MCID: FRM001
MIFTS: 22

Freemartinism malady

Category: Endocrine diseases

Aliases & Classifications for Freemartinism

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Aliases & Descriptions for Freemartinism:

Name: Freemartinism 11 13 37 66

Classifications:



External Ids:

Disease Ontology11 DOID:4671
MeSH37 D005611

Summaries for Freemartinism

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MalaCards based summary: Freemartinism is related to anterograde amnesia and myxedema. An important gene associated with Freemartinism is AMH (Anti-Mullerian Hormone). Affiliated tissues include testis and ovary, and related mouse phenotype reproductive system.

Related Diseases for Freemartinism

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Diseases related to Freemartinism via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 34)
idRelated DiseaseScoreTop Affiliating Genes
1anterograde amnesia10.4AMELX, AMELY
2myxedema10.4AMELX, AMELY
3mature cataract10.4AMELX, AMELY
4urinary bladder inverted papilloma10.4AMELX, AMELY
5pneumatosis cystoides intestinalis10.4AMELX, AMELY
6paraphimosis10.4AMELX, AMELY
7breast myoepitheliosis10.3AMELX, AMELY
8polyneuropathy in collagen vascular disease10.3AMELX, AMELY
9urethra leiomyoma10.3AMELX, AMELY
10breast adenomyoepithelioma10.3AMELX, AMELY
11bone squamous cell carcinoma10.3AMELX, AMELY
12eosinophilic gastroenteritis10.1AMELX, AMELY
13hermaphroditism10.1
1448,xxxy syndrome10.1BMP15, SRY
15meacham syndrome10.1AMH, SRY
16chronic frontal sinusitis10.0AMH, GNRH1
17signet ring cell adenocarcinoma10.0AMH, SRY
18mental retardation, x-linked 10110.0AMH, BMP15
19dental pulp necrosis9.9AMH, GNRH1
20gender identity disorder9.9AMH, GNRH1
21ovarian hyperstimulation syndrome9.8AMH, GNRH1
22multiple synostoses syndrome9.8AMH, BMP15, SRY
23mixed gonadal dysgenesis9.7AMH, BMP15, SRY
24precursor b lymphoblastic lymphoma/leukemia9.7AMH, GNRH1
25cervix carcinoma9.6AMH, GNRH1
26pleural empyema9.6AMH, BMP15, GNRH1
27pseudopterygium9.5AMH, BMP15, GNRH1
28gaucher's disease9.5AMH, GNRH1, SRY
29hidradenitis9.5AMH, GNRH1, SRY
30diabetes mellitus, insulin-resistant, with acanthosis nigricans9.4AMH, GNRH1
31benign paroxysmal positional nystagmus9.3BMP15, GNRH1, SRY
32lateral sclerosis9.1AMH, BMP15, GNRH1, OXT
33candidiasis8.5AMH, BMP15, GNRH1, OXT, SRY
34uremia7.3AMELX, AMELY, AMH, BMP15, GNRH1, NR1I2

Graphical network of the top 20 diseases related to Freemartinism:



Diseases related to freemartinism

Symptoms for Freemartinism

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Drugs & Therapeutics for Freemartinism

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Freemartinism


Cochrane evidence based reviews: freemartinism

Genetic Tests for Freemartinism

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Anatomical Context for Freemartinism

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MalaCards organs/tissues related to Freemartinism:

34
Testis, Ovary

Animal Models for Freemartinism or affiliated genes

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MGI Mouse Phenotypes related to Freemartinism:

39
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053897.8AMH, BMP15, GNRH1, NR1I2, OXT

Publications for Freemartinism

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Articles related to Freemartinism:

(show all 27)
idTitleAuthorsYear
1
Dizygotic monochorionic canine fetuses with blood chimaerism and suspected freemartinism. (26304144)
2015
2
Freemartinism and FecXR allele determination in replacement ewes of the Rasa Aragonesa sheep breed by duplex PCR. (19773062)
2009
3
Diagnosis of bovine freemartinism by fluorescence in situ hybridization on interphase nuclei using a bovine Y chromosome-specific DNA probe. (17870153)
2007
4
Comparison of cytogenetics and polymerase chain reaction based detection of the amelogenin gene polymorphism for the diagnosis of freemartinism in cattle. (17037616)
2006
5
Freemartinism in river buffalo: clinical and cytogenetic observations. (15627757)
2005
6
XX/XY chimerism and freemartinism in a female llama co-twin to a male. (10530330)
1999
7
The diagnosis of freemartinism in cattle using sex-specific DNA sequences. (10425251)
1999
8
Freemartinism among singleton bovine females born from multiple embryo transfer. (16727729)
1995
9
Development of the gubernaculum and processus vaginalis in freemartinism: further evidence in support of a specific fetal testis hormone governing male-specific gubernacular development. (7710137)
1995
10
Diagnosis of freemartinism in cattle: the need for clinical and cytogenic evaluation. (8050953)
1994
11
A fast and highly sensitive method for detecting freemartinism in bovine twins using immunomagnetic beads and Y-specific PCR primers. (8239077)
1993
12
Diagnosis of bovine freemartinism by the polymerase chain reaction method. (1362861)
1992
13
Freemartinism in a captive herd of Rocky Mountain bighorn sheep (Ovis canadensis). (1512891)
1992
14
Freemartinism in red deer (Cervus elaphus L.). (2249475)
1990
15
Diagnosis of freemartinism in sheep. (2916299)
1989
16
Anti-mA1llerian hormone and freemartinism: inhibition of germ cell development and induction of seminiferous cord-like structures in rat fetal ovaries exposed in vitro to purified bovine AMH. (3244905)
1988
17
Sex chromatin as a useful tool for detection of freemartinism in bovine twins. (3995247)
1985
18
Probable freemartinism in a goat. (7193198)
1980
19
Heifer sterility associated with single-birth freemartinism. (867757)
1977
20
A study of bovine freemartinism-morphological variations of the genitalia and sex-chromosome chimerism. (873602)
1977
21
Heifer sterility and freemartinism. (560082)
1977
22
The incidence of freemartinism in sheep. (5099639)
1971
23
Blood cell chimerism and freemartinism in heterosexual bovine quadruplets. (5480932)
1970
24
XX-XY chimerism in a bovine true hermaphrodite: an insight into the understanding of freemartinism. (5702324)
1968
25
The leukocyte culture method in the diagnosis of freemartinism. (4234791)
1968
26
Attempts to induce bovine freemartinism experimentally. (5891100)
1965
27
BOVINE FREEMARTINS AND TRUE HERMAPHRODITISM. (14283739)
1965

Variations for Freemartinism

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Expression for genes affiliated with Freemartinism

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Search GEO for disease gene expression data for Freemartinism.

Pathways for genes affiliated with Freemartinism

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GO Terms for genes affiliated with Freemartinism

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Biological processes related to Freemartinism according to GeneCards Suite gene sharing:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1biomineral tissue developmentGO:00312149.9AMELX, AMELY
2response to prostaglandin EGO:00346959.7GNRH1, OXT
3response to peptide hormoneGO:00434349.5GNRH1, OXT
4female pregnancyGO:00075659.4GNRH1, OXT
5male sex determinationGO:00302389.2GNRH1, SRY
6response to organic cyclic compoundGO:00140709.1AMH, GNRH1, OXT
7response to steroid hormoneGO:00485458.8GNRH1, OXT
8signal transductionGO:00071658.3AMELX, GNRH1, NR1I2, OXT

Molecular functions related to Freemartinism according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1structural constituent of tooth enamelGO:003034510.2AMELX, AMELY
2transforming growth factor beta receptor bindingGO:000516010.0AMH, BMP15
3hormone activityGO:00051799.5AMH, GNRH1
4growth factor activityGO:00080839.2AMELX, AMH, BMP15

Sources for Freemartinism

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet