPINC1
22louse-borne relapsing fever10.2F2, SERPINC1
23sesame syndrome10.2F2, SERPINC1
24breast angiosarcoma10.2F2, SERPINC1
25retinal cancer10.2F2, SERPINC1
26budd-chiari syndrome10.2F2, SERPINC1
27conversion disorder10.2F2, SERPINC1
28retinitis10.2F2, SERPINC1
29larynx squamous papilloma10.2CD40LG, SERPINC1
30protein c deficiency10.2F2, SERPINC1
31calpainopathy10.2ALB, SERPINC1
32appendicitis10.2F2, SERPINC1
33rocky mountain spotted fever10.2CD40LG, SERPINC1
34disuse amblyopia10.2F2, SERPINC1
35islet cell tumor10.2F2, SERPINC1
36non-classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency10.2ALB, F2
37acute myocarditis10.2CD40LG, F2
38liver failure acute infantile10.2CD40LG, F2
39abnormal pupillary function10.2ALB, F2
40retinitis pigmentosa10.2F2, SERPINC1
41cushing's syndrome10.2ALB, F2
42small intestine diverticulitis10.2ALB, F2
43bernard-soulier syndrome, type a210.2F2, SERPINC1
44localized anterior staphyloma10.2CD40LG, SERPINC1
45fungal esophagitis10.2F2, SERPINC1
46myofascial pain syndrome10.2ALB, F2
47axial osteomalacia10.2ALB, F2
48brucella canis brucellosis10.2CD40LG, F2
49acute lymphoblastic leukemia, childhood10.1ALB, F2
50klippel-feil syndrome10.1ALB, F2

Graphical network of the top 20 diseases related to Fournier Gangrene:



Diseases related to fournier gangrene

Symptoms for Fournier Gangrene

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Drugs & Therapeutics for Fournier Gangrene

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Drugs for Fournier Gangrene (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1Rho(D) Immune GlobulinPhase 2198
2Immunoglobulins, IntravenousPhase 2203
3Immunoglobulin GPhase 2167
4
Daptomycinapproved, investigational82103060-53-316129629
Synonyms:
103060-53-3
AKOS005146218
C12013
C72H101N17O26
CHEBI:600103
CHEMBL508162
Cidecin
Cubicin
Cubicin (TN)
D01080
DAPTOMYCIN
Dapcin
Daptomicina
Daptomicina [Spanish]
Daptomycin
Daptomycin (JAN/USAN/INN)
Daptomycin [USAN:INN:BAN]
Daptomycine
 
Daptomycine [French]
Daptomycinum
Daptomycinum [Latin]
Deptomycin
LS-171846
LY 146032
LY-146032
LY146032
MK-3009
MolPort-003-846-138
N-Decanoyl-L-tryptophyl-L-asparaginyl-L-aspartyl-L-threonylglycyl-L-ornithyl-L-aspartyl-D-alanyl-L-aspartylglycyl-D-seryl-threo-3-methyl-L-glutamyl-3-anthraniloyl-L-alanine epsilon1-lactone
N-decanoyl-L-tryptophyl-D-asparaginyl-L-aspartyl-L-threonylglycyl-L-ornithyl-L-aspartyl-D-alanyl-L-aspartylglycyl-D-seryl-threo-3-methyl-L-glutamyl-3-anthraniloyl-L-alanine 1.13-3.4-lactone
N-decanoyl-L-tryptophyl-D-asparaginyl-L-aspartyl-L-threonylglycyl-L-ornithyl-L-aspartyl-D-alanyl-L-aspartylglycyl-D-seryl-threo-3-methyl-L-glutamyl-3-anthraniloyl-L-alanine epsilon(1)-lactone
N-decanoyl-L-tryptophyl-D-asparaginyl-N-[(3S,6S,9R,15S,18R,21S,24S,30S,31R)-3-[2-(2-aminophenyl)-2-oxoethyl]-24-(3-aminopropyl)-15,21-bis(carboxymethyl)-6-[(2R)-1-carboxypropan-2-yl]-9-(hydroxymethyl)-18,31-dimethyl-2,5,8,11,14,17,20,23,26,29-decaoxo-1-oxa-4,7,10,13,16,19,22,25,28-nonaazacyclohentriacontan-30-yl]-L-alpha-asparagine
N-decanoyl-L-tryptophyl-L-asparaginyl-N-[(3S,6S,9R,15S,18R,21S,24S,30S,31R)-3-[2-(2-aminophenyl)-2-oxoethyl]-24-(3-aminopropyl)-15,21-bis(carboxymethyl)-6-[(2R)-1-carboxypropan-2-yl]-9-(hydroxymethyl)-18,31-dimethyl-2,5,8,11,14,17,20,23,26,29-decaoxo-1-ox
N-decanoyl-L-tryptophyl-L-asparaginyl-N-[(3S,6S,9R,15S,18R,21S,24S,30S,31R)-3-[2-(2-aminophenyl)-2-oxoethyl]-24-(3-aminopropyl)-15,21-bis(carboxymethyl)-6-[(2R)-1-carboxypropan-2-yl]-9-(hydroxymethyl)-18,31-dimethyl-2,5,8,11,14,17,20,23,26,29-decaoxo-1-oxa-4,7,10,13,16,19,22,25,28-nonaazacyclohentriacontan-30-yl]-L-alpha-asparagine
UNII-NWQ5N31VKK
daptomycin
nchembio.184-comp5

Interventional clinical trials:

idNameStatusNCT IDPhase
1Phase III Efficacy and Safety Study of AB103 in the Treatment of Patients With Necrotizing Soft Tissue InfectionsRecruitingNCT02469857Phase 3
2Immunoglobulin for Necrotizing Soft Tissue Infections: a Randomised Controlled TrialRecruitingNCT02111161Phase 2
3Biomarkers in Patients With Flesh-eating Bacterial InfectionsCompletedNCT02180906
4Daptomycin for the Treatment of Severe Necrotizing Soft-Tissue InfectionsCompletedNCT00261807
5Exploratory Study of Raised Serum Lactate as a Marker of Necrotizing FasciitisCompletedNCT01739959
6Modulation of Biomarkers in Patients With Flesh-eating Bacterial Infections After With Hyperbaric Oxygen TreatmentRecruitingNCT02501382

Search NIH Clinical Center for Fournier Gangrene

Genetic Tests for Fournier Gangrene

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Anatomical Context for Fournier Gangrene

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MalaCards organs/tissues related to Fournier Gangrene:

33
Spinal cord, Skin, Appendix, Testes, Colon

Animal Models for Fournier Gangrene or affiliated genes

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MGI Mouse Phenotypes related to Fournier Gangrene:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053977.6CD40LG, F2, F3, F8, SERPINC1
2MP:00053877.3CD40LG, F2, F3, F8, SERPINC1
3MP:00107687.2ALB, CD40LG, F2, F3, F8, SERPINC1
4MP:00053767.0ALB, CD40LG, F2, F3, F8, SERPINC1

Publications for Fournier Gangrene

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Articles related to Fournier Gangrene:

(show top 50)    (show all 66)
idTitleAuthorsYear
1
Fournier Gangrene in Pregnancy. (25774932)
2015
2
Reconstruction of Defects After Fournier Gangrene: A Systematic Review. (26171090)
2015
3
Temporary Relocation of the Testes in Anteromedial Thigh Pouches Facilitates Delayed Primary Scrotal Wound Closure in Fournier Gangrene With Extensive Loss of Scrotal Skin-Experience With 12 Cases. (25785387)
2015
4
Xenogenic (porcine) acellular dermal matrix promotes growth of granulation tissues in the wound healing of Fournier gangrene. (25569072)
2015
5
Unusual foreign body in the sigmoid colon, chronic alcohol abuse, and Fournier gangrene: a case report. (25878494)
2015
6
Negative pressure wound therapy applied before and after split-thickness skin graft helps healing of Fournier gangrene: a case report (CARE-Compliant). (25654376)
2015
7
A Contemporary Analysis of Fournier Gangrene Using the National Surgical Quality Improvement Program. (25770725)
2015
8
FDG PET/CT Images Demonstrating Fournier Gangrene With Bilateral Pelvic Muscle Extension in a Patient With Recurrent Rectosigmoid Cancer. (23510891)
2014
9
Enterostomy can decrease the mortality of patients with Fournier gangrene. (24976731)
2014
10
Solitary Candida albicans Infection Causing Fournier Gangrene and Review of Fungal Etiologies. (25009452)
2014
11
Emergence of Antibiotic-Resistant Bacteria in Patients with Fournier Gangrene. (25215467)
2014
12
Bilateral adrenal haemorrhage associated with heparin-induced thrombocytopaenia during treatment of Fournier gangrene. (25315802)
2014
13
Fournier gangrene as a manifestation of undiagnosed metastatic perforated colorectal cancer. (23438275)
2013
14
Emergency radiology eponyms: part 2--Naclerio's V sign to Fournier gangrene. (23065070)
2013
15
2-octyl-cyanoacrylate glue for fixation of STSG in genitourinary tissue defects due to Fournier gangrene: a preliminary trial. (23720107)
2013
16
Fournier gangrene: an unusual presentation involving the bulbous urethra and forming free gas in the urinary bladder. (21820264)
2013
17
Prognostic factors in Fournier gangrene. (22726562)
2012
18
Fournier gangrene and unexpected death. (22471925)
2012
19
A clinical case of Fournier gangrene. (23025122)
2012
20
Neonatal scrotal wall necrotizing fasciitis (Fournier gangrene): a case report. (22151925)
2011
21
The emergency computed tomography as important modality for early diagnosis of Fournier gangrene. (20951534)
2011
22
Is intensive multimodality therapy the best treatment for fournier gangrene? Evaluation of clinical outcome and survival rate of 41 patients. (21943303)
2011
23
Fournier gangrene: our approach and patients. (21849758)
2011
24
Pleomorphic malignant fibrous histiocytoma/undifferentiated high-grade pleomorphic sarcoma of the scrotum in a patient presenting as fournier gangrene: a case report. (20505510)
2010
25
Extended retroperitoneal necrotizing fasciitis with genital involvement, resembling fournier gangrene. (20583955)
2010
26
F-18 fluorodeoxyglucose PET in Fournier gangrene. (20631519)
2010
27
Fournier gangrene. (20411094)
2010
28
Fournier gangrene: rapid diagnosis with bedside ultrasonography. (21073782)
2010
29
Fournier gangrene: a review of 41 patients and strategies for reconstruction. (20407363)
2010
30
The beneficial role of patient-controlled epidural analgesia in a patient with fournier gangrene. (19282721)
2009
31
A short history of Fournier gangrene. (19221264)
2009
32
Fournier gangrene presenting in a patient with undiagnosed rectal adenocarcinoma: a case report. (20062653)
2009
33
Fournier gangrene: role of imaging. (18349455)
2008
34
A 12-month-old infant with Fournier gangrene associated with varicella. (18090105)
2007
35
Death resulting from fournier gangrene secondary to thrombosis of very large hemorrhoids: report of a case. (17846838)
2007
36
Fournier gangrene. (17034687)
2006
37
Scrotal reconstruction following fournier gangrene using the medial circumflex femoral artery perforator flap. (16929205)
2006
38
Fournier gangrene. Approaches to diagnosis and treatment. (16830027)
2006
39
Anal tumor diagnosed after the recovery of Fournier gangrene. (16642420)
2006
40
Fournier gangrene in spinal cord injury: a case report. (16572560)
2006
41
Fournier gangrene in spinal cord injury: a case report. (15889700)
2005
42
Group C streptococcal sepsis complicating Fournier gangrene. (16217985)
2005
43
Case 54: Fournier gangrene. (12511678)
2003
44
Fournier gangrene associated with Crohn disease. (10852429)
2000
45
Picture of the month. Fournier gangrene. (8954006)
1996
46
US case of the day. Fournier gangrene. (7855351)
1994
47
Fournier gangrene caused by a perforated retroperitoneal appendix: CT demonstration. (1898809)
1991
48
Gracilis musculocutaneous flap scrotal reconstruction after Fournier gangrene. (3765234)
1986
49
Radiological features of Fournier gangrene. (7280228)
1981
50
Urology-epitomes of progress: recent experience in the management of fournier gangrene. (18748404)
1979

Variations for Fournier Gangrene

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Expression for genes affiliated with Fournier Gangrene

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Search GEO for disease gene expression data for Fournier Gangrene.

Pathways for genes affiliated with Fournier Gangrene

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GO Terms for genes affiliated with Fournier Gangrene

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Cellular components related to Fournier Gangrene according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:00310939.6ALB, F8
2blood microparticleGO:00725629.5ALB, F2, SERPINC1
3extracellular spaceGO:00056157.1ALB, CD40LG, F2, F3, F8, SERPINC1

Biological processes related to Fournier Gangrene according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1response to woundingGO:00096119.8F2, F3
2blood coagulation, intrinsic pathwayGO:00075979.7F2, F8
3acute-phase responseGO:00069539.6F2, F8
4platelet degranulationGO:00025769.5ALB, F8
5platelet activationGO:00301688.2ALB, CD40LG, F2, F8
6blood coagulationGO:00075967.3ALB, F2, F3, F8, SERPINC1

Molecular functions related to Fournier Gangrene according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1copper ion bindingGO:00055079.1ALB, F8

Sources for Fournier Gangrene

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet