MCID: FRM001
MIFTS: 24

Freemartinism malady

Category: Endocrine diseases

Aliases & Classifications for Freemartinism

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Aliases & Descriptions for Freemartinism:

Name: Freemartinism 10 12 36 65

Classifications:



External Ids:

Disease Ontology10 DOID:4671
MeSH36 D005611
UMLS65 C0016697

Summaries for Freemartinism

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MalaCards based summary: Freemartinism is related to myocardial infarction and hepatocellular carcinoma. An important gene associated with Freemartinism is AMH (Anti-Mullerian Hormone). Affiliated tissues include spleen, heart and lymph node, and related mouse phenotypes are endocrine/exocrine gland and reproductive system.

Related Diseases for Freemartinism

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Diseases related to Freemartinism via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 43)
idRelated DiseaseScoreTop Affiliating Genes
1myocardial infarction10.2
2hepatocellular carcinoma10.2
3breast cancer10.2
4obesity10.2
5keratopathy10.2
6usher syndrome10.2
7bullous keratopathy10.2
8heart disease10.2
9cholestasis10.2
10inclusion body myositis10.2
11choriocarcinoma10.2
12myositis10.2
13hepatoblastoma10.2
14pemphigus10.2
15mycetoma10.2
16left ventricular outflow tract obstruction10.2
17dysphagia10.2
18pemphigus erythematosus10.2
1946 xx gonadal dysgenesis10.1AMH, SRY
2048,xxxy syndrome10.0BMP15, SRY
21meacham syndrome10.0AMH, SRY
22alternating hemiplegia of childhood10.0AMH, SRY
23fabry disease10.0AMH, BMP15
24setariasis9.9AMH, GNRH1
25retroperitoneal lymphoma9.9AMH, GNRH1
26hematocele of tunica vaginalis testis9.9GNRH1, OXT
27prostatocystitis9.9GNRH1, OXT
28nodular episcleritis9.8GNRH1, OXT
29sex differentiation disease9.8AMH, GNRH1
30external ear disease9.8BMP15, GNRH1
31mixed connective tissue disease9.8AMH, SRY
32ovarian hyperstimulation syndrome9.8AMH, GNRH1
33short qt syndrome9.8AMH, BMP15, SRY
3446 xy gonadal dysgenesis9.8AMH, BMP15, SRY
35leydig cell tumor9.7GNRH1, OXT
36anorectal stricture9.6AMH, BMP15, GNRH1
37hypogonadism9.6AMH, GNRH1, SRY
38hidradenitis suppurativa9.6AMH, GNRH1, SRY
39leprechaunism9.6AMH, GNRH1
40urinary schistosomiasis9.5BMP15, GNRH1, SRY
41leptospirosis9.3AMH, BMP15, GNRH1, OXT
42disease of mental health8.9AMH, BMP15, GNRH1, OXT, SRY
43uremic neuropathy8.7AMH, BMP15, GNRH1, NR1I2, OXT, SRY

Graphical network of the top 20 diseases related to Freemartinism:



Diseases related to freemartinism

Symptoms for Freemartinism

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Drugs & Therapeutics for Freemartinism

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Freemartinism


Cochrane evidence based reviews: freemartinism

Genetic Tests for Freemartinism

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Anatomical Context for Freemartinism

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MalaCards organs/tissues related to Freemartinism:

33
Spleen, Heart, Lymph node, T cells, Smooth muscle

Animal Models for Freemartinism or affiliated genes

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MGI Mouse Phenotypes related to Freemartinism:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053798.1AMH, BMP15, GNRH1, OXT
2MP:00053897.7AMH, BMP15, GNRH1, NR1I2, OXT

Publications for Freemartinism

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Articles related to Freemartinism:

(show all 27)
idTitleAuthorsYear
1
Association between interleukin-6 gene polymorphisms and rheumatoid arthritis in Chinese Han population: a case-control study and a meta-analysis. (25030201)
2014
2
Reduced expression of ZDHHC2 is associated with lymph node metastasis and poor prognosis in gastric adenocarcinoma. (23457560)
2013
3
Transition in Duchenne muscular dystrophy: An expert meeting report and description of transition needs in an emergent patient population: (Parent Project Muscular Dystrophy Transition Expert Meeting 17-18 June 2011, Amsterdam, The Netherlands). (22989602)
2013
4
Rare case of desmoid-type fibromatosis of the mandibular region in a child: diagnosis and surgical management. (24313589)
2013
5
Irreversible electroporation: A novel pancreatic cancer therapy. (24331180)
2013
6
Non-insertional tendinopathy of the subscapularis. (24167399)
2013
7
Secular and seasonal trends of infectious mononucleosis among young adults in Israel: 1978-2009. (21809084)
2012
8
Progressive epidural lipomatosis with steroid use in severe refractory asthma. (21341972)
2011
9
Is gestational diabetes mellitus an important contributor to metabolic disorders in trinidad and tobago? (19946648)
2009
10
Clinical prognostic significance of plasma cystatin C levels among patients with acute coronary syndrome. (19938052)
2009
11
Constitutive IL-8 expression in cancer cells is associated with mutation of p53. (15945132)
2005
12
MutYH (MYH) and colorectal cancer. (16042573)
2005
13
Beta(2)-adrenergic receptor gene polymorphism, age, and cardiovascular phenotypes. (12574108)
2003
14
Amantadine]. (14619440)
2003
15
Heart-directed autoimmunity: the case of rheumatic fever. (11334505)
2001
16
Characterization of the human complex I NDUFB7 and 17.2-kDa cDNAs and mutational analysis of 19 genes of the HP fraction in complex I- deficient-patients. (10830904)
2000
17
The roles of activin and follistatin signaling in chick gastrulation. (9694626)
1998
18
A subpopulation of estrogen receptors are modified by O-linked N- acetylglucosamine. (8999954)
1997
19
Fluoride at mitogenic doses induces a sustained activation of p44mapk, but not p42mapk, in human TE85 osteosarcoma cells. (9100584)
1997
20
Upper esophageal sphincter myotomy in oculopharyngeal muscular dystrophy: long-term clinical results. (9392024)
1997
21
A direct role of transcription factor E2F in c-myc gene expression during granulocytic and macrophage-like differentiation of HL60 cells. (7794791)
1995
22
Effect of passive sensitization on the mechanical activity of human isolated bronchial smooth muscle induced by substance P, neurokinin A and VIP. (7684296)
1993
23
Interleukin-6 regulates the cytotoxic effect of tumour necrosis factor on U937 cells. (1317349)
1992
24
HLA-DR alleles differ in their ability to present staphylococcal enterotoxins to T cells. (2117633)
1990
25
Splenic infarction and spontaneous rupture of the spleen after therapeutic embolization. (743720)
1978
26
Infant botulism--a new disease for an old organism. (732682)
1978
27

Variations for Freemartinism

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Expression for genes affiliated with Freemartinism

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Search GEO for disease gene expression data for Freemartinism.

Pathways for genes affiliated with Freemartinism

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GO Terms for genes affiliated with Freemartinism

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Biological processes related to Freemartinism according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1response to organic cyclic compoundGO:00140709.5AMH, OXT
2response to steroid hormoneGO:00485459.4GNRH1, OXT
3male sex determinationGO:00302389.3GNRH1, SRY
4response to prostaglandin EGO:00346959.1GNRH1, OXT
5female pregnancyGO:00075659.0GNRH1, OXT
6response to peptide hormoneGO:00434348.8GNRH1, OXT

Sources for Freemartinism

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet