Aliases & Classifications for Fournier Gangrene

MalaCards integrated aliases for Fournier Gangrene:

Name: Fournier Gangrene 49 69
Fournier's Gangrene 49

Classifications:



External Ids:

UMLS 69 C0238419

Summaries for Fournier Gangrene

NIH Rare Diseases : 49 Fournier gangrene refers to the death of body tissue of the genitals and/or perineum. Signs and symptoms of the condition include genital pain, tenderness, redness, and swelling with a rapid progression to gangrene. Although the condition can affect men and women of all ages, it is most commonly diagnosed in adult males. Most cases of Fournier gangrene are caused by an infection in the genital area or urinary tract. People with impaired immunity (i.e. due to diabetes or HIV) have an increased susceptibility to the condition. Treatment generally includes surgery and medications such as antibiotics and/or antifungal therapy. Last updated: 2/25/2016

MalaCards based summary : Fournier Gangrene, also known as fournier's gangrene, is related to peritonitis and thrombosis. An important gene associated with Fournier Gangrene is SERPINC1 (Serpin Family C Member 1), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Collagen chain trimerization. The drugs Rho(D) Immune Globulin and gamma-Globulins have been mentioned in the context of this disorder. Affiliated tissues include skin, spinal cord and appendix, and related phenotypes are homeostasis/metabolism and mortality/aging

Wikipedia : 72 Fournier gangrene is a type of necrotizing fasciitis or gangrene affecting the external genitalia and/or... more...

Related Diseases for Fournier Gangrene

Diseases related to Fournier Gangrene via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 215)
# Related Disease Score Top Affiliating Genes
1 peritonitis 29.8 ALB F2
2 thrombosis 29.6 F2 F3 SERPINC1
3 spinal cord infarction 10.3 F2 SERPINC1
4 sudden sensorineural hearing loss 10.3 F2 SERPINC1
5 blood protein disease 10.3 F2 SERPINC1
6 alpha-2-plasmin inhibitor deficiency 10.3 F2 SERPINC1
7 prothrombin deficiency, congenital 10.3 F2 SERPINC1
8 ischemic colitis 10.3 F2 SERPINC1
9 anterior spinal artery syndrome 10.3 F2 SERPINC1
10 subendocardial myocardial infarction 10.3 F2 SERPINC1
11 sneddon syndrome 10.3 F2 SERPINC1
12 retinal vascular occlusion 10.3 F2 SERPINC1
13 antithrombin iii deficiency 10.3 F2 SERPINC1
14 central retinal vein occlusion 10.3 F2 SERPINC1
15 syphilitic meningitis 10.3 CD40LG SERPINC1
16 portal vein thrombosis 10.3 F2 SERPINC1
17 burns 10.3 ALB SERPINC1
18 japanese spotted fever 10.3 CD40LG SERPINC1
19 placental abruption 10.3 F2 SERPINC1
20 ischemic optic neuropathy 10.3 F2 SERPINC1
21 antipyrine metabolism 10.3 ALB F2
22 non-a-e hepatitis 10.3 ALB F2
23 protein c deficiency 10.3 F2 SERPINC1
24 retinal vein occlusion 10.3 F2 SERPINC1
25 livedoid vasculopathy 10.3 CD40LG F2
26 nonarteritic anterior ischemic optic neuropathy 10.2 F2 SERPINC1
27 abdominal tuberculosis 10.2 ALB F2
28 kwashiorkor 10.2 ALB F2
29 hepatic tuberculosis 10.2 ALB F2
30 hepatic coma 10.2 ALB F2
31 legg-calve-perthes disease 10.2 CD40LG SERPINC1
32 osteonecrosis 10.2 F2 SERPINC1
33 hepatitis d 10.2 CD40LG F2
34 ascending cholangitis 10.2 ALB F2
35 pulmonary edema 10.2 F2 SERPINC1
36 intracranial sinus thrombosis 10.2 F3 SERPINC1
37 colorado tick fever 10.2 ALB CD40LG
38 cork-handlers' disease 10.2 ALB CD40LG
39 plasmodium malariae malaria 10.2 ALB CD40LG
40 hepatorenal syndrome 10.2 ALB F2
41 choledocholithiasis 10.2 ALB F2
42 angina pectoris 10.2 F3 SERPINC1
43 yellow nail syndrome 10.2 ALB CD40LG
44 acute liver failure 10.2 ALB F2
45 diffuse glomerulonephritis 10.2 ALB CD40LG
46 cerebral falx meningioma 10.2 F2 F3
47 varicose veins 10.2 F2 SERPINC1
48 factor xii deficiency 10.2 F3 SERPINC1
49 aleutian mink disease 10.2 ALB CD40LG
50 non-secretory myeloma 10.2 ALB CD40LG

Graphical network of the top 20 diseases related to Fournier Gangrene:



Diseases related to Fournier Gangrene

Symptoms & Phenotypes for Fournier Gangrene

MGI Mouse Phenotypes related to Fournier Gangrene:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.43 ALB CD40LG F2 F3 F8 SERPINC1
2 mortality/aging MP:0010768 9.1 ALB CD40LG F2 F3 F8 SERPINC1

Drugs & Therapeutics for Fournier Gangrene

Drugs for Fournier Gangrene (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Rho(D) Immune Globulin Phase 2
2 gamma-Globulins Phase 2
3 Immunoglobulins Phase 2
4 Immunoglobulins, Intravenous Phase 2
5 Antibodies Phase 2
6
Daptomycin Approved, Investigational 103060-53-3 16129629
7
Protein C Approved
8 Anti-Bacterial Agents
9 Anti-Infective Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase III Efficacy and Safety Study of AB103 in the Treatment of Patients With Necrotizing Soft Tissue Infections Recruiting NCT02469857 Phase 3 AB103 0.5 mg/kg
2 Immunoglobulin for Necrotizing Soft Tissue Infections: a Randomised Controlled Trial Completed NCT02111161 Phase 2 IVIG (Privigen);Saline 0.9%
3 Modulation of Biomarkers in Patients With Flesh-eating Bacterial Infections After With Hyperbaric Oxygen Treatment Unknown status NCT02501382
4 Fournier's Gangrene and the Origin of the Infection as a Prognostic of Morbidity and Mortality, an Analysis of 121 Patients Completed NCT03443544
5 Daptomycin for the Treatment of Severe Necrotizing Soft-Tissue Infections Completed NCT00261807 Daptomycin 6mg/kg/day
6 Biomarkers in Patients With Flesh-eating Bacterial Infections Completed NCT02180906
7 Exploratory Study of Raised Serum Lactate as a Marker of Necrotizing Fasciitis Completed NCT01739959
8 Prognosis and Treatment of Necrotizing Soft Tissue Infections: A Prospective Cohort Study Recruiting NCT03147352

Search NIH Clinical Center for Fournier Gangrene

Genetic Tests for Fournier Gangrene

Anatomical Context for Fournier Gangrene

MalaCards organs/tissues related to Fournier Gangrene:

38
Skin, Spinal Cord, Appendix, Testes, Prostate, Colon

Publications for Fournier Gangrene

Articles related to Fournier Gangrene:

(show top 50) (show all 79)
# Title Authors Year
1
Lethal Fournier gangrene following cardiac surgery with cardiopulmonary bypass. ( 27986558 )
2017
2
A fascia lata free flap in pelvic exenteration for Fournier gangrene due to advanced rectal cancer: a case report. ( 28550641 )
2017
3
Bilateral femoral posterior neurocutaneous perforater flap successfully treating Fournier gangrene: A case report. ( 29145312 )
2017
4
Using negative pressure therapy for improving skin graft taking on genital area defects following Fournier gangrene. ( 28861313 )
2017
5
Presentation and Diagnosis of Fournier Gangrene. ( 29146218 )
2017
6
Is hemoglobin A1c level effective in predicting the prognosis of Fournier gangrene? ( 27453658 )
2016
7
Simplified Penoscrotal Reconstruction for Extensive Fournier Gangrene Defects. ( 27928816 )
2016
8
Deep tissue infection of the perineum: Case report and literature review of Fournier gangrene. ( 27255622 )
2016
9
Fournier Gangrene Caused by Candida albicans in an Infant After Cardiac Surgery. ( 27807668 )
2016
10
Evaluation of LRINEC Scale Feasibility for Predicting Outcomes of Fournier Gangrene. ( 27023717 )
2016
11
Fournier Gangrene in Pregnancy. ( 25774932 )
2015
12
Fournier gangrene: rare complication of rectal cancer. ( 26161211 )
2015
13
A Contemporary Analysis of Fournier Gangrene Using the National Surgical Quality Improvement Program. ( 25770725 )
2015
14
Fournier gangrene with extensive necrosis of urethra and bladder mucosa: A rare occurrence in a patient with advanced prostate cancer. ( 26692675 )
2015
15
Comparison of Diverting Colostomy and Bowel Management Catheter Applications in Fournier Gangrene Cases Requiring Fecal Diversion. ( 26730041 )
2015
16
Unusual foreign body in the sigmoid colon, chronic alcohol abuse, and Fournier gangrene: a case report. ( 25878494 )
2015
17
Fournier gangrene. ( 25838914 )
2015
18
Negative pressure wound therapy applied before and after split-thickness skin graft helps healing of Fournier gangrene: a case report (CARE-Compliant). ( 25654376 )
2015
19
Reconstruction of Defects After Fournier Gangrene: A Systematic Review. ( 26171090 )
2015
20
Xenogenic (porcine) acellular dermal matrix promotes growth of granulation tissues in the wound healing of Fournier gangrene. ( 25569072 )
2015
21
Temporary Relocation of the Testes in Anteromedial Thigh Pouches Facilitates Delayed Primary Scrotal Wound Closure in Fournier Gangrene With Extensive Loss of Scrotal Skin-Experience With 12 Cases. ( 25785387 )
2015
22
Bilateral adrenal haemorrhage associated with heparin-induced thrombocytopaenia during treatment of Fournier gangrene. ( 25315802 )
2014
23
FDG PET/CT Images Demonstrating Fournier Gangrene With Bilateral Pelvic Muscle Extension in a Patient With Recurrent Rectosigmoid Cancer. ( 23510891 )
2014
24
Emergence of Antibiotic-Resistant Bacteria in Patients with Fournier Gangrene. ( 25215467 )
2014
25
Bilateral Necrotizing Fasciitis around the Hips Differentiated from Fournier Gangrene: A Case Report. ( 27536594 )
2014
26
Solitary Candida albicans Infection Causing Fournier Gangrene and Review of Fungal Etiologies. ( 25009452 )
2014
27
Favorable outcome of Fournier gangrene in two patients with diabetes mellitus on continuous peritoneal dialysis. ( 25338433 )
2014
28
Enterostomy can decrease the mortality of patients with Fournier gangrene. ( 24976731 )
2014
29
Emergency radiology eponyms: part 2--Naclerio's V sign to Fournier gangrene. ( 23065070 )
2013
30
Fournier gangrene as a manifestation of undiagnosed metastatic perforated colorectal cancer. ( 23438275 )
2013
31
2-octyl-cyanoacrylate glue for fixation of STSG in genitourinary tissue defects due to Fournier gangrene: a preliminary trial. ( 23720107 )
2013
32
Abdominal implantation of testicles in the management of intractable testicular pain in fournier gangrene. ( 24229025 )
2013
33
Fournier gangrene from a thirty-two-centimeter rectosigmoid foreign body. ( 23200766 )
2013
34
Fournier gangrene: an unusual presentation involving the bulbous urethra and forming free gas in the urinary bladder. ( 21820264 )
2013
35
Fournier gangrene and unexpected death. ( 22471925 )
2012
36
A clinical case of Fournier gangrene. ( 23025122 )
2012
37
Fournier gangrene: description of 37 cases and analysis of associated health care costs. ( 22445562 )
2012
38
Prognostic factors in Fournier gangrene. ( 22726562 )
2012
39
Fournier gangrene: our approach and patients. ( 21849758 )
2011
40
The emergency computed tomography as important modality for early diagnosis of Fournier gangrene. ( 20951534 )
2011
41
Neonatal scrotal wall necrotizing fasciitis (Fournier gangrene): a case report. ( 22151925 )
2011
42
Is intensive multimodality therapy the best treatment for fournier gangrene? Evaluation of clinical outcome and survival rate of 41 patients. ( 21943303 )
2011
43
Fournier gangrene: first manifestation of occult rectal cancer. ( 22191139 )
2011
44
Fournier gangrene. ( 20411094 )
2010
45
F-18 fluorodeoxyglucose PET in Fournier gangrene. ( 20631519 )
2010
46
Medial thigh fasciocutaneous flaps for reconstruction of the scrotum following Fournier gangrene. ( 20048591 )
2010
47
Fournier gangrene: rapid diagnosis with bedside ultrasonography. ( 21073782 )
2010
48
Extended retroperitoneal necrotizing fasciitis with genital involvement, resembling fournier gangrene. ( 20583955 )
2010
49
Fournier gangrene: a review of 41 patients and strategies for reconstruction. ( 20407363 )
2010
50
Pleomorphic malignant fibrous histiocytoma/undifferentiated high-grade pleomorphic sarcoma of the scrotum in a patient presenting as fournier gangrene: a case report. ( 20505510 )
2010

Variations for Fournier Gangrene

Expression for Fournier Gangrene

Search GEO for disease gene expression data for Fournier Gangrene.

GO Terms for Fournier Gangrene

Cellular components related to Fournier Gangrene according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.63 ALB CD40LG F2 F3 F8 SERPINC1
2 blood microparticle GO:0072562 9.43 ALB F2 SERPINC1
3 platelet alpha granule lumen GO:0031093 9.32 ALB F8
4 endoplasmic reticulum lumen GO:0005788 9.26 ALB F2 F8 SERPINC1
5 extracellular space GO:0005615 9.1 ALB CD40LG F2 F3 F8 SERPINC1

Biological processes related to Fournier Gangrene according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.54 ALB F2 SERPINC1
2 acute-phase response GO:0006953 9.4 F2 F8
3 platelet activation GO:0030168 9.33 CD40LG F2 F8
4 regulation of blood coagulation GO:0030193 9.32 F2 SERPINC1
5 blood coagulation, intrinsic pathway GO:0007597 9.26 F2 F8
6 blood coagulation GO:0007596 9.26 F2 F3 F8 SERPINC1
7 hemostasis GO:0007599 8.92 F2 F3 F8 SERPINC1

Molecular functions related to Fournier Gangrene according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 copper ion binding GO:0005507 8.62 ALB F8

Sources for Fournier Gangrene

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....