FRASS
MCID: FRS003
MIFTS: 56

Fraser Syndrome (FRASS) malady

Categories: Genetic diseases, Rare diseases

Aliases & Classifications for Fraser Syndrome

Aliases & Descriptions for Fraser Syndrome:

Name: Fraser Syndrome 54 50 25 66 13 52
Cryptophthalmos Syndrome 50 25 29 69
Cryptophthalmos with Other Malformations 50 25
Fraser-Francois Syndrome 50 25
Cryptophthalmos-Syndactyly Syndrome 50
Cryptophthalmos Syndactyly Syndrome 25
Meyer-Schwickerath's Syndrome 50
Meyer-Schwickerath Syndrome 25
Ullrich-Feichtiger Syndrome 25
Ulrich-Feichtiger Syndrome 50
Fraser's Syndrome 25
Cyclopism 50
Frass 66

Characteristics:

HPO:

32
fraser syndrome:
Mortality/Aging death in infancy
Inheritance autosomal recessive inheritance


Classifications:



External Ids:

OMIM 54 219000
MedGen 40 C0265233

Summaries for Fraser Syndrome

NIH Rare Diseases : 50 fraser syndrome is a rare genetic disorder characterized by fused eyelids (cryptophthalmos), fusion of the skin between the fingers and toes (syndactyly), and abnormalities of the genitalia and urinary tract. signs and symptoms occur early in development and may also include abnormalities of the respiratory tract, specifically involving the larynx (voice box) and trachea (windpipe); failure of kidney development affecting one or both kidneys (renal agenesis); umbilical hernia; abnormalities of the nose and ear; cleft lip and palate; skeletal abnormalities; and intellectual disability. depending on the severity of the signs and symptoms, fraser syndrome can be fatal before or shortly after birth. less severely affected individuals can live into childhood or adulthood.  fraser syndrome is caused by mutations in three different genes: fras1, grip1, and frem2 and is inherited in an autosomal recessive manner. this condition is diagnosed based on signs and symptoms. genetic testing may be useful to confirm the diagnosis. while there is no cure for fraser syndrome, there may be ways to manage symptoms, depending on the severity. a team of doctors is often needed to figure out the treatment options for each person.  last updated: 12/7/2016

MalaCards based summary : Fraser Syndrome, also known as cryptophthalmos syndrome, is related to sanderson fraser syndrome and fras1-related fraser syndrome, and has symptoms including hypertelorism, low-set ears and finger syndactyly. An important gene associated with Fraser Syndrome is FREM2 (FRAS1 Related Extracellular Matrix Protein 2), and among its related pathways/superpathways are Elastic fibre formation and ECM proteoglycans. The drugs Verapamil and Perindopril have been mentioned in the context of this disorder. Affiliated tissues include skin, kidney and heart, and related phenotypes are growth/size/body region and mortality/aging

Genetics Home Reference : 25 Fraser syndrome is a rare disorder that affects development starting before birth. Characteristic features of this condition include eyes that are completely covered by skin and usually malformed (cryptophthalmos), fusion of the skin between the fingers and toes (cutaneous syndactyly), and abnormalities of the genitalia and the urinary tract (genitourinary anomalies). Other tissues and organs can also be affected. Depending on the severity of the signs and symptoms, Fraser syndrome can be fatal before or shortly after birth; less severely affected individuals can live into childhood or adulthood.

OMIM : 54 Fraser syndrome is a rare autosomal recessive disorder characterized by cryptophthalmos, syndactyly, ambiguous... (219000) more...

UniProtKB/Swiss-Prot : 66 Fraser syndrome: Multisystem malformation usually comprising cryptophthalmos, cutaneous syndactyly, ear abnormalities, renal agenesis and congenital heart defects.

Wikipedia : 71 Fraser syndrome (also known as Meyer-Schwickerath\'s syndrome, Fraser-François syndrome, or... more...

Related Diseases for Fraser Syndrome

Graphical network of the top 20 diseases related to Fraser Syndrome:



Diseases related to Fraser Syndrome

Symptoms & Phenotypes for Fraser Syndrome

Symptoms by clinical synopsis from OMIM:

219000

Clinical features from OMIM:

219000

Human phenotypes related to Fraser Syndrome:

32 (show top 50) (show all 87)
id Description HPO Frequency HPO Source Accession
1 hypertelorism 32 HP:0000316
2 low-set ears 32 HP:0000369
3 finger syndactyly 32 HP:0006101
4 high palate 32 HP:0000218
5 hydrocephalus 32 HP:0000238
6 intellectual disability 32 HP:0001249
7 dental malocclusion 32 HP:0000689
8 depressed nasal bridge 32 HP:0005280
9 corneal opacity 32 HP:0007957
10 wide nasal bridge 32 HP:0000431
11 umbilical hernia 32 HP:0001537
12 microcephaly 32 HP:0000252
13 blindness 32 HP:0000618
14 cleft palate 32 HP:0000175
15 cryptorchidism 32 HP:0000028
16 wide intermamillary distance 32 HP:0006610
17 abnormality of the pinna 32 HP:0000377
18 underdeveloped nasal alae 32 HP:0000430
19 microphthalmia 32 HP:0000568
20 hypospadias 32 HP:0000047
21 multicystic kidney dysplasia 32 HP:0000003
22 low-set, posteriorly rotated ears 32 HP:0000368
23 renal hypoplasia/aplasia 32 HP:0008678
24 dental crowding 32 HP:0000678
25 conductive hearing impairment 32 HP:0000405
26 anal atresia 32 HP:0002023
27 renal hypoplasia 32 HP:0000089
28 hypoplasia of penis 32 HP:0008736
29 abnormal hair pattern 32 HP:0010720
30 tracheal stenosis 32 HP:0002777
31 vertebral segmentation defect 32 HP:0003422
32 female pseudohermaphroditism 32 HP:0010458
33 ambiguous genitalia 32 HP:0000062
34 cutaneous finger syndactyly 32 HP:0010554
35 toe syndactyly 32 HP:0001770
36 external ear malformation 32 HP:0008572
37 cleft upper lip 32 HP:0000204
38 atresia of the external auditory canal 32 HP:0000413
39 wide nose 32 HP:0000445
40 urethral atresia 32 HP:0000068
41 anophthalmia 32 HP:0000528
42 encephalocele 32 HP:0002084
43 omphalocele 32 HP:0001539
44 ectopic anus 32 HP:0004397
45 aplasia/hypoplasia of the thumb 32 HP:0009601
46 abnormality of cardiovascular system morphology 32 HP:0030680
47 scrotal hypoplasia 32 HP:0000046
48 absent eyelashes 32 HP:0000561
49 facial cleft 32 HP:0002006
50 abnormal lung lobation 32 HP:0002101

MGI Mouse Phenotypes related to Fraser Syndrome:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10 FRAS1 FREM1 FREM2 GREM1 GRIA2 GRIP1
2 mortality/aging MP:0010768 9.92 FRAS1 FREM1 FREM2 GREM1 GRIA2 GRIP1
3 integument MP:0010771 9.88 FRAS1 FREM1 FREM2 GRIA2 GRIP1 ITGB1
4 limbs/digits/tail MP:0005371 9.85 FREM1 FREM2 GREM1 GRIP1 ITGB1 FRAS1
5 nervous system MP:0003631 9.8 GRIP1 ITGA8 ITGB1 FREM1 FREM2 GREM1
6 hearing/vestibular/ear MP:0005377 9.73 FREM2 GRIA2 ITGA8 ITGB1
7 renal/urinary system MP:0005367 9.7 FRAS1 FREM1 FREM2 GREM1 GRIP1 ITGA8
8 respiratory system MP:0005388 9.43 FRAS1 FREM1 FREM2 GREM1 ITGA8 ITGB1
9 vision/eye MP:0005391 9.02 FRAS1 FREM1 FREM2 GRIP1 ITGB1

Drugs & Therapeutics for Fraser Syndrome

Drugs for Fraser Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 74)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Verapamil Approved Phase 4 52-53-9 2520
2
Perindopril Approved Phase 4 107133-36-8, 82834-16-0 107807
3
Atenolol Approved Phase 4 29122-68-7 2249
4
Tazobactam Approved Phase 4 89786-04-9 123630
5
Piperacillin Approved Phase 4 66258-76-2 43672
6 Neurotransmitter Agents Phase 4,Phase 3
7 Peripheral Nervous System Agents Phase 4,Phase 3
8 Autonomic Agents Phase 4,Phase 3
9 calcium channel blockers Phase 4
10
protease inhibitors Phase 4
11 Adrenergic Agents Phase 4
12 Adrenergic Antagonists Phase 4
13 Adrenergic beta-1 Receptor Antagonists Phase 4
14 Adrenergic beta-Antagonists Phase 4
15 Sympatholytics Phase 4
16 HIV Protease Inhibitors Phase 4
17 Dermatologic Agents Phase 4
18 Vasodilator Agents Phase 4
19 Emollients Phase 4
20 Angiotensin-Converting Enzyme Inhibitors Phase 4
21 Anti-Arrhythmia Agents Phase 4
22 Anti-Bacterial Agents Phase 4,Phase 3
23 Anti-Infective Agents Phase 4,Phase 3
24 Antihypertensive Agents Phase 4
25 Calcium, Dietary Phase 4
26 Penicillanic Acid Phase 4
27 Piperacillin, tazobactam drug combination Phase 4
28 beta-Lactamase Inhibitors Phase 4
29 Antibiotics, Antitubercular Phase 4
30
Dopamine Approved Phase 3 51-61-6, 62-31-7 681
31
Metoclopramide Approved, Investigational Phase 3 364-62-5 4168
32
Minocycline Approved, Investigational Phase 3 10118-90-8 5281021
33
Aspirin Approved, Vet_approved Phase 3 50-78-2 2244
34
Omeprazole Approved, Investigational, Vet_approved Phase 3 73590-58-6 4594
35
Ribavirin Approved Phase 3 36791-04-5 37542
36
Ticlopidine Approved Phase 3 55142-85-3 5472
37
Peginterferon alfa-2a Approved, Investigational Phase 3 198153-51-4 5360545
38
Clopidogrel Approved, Nutraceutical Phase 3 120202-66-6, 113665-84-2 60606
39 Senna Extract Phase 3
40 Sennoside A&B Phase 3
41 Gastrointestinal Agents Phase 3
42 Dopamine Agents Phase 3
43 Dopamine Antagonists Phase 3
44 Dopamine D2 Receptor Antagonists Phase 3
45 Antiemetics Phase 3
46 Laxatives Phase 3
47 Magnesium citrate Phase 3
48 Cathartics Phase 3
49 Carboxymethylcellulose Sodium Phase 3
50
Proton pump inhibitors Phase 3

Interventional clinical trials:

(show all 25)
id Name Status NCT ID Phase
1 Comparison of Medical Therapies in Marfan Syndrome. Completed NCT01295047 Phase 4
2 Promiseb Topical Cream for Cradle Cap Completed NCT01214434 Phase 4
3 Effect of Adaptive Servo Ventilation (ASV) on Survival and Hospital Admissions in Heart Failure Recruiting NCT01128816 Phase 4
4 Standard Vs Adjusted Dosing of Piperacillin/Tazobactam in Acute Renal Failure and Septic Shock Terminated NCT00816790 Phase 4
5 Bowel Preparation and Prokinetics in Capsule Endoscopy Unknown status NCT00275184 Phase 3
6 Minocycline in Clinically Isolated Syndromes (CIS) Completed NCT00666887 Phase 3
7 Clopidogrel and the Optimization of Gastrointestinal Events (COGENT-1) Terminated NCT00557921 Phase 3
8 Tolerability of Peginterferon Plus Ribavirin for Chronic Hepatitis C and HIV for Patients Receiving Antiretroviral Medication vs Not Receiving Antiretroviral Medication Terminated NCT00296972 Phase 3
9 An Intervention Program to Reduce to the Risk of Persistent Symptoms After Concussion Completed NCT00893347 Phase 2
10 Evaluation of Two Treatments for Chronic Post Concussion Syndrome Terminated NCT00871884 Phase 1, Phase 2
11 Central Pain Study for ABX-1431 Recruiting NCT03138421 Phase 1
12 Genetic Analysis of Fraser Syndrome and Fryns Syndrome Completed NCT00032877
13 The Use of Texting Messaging to Improve the Hospital-to-community Transition Period in Cardiovascular Disease Patients Completed NCT02336919
14 Comparison Between Infant Flow SiPAP and Noninvasive NAVA in the Neonatal Intensive Care Unit Completed NCT01588080
15 Serial Daily Diaphragm Ultrasounds in Ventilated Patients Completed NCT02174029
16 Collection of Blood Samples From SMART Study Participants for Future Genetic Studies Completed NCT00377169
17 INfrapatellar Versus SUprapatellar Reamed Intramedullary Nailing for Fractures of the Tibia Recruiting NCT02750072
18 A Multi-centre Trial of an Open Lung Strategy Including Permissive Hypercapnia, Alveolar Recruitment and Low Airway Pressure in Patients With Acute Respiratory Distress Syndrome Recruiting NCT01667146
19 Pediatric Vasculitis Initiative Recruiting NCT02006134
20 Natural History and Biology of Long-Term Late Effects Following Hematopoietic Cell Transplant for Childhood Hematologic Malignancies Recruiting NCT02338479
21 International Study of Comparative Health Effectiveness With Medical and Invasive Approaches (ISCHEMIA) Recruiting NCT01471522
22 Frailty in Elderly Patients Receiving Cardiac Interventional Procedures Active, not recruiting NCT02386124
23 Pregnancy in Osteogenesis Imperfecta (OI) Registry Not yet recruiting NCT03072303
24 High Energy High Protein Peptide Feed Study Not yet recruiting NCT03140371
25 PRCT: Comparing Two Procedures for Ulno-Carpal Abutment Syndrome. Terminated NCT00564980

Search NIH Clinical Center for Fraser Syndrome

Genetic Tests for Fraser Syndrome

Genetic tests related to Fraser Syndrome:

id Genetic test Affiliating Genes
1 Cryptophthalmos Syndrome 29

Anatomical Context for Fraser Syndrome

MalaCards organs/tissues related to Fraser Syndrome:

39
Skin, Kidney, Heart, Eye, Trachea, Testes, Tongue

Publications for Fraser Syndrome

Articles related to Fraser Syndrome:

(show top 50) (show all 106)
id Title Authors Year
1
Variable presentation of Fraser syndrome in two fetuses and a novel mutation in FRAS1. ( 27624506 )
2016
2
Prenatal diagnosis of Fraser syndrome using routine ultrasound examination, confirmed by exome sequencing - report of a novel homozygous missense FRAS1 mutation. ( 27341656 )
2016
3
Fraser syndrome: features suggestive of prenatal diagnosis in a review of 38 cases. ( 27859469 )
2016
4
Fraser Syndrome - a Case Report and Review of Literature. ( 28465758 )
2016
5
Frontal Encephalocele Associated With a Bilateral Tessier Number Three Cleft and Fraser Syndrome. ( 26267579 )
2015
6
Fraser syndrome with laryngeal webs: Report of two cases and a review of the literature. ( 26384833 )
2015
7
Reconstruction of Unilateral Incomplete Cryptophthalmos in Fraser Syndrome. ( 25811163 )
2015
8
A novel mutation in the FRAS1 gene in a patient with Fraser syndrome. ( 26043503 )
2015
9
Prenatal diagnosis of Fraser syndrome: a matter of life or death? ( 26552811 )
2015
10
Fraser Syndrome. ( 26522198 )
2015
11
Delivery of anesthesia and complications for children with Fraser syndrome: a review of 125 anesthetics. ( 25230075 )
2014
12
Mild recessive mutations in six Fraser syndrome-related genes cause isolated congenital anomalies of the kidney and urinary tract. ( 24700879 )
2014
13
Fraser syndrome-oral manifestations and a dental care protocol. ( 25587460 )
2014
14
Vaginal atresia in a case of fraser syndrome. ( 25404827 )
2014
15
Fraser syndrome due to mutations in GRIP1-Clinical phenotype in two families and expansion of the mutation spectrum. ( 24357607 )
2013
16
Expanding the mutation spectrum for Fraser syndrome: identification of a novel heterozygous deletion in FRAS1. ( 23473829 )
2013
17
Anesthetic management in a case of Fraser syndrome. ( 23717248 )
2013
18
Fraser syndrome: epidemiological study in a European population. ( 23532946 )
2013
19
Congenital High Airway Obstruction Syndrome (CHAOS) as part of Fraser syndrome: ultrasound and autopsy findings. ( 24551978 )
2013
20
Sprouty1 haploinsufficiency prevents renal agenesis in a model of Fraser syndrome. ( 23064016 )
2012
21
MRI findings of intracranial malformations in a case with Fraser syndrome. ( 22827970 )
2012
22
Expression of Fraser syndrome genes in normal and polycystic murine kidneys. ( 21993971 )
2012
23
Generation of mice with a conditional null Fraser syndrome 1 (Fras1) allele. ( 22730198 )
2012
24
Mutations in GRIP1 cause Fraser syndrome. ( 22510445 )
2012
25
Basement membrane assembly of the integrin I+8I^1 ligand nephronectin requires Fraser syndrome-associated proteins. ( 22613833 )
2012
26
Case report: hypodontia and short roots in a child with Fraser syndrome. ( 21806907 )
2011
27
Clinical and molecular studies in two families with Fraser syndrome: a new FRAS1 gene mutation, prenatal ultrasound findings and implications for genetic counselling. ( 22029163 )
2011
28
Fused pulmonary lobes is a rat model of human Fraser syndrome. ( 21756877 )
2011
29
Fraser syndrome in three consecutive siblings. ( 21897626 )
2011
30
Genetic analysis of fin development in zebrafish identifies furin and hemicentin1 as potential novel fraser syndrome disease genes. ( 20419147 )
2010
31
A surgical strategy for the correction of Fraser syndrome cryptophthalmos. ( 19643480 )
2009
32
Fraser syndrome: affected siblings born to nonconsanguineous parents and diagnosed at autopsy. ( 17990920 )
2008
33
Fraser syndrome: a new case report with review of the literature. ( 18568997 )
2008
34
Bilateral orbito-palpebral cysts in a case of cryptophthalmos associated with Fraser syndrome. ( 18083592 )
2008
35
Fras1, a basement membrane-associated protein mutated in Fraser syndrome, mediates both the initiation of the mammalian kidney and the integrity of renal glomeruli. ( 18787044 )
2008
36
The presence of bilateral hip dysplasia and genu valgum in Fraser syndrome. ( 19292157 )
2008
37
Fraser syndrome with partial anomalous pulmonary venous connection. ( 18599943 )
2008
38
Molecular study of 33 families with Fraser syndrome new data and mutation review. ( 18671281 )
2008
39
Fraser syndrome due to homozygosity for a splice site mutation of FREM2. ( 18203166 )
2008
40
Fraser syndrome. ( 19065328 )
2008
41
The Fras1/Frem family of extracellular matrix proteins: structure, function, and association with Fraser syndrome and the mouse bleb phenotype. ( 18661360 )
2008
42
Fraser syndrome. ( 18603689 )
2008
43
Quiz page April 2008: deafness, preauricular pits, and renal failure. BOR syndrome or Melnick-Fraser syndrome. ( 18371523 )
2008
44
Recurrent Fraser syndrome. ( 17266165 )
2007
45
Clinical manifestations and oral findings in Fraser syndrome. ( 18482521 )
2007
46
Noncompaction in Melnick Fraser syndrome. ( 17669095 )
2007
47
Fraser syndrome: a clinical study of 59 cases and evaluation of diagnostic criteria. ( 18000968 )
2007
48
Fraser syndrome: recurrence in a family. ( 18175849 )
2007
49
Intrafamilial variability in Fraser syndrome. ( 17546704 )
2007
50
Fraser syndrome in a 96-year-old female. ( 17047011 )
2006

Variations for Fraser Syndrome

UniProtKB/Swiss-Prot genetic disease variations for Fraser Syndrome:

66
id Symbol AA change Variation ID SNP ID
1 FREM2 p.Glu1972Lys VAR_023201

ClinVar genetic disease variations for Fraser Syndrome:

6 (show all 21)
id Gene Variation Type Significance SNP ID Assembly Location
1 FREM2 NM_207361.5(FREM2): c.5920G> A (p.Glu1974Lys) single nucleotide variant Pathogenic rs121434355 GRCh37 Chromosome 13, 39358846: 39358846
2 FREM2 FREM2, IVS14, G-A, +1 single nucleotide variant Pathogenic
3 FREM2 NM_207361.5(FREM2): c.5914G> A (p.Glu1972Lys) single nucleotide variant Pathogenic rs121434356 GRCh37 Chromosome 13, 39358840: 39358840
4 FRAS1 NM_025074.6(FRAS1): c.7522+1G> T single nucleotide variant Pathogenic rs730882180 GRCh38 Chromosome 4, 78472331: 78472331
5 FRAS1 NM_025074.6(FRAS1): c.8602C> T (p.Gln2868Ter) single nucleotide variant Pathogenic rs120074156 GRCh37 Chromosome 4, 79403116: 79403116
6 FRAS1 NM_025074.6(FRAS1): c.9013C> T (p.Gln3005Ter) single nucleotide variant Pathogenic rs120074157 GRCh37 Chromosome 4, 79418013: 79418013
7 FRAS1 FRAS1, 1-BP INS, 5605T insertion Pathogenic
8 FRAS1 NM_025074.6(FRAS1): c.3799C> T (p.Gln1267Ter) single nucleotide variant Pathogenic rs120074158 GRCh37 Chromosome 4, 79308679: 79308679
9 FRAS1 NM_025074.6(FRAS1): c.4271C> G (p.Ser1424Ter) single nucleotide variant Pathogenic rs120074159 GRCh37 Chromosome 4, 79328958: 79328958
10 FRAS1 NM_025074.6(FRAS1): c.5419_5424delTTCTCT (p.Phe1807_Ser1808del) deletion Pathogenic rs730882178 GRCh37 Chromosome 4, 79360108: 79360113
11 FRAS1 NM_025074.6(FRAS1): c.6963_6964dupGG (p.Val2322Glyfs) duplication Pathogenic rs730882179 GRCh37 Chromosome 4, 79385671: 79385672
12 GRIP1 NM_021150.3(GRIP1): c.2113+1G> C single nucleotide variant Pathogenic rs397514485 GRCh37 Chromosome 12, 66786456: 66786456
13 GRIP1 NM_021150.3(GRIP1): c.1181_1184delAAGA (p.Lys394Thrfs) deletion Pathogenic rs397514486 GRCh37 Chromosome 12, 66849203: 66849206
14 FRAS1 NM_025074.6(FRAS1): c.1931delG (p.Gly644Valfs) deletion Pathogenic rs794727195 GRCh37 Chromosome 4, 79238633: 79238633
15 FRAS1 NM_025074.6(FRAS1): c.2722+1G> A single nucleotide variant Pathogenic rs794727365 GRCh37 Chromosome 4, 79285209: 79285209
16 FRAS1 NM_025074.6(FRAS1): c.3370dupT (p.Ser1124Phefs) duplication Pathogenic rs797044696 GRCh37 Chromosome 4, 79300957: 79300957
17 FRAS1 NM_025074.6(FRAS1): c.370C> T (p.Arg124Ter) single nucleotide variant Pathogenic rs377046630 GRCh37 Chromosome 4, 79173606: 79173606
18 FRAS1 NM_025074.6(FRAS1): c.5664_5665+19delinsT indel Pathogenic rs886037766 GRCh38 Chromosome 4, 78441296: 78441316
19 FRAS1 NM_025074.6(FRAS1): c.10287delC (p.Tyr3429Terfs) deletion Pathogenic rs886037765 GRCh38 Chromosome 4, 78515911: 78515911
20 FRAS1 NM_025074.6(FRAS1): c.7551T> A (p.Tyr2517Ter) single nucleotide variant Pathogenic rs745597204 GRCh37 Chromosome 4, 79394620: 79394620
21 FREM2 NM_207361.5(FREM2): c.5954dupT (p.Met1985Ilefs) duplication Pathogenic rs886043213 GRCh37 Chromosome 13, 39358880: 39358880

Expression for Fraser Syndrome

Search GEO for disease gene expression data for Fraser Syndrome.

Pathways for Fraser Syndrome

Pathways related to Fraser Syndrome according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
10.82 ITGA8 ITGB1
2 10.38 ITGA8 ITGB1

GO Terms for Fraser Syndrome

Cellular components related to Fraser Syndrome according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 integrin complex GO:0008305 9.16 ITGA8 ITGB1
2 integrin alpha8-beta1 complex GO:0034678 8.96 ITGA8 ITGB1
3 basement membrane GO:0005604 8.92 FRAS1 FREM1 FREM2 FREM3

Biological processes related to Fraser Syndrome according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 embryonic limb morphogenesis GO:0030326 9.4 FRAS1 GREM1
2 morphogenesis of an epithelium GO:0002009 9.37 FRAS1 FREM2
3 cell adhesion GO:0007155 9.35 FREM1 FREM2 FREM3 ITGA8 ITGB1
4 cell-matrix adhesion GO:0007160 9.33 FREM1 ITGA8 ITGB1
5 cell migration involved in sprouting angiogenesis GO:0002042 9.32 GREM1 ITGB1
6 mesodermal cell differentiation GO:0048333 9.26 ITGA8 ITGB1
7 cell communication GO:0007154 8.92 FRAS1 FREM1 FREM2 FREM3

Sources for Fraser Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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