MCID: FRY001
MIFTS: 32

Frey Syndrome malady

Neuronal diseases, Smell/Taste diseases categories

Summaries for Frey Syndrome

About this section
Sources:
42NIH Rare Diseases, 46OMIM, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
NIH Rare Diseases:42 Frey's syndrome is a rare neurological disorder that results from injury or surgery near the parotid glands (which manufacture saliva), damaging the facial nerve. the parotid glands are the largest salivary glands and are located on the side of the face below and in front of the ear. this syndrome is characterized by flushing or sweating on one side of the face when certain foods are consumed. the symptoms usually are mild and well tolerated by most individuals. relief from symptoms may require treatment in some cases. last updated: 5/25/2011

MalaCards: Frey Syndrome, also known as gustatory sweating, is related to cerebellopontine angle meningioma and amyloidosis. An important gene associated with Frey Syndrome is AKAP5 (A kinase (PRKA) anchor protein 5). The compounds tacrolimus and atp have been mentioned in the context of this disorder. Affiliated tissues include salivary gland, skin and testes.

Description from OMIM:46 144100

Aliases & Classifications for Frey Syndrome

About this section
Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 60UMLS, 34MeSH, 56SNOMED-CT, 46OMIM
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases, Smell/Taste diseases


Aliases & Descriptions:

frey syndrome 8 42 10
gustatory sweating 8 42
auriculotemporal nerve syndrome 42
auriculotemporal syndrome 60
gustatory hyperhidrosis 8
hyperhidrosis gustatory 42
sweating, gustatory 60
baillarger syndrome 8
frey's syndrome 42


External Ids:

Disease Ontology8 DOID:11599
MeSH34 D013547
SNOMED-CT56 238758008, 56046002
OMIM46 144100

Related Diseases for Frey Syndrome

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Frey Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 13)
idRelated DiseaseScoreTop Affiliating Genes
1cerebellopontine angle meningioma10.1
2amyloidosis10.1
3arthritis10.1
4autonomic neuropathy10.1
5meningioma10.1
6neuropathy10.1
7rheumatoid arthritis10.1
8salivary gland disease10.1
9sweat gland disease10.1
10neurofibromatosis10.0
11facial paralysis10.0
12food allergy10.0
13melanoma10.0

Graphical network of diseases related to Frey Syndrome:



Diseases related to frey syndrome

Clinical Features for Frey Syndrome

About this section
Sources:
46OMIM
See all sources

Clinical features from OMIM:

144100

Drugs & Therapeutics for Frey Syndrome

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Frey Syndrome

Drug clinical trials:

Search ClinicalTrials for Frey Syndrome

Search NIH Clinical Center for Frey Syndrome

Search CenterWatch for Frey Syndrome

Genetic Tests for Frey Syndrome

About this section

Anatomical Context for Frey Syndrome

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Frey Syndrome:

32
Salivary gland, Skin, Testes

Animal Models for Frey Syndrome or affiliated genes

About this section

Publications for Frey Syndrome

About this section
Sources:
50PubMed
See all sources

Articles related to Frey Syndrome:

(show top 50)    (show all 57)
idTitleAuthorsYear
1
The sternocleidomastoid muscle flap for the prevention of Frey syndrome and cosmetic deformity following parotidectomy: A systematic review and meta-analysis. (23599790)
2013
2
Dermofat graft after superficial parotidectomy to prevent Frey syndrome and depressed deformity. (23851784)
2013
3
Pediatric auriculotemporal nerve (Frey) syndrome. (22908140)
2013
4
Systematic evaluation on the use of acellular dermis matrix graft in prevention Frey syndrome after parotid neoplasm surgery. (24036719)
2013
5
Galvanic skin response test: a new quantitative diagnostic method for Frey syndrome. (23851788)
2013
6
Two-stage surgical approach with dermofat graft and lipofilling for the treatment of established Frey syndrome and facial depression deformity. (22801164)
2012
7
Fat injections for the management of post-parotidectomy Frey syndrome: a technical note. (21458286)
2012
8
Delayed Frey syndrome after closed treatment of condylar fracture. (22801163)
2012
9
Frey syndrome in a patient with facial melanoma: auriculotemporal syndrome presenting with gustatory sweating following wide local excision, sentinel node biopsy, and superficial parotidectomy. (22798976)
2012
10
AlloDerm implants for prevention of Frey syndrome after parotidectomy: a systematic review and meta-analysis. (22266670)
2012
11
Frey syndrome in children: a nonallergic cause of facial erythema triggered by food. (22812203)
2012
12
Sternomastoid fascial turnover flap for Frey syndrome: An unusual case. (20869929)
2011
13
The buccal fat: a convenient and effective autologous option to prevent Frey syndrome and for facial contouring following parotidectomy. (21285821)
2011
14
Dermofat graft after superficial parotidectomy via a modified face-lift incision to prevent Frey syndrome and depressed deformity. (21558897)
2011
15
Frey syndrome in neurofibromatosis 1. (22698902)
2011
16
Two rare causes of frey syndrome. (23139585)
2010
17
The buccal fat: a convenient and effective autologous option to prevent Frey syndrome and for facial contouring following parotidectomy. (20517094)
2010
18
Ethics of Frey syndrome: ensuring that consent is truly informed. (20641103)
2010
19
An unusual cause of Frey syndrome. (18804316)
2009
20
Management of Frey syndrome using botulinum neurotoxin: a case report. (19900355)
2009
21
Repeated botulinum toxin type A injections to treat patients with Frey syndrome. (19289708)
2009
22
Prevention of Frey syndrome in parotid gland surgery. (17963668)
2007
23
A review of the surgical and medical treatment of Frey syndrome. (17060744)
2006
24
Frey syndrome prevalence after partial parotidectomy. (16917561)
2006
25
Gustatory sweating: Frey syndrome. (16344505)
2005
26
Frey syndrome. A proposal for evaluating severity. (15006622)
2004
27
Sternocleidomastoid muscle flap preventing Frey syndrome following parotidectomy. (15022023)
2004
28
Use of AlloDerm implant to prevent frey syndrome after parotidectomy. (12533152)
2003
29
Botulinum toxin A in the treatment of patients with Frey syndrome. (11851676)
2002
30
Frey syndrome--delayed clinical onset: a case report. (12324790)
2002
31
Treatment of Frey syndrome with botulinum toxin type F. (11255487)
2001
32
What syndrome is this? Auriculotemporal nerve (Frey) syndrome. (11085676)
2000
33
The fallacy of preventing Frey syndrome during parotidectomy. (10772317)
2000
34
Parotid surgery and Frey syndrome. (10979140)
2000
35
Frey syndrome treatment with botulinum toxin. (10828793)
2000
36
Frey syndrome: treatment with type A botulinum toxin. (11042557)
2000
37
Auriculotemporal (Frey) syndrome in late childhood: an unusual variant presenting as gustatory flushing mimicking food allergy. (10792802)
2000
38
Frey syndrome before Frey: the correct history. (10499057)
1999
39
Recurrent gustatory sweating (Frey syndrome) after intracutaneous injection of botulinum toxin type A: incidence, management, and outcome. (10190799)
1999
40
Frey syndrome: treatment with temporoparietal fascia flap interposition. (10406323)
1999
41
An alternative treatment for Frey syndrome. (9950578)
1999
42
Prevention of Frey syndrome during parotidectomy. (10448728)
1999
43
Atypical Frey syndrome as a complication of Obwegeser osteotomy. (10029768)
1998
44
Localized facial flushing in infancy. Auriculotemporal nerve (Frey) syndrome. (9301592)
1997
45
The Frey syndrome: a simple, effective treatment. (6817270)
1982
46
The Frey syndrome: a review and double blind evaluation of the topical use of a new anticholinergic agent. (362094)
1978
47
A reevaluation of the Frey syndrome following parotid surgery. (857787)
1977
48
The intratympanic correction of Frey syndrome. (4813335)
1974
49
The auriculo-temporal or Frey syndrome and tympanic neurectomy. (4295139)
1968
50
The auriculotemporal (Frey) syndrome occurring after parotid surgery. (13778730)
1960

Genetic Variations for Frey Syndrome

About this section

Expression for genes affiliated with Frey Syndrome

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Frey Syndrome

Search GEO for disease gene expression data for Frey Syndrome.

Pathways for genes affiliated with Frey Syndrome

About this section

Compounds for genes affiliated with Frey Syndrome

About this section
Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 28IUPHAR
See all sources

Compounds related to Frey Syndrome according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1tacrolimus44 49 1111.3AKAP5, PDP1
2atp44 2810.1SRL, AKAP5, PDP1
3threonine448.5IKBKAP, ETS2, AKAP5, PDP1
4serine448.4PDP1, AKAP5, ETS2, IKBKAP

GO Terms for genes affiliated with Frey Syndrome

About this section

Products for genes affiliated with Frey Syndrome

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Frey Syndrome

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet