MCID: FRM001
MIFTS: 25

Freemartinism malady

Category: Endocrine diseases

Aliases & Classifications for Freemartinism

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Aliases & Descriptions for Freemartinism:

Name: Freemartinism 10 12 36 65

Classifications:



External Ids:

Disease Ontology10 DOID:4671
MeSH36 D005611
UMLS65 C0016697

Summaries for Freemartinism

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MalaCards based summary: Freemartinism is related to hermaphroditism and 46 xx gonadal dysgenesis. An important gene associated with Freemartinism is AMH (Anti-Mullerian Hormone). Affiliated tissues include heart, testis and lymph node, and related mouse phenotypes are endocrine/exocrine gland and reproductive system.

Related Diseases for Freemartinism

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Graphical network of the top 20 diseases related to Freemartinism:



Diseases related to freemartinism

Symptoms for Freemartinism

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Drugs & Therapeutics for Freemartinism

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Freemartinism


Cochrane evidence based reviews: freemartinism

Genetic Tests for Freemartinism

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Anatomical Context for Freemartinism

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MalaCards organs/tissues related to Freemartinism:

33
Heart, Testis, Lymph node, Spleen, Smooth muscle, Breast, T cells

Animal Models for Freemartinism or affiliated genes

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MGI Mouse Phenotypes related to Freemartinism:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053798.1AMH, BMP15, GNRH1, OXT
2MP:00053897.7AMH, BMP15, GNRH1, NR1I2, OXT

Publications for Freemartinism

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Articles related to Freemartinism:

(show all 28)
idTitleAuthorsYear
1
Dizygotic monochorionic canine fetuses with blood chimaerism and suspected freemartinism. (26304144)
2015
2
Freemartinism and FecXR allele determination in replacement ewes of the Rasa Aragonesa sheep breed by duplex PCR. (19773062)
2009
3
Diagnosis of bovine freemartinism by fluorescence in situ hybridization on interphase nuclei using a bovine Y chromosome-specific DNA probe. (17870153)
2007
4
Comparison of cytogenetics and polymerase chain reaction based detection of the amelogenin gene polymorphism for the diagnosis of freemartinism in cattle. (17037616)
2006
5
Freemartinism in river buffalo: clinical and cytogenetic observations. (15627757)
2005
6
XX/XY chimerism and freemartinism in a female llama co-twin to a male. (10530330)
1999
7
The diagnosis of freemartinism in cattle using sex-specific DNA sequences. (10425251)
1999
8
Freemartinism among singleton bovine females born from multiple embryo transfer. (16727729)
1995
9
Development of the gubernaculum and processus vaginalis in freemartinism: further evidence in support of a specific fetal testis hormone governing male-specific gubernacular development. (7710137)
1995
10
Diagnosis of freemartinism in cattle: the need for clinical and cytogenic evaluation. (8050953)
1994
11
A fast and highly sensitive method for detecting freemartinism in bovine twins using immunomagnetic beads and Y-specific PCR primers. (8239077)
1993
12
Diagnosis of bovine freemartinism by the polymerase chain reaction method. (1362861)
1992
13
Freemartinism in a captive herd of Rocky Mountain bighorn sheep (Ovis canadensis). (1512891)
1992
14
Freemartinism in red deer (Cervus elaphus L.). (2249475)
1990
15
Diagnosis of freemartinism in sheep. (2916299)
1989
16
Anti-mA1llerian hormone and freemartinism: inhibition of germ cell development and induction of seminiferous cord-like structures in rat fetal ovaries exposed in vitro to purified bovine AMH. (3244905)
1988
17
Sex chromatin as a useful tool for detection of freemartinism in bovine twins. (3995247)
1985
18
Probable freemartinism in a goat. (7193198)
1980
19
Heifer sterility associated with single-birth freemartinism. (867757)
1977
20
A study of bovine freemartinism-morphological variations of the genitalia and sex-chromosome chimerism. (873602)
1977
21
Heifer sterility and freemartinism. (560082)
1977
22
The incidence of freemartinism in sheep. (5099639)
1971
23
Blood cell chimerism and freemartinism in heterosexual bovine quadruplets. (5480932)
1970
24
XX-XY chimerism in a bovine true hermaphrodite: an insight into the understanding of freemartinism. (5702324)
1968
25
The leukocyte culture method in the diagnosis of freemartinism. (4234791)
1968
26
Attempts to induce bovine freemartinism experimentally. (5891100)
1965
27
BOVINE FREEMARTINS AND TRUE HERMAPHRODITISM. (14283739)
1965
28

Variations for Freemartinism

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Expression for genes affiliated with Freemartinism

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Search GEO for disease gene expression data for Freemartinism.

Pathways for genes affiliated with Freemartinism

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GO Terms for genes affiliated with Freemartinism

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Biological processes related to Freemartinism according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1response to organic cyclic compoundGO:00140709.5AMH, OXT
2response to steroid hormoneGO:00485459.4GNRH1, OXT
3male sex determinationGO:00302389.3GNRH1, SRY
4response to prostaglandin EGO:00346959.1GNRH1, OXT
5female pregnancyGO:00075659.0GNRH1, OXT
6response to peptide hormoneGO:00434348.8GNRH1, OXT

Sources for Freemartinism

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet