Fragile X Syndrome malady

MedlinePlus: Fragile x syndrome is the most common form of inherited mental retardation. a problem with a specific gene causes the disease. normally, the gene makes a protein you need for brain development. but the mutation causes a person to make little or none of the protein, which results in the symptoms of fragile x. people with only a small change in the gene might not show any signs of fragile x. people with bigger changes can have severe symptoms. these might include intelligence problems, ranging from learning disabilities to severe mental retardation social and emotional problems, such as aggression in boys or shyness in girls speech and language problems, especially in boys fragile x has no cure. you can treat some symptoms with educational, behavioral or physical therapy, and with medicines. getting treatment early for fragile x can help. nih: national institute of child health and human development²³

MalaCards: Fragile X Syndrome, also known as fraxa syndrome, is related to mental retardation syndrome and mental retardation, x-linked. An important gene associated with Fragile X Syndrome is FMR1 (fragile X mental retardation 1), and among its related pathways are Glutamic acid signaling and Neuroscience. The compounds hydrofluoric acid and picrotoxin have been mentioned in the context of this disorder. Affiliated tissues include whole blood, brain and t cells, and related mouse phenotypes are no phenotypic analysis and endocrine/exocrine gland.

NIH Rare Diseases: Fragile X syndrome is a genetic condition involving changes in part of the X chromosome. This condition causes a range of developmental problems including learning disabilities and cognitive impairment. It is the most common form of inherited intellectual disability in males and a significant cause of intellectual disability in females.  Fragile X syndrome is caused by a change in the FMR1 gene. Fragile X syndrome is inherited in an X-linked dominant pattern.³⁰

Genetics Home Reference: Fragile X syndrome is a genetic condition that causes a range of developmental problems including learning disabilities and cognitive impairment. Usually, males are more severely affected by this disorder than females.¹⁷

Wikipedia: Fragile X syndrome (FXS), Martin–Bell syndrome, or Escalante\'s syndrome (more commonly called in...⁴⁴ more...

OMIM: 300624

Aliases & Descriptions:

fragile x syndrome 6 7 44 30 16 17 8 33 32 23 43 fraxa syndrome 44 30 16 17 32 43 martin-bell syndrome 6 44 30 16 17 marker x syndrome 6 44 30 16 17 fxs 44 30 16 17 x-linked mental retardation and macroorchidism 44 30 17

fra(x) syndrome 44 30 17 fragile x mental retardation syndrome 6 16 x-linked mental retardation and macro-orchidism 30 mental retardation, x-linked 43

Disease types for fragile x syndrome family:

fragile x syndrome type 1	fragile x syndrome type 2
fragile x syndrome type 3	fragile xe syndrome

Diseases related to fragile x syndrome by text searches and GeneDecks gene sharing:

(show top 50)    (show all 211)

id	Related Disease	Score	Top Affiliating Genes
1	mental retardation syndrome	34.7	FXR1, FXR2, FMR1, MECP2, NRF1, HELLS
2	mental retardation, x-linked	33.4	FTSJ1, FRAXE, MECP2, DLG3, TSPAN7, AFF2
3	mental retardation, x-linked, fraxe type	32.4	FRAXE, AFF2
4	premature ovarian failure	31.8	FRAXA, FRAXE, FMR1, GNRH1, AFF2
5	fragile x-associated tremor/ataxia syndrome	31.4	FRAXA, FMR1
6	ppm-x syndrome	31.3	BDNF, GRM1, MAOA, SLC6A4
7	developmental disabilities	29.0	BDNF, FMR1, MECP2, MAOA, HPRT1
8	huntington's disease	28.5	BDNF, ATN1, HTT, AKT1, EIF2AK2
9	myotonic dystrophy	28.2	FMR1, HTT, AKT1, PPP1R12A, EIF2AK2, SIX5
10	ataxia	26.2	ATN1, FXR2, FRAXA, FMR1, MECP2, GRM1
11	colorectal cancer	20.5	BDNF, FXR1, MECP2, GRM1, MAOA, MAPK1
12	neuronitis	18.1	RABEP2, PAH, BDNF, KCNF1, KCNG1, ATN1
13	fragile xe syndrome	13.7	FMR1, AFF2
14	pervasive developmental disorder	13.6	FRAXA, FRAXE, MECP2, TMEM185A, SLC6A4
15	autistic disorder	13.5	BDNF, FMR1, MECP2, SLC6A4
16	bipolar disorder	13.3	BDNF, SLC6A4
17	multiple system atrophy	13.3	BDNF, ATN1, FRAXA, FMR1, MAP1B, HTT
18	neurotic disorder	13.3	BDNF, MAOA, SLC6A4
19	postpartum depression	13.3	BDNF, MAOA, SLC6A4
20	retrograde amnesia	13.2	RABEP2, MAPK1, SLC6A4
21	attention deficit hyperactivity disorder	13.2	BDNF, FMR1, MAOA, SLC6A4
22	anxiety disorder	13.2	BDNF, FMR1, MAOA, SLC6A4
23	heroin dependence	13.2	BDNF, MAOA, SLC6A4, GABRA1
24	borderline personality disorder	13.2	BDNF, MAOA, SLC6A4
25	growth mental deficiency syndrome of myhre	13.2	BDNF, MECP2, MAOA, TMEM185A, SLC6A4
26	x inactivation	13.0	FMR1, MECP2, HPRT1, HIST4H4, SLC6A8
27	bulimia nervosa	13.0	BDNF, MAOA, ST14, SLC6A4
28	drug addiction	13.0	BDNF, GRM5, MAPK1
29	schizoaffective disorder	12.9	BDNF, MAOA, SLC6A4, GABRA1
30	olivopontocerebellar atrophy	12.9	ATN1, FRAXA, FMR1, HTT, AKT1, AFF2
31	autism spectrum disorder	12.9	BDNF, MECP2, MAOA, DLG3, TSPAN7, SLC6A8
32	substance dependence	12.9	BDNF, GRIA1, GRIK1, MAOA, SLC6A4
33	was-related disorders	12.7	BDNF, FMR1, MECP2, GNRH1, NR1H4, WRN
34	status epilepticus	12.7	BDNF, ATN1, GRIA1, GRM5
35	mood disorder	12.7	BDNF, MAOA, SLC6A4, GABRA1
36	tardive dyskinesia	12.6	PAH, BDNF, MAOA, AKT1, SLC6A4
37	alcohol dependence	12.6	BDNF, GRIK1, GRM5, MAOA, SLC6A4, GABRA1
38	temporal lobe epilepsy	12.5	BDNF, GRIK1, GRM1, GRM5
39	central nervous system disease	12.5	BDNF, GRM1, GRM5, HPRT1, SLC6A4
40	mayer-rokitansky-kuster-hauser syndrome	12.4	PAH, FRAXA, FMR1, MECP2, HTT, HPRT1
41	bloom syndrome	12.4	HPRT1, EIF4E, HELLS, WRN
42	major depressive disorder	12.3	BDNF, GRIK1, MAOA, HTT, AKT1, SLC6A4
43	tuberous sclerosis	12.3	PAH, MECP2, MAPK1, MAP1B, AKT1, EIF4E
44	down syndrome	12.3	RABEP2, BDNF, FMR1, MECP2, GRIK1, GRM5
45	intractable epilepsy	12.2	BDNF, GRM1, GRM5, MAPK1, SLC6A8
46	anorexia nervosa	12.1	PAH, BDNF, GRIA1, GRM5, MAOA, MAPK1
47	twinning	12.1	BDNF, ATN1, FRAXE, FMR1, MECP2, MAOA
48	pick's disease	12.0	BDNF, GRM1, MAOA, MAPK1, HTT
49	albinism	11.9	GRIA1, GRM1, GRM5, HTT, HPRT1, TYMS
50	brain injury	11.8	RABEP2, BDNF, GRIK1, MAOA, MAPK1, AKT1

Clinical features from OMIM: 300624

Approved drugs:

Drug clinical trials:

Genetic tests related to fragile x syndrome:

id	Genetic test	Affiliating Genes
1	Fragile X Syndrome clinical/research	FMR1, FRAXA

MalaCards organs/tissues related to fragile x syndrome:

²²

MGI Mouse Phenotypes related to fragile x syndrome:

²⁵

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	no phenotypic analysis	MP:0003012	8.5	SLC6A8, EIF2C1, NR1H4, DICER1, HPRT1, HTT
2	endocrine/exocrine gland phenotype	MP:0005379	7.6	AKT1, DICER1, ST14, SLC6A4, SIX5, WRN
3	normal phenotype	MP:0002873	7.0	HPRT1, AKT1, DICER1, EIF2C1, SLC6A4, WNT7A
4	integument phenotype	MP:0010771	6.7	AKT1, DLGAP3, DICER1, EIF2C1, HELLS, ST14
5	reproductive system phenotype	MP:0005389	6.1	HTT, GNRH1, HPRT1, AKT1, DICER1, SIX5
6	homeostasis/metabolism phenotype	MP:0005376	5.4	DICER1, NR1H4, HELLS, ST14, SLC6A8, SLC6A4
7	nervous system phenotype	MP:0003631	5.2	MAP1B, HTT, GNRH1, HPRT1, AKT1, DLG3
8	growth/size phenotype	MP:0005378	4.9	NR1H4, DICER1, AKT1, HPRT1, GNRH1, HELLS
9	mortality/aging	MP:0010768	4.8	NR1H4, NRF1, NOVA2, EIF2AK2, HELLS, ST14
10	behavior/neurological phenotype	MP:0005386	4.8	PAH, HTT, HPRT1, AKT1, DLG3, DLGAP3

Articles related to fragile x syndrome:

(show top 50)    (show all 206)

id	Title	Authors	Year	Affiliating Genes
1	Epigenetic modification of the FMR1 gene in fragile X syndrome is associated with differential response to the mGluR5 antagonist AFQ 056. (21209411)	Jacquemont S.... Gomez-Mancilla B.	2011	FMR1
2	Whole-brain expression analysis of FMRP in adult monk ey and its relationship to cognitive deficits in fragile X syndrome. (19368811)	Zangenehpour S.... Chaudhuri A.	2009	FMR1
3	Molecular analysis of Fragile X syndrome. (19806593)	Basehore M.J.... Friez M.J.	2009	FMR1
4	A mouse model of the human Fragile X syndrome I304N m utation. (20011099)	Zang J.B.... Darnell R.B.	2009	FMR1
5	Abnormal striatal GABA transmission in the mouse mode l for the fragile X syndrome. (18028882)	Centonze D.... Bagni C.	2008	FMR1
6	Analysis of the molecular parameters that could predict the risk of manifesting premature ovarian failure in female premutation carriers of fragile X syndrome. (18427356)	Tejada M.I.... Ramos F.	2008	FMR1
7	Aberrant early-phase ERK inactivation impedes neuronal function in fragile X syndrome. (18332424)	Kim S.H.... Greenough W.T.	2008	MAPK1, PPP2R4
8	Longitudinal changes in intellectual development in c hildren with Fragile X syndrome. (18347972)	Hall S.S.... Reiss A.L.	2008	FMR1
9	Age-dependent cognitive changes in carriers of the fragile X syndrome. (18472033)	Cornish K.M.... Hagerman P.J.	2008	FMR1
10	A novel polymorphism in the FMR1 gene: implications for clinical testing of fragile X syndrome. (18181681)	Thyagarajan B.... Wang X.	2008	FMR1
11	Whole genome microarray analysis of gene expression in subjects with fragile X syndrome. (17666893)	Bittel D.C.... Butler M.G.	2007	FMR1
12	Multiple Gq-coupled receptors converge on a common protein synthesis-dependent long-term depression that is affected in fragile X syndrome mental retardation. (17959805)	Volk L.J.... Huber K.M.	2007	FMR1
13	Presynaptic FMR1 genotype influences the degree of sy naptic connectivity in a mosaic mouse model of fragile X syndrome. (17428978)	Hanson J.E.... Madison D.V.	2007	FMR1
14	Deletion of FMR1 in Purkinje cells enhances parallel fiber LTD, enlarges spines, and attenuates cerebellar eyelid conditioning in Fragile X syndrome. (16055059)	Koekkoek S.K.... De Zeeuw C.I.	2005	FMR1
15	Fragile X syndrome carrier screening in the prenatal genetic counseling setting. (15834242)	Cronister A.... Hallam S.	2005	FRAXA
16	Fragile X syndrome. (16010677)	Terracciano A.... Neri G.	2005	FRAXA
17	Video analysis of sensory-motor features in infants with fragile X syndrome at 9-12 months of age. (16172809)	Baranek G.T.... Mirrett P.L.	2005	FMR1
18	Five years of molecular diagnosis of Fragile X syndrome (1997-2001): a collaborative study reporting 95% of the activity in France. (15326620)	Biancalana V.... Mandel J.L.	2004	FRAXA
19	Frontostriatal deficits in fragile X syndrome: relation to FMR1 gene expression. (14993603)	Menon V.... Reiss A.L.	2004	FMR1
20	A step-wise diagnosis of fragile X syndrome in Taiwan. (15335113)	Huang Y.T.... Hwu W.L.	2004	FRAXA
21	Fragile X syndrome: a clinico-genetic study of mentally retarded patients in Kuwait. (16201716)	Bastaki L.A.... Naguib K.K.	2004	FRAXE, FRAXA
22	Autistic-like behaviour profile and psychiatric morbidity in Fragile X Syndrome: a prospective ten-year follow-up study. (14505067)	Sabaratnam M.... Payne S.	2003	FRAXA
23	FMRP immunodetection on hair roots: application to t he diagnosis of fragile X syndrome (14588214)	RifAc Soler M.... Mila Recasens M.	2003	FMR1
24	Premutation and intermediate-size FMR1 alleles in 10572 males from the general population: loss of an AGG interruption is a late event in the generation of fragile X syndrome alleles. (11854169)	Dombrowski C.... Rousseau F.	2002	FMR1
25	Epilepsy in fragile X syndrome. (12418611)	Berry-Kravis E.	2002	FMR1
26	Molecular pathogenesis of fragile X syndrome (12810982)	Sielska D.... Bal J.	2002	FMR1
27	Alterations in the auditory startle response in Fmr1 targeted mutant mouse models of fragile X syndrome. (11814427)	Nielsen D.M.... Crnic L.S.	2002	FMR1
28	Fragile X syndrome in Calcutta, India. (11392502)	Saha S.... Dasgupta U.B.	2001	FRAXA
29	An assessment of screening strategies for fragile X syndrome in the UK. (11262423)	Pembrey M.E.... Turner G.	2001	FMR1
30	Detection of the fragile X syndrome protein for the evaluation of FMR1 intermediate alleles. (11030419)	CastellvA--Bel S.... Mila M.	2000	FMR1
31	Molecular mechanisms of fragile X syndrome. (11019488)	Inoue S.B.... Siomi H.	2000	FMR1
32	Dissecting FMR1, the protein responsible for fragile X syndrome, in its structural and functional domains. (10496225)	Adinolfi S.... Pastore A.	1999	FMR1
33	Acetylated histones are associated with FMR1 in normal but not fragile X-syndrome cells. (10319871)	Coffee B.... Reines D.	1999	FMR1, MECP2, HIST4H4
34	Noninvasive test for fragile X syndrome, using hair root analysis. (10364521)	Willemsen R.... Oostra B.A.	1999	FMR1
35	FMRP expression as a potential prognostic indicator in fragile X syndrome. (10331602)	Tassone F.... Taylor A.K.	1999	FMR1
36	Point mutation in intron 10 of FMR1 is unlikely to be a cause of fragile X syndrome. (9829913)	Vincent J.B.... Gurling H.M.	1998	FMR1
37	FMRP associates with polyribosomes as an mRNP, and the I304N mutation of severe fragile X syndrome abolishes this association. (9659908)	Feng Y.... Warren S.T.	1997	FMR1
38	The fragile X syndrome. (9211186)	Hoogeveen A.T.... Oostra B.A.	1997	FMR1
39	Novel point mutation within intron 10 of FMR-1 gene causing fragile X syndrome. (9375856)	Wang Y.-C.... Li S.-Y.	1997	FMR1
40	Fragile X syndrome and deletions in FMR1: new case and review of the literature. (9375726)	Hammond L.S.... Shashidhar Pai G.	1997	FMR1
41	A genetic and molecular study of 85 families affected with the fragile X syndrome (8830601)	Mila Recasens M.... Estivill Palleja X.	1996	FRAXA
42	Intragenic loss of function mutations demonstrate the primary role of FMR1 in fragile X syndrome. (7670500)	Lugenbeel K.A.... Nelson D.L.	1995	FMR1
43	Rett-like syndrome in fragile X syndrome. (8588847)	Alembik Y.... Stoll C.	1995	FRAXA
44	Prenatal diagnosis of fragile X syndrome: (CGG)n expansion and methylation of chorionic villus samples. (8559749)	CastellvA--Bel S.... Estivill X.	1995	FMR1
45	Essential role for KH domains in RNA binding: impaired RNA binding by a mutation in the KH domain of FMR1 that causes fragile X syndrome. (8156595)	Siomi H.... Dreyfuss G.	1994	FMR1, HNRNPK
46	Genotype-phenotype relationships in fragile X syndrome: a family study. (8213832)	Loesch D.Z.... Sutherland G.R.	1993	FMR1
47	Characterization and localization of the FMR-1 gene product associated with fragile X syndrome. (8515814)	Verheij C.... Oostra B.A.	1993	FMR1
48	High resolution methylation analysis of the FMR1 gene trinucleotide repeat region in fragile X syndrome. (8268919)	Hornstra I.K.... Yang T.P.	1993	FMR1, CGGBP1
49	Association of fragile X syndrome with delayed replication of the FMR1 gene. (8324827)	Hansen R.S.... Laird C.D.	1993	FMR1
50	Fragile X syndrome without CCG amplification has an FMR1 deletion. (1302032)	Gedeon A.K.... Sutherland G.R.	1992	FMR1

Genes related to fragile x syndrome according to GeneCards:

(show top 50)    (show all 59)

id	Symbol	Description	Score	GeneCards Section Context
1	FMR1	fragile X mental retardation 1	11.1	Summaries, Publications
2	FRAXA	fragile site, folic acid type, rare, fra(X)(q27.3) A (macroorchidism, mental retardation)	11.0	Publications
3	FRAXE	fragile site, folic acid type, rare, fra(X)(q28) E	11.0	Publications
4	FXR2	fragile X mental retardation, autosomal homolog 2	11.0	Publications
5	FXR1	fragile X mental retardation, autosomal homolog 1	11.0	Publications
6	CYFIP1	cytoplasmic FMR1 interacting protein 1	11.0	Publications
7	NR1H4	nuclear receptor subfamily 1, group H, member 4	11.0	Publications
8	PAH	phenylalanine hydroxylase	11.0
9	AFF2	AF4/FMR2 family, member 2	11.0	Publications
10	MECP2	methyl CpG binding protein 2 (Rett syndrome)	11.0	Publications
11	HTT	huntingtin	11.0	Publications
12	MAP1B	microtubule-associated protein 1B	11.0
13	SLC6A4	solute carrier family 6 (neurotransmitter transporter, serotonin), member 4	11.0	Publications
14	GRM5	glutamate receptor, metabotropic 5	11.0	Publications
15	TSPAN7	tetraspanin 7	11.0	Summaries
16	FMR1-AS1	FMR1 antisense RNA 1	11.0	Publications
17	SIX5	SIX homeobox 5	11.0	Publications
18	RABEP2	rabaptin, RAB GTPase binding effector protein 2	11.0	Publications
19	KCNF1	potassium voltage-gated channel, subfamily F, member 1	11.0
20	NOVA2	neuro-oncological ventral antigen 2	11.0	Publications
21	MTFMT	mitochondrial methionyl-tRNA formyltransferase	11.0	Disorders
22	NFYB	nuclear transcription factor Y, beta	11.0
23	CGGBP1	CGG triplet repeat binding protein 1	11.0	Publications
24	KCNG1	potassium voltage-gated channel, subfamily G, member 1	11.0
25	LEO1	Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)	11.0	Publications
26	NUFIP2	nuclear fragile X mental retardation protein interacting protein 2	11.0
27	SLC6A8	solute carrier family 6 (neurotransmitter transporter, creatine), member 8	11.0
28	DLGAP3	discs, large (Drosophila) homolog-associated protein 3	11.0
29	FTSJ1	FtsJ RNA methyltransferase homolog 1 (E. coli)	11.0
30	TMEM185A	transmembrane protein 185A	11.0
31	FHL1	four and a half LIM domains 1	11.0	Functions
32	GABRA1	gamma-aminobutyric acid (GABA) A receptor, alpha 1	11.0	Publications
33	WNT7A	wingless-type MMTV integration site family, member 7A	11.0	Publications
34	EIF2C1	eukaryotic translation initiation factor 2C, 1	11.0
35	ATN1	atrophin 1	11.0
36	GTPBP1	GTP binding protein 1	11.0
37	HNRNPK	heterogeneous nuclear ribonucleoprotein K	11.0	Publications
38	DICER1	dicer 1, ribonuclease type III	11.0	Publications
39	ST14	suppression of tumorigenicity 14 (colon carcinoma)	11.0
40	TDRD3	tudor domain containing 3	11.0	Disorders, Publications
41	DLG3	discs, large homolog 3 (Drosophila)	11.0
42	WRN	Werner syndrome, RecQ helicase-like	11.0	Publications
43	TYMS	thymidylate synthetase	11.0	Publications
44	NRF1	nuclear respiratory factor 1	11.0
45	PPP2R4	protein phosphatase 2A activator, regulatory subunit 4	11.0	Publications
46	PPP1R12A	protein phosphatase 1, regulatory subunit 12A	11.0
47	GRIA1	glutamate receptor, ionotropic, AMPA 1	11.0	Publications
48	GRIK1	glutamate receptor, ionotropic, kainate 1	11.0
49	BDNF	brain-derived neurotrophic factor	11.0	Publications
50	GNRH1	gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)	11.0	Publications

Pathways related to fragile x syndrome according to GeneDecks:

(show all 11)

id	Pathway	Score	Top Affiliating Genes
1	Glutamic acid signaling10	9.5	GRIA1, GRIK1, GRM1, GRM5
2	Neuroscience3	9.5	DLG3, HTT, GRM1, GRIA1, MECP2, FMR1
3	Translational Control3	9.4	FXR1, EIF4E, EIF2C1, EIF2AK2, DICER1, HNRNPK
4	Long-term depression20	8.8	GRIA1, GRM1, GRM5, MAPK1
5	Long-term potentiation20	8.7	PPP1R12A, MAPK1, GRM5, GRM1, GRIA1
6	Neuropathic Pain-Signaling in Dorsal Horn Neurons36	8.4	MAPK1, GRM5, GRM1, GRIA1, BDNF
7	Glutamatergic synapse20	8.2	MAPK1, GRM5, GRM1, GRIK1, GRIA1
8	mTOR Pathway36	8.0	EIF4E, PPP2R4, AKT1, GNRH1, MAPK1, BDNF
9	GSK3 Signaling36	7.9	WNT7A, EIF2C1, PPP2R4, AKT1, GNRH1, MAPK1
10	eIF2 Pathway36	7.9	EIF4E, EIF2C1, PPP1R12A, AKT1, GNRH1, MAPK1
11	CREB Pathway36	7.5	AKT1, GNRH1, MAPK1, GRM5, GRM1, GRIK1

Compounds related to fragile x syndrome according to GeneDecks:

(show top 50)    (show all 56)

id	Compound	Score	Top Affiliating Genes
1	hydrofluoric acid32	10.6	SLC6A4, GRM5
2	picrotoxin32 9 9	12.3	GABRA1, GRIA1, LEO1
3	chpg32	10.2	GRM5, GRM1
4	lithium32 34 9 18 9	14.2	SLC6A4, PPP2R4, MAP1B, FMR1, BDNF
5	2-methyl-6-(phenylethynyl)pyridine32	10.2	GRM5, GRM1
6	hpaii32	10.2	HPRT1, MECP2, FMR1
7	ly36738532	10.1	GRM5, GRM1
8	bicuculline32	10.1	GNRH1, LEO1, BDNF
9	cyclothiazide32 9 9	12.1	GRIK1, GRIA1, BDNF
10	folate32	9.9	PAH, FMR1, MECP2, HPRT1, TYMS, AFF2
11	maoa32	9.9	SLC6A4, MAOA, BDNF
12	pentobarbital32 9 9	11.9	GABRA1, GRIA1, LEO1
13	quisqualate32 9 9	11.8	GRM5, GRM1, BDNF
14	mhpg32	9.8	SLC6A4, GNRH1, MAOA, BDNF
15	cocaine32 9 9	11.8	SLC6A4, GNRH1, GRM5, GRIA1, BDNF, RABEP2
16	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid32	9.8	GRM5, GRM1, GRIA1, BDNF
17	homovanillic acid32 18	10.7	SLC6A4, MAOA, BDNF
18	fluvoxamine32 34 9 9	12.7	BDNF, MAOA, SLC6A4
19	alanine32	9.6	SLC6A4, HELLS, EIF4E, PPP2R4, HTT, MECP2
20	1 methyl 4 phenylpyridinium32	9.4	SLC6A4, MAOA, BDNF
21	nocodazole32 42 9 9	12.3	PPP1R12A, PPP2R4, AKT1, MAP1B, BDNF
22	nitric oxide32 9 18 9	12.2	ST14, EIF4E, EIF2AK2, NRF1, PPP1R12A, GRM5
23	valine32	9.1	SLC6A4, TYMS, AKT1, HPRT1, BDNF, PAH
24	glycogen32 18	10.1	WNT7A, EIF4E, PPP2R4, AKT1, HTT, MAP1B
25	oligonucleotide32	9.0	HELLS, EIF4E, EIF2AK2, PPP2R4, HTT, MAP1B
26	aicar32 42 9 18 9	13.0	TYMS, NRF1, AKT1, MAPK1
27	epinephrine32 9 18 9	11.8	SLC6A4, EIF4E, AKT1, GNRH1, MAOA, BDNF
28	okadaic acid32 42	9.8	EIF4E, EIF2AK2, PPP1R12A, PPP2R4, MAPK1, GRM5
29	creatinine32	8.8	SLC6A8, TYMS, AKT1, HPRT1, HTT, FMR1
30	gnrh32	8.5	SLC6A4, PPP2R4, AKT1, GNRH1, MAPK1, BDNF
31	kainate32	8.4	HIST4H4, DLG3, GNRH1, HTT, GRM5, GRM1
32	rapamycin32 42	9.4	EIF4E, PPP2R4, AKT1, HTT, MAPK1, FMR1
33	aspartate32	8.2	SLC6A4, EIF2AK2, AKT1, GNRH1, GRM5, GRM1
34	glutamine32	8.1	HIST4H4, HELLS, PPP2R4, AKT1, HPRT1, HTT
35	cysteine32	8.1	WRN, TYMS, HIST4H4, HELLS, EIF4E, PPP2R4
36	testosterone32 9 18 9	11.1	HPRT1, AKT1, PPP2R4, NR1H4, SLC6A4, GNRH1
37	gaba32 42	9.0	BDNF, GABRA1, SLC6A4, PPP2R4, GNRH1, MAP1B
38	thapsigargin32 42	8.8	EIF2AK2, PPP2R4, AKT1, GNRH1, MAPK1, GRM1
39	threonine32	7.5	HELLS, EIF4E, EIF2AK2, PPP2R4, AKT1, MAP1B
40	dopamine32 9 18 9	10.2	HTT, GNRH1, HPRT1, AKT1, PPP2R4, SLC6A4
41	adenylate32	7.1	HPRT1, AKT1, EIF4E, HIST4H4, TYMS, WRN
42	cisplatin32 34 9 9	10.1	EIF4E, HELLS, TYMS, WRN, PPP2R4, AKT1
43	nmda32 42	8.0	HTT, AKT1, DLG3, PPP2R4, SLC6A4, MAP1B
44	estrogen32	7.0	WNT7A, SLC6A4, HIST4H4, EIF4E, NR1H4, PPP2R4
45	arginine32	6.9	EIF2AK2, HELLS, HIST4H4, TYMS, SLC6A8, SLC6A4
46	retinoic acid32 42 18	8.7	HIST4H4, HELLS, EIF4E, EIF2AK2, NR1H4, PPP2R4
47	h2o232	6.5	WRN, SLC6A4, HIST4H4, HELLS, EIF4E, PPP2R4
48	serine32	6.5	PPP2R4, EIF2AK2, EIF4E, HELLS, TYMS, ST14
49	tyrosine32	5.7	HNRNPK, DLG3, PPP2R4, NR1H4, EIF2AK2, EIF4E
50	glutamate32	5.3	HPRT1, AKT1, DLG3, PPP2R4, EIF2AK2, EIF4E

Cellular components related to fragile x syndrome according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	mRNA cap binding complex	GO:005845	9.7	FMR1, CYFIP1, EIF4E
2	cell junction	GO:030054	9.4	CYFIP1, DLGAP3, MAP1B, GRIK1, GRIA1, ATN1

Biological processes related to fragile x syndrome according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of synapse assembly	GO:051965	10.0	BDNF, MECP2, WNT7A
2	synaptic transmission	GO:007268	7.3	KCNF1, GABRA1, DLG3, MAPK1, MAOA, GRM5

Molecular functions related to fragile x syndrome according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	glutamate receptor activity	GO:008066	9.3	GRIA1, GRM1, GRM5
2	protein binding	GO:005515	5.2	DLGAP3, DICER1, CYFIP1, PPP1R12A, NR1H4, NFYB