MCID: FRY001
MIFTS: 29

Frey Syndrome malady

Rare diseases, Neuronal diseases, Smell/Taste diseases categories

Aliases & Classifications for Frey Syndrome

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Aliases & Descriptions for Frey Syndrome:

Name: Frey Syndrome 10 45 12
Sweating, Gustatory 65 36
Gustatory Sweating 10 45
Auriculotemporal Nerve Syndrome 45
Auriculotemporal Syndrome 65
 
Gustatory Hyperhidrosis 10
Hyperhidrosis Gustatory 45
Baillarger Syndrome 10
Frey's Syndrome 45


Classifications:



External Ids:

Disease Ontology10 DOID:11599
SNOMED-CT59 56046002, 238758008
MeSH36 D013547

Summaries for Frey Syndrome

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NIH Rare Diseases:45 Frey's syndrome is a rare neurological disorder that results from injury or surgery near the parotid glands (which manufacture saliva), damaging the facial nerve. the parotid glands are the largest salivary glands and are located on the side of the face below and in front of the ear. this syndrome is characterized by flushing or sweating on one side of the face when certain foods are consumed. the symptoms usually are mild and well tolerated by most individuals. relief from symptoms may require treatment in some cases. last updated: 5/25/2011

MalaCards based summary: Frey Syndrome, also known as sweating, gustatory, is related to food allergy and rheumatoid arthritis, and has symptoms including autosomal dominant inheritanceand hyperhidrosis. An important gene associated with Frey Syndrome is ATP2A2 (ATPase, Ca++ Transporting, Cardiac Muscle, Slow Twitch 2), and among its related pathways is Myometrial Relaxation and Contraction Pathways. Affiliated tissues include salivary gland, testes and skin, and related mouse phenotypes are tumorigenesis and integument.

Related Diseases for Frey Syndrome

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Diseases related to Frey Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 14)
idRelated DiseaseScoreTop Affiliating Genes
1food allergy10.2
2rheumatoid arthritis10.2
3arthritis10.2
4cerebellopontine angle meningioma10.2
5amyloidosis10.2
6autonomic neuropathy10.2
7neuropathy10.2
8salivary gland disease10.2
9neurofibromatosis10.1
10melanoma10.1
11benign secondary hypertension9.9ATP2A2, KANTR
12precursor t-lymphoblastic lymphoma/leukemia refractory9.9KANTR, NF1
13carotid artery disease9.8ATP2A2, KANTR
14strawberry gallbladder9.3ATP2A2, ETS2, KANTR, NF1

Graphical network of diseases related to Frey Syndrome:



Diseases related to frey syndrome

Symptoms for Frey Syndrome

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HPO human phenotypes related to Frey Syndrome:

id Description Frequency HPO Source Accession
1 autosomal dominant inheritance HP:0000006
2 hyperhidrosis HP:0000975

Drugs & Therapeutics for Frey Syndrome

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Drugs for Frey Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
AsenapineapprovedPhase 45385650-56-2, 65576-45-63001386, 11954293
Synonyms:
135882-95-0
1H-Dibenz[2,3:6,7]oxepino[4,5-c]pyrrole, 5-chloro-2,3,3a,12b-tetrahydro-2-met
5-chloro-2,3,3a,12b-tetrahydro-2-methyl-1H-dibenz(2,3-6,7)oxepino(4,5-c)pyrrole
65576-45-6
AC1L4SHR
Asenapi
Asenapine
Asenapine Maleate
Asenapine [INN:BAN]
CHEMBL504548
 
CID163091
EINECS 265-829-4
I14-8821
Org 5222
Org-5222
PDSP1_001600
PDSP2_001584
Saphris
UNII-JKZ19V908O
[13C,2H3]-Asenipine
trans-5-Chloro-2,3,3a,12b-tetrahydro-2-methyl-1H-dibenz(2,3:6,7)oxepino(4,5-c)pyrrole
2
BenzocaineapprovedPhase 215361994-09-7, 94-09-72337
Synonyms:
(p-(Ethoxycarbonyl)phenylamine
06952_FLUKA
112909_ALDRICH
112909_SIAL
1333-08-0
20/20 Topical Anesthetic
23239-88-5
23239-88-5 (hydrochloride)
4 Aminobenzoic Acid Ethyl Ester
4-(Ethoxycarbonyl)aniline
4-(Ethoxycarbonyl)phenylamine
4-14-00-01129 (Beilstein Handbook Reference)
4-Aminobenzoate
4-Aminobenzoic acid
4-Aminobenzoic acid ethyl ester
4-Aminobenzoic acid, ethyl ester
4-Carbethoxyaniline
4-amino-benzoic acid ethyl ester
4-aminobenzoic acid ethyl ester
71123-91-6
94-09-7
94-09-7 (Parent)
A0271
AB00051923
AC1L1DGC
AC1Q341A
AC1Q64JE
AE-562/40377256
AI3-02081
AKOS000119763
AR-1H9065
Acetate, Benzocaine
Aethoform
Aethylium paraminobenzoicum
Alcohol Prep Pads
Allegenal-m
Alpha-caine Topical Anesthetic
Amben ethyl ester
Americaine
Anaesthan-syngala
Anaesthesin
Anaesthesinum
Anaesthin
Anbesol Jr
Anbesol Maximum Strength
Anbesol Regular Strength
Anestenka
Anestezin
Anestezin [Russian]
Anesthesin
Anesthesine
Anesthetic
Anesthone
Atopalm Oral Pain Relief
BB_SC-0019
BPBio1_001017
BRD-K75466013-001-05-2
BRN 0638434
BSPBio_000923
BSPBio_001908
Baby Anbesol
Baby Anestenka
Baby Sensigel
Baby Sensigel Night Time Formula
Baby Teething Oral Pain Reliever
Bactimicina For Sore Throat
Bencocaine Topical Anesthetic
Bensokain
Benz O Sthetic
Benzoak
Benzocaina
Benzocaina [INN-Spanish]
Benzocaine
Benzocaine (USP/INN)
Benzocaine Acetate
Benzocaine Formate
Benzocaine Hydrobromide
Benzocaine Hydrochloride
Benzocaine Methanesulfonate
Benzocaine [INN:BAN]
Benzocainum
Benzocainum [INN-Latin]
Benzodent
Benzoic acid, 4-amino-, ethyl ester
Benzoic acid, 4-amino-, ethyl ester, hydrochloride
Benzoic acid, amino-, ethyl ester
Benzoic acid, p-amino-, ethyl ester
Boil Ease
Boy Butter Desensitizing Lubricant
Boy Butter Extreme Desensitizing Lubricant
Boy Butter Extreme H2O Desensitizing Lubricant
Brace Relief
Budpak Baby Teething Oral Pain Reliever
Budpak Oral Maximum Strength
C07527
CAS-94-09-7
CHEBI:116735
CHEMBL278172
CID2337
Carmex Cold Sore Treatment External Analgesic
Caswell No. 430A
Cepacol Fizzlers
Cepacol Sensations Hydra
Cepacol Sensations Sore Throat Hydra citrus splash
Cepacol Sensations Warming
Certus Sting Relief Prep Pad
Chloraseptic
Chloraseptic Warming Sore Throat
Colgate Orabase
Comfortcaine Topical Anesthetic
Cvs Fast Acting Baby Teething
Cvs Maximum Strength
Cvs Maximum Strength Boil Relief
Cvs Oral Anesthetic
Cvs Pharmacy Instant Toothache
Cvs Pharmacy Maximum Strength
Cvs Pharmacy Mouth Sore Gel
Cvs Pharmacy Nighttime Oral Pain Relief
D001566
D00552
DB01086
Dental Relief
Dentek Instant Pain Relief Maximum Strength
Dermoplast
Diet Ayds
DivK1c_000932
Dollar General Toothache Relief
Dukal Sting Relief Pad
E1501_SIGMA
EINECS 202-303-5
EPA Pesticide Chemical Code 097001
ETHYL-P-AMINOBENZOATE
Ethoform
Ethoforme
Ethyl 4-aminobenzoate
Ethyl 4-aminobenzoate hydrochloride
Ethyl 4-aminobenzoic acid
Ethyl Aminobenzoate
Ethyl PABA
Ethyl aminobenzoate
Ethyl aminobenzoate (JP15)
Ethyl aminobenzoate (VAN)
Ethyl aminobenzoic acid
Ethyl p-Aminobenzoate
Ethyl p-Aminophenylcarboxylate
Ethyl p-aminobenzenecarboxylate
Ethyl p-aminobenzoate
Ethyl p-aminobenzoic acid
Ethyl p-aminophenylcarboxylate
Ethylester kyseliny p-aminobenzoove
Ethylester kyseliny p-aminobenzoove [Czech]
Ethylis aminobenzoas
Finafta Baby
Finafta MultiOral
Formate, Benzocaine
Gelato Topical Anesthetic
Good Neighbor Pain Relief
Goodsense Oral Pain Relief
Gps Topical Anesthetic
Gumnumb Topical Anesthetic
HMS1570O05
HMS1920G09
HMS2091M11
HMS502O14
HSDB 7225
Heb Severe Toothache
Herbasoul Male Genital Desensitizer Cream
 
Hurricaine
Hurricaine Topical Anesthetic
Hurricaine Topical Anesthetic Gel
Hurricaine Topical Anesthetic Liquid
Hydrobromide, Benzocaine
Hydrochloride, Benzocaine
I05-0204
IDI1_000932
Identhesin
Insect Bite Relief
Instant Toothache Pain Relief
Intense Cvs Intense Toothache
Iodent Maximum Strength Oral Analgesic
Ismile Topical Anesthetic
Jianze Sting Relief Pads
KBio1_000932
KBio2_000474
KBio2_003042
KBio2_005610
KBio3_001408
KBioGR_000658
KBioSS_000474
Kank-a Mouth Pain
Keloform
Kmart Smart Sense
Kroger Toothache Pain Relief
LS-35847
Leader Oral Analgesic
Little Colds Sore Throat Relief Melt Aways
MLS001331704
MLS002153970
Makesense Junior Pain Relief
Makesense Pain Relief
Male Desensitizer Pleasure Balm
Mandelay Male Genital Desensitizer
Mark 3
Methanesulfonate, Benzocaine
MolPort-000-871-526
Mouth Sore Medication
Mouth Sore Relief Applicator
Mouth Sore Relief Professional Strength
My Fair Baby Instant Pain Relief
NCGC00016352-01
NCGC00094598-01
NCGC00094598-02
NINDS_000932
NSC 122792
NSC 41531
NSC41531
NSC4688
Nene Dente
Norcain
Norcaine
Norcainum
Opahl
Opahl Dye Free
Oprea1_750694
Oprea1_827402
Ora-jel
Orabase-B
Orajel For All Mouth Sores Maximum Strength
Orajel For Cold Sores
Orajel For Toothache Maximum Strength
Orajel Instant Pain Relief Maximum Strength
Orajel Instant Pain Relief Regular Strength
Orajel Instant Relief For Teething Pain
Orajel Instant Relief For Teething Pain Cooling Cucumber
Orajel Instant Relief For Teething Pain Daytime Nighttime Twin Pack
Orajel Instant Relief For Teething Pain Longer Lasting
Orajel Maximum Strength
Orajel Nighttime Instant Relief For Teething Pain Longer Lasting Extra Strength
Orajel Severe Toothache Maximum Strength Fast-Acting Formula
Oral Analgesic Maximum Strength
Oral B Instant Pain Relief
Oral Gel Maximum Strength
Oral Pain Relief Anesthetic Anesthetic
Oral Pain Reliever
Oralabs Cold Sore Treatment
Orthesin
Otocain
Outgro
Pac-dent Top Gel
Pain Relief
Pain Relief Alcohol Swabs
Parathesin
Parathesin (TN)
Parathesine
Physicians Care Sting Relief Pad
Pleasure Balm Kama Sutra
Preboost
Prestwick0_000712
Prestwick1_000712
Prestwick2_000712
Prestwick3_000712
Prestwick_991
Purelife Topical Anesthetic
Quality Choice Maximum Strength Oral Pain Relieving
Red Cross Oral Pain Relief
Rexall Maximum Strength
Rite Aid Baby Care
Rite Aid Liquid Anesthetic Oral Pain Relief
Rite Aid Maximum Strength
Rite Aid Oral Pain Reliever
Rite Aid Professional Strength
SMR000059025
SPBio_000134
SPBio_002844
SPECTRUM1500139
STK043620
Sally Hansen Ouch-relief Numbing Wipes
Sally Hansen Ouch-relief Wax Kit
Sally Hansen Ouch-relief Wax Strip Kit
Sensigel
Severe Oral Pain Reliever
Sheffield Baby Teething Gel
Sheffield Pain Relief
Shunga Male Genital Desensitizer
Slim Mint Gum
Solarcaine
Solu H
Spectrum2_000117
Spectrum3_000314
Spectrum4_000249
Spectrum5_000860
Spectrum_000074
Sting Relief Medicated Pad
Sting Relief Pads
Tanac
Terrasil Boil Pain Relief
Tiger Supply Inc Topical Anesthetic
Top Quality Mfg. Topical Anesthetic
Topcaine
Topcare Maximum Strength
Topical Anesthetic Banana
Topical Anesthetic Bubble Gum
Topical Anesthetic Cherry
Topical Anesthetic Mint
Topical Anesthetic Pina Colada
Topical Anesthetic Raspberry
Topical Anesthetic Strawberry
UNII-U3RSY48JW5
Ultracare Anesthetic Bubble Gum
Ultracare Anesthetic Butter Rum
Ultracare Anesthetic Creme de Menthe
Ultracare Anesthetic Pina Colada
Ultracare Anesthetic Walterberry
WLN: ZR DVO2
Walgreens Baby Teething
Walgreens Intense Toothache
Walgreens Maximum Strength
Walgreens Pain Relieving For Boils
Walgreens Severe Oral Pain Reliever
Walgreens Severe Toothache Relief
Winco Foods Maximum Strength Oral Analgesic
ZINC12358719
Zilactin-b
benzocaine
ethylaminobenzoate-4
h-4-abz-oet
nchembio.182-comp4
p-(Ethoxycarbonyl)aniline
p-Aminobenzoate
p-Aminobenzoic acid
p-Aminobenzoic acid ethyl ester
p-Aminobenzoic acid, ethyl ester
p-Aminobenzoic ethyl ester
p-Carbethoxyaniline
p-Ethoxycarboxylic Aniline
p-Ethoxycarboxylic aniline
3tannic acidNutraceuticalPhase 21536

Interventional clinical trials:

idNameStatusNCT IDPhase
1Thoracoscopic Sympathectomy for BlushingCompletedNCT00225069Phase 4
2Ventricular Arrhythmias Incidence According to Sleep Apnea Syndrome in Implantable Cardioverter-Defibrillator (ICD) PatientsCompletedNCT00708786Phase 4
3Spontaneous Atrio Ventricular Conduction PreservationCompletedNCT00655213Phase 4
4Treating Acutely Agitated Patients With Asenapine Sublingual TabletsCompletedNCT01400113Phase 4
5Mode Evaluation in Sick Sinus Syndrome Trial (MODEST)RecruitingNCT00161551Phase 4
6The Use of Human Acellular Dermal Matrix to Improve Infraauricular Depressed Deformities and Frey's SyndromeCompletedNCT01414790Phase 3
7Migraine--Investigational Treatment of Migraine With Noninvasive Brain Stimulation. (tDCS- Migraine)Active, not recruitingNCT00521196Phase 2
8Identifying Predictors of Treatment Success in Painful Bladder SyndromeNot yet recruitingNCT01410461
9Immunophenotyping From Blood of Patients Suffering From Chronic Degenerating Joint Diseases and Receiving LDRTNot yet recruitingNCT02653079

Search NIH Clinical Center for Frey Syndrome


Cochrane evidence based reviews: Sweating, Gustatory

Genetic Tests for Frey Syndrome

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Anatomical Context for Frey Syndrome

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MalaCards organs/tissues related to Frey Syndrome:

33
Salivary gland, Testes, Skin

Animal Models for Frey Syndrome or affiliated genes

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MGI Mouse Phenotypes related to Frey Syndrome:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.5ATP2A2, ETS2, NF1
2MP:00107718.2ATP2A2, ETS2, NF1

Publications for Frey Syndrome

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Articles related to Frey Syndrome:

(show top 50)    (show all 64)
idTitleAuthorsYear
1
Paraumbilical fat graft for the correction of contour deformity following parotidectomy and prevention of Frey syndrome. (26439758)
2015
2
Treatment of postparotidectomy Frey syndrome with the interposition of temporalis fascia and sternocleidomastoid flaps. (25747175)
2015
3
Is it food allergy or frey syndrome? (25609345)
2015
4
Prevention of Frey syndrome with superficial temporal fascia interpositioning: a retrospective study. (24461587)
2014
5
Prevention of Frey Syndrome With Temporal Fascia Flap in Parotidectomy. (25180948)
2014
6
The sternocleidomastoid muscle flap for the prevention of Frey syndrome and cosmetic deformity following parotidectomy: A systematic review and meta-analysis. (23599790)
2013
7
Dermofat graft after superficial parotidectomy to prevent Frey syndrome and depressed deformity. (23851784)
2013
8
Pediatric auriculotemporal nerve (Frey) syndrome. (22908140)
2013
9
Graft for prevention of Frey syndrome after parotidectomy: a systematic review and meta-analysis of randomized controlled trials. (22884117)
2013
10
Facial nerve paralysis and frey syndrome in an infant following removal of an internal mandibular distraction device. (23714921)
2013
11
Systematic evaluation on the use of acellular dermis matrix graft in prevention Frey syndrome after parotid neoplasm surgery. (24036719)
2013
12
Two-stage surgical approach with dermofat graft and lipofilling for the treatment of established Frey syndrome and facial depression deformity. (22801164)
2012
13
Fat injections for the management of post-parotidectomy Frey syndrome: a technical note. (21458286)
2012
14
Delayed Frey syndrome after closed treatment of condylar fracture. (22801163)
2012
15
Frey syndrome in a patient with facial melanoma: auriculotemporal syndrome presenting with gustatory sweating following wide local excision, sentinel node biopsy, and superficial parotidectomy. (22798976)
2012
16
AlloDerm implants for prevention of Frey syndrome after parotidectomy: a systematic review and meta-analysis. (22266670)
2012
17
Frey syndrome in children: a nonallergic cause of facial erythema triggered by food. (22812203)
2012
18
Sternomastoid fascial turnover flap for Frey syndrome: An unusual case. (20869929)
2011
19
Frey syndrome-an underreported complication to closed treatment of mandibular condyle fracture? Case report and literature review. (21496996)
2011
20
The buccal fat: a convenient and effective autologous option to prevent Frey syndrome and for facial contouring following parotidectomy. (21285821)
2011
21
Dermofat graft after superficial parotidectomy via a modified face-lift incision to prevent Frey syndrome and depressed deformity. (21558897)
2011
22
Frey syndrome in neurofibromatosis 1. (22698902)
2011
23
Facelift approach in benign parotid surgery, Frey syndrome, and total superficial parotidectomy. (21939813)
2011
24
Two rare causes of frey syndrome. (23139585)
2010
25
An unusual cause of Frey syndrome. (18804316)
2009
26
Management of Frey syndrome using botulinum neurotoxin: a case report. (19900355)
2009
27
Marathon of eponyms: 6 Frey syndrome (Gustatory sweating). (19824940)
2009
28
Repeated botulinum toxin type A injections to treat patients with Frey syndrome. (19289708)
2009
29
Management of Frey syndrome. (17230557)
2007
30
A review of the surgical and medical treatment of Frey syndrome. (17060744)
2006
31
Gustatory sweating: Frey syndrome. (16344505)
2005
32
Frey syndrome. A proposal for evaluating severity. (15006622)
2004
33
Use of AlloDerm implant to prevent frey syndrome after parotidectomy. (12533152)
2003
34
Botulinum toxin A in the treatment of patients with Frey syndrome. (11851676)
2002
35
Frey syndrome--delayed clinical onset: a case report. (12324790)
2002
36
Treatment of Frey syndrome with botulinum toxin type F. (11255487)
2001
37
What syndrome is this? Auriculotemporal nerve (Frey) syndrome. (11085676)
2000
38
The fallacy of preventing Frey syndrome during parotidectomy. (10772317)
2000
39
Parotid surgery and Frey syndrome. (10979140)
2000
40
Frey syndrome treatment with botulinum toxin. (10828793)
2000
41
Frey syndrome: treatment with type A botulinum toxin. (11042557)
2000
42
Auriculotemporal (Frey) syndrome in late childhood: an unusual variant presenting as gustatory flushing mimicking food allergy. (10792802)
2000
43
Frey syndrome before Frey: the correct history. (10499057)
1999
44
Recurrent gustatory sweating (Frey syndrome) after intracutaneous injection of botulinum toxin type A: incidence, management, and outcome. (10190799)
1999
45
Frey syndrome: treatment with temporoparietal fascia flap interposition. (10406323)
1999
46
Localized facial flushing in infancy. Auriculotemporal nerve (Frey) syndrome. (9301592)
1997
47
The Frey syndrome: a simple, effective treatment. (6817270)
1982
48
The Frey syndrome: a review and double blind evaluation of the topical use of a new anticholinergic agent. (362094)
1978
49
The intratympanic correction of Frey syndrome. (4813335)
1974
50
The auriculo-temporal or Frey syndrome and tympanic neurectomy. (4295139)
1968

Variations for Frey Syndrome

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Expression for genes affiliated with Frey Syndrome

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Search GEO for disease gene expression data for Frey Syndrome.

Pathways for genes affiliated with Frey Syndrome

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Pathways related to Frey Syndrome according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.1ATP2A2, ETS2

GO Terms for genes affiliated with Frey Syndrome

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Sources for Frey Syndrome

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet