MCID: FRY001
MIFTS: 28

Frey Syndrome malady

Rare diseases, Neuronal diseases, Smell/Taste diseases categories

Summaries for Frey Syndrome

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Sources:
44NIH Rare Diseases, 48OMIM, 34MalaCards
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NIH Rare Diseases:44 Frey's syndrome is a rare neurological disorder that results from injury or surgery near the parotid glands (which manufacture saliva), damaging the facial nerve. the parotid glands are the largest salivary glands and are located on the side of the face below and in front of the ear. this syndrome is characterized by flushing or sweating on one side of the face when certain foods are consumed. the symptoms usually are mild and well tolerated by most individuals. relief from symptoms may require treatment in some cases. last updated: 5/25/2011

MalaCards: Frey Syndrome, also known as gustatory sweating, is related to cerebellopontine angle meningioma and amyloidosis. An important gene associated with Frey Syndrome is ETS2 (v-ets avian erythroblastosis virus E26 oncogene homolog 2). Affiliated tissues include salivary gland, skin and testes.

Description from OMIM:48 144100

Aliases & Classifications for Frey Syndrome

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9Disease Ontology, 44NIH Rare Diseases, 11DISEASES, 63UMLS, 48OMIM, 59SNOMED-CT, 36MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Neuronal diseases, Smell/Taste diseases


Aliases & Descriptions:

frey syndrome 9 44 11
gustatory sweating 9 44
auriculotemporal nerve syndrome 44
auriculotemporal syndrome 63
hyperhidrosis gustatory 44
gustatory hyperhidrosis 9
sweating, gustatory 63
baillarger syndrome 9
frey's syndrome 44


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Disease Ontology9 DOID:11599
OMIM48 144100
SNOMED-CT59 56046002, 238758008
MeSH36 D013547

Related Diseases for Frey Syndrome

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Frey Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 13)
idRelated DiseaseScoreTop Affiliating Genes
1cerebellopontine angle meningioma10.2
2amyloidosis10.2
3arthritis10.2
4autonomic neuropathy10.2
5meningioma10.2
6neuropathy10.2
7rheumatoid arthritis10.2
8salivary gland disease10.2
9amyloidosis, secondary10.2
10neurofibromatosis10.1
11food allergy10.1
12melanoma10.1
13blindness10.1

Graphical network of diseases related to Frey Syndrome:



Diseases related to frey syndrome

Symptoms for Frey Syndrome

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48OMIM
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Clinical features from OMIM:

144100

Drugs & Therapeutics for Frey Syndrome

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Frey Syndrome

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Anatomical Context for Frey Syndrome

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34MalaCards
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MalaCards organs/tissues related to Frey Syndrome:

34
Salivary gland, Skin, Testes

Animal Models for Frey Syndrome or affiliated genes

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Publications for Frey Syndrome

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Sources:
53PubMed
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Articles related to Frey Syndrome:

(show top 50)    (show all 57)
idTitleAuthorsYear
1
The sternocleidomastoid muscle flap for the prevention of Frey syndrome and cosmetic deformity following parotidectomy: A systematic review and meta-analysis. (23599790)
2013
2
Dermofat graft after superficial parotidectomy to prevent Frey syndrome and depressed deformity. (23851784)
2013
3
Pediatric auriculotemporal nerve (Frey) syndrome. (22908140)
2013
4
Graft for prevention of Frey syndrome after parotidectomy: a systematic review and meta-analysis of randomized controlled trials. (22884117)
2013
5
Facial nerve paralysis and frey syndrome in an infant following removal of an internal mandibular distraction device. (23714921)
2013
6
Systematic evaluation on the use of acellular dermis matrix graft in prevention Frey syndrome after parotid neoplasm surgery. (24036719)
2013
7
Two-stage surgical approach with dermofat graft and lipofilling for the treatment of established Frey syndrome and facial depression deformity. (22801164)
2012
8
Fat injections for the management of post-parotidectomy Frey syndrome: a technical note. (21458286)
2012
9
Delayed Frey syndrome after closed treatment of condylar fracture. (22801163)
2012
10
Frey syndrome in a patient with facial melanoma: auriculotemporal syndrome presenting with gustatory sweating following wide local excision, sentinel node biopsy, and superficial parotidectomy. (22798976)
2012
11
AlloDerm implants for prevention of Frey syndrome after parotidectomy: a systematic review and meta-analysis. (22266670)
2012
12
Frey syndrome in children: a nonallergic cause of facial erythema triggered by food. (22812203)
2012
13
Sternomastoid fascial turnover flap for Frey syndrome: An unusual case. (20869929)
2011
14
Frey syndrome-an underreported complication to closed treatment of mandibular condyle fracture? Case report and literature review. (21496996)
2011
15
The buccal fat: a convenient and effective autologous option to prevent Frey syndrome and for facial contouring following parotidectomy. (21285821)
2011
16
Dermofat graft after superficial parotidectomy via a modified face-lift incision to prevent Frey syndrome and depressed deformity. (21558897)
2011
17
Frey syndrome in neurofibromatosis 1. (22698902)
2011
18
Facelift approach in benign parotid surgery, Frey syndrome, and total superficial parotidectomy. (21939813)
2011
19
Two rare causes of frey syndrome. (23139585)
2010
20
An unusual cause of Frey syndrome. (18804316)
2009
21
Management of Frey syndrome using botulinum neurotoxin: a case report. (19900355)
2009
22
Marathon of eponyms: 6 Frey syndrome (Gustatory sweating). (19824940)
2009
23
Repeated botulinum toxin type A injections to treat patients with Frey syndrome. (19289708)
2009
24
Management of Frey syndrome. (17230557)
2007
25
Prevention of Frey syndrome in parotid gland surgery. (17963668)
2007
26
A review of the surgical and medical treatment of Frey syndrome. (17060744)
2006
27
Gustatory sweating: Frey syndrome. (16344505)
2005
28
Frey syndrome. A proposal for evaluating severity. (15006622)
2004
29
Sternocleidomastoid muscle flap preventing Frey syndrome following parotidectomy. (15022023)
2004
30
Use of AlloDerm implant to prevent frey syndrome after parotidectomy. (12533152)
2003
31
Botulinum toxin A in the treatment of patients with Frey syndrome. (11851676)
2002
32
Frey syndrome--delayed clinical onset: a case report. (12324790)
2002
33
Treatment of Frey syndrome with botulinum toxin type F. (11255487)
2001
34
What syndrome is this? Auriculotemporal nerve (Frey) syndrome. (11085676)
2000
35
The fallacy of preventing Frey syndrome during parotidectomy. (10772317)
2000
36
Parotid surgery and Frey syndrome. (10979140)
2000
37
Frey syndrome treatment with botulinum toxin. (10828793)
2000
38
Frey syndrome: treatment with type A botulinum toxin. (11042557)
2000
39
Auriculotemporal (Frey) syndrome in late childhood: an unusual variant presenting as gustatory flushing mimicking food allergy. (10792802)
2000
40
Frey syndrome before Frey: the correct history. (10499057)
1999
41
Recurrent gustatory sweating (Frey syndrome) after intracutaneous injection of botulinum toxin type A: incidence, management, and outcome. (10190799)
1999
42
Frey syndrome: treatment with temporoparietal fascia flap interposition. (10406323)
1999
43
An alternative treatment for Frey syndrome. (9950578)
1999
44
Atypical Frey syndrome as a complication of Obwegeser osteotomy. (10029768)
1998
45
Localized facial flushing in infancy. Auriculotemporal nerve (Frey) syndrome. (9301592)
1997
46
The Frey syndrome: a simple, effective treatment. (6817270)
1982
47
The Frey syndrome: a review and double blind evaluation of the topical use of a new anticholinergic agent. (362094)
1978
48
The intratympanic correction of Frey syndrome. (4813335)
1974
49
The auriculo-temporal or Frey syndrome and tympanic neurectomy. (4295139)
1968
50
The auriculotemporal (Frey) syndrome occurring after parotid surgery. (13778730)
1960

Variations for Frey Syndrome

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Expression for genes affiliated with Frey Syndrome

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Frey Syndrome

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Pathways for genes affiliated with Frey Syndrome

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Compounds for genes affiliated with Frey Syndrome

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GO Terms for genes affiliated with Frey Syndrome

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Products for genes affiliated with Frey Syndrome

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  • Antibodies
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Sources for Frey Syndrome

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet