MCID: FRY001
MIFTS: 35

Frey Syndrome malady

Categories: Rare diseases, Neuronal diseases, Smell/Taste diseases

Aliases & Classifications for Frey Syndrome

Aliases & Descriptions for Frey Syndrome:

Name: Frey Syndrome 12 50 14
Sweating, Gustatory 42 69
Gustatory Sweating 12 50
Auriculotemporal Nerve Syndrome 50
Auriculotemporal Syndrome 69
Gustatory Hyperhidrosis 12
Hyperhidrosis Gustatory 50
Baillarger Syndrome 12
Frey's Syndrome 50

Characteristics:

HPO:

32
frey syndrome:
Inheritance autosomal dominant inheritance


Classifications:



External Ids:

Disease Ontology 12 DOID:11599
MeSH 42 D013547
SNOMED-CT 64 238758008 56046002
UMLS 69 C0038994

Summaries for Frey Syndrome

NIH Rare Diseases : 50 frey's syndrome is a rare neurological disorder that may result from injury or surgery near the parotid glands (which manufacture saliva), damaging the facial nerve. the parotid glands are the largest salivary glands and are located on the side of the face below and in front of the ear. this syndrome is characterized by flushing or sweating on one side of the face when certain foods are consumed. the symptoms are usually mild and well tolerated. in cases where symptoms are more extreme or accompanied by significant disruption of daily activities, drug therapy or surgery may be utilized. last updated: 9/25/2016

MalaCards based summary : Frey Syndrome, also known as sweating, gustatory, is related to folic acid deficiency anemia and american histoplasmosis, and has symptoms including hyperhidrosis An important gene associated with Frey Syndrome is CANX (Calnexin), and among its related pathways/superpathways is FOXA2 and FOXA3 transcription factor networks. The drugs Asenapine and Ticagrelor have been mentioned in the context of this disorder. Affiliated tissues include salivary gland, testes and skin, and related phenotype is neoplasm.

Related Diseases for Frey Syndrome

Graphical network of the top 20 diseases related to Frey Syndrome:



Diseases related to Frey Syndrome

Symptoms & Phenotypes for Frey Syndrome

Human phenotypes related to Frey Syndrome:

32
id Description HPO Frequency HPO Source Accession
1 hyperhidrosis 32 HP:0000975

MGI Mouse Phenotypes related to Frey Syndrome:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 8.92 ATP2A2 ETS2 HCK NF1

Drugs & Therapeutics for Frey Syndrome

Drugs for Frey Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 22)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Asenapine Approved Phase 4 85650-56-2, 65576-45-6 3001386
2
Ticagrelor Approved Phase 4 274693-27-5 9871419
3 Antipsychotic Agents Phase 4
4 Central Nervous System Depressants Phase 4
5 Psychotropic Drugs Phase 4
6 Tranquilizing Agents Phase 4
7 Neurotransmitter Agents Phase 4
8 Platelet Aggregation Inhibitors Phase 4
9 Prasugrel hydrochloride Phase 4 389574-19-0
10 Purinergic P2 Receptor Antagonists Phase 4
11 Purinergic P2Y Receptor Antagonists Phase 4
12 Vaccines Phase 1, Phase 2
13
Benzocaine Approved 1994-09-7, 94-09-7 2337
14
Aluminum hydroxide Approved 21645-51-2
15 tannic acid Approved, Nutraceutical
16 Adjuvants, Immunologic
17 Antacids
18 Antibodies
19 Anti-Ulcer Agents
20 Gastrointestinal Agents
21 HIV Antibodies
22 Immunoglobulins

Interventional clinical trials:

(show all 16)
id Name Status NCT ID Phase
1 Mode Evaluation in Sick Sinus Syndrome Trial (MODEST) Unknown status NCT00161551 Phase 4
2 Thoracoscopic Sympathectomy for Blushing Completed NCT00225069 Phase 4
3 Treating Acutely Agitated Patients With Asenapine Sublingual Tablets Completed NCT01400113 Phase 4
4 Ventricular Arrhythmias Incidence According to Sleep Apnea Syndrome in Implantable Cardioverter-Defibrillator (ICD) Patients Completed NCT00708786 Phase 4
5 Spontaneous Atrio Ventricular Conduction Preservation Completed NCT00655213 Phase 4
6 Prospective, Randomized Trial of Ticagrelor Versus Prasugrel in Patients With Acute Coronary Syndrome Recruiting NCT01944800 Phase 4
7 The Use of Human Acellular Dermal Matrix to Improve Infraauricular Depressed Deformities and Frey's Syndrome Completed NCT01414790 Phase 3
8 A Study of LIPO-5 and ALVAC-HIV (vCP1452) as Possible HIV Vaccines Completed NCT00076063 Phase 1, Phase 2
9 A Phase I-II Open Label Non-Randomized Study Using TL32711 for Patients With Acute Myelogenous Leukemia, Myelodysplastic Syndrome and Acute Lymphoblastic Leukemia Active, not recruiting NCT01486784 Phase 1, Phase 2
10 Effect of Cannabis and Endocannabinoids on HIV Neuropathic Pain Not yet recruiting NCT03099005 Phase 2
11 Safety of and Immune Response to Two HIV Vaccine Formulations (rMVA-HIV and rFPV-HIV) Alone or in Combination in HIV Uninfected Adults Completed NCT00083603 Phase 1
12 Identifying Predictors of Treatment Success in Painful Bladder Syndrome Unknown status NCT01410461
13 Migraine--Investigational Treatment of Migraine With Noninvasive Brain Stimulation. (tDCS- Migraine) Completed NCT00521196
14 The Effectiveness of Human Antibodies in Influencing an AIDS-Like Disease in Monkeys Completed NCT00031109
15 Immunophenotyping From Blood of Patients Suffering From Chronic Degenerating Joint Diseases and Receiving LDRT Recruiting NCT02653079
16 Direct Current Stimulation for Treatment of Fibromyalgia Recruiting NCT02704611

Search NIH Clinical Center for Frey Syndrome

Cochrane evidence based reviews: sweating, gustatory

Genetic Tests for Frey Syndrome

Anatomical Context for Frey Syndrome

MalaCards organs/tissues related to Frey Syndrome:

39
Salivary Gland, Testes, Skin

Publications for Frey Syndrome

Articles related to Frey Syndrome:

(show top 50) (show all 70)
id Title Authors Year
1
Parotid Branches of the Auriculotemporal Nerve: An Anatomical Study With Implications for Frey Syndrome. ( 27930465 )
2017
2
Auriculotemporal Syndrome (Frey Syndrome). ( 26902982 )
2016
3
The superficial musculoaponeurotic system flap in the prevention of Frey syndrome: A meta-analysis. ( 26915301 )
2016
4
Frey Syndrome. ( 27157448 )
2016
5
Effectiveness of platysma muscle flap in preventing Frey syndrome and depressive deformities after parotidectomy. ( 26832076 )
2016
6
Comparison of Frey Syndrome Rates Following Superficial Parotidectomy and Partial Superficial Parotidectomy for Pleomorphic Adenoma. ( 27391515 )
2016
7
Is it food allergy or frey syndrome? ( 25609345 )
2015
8
Frey syndrome: factors influencing the time to event. ( 25735534 )
2015
9
Paraumbilical fat graft for the correction of contour deformity following parotidectomy and prevention of Frey syndrome. ( 26439758 )
2015
10
Treatment of postparotidectomy Frey syndrome with the interposition of temporalis fascia and sternocleidomastoid flaps. ( 25747175 )
2015
11
Prevention of Frey syndrome with superficial temporal fascia interpositioning: a retrospective study. ( 24461587 )
2014
12
Prevention of Frey Syndrome With Temporal Fascia Flap in Parotidectomy. ( 25180948 )
2014
13
Facial nerve paralysis and frey syndrome in an infant following removal of an internal mandibular distraction device. ( 23714921 )
2013
14
Dermofat graft after superficial parotidectomy to prevent Frey syndrome and depressed deformity. ( 23851784 )
2013
15
Episodic facial sweating. Frey Syndrome. ( 23454328 )
2013
16
Pediatric auriculotemporal nerve (Frey) syndrome. ( 22908140 )
2013
17
Systematic evaluation on the use of acellular dermis matrix graft in prevention Frey syndrome after parotid neoplasm surgery. ( 24036719 )
2013
18
The sternocleidomastoid muscle flap for the prevention of Frey syndrome and cosmetic deformity following parotidectomy: A systematic review and meta-analysis. ( 23599790 )
2013
19
Graft for prevention of Frey syndrome after parotidectomy: a systematic review and meta-analysis of randomized controlled trials. ( 22884117 )
2013
20
Galvanic skin response test: a new quantitative diagnostic method for Frey syndrome. ( 23851788 )
2013
21
AlloDerm implants for prevention of Frey syndrome after parotidectomy: a systematic review and meta-analysis. ( 22266670 )
2012
22
Delayed Frey syndrome after closed treatment of condylar fracture. ( 22801163 )
2012
23
Two-stage surgical approach with dermofat graft and lipofilling for the treatment of established Frey syndrome and facial depression deformity. ( 22801164 )
2012
24
Frey syndrome in a patient with facial melanoma: auriculotemporal syndrome presenting with gustatory sweating following wide local excision, sentinel node biopsy, and superficial parotidectomy. ( 22798976 )
2012
25
Frey syndrome in children: a nonallergic cause of facial erythema triggered by food. ( 22812203 )
2012
26
Fat injections for the management of post-parotidectomy Frey syndrome: a technical note. ( 21458286 )
2012
27
Frey syndrome in neurofibromatosis 1. ( 22698902 )
2011
28
Facelift approach in benign parotid surgery, Frey syndrome, and total superficial parotidectomy. ( 21939813 )
2011
29
Dermofat graft after superficial parotidectomy via a modified face-lift incision to prevent Frey syndrome and depressed deformity. ( 21558897 )
2011
30
The buccal fat: a convenient and effective autologous option to prevent Frey syndrome and for facial contouring following parotidectomy. ( 21285821 )
2011
31
Frey syndrome-an underreported complication to closed treatment of mandibular condyle fracture? Case report and literature review. ( 21496996 )
2011
32
Sternomastoid fascial turnover flap for Frey syndrome: An unusual case. ( 20869929 )
2011
33
Ethics of Frey syndrome: ensuring that consent is truly informed. ( 20641103 )
2010
34
Two rare causes of frey syndrome. ( 23139585 )
2010
35
The buccal fat: a convenient and effective autologous option to prevent Frey syndrome and for facial contouring following parotidectomy. ( 20517094 )
2010
36
Familial auriculotemporal nerve (Frey) syndrome. ( 19706092 )
2009
37
An unusual cause of Frey syndrome. ( 18804316 )
2009
38
Management of Frey syndrome using botulinum neurotoxin: a case report. ( 19900355 )
2009
39
Repeated botulinum toxin type A injections to treat patients with Frey syndrome. ( 19289708 )
2009
40
Marathon of eponyms: 6 Frey syndrome (Gustatory sweating). ( 19824940 )
2009
41
Prevention of Frey syndrome in parotid gland surgery. ( 17963668 )
2007
42
Management of Frey syndrome. ( 17230557 )
2007
43
Frey syndrome prevalence after partial parotidectomy. ( 16917561 )
2006
44
A review of the surgical and medical treatment of Frey syndrome. ( 17060744 )
2006
45
Gustatory sweating: Frey syndrome. ( 16344505 )
2005
46
Frey syndrome. A proposal for evaluating severity. ( 15006622 )
2004
47
Sternocleidomastoid muscle flap preventing Frey syndrome following parotidectomy. ( 15022023 )
2004
48
Use of AlloDerm implant to prevent frey syndrome after parotidectomy. ( 12533152 )
2003
49
Frey syndrome--delayed clinical onset: a case report. ( 12324790 )
2002
50
Botulinum toxin A in the treatment of patients with Frey syndrome. ( 11851676 )
2002

Variations for Frey Syndrome

Expression for Frey Syndrome

Search GEO for disease gene expression data for Frey Syndrome.

Pathways for Frey Syndrome

Pathways related to Frey Syndrome according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 10.27 F2 NF1

GO Terms for Frey Syndrome

Cellular components related to Frey Syndrome according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extrinsic component of cytoplasmic side of plasma membrane GO:0031234 8.62 ATP2A2 HCK

Biological processes related to Frey Syndrome according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 mesoderm development GO:0007498 8.96 ETS2 HCK
2 negative regulation of astrocyte differentiation GO:0048712 8.62 F2 NF1

Sources for Frey Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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