FTD
MCID: FRN006
MIFTS: 70

Frontotemporal Dementia (FTD) malady

Genetic diseases, Rare diseases, Neuronal diseases, Mental diseases categories

Summaries for Frontotemporal Dementia

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44NIH Rare Diseases, 45NINDS, 66Wikipedia, 48OMIM, 34MalaCards
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NIH Rare Diseases:44 Frontotemporal dementia describes a group of conditions associated with shrinking of the frontal and temporal anterior lobes of the brain. symptoms include either variable changes in behavior (e.g., impulsive, bored, listless, lack of social contact, lack of empathy, distractibility, blunted emotions, compulsive behavior, decreased energy and motivation) or problems with language (e.g., difficulty making or understanding speech). spatial skills and memory remain intact. there is a strong genetic component to the disease; it often runs in families. there is no cure for frontotemporal dementia at this time, as a result treatment remains supportive.although the name and classification of ftd has been a topic of discussion for over a century, the current classification of the syndrome groups together pick’s disease, primary progressive aphasia, and semantic dementia as ftd. some doctors propose adding corticobasal degeneration and progressive supranuclear palsy to ftd and calling the group pick complex. you can click on the links to view the gard pages on these conditions. last updated: 8/22/2011

MalaCards: Frontotemporal Dementia, also known as multiple system tauopathy with presenile dementia, is related to dementia and lateral sclerosis. An important gene associated with Frontotemporal Dementia is PSEN1 (presenilin 1), and among its related pathways are Alzheimers Disease Pathway and Fanconi anemia pathway. The compounds spec-t and thioflavin have been mentioned in the context of this disorder. Affiliated tissues include brain, temporal lobe and bone, and related mouse phenotypes are muscle and skeleton.

NINDS:45 Frontotemporal dementia (FTD) describes a clinical syndrome associated with shrinking of the frontal and temporal anterior lobes of the brain. Originally known as Pick?s disease, the name and classification of FTD has been a topic of discussion for over a century.

Wikipedia:66 Frontotemporal dementia (FTD) is a neurodegenerative disease characterized by progressive neuronal loss... more...

Description from OMIM:48 600274

Aliases & Classifications for Frontotemporal Dementia

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9Disease Ontology, 44NIH Rare Diseases, 45NINDS, 11DISEASES, 46Novoseek, 63UMLS, 10diseasecard, 23GTR, 48OMIM, 59SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases
Anatomical: Neuronal diseases, Mental diseases


Aliases & Descriptions:

frontotemporal dementia 9 44 45 11 46 63
multiple system tauopathy with presenile dementia 9 44 63
dementia, frontotemporal 10 23 48
frontotemporal lobar degeneration 9 63
pallidopontonigral degeneration 9 63
dementia, frontotemporal, with parkinsonism 44
frontotemporal dementia with parkinsonism 44
frontotemporal lobe dementia 44
wilhelmsen-lynch disease 9
mstd 44
ftd 44


External Ids:

Disease Ontology9 DOID:9255
SNOMED-CT59 42369001
OMIM48 600274

Related Diseases for Frontotemporal Dementia

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18GeneCards, 19GeneDecks
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Diseases in the Frontotemporal Dementia family:

Grn-Related Frontotemporal Dementia Tardbp-Related Frontotemporal Dementia
Chmp2b-Related Frontotemporal Dementia

Diseases related to Frontotemporal Dementia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 114)
idRelated DiseaseScoreTop Affiliating Genes
1dementia32.2PSEN1, SNCA, RPS27A, MAPT, GRN, TARDBP
2lateral sclerosis31.5SOD1, SNCA, MAPT
3alzheimer's disease31.3SOD1, VCP, PSEN1, SNCA, RPS27A, MAPT
4pick's disease31.2PSEN1, MAPT
5semantic dementia31.2GRN, RPS27A, MAPT
6primary progressive aphasia31.2RPS27A, MAPT, GRN
7aphasia31.1FUS, C9orf72, MAPT, GRN, TARDBP
8progressive supranuclear palsy31.1SNCA, RPS27A, MAPT
9motor neuron disease31.1SOD1, VCP, SNCA, RPS27A, MAPT, GRN
10amyotrophic lateral sclerosis31.0FUS, C9orf72, SOD1, VCP, CHMP2B, PSEN1
11tauopathy30.8PSEN1, SNCA, RPS27A, MAPT, GRN
12inclusion body myopathy with early-onset paget disease and frontotemporal dementia 130.8VCP
13lewy body dementia30.5SNCA, MAPT
14inclusion body myositis30.5MAPT, RPS27A
15apraxia30.5GRN, MAPT
16parkinson's disease30.5SNCA, RPS27A, MAPT
17myositis30.4PSEN1, SNCA, RPS27A, MAPT
18amyloidosis30.4MAPT, RPS27A, SNCA, PSEN1
19frontotemporal lobar degeneration with ubiquitin-positive inclusions30.4GRN
20rem sleep behavior disorder30.3SNCA
21huntington's disease30.3SOD1, PSEN1, SNCA, RPS27A, MAPT
22prion disease30.2MAPT, PSEN1
23memory impairment30.1PSEN1, SNCA, MAPT, GRN
24vascular dementia30.1PSEN1, SNCA, RPS27A, MAPT
25neuronitis10.9
26myopathy10.8
27inclusion body myopathy with early-onset paget disease and frontotemporal dementia10.8
28grn-related frontotemporal dementia10.8
29corticobasal degeneration10.7
30amyotrophic lateral sclerosis with frontotemporal dementia10.7
31frontotemporal dementia with parkinsonism-1710.6
32schizophrenia10.6
33chmp2b-related frontotemporal dementia10.6
34cerebritis10.6
35frontotemporal dementia, chromosome 3-linked10.5
36inclusion body myopathy with paget disease of bone and/or frontotemporal dementia10.5
37frontotemporal lobar degeneration, tardbp-related10.4
38intracranial hypotension10.4
39frontotemporal dementia, ubiquitin-positive10.4
40amyotrophic lateral sclerosis 14, with or without frontotemporal dementia10.4
41paget's disease of bone10.4
42pathological gambling10.4
43bipolar disorder10.4
44tardbp-related frontotemporal dementia10.4
45inclusion body myopathy wtih early-onset paget disease without frontotemporal dementia 310.4
46prosopagnosia10.3
47adult polyglucosan body disease10.3
48spasticity10.3
49vitamin b12 deficiency10.3
50progressive non-fluent aphasia10.3

Graphical network of the top 20 diseases related to Frontotemporal Dementia:



Diseases related to frontotemporal dementia

Symptoms for Frontotemporal Dementia

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48OMIM
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Symptoms by clinical synopsis from OMIM:

600274

Clinical features from OMIM:

600274

Drugs & Therapeutics for Frontotemporal Dementia

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Frontotemporal Dementia

Drug clinical trials:

Search ClinicalTrials for Frontotemporal Dementia

Search NIH Clinical Center for Frontotemporal Dementia

Search CenterWatch for Frontotemporal Dementia

Genetic Tests for Frontotemporal Dementia

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23GTR
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Genetic tests related to Frontotemporal Dementia:

id Genetic test Affiliating Genes
1 Frontotemporal Dementia23

Anatomical Context for Frontotemporal Dementia

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34MalaCards
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MalaCards organs/tissues related to Frontotemporal Dementia:

34
Brain, Temporal lobe, Bone, Cortex, Testes, Eye, Prefrontal cortex, Monocytes, Hypothalamus

Animal Models for Frontotemporal Dementia or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Frontotemporal Dementia:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.5SOD1, VCP, PSEN1, MAPT, TARDBP
2MP:00053908.4TARDBP, SNCA, PSEN1, VCP, SOD1
3MP:00030128.3FUS, C9orf72, SNCA, MAPT, GRN, TARDBP
4MP:00053978.1FUS, SOD1, VCP, PSEN1, MAPT, GRN
5MP:00053867.6TARDBP, FUS, SOD1, VCP, PSEN1, SNCA
6MP:00053877.6FUS, SOD1, VCP, PSEN1, SNCA, MAPT
7MP:00053847.6FUS, SOD1, VCP, PSEN1, SNCA, MAPT
8MP:00036317.5FUS, SOD1, VCP, PSEN1, SNCA, MAPT
9MP:00107687.3FUS, SOD1, VCP, PSEN1, SNCA, MAPT

Publications for Frontotemporal Dementia

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53PubMed
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Articles related to Frontotemporal Dementia:

(show top 50)    (show all 800)
idTitleAuthorsYear
1
Sleep in frontotemporal dementia is equally or possibly more disrupted, and at an earlier stage, when compared to sleep in Alzheimer's disease. (24077430)
2014
2
Unravelling the mysteries of frontotemporal dementia. (24279193)
2013
3
Psychosis and hallucinations in frontotemporal dementia with the C9ORF72 mutation: a detailed clinical cohort. (24077574)
2013
4
Neural correlates of activities of daily living in frontotemporal dementia. (23427102)
2013
5
Plasma phosphorylated TDP-43 levels are elevated in patients with frontotemporal dementia carrying a C9orf72 repeat expansion or a GRN mutation. (24309270)
2013
6
Episodic memory impairment in frontotemporal dementia; a a8^a8^mTc- HMPAO SPECT study. (23016870)
2013
7
Observation of Social Behavior in Frontotemporal Dementia. (24370617)
2013
8
Homozygosity for the C9orf72 GGGGCC repeat expansion in frontotemporal dementia. (23818065)
2013
9
A novel compound heterozygous mutation in TREM2 found in a Turkish frontotemporal dementia-like family. (23870839)
2013
10
Hope abandoned: memantine therapy in frontotemporal dementia. (23305744)
2013
11
Frequency of the C9orf72 hexanucleotide repeat expansion in patients with amyotrophic lateral sclerosis and frontotemporal dementia: a cross-sectional study. (22406228)
2012
12
Distinct clinical and pathological characteristics of frontotemporal dementia associated with C9ORF72 mutations. (22300873)
2012
13
Autopsy-proven progressive supranuclear palsy presenting as behavioral variant frontotemporal dementia. (22181323)
2012
14
The frontal-anatomic specificity of design fluency repetitions and their diagnostic relevance for behavioral variant frontotemporal dementia. (22835330)
2012
15
UBQLN2/P62 cellular recycling pathways in amyotrophic lateral sclerosis and frontotemporal dementia. (22246868)
2012
16
Diagnosis and management of behavioral issues in frontotemporal dementia. (22847063)
2012
17
A frontotemporal dementia-like syndrome mimicking postpartum depression detected by 18F fluorodeoxyglucose positron emission tomography. (22889797)
2012
18
Phenotypic signatures of genetic frontotemporal dementia. (21986680)
2011
19
The birth and early evolution of the frontotemporal dementia (FTD) concept. (21647707)
2011
20
Postural instability, frontotemporal dementia, and ophthalmoplegia: clinicopathological case. (21755535)
2011
21
Magnetoencephalography of frontotemporal dementia: spatiotemporally localized changes during semantic decisions. (21840892)
2011
22
Clinical staging and disease progression in frontotemporal dementia. (20479357)
2010
23
Frontotemporal dementia phenotype associated with MAPT gene duplication. (20634582)
2010
24
The plight of caring for young patients with frontotemporal dementia. (20107238)
2010
25
Two Australian families with inclusion-body myopathy, Paget's disease of bone and frontotemporal dementia: novel clinical and genetic findings. (20335036)
2010
26
Acquired savant syndrome in frontotemporal dementia. (21921550)
2010
27
Inclusion body myopathy and frontotemporal dementia caused by a novel VCP mutation. (17889967)
2009
28
No association of common VCP variants with sporadic frontotemporal dementia. (17618707)
2009
29
Intracranial hypotension causing reversible frontotemporal dementia and coma. (19378725)
2009
30
Survival profiles of patients with frontotemporal dementia and motor neuron disease. (19901167)
2009
31
Defining "prodromal" Alzheimer's disease, frontotemporal dementia, and Lewy body dementia: are we there yet? (18327642)
2008
32
The tau S305S mutation causes frontotemporal dementia with parkinsonism. (18093153)
2008
33
Re: Brain SPECT perfusion of frontotemporal dementia associated with motor neuron disease. (18427076)
2008
34
Distinctions between the dementia in amyotrophic lateral sclerosis with frontotemporal dementia and the dementia of Alzheimer's disease. (17917849)
2007
35
Tau isoform expression in frontotemporal dementia without tau deposition. (17976991)
2007
36
Frontotemporal dementia and Parkinsonism linked to chromosome 17 with the N279K tau mutation. (17319286)
2007
37
Brain spect perfusion of frontotemporal dementia associated with motor neuron disease. (17664410)
2007
38
SR protein 9G8 modulates splicing of tau exon 10 via its proximal downstream intron, a clustering region for frontotemporal dementia mutations. (17137791)
2007
39
Clinical and genetic features of families with frontotemporal dementia and parkinsonism linked to chromosome 17 with a P301S tau mutation. (17318302)
2007
40
The mini-mental state examination in behavioral variant frontotemporal dementia and primary progressive aphasia. (18166606)
2007
41
Neurocognitive differential diagnosis of dementing diseases: Alzheimer's Dementia, Vascular Dementia, Frontotemporal Dementia, and Major Depressive Disorder. (17000529)
2006
42
Frontotemporal dementia, semantic dementia, and Alzheimer's disease: the contribution of standard neuropsychological tests to differential diagnosis. (15681627)
2005
43
17q-linked frontotemporal dementia-amyotrophic lateral sclerosis without tau mutations with tau and alpha-synuclein inclusions. (15023818)
2004
44
Familial frontotemporal dementia associated with a novel presenilin-1 mutation. (12053127)
2002
45
Memory consolidation and the hippocampus: further evidence from studies of autobiographical memory in semantic dementia and frontal variant frontotemporal dementia. (11792404)
2002
46
Frontotemporal dementia with ubiquitinated cytoplasmic and intranuclear inclusions. (11547957)
2001
47
Search for a mutation in the tau gene in a Swiss family with frontotemporal dementia. (10683298)
2000
48
Neuropathological discrepancy between Japanese Pick's disease without Pick bodies and frontal lobe degeneration type of frontotemporal dementia proposed by Lund and Manchester Group. (10935442)
2000
49
Tau mutations in frontotemporal dementia FTDP-17 and their relevance for Alzheimer's disease. (10899436)
2000
50
High prevalence of mutations in the microtubule-associated protein tau in a population study of frontotemporal dementia in the Netherlands. (9973279)
1999

Variations for Frontotemporal Dementia

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Sources:
65UniProtKB/Swiss-Prot, 1 National Center for Biotechnology Information (Clinvar), 8dbSNP
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UniProtKB/Swiss-Prot genetic disease variations for Frontotemporal Dementia:

65 (show all 12)
id Symbol AA change Variation ID SNP ID
1MAPTp.Gly589ValVAR_010345
2MAPTp.Asn596LysVAR_010346
3MAPTp.Pro618LeuVAR_010348
4MAPTp.Pro618SerVAR_010349
5MAPTp.Ser622AsnVAR_010350
6MAPTp.Val654MetVAR_010351
7MAPTp.Arg5HisVAR_019660rs63750959
8MAPTp.Leu583ValVAR_019662
9MAPTp.Asn613HisVAR_019663
10MAPTp.Glu659ValVAR_019666
11MAPTp.Lys634MetVAR_037440
12PSEN1p.Leu113ProVAR_016215

Clinvar genetic disease variations for Frontotemporal Dementia:

1 (show all 18)
id Gene Name Type Significance SNP ID Assembly Location
1MAPTNM_016835.4(MAPT): c.1853C> T (p.Pro618Leu)single nucleotide variantPathogenicrs63751273GRCh37Chr 17, 44087755: 44087755
2MAPTNM_016835.4(MAPT): c.1766G> T (p.Gly589Val)single nucleotide variantPathogenicrs63750376GRCh37Chr 17, 44074023: 44074023
3MAPTNM_016835.4(MAPT): c.2167C> T (p.Arg723Trp)single nucleotide variantPathogenicrs63750424GRCh37Chr 17, 44101427: 44101427
4MAPTNM_016835.4(MAPT): c.1866+14C> Tsingle nucleotide variantPathogenicrs63750972GRCh37Chr 17, 44087782: 44087782
5MAPTMAPT, IVS10, A-G, +13single nucleotide variantPathogenic
6MAPTMAPT, IVS10, C-T, +16single nucleotide variantPathogenic
7MAPTMAPT, IVS10, G-A, +1single nucleotide variantPathogenic
8MAPTNM_016835.4(MAPT): c.1960G> A (p.Val654Met)single nucleotide variantPathogenicrs63750570GRCh37Chr 17, 44095995: 44095995
9MAPTNM_016835.4(MAPT): c.1788T> G (p.Asn596Lys)single nucleotide variantPathogenicrs63750756GRCh37Chr 17, 44087690: 44087690
10MAPTNM_016835.4(MAPT): c.1865G> A (p.Ser622Asn)single nucleotide variantPathogenicrs63751165GRCh37Chr 17, 44087767: 44087767
11MAPTNM_016835.4(MAPT): c.1852C> T (p.Pro618Ser)single nucleotide variantPathogenicrs63751438GRCh37Chr 17, 44087754: 44087754
12MAPTNM_016835.4(MAPT): c.1839T> C (p.Asn613=)single nucleotide variantPathogenicrs63750912GRCh37Chr 17, 44087741: 44087741
13MAPTNM_016835.4(MAPT): c.1976A> T (p.Glu659Val)single nucleotide variantPathogenicrs63750711GRCh37Chr 17, 44096011: 44096011
14MAPTNM_016835.4(MAPT): c.14G> A (p.Arg5His)single nucleotide variantPathogenicrs63750959GRCh37Chr 17, 44039717: 44039717
15MAPTMAPT, IVS10, T-C, +11single nucleotide variantPathogenic
16MAPTNM_016835.4(MAPT): c.1747C> G (p.Leu583Val)single nucleotide variantPathogenicrs63750349GRCh37Chr 17, 44074004: 44074004
17MAPTNM_016835.4(MAPT): c.1901A> T (p.Lys634Met)single nucleotide variantPathogenicrs63750092GRCh37Chr 17, 44091643: 44091643
18PSEN1NM_000021.3(PSEN1): c.338T> C (p.Leu113Pro)single nucleotide variantPathogenicrs63751399GRCh37Chr 14, 73637755: 73637755

Expression for genes affiliated with Frontotemporal Dementia

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Frontotemporal Dementia

Search GEO for disease gene expression data for Frontotemporal Dementia.

Pathways for genes affiliated with Frontotemporal Dementia

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Sources:
51PathCards, 54QIAGEN, 31KEGG, 56Reactome, 39NCBI BioSystems Database, 5Cell Signaling Technology
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Pathways related to Frontotemporal Dementia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0MAPT, PSEN1
2
Show member pathways
9.7VCP, RPS27A
3
Show member pathways
9.6RPS27A, CHMP2B
4
Show member pathways
Alzheimers Disease39
9.4MAPT, SNCA, PSEN1
5
Show member pathways
8.8HNRNPA2B1, HNRNPA1, FUS
68.5TARDBP, MAPT, SNCA, PSEN1, SOD1

Compounds for genes affiliated with Frontotemporal Dementia

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Sources:
46Novoseek, 25HMDB, 12DrugBank, 30IUPHAR, 62Tocris Bioscience
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Compounds related to Frontotemporal Dementia according to GeneCards/GeneDecks:

(show all 39)
idCompoundScoreTop Affiliating Genes
1spec-t4610.1MAPT, PSEN1
2thioflavin4610.0MAPT, SNCA
3tmao4610.0MAPT, SNCA
4fluorochrome469.9RPS27A, MAPT
5dicoumarol469.7RPS27A, SOD1
6glycerol46 25 1211.7MAPT, RPS27A, PSEN1
73-nitrotyrosine469.7SNCA, SOD1
8carbachol46 30 1211.7MAPT, SNCA, PSEN1
9carnosine46 2510.6SOD1, SNCA
10choline46 25 1211.6MAPT, SNCA, PSEN1
118-oxo-dg469.6SNCA, SOD1
12selegiline46 1210.5SOD1, SNCA
13thioflavine s469.5SNCA, RPS27A, MAPT
14peroxynitrite469.5SOD1, PSEN1, SNCA
15silver469.4MAPT, RPS27A, SNCA
16methionine469.4PSEN1, SNCA, MAPT
17sodium dodecylsulfate469.4MAPT, RPS27A, SNCA
18mg 13246 6210.4SNCA, RPS27A, MAPT
19superoxide46 2510.4TARDBP, PSEN1, VCP, SOD1
20lactacystin469.3MAPT, RPS27A, SNCA, PSEN1
21valine469.2MAPT, RPS27A, SNCA, PSEN1
22rotenone469.2SOD1, SNCA, RPS27A
236-hydroxydopamine469.2RPS27A, SNCA, SOD1
24glycogen46 2510.2MAPT, RPS27A, SNCA, PSEN1
25nmda46 3010.2PSEN1, RPS27A, MAPT
26levodopa46 1210.2SOD1, SNCA, RPS27A
27threonine469.1MAPT, RPS27A, PSEN1, VCP
28polysaccharide469.1RPS27A, SNCA, VCP
29formate469.0SOD1, SNCA, RPS27A, MAPT
30glutamine469.0VCP, PSEN1, SNCA, RPS27A, MAPT
31n acetylcysteine468.9MAPT, RPS27A, SNCA, SOD1
32zinc46 259.9MAPT, RPS27A, SOD1, FUS
334-hydroxynonenal46 259.7MAPT, RPS27A, SNCA, PSEN1, SOD1
34h2o2468.7SOD1, PSEN1, SNCA, RPS27A, MAPT
35arginine468.7SOD1, PSEN1, SNCA, RPS27A, MAPT
36glutamate468.7MAPT, RPS27A, SNCA, PSEN1, SOD1
37alanine468.7SOD1, PSEN1, SNCA, RPS27A, MAPT
38serine468.6MAPT, RPS27A, SNCA, PSEN1, VCP
39cysteine468.4SOD1, PSEN1, SNCA, RPS27A, MAPT, GRN

GO Terms for genes affiliated with Frontotemporal Dementia

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17Gene Ontology
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Cellular components related to Frontotemporal Dementia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nuclear outer membraneGO:0056409.6PSEN1, SNCA
2growth coneGO:0304269.6PSEN1, MAPT, SNCA
3rough endoplasmic reticulumGO:0057919.5SNCA, PSEN1
4axonGO:0304249.5PSEN1, SNCA, MAPT
5mitochondrionGO:0057398.5PSEN1, GRN, SNCA, CHMP2B, SOD1
6extracellular vesicular exosomeGO:0700628.3VCP, CHMP2B, RPS27A, HNRNPA1, SOD1
7cytosolGO:0058297.6RPS27A, MAPT, SOD1, VCP, CHMP2B, SNCA
8nucleusGO:0056347.1TARDBP, FUS, C9orf72, SOD1, VCP, CHMP2B
9cytoplasmGO:0057376.9FUS, SOD1, VCP, CHMP2B, SNCA, HNRNPA1

Biological processes related to Frontotemporal Dementia according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1Notch receptor processingGO:0072209.9RPS27A, PSEN1
2positive regulation of proteasomal ubiquitin-dependent protein catabolic processGO:0324369.9VCP, PSEN1
3positive regulation of receptor recyclingGO:0019219.8SNCA, PSEN1
4embryo implantationGO:0075669.6GRN, SOD1
5thymus developmentGO:0485389.4PSEN1, SOD1
6negative regulation of neuron apoptotic processGO:0435249.3SNCA, PSEN1, SOD1
7positive regulation of apoptotic processGO:0430659.2RPS27A, PSEN1, SOD1
8mRNA splicing, via spliceosomeGO:0003989.0FUS, HNRNPA1, HNRNPA2B1
9mRNA processingGO:0063978.9TARDBP, HNRNPA2B1, HNRNPA1
10RNA splicingGO:0083808.7FUS, HNRNPA1, HNRNPA2B1, TARDBP
11gene expressionGO:0104678.3FUS, RPS27A, HNRNPA1, HNRNPA2B1
12cell deathGO:0082198.3TARDBP, UBQLN2, GRN, HNRNPA1, CHMP2B, C9orf72

Molecular functions related to Frontotemporal Dementia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein domain specific bindingGO:0199049.2SNCA, CHMP2B, VCP
2nucleotide bindingGO:0001668.3FUS, HNRNPA1, HNRNPA2B1, TARDBP
3identical protein bindingGO:0428028.3FUS, SOD1, VCP, SNCA, TARDBP
4RNA bindingGO:0037238.1TARDBP, HNRNPA2B1, HNRNPA1, FUS
5poly(A) RNA bindingGO:0448227.4FUS, VCP, RPS27A, HNRNPA1, HNRNPA2B1, GRN
6protein bindingGO:0055155.7TARDBP, FUS, C9orf72, SOD1, VCP, PSEN1

Products for genes affiliated with Frontotemporal Dementia

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Sources for Frontotemporal Dementia

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet