MCID: FRM001
MIFTS: 22

Freemartinism malady

Summaries for Freemartinism

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32MalaCards
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MalaCards: Freemartinism is related to hermaphroditism and anovulation. An important gene associated with Freemartinism is AMELY (amelogenin, Y-linked). Affiliated tissues include ovary and testis.

Aliases & Classifications for Freemartinism

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8Disease Ontology, 60UMLS, 34MeSH
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Aliases & Descriptions:

freemartinism 8 60


External Ids:

Disease Ontology8 DOID:4671
MeSH34 D005611

Related Diseases for Freemartinism

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17GeneCards, 18GeneDecks
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Diseases related to Freemartinism via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 11)
idRelated DiseaseScoreTop Affiliating Genes
1hermaphroditism10.2
2anovulation10.0AMH
3root resorption10.0AMELX
4azoospermia10.0AMH
5turner syndrome10.0AMELX, AMELY
6dental pulp necrosis10.0AMELX, AMELY
7dental fluorosis10.0AMELX, AMELY
8amelogenesis imperfecta10.0AMELY, AMELX
9amenorrhea10.0BMP15, AMH
10polycystic ovary syndrome10.0BMP15, AMH
11premature ovarian failure10.0BMP15, AMH

Graphical network of diseases related to Freemartinism:



Diseases related to freemartinism

Clinical Features for Freemartinism

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Drugs & Therapeutics for Freemartinism

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Freemartinism

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Anatomical Context for Freemartinism

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32MalaCards
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MalaCards organs/tissues related to Freemartinism:

32
Ovary, Testis

Animal Models for Freemartinism or affiliated genes

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Publications for Freemartinism

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50PubMed
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Articles related to Freemartinism:

(show all 26)
idTitleAuthorsYear
1
Freemartinism and FecXR allele determination in replacement ewes of the Rasa Aragonesa sheep breed by duplex PCR. (19773062)
2009
2
Diagnosis of bovine freemartinism by fluorescence in situ hybridization on interphase nuclei using a bovine Y chromosome-specific DNA probe. (17870153)
2007
3
Comparison of cytogenetics and polymerase chain reaction based detection of the amelogenin gene polymorphism for the diagnosis of freemartinism in cattle. (17037616)
2006
4
Freemartinism in river buffalo: clinical and cytogenetic observations. (15627757)
2005
5
XX/XY chimerism and freemartinism in a female llama co-twin to a male. (10530330)
1999
6
The diagnosis of freemartinism in cattle using sex-specific DNA sequences. (10425251)
1999
7
Freemartinism among singleton bovine females born from multiple embryo transfer. (16727729)
1995
8
Development of the gubernaculum and processus vaginalis in freemartinism: further evidence in support of a specific fetal testis hormone governing male-specific gubernacular development. (7710137)
1995
9
Diagnosis of freemartinism in cattle: the need for clinical and cytogenic evaluation. (8050953)
1994
10
A fast and highly sensitive method for detecting freemartinism in bovine twins using immunomagnetic beads and Y-specific PCR primers. (8239077)
1993
11
Diagnosis of bovine freemartinism by the polymerase chain reaction method. (1362861)
1992
12
Freemartinism in a captive herd of Rocky Mountain bighorn sheep (Ovis canadensis). (1512891)
1992
13
Freemartinism in red deer (Cervus elaphus L.). (2249475)
1990
14
Diagnosis of freemartinism in sheep. (2916299)
1989
15
Anti-mA1llerian hormone and freemartinism: inhibition of germ cell development and induction of seminiferous cord-like structures in rat fetal ovaries exposed in vitro to purified bovine AMH. (3244905)
1988
16
Sex chromatin as a useful tool for detection of freemartinism in bovine twins. (3995247)
1985
17
Probable freemartinism in a goat. (7193198)
1980
18
Heifer sterility associated with single-birth freemartinism. (867757)
1977
19
A study of bovine freemartinism-morphological variations of the genitalia and sex-chromosome chimerism. (873602)
1977
20
Heifer sterility and freemartinism. (560082)
1977
21
The incidence of freemartinism in sheep. (5099639)
1971
22
Blood cell chimerism and freemartinism in heterosexual bovine quadruplets. (5480932)
1970
23
XX-XY chimerism in a bovine true hermaphrodite: an insight into the understanding of freemartinism. (5702324)
1968
24
The leukocyte culture method in the diagnosis of freemartinism. (4234791)
1968
25
Attempts to induce bovine freemartinism experimentally. (5891100)
1965
26
BOVINE FREEMARTINS AND TRUE HERMAPHRODITISM. (14283739)
1965

Genetic Variations for Freemartinism

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Expression for genes affiliated with Freemartinism

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Freemartinism

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Pathways for genes affiliated with Freemartinism

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Compounds for genes affiliated with Freemartinism

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GO Terms for genes affiliated with Freemartinism

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16Gene Ontology
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Cellular components related to Freemartinism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1proteinaceous extracellular matrixGO:0055789.3AMELX, AMELY

Biological processes related to Freemartinism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1biomineral tissue developmentGO:0312149.3AMELX, AMELY

Molecular functions related to Freemartinism according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1structural constituent of tooth enamelGO:0303459.0AMELX, AMELY
2growth factor activityGO:0080838.5BMP15, AMH, AMELX

Products for genes affiliated with Freemartinism

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  • Antibodies
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  • Antibodies

Sources for Freemartinism

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet