MCID: FRN014
MIFTS: 30

Fournier Gangrene malady

Summaries for Fournier Gangrene

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63Wikipedia, 32MalaCards
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Wikipedia:63 Fournier gangrene is a type of necrotizing infection or gangrene usually affecting the perineum. more...

MalaCards: Fournier Gangrene, also known as fournier's gangrene, is related to nephrotic syndrome and necrotizing fasciitis. An important gene associated with Fournier Gangrene is SERPINC1 (serpin peptidase inhibitor, clade C (antithrombin), member 1), and among its related pathways are Gamma-carboxylation, transport, and amino-terminal cleavage of proteins and Selected targets of C/EBPalpha. The compounds warfarin and dextran sulfate have been mentioned in the context of this disorder. Related mouse phenotypes are hematopoietic system and mortality/aging.

Aliases & Classifications for Fournier Gangrene

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42NIH Rare Diseases, 60UMLS
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Aliases & Descriptions:

fournier gangrene 42 60
fournier's gangrene 42


Related Diseases for Fournier Gangrene

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Fournier Gangrene:



Diseases related to fournier gangrene

Clinical Features for Fournier Gangrene

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Drugs & Therapeutics for Fournier Gangrene

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Fournier Gangrene

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Anatomical Context for Fournier Gangrene

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Animal Models for Fournier Gangrene or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Fournier Gangrene:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053977.5F8, IGHE, CD40LG, F3, F2, SERPINC1
2MP:00107687.3ALB, SERPINC1, F2, F3, CD40LG, F8
3MP:00053877.3F8, IGHE, CD40LG, F3, F2, SERPINC1
4MP:00053766.7ALB, F8, IGHE, CD40LG, F3, F2

Publications for Fournier Gangrene

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Genetic Variations for Fournier Gangrene

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Expression for genes affiliated with Fournier Gangrene

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Fournier Gangrene

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Pathways for genes affiliated with Fournier Gangrene

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53Reactome, 49PharmGKB, 12EMD Millipore, 37NCBI BioSystems Database, 51QIAGEN, 29KEGG, 52R&D Systems
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Compounds for genes affiliated with Fournier Gangrene

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44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 28IUPHAR, 59Tocris Bioscience
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Compounds related to Fournier Gangrene according to GeneCards/GeneDecks:

(show top 50)    (show all 137)
idCompoundScoreTop Affiliating Genes
1warfarin44 49 11 2413.5SERPINC1
2dextran sulfate4410.4CD40LG
3heparin44 28 11 2413.1F8, CD40LG
4certoparin449.4F3, F2, SERPINC1
5inogatran449.4F2, SERPINC1, F3
6ecarin449.3F3, F2, SERPINC1
7polybrene449.3F2, SERPINC1, F3
8spectrozyme449.3F3, SERPINC1, F2
9danaparoid449.3F2, F3, SERPINC1
10rivaroxaban44 1110.3SERPINC1, F2, F3
11organon449.3SERPINC1, F3, F2
12ximelagatran44 1110.3F3, F2, SERPINC1
13heparinoids449.2SERPINC1, F2, F3
14vitamin k144 2410.2SERPINC1, F2, F3
15kaolin449.2F3, F2, F8
16fondaparinux449.2F2, SERPINC1, F3
17silicone449.2CD40LG, SERPINC1, IGHE
18bivalirudin44 1110.2F3, F2, SERPINC1
19aprotinin44 1110.1SERPINC1, F3, IGHE
20argatroban44 1110.1F3, F2, SERPINC1
21protamine sulfate449.0SERPINC1, F2, F3
22ppack449.0F3, F2, SERPINC1, CD40LG
23tirofiban44 1110.0CD40LG, F3, F2, SERPINC1
24abciximab44 1110.0CD40LG, SERPINC1, F2, F3
25clopidogrel49 44 11 2411.9SERPINC1, F2, F3, CD40LG
26tranexamic acid44 119.9F8, SERPINC1, F2, F3
27ristocetin448.9F3, F8, F2, SERPINC1
28desmopressin44 59 28 1111.9F3, F2, F8, SERPINC1
29dextran 70448.9F2, ALB, F3
30protamine448.8F2, F3, IGHE, SERPINC1
31sulfamethoxazole44 49 1110.7CD40LG, ALB, IGHE
32acenocoumarol44 49 1110.7ALB, F2, F3
33epsilon aminocaproic acid448.7F2, F3, SERPINC1
34ivig448.6CD40LG, IGHE, F8, ALB
35hepaplastin448.6SERPINC1, ALB, F2, F3
36phenprocoumon44 49 1110.6ALB, SERPINC1, F2, F3
37hirudin448.5F8, SERPINC1, CD40LG, F3, F2
38aspirin44 49 28 2411.4CD40LG, SERPINC1, F3, F2, F8
39kininogen448.4SERPINC1, ALB, F3, F2
40polyethylene glycol448.3CD40LG, ALB, F8, SERPINC1, F2
41polysaccharide448.3SERPINC1, F3, F8, CD40LG, IGHE
42epinephrine44 11 2410.2F3, F2, F8, IGHE, CD40LG
43hydroxyethyl starch448.1F2, F8, ALB, SERPINC1, F3
44aspartate448.1ALB, F2, IGHE, F8, CD40LG
45homocysteine44 249.1F8, F2, SERPINC1, ALB, F3
46citrate448.1ALB, SERPINC1, F2, F8, F3
47fibrinogen447.7F3, SERPINC1, ALB, CD40LG, F8, F2
48lactate447.6ALB, F2, CD40LG, IGHE, F8
49creatinine447.2F2, ALB, F8, IGHE, CD40LG, F3
50alanine447.2ALB, SERPINC1, F8, IGHE, F2, F3

GO Terms for genes affiliated with Fournier Gangrene

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16Gene Ontology
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Cellular components related to Fournier Gangrene according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:0310939.2ALB, F8
2extracellular regionGO:0055767.5F8, IGHE, F2, SERPINC1, ALB
3extracellular spaceGO:0056157.2ALB, SERPINC1, F2, F3, CD40LG, F8

Biological processes related to Fournier Gangrene according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1acute-phase responseGO:0069539.5F2, F8
2blood coagulation, intrinsic pathwayGO:0075979.2F2, F8
3platelet activationGO:0301688.2F8, CD40LG, F2, ALB
4blood coagulationGO:0075967.7ALB, SERPINC1, F2, F3, F8

Products for genes affiliated with Fournier Gangrene

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  • Antibodies
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Sources for Fournier Gangrene

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet