MCID: FRY001
MIFTS: 29

Frey Syndrome malady

Neuronal, Smell/Taste categories

Summaries for Frey Syndrome

Sources:
43NIH Rare Diseases, 47OMIM, 33MalaCards
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NIH Rare Diseases:43 Frey's syndrome is a rare neurological disorder that results from injury or surgery near the parotid glands (which manufacture saliva), damaging the facial nerve. the parotid glands are the largest salivary glands and are located on the side of the face below and in front of the ear. this syndrome is characterized by flushing or sweating on one side of the face when certain foods are consumed. the symptoms usually are mild and well tolerated by most individuals. relief from symptoms may require treatment in some cases. last updated: 5/25/2011

MalaCards: Frey Syndrome, also known as gustatory sweating, is related to n syndrome and cerebellopontine angle meningioma. An important gene associated with Frey Syndrome is AKAP5 (A kinase (PRKA) anchor protein 5). The compounds tacrolimus and atp have been mentioned in the context of this disorder. Affiliated tissues include salivary gland and skin.

Description from OMIM:47 144100

Aliases & Classifications for Frey Syndrome

Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 61UMLS, 35MeSH, 57SNOMED-CT, 47OMIM
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal, Smell/Taste


Aliases & Descriptions:

frey syndrome 8 43 10
gustatory sweating 8 43
auriculotemporal nerve syndrome 43
auriculotemporal syndrome 61
gustatory hyperhidrosis 8
hyperhidrosis gustatory 43
sweating, gustatory 61
baillarger syndrome 8
frey's syndrome 43


External Ids:

Disease Ontology8 DOID:11599
MeSH35 D013547
SNOMED-CT57 238758008, 56046002
OMIM47 144100

Related Diseases for Frey Syndrome

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Frey Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

idRelated DiseaseScoreTop Affiliating Genes
1n syndrome10.6
2cerebellopontine angle meningioma10.2
3amyloidosis10.2
4arthritis10.2
5autonomic neuropathy10.2
6sweat gland disease10.2
7amyloid neuropathy10.2
8amyloidosis, secondary10.2
9neurofibromatosis10.1

Graphical network of diseases related to Frey Syndrome:



Diseases related to frey syndrome

Clinical Features for Frey Syndrome

Sources:
47OMIM
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Clinical features from OMIM:

144100

Drugs & Therapeutics for Frey Syndrome

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Frey Syndrome

Drug clinical trials:

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Search NIH Clinical Center for Frey Syndrome

Search CenterWatch for Frey Syndrome

Genetic Tests for Frey Syndrome

Anatomical Context for Frey Syndrome

Sources:
33MalaCards
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MalaCards organs/tissues related to Frey Syndrome:

33
Salivary gland, Skin

Animal Models for Frey Syndrome or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Frey Syndrome

Sources:
51PubMed
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Articles related to Frey Syndrome:

(show top 50)    (show all 57)
idTitleAuthorsYear
1
Dermofat graft after superficial parotidectomy to prevent Frey syndrome and depressed deformity. (23851784)
2013
2
Pediatric auriculotemporal nerve (Frey) syndrome. (22908140)
2013
3
Graft for prevention of Frey syndrome after parotidectomy: a systematic review and meta-analysis of randomized controlled trials. (22884117)
2013
4
Facial nerve paralysis and frey syndrome in an infant following removal of an internal mandibular distraction device. (23714921)
2013
5
Systematic evaluation on the use of acellular dermis matrix graft in prevention Frey syndrome after parotid neoplasm surgery. (24036719)
2013
6
Galvanic skin response test: a new quantitative diagnostic method for Frey syndrome. (23851788)
2013
7
Fat injections for the management of post-parotidectomy Frey syndrome: a technical note. (21458286)
2012
8
Delayed Frey syndrome after closed treatment of condylar fracture. (22801163)
2012
9
Frey syndrome in a patient with facial melanoma: auriculotemporal syndrome presenting with gustatory sweating following wide local excision, sentinel node biopsy, and superficial parotidectomy. (22798976)
2012
10
AlloDerm implants for prevention of Frey syndrome after parotidectomy: a systematic review and meta-analysis. (22266670)
2012
11
Frey syndrome in children: a nonallergic cause of facial erythema triggered by food. (22812203)
2012
12
Sternomastoid fascial turnover flap for Frey syndrome: An unusual case. (20869929)
2011
13
Frey syndrome-an underreported complication to closed treatment of mandibular condyle fracture? Case report and literature review. (21496996)
2011
14
The buccal fat: a convenient and effective autologous option to prevent Frey syndrome and for facial contouring following parotidectomy. (21285821)
2011
15
Dermofat graft after superficial parotidectomy via a modified face-lift incision to prevent Frey syndrome and depressed deformity. (21558897)
2011
16
Facelift approach in benign parotid surgery, Frey syndrome, and total superficial parotidectomy. (21939813)
2011
17
The buccal fat: a convenient and effective autologous option to prevent Frey syndrome and for facial contouring following parotidectomy. (20517094)
2010
18
Ethics of Frey syndrome: ensuring that consent is truly informed. (20641103)
2010
19
An unusual cause of Frey syndrome. (18804316)
2009
20
Management of Frey syndrome using botulinum neurotoxin: a case report. (19900355)
2009
21
Marathon of eponyms: 6 Frey syndrome (Gustatory sweating). (19824940)
2009
22
Repeated botulinum toxin type A injections to treat patients with Frey syndrome. (19289708)
2009
23
Familial auriculotemporal nerve (Frey) syndrome. (19706092)
2009
24
Management of Frey syndrome. (17230557)
2007
25
Prevention of Frey syndrome in parotid gland surgery. (17963668)
2007
26
A review of the surgical and medical treatment of Frey syndrome. (17060744)
2006
27
Frey syndrome prevalence after partial parotidectomy. (16917561)
2006
28
Gustatory sweating: Frey syndrome. (16344505)
2005
29
Frey syndrome. A proposal for evaluating severity. (15006622)
2004
30
Sternocleidomastoid muscle flap preventing Frey syndrome following parotidectomy. (15022023)
2004
31
Use of AlloDerm implant to prevent frey syndrome after parotidectomy. (12533152)
2003
32
Botulinum toxin A in the treatment of patients with Frey syndrome. (11851676)
2002
33
Treatment of Frey syndrome with botulinum toxin type F. (11255487)
2001
34
What syndrome is this? Auriculotemporal nerve (Frey) syndrome. (11085676)
2000
35
The fallacy of preventing Frey syndrome during parotidectomy. (10772317)
2000
36
Parotid surgery and Frey syndrome. (10979140)
2000
37
Frey syndrome treatment with botulinum toxin. (10828793)
2000
38
Frey syndrome: treatment with type A botulinum toxin. (11042557)
2000
39
Auriculotemporal (Frey) syndrome in late childhood: an unusual variant presenting as gustatory flushing mimicking food allergy. (10792802)
2000
40
Frey syndrome before Frey: the correct history. (10499057)
1999
41
Recurrent gustatory sweating (Frey syndrome) after intracutaneous injection of botulinum toxin type A: incidence, management, and outcome. (10190799)
1999
42
Frey syndrome: treatment with temporoparietal fascia flap interposition. (10406323)
1999
43
Prevention of Frey syndrome during parotidectomy. (10448728)
1999
44
Localized facial flushing in infancy. Auriculotemporal nerve (Frey) syndrome. (9301592)
1997
45
The Frey syndrome: a simple, effective treatment. (6817270)
1982
46
The Frey syndrome: a review and double blind evaluation of the topical use of a new anticholinergic agent. (362094)
1978
47
A reevaluation of the Frey syndrome following parotid surgery. (857787)
1977
48
The intratympanic correction of Frey syndrome. (4813335)
1974
49
The auriculo-temporal or Frey syndrome and tympanic neurectomy. (4295139)
1968
50
The auriculotemporal (Frey) syndrome occurring after parotid surgery. (13778730)
1960

Genetic Variations for Frey Syndrome

Expression for genes affiliated with Frey Syndrome

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Frey Syndrome

Search GEO for disease gene expression data for Frey Syndrome.

Pathways for genes affiliated with Frey Syndrome

Compounds for genes affiliated with Frey Syndrome

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 29IUPHAR
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Compounds related to Frey Syndrome according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1tacrolimus45 50 1111.3AKAP5, PDP1
2atp45 2910.1SRL, AKAP5, PDP1
3threonine458.5IKBKAP, ETS2, AKAP5, PDP1
4serine458.4PDP1, AKAP5, ETS2, IKBKAP

GO Terms for genes affiliated with Frey Syndrome

Products for genes affiliated with Frey Syndrome

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Sources for Frey Syndrome

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet