Fragile X Syndrome disease: Malacards - Research Articles, Symptoms, Drugs, Genes, Clinical Trials

MCID: FRG001 MIFTS: 67	Fragile X Syndrome malady Categories: Genetic diseases, Rare diseases, Neuronal diseases, Eye diseases, Endocrine diseases, Fetal diseases, Mental diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms Drugs Download this MalaCard Expand all tables

Aliases & Classifications for Fragile X Syndrome

Sources:
²³Genetics Home Reference, ⁴⁹OMIM, ¹⁰Disease Ontology, ¹¹diseasecard, ⁶⁸Wikipedia, ⁴⁵NIH Rare Diseases, ²²GeneTests, ⁴⁷Novoseek, ¹²DISEASES, ⁵¹Orphanet, ⁶⁷UniProtKB/Swiss-Prot, ³⁶MeSH, ³⁵MedlinePlus, ²CDC, ⁶⁵UMLS, ²⁴GTR, ²⁷ICD10, ²⁹ICD9CM, ⁴²NCIt, ⁵⁹SNOMED-CT, ²⁸ICD10 via Orphanet, ³⁷MESH via Orphanet, ⁶⁶UMLS via Orphanet, ³⁴MedGen, ⁶¹The Human Phenotype Ontology
See all MalaCards sources

Aliases & Descriptions for Fragile X Syndrome:

Name: Fragile X Syndrome ⁴⁹ ¹⁰ ¹¹ ⁶⁸ ⁴⁵ ²² ²³ ⁴⁷ ¹² ⁵¹ ⁶⁷ ³⁶ ³⁵ ² ⁶⁵

Martin-Bell Syndrome ¹⁰ ⁶⁸ ⁴⁵ ²² ²³ ⁵¹

Fraxa Syndrome ⁶⁸ ⁴⁵ ²³ ⁴⁷ ⁵¹ ⁶⁵

Fxs ⁶⁸ ⁴⁵ ²² ²³ ⁵¹ ²

Marker X Syndrome ¹⁰ ⁶⁸ ⁴⁵ ²² ²³

Fraxe Syndrome ⁴⁵ ²² ²³ ⁴⁷ ⁶⁵

X-Linked Mental Retardation and Macroorchidism ⁶⁸ ⁴⁵ ²³

Fragile Xe Syndrome ⁴⁵ ²³ ²⁴

Fra Syndrome ⁶⁸ ⁴⁵ ²³

X-Linked Mental Retardation Associated with Fragile Site Fraxe ⁴⁵ ²²

Fraxe Mental Retardation Syndrome ²² ²³

Fraxe Intellectual Disability ²³ ⁵¹

Frax ⁶⁷ ²⁴

Mental Retardation, X-Linked, Associated with Fragile Site Fraxe ²³

Intellectual Disability Associated with Fragile Site Fraxe ⁵¹

X-Linked Mental Retardation and Macro-Orchidism ⁴⁵

Mental Retardation, X-Linked, Fraxe Type ²³

Fragile X Mental Retardation Syndrome ¹⁰

Fragile Site, Folic Acid Type ⁴⁵

Fragile X Mental Retardation ²²

Fraxe Intellectual Deficit ²³

Frax Syndrome ⁵¹

Fraxa ²²

Characteristics:

Orphanet epidemiological data:

⁵¹

fragile x syndrome:
Inheritance: X-linked dominant; Prevalence: 1-5/10000 (Worldwide),1-5/10000 (Europe),1-9/100000 (United States),1-9/100000 (France),1-5/10000 (Spain),1-5/10000 (Canada); Age of onset: Childhood,Infancy,Neonatal; Age of death: normal life expectancy

fraxe intellectual disability:
Inheritance: X-linked recessive

HPO:

⁶¹

fragile x syndrome:
Onset and clinical course: incomplete penetrance
Inheritance: x-linked dominant inheritance

Classifications:

MalaCards categories:
Global: Genetic diseases, Rare diseases, Fetal diseases
Anatomical: Neuronal diseases, Eye diseases, Endocrine diseases, Mental diseases

See all MalaCards categories (disease lists)

ICD10: ²⁸ ²⁷

Congenital malformations, deformations and chromosomal abnormalities

Chromosomal abnormalities, not elsewhere classified

Other chromosome abnormalities, not elsewhere classified

Fragile X chromosome

Orphanet: ⁵¹

Rare neurological diseases

Rare eye diseases

Rare endocrine diseases

Developmental anomalies during embryogenesis

External Ids:

OMIM⁴⁹ 300624

Disease Ontology¹⁰ DOID:14261

ICD10²⁷ Q99.2

ICD9CM²⁹ 759.83

MeSH³⁶ D005600

NCIt⁴² C84717

SNOMED-CT⁵⁹ 390007001, 613003

Orphanet⁵¹ 908, 100973

ICD10 via Orphanet²⁸ Q99.2

MESH via Orphanet³⁷ D005600

UMLS via Orphanet⁶⁶ C0016667, C0751156

MedGen³⁴ C0016667, C2749126, C2749127

UMLS⁶⁵ C0016667, C0751156, C0751157

Summaries for Fragile X Syndrome

Sources:
¹⁰Disease Ontology, ⁴⁵NIH Rare Diseases, ⁶⁷UniProtKB/Swiss-Prot, ³⁵MedlinePlus, ²³Genetics Home Reference, ⁴⁹OMIM, ⁶⁸Wikipedia, ³³MalaCards
See all MalaCards sources

MedlinePlus:³⁵ Fragile x syndrome is the most common form of inherited developmental disability. a problem with a specific gene causes the disease. normally, the gene makes a protein you need for brain development. but the problem causes a person to make little or none of the protein. this causes the symptoms of fragile x. people with only a small change in the gene might not show any signs of fragile x. people with bigger changes can have severe symptoms. these might include intelligence problems, ranging from learning disabilities to severe intellectual disabilities social and emotional problems, such as aggression in boys or shyness in girls speech and language problems, especially in boys a genetic blood test can diagnose fragile x. there is no cure. you can treat some symptoms with educational, behavioral, or physical therapy, and with medicines. getting treatment early can help. nih: national institute of child health and human development

MalaCards based summary: Fragile X Syndrome, also known as martin-bell syndrome, is related to autism spectrum disorder and mental retardation, x-linked, fraxe type, and has symptoms including cognitive impairment, neurological speech impairment and pes planus. An important gene associated with Fragile X Syndrome is FMR1 (Fragile X Mental Retardation 1), and among its related pathways are GPCRs, Class C Metabotropic glutamate, pheromone and Hypothetical Network for Drug Addiction. Affiliated tissues include brain, testes and heart, and related mouse phenotypes are reproductive system and integument.

Disease Ontology:¹⁰ An X-linked disease that is characterized by moderate to severe mental retardation, macroorchidism, and distinct facial features, including long face, large ears, and prominent jaw, and has material basis in X-linked inheritance and a loss of FMR1 function.

NIH Rare Diseases:⁴⁵ Fragile x syndrome is a genetic condition involving changes in part of the x chromosome. this condition causes a range of developmental problems including learning disabilities and cognitive impairment. it is the most common form of inherited intellectual disability in males and a significant cause of intellectual disability in females. other signs and symptoms may include symptoms of autism spectrum disorders, seizures, and characteristic physical features. fragile x syndrome is caused by a change (mutation) in the fmr1 gene and is inherited in an x-linked dominant manner. there is no cure yet and treatment is based on the symptoms present in the person. early physical and education therapy is recommended. last updated: 5/12/2016

UniProtKB/Swiss-Prot:⁶⁷ Fragile X syndrome: Common genetic disease (has a prevalence of one in every 2000 children) which is characterized by moderate to severe mental retardation, macroorchidism (enlargement of the testicles), large ears, prominent jaw, and high-pitched, jocular speech. The defect in most fragile X syndrome patients results from an amplification of a CGG repeat region which is directly in front of the coding region.

Genetics Home Reference:²³ Fragile X syndrome is a genetic condition that causes a range of developmental problems including learning disabilities and cognitive impairment. Usually, males are more severely affected by this disorder than females.

OMIM:⁴⁹ Fragile X mental retardation is characterized by moderate to severe mental retardation, macroorchidism, and distinct... (300624) more...

Wikipedia:⁶⁸ Fragile X syndrome (FXS), also known as Martin-Bell syndrome, or Escalante\'s syndrome (more commonly... more...

Related Diseases for Fragile X Syndrome

Sources:
²⁰GeneCards, ¹⁹GeneAnalytics
See all MalaCards sources

Diseases in the Fragile X Syndrome family:

Fragile X Syndrome Type 1	Fragile X Syndrome Type 2
Fragile X Syndrome Type 3

Diseases related to Fragile X Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 78)

id	Related Disease	Score	Top Affiliating Genes
1	autism spectrum disorder	31.1	BDNF, EIF4E, FMR1, MECP2, SLC6A4
2	mental retardation, x-linked, fraxe type	12.5
3	fragile x syndrome type 1	12.0
4	fragile x syndrome type 2	12.0
5	fragile x syndrome type 3	12.0
6	symptomatic form of fragile x syndrome in female carrier	12.0
7	chromosome xq27.3-q28 duplication syndrome	10.9	FMR1, FRAXA
8	intellectual disability	10.7
9	premature ovarian failure 1	10.6	FMR1, FRAXA
10	inclusion body myopathy with paget disease of bone and frontotemporal dementia	10.6	FMR1, GRM5
11	autosomal dominant disease	10.5	FMR1, FXR1, FXR2, GRM5
12	deafness, dystonia, and cerebral hypomyelination	10.5	AFF2, FRAXE
13	spinocerebellar ataxia type 16	10.5	FMR1, GRM5
14	down syndrome	10.3
15	fragile x tremor/ataxia syndrome	10.3
16	autoimmune hepatitis	10.3	BDNF, FMR1, MECP2, SLC6A4
17	atopic dermatitis	10.3	BDNF, GRM1, GRM5, SLC6A4
18	candidiasis	10.3	BDNF, FMR1, GRM5, MECP2, SLC6A4
19	craniosynostosis, adelaide type	10.2	BDNF, FMR1, GRM5, MECP2, SLC6A4
20	ataxia	10.2
21	neuronitis	10.2
22	atypical autism	10.2	AFF2, BDNF, FMR1, MECP2, SLC6A4
23	tremor	10.2
24	fragile x-associated tremor/ataxia syndrome	10.1
25	bone fracture	10.1
26	premature ovarian failure	10.1
27	learning disability	10.0
28	colorectal cancer	10.0
29	autoimmune disease of skin and connective tissue	10.0	BDNF, FMR1, FXR1, FXR2, GRM5, MECP2
30	prader-willi syndrome	10.0
31	turner syndrome	10.0
32	attention deficit-hyperactivity disorder	9.9
33	friedreich ataxia	9.9
34	neurofibromatosis, type 1	9.9
35	anxiety disorder	9.9
36	cerebritis	9.9
37	neurofibromatosis	9.9
38	myotonic dystrophy	9.9
39	hepatocellular carcinoma	9.9
40	parkinson disease, late-onset	9.9	BDNF, GRM1, GRM5, SLC6A4
41	medulloblastoma	9.7
42	obesity	9.7
43	achondroplasia	9.7
44	cherubism	9.7
45	testicular microlithiasis	9.7
46	williams-beuren syndrome	9.7
47	werner syndrome	9.7
48	otitis media	9.7
49	costello syndrome	9.7
50	angelman syndrome	9.7

Graphical network of the top 20 diseases related to Fragile X Syndrome:

Symptoms for Fragile X Syndrome

Sources:
⁴⁹OMIM, ⁶¹The Human Phenotype Ontology, ⁵¹Orphanet, ⁶⁵UMLS
See all MalaCards sources

Symptoms by clinical synopsis from OMIM:

300624

Clinical features from OMIM:

300624

Symptoms:

⁵¹ (show all 27)

chronic/relapsing otitis
flat foot
macroorchidism/macrotestes
speech troubles/aphasia/dysphasia/echolalia/mutism/logorrhea/dysprosodia
intellectual deficit/mental/psychomotor retardation/learning disability
hyperextensible joints/articular hyperlaxity
x-linked dominant inheritance
fragile chromosome x site
macrocephaly/macrocrania/megalocephaly/megacephaly
frontal bossing/prominent forehead
narrow face
long face
prognathism/prognathia
nasal congestion/sinusitis/rhinitis/rhinorrhea

prominent/bat ears
gastroesophageal reflux/pyrosis/esophagitis/hiatal hernia/gastroparesia
hypotonia
hyperactivity/attention deficit
strabismus/squint
mitral valve prolapse/incompetence/insufficiency/regurgitation/ring anomaly
aortic root dilatation/dilation/aneurysm
cortical atrophy without hydrocephaly/cerebral hemiatrophy/subcortical atrophy
seizures/epilepsy/absences/spasms/status epilepticus
autism/autistic disoders
humour troubles/anxiety/depression/apathy/euphoria/irritability
psychosis/schizophrenia/maniac disorder
auto-aggressivity/auto-mutilation

HPO human phenotypes related to Fragile X Syndrome:

(show all 43)

id	Description	Frequency	HPO Source Accession
1	cognitive impairment	hallmark (90%)	HP:0100543
2	neurological speech impairment	hallmark (90%)	HP:0002167
3	pes planus	hallmark (90%)	HP:0001763
4	joint hypermobility	hallmark (90%)	HP:0001382
5	otitis media	hallmark (90%)	HP:0000388
6	macroorchidism	hallmark (90%)	HP:0000053
7	attention deficit hyperactivity disorder	typical (50%)	HP:0007018
8	intellectual disability, moderate	typical (50%)	HP:0002342
9	frontal bossing	typical (50%)	HP:0002007
10	muscular hypotonia	typical (50%)	HP:0001252
11	abnormality of the pinna	typical (50%)	HP:0000377
12	mandibular prognathia	typical (50%)	HP:0000303
13	long face	typical (50%)	HP:0000276
14	narrow face	typical (50%)	HP:0000275
15	macrocephaly	typical (50%)	HP:0000256
16	sinusitis	typical (50%)	HP:0000246
17	self-injurious behavior	occasional (7.5%)	HP:0100716
18	dilatation of the ascending aorta	occasional (7.5%)	HP:0005111
19	cerebral cortical atrophy	occasional (7.5%)	HP:0002120
20	abnormality of the mitral valve	occasional (7.5%)	HP:0001633
21	seizures	occasional (7.5%)	HP:0001250
22	autism	occasional (7.5%)	HP:0000717
23	strabismus	occasional (7.5%)	HP:0000486
24	congenital macroorchidism		HP:0008640
25	periventricular gray matter heterotopia		HP:0007165
26	folate-dependent fragile site at xq28		HP:0003564
27	scoliosis		HP:0002650
28	abnormal head movements		HP:0002457
29	macroorchidism, postpubertal		HP:0002050
30	large forehead		HP:0002003
31	pes planus		HP:0001763
32	mitral valve prolapse		HP:0001634
33	joint laxity		HP:0001388
34	seizures		HP:0001250
35	poor eye contact		HP:0000817
36	pectus excavatum		HP:0000767
37	hyperactivity		HP:0000752
38	autism		HP:0000717
39	macrotia		HP:0000400
40	mandibular prognathia		HP:0000303
41	coarse facial features		HP:0000280
42	long face		HP:0000276
43	macrocephaly		HP:0000256

UMLS symptoms related to Fragile X Syndrome:

agitation, head movements abnormal, joint laxity, seizures

Drugs & Therapeutics for Fragile X Syndrome

Sources:
⁴⁴NIH Clinical Center, ⁴ClinicalTrials, ⁶Cochrane Library, ⁶⁵UMLS, ⁴³NDF-RT, ¹³DrugBank, ²⁶HMDB, ⁹DGIdb, ⁵³PharmGKB, ³⁰IUPHAR, ⁴⁷Novoseek, ¹BitterDB
See all MalaCards sources

Drugs for Fragile X Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 83)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Riluzole

approved, investigational

Phase 4

1744-22-5

5070

Synonyms:

1744-22-5

2-Amino-6-(trifluoromethoxy)-benzothiazole

2-Amino-6-(trifluoromethoxy)benzothiazole

2-Amino-6-trifluoro- methoxybenzothiazole

2-amino-6-(trifluoromethoxy)-1,3-benzothiazole

2-amino-6-(trifluoromethoxy)benzo[d]thiazole

2-amino-6-(trifluoromethoxyl)benzothiazole

2-amino-6-trifluoromethoxybenzothiazole

6-(trifluoromethoxy)-1,3-benzothiazol-2-amine

6-(trifluoromethoxy)benzo[d]thiazol-2-amine

6-Trifluoromethoxy-benzothiazol-2-ylamine

6-trifluoromethoxybenzothiazole-2-yl-amine

AC-730

AC1L1JJL

AC1Q530H

AKOS000265071

ALBB-006046

Amino-2 trifluoromethoxy-6 benzothiazole

Amino-2 trifluoromethoxy-6 benzothiazole [French]

BB_SC-4839

BF-37

BIDD:GT0055

BPBio1_000037

BPBio1_000837

BRD-K21283037-001-02-5

BRD-K21283037-003-03-9

BSPBio_000033

Bio1_000416

Bio1_000905

Bio1_001394

Biomol-NT_000245

C07937

C8H5F3N2OS

CHEMBL744

CID5070

D00775

DB00740

EU-0101064

FT-0082997

HMS1773G08

HMS2089O19

HMS2094G07

I01-2084

LS-40688

Lopac-R-116

Lopac0_001064

MLS000069369

MolPort-000-151-262

NCGC00015882-01

NCGC00015882-02

NCGC00015882-03

NCGC00015882-07

NCGC00015882-11

NCGC00023141-02

NCGC00023141-04

NCGC00023141-05

NCGC00023141-06

PK-26124

PK-26124, RP-54274, Rilutek, Riluzole

Prestwick-03A08

Prestwick0_000167

Prestwick1_000167

Prestwick2_000167

Prestwick3_000167

R-116

R116_SIGMA

RP 54274

RP-54274

Rilutek

Rilutek (TN)

Riluzol

Riluzol [INN-Spanish]

Riluzole

Riluzole (JAN/USAN/INN)

Riluzole HCl

Riluzole Hydrochloride

Riluzole [USAN:INN]

Riluzolum

Riluzolum [INN-Latin]

S1614_Selleck

SMR000058231

SPBio_000599

SPBio_001954

STK503686

Spectrum2_000550

Tocris-0768

UNII-7LJ087RS6F

ZERO/001785

ZINC00006481

riluzole

Dopamine

approved

Phase 4

3084

62-31-7, 51-61-6

681

Synonyms:

(3H)-Dopamine

.Beta.-(3,4-Dihydroxyphenyl)ethylamine hydrochloride

.alpha.-(3,4-Dihydroxyphenyl)-.beta.-aminoethane

1,2-Benzenediol, 4-(2-aminoethyl)- (9CI)

1,2-Benzenediol, 4-(2-aminoethyl)-, hydrochloride

1,2-Benzenediol, 4-(2-aminoethyl)-, labeled with tritium

153C5321-5FEE-4B0B-8925-F388F0EEEBD1

2-(3,4-Dihydroxyphenyl)ethylamine

2-(3,4-dihydroxyphenyl)ethylamine

2-benzenediol

3,4-Dihydroxyphenethylamine

3,4-Dihydroxyphenethylamine hydrochloride

3,4-Dihydroxyphenylethylamine

3,4-dihydroxyphenethylamine

3-Hydroxtyramine

3-Hydroxytyramine

3-Hydroxytyramine Hydrobromide

3-Hydroxytyramine hydrochloride

4-(2-Aminoethyl)-1,

4-(2-Aminoethyl)-1,2-benzenediol

4-(2-Aminoethyl)-1,2-bezenediol

4-(2-Aminoethyl)-Pyrocatechol

4-(2-Aminoethyl)benzene-1,2-diol

4-(2-Aminoethyl)catechol

4-(2-Aminoethyl)pyrocatechol

4-(2-Aminoethyl)pyrocatechol hydrochloride

4-(2-aminoethyl)-pyrocatechol

50444-17-2

51-61-6

62-31-7 (HYDROCHLORIDE)

AC1L19S5

AC1Q54AX

AC1Q54AY

AKOS003790978

ASL 279

BIDD:ER0506

BPBio1_001123

BSPBio_001932

Biomol-NT_000001

C03758

CHEBI:18243

CHEMBL59

CID681

D07870

DB00988

Deoxyepinephrine

DivK1c_000780

Dopamin

Dopamina

Dopamina [INN-Spanish]

Dopamine

Dopamine (INN)

Dopamine (USAN)(*hydrochloride*)

Dopamine Hcl

Dopamine Hydrochloride

Dopamine [INN:BAN]

Dopaminum

Dopaminum [INN-Latin]

Dopastat

Dophamine

Dynatra

EINECS 200-110-0

HSDB 3068

Hydroxytyramin

Hydroxytyramine

IDI1_000780

IP 498

Intropin

Intropin [*hydrochloride*]

KBio1_000780

KBio2_001492

KBio2_002388

KBio2_002484

KBio2_004060

KBio2_004956

KBio2_005052

KBio2_006628

KBio2_007524

KBio2_007620

KBio3_001152

KBio3_002867

KBio3_002962

KBioGR_001129

KBioGR_002388

KBioGR_002484

KBioSS_001492

KBioSS_002393

KBioSS_002491

KW-3-060

L-DOPAMINE

L000232

LDP

LS-159

Lopac-H-8502

Lopac0_000586

Medopa (TN)

MolPort-001-641-000

NCGC00015519-01

NCGC00015519-08

NCGC00096050-01

NCGC00096050-02

NCGC00096050-03

NCGC00096050-04

NCGC00096050-05

NINDS_000780

NSC 173182

NSC169105

NSC173182

Oprea1_088821

Oxytyramine

Pyrocatechol, 4-(2-aminoethyl)- (8CI)

Pyrocatechol, 4-(2-aminoethyl)-, hydrochloride

Revimine

Revivan

SPBio_001205

SPECTRUM1505155

ST048774

STK301601

Spectrum2_001023

Spectrum3_000406

Spectrum4_000525

Spectrum5_000945

Spectrum_001012

UNII-VTD58H1Z2X

UPCMLD0ENAT5885989:001

a-(3,4-Dihydroxyphenyl)-b-aminoethane

alpha-(3,4-Dihydroxyphenyl)-beta-aminoethane

cMAP_000036

cMAP_000065

dopamine

hydroxytyramine

intropin

m-Hydroxytyramine hydrochloride

nchembio.105-comp9

nchembio.107-comp4

nchembio.284-comp1

nchembio.78-comp16

nchembio.89-comp3

nchembio705-8

nchembio801-comp8

Risperidone

approved, investigational

Phase 4

477

106266-06-2

5073

Synonyms:

106266-06-2

3-(2-(4-(6-Fluoro-1,2-benzisoxazol-3-yl)piperidino)ethyl)-6,7,8,9-tetrahydro-2-methyl-4H-pyrido(1,2-a)pyrimidin-4-one

3-(2-[4-(6-fluoro-benzo[d]isoxazol-3-yl)-piperidin-1-yl]-ethyl)-2-methyl-6,7,8,9-tetrahydro-pyrido[

3-(2-[4-(6-fluoro-benzo[d]isoxazol-3-yl)-piperidin-1-yl]-ethyl)-2-methyl-6,7,8,9-tetrahydropyrido[1,

3-[2-[-4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one

3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]-6,7,8,9-tetrahydro-2-methyl-4H-pyrido [1,2-a] pyrimidin-4-one

3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)piperi-dino]ethyl]-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]-pyrimidin-4-one

3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one

3-[2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl]-2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one

3-[2-[4-(6-fluoro-benzo[d]isoxazol-3-yl)-piperidin-1-yl]-ethyl]-2-methyl-6,7,8,9-tetrahydropyrido[1,

3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin-1-yl]-ethyl}-2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one

3-{2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidin-1-yl]ethyl}-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one

3-{2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl}-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one

AB00514010

AC-1306

AC1L1JJU

BIDD:GT0262

BRD-K53857191-001-04-5

BRN 4891881

Belivon

Bio-0092

Buspirone

C23H27FN4O2

CAS-106266-06-2

CHEBI:8871

CHEMBL85

CID5073

CPD000466323

Consta, Risperdal

D00426

D018967

DB00734

EU-0101074

HMS1571M19

HMS2051H07

HMS2089C22

HSDB 7580

I01-1156

Jsp000573

KS-1106

L000510

LS-134196

Lopac-R-118

MLS000759429

MLS001165758

MLS001424081

MolPort-002-885-858

NCGC00015883-01

NCGC00015883-02

NCGC00015883-03

NCGC00094352-01

NCGC00094352-02

NCGC00094352-03

NCGC00179257-01

Prestwick0_001029

Prestwick1_001029

R 62 766

R 64 766, Risperdal, Risperidone

R 64,766

R 64766

R-118

R-64,766

R-64-766

R-64766

R64,766

R64766

Rispen

Risperdal

Risperdal (TN)

Risperdal Consta

Risperdal M-Tab

Risperdal M-tab

Risperidal

Risperidal M-Tab

Risperidona

Risperidona [Spanish]

Risperidone

Risperidone (JAN/USAN/INN)

Risperidone (RIS)

Risperidone M-tab

Risperidone [USAN:BAN:INN]

Risperidone, placebo

Risperidonum

Risperidonum [Latin]

Risperin

Rispolept

Rispolin

S1615_Selleck

SAM001246595

SMR000466323

SPBio_003078

STK646402

Sequinan

Spiron

TL8000230

UNII-L6UH7ZF8HC

risperdone

risperidone

Methylphenidate

approved, investigational

Phase 4

364

113-45-1

4158

Synonyms:

.alpha.-Phenyl-2-piperidineacetic acid methyl ester

113-45-1

2-Piperidineacetic acid, .alpha.-phenyl-, methyl ester

2-Piperidineacetic acid, alpha-phenyl-, methyl ester

298-59-9 (hydrochloride)

4311/B Ciba

AC1L1HJM

C 4311

C07196

CHEBI:6887

CHEMBL796

CID4158

Calocain

Centedein

Centedrin

Centedrine

Centredin

Concerta

D-Methylphenidate HCl

D04999

DB00422

DB06701

DEA No. 1724

Daytrana

Daytrana (TN)

EINECS 204-028-6

Focalin

Focalin XR

HSDB 3126

L001307

LS-565

METHYLPHENIDATE (SEE ALSO: METHYLPHENIDATE HYDROCHLORIDE, CAS 298-59-9, NTPNO 10266-R)

MPH

Meridil

Metadate

Metadate CD

Metadate ER

MethyPatch

Methyl (2-phenyl-2-(2-piperidyl)acetate)

Methyl alpha-phenyl-alpha-(2-piperidyl)acetate

Methyl alpha-phenyl-alpha-2-piperidinylacetate

Methyl phenidate

Methyl phenidyl acetate

Methyl phenidylacetate

Methylfenidan

Methylin

Methylin ER

Methylofenidan

Methylphen

Methylphenidan

Methylphenidate

Methylphenidate (USAN/INN)

Methylphenidate HCl

Methylphenidate Hydrochloride

Methylphenidate [INN:BAN]

Methylphenidate hydrochloride

Methylphenidatum

Methylphenidatum [INN-Latin]

Methylphenidylacetate hydrochloride

Methypatch

Metilfenidat hydrochloride

Metilfenidato

Metilfenidato [INN-Spanish]

Metilfenidato [Italian]

MolPort-001-779-620

NCI-C56280

PMS-Methylphenidate

Phenidylate

Plimasine

Quillivant XR

Riphenidate

Ritalin

Ritalin LA

Ritalin SR

Ritalin hydrochloride

Ritalin-SR

Ritaline

Ritcher Works

Ritcher works

Tsentedrin

UNII-207ZZ9QZ49

alpha-Phenyl-2-piperidineacetic acid methyl ester

alpha-Phenyl-alpha-(2-piperidyl)acetic acid methyl ester

d-methylphenidate HCl

methyl 2-phenyl-2-piperidin-2-ylacetate

methyl phenyl(piperidin-2-yl)acetate

methylphenidate

nchembio.2007.55-comp28

Lovastatin

approved, investigational

Phase 4, Phase 2

75330-75-5

53232

Synonyms:

(1S,3R,7S,8S,8AR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-(2-(2R,4R)-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl)-1-naphthalenyl (S)-2-methyl-butyrate

1cqp

2beta,6alpha-Dimethyl-8alpha-(2-methyl-1-oxobutoxy)-mevinic acid lactone

6 Methylcompactin

6 alpha-Methylcompactin

6-Methylcompactin

6-alpha-Methylcompactin

6-alpha-methylcompactin

6alpha-Methylcompactin

6α-methylcompactin

71949-96-7

74133-25-8

75330-75-5

81739-26-6

AC-13961

AC1L1EI6

AC1Q2C7T

ACon0_000534

ACon1_000390

ARONIS24208

Altocor

Altoprev

Artein

BB_NC-1457

BIDD:GT0749

BIDD:PXR0113

BPBio1_000519

BRD-K09416995-001-06-8

BRN 3631989

BSPBio_000471

BSPBio_001265

BSPBio_003346

Belvas

C07074

C24H36O5

CCRIS 8092

CHEBI:40303

CHEMBL503

CID53232

CPD-5561

CPD000673570

Cholestra

Closterol

Colevix

D00359

D008148

DB00227

DivK1c_001032

HMS1569H13

HMS1792O07

HMS1923O13

HMS1990O07

HMS2089M06

HMS2093O03

HMS503O05

HSDB 6534

Hipolip

Hipovastin

I06-1876

IDI1_001032

KBio1_001032

KBio3_002848

L-154803

L0214

LOVASTATIN

LS-46359

Lestatin

Lipdip

Lipivas

Lipofren

Liposcler

Lovalip

Lovalord

Lovastatin

Lovastatin & Primycin

Lovastatin (USP/INN)

Lovastatin [USAN:BAN:INN]

Lovastatin, (1 alpha(S*))-Isomer

Lovastatin, 1 alpha-Isomer (without R*/S* notation)

Lovastatina

Lovastatina [Spanish]

Lovastatine

Lovastatine [French]

Lovastatinum

Lovastatinum [Latin]

Lovasterol

Lovastin

Lozutin

M2147_SIGMA

MEGxm0_000398

MK 803

MK-803

MK803

ML-530B

ML-530b

MLS000069585

MLS001055358

MSD 803

Mevacor

Mevacor (TN)

Mevinacor

Mevinolin

Mevinolin from Aspergillus sp.

Mevlor

MolPort-001-739-990

Monacolin K

Monacolin-K

Monakolin K

NCGC00023509-03

NCGC00023509-04

NCGC00023509-05

NCGC00023509-06

NCGC00023509-07

NCGC00023509-08

NINDS_001032

Nergadan

Paschol

Prestwick0_000516

Prestwick1_000516

Prestwick2_000516

Prestwick3_000516

Prestwick_819

Rextat

Rodatin

Rovacor

SAM002589963

SMR000058779

SMR000673570

SPBio_002392

SPECTRUM1503977

STK801953

Sivlor

Spectrum3_001873

Spectrum5_001294

Taucor

Tecnolip

Teroltrat

UNII-9LHU78OQFD

ZINC03812841

lovastatin

nchembio742-comp5

nchembio790-comp14

nchembio869-comp12

Excitatory Amino Acid Antagonists

Phase 4

1095

Neurotransmitter Uptake Inhibitors

Phase 4, Phase 2

2857

Anticonvulsants

Phase 4

2249

Excitatory Amino Acids

Phase 4

1109

Protective Agents

Phase 4, Phase 2

5651

Neuroprotective Agents

Phase 4, Phase 2

1376

Neurotransmitter Agents

Phase 4, Phase 2, Phase 1

14795

Dopamine Agents

Phase 4

3084

Dopamine Uptake Inhibitors

Phase 4

925

Hydroxymethylglutaryl-CoA Reductase Inhibitors

Phase 4, Phase 2

1804

Dihydromevinolin

Phase 4, Phase 2

Antimetabolites

Phase 4, Phase 2

9454

Central Nervous System Stimulants

Phase 4

1721

Hypolipidemic Agents

Phase 4, Phase 2

2228

L 647318

Phase 4, Phase 2

Anticholesteremic Agents

Phase 4, Phase 2

1732

Baclofen

approved

Phase 3, Phase 2

1134-47-0

2284

Synonyms:

( inverted question mark)-Baclofen

(+-)-Baclofen

(+/-)- beta-(Aminoethyl)-4- chlorobenzenepropanoic acid

(+/-)-BACLOFEN

(+/-)-beta-(Aminomethyl)-4-chlorobenzenepropanoic acid

(?)-Baclofen

1134-47-0

4-Amino-3-(4-chlorophenyl)butanoic acid

4-Amino-3-(4-chlorophenyl)butyric acid

62594-36-9

AB00051921

AC-4530

AC1L1DC6

ASTA Medica Brand of Baclofen

AWD, Baclofen

Alphapharm Brand of Baclofen

Apo Baclofen

Apo-Baclofen

ApoBaclofen

Apotex Brand of Baclofen

Ashbourne Brand of Baclofen

Athena Brand of Baclofen

Atrofen

B 5399

B3343

B5399_SIGMA

BPBio1_000012

BPBio1_000750

BRD-A84174873-001-05-2

BRN 2104494

BSPBio_000010

BSPBio_001880

Ba 34647

Ba-34,647

Ba-34647

Ba34,647

Ba34647

Baclofen

Baclofen (JP15/USP/INN)

Baclofen (R,S)

Baclofen AWD

Baclofen Alphapharm Brand

Baclofen Apotex Brand

Baclofen Ashbourne Brand

Baclofen Athena Brand

Baclofen Ciba-Geigy Brand

Baclofen Irex Brand

Baclofen Isis Brand

Baclofen Medtronic Brand

Baclofen Novartis Brand

Baclofen Nu-Pharm Brand

Baclofen Pharmascience Brand

Baclofen [USAN:INN:BAN:JAN]

Baclofene

Baclofene Irex

Baclofene [INN-French]

Baclofene-Irex

BaclofeneIrex

Baclofeno

Baclofeno [INN-Spanish]

Baclofenum

Baclofenum [INN-Latin]

Baclon

Baclophen

Baclospas

Benzenepropanoic acid, beta-(aminomethyl)-4-chloro-(9CI)

Biomol-NT_000251

C 34647Ba

C10H12ClNO2

CCRIS 3722

CHEBI:2972

CHEMBL701

CIBA-34,647-BA

CIBA34,647BA

CID2284

Chlorophenyl GABA

Ciba 34,647-Ba

Ciba Geigy Brand of Baclofen

Ciba-Geigy Brand of Baclofen

Clofen

D001418

D00241

DB00181

DL-4-Amino-3-P-chlorophenylbutanoic acid

DL-4-Amino-3-p-chlorophenylbutanoic acid

DL-Baclofen

DivK1c_000001

EINECS 214-486-9

EU-0100163

GABA, Chlorophenyl

Gabalon

Gablofen

Gen Baclofen

Gen-Baclofen

GenBaclofen

Genpharm

HMS1568A12

HMS1920E21

HMS2091M03

HMS500A03

I01-1934

IDI1_000001

Irex Brand of Baclofen

Isis Brand of Baclofen

KBio1_000001

KBio2_000466

KBio2_003034

KBio2_005602

KBio3_001380

KBioGR_000650

KBioSS_000466

Kemstro

Kemstro (TN)

L000002

LS-77134

Lebic

Lioresal

Lioresal (TN)

Lioresal Intrathecal

Lopac0_000163

MLS000028480

Medtronic Brand of Baclofen

MolPort-002-051-370

NCGC00015156-05

NCGC00015156-12

NCGC00023843-03

NCGC00024579-03

NCGC00024579-04

NCGC00024579-05

NCGC00024579-06

NINDS_000001

NSC329137

Novartis Brand of Baclofen

Nu Baclo

Nu Pharm Brand of Baclofen

Nu-Baclo

Nu-Baclofen

Nu-Pharm Brand of Baclofen

NuBaclo

Oprea1_440627

PCP-GABA

PMS Baclofen

PMSBaclofen

Pharmascience Brand of Baclofen

Pms-Baclofen

Prestwick0_000085

Prestwick1_000085

Prestwick2_000085

Prestwick3_000085

Prestwick_85

SMP1_000036

SMR000058294

SPBio_000044

SPBio_001949

SPECTRUM1500135

STK535284

STOCK2S-30552

Spectrum2_000092

Spectrum3_000310

Spectrum4_000245

Spectrum5_000852

Spectrum_000066

UNII-H789N3FKE8

UPCMLD-DP142

UPCMLD-DP142:001

baclofen

beta-(4-Chlorophenyl)gaba

beta-(Aminomethyl)-4-chlorobenzenepropanoic acid

beta-(Aminomethyl)-P-chlorohydrocinnamic acid

beta-(Aminomethyl)-p-chlorohydrocinnamic acid

beta-(P-Chlorophenyl)-gamma-aminobutyric acid

beta-(p-Chlorophenyl)-gamma-aminobutyric acid

gamma-Amino-beta-(P-chlorophenyl)butyric acid

gamma-Amino-beta-(p-chlorophenyl)butyric acid

Acamprosate

approved, investigational

Phase 3, Phase 2

77337-76-9

71158

Synonyms:

3-(Acetylamino)propanesulphonic acid

3-Acetamido-1-propanesulfonic acid

3-acetamidopropane-1-sulfonic acid

77337-70-3 (mono-hydrochloride salt)

77337-71-4 (mono-potassium salt)

77337-72-5 (mono-lithium salt)

77337-73-6 (calcium[2:1] salt)

77337-74-7 (magnesium[2:1] salt)

77337-76-9

AC1L2FNA

AC1Q1L6O

AC1Q6X8K

AOTA

AR-1H6082

Acamprosate

Acamprosate (INN)

Acamprosate 6473

Acamprosate Calcium

Acamprosate [INN:BAN]

Acamprosato

Acamprosato [INN-Spanish]

Acamprosatum

Acamprosatum [INN-Latin]

Aotal

Aotal (TN)

C5H11NO4S

CHEBI:51041

CID71158

Campral

D07058

DB00659

EINECS 278-667-4

HSDB 7358

LS-120940

N-Acetylhomotaurine

N-acetyl homotaurine

UNII-N4K14YGM3J

acamprosate

acamprosate (Campral)

acamprostate

calcium acetyl homotaurinate

calcium acetylhomotaurinate

calcium acetylhomotaurine

sodium acetylhomotaurine

Phase 3, Phase 2

Aripiprazole

approved, investigational

Phase 2

342

129722-12-9

60795

Synonyms:

129722-12-9

24-29-3

7-(4-(4-(2,3-Dichlorophenyl)-1-piperazinyl)butoxy)-3,4-dihydro-2(1H)-quinolinone

7-(4-(4-(2,3-Dichlorophenyl)-1-piperazinyl)butoxy)-3,4-dihydrocarbostyril

7-(4-(4-(2,3-Dichlorophenyl)-1-piperazinyl)butyloxy)-3,4-dihydro-2(1H)-quinolinone

7-[4-[4-(2,3-Dichlorophenyl)-1-piperazinyl]butoxy]-3,4-dihydrocarbostyril

7-[4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy]-3,4-dihydro-1H-quinolin-2-one

7-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy}-3,4-dihydroquinolin-2(1H)-one

AC-1554

AC1L1TXZ

AC1Q3T38

ALKS-9070

Abilify

Abilify (TN)

Abilify DISCMELT

Abilify Discmelt

Abilify Maintena

Abilitat

Aripiprazol

Aripiprazole

Aripiprazole (JAN/USAN/INN)

Aripiprazole [USAN]

Aripiprazolum

Aripirazole

Arpizol

Asprito|

BMS-337039

Bio-0004

Bristol-Myers Squibb brand of aripiprazole

C094645

C12564

C23H27Cl2N3O2

CHEBI:31236

CHEMBL1112

CID60795

CPD000466383

D01164

DB01238

Discmelt

FT-0082572

HMS2051I18

HMS2089M20

HMS2093F22

HSDB 7320

KS-1030

L001339

LS-142666

MLS000759517

MLS001165779

MLS001195621

MLS001424078

MolPort-002-885-808

MolPort-003-844-657

NCGC00159510-02

NCGC00159510-03

OPC 31

OPC-14597

OPC-31

Opc 14597

Otsuka brand of aripiprazole

Pripiprazole

S06-0010

SAM001246750

SMR000466383

STK625160

TL8000707

TL80090184

UNII-82VFR53I78

aripiprazol

aripiprazole

aripiprazolum

||OPC 14597

Donepezil

approved

Phase 2, Phase 1

271

120014-06-4

3152

Synonyms:

( inverted exclamation markA)-E 2020

1-Benzyl-4-[(5,6-dimethoxy-1-oxoindan-2-yl)methyl]piperidine

120014-06-4

2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one

2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxyindan-1-one

AB1004836

AC-6969

AC1L1FAE

AKOS000277311

Aricept

Aricept ODT

C24H29NO3

CHEBI:53289

CHEMBL502

CID3152

D07869

DB00843

Domepezil

Donaz

Donaz (TN)

Donepezil

Donepezil (INN)

Donepezil Hydrochloride

Donepezil [INN:BAN]

Donepezil hydrochloride

Donepezilo

Donepezilum

Eranz

I06-0343

KBio2_002144

KBio2_004712

KBio2_007280

KBioSS_002144

LS-81819

MolPort-000-881-588

MolPort-003-847-014

NCGC00167537-01

Oprea1_188452

Spectrum5_001662

Spectrum_001664

TL8000531

UNII-8SSC91326P

Sertraline

approved

Phase 2

282

79617-96-2

68617

Synonyms:

(+)-Sertraline

(1S,4S)-4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-amine

(1S,4S)-Sertraline

(1S-cis)-1,2,3,4-Tetrahydro-4-(3,4-dichlorophenyl)-N-methyl-1-naphthalenamine

(1S-cis)-4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphthalenamine

79559-97-0 (Hydrochloride)

79617-96-2

AB00514002

AB1004870

AC-15639

AC1L2A41

AC1Q3O5N

AC1Q3XJU

Apo-Sertraline

BIDD:GT0768

BIDD:PXR0193

BPBio1_001285

BRD-K82036761-003-02-1

BRN 5753709

BSPBio_001167

BSPBio_002698

C07246

C17H17Cl2N

CHEBI:9123

CHEMBL809

CID68617

CP 51974

Cp 51974

D02360

DB01104

DB08567

FT-0081122

HSDB 7037

KBio3_001918

KBioGR_001724

LS-94179

Lustral

MLS001195647

MLS002222308

MolPort-002-885-860

NCGC00092386-03

NCGC00092386-04

NCGC00092386-05

NCGC00092386-06

NCGC00092386-07

NCGC00092386-08

NCGC00092386-09

Prestwick3_001014

SMR000596516

SPBio_000385

SRE

Sertralina

Sertralina [Spanish]

Sertraline

Sertraline (INN)

Sertraline Hydrochloride

Sertraline [INN:BAN]

Sertraline [Zoloft]

Sertraline hydrochloride

Sertralinum

Sertralinum [Latin]

Spectrum2_000493

Spectrum3_001079

Spectrum4_001232

Sultamicillin Tosylate

UNII-QUC7NX6WMB

Zoloft

cis-(+)-Sertraline

sertraline

sertraline (Zoloft)

Minocycline

approved, investigational

Phase 2

173

10118-90-8

5281021

Synonyms:

(2Z,4S,4aS,5aR,12aS)-2-[amino(hydroxy)methylidene]-4,7-bis(dimethylamino)-10,11,12a-trihydroxy-4a,5,5a,6-tetrahydro-4H-tetracene-1,3,12-trione

(4S,4AS,5AR,12AS)-4,7-BIS(DIMETHYLAMINO)-3,10,12,12A-TETRAHYDROXY-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDROTETRACENE-2-CARBOXAMIDE

(4S,4AS,5ar,12as)-4,7-bis(dimethylamino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide

10118-90-8

13614-98-7 (mono-hydrochloride)

4,7-Bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-2-naphthacenecarboxamide

4708-96-7

7-Dimethylamino-6-demethyl-6-deoxytetracycline

AC1NQXWM

Arestin

BRN 3077644

Bio-0062

Borymycin

C07225

C23H27N3O7

CHEBI:50694

CHEBI:529981

CHEMBL1434

CHEMBL259172

CID5281021

CL 59806

CRL-1605 & Minocycline

D05045

Dynacin

HMS2090D03

HSDB 3130

LMPK07000002

LS-93850

Lactoferrin B & Minocycline

Lactoferrin H & Minocycline

MINO

MIY

Minociclina

Minociclina [INN-Spanish]

Minociclinum

Minocin

Minocin (Hydrochloride)

Minocline

Minocyclin

Minocycline

Minocycline (USAN/INN)

Minocycline Hydrochloride

Minocycline Monohydrochloride

Minocycline [USAN:BAN:INN]

Minocyclinum

Minocyclinum [INN-Latin]

NCGC00178854-01

NSC 141993

NSC141993

Solodyn

UNII-FYY3R43WGO

Vectrin (Hydrochloride)

Ximino

minociclinum

minocycline

nchembio.559-comp1

Oxytocin

approved

Phase 2

366

50-56-6

439302, 53477758

Synonyms:

(2S)-1-[(4R,7S,10S,13S,16S,19R)-19-amino-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-[(2S)-butan-2-yl]-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]-N-[(2S)-1-[(2-amino-2-oxoethyl)amino]-4-methyl-1-oxopentan-2-yl]pyrrolidine-2-carboxamide

(Arg8)-Vasopressin

(Arg8)-Vasotocin

1-({(4R,7S,10S,13S,16S,19R)-19-amino-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-16-(4-hydroxybenzyl)-13-[(1S)-1-methylpropyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosan-4-yl}carbonyl)-L-prolyl-L-leucylglycinamide

50-56-6

AC1L9735

Argipressin

Argpressin Acetate

BCBcMAP01_000094

Biotinyl-(Arg8)-Vasopressin

C00746

CHEBI:492195

CHEBI:7872

CHEMBL395429

CID439302

Cys-Tyr-Ile-Gln-Asn-Cys-Pro-Arg-Gly-NH2

Cys-Tyr-Ile-Gln-Asn-Cys-Pro-Leu-Gly-NH2

Cys-Tyr-Ile-Thr-Asn-Cys-Gly-Leu-Gly-NH2

Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Arg-Gly-NH2

Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Lys-Gly-NH2

D00089

Disulfide bridge Cys1-Cys6

Gly-Leu-Pro-c

HS-2021

L-Cysteinyl-L-tyrosyl-L-isoleucyl-L-glutaminyl-L-asparaginyl-L-cysteinyl-L-prolyl-L-leucylglycinamide cyclic(1-6)-disulfide

MolPort-003-938-941

NCGC00167132-01

O3251_SIGMA

O4375_SIGMA

OXT

OXYTOCIN

Ocytocin

Oxitocina

Oxytocic hormone

Oxytocin

Oxytocin (JP15/USP/INN)

Oxytocin (TN)

Oxytocin 10 Usp Units In Dextrose 5%

Oxytocin 20 Usp Units In Dextrose 5%

Oxytocin 5 Usp Units In Dextrose 5%

Oxytocin Acetate

Oxytocin injection

Oxytocine

Oxytocinum

Pitocin

Pitocin (TN)

SID29217903

SID50111741

Syntocinon

Syntocinon (TN)

TI-001

alpha-Hypophamine

nchembio.184-comp2

Vitamin C

approved, nutraceutical

Phase 2

424

50-81-7

5785, 54670067

Synonyms:

(+)-Sodium L-ascorbate

(+)-ascorbate

(+)-ascorbic acid

(2R)-2-[(1S)-1,2-Dihydroxyethyl]-4,5-dihydroxy-furan-3-one

(2R)-2-[(1S)-1,2-dihydroxyethyl]-4,5-dihydroxyfuran-3-one

(5R)-5-[(1S)-1,2-dihydroxyethyl]-3,4-dihydroxyfuran-2(5H)-one

129940-97-2

134-03-2 (monosodium salt)

14536-17-5

154170-90-8

2-(1,2-Dihydroxyethyl)-4,5-dihydroxyfuran-3-one

255564_SIAL

259133-78-3

3-Keto-L-gulofuranolactone

3-Oxo-L-gulofuranolactone

3-Oxo-L-gulofuranolactone (enol form)

30208-61-8

33034_RIEDEL

33034_SIAL

47863_SUPELCO

47A605F0-4187-47A8-B0CE-F9E7DA1B0076

50-81-7

50976-75-5

56172-55-5

56533-05-2

57304-74-2

57606-40-3

623158-95-2

6730-29-6

882690-91-7

884381-69-5

885512-24-3

88845-26-5

89924-69-6

95209_FLUKA

95209_SIGMA

95210_FLUKA

95210_SIAL

95212_FLUKA

A0278_SIGMA

A0537

A2174_SIGMA

A2218_SIGMA

A2343_SIGMA

A4403_SIGMA

A4544_SIGMA

A5960_SIGMA

A7506_SIGMA

A92902_ALDRICH

A92902_SIAL

AB00376923

AB1002440

AC1L1L4T

AC1Q77S6

AR-1J3435

Acid Ascorbic

Acide ascorbique

Acide ascorbique [INN-French]

Acido ascorbico

Acido ascorbico [INN-Spanish]

Acidum ascorbicum

Acidum ascorbicum [INN-Latin]

Acidum ascorbinicum

Adenex

Allercorb

Ambap36431-82-0

Antiscorbic Vitamin

Antiscorbic vitamin

Antiscorbutic Vitamin

Antiscorbutic factor

Antiscorbutic vitamin

Arco-Cee

Arco-cee

Ascoltin

Ascoltin (TN)

Ascor-B.I.D.

Ascorb

Ascorbajen

Ascorbate

Ascorbic Acid

Ascorbic Acid, Monosodium Salt

Ascorbic acid

Ascorbic acid (JP15/USP/INN)

Ascorbic acid [BAN:INN:JAN]

Ascorbic acid [INN:BAN:JAN]

Ascorbicab

Ascorbicap

Ascorbicap (TN)

Ascorbicin

Ascorbin

Ascorbinsaeure

Ascorbutina

Ascorbyl radical

Ascorin

Ascorteal

Ascorvit

BPBio1_000363

BSPBio_000329

Babor Baborganic Biological Enzyme Cleanser

C-Level

C-Long

C-Quin

C-Span

C-Vimin

C00072

C6H8O6

CCRIS 57

CE-VI-Sol

CHEBI:29073

CHEMBL196

CID5785

Cantan

Cantaxin

Caswell No. 061B

Catavin C

Ce Lent

Ce lent

Ce-Mi-Lin

Ce-mi-lin

Ce-vi-sol

Cebicure

Cebid

Cebion

Cebione

Cecon

Cee-Caps TD

Cee-Caps Td

Cee-Vite

Cee-caps TD

Cee-vite

Cegiolan

Ceglion

Ceklin

Celaskon

Celin

Cell C

Cemagyl

Cemill

Cenetone

Cenolate

Cereon

Cergona

Cescorbat

Cetamid

Cetane

Cetane-Caps TC

Cetane-Caps TD

Cetane-Caps Tc

Cetane-Caps Td

Cetane-caps TC

Cetane-caps TD

Cetebe

Cetemican

Cevalin

Cevatine

Cevex

Cevi-Bid

Cevi-bid

Cevimin

Cevital

Cevitamate

Cevitamic Acid

Cevitamic acid

Cevitamin

Cevitan

Cevitex

Cewin

Chewcee

Ciamin

Cipca

Citriscorb

Citrovit

Colascor

Concemin

Cortalex

D00018

DB00126

Davitamon C

Dora-C-500

Duoscorb

EINECS 200-066-2

FEMA No. 2109

Ferancee

Ferrous ascorbate

HSDB 818

HiCee

Hicee

Hybrin

IDO-C

Ido-C

Iron(II) ascorbate

Iron-ascorbic acid complexes

Juvamine

Kangbingfeng

Kyselina Askorbova

Kyselina askorbova

Kyselina askorbova [Czech]

L(+)-Ascorbate

L(+)-Ascorbic acid

L-(+)-Ascorbate

L-(+)-Ascorbic Acid

L-(+)-Ascorbic acid

L-(+)-ascorbic acid

L-3-Ketothreohexuronic acid lactone

L-3-ketothreohexuronic acid

L-Ascorbate

L-Ascorbic Acid

L-Ascorbic acid

L-Ascorbic acid, free radical form

L-Lyxoascorbate

L-Lyxoascorbic Acid

L-Lyxoascorbic acid

L-Threo-ascorbic acid

L-Threoascorbic acid

L-Xyloascorbate

L-Xyloascorbic Acid

L-Xyloascorbic acid

L-ascorbate

L-threo-Hex-2-enonic acid, gamma-lactone

L-threo-ascorbic acid

L-threo-hex-2-enono-1,4-lactone

LS-145

Laroscorbine

Lemascorb

Liqui-Cee

Liqui-cee

MLS002153776

Magnesium Ascorbicum

Magnorbin

Meri-C

Meri-c

MolPort-001-792-501

Monodehydroascorbic acid

NCGC00091517-01

NCGC00091517-02

NCGC00164357-01

NCI-C54808

NSC 33832

Natrascorb

Natrascorb injectable

Oral Vitamin C

Planavit C

Prestwick3_000325

Proscorbin

Redoxon

Ribena

Ronotec 100

Rontex 100

Roscorbic

Rovimix C

SMR001233160

Scorbacid

Scorbu C

Scorbu-C

Secorbate

Semidehydroascorbate

Sodascorbate

Sodium Ascorbate (Ascorbic Acid)

Stuartinic

Suncoat VC 40

Sunkist

Testascorbic

Tolfrinic

UNII-PQ6CK8PD0R

VASC

Vicelat

Vicin

Vicomin C

Viforcit

Viscorin

Viscorin 100M

Vitace

Vitacee

Vitacimin

Vitacin

Vitamin C

Vitamin- C

Vitamin-?C

Vitamisin

Vitascorbol

W210901_ALDRICH

Xitix

antiscorbic vita min

ascor-b.i.d

ascorbate

ascorbic acid

bmse000182

cee-caps td

cevibid

component of Cortalex

component of E and C-Level

component of Endoglobin Forte

component of Ferancee

e 300

e-300

e300

gamma-Lactone L-threo-Hex-2-enonate

gamma-Lactone L-threo-Hex-2-enonic acid

l-ascorbic acid

l-threo-hex-1-eofuranos-3-ulose

nchembio.174-comp5

nchembio.89-comp1

nchembio.92-comp2

nchembio821-comp9

roscorbi c

vitamin C

Vitamin E

approved, nutraceutical

Phase 2

371

59-02-9

14985

Synonyms:

(+)-a-Tocopherol

(+)-alpha-Tocopherol

(+)-alpha-tocopherol

(+)-α-tocopherol

(2R)-2,5,7,8-TETRAMETHYL-2-[(4R,8R)-4,8,12-trimethyltridecyl]chroman-6-ol

(2R)-3,4-Dihydro-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-2H-1-benzopyran-6-ol

(2R,4'R,8'R)-a-Tocopherol

(2R,4'R,8'R)-alpha-Tocopherol

(2R,4'R,8'r)-alpha-tocopherol

(R,R,R)-a-Tocopherol

(R,R,R)-alpha-Tocopherol

(R,R,R)-alpha-tocopherol

(R,R,R)-α-tocopherol

5,7,8-Trimethyltocol

Amino-Opti-E

Aquasol E

D-alpha-Tocopherol

Daltose

Denamone

E-200 I.U. Softgels

E-Complex-600

E-Ferol

E-Vitamin succinate

Eprolin

Gordo-Vite E

Phytogermin

Phytogermine

RRR-alpha-tocopherol

RRR-alpha-tocopheryl

Tocopherol

Vitamin E

Vitamin Ea

Vitamin Plus E Softgells

Vitamin e

Vitec

a-D-Tocopherol

a-Tocopherol

alpha-Tocopherol

alpha-delta-Tocopherol

d-alpha-tocopherol

d-α-tocopherol

delta-alpha-Tocopherol

Pyridoxine

approved, nutraceutical

Phase 2

165

65-23-6

1054

Synonyms:

(5-hydroxy-4,6-dimethylpyridin-3-yl)methyl phosphate

12001-78-4

2-Methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine

2-Methyl-3-hydroxy-4,5-di(hydroxymethyl)pyridine

2-Methyl-3-hydroxy-4,5-dihydroxymethyl-pyridin

2-Methyl-3-hydroxy-4,5-dihydroxymethyl-pyridin [German]

2-Methyl-3-hydroxy-4,5-dihydroxymethylpyridine

2-Methyl-4,5-bis(hydroxymethyl)-3-hydroxypyridine

2-methyl-3-hydroxy-4,5-bis(hydroxy-methyl) pyridine

2-methyl-3-hydroxy-4,5-dihydroxymethylpyridine

2-methyl-4,5-dimethylol-pyridin-3-ol

2B3E07D2-E4CC-4CC5-B085-6070BA01F9F0

3,4-Pyridinedimethanol, 5-hydroxy-6-methyl-, hydrochloride

3-Hydroxy-2-Picoline-4,5-dimethanol

3-Hydroxy-4,5-dihydroxymethyl-2-methylpyridine hydrochloride

3-Hydroxy-4,5-dimethylol-.alpha.-picoline hydrochloride

3-Hydroxy-4,5-dimethylol-alpha-picoline

3-Hydroxy-4,5-dimethylol-alpha-picoline hydrochloride

3-hydroxy-4,5-bis(hydroxymethyl)-2-methylpyridine

4,5-Bis(hydroxymethyl)-2-methyl-3-pyridinol

4,5-Bis(hydroxymethyl)-2-methylpyridin-3-ol hydrochloride

4,5-bis(hydroxymethyl)-2-methyl-3-pyridinol hydrochloride

4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol

4,5-bis(hydroxymethyl)-2-methylpyridine-3-ol

4-Deoxypyridoxine 5'-phosphate

47862_SUPELCO

5-Hydroxy-6-methyl-3,4-pyridinedicarbinol hydrochloride

5-Hydroxy-6-methyl-3,4-pyridinedimethanol

5-Hydroxy-6-methyl-3,4-pyridinedimethanol hydrochloride

5-Hydroxy-6-methyl-3,4-pyridinedimethanol, hydrochloride

58-56-0

58-56-0 (HCL)

58-56-0 (hydrochloride)

65-23-6

65-23-6 (Parent)

8059-24-3

85078-23-5

AC-12024

AC-14512

AC-907/25014218

AC1L1AMH

AC1L1LMI

AC1L2XK2

AC1Q22HP

AC1Q2G66

AC1Q3F63

AI3-19016

AIDS-006784

AIDS006784

AR-1A6363

AR-1J1632

Adermin hydrochloride

Adermine

Adermine hydrochloride

Aderomine hydrochloride

Aderoxin

Aderoxine

Alestrol

BB_NC-0050

BIDD:PXR0180

BPBio1_000646

BSPBio_000586

Becilan

Beesix

Benadon

Bonasanit

C00314

C8H11NO3

CAS-58-56-0

CBDivE_015627

CCRIS 1903

CHEBI:16709

CHEBI:30961

CHEMBL1200756

CHEMBL1364

CID104817

CID1054

CID6019

CPD0-1221

Campoviton 6

Cernevit-12

D02179

D025101

D08454

DB00165

EINECS 200-386-2

EINECS 200-603-0

EINECS 232-503-8

Godabion

Gravidox

HMS1569N08

HMS2093L07

HSDB 1212

Hexa-Betalin

Hexa-Betalin (R)

Hexa-betalin (TN)

Hexabetalin

Hexabione hydrochloride

Hexavibex

Hexermin

Hexermine

Hexobion

Hydoxin

I02-1897

I02-2297

KST-1A8556

LS-134393

LS-187072

LS-2332

MLS001074329

MLS002153915

MolPort-002-137-856

MolPort-002-319-991

MolPort-005-933-330

NCGC00016261-01

NCGC00164317-01

NCGC00180946-01

NSC 36225

NSC36225

NSC36225 (HCL)

Nestrex

Oprea1_061614

P0561

P4722_SIAL

P5669_SIGMA

P6280_SIGMA

P8666_SIGMA

P9755_SIAL

PN HCl

PYRIDOXINE HYDROCHLORIDE

PYRIDOXINE HYDROCHLORIDE, U.S.P.

Paxadon

Piridossina

Piridossina [DCIT]

Piridoxina

Piridoxina [INN-Spanish]

Prestwick0_000623

Prestwick1_000623

Prestwick2_000623

Prestwick3_000623

Prestwick_925

Pydox

Pyridipca

Pyridox

Pyridoxin

Pyridoxin hydrochloride

Pyridoxine

Pyridoxine (INN)

Pyridoxine HCl

Pyridoxine Hydrochloride

Pyridoxine Hydrochloride (B6)

Pyridoxine [INN:BAN]

Pyridoxine chloride

Pyridoxine hydrochloride

Pyridoxine hydrochloride (JP15/USP)

Pyridoxine hydrochloride [USAN:JAN]

Pyridoxine hydrogen chloride

Pyridoxine monohydrochloride

Pyridoxine, hydrochloride

Pyridoxine-HCl Microencapsulated

Pyridoxinium chloride

Pyridoxinum

Pyridoxinum [INN-Latin]

Pyridoxinum hydrochloricum

Pyridoxinum hydrochloricum (Hungarian)

Pyridoxol

Pyridoxol hydrochloride

Pyridoxol, hydrochloride

Pyridoxolum

Rodex

Rodex (R)

Rodex TD

SMP2_000230

SMR000674613

SPBio_002805

STK177324

STOCK1N-08684

Spondylonal

Tex Six T.R.

TimTec1_000657

UNII-68Y4CF58BV

UNII-KV2JZ1BI6Z

Vitamin B 6

Vitamin B6

Vitamin B6-hydrochloride

Vitamin V6

Vitamin V6 (TN)

Vitamin-?B6

Vitamin-?B6 hydrochloride

Vitaped

WLN: T6NJ B1 CQ D1Q E1Q &GH

ZINC00049154

ZINC21983293

bmse000288

c1302

component of Alestrol

nchembio.93-comp1

pyridoxine

vitamin B6

Contraceptives, Oral

Phase 2

3734

Anti-Bacterial Agents

Phase 2

9140

Anti-Infective Agents

Phase 2

17220

Cholinergic Agents

Phase 2, Phase 1

3243

Cholinesterase Inhibitors

Phase 2, Phase 1

498

Nootropic Agents

Phase 2, Phase 1

604

Epigallocatechin gallate

Phase 2

989-51-5

65064

Synonyms:

(-)-Epigallocatechin gallat

(-)-Epigallocatechin gallate

(-)-Epigallocatechin-3-O-gallate

(-)-Epigallocatechol gallate

(-)-Epigallocatehin gallate

Catechin deriv.

EGCG

Epigallocatcchin Gallate

Epigallocate

Epigallocatechin 3-gallate

Epigallocatechin Gallate

Epigallocic acid

Galloyl-L-epigallocatechol

Tea catechin

Central Nervous System Depressants

Phase 2

10016

Estrogens

Phase 2

2144

Antipsychotic Agents

Phase 2

2130

Tranquilizing Agents

Phase 2

3597

Pharmaceutical Solutions

Phase 2

7004

Trace Elements

Phase 2

3900

Vitamins

Phase 2

3857

Tocotrienols

Phase 2

372

Tocopherols

Phase 2

376

Micronutrients

Phase 2

3901

Antidepressive Agents

Phase 2

2367

Interventional clinical trials:

(show top 50) (show all 60)

id	Name	Status	NCT ID	Phase
1	Riluzole in Fragile X Syndrome	Completed	NCT00895752	Phase 4
2	Combining Lovastatin and a Parent-Implemented Language Intervention for Fragile X Syndrome	Recruiting	NCT02642653	Phase 4
3	The Psychiatric and Cognitive Phenotypes in Velocardiofacial Syndrome	Recruiting	NCT00768820	Phase 4
4	Acamprosate in Youth With Fragile X Syndrome	Completed	NCT01300923	Phase 3
5	Efficacy and Safety Study of STX209 (Arbaclofen) for Social Withdrawal in Adolescents and Adults With Fragile X Syndrome	Completed	NCT01282268	Phase 3
6	Efficacy and Safety Study of STX209 (Arbaclofen) for the Treatment of Social Withdrawal in Children With Fragile X Syndrome	Completed	NCT01325220	Phase 3
7	Study of Acamprosate in Fragile x Syndrome	Recruiting	NCT01911455	Phase 2, Phase 3
8	Long-term, Safety and Tolerability Study of AFQ056 in Adolescent Patients With Fragile X Syndrome (Open-label)	Terminated	NCT01433354	Phase 2, Phase 3
9	An Open Label Extension Study in Subjects With Fragile X Syndrome	Terminated	NCT01555333	Phase 3
10	Safety and Efficacy of AFQ056 in Adolescent Patients With Fragile X Syndrome	Completed	NCT01357239	Phase 2
11	Safety and Efficacy of AFQ056 in Adult Patients With Fragile X Syndrome	Completed	NCT01253629	Phase 2
12	Safety and Efficacy Study of Antioxidants for the Treatment of the Fragile X Syndrome	Completed	NCT01329770	Phase 2
13	Effects of CX516 on Functioning in Fragile X Syndrome and Autism	Completed	NCT00054730	Phase 2
14	Trial of Sertraline to Treat Children With Fragile X Syndrome	Completed	NCT01474746	Phase 2
15	Safety, Tolerability and Efficacy Study of STX209 in Subjects With Fragile X Syndrome	Completed	NCT00788073	Phase 2
16	A Safety Study of NNZ-2566 in Patients With Fragile X Syndrome	Completed	NCT01894958	Phase 2
17	Double-blind Placebo Controlled Study of Oxytocin in Fragile X Syndrome	Completed	NCT01254045	Phase 2
18	Randomized Controlled Study of Donepezil in Fragile X Syndrome	Completed	NCT01120626	Phase 2
19	A Study of RO4917523 in Patients With Fragile X Syndrome	Completed	NCT01517698	Phase 2
20	A Study of RO4917523 in Pediatric Patients With Fragile X Syndrome	Completed	NCT01750957	Phase 2
21	A Study With RO4917523 in Patients With Fragile X Syndrome	Completed	NCT01015430	Phase 2
22	Open Label Study Investigating Safety and Efficacy of NPL2009 50 mg - 150 mg on Prepulse Inhibition Tests and Continuous Performance Tasks, Adults With Fragile X Syndrome	Completed	NCT00637221	Phase 1, Phase 2
23	Aripiprazole in Fragile X Syndrome	Completed	NCT00420459	Phase 2
24	Efficacy, Safety and Tolerability of AFQ056 in Fragile X Patients	Completed	NCT00718341	Phase 2
25	Estrogen Receptors Beta (ER-B) as Therapeutic Targets for the Improvement of Cognitive Performance in Fragile-X (TESXF)	Completed	NCT01855971	Phase 2
26	Effects of Social Gaze Training on Brain and Behavior in Fragile X Syndrome	Recruiting	NCT02616796	Phase 1, Phase 2
27	Ganaxolone Treatment in Children With Fragile X Syndrome	Active, not recruiting	NCT01725152	Phase 2
28	A 6-week, Study of MG01CI Low Dose and High Dose Compared With Placebo in Adults and Adolescents With Fragile X Syndrome	Active, not recruiting	NCT02126995	Phase 2
29	Treatment of Fragile-X Associated Tremor/Ataxia Syndrome (FXTAS) With Allopregnanolone	Enrolling by invitation	NCT02603926	Phase 2
30	Combined Treatment of Minocycline and Lovastatin to Treat Individuals With Fragile X Syndrome	Not yet recruiting	NCT02680379	Phase 2
31	Citocoline for Treatment of FXTAS	Not yet recruiting	NCT02197104	Phase 2
32	A Study to Assess the Tolerability of a Single Dose of STX107 in Adults With Fragile X Syndrome	Suspended	NCT01325740	Phase 2
33	An Open Label Extension Study of STX209 in Subjects With Fragile X Syndrome	Terminated	NCT01013480	Phase 2
34	Long-term, Safety, Tolerability and Efficacy Study of AFQ056 in Adult Patients With Fragile X Syndrome	Terminated	NCT01348087	Phase 2
35	Clinical Study to Assess the Pharmacokinetics, Safety and Tolerability of Single and Multiple Oral Doses of AFQ056 in Children With Fragile X Syndrome (FXS)	Completed	NCT01482143	Phase 1
36	An Open-Label Trial of Donepezil in Fragile X Syndrome	Completed	NCT00220584	Phase 1
37	A Single-Dose Study in Normal Volunteers to Assess the Safety, Tolerability and Pharmacokinetics of STX107	Completed	NCT00965432	Phase 1
38	A PET Brain Imaging Study of mGluR5 in Subjects With Neuropsychiatric Conditions	Recruiting	NCT00870974	Phase 1
39	Parents Resources for Decreasing the Incidence of Change Triggered Temper Outbursts	Recruiting	NCT02567357	Phase 1
40	Glutaminergic Transmission in Autism : Molecular Imaging Exploration	Not yet recruiting	NCT02719951	Phase 1
41	Trial of Minocycline to Treat Children With Fragile X Syndrome	Completed	NCT01053156
42	Add-on Pilot Trial of Minocycline to Treat Fragile X Syndrome	Completed	NCT00858689
43	Biomarker Testing and DNA Collection in Subjects Participating in Protocol 22001	Completed	NCT00823368
44	Biomarker and DNA Collection in Subjects Participating in Protocol 22003	Completed	NCT00892580
45	Brain Connectivity in Neurodevelopmental Disorders in Response to Treatment	Completed	NCT01364818
46	Examining Social, Emotional, and Cognitive Functioning in People With Fragile X and Down Syndromes	Completed	NCT00879515
47	Microarray Analysis in Syndromic Obesity	Completed	NCT01043198
48	Protein Synthesis in the Brain of Patients With Fragile X Syndrome	Recruiting	NCT00362843
49	Decisional Capacity and Informed Consent in Fragile X Syndrome	Recruiting	NCT02465931
50	Teaching Math Skills to Individuals With Fragile X Syndrome	Recruiting	NCT01204151

Search NIH Clinical Center for Fragile X Syndrome

Cochrane evidence based reviews: fragile x syndrome

Genetic Tests for Fragile X Syndrome

Sources:
²²GeneTests
See all MalaCards sources

Genetic tests related to Fragile X Syndrome:

id	Genetic test	Affiliating Genes
1	X-Linked Mental Retardation Associated with Fragile Site Fraxe²²	AFF2
2	Fragile X Syndrome²²	FMR1

Anatomical Context for Fragile X Syndrome

Sources:
³³MalaCards
See all MalaCards sources

MalaCards organs/tissues related to Fragile X Syndrome:

³³

Brain, Testes, Heart, Eye, Liver, Breast, Bone

Animal Models for Fragile X Syndrome or affiliated genes

Sources:
³⁸MGI
See all MalaCards sources

MGI Mouse Phenotypes related to Fragile X Syndrome:

³⁸

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	reproductive system	MP:0005389	9.4	BDNF, DICER1, FMR1, FXR1, FXR2, GRM1
2	integument	MP:0010771	9.4	BDNF, DICER1, FMR1, FXR2, GRIA1, GRM5
3	nervous system	MP:0003631	8.8	BDNF, CYFIP1, CYFIP2, DICER1, FMR1, FXR2
4	behavior/neurological	MP:0005386	8.6	BDNF, CYFIP1, CYFIP2, DICER1, FMR1, FXR1

Publications for Fragile X Syndrome

Sources:
⁵⁴PubMed
See all MalaCards sources

Articles related to Fragile X Syndrome:

(show top 50) (show all 777)

id	Title	Authors	Year
1	Language development in infants and toddlers with fragile x syndrome: change over time and the role of attention. (25715182)	Kover S.T.... Roberts J.E.	2015
2	Analysis of AGG interspersion of the FMR1 gene in fragile X syndrome]. (25636091)	Tang L.... Tao J.	2015
3	Fragile X syndrome: economic burden and health-related quality of life of patients and caregivers in France. (26369667)	Chevreul K.... des Portes V.	2015
4	Modulation of the GABAergic pathway for the treatment of fragile X syndrome. (25258535)	Lozano R.... Hagerman R.J.	2014
5	R-loops associated with triplet repeat expansions promote gene silencing in Friedreich ataxia and fragile X syndrome. (24787137)	Groh M.... Gromak N.	2014
6	The contribution of inhibitory interneurons to circuit dysfunction in Fragile X Syndrome. (25202236)	Cea-Del Rio C.A.... Huntsman M.M.	2014
7	A family with fragile X syndrome, Duchenne muscular dystrophy and ichthyosis transmitted by an asymptomatic carrier. (23574351)	Todorova A.... Mitev V.	2013
8	Electrocortical changes associated with minocycline treatment in fragile X syndrome. (23981511)	Schneider A.... Hessl D.	2013
9	Physiological arousal in autism and fragile x syndrome: group comparisons and links with pragmatic language. (24432860)	Klusek J.... Losh M.	2013
10	Implementation of a markerless motion analysis method to quantify hyperkinesis in males with fragile X syndrome. (24252602)	O'Keefe J.A.... Wimmer M.A.	2013
11	A neurodevelopmental perspective on the acquisition of nonverbal cognitive skills in adolescents with fragile X syndrome. (24138215)	Kover S.T.... Abbeduto L.	2013
12	Visual-spatial learning impairments are associated with hippocampal PSD-95 protein dysregulation in a mouse model of fragile X syndrome. (24323121)	Gandhi R.M.... Macleod L.S.	2013
13	FXTAS in an unmethylated mosaic male with fragile X syndrome from Chile. (24028275)	Santa MarA-a L.... Tassone F.	2013
14	Feasibility, reliability, and clinical validity of the Test of Attentional Performance for Children (KiTAP) in Fragile X syndrome (FXS). (22958782)	Knox A.... Berry-Kravis E.	2012
15	The role of glycogen synthase kinase-3 signaling in neurodevelopment and fragile X syndrome. (23071871)	Portis S.... Tan J.	2012
16	Genetic removal of p70 S6 kinase 1 corrects molecular, synaptic, and behavioral phenotypes in fragile X syndrome mice. (23083736)	Bhattacharya A.... Klann E.	2012
17	Behavioral phenotype of fragile X syndrome in adolescence and adulthood. (22264109)	Smith L.E.... Greenberg J.S.	2012
18	Behavioral features of Williams Beuren syndrome compared to Fragile X syndrome and subjects with intellectual disability without defined etiology. (21211940)	PAcrez-GarcA-a D.... Brun-Gasca C.	2011
19	Predisposition to epilepsy in fragile X syndrome: does the Val66Met polymorphism in the BDNF gene play a role? (21890420)	Tondo M.... Martorell L.	2011
20	Amygdala regulation of fear and emotionality in fragile X syndrome. (21893939)	Olmos-Serrano J.L.... Corbin J.G.	2011
21	The psychiatric presentation of fragile x: evolution of the diagnosis and treatment of the psychiatric comorbidities of fragile X syndrome. (21893938)	Tranfaglia M.R.	2011
22	Targeted treatments for fragile X syndrome. (21484200)	Berry-Kravis E.... Hervey C.	2011
23	ACOG Committee Opinion No. 469: Carrier screening for fragile X syndrome. (20859177)		2010
24	Associating neural alterations and genotype in autism and fragile x syndrome: incorporating perceptual phenotypes in causal modeling. (20872060)	Bertone A.... Cornish K.	2010
25	Side effects of minocycline treatment in patients with fragile X syndrome and exploration of outcome measures. (20687826)	Utari A.... Nguyen D.V.	2010
26	Using perceptual signatures to define and dissociate condition-specific neural etiology: autism and fragile X syndrome as model conditions. (20886276)	Bertone A.... Cornish K.	2010
27	Characterization and reversal of synaptic defects in the amygdala in a mouse model of fragile X syndrome. (20534533)	Suvrathan A.... Chattarji S.	2010
28	The role of DNA damage response pathways in chromosome fragility in Fragile X syndrome. (19465392)	Kumari D.... Usdin K.	2009
29	A distinct DNA-methylation boundary in the 5'- upstream sequence of the FMR1 promoter binds nuclear proteins and is lost in fragile X syndrome. (19853235)	Naumann A.... Doerfler W.	2009
30	Mutation spectra in fragile X syndrome induced by deletions of CGG*CCG repeats. (18957433)	Wells R.D.	2009
31	A review of mathematical learning disabilities in children with fragile X syndrome. (19213014)	Murphy M.M.	2009
32	Molecular analysis of Fragile X syndrome. (19806593)	Basehore M.J.... Friez M.J.	2009
33	Brief report: aggression and stereotypic behavior in males with fragile X syndrome--moderating secondary genes in a "single gene" disorder. (17340199)	Hessl D.... Hagerman R.J.	2008
34	Secondary medical diagnosis in fragile X syndrome with and without autism spectrum disorder. (18627038)	GarcA-a-Nonell C.... Hagerman R.J.	2008
35	The Epigenetics of Fragile X Syndrome. (18371387)	Warren S.T.	2007
36	Fragile-X syndrome and fragile X-associated tremor/ataxia syndrome: two faces of FMR1. (17166801)	Jacquemont S.... Leehey M.A.	2007
37	Mathematics learning disability in girls with Turner syndrome or fragile X syndrome. (16500739)	Murphy M.M.... Henry A.E.	2006
38	The fragile X syndrome: exploring its molecular basis and seeking a treatment. (16626504)	Bardoni B.... Khandjian E.W.	2006
39	Cognitive aspects in girls with fragile X syndrome]. (15011155)	Ferrando Lucas M.T.... Lopez Perez G.	2004
40	A step-wise diagnosis of fragile X syndrome in Taiwan. (15335113)	Huang Y.T.... Hwu W.L.	2004
41	Histone modifications depict an aberrantly heterochromatinized FMR1 gene in fragile x syndrome. (12232854)	Coffee B.... Reines D.	2002
42	Diagnosis of fragile X syndrome]. (12447811)	Glover G.... Carbonell P.	2001
43	Sequence-specific RNA binding by a Nova KH domain: implications for paraneoplastic disease and the fragile X syndrome. (10676814)	Lewis H.A.... Burley S.K.	2000
44	Preimplantation diagnosis for fragile X syndrome based on the detection of the non-expanded paternal and maternal CGG. (10660959)	Sermon K.... Liebaers I.	1999
45	Fragile X syndrome is less common than previously estimated. (9032640)	Morton J.E.... Bullock S.	1997
46	An atypical case of fragile X syndrome caused by a deletion that includes the FMR1 gene. (7726157)	Quan F.... Popovich B.W.	1995
47	Molecular predictors of cognitive involvement in female carriers of fragile X syndrome. (8301764)	Taylor A.K.... Hagerman R.J.	1994
48	Cytogenetic studies in fragile X syndrome]. (1437821)	Nowicki G.A.	1992
49	(17875869)
50	(22448528)

Genes related to Fragile X Syndrome

Sources:
²⁰GeneCards, ⁴⁹OMIM, ⁵Clinvar, ⁶⁷UniProtKB/Swiss-Prot, ⁵¹Orphanet, ¹²DISEASES, ⁴⁷Novoseek, ²²GeneTests
See all MalaCards sources

Genes related to Fragile X Syndrome (4 elite genes):

(show all 33)

- Elite gene

- Cancer Census gene in COSMIC

id	Symbol	Description	Score	Implication	PubmedIds
1	FMR1	Fragile X Mental Retardation 1	1333.88	Molecular basis known ⁴⁹ Pathogenic ⁵ Causative variation ⁶⁷ Causative germline mutation (loss of function) ⁵¹ DISEASES inferred ¹² Novoseek inferred ⁴⁷ GeneCards inferred via : Disorders, Publications, Summaries, Proteins, Variants (show sections)	7726157, 10331602, 11814427 more 10870330, 7670500, 9600241, 11449486, 10331599, 17259243, 18412117, 15377638, 10424820, 17932962, 9211186, 18181681, 11030419, 9375726, 8668200, 1302032, 8490650, 8559749, 9207038, 7513295, 10341296, 12447822, 17065172, 19099346, 11448936, 11246709, 7927336, 7688265, 20011099, 19804849, 19806593, 17170008, 11449488, 11142752, 9150432, 8862184, 8242066, 1878973, 19836446, 19460941, 19233246, 8730293, 8515814, 19844254, 18687414, 17428978, 16700053, 12633995, 12447821, 11450815, 9030614, 18832455, 16741913, 15330685, 12952862, 11431225, 10767339, 9391887, 8844089, 8069307, 8324827, 1307252, 1710175, 17850748, 14993603, 12232854, 9131013, 7943023, 8219287, 8213832, 7692601, 19193898, 15082225, 11992571, 10767313, 8503923, 8301764, 19097038, 19025200, 17666893, 12018775, 9384610, 9375856, 18163424, 17101793, 11262423, 11229516, 11019488, 10208166, 8842725, 10496225, 16055059, 10364521, 9659908, 1605194, 8197163
2	FRAXA	Fragile Site, Folic Acid Type, Rare, Fra(X)(Q27.3) A (Macroorchidism, Mental Retardation)	531.31	Molecular basis known ⁴⁹ Novoseek inferred ⁴⁷ GeneCards inferred via : Disorders, Publications (show sections)	15639835, 10799273, 1760838 more 14505067, 8588847, 8844056, 9032640, 11901818, 20190856, 9863601, 16258159, 12447811, 1618021, 7992687, 16010677, 17322660, 8033209, 8792815, 10850542, 7781128
3	AFF2	AF4/FMR2 Family Member 2	495.99	Causative germline mutation ⁵¹ Genetic Tests ²² DISEASES inferred ¹² Novoseek inferred ⁴⁷ GeneCards inferred via : Publications (show sections)	17506108, 14526173
4	FMR3	Fragile X Mental Retardation Associated 3	350.00	Causative germline mutation ⁵¹
5	GRM5	Glutamate Metabotropic Receptor 5	35.29	DISEASES inferred ¹² Novoseek inferred ⁴⁷ GeneCards inferred via : Publications (show sections)	18202092, 19117905, 19017149 more 17987523
6	CYFIP1	Cytoplasmic FMR1 Interacting Protein 1	33.57	DISEASES inferred ¹² Novoseek inferred ⁴⁷ GeneCards inferred via : Publications (show sections)	18805096
7	MECP2	Methyl-CpG Binding Protein 2	31.16	DISEASES inferred ¹² Novoseek inferred ⁴⁷ GeneCards inferred via : Publications (show sections)	15696166, 11309367
8	FXR2	FMR1 Autosomal Homolog 2	27.85	DISEASES inferred ¹² Novoseek inferred ⁴⁷ GeneCards inferred via : Publications (show sections)	10446811
9	FXR1	FMR1 Autosomal Homolog 1	27.45	DISEASES inferred ¹² Novoseek inferred ⁴⁷ GeneCards inferred via : Publications (show sections)	10446811, 18628314
10	GRM1	Glutamate Metabotropic Receptor 1	24.33	DISEASES inferred ¹² GeneCards inferred via : Publications (show sections)
11	GRIA1	Glutamate Ionotropic Receptor AMPA Type Subunit 1	24.16	DISEASES inferred ¹² GeneCards inferred via : Publications (show sections)
12	TSPAN7	Tetraspanin 7	24.15	DISEASES inferred ¹² GeneCards inferred via : Summaries (show sections)
13	SLC6A4	Solute Carrier Family 6 Member 4	23.98	DISEASES inferred ¹² Novoseek inferred ⁴⁷ GeneCards inferred via : Publications (show sections)	10369890
14	EIF4E	Eukaryotic Translation Initiation Factor 4E	23.55	DISEASES inferred ¹² GeneCards inferred via : Publications (show sections)
15	DICER1	Dicer 1, Ribonuclease III	23.54	DISEASES inferred ¹² GeneCards inferred via : Publications (show sections)
16	BDNF	Brain-Derived Neurotrophic Factor	23.49	DISEASES inferred ¹² GeneCards inferred via : Publications (show sections)
17	FRAXE	Fragile Site, Folic Acid Type, Rare, Fra(X)(Q28) E	16.92	Novoseek inferred ⁴⁷ GeneCards inferred via : Publications (show sections)	11462240, 9415473, 14526173
18	MAP1B	Microtubule Associated Protein 1B	14.21	DISEASES inferred ¹² Novoseek inferred ⁴⁷	12927206
19	CGGBP1	CGG Triplet Repeat Binding Protein 1	14.14	DISEASES inferred ¹² GeneCards inferred via : Publications (show sections)
20	CYFIP2	Cytoplasmic FMR1 Interacting Protein 2	13.78	DISEASES inferred ¹² GeneCards inferred via : Publications (show sections)
21	TDRD3	Tudor Domain Containing 3	13.35	DISEASES inferred ¹² GeneCards inferred via : Publications (show sections)
22	MTOR	Mechanistic Target Of Rapamycin	13.16	DISEASES inferred ¹² GeneCards inferred via : Publications (show sections)
23	NOVA2	Neuro-Oncological Ventral Antigen 2	12.81	DISEASES inferred ¹² GeneCards inferred via : Publications (show sections)
24	HNRNPK	Heterogeneous Nuclear Ribonucleoprotein K	12.72	DISEASES inferred ¹² GeneCards inferred via : Publications (show sections)
25	FXN	Frataxin	12.34	DISEASES inferred ¹² GeneCards inferred via : Publications (show sections)
26	MMP9	Matrix Metallopeptidase 9	12.24	DISEASES inferred ¹² GeneCards inferred via : Publications (show sections)
27	PPP2R4	Protein Phosphatase 2A Regulatory Subunit 4	12.02	DISEASES inferred ¹² GeneCards inferred via : Publications (show sections)
28	HIST4H4	Histone Cluster 4, H4	11.96	DISEASES inferred ¹² GeneCards inferred via : Publications (show sections)
29	NR1H4	Nuclear Receptor Subfamily 1 Group H Member 4	11.81	DISEASES inferred ¹² Novoseek inferred ⁴⁷	8668200
30	AKT1	V-Akt Murine Thymoma Viral Oncogene Homolog 1	11.45	DISEASES inferred ¹² GeneCards inferred via : Publications (show sections)
31	HPRT1	Hypoxanthine Phosphoribosyltransferase 1	11.31	DISEASES inferred ¹² GeneCards inferred via : Publications (show sections)
32	FMR1-AS1	FMR1 Antisense RNA 1	8.55	GeneCards inferred via : Publications (show sections)
33	HTT	Huntingtin	8.43	DISEASES inferred ¹² Novoseek inferred ⁴⁷	7774118

Variations for Fragile X Syndrome

Sources:
⁶⁷UniProtKB/Swiss-Prot, ⁵Clinvar
See all MalaCards sources

UniProtKB/Swiss-Prot genetic disease variations for Fragile X Syndrome:

⁶⁷

id	Symbol	AA change	Variation ID	SNP ID
1	FMR1	p.Ile304Asn	VAR_005234

Clinvar genetic disease variations for Fragile X Syndrome:

⁵

id	Gene	Variation	Type	Significance	SNP ID	Assembly	Location
1		NM_002024.5(FMR1): c.-128_-126(200)	NT expansion	Pathogenic		GRCh38	Chr X, 147912052: 147912054
2	FMR1	NC_000023.9: g.146703942_146820448del	deletion	Pathogenic		NCBI36	Chr X, 146703942: 146820448
3	FMR1	FMR1, SER27TER	single nucleotide variant	Pathogenic
4	FMR1	NM_002024.5(FMR1): c.911T> A (p.Ile304Asn)	single nucleotide variant	Pathogenic	rs121434622	GRCh37	Chr X, 147018053: 147018053
5	FMR1	FMR1, 1-BP DEL, 373A	deletion	Pathogenic
6	FMR1	FMR1, IVS2AS1, G-T, -1 AND G-A, +1	single nucleotide variant	Pathogenic
7	FMR1	FMR1, (CGG)n EXPANSION	NT expansion	Pathogenic

Expression for genes affiliated with Fragile X Syndrome

Sources:
¹⁷Gene Expression Omnibus DataSets
See all MalaCards sources

Search GEO for disease gene expression data for Fragile X Syndrome.

Pathways for genes affiliated with Fragile X Syndrome

Sources:
⁵²PathCards, ³⁹NCBI BioSystems Database, ³¹KEGG
See all MalaCards sources

Pathways related to Fragile X Syndrome according to GeneCards Suite gene sharing:

id	Super pathways	Score	Top Affiliating Genes
1	GPCRs, Class C Metabotropic glutamate, pheromone³⁹	10.2	GRM1, GRM5
2	Hypothetical Network for Drug Addiction³⁹	10.0	GRIA1, GRM1, GRM5
3	BDNF signaling pathway³⁹	9.8	BDNF, CYFIP1, EIF4E, GRIA1
4	RNA transport³¹	9.4	CYFIP1, CYFIP2, EIF4E, FMR1, FRAXA, FXR1

GO Terms for genes affiliated with Fragile X Syndrome

Sources:
¹⁸Gene Ontology
See all MalaCards sources

Cellular components related to Fragile X Syndrome according to GeneCards Suite gene sharing:

id	Name	GO ID	Score	Top Affiliating Genes
1	neuron projection	GO:0043005	9.7	CYFIP1, FMR1, GRIA1, GRM1, GRM5, SLC6A4
2	postsynaptic density	GO:0014069	9.7	GRIA1, GRM1, GRM5
3	dendrite	GO:0030425	9.7	DICER1, FMR1, FXR1, GRIA1, GRM1

Biological processes related to Fragile X Syndrome according to GeneCards Suite gene sharing:

id	Name	GO ID	Score	Top Affiliating Genes
1	behavioral fear response	GO:0001662	10.1	EIF4E, MECP2
2	regulation of synaptic transmission, glutamatergic	GO:0051966	10.1	GRM1, GRM5

Molecular functions related to Fragile X Syndrome according to GeneCards Suite gene sharing:

id	Name	GO ID	Score	Top Affiliating Genes
1	mRNA 3-UTR binding	GO:0003730	10.4	FMR1, FXR1
2	protein heterodimerization activity	GO:0046982	10.3	FMR1, FXR1
3	siRNA binding	GO:0035197	10.0	DICER1, FMR1, MECP2
4	RNA binding	GO:0003723	9.6	DICER1, FMR1, FXR1, FXR2