MCID: FRN014
MIFTS: 34

Fournier Gangrene malady

Category: Rare diseases

Aliases & Classifications for Fournier Gangrene

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Aliases & Descriptions for Fournier Gangrene:

Name: Fournier Gangrene 47 67
 
Fournier's Gangrene 47

Classifications:



Summaries for Fournier Gangrene

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Wikipedia:70 Fournier gangrene is a type of necrotizing fasciitis or gangrene affecting the perineum. It commonly... more...

MalaCards based summary: Fournier Gangrene, also known as fournier's gangrene, is related to adenocarcinoma and fibrous histiocytoma. An important gene associated with Fournier Gangrene is SERPINC1 (Serpin Family C Member 1), and among its related pathways are FOXA2 and FOXA3 transcription factor networks and Collagen biosynthesis and modifying enzymes. Affiliated tissues include spinal cord, skin and appendix, and related mouse phenotypes are hematopoietic system and homeostasis/metabolism.

Related Diseases for Fournier Gangrene

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Diseases related to Fournier Gangrene via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 207)
idRelated DiseaseScoreTop Affiliating Genes
1adenocarcinoma29.9ALB, CD40LG
2fibrous histiocytoma29.5ALB, CD40LG, F2
3subcortical arteriosclerotic encephalopathy10.4F2, SERPINC1
4thyroid hyalinizing trabecular adenoma10.4F2, SERPINC1
5milk allergy10.4F2, SERPINC1
6collagenous colitis10.4F2, SERPINC1
7hypertensive heart disease10.4F2, SERPINC1
8spleen cancer10.4F2, SERPINC1
9thrombophilia due to thrombin defect10.4F2, SERPINC1
10posterolateral myocardial infarction10.4F2, SERPINC1
11may-hegglin anomaly10.4F2, SERPINC1
12left-right axis malformations10.4F2, SERPINC1
13histoplasmosis10.4F2, SERPINC1
14budd-chiari syndrome10.4F2, SERPINC1
15functional colonic disease10.4F2, SERPINC1
16thrombophilia10.4F2, SERPINC1
17diphyllobothriasis10.4CD40LG, SERPINC1
18selective iga deficiency disease10.4F2, SERPINC1
19cartilage disease10.4ALB, SERPINC1
20rocky mountain spotted fever10.4CD40LG, SERPINC1
21joint disorders10.3F2, SERPINC1
22hereditary antithrombin deficiency type i10.3ALB, F2
23sacrococcygeal teratoma10.3F2, SERPINC1
24unicentric castleman disease10.3CD40LG, F2
25oral cavity carcinoma in situ10.3ALB, F2
26stickler sydrome, type i, nonsyndromic ocular10.3CD40LG, SERPINC1
27exophthalmic ophthalmoplegia10.3F2, SERPINC1
28alpha-2-plasmin inhibitor deficiency10.3F2, SERPINC1
29duodenal disease10.3ALB, F2
30acute kidney tubular necrosis10.3ALB, F2
31parathyroid gland disease10.3ALB, F2
32alveolar periostitis10.3ALB, F2
33acute maxillary sinusitis10.3CD40LG, F2
34degenerative myopia10.3ALB, F2
35pancreatic solid pseudopapillary carcinoma10.3ALB, F2
36cavernous sinus thrombosis10.3F3, SERPINC1
37bronchial disease10.3ALB, F2
38pericholangitis10.3ALB, F2
39postencephalitic parkinson disease10.3ALB, CD40LG
40pyeloureteritis cystica10.3ALB, F2
41testicular brenner tumor10.3ALB, CD40LG
42acute liver failure10.3ALB, F2
43ovarian insufficiency, familial10.3F2, SERPINC1
44adie pupil10.3ALB, CD40LG
45spondylosis10.3CD40LG, F2
46chronic diarrhea due to guanylate cyclase 2c overactivity10.3F3, SERPINC1
47capillary hemangioma10.3ALB, CD40LG
48familial glomangioma10.2F2, F3
49mesangial proliferative glomerulonephritis10.2ALB, CD40LG
50cerebral angioma10.2F2, F3

Graphical network of the top 20 diseases related to Fournier Gangrene:



Diseases related to fournier gangrene

Symptoms for Fournier Gangrene

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Drugs & Therapeutics for Fournier Gangrene

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Drugs for Fournier Gangrene (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1AntibodiesPhase 26045
2Rho(D) Immune GlobulinPhase 2317
3ImmunoglobulinsPhase 26045
4Immunoglobulins, IntravenousPhase 2324
5Immunoglobulin GPhase 2265
6gamma-GlobulinsPhase 2317
7
Daptomycinapproved, investigational86103060-53-316129629
Synonyms:
103060-53-3
AKOS005146218
C12013
C72H101N17O26
CHEBI:600103
CHEMBL508162
Cidecin
Cubicin
Cubicin (TN)
D01080
DAPTOMYCIN
Dapcin
Daptomicina
Daptomicina [Spanish]
Daptomycin (JAN/USAN/INN)
Daptomycin [USAN:INN:BAN]
Daptomycine
 
Daptomycine [French]
Daptomycinum
Daptomycinum [Latin]
Deptomycin
LS-171846
LY 146032
LY-146032
LY146032
MK-3009
MolPort-003-846-138
N-Decanoyl-L-tryptophyl-L-asparaginyl-L-aspartyl-L-threonylglycyl-L-ornithyl-L-aspartyl-D-alanyl-L-aspartylglycyl-D-seryl-threo-3-methyl-L-glutamyl-3-anthraniloyl-L-alanine epsilon1-lactone
N-decanoyl-L-tryptophyl-D-asparaginyl-L-aspartyl-L-threonylglycyl-L-ornithyl-L-aspartyl-D-alanyl-L-aspartylglycyl-D-seryl-threo-3-methyl-L-glutamyl-3-anthraniloyl-L-alanine 1.13-3.4-lactone
N-decanoyl-L-tryptophyl-D-asparaginyl-L-aspartyl-L-threonylglycyl-L-ornithyl-L-aspartyl-D-alanyl-L-aspartylglycyl-D-seryl-threo-3-methyl-L-glutamyl-3-anthraniloyl-L-alanine epsilon(1)-lactone
N-decanoyl-L-tryptophyl-D-asparaginyl-N-[(3S,6S,9R,15S,18R,21S,24S,30S,31R)-3-[2-(2-aminophenyl)-2-oxoethyl]-24-(3-aminopropyl)-15,21-bis(carboxymethyl)-6-[(2R)-1-carboxypropan-2-yl]-9-(hydroxymethyl)-18,31-dimethyl-2,5,8,11,14,17,20,23,26,29-decaoxo-1-oxa-4,7,10,13,16,19,22,25,28-nonaazacyclohentriacontan-30-yl]-L-alpha-asparagine
N-decanoyl-L-tryptophyl-L-asparaginyl-N-[(3S,6S,9R,15S,18R,21S,24S,30S,31R)-3-[2-(2-aminophenyl)-2-oxoethyl]-24-(3-aminopropyl)-15,21-bis(carboxymethyl)-6-[(2R)-1-carboxypropan-2-yl]-9-(hydroxymethyl)-18,31-dimethyl-2,5,8,11,14,17,20,23,26,29-decaoxo-1-ox
N-decanoyl-L-tryptophyl-L-asparaginyl-N-[(3S,6S,9R,15S,18R,21S,24S,30S,31R)-3-[2-(2-aminophenyl)-2-oxoethyl]-24-(3-aminopropyl)-15,21-bis(carboxymethyl)-6-[(2R)-1-carboxypropan-2-yl]-9-(hydroxymethyl)-18,31-dimethyl-2,5,8,11,14,17,20,23,26,29-decaoxo-1-oxa-4,7,10,13,16,19,22,25,28-nonaazacyclohentriacontan-30-yl]-L-alpha-asparagine
UNII-NWQ5N31VKK
daptomycin
nchembio.184-comp5
8Anti-Bacterial Agents10884
9Anti-Infective Agents21402

Interventional clinical trials:

idNameStatusNCT IDPhase
1Phase III Efficacy and Safety Study of AB103 in the Treatment of Patients With Necrotizing Soft Tissue InfectionsRecruitingNCT02469857Phase 3
2Immunoglobulin for Necrotizing Soft Tissue Infections: a Randomised Controlled TrialCompletedNCT02111161Phase 2
3Daptomycin for the Treatment of Severe Necrotizing Soft-Tissue InfectionsCompletedNCT00261807
4Biomarkers in Patients With Flesh-eating Bacterial InfectionsCompletedNCT02180906
5Exploratory Study of Raised Serum Lactate as a Marker of Necrotizing FasciitisCompletedNCT01739959
6Modulation of Biomarkers in Patients With Flesh-eating Bacterial Infections After With Hyperbaric Oxygen TreatmentRecruitingNCT02501382

Search NIH Clinical Center for Fournier Gangrene

Genetic Tests for Fournier Gangrene

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Anatomical Context for Fournier Gangrene

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MalaCards organs/tissues related to Fournier Gangrene:

35
Spinal cord, Skin, Appendix, Testes, Prostate, Colon

Animal Models for Fournier Gangrene or affiliated genes

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MGI Mouse Phenotypes related to Fournier Gangrene:

40
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053978.5CD40LG, F2, F3, F8, SERPINC1
2MP:00053767.9ALB, CD40LG, F2, F3, F8, SERPINC1
3MP:00107687.1ALB, CD40LG, F2, F3, F8, SERPINC1

Publications for Fournier Gangrene

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Articles related to Fournier Gangrene:

(show top 50)    (show all 75)
idTitleAuthorsYear
1
Evaluation of LRINEC Scale Feasibility for Predicting Outcomes of Fournier Gangrene. (27023717)
2016
2
Deep tissue infection of the perineum: Case report and literature review of Fournier gangrene. (27255622)
2016
3
Fournier Gangrene Caused by Candida albicans in an Infant After Cardiac Surgery. (27807668)
2016
4
Fournier Gangrene in Pregnancy. (25774932)
2015
5
Temporary Relocation of the Testes in Anteromedial Thigh Pouches Facilitates Delayed Primary Scrotal Wound Closure in Fournier Gangrene With Extensive Loss of Scrotal Skin-Experience With 12 Cases. (25785387)
2015
6
Unusual foreign body in the sigmoid colon, chronic alcohol abuse, and Fournier gangrene: a case report. (25878494)
2015
7
Negative pressure wound therapy applied before and after split-thickness skin graft helps healing of Fournier gangrene: a case report (CARE-Compliant). (25654376)
2015
8
Comparison of Diverting Colostomy and Bowel Management Catheter Applications in Fournier Gangrene Cases Requiring Fecal Diversion. (26730041)
2015
9
Fournier gangrene: rare complication of rectal cancer. (26161211)
2015
10
Reconstruction of Defects After Fournier Gangrene: A Systematic Review. (26171090)
2015
11
Xenogenic (porcine) acellular dermal matrix promotes growth of granulation tissues in the wound healing of Fournier gangrene. (25569072)
2015
12
Bilateral Necrotizing Fasciitis around the Hips Differentiated from Fournier Gangrene: A Case Report. (27536594)
2014
13
FDG PET/CT Images Demonstrating Fournier Gangrene With Bilateral Pelvic Muscle Extension in a Patient With Recurrent Rectosigmoid Cancer. (23510891)
2014
14
Enterostomy can decrease the mortality of patients with Fournier gangrene. (24976731)
2014
15
Solitary Candida albicans Infection Causing Fournier Gangrene and Review of Fungal Etiologies. (25009452)
2014
16
Abdominal implantation of testicles in the management of intractable testicular pain in fournier gangrene. (24229025)
2013
17
Fournier gangrene as a manifestation of undiagnosed metastatic perforated colorectal cancer. (23438275)
2013
18
Emergency radiology eponyms: part 2--Naclerio's V sign to Fournier gangrene. (23065070)
2013
19
2-octyl-cyanoacrylate glue for fixation of STSG in genitourinary tissue defects due to Fournier gangrene: a preliminary trial. (23720107)
2013
20
Prognostic factors in Fournier gangrene. (22726562)
2012
21
Fournier gangrene and unexpected death. (22471925)
2012
22
Is intensive multimodality therapy the best treatment for fournier gangrene? Evaluation of clinical outcome and survival rate of 41 patients. (21943303)
2011
23
Fournier gangrene: our approach and patients. (21849758)
2011
24
Neonatal scrotal wall necrotizing fasciitis (Fournier gangrene): a case report. (22151925)
2011
25
The emergency computed tomography as important modality for early diagnosis of Fournier gangrene. (20951534)
2011
26
Extended retroperitoneal necrotizing fasciitis with genital involvement, resembling fournier gangrene. (20583955)
2010
27
F-18 fluorodeoxyglucose PET in Fournier gangrene. (20631519)
2010
28
Pleomorphic malignant fibrous histiocytoma/undifferentiated high-grade pleomorphic sarcoma of the scrotum in a patient presenting as fournier gangrene: a case report. (20505510)
2010
29
Fournier gangrene. (20411094)
2010
30
Fournier gangrene: rapid diagnosis with bedside ultrasonography. (21073782)
2010
31
Fournier gangrene. (19959869)
2009
32
The beneficial role of patient-controlled epidural analgesia in a patient with fournier gangrene. (19282721)
2009
33
Fournier gangrene: role of imaging. (18349455)
2008
34
A 12-month-old infant with Fournier gangrene associated with varicella. (18090105)
2007
35
Fournier gangrene. (17034687)
2006
36
Scrotal reconstruction following fournier gangrene using the medial circumflex femoral artery perforator flap. (16929205)
2006
37
Fournier gangrene. Approaches to diagnosis and treatment. (16830027)
2006
38
Fournier gangrene: a series of 12 patients. (17559034)
2006
39
Anal tumor diagnosed after the recovery of Fournier gangrene. (16642420)
2006
40
Group C streptococcal sepsis complicating Fournier gangrene. (16217985)
2005
41
Fournier gangrene in spinal cord injury: a case report. (15889700)
2005
42
Case 54: Fournier gangrene. (12511678)
2003
43
Inner thigh lift flap" for Fournier gangrene of the scrotum. (12360093)
2002
44
Fournier gangrene associated with Crohn disease. (10852429)
2000
45
Picture of the month. Fournier gangrene. (8954006)
1996
46
US case of the day. Fournier gangrene. (7855351)
1994
47
Fournier gangrene caused by a perforated retroperitoneal appendix: CT demonstration. (1898809)
1991
48
Fournier gangrene following urethral necrosis by indwelling catheter. (6695486)
1984
49
Radiological features of Fournier gangrene. (7280228)
1981
50
Urology-epitomes of progress: recent experience in the management of fournier gangrene. (18748404)
1979

Variations for Fournier Gangrene

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Expression for genes affiliated with Fournier Gangrene

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Search GEO for disease gene expression data for Fournier Gangrene.

Pathways for genes affiliated with Fournier Gangrene

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GO Terms for genes affiliated with Fournier Gangrene

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Cellular components related to Fournier Gangrene according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:00310939.7ALB, F8
2blood microparticleGO:00725629.1ALB, F2, SERPINC1
3extracellular spaceGO:00056156.8ALB, CD40LG, F2, F3, F8, SERPINC1

Biological processes related to Fournier Gangrene according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1blood coagulation, intrinsic pathwayGO:00075979.6F2, F8
2acute-phase responseGO:00069539.5F2, F8
3platelet activationGO:00301688.8CD40LG, F2, F8
4blood coagulationGO:00075968.2F2, F3, F8, SERPINC1

Molecular functions related to Fournier Gangrene according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1copper ion bindingGO:00055079.0ALB, F8
2serine-type endopeptidase activityGO:00042528.6F2, F3, F8

Sources for Fournier Gangrene

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
26GTR
27HGMD
28HMDB
29ICD10
30ICD10 via Orphanet
31ICD9CM
32IUPHAR
33KEGG
36MedGen
38MeSH
39MESH via Orphanet
40MGI
43NCI
44NCIt
45NDF-RT
48NINDS
49Novoseek
51OMIM
52OMIM via Orphanet
56PubMed
57QIAGEN
62SNOMED-CT via Orphanet
66Tumor Gene Family of Databases
67UMLS
68UMLS via Orphanet