Aliases & Classifications for Fournier Gangrene

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Aliases & Descriptions for Fournier Gangrene:

Name: Fournier Gangrene 45 65
 
Fournier's Gangrene 45

Classifications:



External Ids:

UMLS65 C0238419

Summaries for Fournier Gangrene

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NIH Rare Diseases:45 Fournier gangrene refers to the death of body tissue of the genitals and/or perineum. signs and symptoms of the condition include genital pain, tenderness, redness, and swelling with a rapid progression to gangrene. although the condition can affect men and women of all ages, it is most commonly diagnosed in adult males. most cases of fournier gangrene are caused by an infection in the genital area or urinary tract. people with impaired immunity (i.e. due to diabetes or hiv) have an increased susceptibility to the condition. treatment generally includes surgery and medications such as antibiotics and/or antifungal therapy. last updated: 2/25/2016

MalaCards based summary: Fournier Gangrene, also known as fournier's gangrene, is related to lateral sclerosis and tetanus. An important gene associated with Fournier Gangrene is CD40LG (CD40 Ligand), and among its related pathways are FOXA2 and FOXA3 transcription factor networks and Complement and coagulation cascades. Affiliated tissues include endothelial, thyroid and brain, and related mouse phenotypes are hematopoietic system and immune system.

Wikipedia:68 Fournier gangrene is a type of necrotizing fasciitis or gangrene usually affecting the perineum. It... more...

Related Diseases for Fournier Gangrene

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Diseases related to Fournier Gangrene via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 216)
idRelated DiseaseScoreTop Affiliating Genes
1lateral sclerosis30.6CD40LG, F2
2tetanus30.5ALB, F3
3myocardial infarction28.5ALB, CD40LG, F2, F3, F8, SERPINC1
4thyroiditis10.4
5breast cancer10.3
6neuronitis10.3
7mixed malaria10.3ALB, CD40LG
8somatoform disorder10.3ALB, CD40LG
9dermatitis10.3ALB, CD40LG
10weill-marchesani syndrome10.3ALB, CD40LG
11indolent myeloma10.3ALB, CD40LG
12subacute glomerulonephritis10.3ALB, CD40LG
13ileitis10.3ALB, CD40LG
14cerebellopontine angle primitive neuroectodermal10.3ALB, CD40LG
15angioedema10.3ALB, CD40LG
16arcus senilis10.3ALB, CD40LG
17peripheral artery disease10.3ALB, CD40LG
18liver failure acute infantile10.3CD40LG, F2
19autoimmune disease of blood10.3ALB, CD40LG
20small intestinal vasoactive intestinal peptide producing tumor10.3ALB, CD40LG
21blastomycosis10.3ALB, CD40LG
22splenic infarction10.3CD40LG, F2
23askin's tumor10.3ALB, F2
24primary progressive multiple sclerosis10.3ALB, CD40LG
25hemolytic-uremic syndrome10.3ALB, F2
26duodenogastric reflux10.2ALB, F2
27t cell deficiency10.2ALB, F2
28acute lymphoblastic leukemia, childhood10.2ALB, F2
29suppurative cholangitis10.2ALB, CD40LG
30iron deficiency anemia10.2ALB, F2
31multicentric reticulohistiocytosis10.2ALB, F2
32babesiosis10.2CD40LG, F3
33antiphospholipid syndrome10.2ALB, CD40LG
34acute cholangitis10.2ALB, F2
35commensal bacterial infectious disease10.2ALB, CD40LG
36adult endodermal sinus tumor10.2ALB, F8
37mental retardation, autosomal recessive 3510.2CD40LG, F3
38dysthymic disorder10.2F2, F8
39fallopian tube disease10.2ALB, F2
40moderately severe hemophilia a10.2F2, F8
41neuroblastoma10.2
42medullary thyroid carcinoma, familial10.2
43prostate cancer10.2
44hepatocellular carcinoma10.2
45asthma10.2
46coronary artery disease10.2
47lymphangioleiomyomatosis10.2
48atherosclerosis10.2
49hematopoietic stem cell transplantation10.2
50hepatitis10.2

Graphical network of the top 20 diseases related to Fournier Gangrene:



Diseases related to fournier gangrene

Symptoms for Fournier Gangrene

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Drugs & Therapeutics for Fournier Gangrene

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Drugs for Fournier Gangrene (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1AntibodiesPhase 24477
2Rho(D) Immune GlobulinPhase 2206
3Immunoglobulins, IntravenousPhase 2211
4Immunologic FactorsPhase 218483
5ImmunoglobulinsPhase 24477
6Immunoglobulin GPhase 2146
7
Daptomycinapproved, investigational83103060-53-316129629
Synonyms:
103060-53-3
AKOS005146218
C12013
C72H101N17O26
CHEBI:600103
CHEMBL508162
Cidecin
Cubicin
Cubicin (TN)
D01080
DAPTOMYCIN
Dapcin
Daptomicina
Daptomicina [Spanish]
Daptomycin
Daptomycin (JAN/USAN/INN)
Daptomycin [USAN:INN:BAN]
Daptomycine
 
Daptomycine [French]
Daptomycinum
Daptomycinum [Latin]
Deptomycin
LS-171846
LY 146032
LY-146032
LY146032
MK-3009
MolPort-003-846-138
N-Decanoyl-L-tryptophyl-L-asparaginyl-L-aspartyl-L-threonylglycyl-L-ornithyl-L-aspartyl-D-alanyl-L-aspartylglycyl-D-seryl-threo-3-methyl-L-glutamyl-3-anthraniloyl-L-alanine epsilon1-lactone
N-decanoyl-L-tryptophyl-D-asparaginyl-L-aspartyl-L-threonylglycyl-L-ornithyl-L-aspartyl-D-alanyl-L-aspartylglycyl-D-seryl-threo-3-methyl-L-glutamyl-3-anthraniloyl-L-alanine 1.13-3.4-lactone
N-decanoyl-L-tryptophyl-D-asparaginyl-L-aspartyl-L-threonylglycyl-L-ornithyl-L-aspartyl-D-alanyl-L-aspartylglycyl-D-seryl-threo-3-methyl-L-glutamyl-3-anthraniloyl-L-alanine epsilon(1)-lactone
N-decanoyl-L-tryptophyl-D-asparaginyl-N-[(3S,6S,9R,15S,18R,21S,24S,30S,31R)-3-[2-(2-aminophenyl)-2-oxoethyl]-24-(3-aminopropyl)-15,21-bis(carboxymethyl)-6-[(2R)-1-carboxypropan-2-yl]-9-(hydroxymethyl)-18,31-dimethyl-2,5,8,11,14,17,20,23,26,29-decaoxo-1-oxa-4,7,10,13,16,19,22,25,28-nonaazacyclohentriacontan-30-yl]-L-alpha-asparagine
N-decanoyl-L-tryptophyl-L-asparaginyl-N-[(3S,6S,9R,15S,18R,21S,24S,30S,31R)-3-[2-(2-aminophenyl)-2-oxoethyl]-24-(3-aminopropyl)-15,21-bis(carboxymethyl)-6-[(2R)-1-carboxypropan-2-yl]-9-(hydroxymethyl)-18,31-dimethyl-2,5,8,11,14,17,20,23,26,29-decaoxo-1-ox
N-decanoyl-L-tryptophyl-L-asparaginyl-N-[(3S,6S,9R,15S,18R,21S,24S,30S,31R)-3-[2-(2-aminophenyl)-2-oxoethyl]-24-(3-aminopropyl)-15,21-bis(carboxymethyl)-6-[(2R)-1-carboxypropan-2-yl]-9-(hydroxymethyl)-18,31-dimethyl-2,5,8,11,14,17,20,23,26,29-decaoxo-1-oxa-4,7,10,13,16,19,22,25,28-nonaazacyclohentriacontan-30-yl]-L-alpha-asparagine
UNII-NWQ5N31VKK
daptomycin
nchembio.184-comp5
8Anti-Bacterial Agents9140
9Anti-Infective Agents17220

Interventional clinical trials:

idNameStatusNCT IDPhase
1Phase III Efficacy and Safety Study of AB103 in the Treatment of Patients With Necrotizing Soft Tissue InfectionsRecruitingNCT02469857Phase 3
2Immunoglobulin for Necrotizing Soft Tissue Infections: a Randomised Controlled TrialActive, not recruitingNCT02111161Phase 2
3Biomarkers in Patients With Flesh-eating Bacterial InfectionsCompletedNCT02180906
4Daptomycin for the Treatment of Severe Necrotizing Soft-Tissue InfectionsCompletedNCT00261807
5Exploratory Study of Raised Serum Lactate as a Marker of Necrotizing FasciitisCompletedNCT01739959
6Modulation of Biomarkers in Patients With Flesh-eating Bacterial Infections After With Hyperbaric Oxygen TreatmentRecruitingNCT02501382

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Genetic Tests for Fournier Gangrene

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Anatomical Context for Fournier Gangrene

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MalaCards organs/tissues related to Fournier Gangrene:

33
Endothelial, Thyroid, Brain, Heart, Lung, T cells

Animal Models for Fournier Gangrene or affiliated genes

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MGI Mouse Phenotypes related to Fournier Gangrene:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053977.6CD40LG, F2, F3, F8, SERPINC1
2MP:00053877.3CD40LG, F2, F3, F8, SERPINC1
3MP:00053767.2ALB, CD40LG, F2, F3, F8, SERPINC1
4MP:00107687.1ALB, CD40LG, F2, F3, F8, SERPINC1

Publications for Fournier Gangrene

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Articles related to Fournier Gangrene:

(show top 50)    (show all 66)
idTitleAuthorsYear
1
MiR-195 suppresses non-small cell lung cancer by targeting CHEK1. (25840419)
2015
2
Vps33B is required for delivery of endocytosed cargo to lysosomes. (26403612)
2015
3
Dengue virus subgenomic RNA induces apoptosis through the Bcl-2-mediated PI3k/Akt signaling pathway. (24314632)
2014
4
Expression and role of BAG-1 in eosinophilic and non-eosinophilic chronic rhinosinusitis with nasal polyps. (24830325)
2014
5
Genetic variations in the androgen receptor are associated with steroid concentrations and anthropometrics but not with muscle mass in healthy young men. (24465978)
2014
6
Patrilineal background of esophageal cancer and gastric cardia cancer patients in a chaoshan high-risk area in china. (24339953)
2013
7
Effectiveness of chin-down posture to prevent tracheal aspiration in dysphagia secondary to acquired brain injury. A videofluoroscopy study. (22309385)
2012
8
Syringomyelia in preterm children with posthemorrhagic occlusive hydrocephalus. (22850824)
2012
9
Progression of solitary and multifocal papillary thyroid carcinoma - a retrospective study of 368 patients. (23253715)
2012
10
Membrane-type-3 matrix metalloproteinase (MT3-MMP) functions as a matrix composition-dependent effector of melanoma cell invasion. (22164270)
2011
11
Surgical treatment for scoliosis in patients with Shprintzen-Goldberg syndrome. (21307714)
2011
12
Beta interferon-mediated activation of signal transducer and activator of transcription protein 1 interferes with Rickettsia conorii replication in human endothelial cells. (21690236)
2011
13
Long-term corneal wavefront aberration variations after photorefractive keratectomy for myopia and myopic astigmatism. (21782383)
2011
14
Delayed response of indomethacin in patients with hemicrania continua: real or phantom headache? (19489876)
2010
15
CD40 is a regulator for vascular endothelial growth factor in the tumor microenvironment of glioma. (20303602)
2010
16
Imported bancroftian filariasis: diethylcarbamazine response and benzimidazole susceptibility of Wuchereria bancrofti in dynamic cross-border migrant population targeted by the National Program to Eliminate Lymphatic Filariasis in South Thailand. (19835831)
2010
17
Low bispectral index values in hydranencephaly. (19395974)
2009
18
Autoimmune optic neuritis in the common marmoset monkey: comparison of visual evoked potentials with MRI and histopathology. (18450589)
2008
19
A novel role of the sympatho-adrenergic system in regulating valve calcification. (17846318)
2007
20
Angiogenesis modulates adipogenesis and obesity. (17786229)
2007
21
Lack of extracellular signal-regulated kinase mitogen-activated protein kinase signaling shows a new type of melanoma. (17308088)
2007
22
The role of GABRA2 in risk for conduct disorder and alcohol and drug dependence across developmental stages. (16557364)
2006
23
Pulmonary hypertension triggered by lipopolysaccharide in ascites-susceptible and -resistant broilers is not amplified by aminoguanidine, a specific inhibitor of inducible nitric oxide synthase. (16553285)
2006
24
A live cell, image-based approach to understanding the enzymology and pharmacology of 2-bromopalmitate and palmitoylation. (17110192)
2006
25
Survey of the present status of sleep-disordered breathing in children with achondroplasia Part I. A questionnaire survey. (15763281)
2005
26
Selective angiotensin receptor antagonism with valsartan decreases arterial stiffness independently of blood pressure lowering in hypertensive patients. (16671331)
2005
27
Contagious bovine pleuropneumonia vaccines and control strategies: recent data. (15742622)
2004
28
Biphenyls as potent vitronectin receptor antagonists. Part 2: biphenylalanine ureas. (12643914)
2003
29
No association between the WNT2 gene and autistic disorder. (11840514)
2002
30
The tumour suppressor protein NF2/merlin: the puzzle continues. (11148074)
2001
31
Presynaptic inhibition caused by retrograde signal from metabotropic glutamate to cannabinoid receptors. (11516402)
2001
32
Hypereosinophilic syndrome and restrictive cardiomyopathy due to apical thrombi. (11447094)
2001
33
Pulmonary alveolar proteinosis in a dog. (11012120)
2000
34
beta-adrenergic mechanisms in cardiac diseases: a perspective. (11027943)
2000
35
Ex vivo assay to determine the cyclooxygenase selectivity of non-steroidal anti-inflammatory drugs. (10372826)
1999
36
Correlation of E-cadherin expression and recurrence of hepatocellular carcinoma. (10430370)
1999
37
Crystallization and preliminary X-ray crystallographic analysis of a Trichoderma reesei beta-mannanase from glycoside hydrolase family 5. (10216305)
1999
38
Nitric oxide inhibits HIV tat-induced NF-kappaB activation. (10393859)
1999
39
Mapping the subsite preferences of protein tyrosine phosphatase PTP-1B using combinatorial chemistry approaches. (9843364)
1998
40
27-bp deletion in the ret proto-oncogene as a somatic mutation associated with medullary thyroid carcinoma. (9587071)
1998
41
A vigorous virus-specific CD4+ T cell response may contribute to the association of HLA-DR13 with viral clearance in hepatitis B. (9717974)
1998
42
Free radicals induce reversible membrane-cytoplasm translocation of glyceraldehyde-3-phosphate dehydrogenase in human erythrocytes. (7544096)
1995
43
Exon 11 enhances insulin binding affinity and tyrosine kinase activity of the human insulin proreceptor. (7798270)
1994
44
Daniel's story: congenital central hypoventilation syndrome. (8121351)
1993
45
Use of cryotherapy in the treatment of keloids. (8509514)
1993
46
Steroid 21-hydroxylase deficiency: two additional mutations in salt-wasting disease and rapid screening of disease-causing mutations. (8518786)
1993
47
SchAPpf-Schulz-Passarge syndrome. (1637691)
1992
48
Use of ELISA to detect toxigenic Pasteurella multocida in atrophic rhinitis in swine. (1457544)
1992
49
HNF-1 alpha and HNF-1 beta (vHNF-1) share dimerization and homeo domains, but not activation domains, and form heterodimers in vitro. (2044952)
1991
50
Peptic ulcer: perforation and hemorrhage; choice of operation. (13367481)
1956

Variations for Fournier Gangrene

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Expression for genes affiliated with Fournier Gangrene

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Search GEO for disease gene expression data for Fournier Gangrene.

Pathways for genes affiliated with Fournier Gangrene

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GO Terms for genes affiliated with Fournier Gangrene

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Biological processes related to Fournier Gangrene according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1response to woundingGO:00096119.3F2, F3

Sources for Fournier Gangrene

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet