MCID: FRN014
MIFTS: 35

Fournier Gangrene malady

Category: Rare diseases

Aliases & Classifications for Fournier Gangrene

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Aliases & Descriptions for Fournier Gangrene:

Name: Fournier Gangrene 48 68
 
Fournier's Gangrene 48

Classifications:



Summaries for Fournier Gangrene

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NIH Rare Diseases:48 Fournier gangrene refers to the death of body tissue of the genitals and/or perineum. signs and symptoms of the condition include genital pain, tenderness, redness, and swelling with a rapid progression to gangrene. although the condition can affect men and women of all ages, it is most commonly diagnosed in adult males. most cases of fournier gangrene are caused by an infection in the genital area or urinary tract. people with impaired immunity (i.e. due to diabetes or hiv) have an increased susceptibility to the condition. treatment generally includes surgery and medications such as antibiotics and/or antifungal therapy. last updated: 2/25/2016

MalaCards based summary: Fournier Gangrene, also known as fournier's gangrene, is related to vascular erectile tumor and miller-dieker lissencephaly syndrome. An important gene associated with Fournier Gangrene is SERPINC1 (Serpin Family C Member 1), and among its related pathways are FOXA2 and FOXA3 transcription factor networks and Collagen chain trimerization. Affiliated tissues include spinal cord, skin and appendix, and related mouse phenotypes are homeostasis/metabolism and mortality/aging.

Wikipedia:71 Fournier gangrene is a type of necrotizing fasciitis or gangrene affecting the perineum. It commonly... more...

Related Diseases for Fournier Gangrene

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Diseases related to Fournier Gangrene via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 200)
idRelated DiseaseScoreTop Affiliating Genes
1vascular erectile tumor10.2F2, SERPINC1
2miller-dieker lissencephaly syndrome10.2F2, SERPINC1
3mixed epithelial tumor of ovary10.2F2, SERPINC1
4peanut allergy10.2F2, SERPINC1
5may-hegglin anomaly10.2F2, SERPINC1
6left-right axis malformations10.2F2, SERPINC1
7lymphocytic colitis10.2F2, SERPINC1
8schwannoma of jugular foramen10.2F2, SERPINC1
9cerebellar astrocytoma10.2F2, SERPINC1
10periosteal chondrosarcoma10.2F2, SERPINC1
11cryptosporidiosis10.2F2, SERPINC1
12cysticercosis10.2CD40LG, SERPINC1
13angular blepharoconjunctivitis10.2F2, SERPINC1
14cataract10.2ALB, SERPINC1
15dysgammaglobulinemia10.2F2, SERPINC1
16nondystrophic myotonia10.2ALB, F2
17oropharyngeal anthrax10.2CD40LG, SERPINC1
18ophthalmia neonatorum10.2F2, SERPINC1
19lubinsky syndrome10.2CD40LG, F2
20vaginal discharge10.2F2, SERPINC1
21pharynx carcinoma in situ10.2ALB, F2
22alpha-2-plasmin inhibitor deficiency10.2F2, SERPINC1
23female infertility of uterine origin10.2ALB, F2
24czech dysplasia10.2CD40LG, SERPINC1
25bile duct cystadenocarcinoma10.2ALB, F2
26duane retraction syndrome10.2ALB, F2
27maxillary sinusitis10.2CD40LG, F2
28malignant hyperthermia susceptibility 110.2ALB, SERPINC1
29scar contracture10.2F2, SERPINC1
30bile duct adenocarcinoma10.2ALB, CD40LG
31sertoli cell tumor10.2F3, SERPINC1
32colloid adenoma10.2ALB, CD40LG
33kohler's disease10.2ALB, F2
34estrogen excess10.2ALB, CD40LG
35myopia10.2ALB, F2
36striatonigral degeneration10.2ALB, CD40LG
37inner ear disease10.2ALB, CD40LG
38dyskeratosis congenita10.1ALB, CD40LG
39atrophic vulva10.1ALB, F2
40neuronopathy, distal hereditary motor, type iid10.1F3, SERPINC1
41coronary artery dissection, spontaneous10.1ALB, CD40LG
42secretory diarrhea myopathy and deafness10.1F3, SERPINC1
43hemarthrosis10.1F2, F3
44acute monocytic leukemia10.1ALB, F2
45conjunctivochalasis10.1F3, SERPINC1
46hendra virus infection10.1F2, F3
47prostatic hypertrophy10.1F2, F3
48angiokeratoma10.1ALB, CD40LG
49monocular exotropia10.1F3, SERPINC1
50vulvar sarcoma10.1ALB, CD40LG

Graphical network of the top 20 diseases related to Fournier Gangrene:



Diseases related to fournier gangrene

Symptoms & Phenotypes for Fournier Gangrene

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MGI Mouse Phenotypes related to Fournier Gangrene according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053767.9ALB, CD40LG, F2, F3, F8, SERPINC1
2MP:00107687.1ALB, CD40LG, F2, F3, F8, SERPINC1

Drugs & Therapeutics for Fournier Gangrene

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Drugs for Fournier Gangrene (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1AntibodiesPhase 26394
2Rho(D) Immune GlobulinPhase 2326
3ImmunoglobulinsPhase 26394
4Immunoglobulins, IntravenousPhase 2333
5Immunoglobulin GPhase 2275
6gamma-GlobulinsPhase 2326
7
Daptomycinapproved, investigational88103060-53-316129629
Synonyms:
103060-53-3
AKOS005146218
C12013
C72H101N17O26
CHEBI:600103
CHEMBL508162
Cidecin
Cubicin
Cubicin (TN)
D01080
DAPTOMYCIN
Dapcin
Daptomicina
Daptomicina [Spanish]
Daptomycin (JAN/USAN/INN)
Daptomycin [USAN:INN:BAN]
Daptomycine
 
Daptomycine [French]
Daptomycinum
Daptomycinum [Latin]
Deptomycin
LS-171846
LY 146032
LY-146032
LY146032
MK-3009
MolPort-003-846-138
N-Decanoyl-L-tryptophyl-L-asparaginyl-L-aspartyl-L-threonylglycyl-L-ornithyl-L-aspartyl-D-alanyl-L-aspartylglycyl-D-seryl-threo-3-methyl-L-glutamyl-3-anthraniloyl-L-alanine epsilon1-lactone
N-decanoyl-L-tryptophyl-D-asparaginyl-L-aspartyl-L-threonylglycyl-L-ornithyl-L-aspartyl-D-alanyl-L-aspartylglycyl-D-seryl-threo-3-methyl-L-glutamyl-3-anthraniloyl-L-alanine 1.13-3.4-lactone
N-decanoyl-L-tryptophyl-D-asparaginyl-L-aspartyl-L-threonylglycyl-L-ornithyl-L-aspartyl-D-alanyl-L-aspartylglycyl-D-seryl-threo-3-methyl-L-glutamyl-3-anthraniloyl-L-alanine epsilon(1)-lactone
N-decanoyl-L-tryptophyl-D-asparaginyl-N-[(3S,6S,9R,15S,18R,21S,24S,30S,31R)-3-[2-(2-aminophenyl)-2-oxoethyl]-24-(3-aminopropyl)-15,21-bis(carboxymethyl)-6-[(2R)-1-carboxypropan-2-yl]-9-(hydroxymethyl)-18,31-dimethyl-2,5,8,11,14,17,20,23,26,29-decaoxo-1-oxa-4,7,10,13,16,19,22,25,28-nonaazacyclohentriacontan-30-yl]-L-alpha-asparagine
N-decanoyl-L-tryptophyl-L-asparaginyl-N-[(3S,6S,9R,15S,18R,21S,24S,30S,31R)-3-[2-(2-aminophenyl)-2-oxoethyl]-24-(3-aminopropyl)-15,21-bis(carboxymethyl)-6-[(2R)-1-carboxypropan-2-yl]-9-(hydroxymethyl)-18,31-dimethyl-2,5,8,11,14,17,20,23,26,29-decaoxo-1-ox
N-decanoyl-L-tryptophyl-L-asparaginyl-N-[(3S,6S,9R,15S,18R,21S,24S,30S,31R)-3-[2-(2-aminophenyl)-2-oxoethyl]-24-(3-aminopropyl)-15,21-bis(carboxymethyl)-6-[(2R)-1-carboxypropan-2-yl]-9-(hydroxymethyl)-18,31-dimethyl-2,5,8,11,14,17,20,23,26,29-decaoxo-1-oxa-4,7,10,13,16,19,22,25,28-nonaazacyclohentriacontan-30-yl]-L-alpha-asparagine
UNII-NWQ5N31VKK
daptomycin
nchembio.184-comp5
8Anti-Bacterial Agents11226
9Anti-Infective Agents22062
10Protein C118

Interventional clinical trials:

idNameStatusNCT IDPhase
1Phase III Efficacy and Safety Study of AB103 in the Treatment of Patients With Necrotizing Soft Tissue InfectionsRecruitingNCT02469857Phase 3
2Immunoglobulin for Necrotizing Soft Tissue Infections: a Randomised Controlled TrialCompletedNCT02111161Phase 2
3Daptomycin for the Treatment of Severe Necrotizing Soft-Tissue InfectionsCompletedNCT00261807
4Biomarkers in Patients With Flesh-eating Bacterial InfectionsCompletedNCT02180906
5Exploratory Study of Raised Serum Lactate as a Marker of Necrotizing FasciitisCompletedNCT01739959
6Modulation of Biomarkers in Patients With Flesh-eating Bacterial Infections After With Hyperbaric Oxygen TreatmentRecruitingNCT02501382
7Prognosis and Treatment of Necrotizing Soft Tissue Infections: A Prospective Cohort StudyRecruitingNCT03147352

Search NIH Clinical Center for Fournier Gangrene

Genetic Tests for Fournier Gangrene

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Anatomical Context for Fournier Gangrene

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MalaCards organs/tissues related to Fournier Gangrene:

36
Spinal cord, Skin, Appendix, Testes, Prostate, Colon

Publications for Fournier Gangrene

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Articles related to Fournier Gangrene:

(show top 50)    (show all 75)
idTitleAuthorsYear
1
Lethal Fournier gangrene following cardiac surgery with cardiopulmonary bypass. (27986558)
2017
2
Fournier Gangrene Caused by Candida albicans in an Infant After Cardiac Surgery. (27807668)
2016
3
Simplified Penoscrotal Reconstruction for Extensive Fournier Gangrene Defects. (27928816)
2016
4
Evaluation of LRINEC Scale Feasibility for Predicting Outcomes of Fournier Gangrene. (27023717)
2016
5
Deep tissue infection of the perineum: Case report and literature review of Fournier gangrene. (27255622)
2016
6
Is hemoglobin A1c level effective in predicting the prognosis of Fournier gangrene? (27453658)
2016
7
Fournier gangrene with extensive necrosis of urethra and bladder mucosa: A rare occurrence in a patient with advanced prostate cancer. (26692675)
2015
8
Negative pressure wound therapy applied before and after split-thickness skin graft helps healing of Fournier gangrene: a case report (CARE-Compliant). (25654376)
2015
9
A Contemporary Analysis of Fournier Gangrene Using the National Surgical Quality Improvement Program. (25770725)
2015
10
Xenogenic (porcine) acellular dermal matrix promotes growth of granulation tissues in the wound healing of Fournier gangrene. (25569072)
2015
11
Unusual foreign body in the sigmoid colon, chronic alcohol abuse, and Fournier gangrene: a case report. (25878494)
2015
12
Fournier gangrene: rare complication of rectal cancer. (26161211)
2015
13
Reconstruction of Defects After Fournier Gangrene: A Systematic Review. (26171090)
2015
14
Fournier gangrene. (25838914)
2015
15
Temporary Relocation of the Testes in Anteromedial Thigh Pouches Facilitates Delayed Primary Scrotal Wound Closure in Fournier Gangrene With Extensive Loss of Scrotal Skin-Experience With 12 Cases. (25785387)
2015
16
Fournier Gangrene in Pregnancy. (25774932)
2015
17
Comparison of Diverting Colostomy and Bowel Management Catheter Applications in Fournier Gangrene Cases Requiring Fecal Diversion. (26730041)
2015
18
Emergence of Antibiotic-Resistant Bacteria in Patients with Fournier Gangrene. (25215467)
2014
19
Favorable outcome of Fournier gangrene in two patients with diabetes mellitus on continuous peritoneal dialysis. (25338433)
2014
20
FDG PET/CT Images Demonstrating Fournier Gangrene With Bilateral Pelvic Muscle Extension in a Patient With Recurrent Rectosigmoid Cancer. (23510891)
2014
21
Bilateral Necrotizing Fasciitis around the Hips Differentiated from Fournier Gangrene: A Case Report. (27536594)
2014
22
Solitary Candida albicans Infection Causing Fournier Gangrene and Review of Fungal Etiologies. (25009452)
2014
23
Enterostomy can decrease the mortality of patients with Fournier gangrene. (24976731)
2014
24
Bilateral adrenal haemorrhage associated with heparin-induced thrombocytopaenia during treatment of Fournier gangrene. (25315802)
2014
25
Emergency radiology eponyms: part 2--Naclerio's V sign to Fournier gangrene. (23065070)
2013
26
Fournier gangrene as a manifestation of undiagnosed metastatic perforated colorectal cancer. (23438275)
2013
27
Fournier gangrene: an unusual presentation involving the bulbous urethra and forming free gas in the urinary bladder. (21820264)
2013
28
Fournier gangrene from a thirty-two-centimeter rectosigmoid foreign body. (23200766)
2013
29
2-octyl-cyanoacrylate glue for fixation of STSG in genitourinary tissue defects due to Fournier gangrene: a preliminary trial. (23720107)
2013
30
Abdominal implantation of testicles in the management of intractable testicular pain in fournier gangrene. (24229025)
2013
31
A clinical case of Fournier gangrene. (23025122)
2012
32
Prognostic factors in Fournier gangrene. (22726562)
2012
33
Fournier gangrene: description of 37 cases and analysis of associated health care costs. (22445562)
2012
34
Fournier gangrene and unexpected death. (22471925)
2012
35
The emergency computed tomography as important modality for early diagnosis of Fournier gangrene. (20951534)
2011
36
Fournier gangrene: first manifestation of occult rectal cancer. (22191139)
2011
37
Fournier gangrene: our approach and patients. (21849758)
2011
38
Neonatal scrotal wall necrotizing fasciitis (Fournier gangrene): a case report. (22151925)
2011
39
Is intensive multimodality therapy the best treatment for fournier gangrene? Evaluation of clinical outcome and survival rate of 41 patients. (21943303)
2011
40
Medial thigh fasciocutaneous flaps for reconstruction of the scrotum following Fournier gangrene. (20048591)
2010
41
Fournier gangrene: rapid diagnosis with bedside ultrasonography. (21073782)
2010
42
Fournier gangrene: a review of 41 patients and strategies for reconstruction. (20407363)
2010
43
F-18 fluorodeoxyglucose PET in Fournier gangrene. (20631519)
2010
44
Pleomorphic malignant fibrous histiocytoma/undifferentiated high-grade pleomorphic sarcoma of the scrotum in a patient presenting as fournier gangrene: a case report. (20505510)
2010
45
Extended retroperitoneal necrotizing fasciitis with genital involvement, resembling fournier gangrene. (20583955)
2010
46
Fournier gangrene. (20411094)
2010
47
Fournier gangrene presenting in a patient with undiagnosed rectal adenocarcinoma: a case report. (20062653)
2009
48
A short history of Fournier gangrene. (19221264)
2009
49
The beneficial role of patient-controlled epidural analgesia in a patient with fournier gangrene. (19282721)
2009
50
Fournier gangrene. (19959869)
2009

Variations for Fournier Gangrene

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Expression for genes affiliated with Fournier Gangrene

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Search GEO for disease gene expression data for Fournier Gangrene.

Pathways for genes affiliated with Fournier Gangrene

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GO Terms for genes affiliated with Fournier Gangrene

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Cellular components related to Fournier Gangrene according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1blood microparticleGO:00725629.9ALB, F2, SERPINC1
2platelet alpha granule lumenGO:00310939.1ALB, F8
3endoplasmic reticulum lumenGO:00057889.0ALB, F2, F8, SERPINC1
4extracellular regionGO:00055767.8ALB, CD40LG, F2, F3, F8, SERPINC1
5extracellular spaceGO:00056157.6ALB, CD40LG, F2, F3, F8, SERPINC1

Biological processes related to Fournier Gangrene according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1acute-phase responseGO:00069539.9F2, F8
2blood coagulation, intrinsic pathwayGO:00075979.8F2, F8
3cellular protein metabolic processGO:00442679.7ALB, F2, SERPINC1
4regulation of blood coagulationGO:00301939.6F2, SERPINC1
5platelet activationGO:00301689.0CD40LG, F2, F8
6blood coagulationGO:00075968.8F2, F3, F8, SERPINC1
7hemostasisGO:00075998.7F2, F3, F8, SERPINC1

Molecular functions related to Fournier Gangrene according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1copper ion bindingGO:00055079.7ALB, F8
2serine-type endopeptidase activityGO:00042528.6F2, F3, F8

Sources for Fournier Gangrene

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet