MCID: FRY001
MIFTS: 32

Frey Syndrome malady

Categories: Rare diseases, Neuronal diseases, Smell/Taste diseases

Aliases & Classifications for Frey Syndrome

About this section

Aliases & Descriptions for Frey Syndrome:

Name: Frey Syndrome 10 45 12
Sweating, Gustatory 36 65
Gustatory Sweating 10 45
Auriculotemporal Nerve Syndrome 45
Auriculotemporal Syndrome 65
 
Gustatory Hyperhidrosis 10
Hyperhidrosis Gustatory 45
Baillarger Syndrome 10
Frey's Syndrome 45

Characteristics:



Classifications:



External Ids:

Disease Ontology10 DOID:11599
SNOMED-CT59 238758008, 56046002
MeSH36 D013547
UMLS65 C0038994, C0162473

Summaries for Frey Syndrome

About this section
NIH Rare Diseases:45 Frey's syndrome is a rare neurological disorder that results from injury or surgery near the parotid glands (which manufacture saliva), damaging the facial nerve. the parotid glands are the largest salivary glands and are located on the side of the face below and in front of the ear. this syndrome is characterized by flushing or sweating on one side of the face when certain foods are consumed. the symptoms usually are mild and well tolerated by most individuals. relief from symptoms may require treatment in some cases. last updated: 5/25/2011

MalaCards based summary: Frey Syndrome, also known as sweating, gustatory, is related to hepatocellular carcinoma and breast cancer, and has symptoms including hyperhidrosis An important gene associated with Frey Syndrome is ATP2A2 (ATPase Sarcoplasmic/Endoplasmic Reticulum Ca2+ Transporting 2), and among its related pathways are Myometrial Relaxation and Contraction Pathways and Ras signaling pathway. Affiliated tissues include salivary gland, brain and heart, and related mouse phenotypes are tumorigenesis and integument.

Related Diseases for Frey Syndrome

About this section

Graphical network of the top 20 diseases related to Frey Syndrome:



Diseases related to frey syndrome

Symptoms for Frey Syndrome

About this section

HPO human phenotypes related to Frey Syndrome:

id Description Frequency HPO Source Accession
1 hyperhidrosis HP:0000975

Drugs & Therapeutics for Frey Syndrome

About this section

Drugs for Frey Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
AsenapineapprovedPhase 45385650-56-2, 65576-45-63001386, 11954293
Synonyms:
135882-95-0
1H-Dibenz[2,3:6,7]oxepino[4,5-c]pyrrole, 5-chloro-2,3,3a,12b-tetrahydro-2-met
5-chloro-2,3,3a,12b-tetrahydro-2-methyl-1H-dibenz(2,3-6,7)oxepino(4,5-c)pyrrole
65576-45-6
AC1L4SHR
Asenapi
Asenapine
Asenapine Maleate
Asenapine [INN:BAN]
CHEMBL504548
 
CID163091
EINECS 265-829-4
I14-8821
Org 5222
Org-5222
PDSP1_001600
PDSP2_001584
Saphris
UNII-JKZ19V908O
[13C,2H3]-Asenipine
trans-5-Chloro-2,3,3a,12b-tetrahydro-2-methyl-1H-dibenz(2,3:6,7)oxepino(4,5-c)pyrrole
2Tranquilizing AgentsPhase 43597
3Psychotropic DrugsPhase 45501
4Contraceptives, OralPhase 43734
5Antipsychotic AgentsPhase 42130
6Central Nervous System DepressantsPhase 410016
7
BenzocaineapprovedPhase 216841994-09-7, 94-09-72337
Synonyms:
(p-(Ethoxycarbonyl)phenylamine
06952_FLUKA
112909_ALDRICH
112909_SIAL
1333-08-0
20/20 Topical Anesthetic
23239-88-5
23239-88-5 (hydrochloride)
4 Aminobenzoic Acid Ethyl Ester
4-(Ethoxycarbonyl)aniline
4-(Ethoxycarbonyl)phenylamine
4-14-00-01129 (Beilstein Handbook Reference)
4-Aminobenzoate
4-Aminobenzoic acid
4-Aminobenzoic acid ethyl ester
4-Aminobenzoic acid, ethyl ester
4-Carbethoxyaniline
4-amino-benzoic acid ethyl ester
4-aminobenzoic acid ethyl ester
71123-91-6
94-09-7
94-09-7 (Parent)
A0271
AB00051923
AC1L1DGC
AC1Q341A
AC1Q64JE
AE-562/40377256
AI3-02081
AKOS000119763
AR-1H9065
Acetate, Benzocaine
Aethoform
Aethylium paraminobenzoicum
Alcohol Prep Pads
Allegenal-m
Alpha-caine Topical Anesthetic
Amben ethyl ester
Americaine
Anaesthan-syngala
Anaesthesin
Anaesthesinum
Anaesthin
Anbesol Jr
Anbesol Maximum Strength
Anbesol Regular Strength
Anestenka
Anestezin
Anestezin [Russian]
Anesthesin
Anesthesine
Anesthetic
Anesthone
Atopalm Oral Pain Relief
BB_SC-0019
BPBio1_001017
BRD-K75466013-001-05-2
BRN 0638434
BSPBio_000923
BSPBio_001908
Baby Anbesol
Baby Anestenka
Baby Sensigel
Baby Sensigel Night Time Formula
Baby Teething Oral Pain Reliever
Bactimicina For Sore Throat
Bencocaine Topical Anesthetic
Bensokain
Benz O Sthetic
Benzoak
Benzocaina
Benzocaina [INN-Spanish]
Benzocaine
Benzocaine (USP/INN)
Benzocaine Acetate
Benzocaine Formate
Benzocaine Hydrobromide
Benzocaine Hydrochloride
Benzocaine Methanesulfonate
Benzocaine [INN:BAN]
Benzocainum
Benzocainum [INN-Latin]
Benzodent
Benzoic acid, 4-amino-, ethyl ester
Benzoic acid, 4-amino-, ethyl ester, hydrochloride
Benzoic acid, amino-, ethyl ester
Benzoic acid, p-amino-, ethyl ester
Boil Ease
Boy Butter Desensitizing Lubricant
Boy Butter Extreme Desensitizing Lubricant
Boy Butter Extreme H2O Desensitizing Lubricant
Brace Relief
Budpak Baby Teething Oral Pain Reliever
Budpak Oral Maximum Strength
C07527
CAS-94-09-7
CHEBI:116735
CHEMBL278172
CID2337
Carmex Cold Sore Treatment External Analgesic
Caswell No. 430A
Cepacol Fizzlers
Cepacol Sensations Hydra
Cepacol Sensations Sore Throat Hydra citrus splash
Cepacol Sensations Warming
Certus Sting Relief Prep Pad
Chloraseptic
Chloraseptic Warming Sore Throat
Colgate Orabase
Comfortcaine Topical Anesthetic
Cvs Fast Acting Baby Teething
Cvs Maximum Strength
Cvs Maximum Strength Boil Relief
Cvs Oral Anesthetic
Cvs Pharmacy Instant Toothache
Cvs Pharmacy Maximum Strength
Cvs Pharmacy Mouth Sore Gel
Cvs Pharmacy Nighttime Oral Pain Relief
D001566
D00552
DB01086
Dental Relief
Dentek Instant Pain Relief Maximum Strength
Dermoplast
Diet Ayds
DivK1c_000932
Dollar General Toothache Relief
Dukal Sting Relief Pad
E1501_SIGMA
EINECS 202-303-5
EPA Pesticide Chemical Code 097001
ETHYL-P-AMINOBENZOATE
Ethoform
Ethoforme
Ethyl 4-aminobenzoate
Ethyl 4-aminobenzoate hydrochloride
Ethyl 4-aminobenzoic acid
Ethyl Aminobenzoate
Ethyl PABA
Ethyl aminobenzoate
Ethyl aminobenzoate (JP15)
Ethyl aminobenzoate (VAN)
Ethyl aminobenzoic acid
Ethyl p-Aminobenzoate
Ethyl p-Aminophenylcarboxylate
Ethyl p-aminobenzenecarboxylate
Ethyl p-aminobenzoate
Ethyl p-aminobenzoic acid
Ethyl p-aminophenylcarboxylate
Ethylester kyseliny p-aminobenzoove
Ethylester kyseliny p-aminobenzoove [Czech]
Ethylis aminobenzoas
Finafta Baby
Finafta MultiOral
Formate, Benzocaine
Gelato Topical Anesthetic
Good Neighbor Pain Relief
Goodsense Oral Pain Relief
Gps Topical Anesthetic
Gumnumb Topical Anesthetic
HMS1570O05
HMS1920G09
HMS2091M11
HMS502O14
HSDB 7225
Heb Severe Toothache
Herbasoul Male Genital Desensitizer Cream
 
Hurricaine
Hurricaine Topical Anesthetic
Hurricaine Topical Anesthetic Gel
Hurricaine Topical Anesthetic Liquid
Hydrobromide, Benzocaine
Hydrochloride, Benzocaine
I05-0204
IDI1_000932
Identhesin
Insect Bite Relief
Instant Toothache Pain Relief
Intense Cvs Intense Toothache
Iodent Maximum Strength Oral Analgesic
Ismile Topical Anesthetic
Jianze Sting Relief Pads
KBio1_000932
KBio2_000474
KBio2_003042
KBio2_005610
KBio3_001408
KBioGR_000658
KBioSS_000474
Kank-a Mouth Pain
Keloform
Kmart Smart Sense
Kroger Toothache Pain Relief
LS-35847
Leader Oral Analgesic
Little Colds Sore Throat Relief Melt Aways
MLS001331704
MLS002153970
Makesense Junior Pain Relief
Makesense Pain Relief
Male Desensitizer Pleasure Balm
Mandelay Male Genital Desensitizer
Mark 3
Methanesulfonate, Benzocaine
MolPort-000-871-526
Mouth Sore Medication
Mouth Sore Relief Applicator
Mouth Sore Relief Professional Strength
My Fair Baby Instant Pain Relief
NCGC00016352-01
NCGC00094598-01
NCGC00094598-02
NINDS_000932
NSC 122792
NSC 41531
NSC41531
NSC4688
Nene Dente
Norcain
Norcaine
Norcainum
Opahl
Opahl Dye Free
Oprea1_750694
Oprea1_827402
Ora-jel
Orabase-B
Orajel For All Mouth Sores Maximum Strength
Orajel For Cold Sores
Orajel For Toothache Maximum Strength
Orajel Instant Pain Relief Maximum Strength
Orajel Instant Pain Relief Regular Strength
Orajel Instant Relief For Teething Pain
Orajel Instant Relief For Teething Pain Cooling Cucumber
Orajel Instant Relief For Teething Pain Daytime Nighttime Twin Pack
Orajel Instant Relief For Teething Pain Longer Lasting
Orajel Maximum Strength
Orajel Nighttime Instant Relief For Teething Pain Longer Lasting Extra Strength
Orajel Severe Toothache Maximum Strength Fast-Acting Formula
Oral Analgesic Maximum Strength
Oral B Instant Pain Relief
Oral Gel Maximum Strength
Oral Pain Relief Anesthetic Anesthetic
Oral Pain Reliever
Oralabs Cold Sore Treatment
Orthesin
Otocain
Outgro
Pac-dent Top Gel
Pain Relief
Pain Relief Alcohol Swabs
Parathesin
Parathesin (TN)
Parathesine
Physicians Care Sting Relief Pad
Pleasure Balm Kama Sutra
Preboost
Prestwick0_000712
Prestwick1_000712
Prestwick2_000712
Prestwick3_000712
Prestwick_991
Purelife Topical Anesthetic
Quality Choice Maximum Strength Oral Pain Relieving
Red Cross Oral Pain Relief
Rexall Maximum Strength
Rite Aid Baby Care
Rite Aid Liquid Anesthetic Oral Pain Relief
Rite Aid Maximum Strength
Rite Aid Oral Pain Reliever
Rite Aid Professional Strength
SMR000059025
SPBio_000134
SPBio_002844
SPECTRUM1500139
STK043620
Sally Hansen Ouch-relief Numbing Wipes
Sally Hansen Ouch-relief Wax Kit
Sally Hansen Ouch-relief Wax Strip Kit
Sensigel
Severe Oral Pain Reliever
Sheffield Baby Teething Gel
Sheffield Pain Relief
Shunga Male Genital Desensitizer
Slim Mint Gum
Solarcaine
Solu H
Spectrum2_000117
Spectrum3_000314
Spectrum4_000249
Spectrum5_000860
Spectrum_000074
Sting Relief Medicated Pad
Sting Relief Pads
Tanac
Terrasil Boil Pain Relief
Tiger Supply Inc Topical Anesthetic
Top Quality Mfg. Topical Anesthetic
Topcaine
Topcare Maximum Strength
Topical Anesthetic Banana
Topical Anesthetic Bubble Gum
Topical Anesthetic Cherry
Topical Anesthetic Mint
Topical Anesthetic Pina Colada
Topical Anesthetic Raspberry
Topical Anesthetic Strawberry
UNII-U3RSY48JW5
Ultracare Anesthetic Bubble Gum
Ultracare Anesthetic Butter Rum
Ultracare Anesthetic Creme de Menthe
Ultracare Anesthetic Pina Colada
Ultracare Anesthetic Walterberry
WLN: ZR DVO2
Walgreens Baby Teething
Walgreens Intense Toothache
Walgreens Maximum Strength
Walgreens Pain Relieving For Boils
Walgreens Severe Oral Pain Reliever
Walgreens Severe Toothache Relief
Winco Foods Maximum Strength Oral Analgesic
ZINC12358719
Zilactin-b
benzocaine
ethylaminobenzoate-4
h-4-abz-oet
nchembio.182-comp4
p-(Ethoxycarbonyl)aniline
p-Aminobenzoate
p-Aminobenzoic acid
p-Aminobenzoic acid ethyl ester
p-Aminobenzoic acid, ethyl ester
p-Aminobenzoic ethyl ester
p-Carbethoxyaniline
p-Ethoxycarboxylic Aniline
p-Ethoxycarboxylic aniline
8tannic acidNutraceuticalPhase 21684

Interventional clinical trials:

idNameStatusNCT IDPhase
1Thoracoscopic Sympathectomy for BlushingCompletedNCT00225069Phase 4
2Ventricular Arrhythmias Incidence According to Sleep Apnea Syndrome in Implantable Cardioverter-Defibrillator (ICD) PatientsCompletedNCT00708786Phase 4
3Spontaneous Atrio Ventricular Conduction PreservationCompletedNCT00655213Phase 4
4Treating Acutely Agitated Patients With Asenapine Sublingual TabletsCompletedNCT01400113Phase 4
5Mode Evaluation in Sick Sinus Syndrome Trial (MODEST)RecruitingNCT00161551Phase 4
6The Use of Human Acellular Dermal Matrix to Improve Infraauricular Depressed Deformities and Frey's SyndromeCompletedNCT01414790Phase 3
7Migraine--Investigational Treatment of Migraine With Noninvasive Brain Stimulation. (tDCS- Migraine)Active, not recruitingNCT00521196Phase 2
8Direct Current Stimulation for Treatment of FibromyalgiaRecruitingNCT02704611
9Identifying Predictors of Treatment Success in Painful Bladder SyndromeNot yet recruitingNCT01410461
10Immunophenotyping From Blood of Patients Suffering From Chronic Degenerating Joint Diseases and Receiving LDRTNot yet recruitingNCT02653079

Search NIH Clinical Center for Frey Syndrome


Cochrane evidence based reviews: sweating, gustatory

Genetic Tests for Frey Syndrome

About this section

Anatomical Context for Frey Syndrome

About this section

MalaCards organs/tissues related to Frey Syndrome:

33
Salivary gland, Brain, Heart, Liver, Breast, Pituitary, Testis

Animal Models for Frey Syndrome or affiliated genes

About this section

MGI Mouse Phenotypes related to Frey Syndrome:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.6ATP2A2, ETS2, NF1
2MP:00107718.5ATP2A2, ETS2, NF1
3MP:00053858.5ATP2A2, ETS2, NF1

Publications for Frey Syndrome

About this section

Articles related to Frey Syndrome:

(show top 50)    (show all 64)
idTitleAuthorsYear
1
Peroneal neuropathy misdiagnosed as L5 radiculopathy: a case report. (23618508)
2013
2
An assessment of radiologically inserted transoral and transgastric gastroduodenal stents to treat malignant gastric outlet obstruction. (23456310)
2013
3
De-politicizing youth suicide prevention. (24400254)
2013
4
Arteriovenous malformation associated with cyst in a child: Case report and review of literature. (24082931)
2013
5
Multiple tenotomies after Ponseti method for management of severe rigid clubfoot. (22112303)
2012
6
Superficial siderosis of the central nervous system manifested with seizures. (20006512)
2010
7
Tumour cell migration in adamantinomatous craniopharyngiomas is promoted by activated Wnt-signalling. (20131060)
2010
8
Angiotensin-converting-enzyme inhibitors versus steroids as first-line drug treatment in Duchenne muscular dystrophy. (20636389)
2010
9
Podoplanin, a novel marker for seminoma: A comparison study evaluating immunohistochemical expression of podoplanin and OCT3/4. (20850695)
2010
10
A case of SAPHO syndrome with destructive spondylodiscitis suspicious of tuberculous spondylitis. (19830381)
2010
11
Genetic background modifies neurodegeneration and neuroinflammation driven by misfolded human tau protein in rat model of tauopathy: implication for immunomodulatory approach to Alzheimer's disease. (20937161)
2010
12
Association of the dystrobrevin binding protein 1 gene (DTNBP1) in a bipolar case-control study (BACCS). (19089808)
2009
13
The effect of topical amphotericin B on inflammatory markers in patients with chronic rhinosinusitis: a multicenter randomized controlled study. (19160404)
2009
14
Polymorphism in glutathione-S-transferases: a risk factor in alcoholic liver cirrhosis. (19157724)
2009
15
Electrocardiographic abnormalities in young athletes with mitral valve prolapse. (19455568)
2009
16
Catalysis-associated conformational changes revealed by human CD38 complexed with a non-hydrolyzable substrate analog. (17591784)
2007
17
Characterization of a SEPT9 interacting protein, SEPT14, a novel testis-specific septin. (17922164)
2007
18
Development of in vitro methods to predict induction of CYP1A2 and CYP3A4 in humans. (18052847)
2007
19
Flinders Island spotted fever rickettsioses caused by "marmionii" strain of Rickettsia honei, Eastern Australia. (17553271)
2007
20
Crystal structure of uroporphyrinogen decarboxylase from Bacillus subtilis. (17122346)
2007
21
Plasma levels of receptor activator of nuclear factor-kappaB ligand and osteoprotegerin in patients with neuroblastoma. (16450378)
2006
22
The expressions of cyclooxygenase-2 (Cox-2),VEGF in oral squamous cell carcinoma and precancerous lesions and their significances]. (15886845)
2005
23
Detection of Parkin (PARK2) and DJ1 (PARK7) mutations in early-onset Parkinson disease: Parkin mutation frequency depends on ethnic origin of patients. (15108293)
2004
24
CSF and serum immune parameters in Sydenham's chorea: evidence of an autoimmune syndrome? (12620654)
2003
25
Allelic variants interaction of dopamine receptor D4 polymorphism correlate with personality traits in young Korean female population. (12627471)
2003
26
MHC class II engagement by its ligand LAG-3 (CD223) leads to a distinct pattern of chemokine and chemokine receptor expression by human dendritic cells. (12547595)
2003
27
Lipoatrophic diabetes in Irs1(-/-)/Irs3(-/-) double knockout mice. (12502742)
2002
28
Prevention of diabetes-induced albuminuria in transgenic rats overexpressing human aldose reductase. (12166624)
2002
29
BRCA2 function in DNA binding and recombination from a BRCA2-DSS1- ssDNA structure. (12228710)
2002
30
Presence of claudins mRNA in the brain. Selective modulation of expression by kindling epilepsy. (12225881)
2002
31
Antitumor effect of adenovirus-mediated Bax gene transfer on p53-sensitive and p53-resistant cancer lines. (10728665)
2000
32
Study of the binding of 114mIn radiotracer to human serum components by ultrafiltration and chromatography. (11220595)
2000
33
Carbonic anhydrase activators: synthesis of high affinity isozymes I, II and IV activators, derivatives of 4-(arylsulfonylureido-amino acyl)ethyl-1H-imidazole. (11030087)
2000
34
The adsorptive properties of hydroxyapatite to albumin, dextran and lipids. (10572620)
1999
35
Ectopic ascariasis: an unusual case of pyopneumothorax. (9775571)
1998
36
Use of the polymerase chain reaction in the diagnosis of herpes simplex encephalitis: a decision analysis model. (9809689)
1998
37
The Birmingham pituitary database: auditing the outcome of the treatment of acromegaly. (8548933)
1995
38
Musculoskeletal disorders in juvenile onset mixed connective tissue disease. (7791176)
1995
39
A novel gene encoding a B-box protein within the BRCA1 region at 17q21.1. (8069304)
1994
40
Analytical problems in detecting rapid insulin secretory pulses in normal humans. (8447390)
1993
41
Developmental dyscalculia and medical assessment. (7681863)
1993
42
Reconstitution of functional water channels in liposomes containing purified red cell CHIP28 protein. (1510932)
1992
43
Human chromosome 16 physical map: mapping of somatic cell hybrids using multiplex PCR deletion analysis of sequence tagged sites. (1916811)
1991
44
Histamine, 5-HT & hyaluronidase in the venom of the scorpion Lychas laevifrons (Pock). (1703125)
1990
45
Spatial distribution of "tissue-specific" antigens in the developing human heart and skeletal muscle. I. An immunohistochemical analysis of creatine kinase isoenzyme expression patterns. (2240609)
1990
46
Rhinosporidiosis in Kuwait. (3738987)
1986
47
Failure of metronidazole treatment in Ethiopian mucocutaneous leishmaniasis. (708614)
1978
48
Acute maxillary sinusitis caused by a guttapercha point. (269850)
1977
49
Significance of serum fungal inhibitory factor in dermatophytosis. (4210549)
1974
50
Two entities in angiolipoma. A study of 459 cases of lipoma with review of literature on infiltrating angiolipoma. (4855281)
1974

Variations for Frey Syndrome

About this section

Expression for genes affiliated with Frey Syndrome

About this section
Search GEO for disease gene expression data for Frey Syndrome.

Pathways for genes affiliated with Frey Syndrome

About this section

Pathways related to Frey Syndrome according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
9.3ATP2A2, ETS2
2
Show member pathways
9.1ETS2, NF1

GO Terms for genes affiliated with Frey Syndrome

About this section

Sources for Frey Syndrome

About this section
2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet