FTD
MCID: FRN006
MIFTS: 70

Frontotemporal Dementia (FTD) malady

Genetic diseases, Rare diseases, Neuronal diseases, Mental diseases categories
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Summaries for Frontotemporal Dementia

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NIH Rare Diseases:42 Frontotemporal dementia describes a group of conditions associated with shrinking of the frontal and temporal anterior lobes of the brain. symptoms include either variable changes in behavior (e.g., impulsive, bored, listless, lack of social contact, lack of empathy, distractibility, blunted emotions, compulsive behavior, decreased energy and motivation) or problems with language (e.g., difficulty making or understanding speech). spatial skills and memory remain intact. there is a strong genetic component to the disease; it often runs in families. there is no cure for frontotemporal dementia at this time, as a result treatment remains supportive.although the name and classification of ftd has been a topic of discussion for over a century, the current classification of the syndrome groups together pick’s disease, primary progressive aphasia, and semantic dementia as ftd. some doctors propose adding corticobasal degeneration and progressive supranuclear palsy to ftd and calling the group pick complex. you can click on the links to view the gard pages on these conditions. last updated: 8/22/2011

MalaCards based summary: Frontotemporal Dementia, also known as multiple system tauopathy with presenile dementia, is related to dementia and pick's disease, and has symptoms including An important gene associated with Frontotemporal Dementia is PSEN1 (presenilin 1), and among its related pathways are Alzheimers Disease Pathway and Fanconi anemia pathway. The compounds spec-t and thioflavin have been mentioned in the context of this disorder. Affiliated tissues include brain, bone and temporal lobe, and related mouse phenotypes are muscle and skeleton.

NINDS:43 Frontotemporal dementia (FTD) describes a clinical syndrome associated with shrinking of the frontal and temporal anterior lobes of the brain. Originally known as Pick?s disease, the name and classification of FTD has been a topic of discussion for over a century.

Wikipedia:65 Frontotemporal dementia (FTD) is the clinical presentation of frontotemporal lobar degeneration, which... more...

Description from OMIM:46 600274

Aliases & Classifications for Frontotemporal Dementia

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Frontotemporal Dementia, Aliases & Descriptions:

Name: Frontotemporal Dementia 8 42 43 10 44 62
Multiple System Tauopathy with Presenile Dementia 8 42 62
Dementia, Frontotemporal 9 22 46
Frontotemporal Dementia with Parkinsonism 42 62
Frontotemporal Lobar Degeneration 8 62
Pallidopontonigral Degeneration 8 62
 
Frontotemporal Lobe Dementia 42 62
Wilhelmsen-Lynch Disease 8 62
Dementia, Frontotemporal, with Parkinsonism 42
Mstd 42
Ftd 42


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases
Anatomical: Neuronal diseases, Mental diseases


External Ids:

Disease Ontology8 DOID:9255
SNOMED-CT57 42369001
OMIM46 600274

Related Diseases for Frontotemporal Dementia

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Diseases in the Frontotemporal Dementia family:

Grn-Related Frontotemporal Dementia Tardbp-Related Frontotemporal Dementia
Chmp2b-Related Frontotemporal Dementia

Diseases related to Frontotemporal Dementia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 122)
idRelated DiseaseScoreTop Affiliating Genes
1dementia31.6TARDBP, VCP, MAPT, RPS27A, SNCA, PSEN1
2pick's disease31.6PSEN1, MAPT
3lateral sclerosis31.5SNCA, MAPT, SOD1
4semantic dementia31.5MAPT, GRN, RPS27A
5primary progressive aphasia31.5MAPT, RPS27A, GRN
6inclusion body myopathy with early-onset paget disease and frontotemporal dementia 131.4VCP
7aphasia31.2FUS, TARDBP, GRN, MAPT, C9orf72
8progressive supranuclear palsy31.2SNCA, RPS27A, MAPT
9frontotemporal lobar degeneration with ubiquitin-positive inclusions31.0GRN
10inclusion body myositis30.9RPS27A, MAPT
11rem sleep behavior disorder30.7SNCA
12lewy body dementia30.6SNCA, MAPT
13apraxia30.6GRN, MAPT
14parkinson's disease30.5MAPT, SNCA, RPS27A
15tauopathy30.5MAPT, GRN, RPS27A, SNCA, PSEN1
16prion disease30.5PSEN1, MAPT
17motor neuron disease30.5TARDBP, GRN, MAPT, RPS27A, SNCA, VCP
18alzheimer's disease30.4PSEN1, TARDBP, MAPT, RPS27A, SOD1, SNCA
19myositis30.2SNCA, MAPT, RPS27A, PSEN1
20amyloidosis30.2MAPT, PSEN1, SNCA, RPS27A
21memory impairment30.1MAPT, GRN, PSEN1, SNCA
22vascular dementia30.0SNCA, MAPT, PSEN1, RPS27A
23huntington's disease29.8MAPT, SOD1, SNCA, RPS27A, PSEN1
24amyotrophic lateral sclerosis type 1428.5FUS, C9orf72, SOD1, VCP, CHMP2B, PSEN1
25amyotrophic lateral sclerosis11.0
26neuronitis10.9
27myopathy10.8
28inclusion body myopathy with early-onset paget disease and frontotemporal dementia10.8
29grn-related frontotemporal dementia10.8
30corticobasal degeneration10.7
31chmp2b-related frontotemporal dementia10.7
32ftdals110.7
33frontotemporal dementia with parkinsonism-1710.7
34inclusion body myopathy with paget disease of bone and frontotemporal dementia10.6
35schizophrenia10.6
36amyotrophic lateral sclerosis 14, with or without frontotemporal dementia10.6
37cerebritis10.6
38frontotemporal dementia, chromosome 3-linked10.5
39adult polyglucosan body disease10.5
40frontotemporal lobar degeneration, tardbp-related10.5
41neuronal intranuclear inclusion disease10.4RPS27A
42intracranial hypotension10.4
43frontotemporal dementia, ubiquitin-positive10.4
44bipolar disorder10.4
45paget's disease of bone10.4
46pathological gambling10.4
47ftdals210.4
48tardbp-related frontotemporal dementia10.4
49prosopagnosia10.3
50spasticity10.3

Graphical network of the top 20 diseases related to Frontotemporal Dementia:



Diseases related to frontotemporal dementia

Symptoms for Frontotemporal Dementia

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Symptoms by clinical synopsis from OMIM:

600274

Clinical features from OMIM:

600274

HPO human phenotypes related to Frontotemporal Dementia:

(show all 16)
id Description Frequency HPO Source Accession
1 autosomal dominant inheritance HP:0000006
2 hyperorality HP:0000710
3 frontal lobe dementia HP:0000727
4 disinhibition HP:0000734
5 irritability HP:0000737
6 apathy HP:0000741
7 inappropriate laughter HP:0000748
8 personality changes HP:0000751
9 parkinsonism HP:0001300
10 frontotemporal dementia HP:0002145
11 language impairment HP:0002463
12 primitive reflexes (palmomental, snout, glabellar) HP:0002476
13 neuronal loss in central nervous system HP:0002529
14 polyphagia HP:0002591
15 amyotrophic lateral sclerosis HP:0007354
16 inappropriate sexual behavior HP:0008768

Drugs & Therapeutics for Frontotemporal Dementia

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Drug clinical trials:

Search ClinicalTrials for Frontotemporal Dementia

Search NIH Clinical Center for Frontotemporal Dementia

Genetic Tests for Frontotemporal Dementia

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Genetic tests related to Frontotemporal Dementia:

id Genetic test Affiliating Genes
1 Frontotemporal Dementia22

Anatomical Context for Frontotemporal Dementia

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MalaCards organs/tissues related to Frontotemporal Dementia:

32
Brain, Bone, Temporal lobe, Cortex, Testes, Eye, Prefrontal cortex, Monocytes, Hypothalamus

Animal Models for Frontotemporal Dementia or affiliated genes

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MGI Mouse Phenotypes related to Frontotemporal Dementia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.5MAPT, PSEN1, SOD1, TARDBP, VCP
2MP:00053908.4TARDBP, SOD1, VCP, PSEN1, SNCA
3MP:00030128.3FUS, C9orf72, SNCA, MAPT, GRN, TARDBP
4MP:00053978.1FUS, SOD1, VCP, PSEN1, MAPT, GRN
5MP:00053867.6MAPT, TARDBP, SNCA, PSEN1, VCP, SOD1
6MP:00053877.6VCP, SOD1, FUS, MAPT, PSEN1, SNCA
7MP:00053847.6FUS, SOD1, VCP, PSEN1, GRN, TARDBP
8MP:00036317.5TARDBP, FUS, VCP, SNCA, MAPT, GRN
9MP:00107687.3TARDBP, GRN, MAPT, SNCA, PSEN1, VCP

Publications for Frontotemporal Dementia

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Articles related to Frontotemporal Dementia:

(show top 50)    (show all 827)
idTitleAuthorsYear
1
Frontotemporal dementia and primary progressive aphasia, a review. (24966676)
2014
2
Longitudinal diffusion tensor imaging in frontotemporal dementia. (25363208)
2014
3
Sleep in frontotemporal dementia is equally or possibly more disrupted, and at an earlier stage, when compared to sleep in Alzheimer's disease. (24077430)
2014
4
Unravelling the mysteries of frontotemporal dementia. (24279193)
2013
5
Psychosis and hallucinations in frontotemporal dementia with the C9ORF72 mutation: a detailed clinical cohort. (24077574)
2013
6
Neural correlates of activities of daily living in frontotemporal dementia. (23427102)
2013
7
Plasma phosphorylated TDP-43 levels are elevated in patients with frontotemporal dementia carrying a C9orf72 repeat expansion or a GRN mutation. (24309270)
2013
8
Episodic memory impairment in frontotemporal dementia; a a8^a8^mTc- HMPAO SPECT study. (23016870)
2013
9
Observation of Social Behavior in Frontotemporal Dementia. (24370617)
2013
10
Homozygosity for the C9orf72 GGGGCC repeat expansion in frontotemporal dementia. (23818065)
2013
11
A novel compound heterozygous mutation in TREM2 found in a Turkish frontotemporal dementia-like family. (23870839)
2013
12
Hope abandoned: memantine therapy in frontotemporal dementia. (23305744)
2013
13
Frequency of the C9orf72 hexanucleotide repeat expansion in patients with amyotrophic lateral sclerosis and frontotemporal dementia: a cross-sectional study. (22406228)
2012
14
Distinct clinical and pathological characteristics of frontotemporal dementia associated with C9ORF72 mutations. (22300873)
2012
15
Autopsy-proven progressive supranuclear palsy presenting as behavioral variant frontotemporal dementia. (22181323)
2012
16
The frontal-anatomic specificity of design fluency repetitions and their diagnostic relevance for behavioral variant frontotemporal dementia. (22835330)
2012
17
UBQLN2/P62 cellular recycling pathways in amyotrophic lateral sclerosis and frontotemporal dementia. (22246868)
2012
18
Diagnosis and management of behavioral issues in frontotemporal dementia. (22847063)
2012
19
Phenotypic signatures of genetic frontotemporal dementia. (21986680)
2011
20
The birth and early evolution of the frontotemporal dementia (FTD) concept. (21647707)
2011
21
Postural instability, frontotemporal dementia, and ophthalmoplegia: clinicopathological case. (21755535)
2011
22
Clinical staging and disease progression in frontotemporal dementia. (20479357)
2010
23
Frontotemporal dementia phenotype associated with MAPT gene duplication. (20634582)
2010
24
The plight of caring for young patients with frontotemporal dementia. (20107238)
2010
25
Two Australian families with inclusion-body myopathy, Paget's disease of bone and frontotemporal dementia: novel clinical and genetic findings. (20335036)
2010
26
Acquired savant syndrome in frontotemporal dementia. (21921550)
2010
27
Inclusion body myopathy and frontotemporal dementia caused by a novel VCP mutation. (17889967)
2009
28
No association of common VCP variants with sporadic frontotemporal dementia. (17618707)
2009
29
Intracranial hypotension causing reversible frontotemporal dementia and coma. (19378725)
2009
30
Survival profiles of patients with frontotemporal dementia and motor neuron disease. (19901167)
2009
31
Defining "prodromal" Alzheimer's disease, frontotemporal dementia, and Lewy body dementia: are we there yet? (18327642)
2008
32
The tau S305S mutation causes frontotemporal dementia with parkinsonism. (18093153)
2008
33
Re: Brain SPECT perfusion of frontotemporal dementia associated with motor neuron disease. (18427076)
2008
34
Distinctions between the dementia in amyotrophic lateral sclerosis with frontotemporal dementia and the dementia of Alzheimer's disease. (17917849)
2007
35
Tau isoform expression in frontotemporal dementia without tau deposition. (17976991)
2007
36
Frontotemporal dementia and Parkinsonism linked to chromosome 17 with the N279K tau mutation. (17319286)
2007
37
Brain spect perfusion of frontotemporal dementia associated with motor neuron disease. (17664410)
2007
38
SR protein 9G8 modulates splicing of tau exon 10 via its proximal downstream intron, a clustering region for frontotemporal dementia mutations. (17137791)
2007
39
Clinical and genetic features of families with frontotemporal dementia and parkinsonism linked to chromosome 17 with a P301S tau mutation. (17318302)
2007
40
Neurocognitive differential diagnosis of dementing diseases: Alzheimer's Dementia, Vascular Dementia, Frontotemporal Dementia, and Major Depressive Disorder. (17000529)
2006
41
Progranulin mutations in ubiquitin-positive frontotemporal dementia linked to chromosome 17q21. (17168647)
2006
42
Frontotemporal dementia, semantic dementia, and Alzheimer's disease: the contribution of standard neuropsychological tests to differential diagnosis. (15681627)
2005
43
17q-linked frontotemporal dementia-amyotrophic lateral sclerosis without tau mutations with tau and alpha-synuclein inclusions. (15023818)
2004
44
Familial frontotemporal dementia associated with a novel presenilin-1 mutation. (12053127)
2002
45
Memory consolidation and the hippocampus: further evidence from studies of autobiographical memory in semantic dementia and frontal variant frontotemporal dementia. (11792404)
2002
46
Frontotemporal dementia with ubiquitinated cytoplasmic and intranuclear inclusions. (11547957)
2001
47
Search for a mutation in the tau gene in a Swiss family with frontotemporal dementia. (10683298)
2000
48
Neuropathological discrepancy between Japanese Pick's disease without Pick bodies and frontal lobe degeneration type of frontotemporal dementia proposed by Lund and Manchester Group. (10935442)
2000
49
Tau mutations in frontotemporal dementia FTDP-17 and their relevance for Alzheimer's disease. (10899436)
2000
50
High prevalence of mutations in the microtubule-associated protein tau in a population study of frontotemporal dementia in the Netherlands. (9973279)
1999

Variations for Frontotemporal Dementia

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UniProtKB/Swiss-Prot genetic disease variations for Frontotemporal Dementia:

64 (show all 12)
id Symbol AA change Variation ID SNP ID
1MAPTp.Gly589ValVAR_010345
2MAPTp.Asn596LysVAR_010346
3MAPTp.Pro618LeuVAR_010348
4MAPTp.Pro618SerVAR_010349
5MAPTp.Ser622AsnVAR_010350
6MAPTp.Val654MetVAR_010351
7MAPTp.Arg5HisVAR_019660rs63750959
8MAPTp.Leu583ValVAR_019662
9MAPTp.Asn613HisVAR_019663
10MAPTp.Glu659ValVAR_019666
11MAPTp.Lys634MetVAR_037440
12PSEN1p.Leu113ProVAR_016215

Clinvar genetic disease variations for Frontotemporal Dementia:

6 (show all 18)
id Gene Name Type Significance SNP ID Assembly Location
1MAPTNM_016835.4(MAPT): c.1853C> T (p.Pro618Leu)single nucleotide variantPathogenicrs63751273GRCh37Chr 17, 44087755: 44087755
2MAPTNM_016835.4(MAPT): c.1766G> T (p.Gly589Val)single nucleotide variantPathogenicrs63750376GRCh37Chr 17, 44074023: 44074023
3MAPTNM_016835.4(MAPT): c.2167C> T (p.Arg723Trp)single nucleotide variantPathogenicrs63750424GRCh37Chr 17, 44101427: 44101427
4MAPTNM_016835.4(MAPT): c.1866+14C> Tsingle nucleotide variantPathogenicrs63750972GRCh37Chr 17, 44087782: 44087782
5MAPTMAPT, IVS10, A-G, +13single nucleotide variantPathogenic
6MAPTMAPT, IVS10, C-T, +16single nucleotide variantPathogenic
7MAPTMAPT, IVS10, G-A, +1single nucleotide variantPathogenic
8MAPTNM_016835.4(MAPT): c.1960G> A (p.Val654Met)single nucleotide variantPathogenicrs63750570GRCh37Chr 17, 44095995: 44095995
9MAPTNM_016835.4(MAPT): c.1788T> G (p.Asn596Lys)single nucleotide variantPathogenicrs63750756GRCh37Chr 17, 44087690: 44087690
10MAPTNM_016835.4(MAPT): c.1865G> A (p.Ser622Asn)single nucleotide variantPathogenicrs63751165GRCh37Chr 17, 44087767: 44087767
11MAPTNM_016835.4(MAPT): c.1852C> T (p.Pro618Ser)single nucleotide variantPathogenicrs63751438GRCh37Chr 17, 44087754: 44087754
12MAPTNM_016835.4(MAPT): c.1839T> C (p.Asn613=)single nucleotide variantPathogenicrs63750912GRCh37Chr 17, 44087741: 44087741
13MAPTNM_016835.4(MAPT): c.1976A> T (p.Glu659Val)single nucleotide variantPathogenicrs63750711GRCh37Chr 17, 44096011: 44096011
14MAPTNM_016835.4(MAPT): c.14G> A (p.Arg5His)single nucleotide variantPathogenicrs63750959GRCh37Chr 17, 44039717: 44039717
15MAPTMAPT, IVS10, T-C, +11single nucleotide variantPathogenic
16MAPTNM_016835.4(MAPT): c.1747C> G (p.Leu583Val)single nucleotide variantPathogenicrs63750349GRCh37Chr 17, 44074004: 44074004
17MAPTNM_016835.4(MAPT): c.1901A> T (p.Lys634Met)single nucleotide variantPathogenicrs63750092GRCh37Chr 17, 44091643: 44091643
18PSEN1NM_000021.3(PSEN1): c.338T> C (p.Leu113Pro)single nucleotide variantPathogenicrs63751399GRCh37Chr 14, 73637755: 73637755

Expression for genes affiliated with Frontotemporal Dementia

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Expression patterns in normal tissues for genes affiliated with Frontotemporal Dementia

Search GEO for disease gene expression data for Frontotemporal Dementia.

Pathways for genes affiliated with Frontotemporal Dementia

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Pathways related to Frontotemporal Dementia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0MAPT, PSEN1
2
Show member pathways
9.7RPS27A, VCP
3
Show member pathways
9.6RPS27A, CHMP2B
4
Show member pathways
Alzheimers Disease37
9.4PSEN1, MAPT, SNCA
5
Show member pathways
8.8HNRNPA2B1, FUS, HNRNPA1
68.5SNCA, SOD1, TARDBP, MAPT, PSEN1

Compounds for genes affiliated with Frontotemporal Dementia

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Sources:
44Novoseek, 24HMDB, 11DrugBank, 28IUPHAR, 61Tocris Bioscience
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Compounds related to Frontotemporal Dementia according to GeneCards/GeneDecks:

(show all 39)
idCompoundScoreTop Affiliating Genes
1spec-t4410.1PSEN1, MAPT
2thioflavin4410.0SNCA, MAPT
3tmao4410.0SNCA, MAPT
4fluorochrome449.9MAPT, RPS27A
5dicoumarol449.7RPS27A, SOD1
6glycerol44 24 1111.7PSEN1, RPS27A, MAPT
73-nitrotyrosine449.7SOD1, SNCA
8carbachol44 28 1111.7MAPT, SNCA, PSEN1
9carnosine44 2410.6SNCA, SOD1
10choline44 24 1111.6MAPT, PSEN1, SNCA
118-oxo-dg449.6SNCA, SOD1
12selegiline44 1110.5SOD1, SNCA
13thioflavine s449.5MAPT, RPS27A, SNCA
14peroxynitrite449.5SNCA, PSEN1, SOD1
15silver449.4SNCA, RPS27A, MAPT
16methionine449.4MAPT, SNCA, PSEN1
17sodium dodecylsulfate449.4SNCA, RPS27A, MAPT
18mg 13244 6110.4SNCA, RPS27A, MAPT
19superoxide44 2410.4SOD1, VCP, PSEN1, TARDBP
20lactacystin449.3MAPT, PSEN1, RPS27A, SNCA
21valine449.2RPS27A, PSEN1, MAPT, SNCA
22rotenone449.2SNCA, SOD1, RPS27A
236-hydroxydopamine449.2SNCA, SOD1, RPS27A
24glycogen44 2410.2PSEN1, SNCA, RPS27A, MAPT
25nmda44 2810.2MAPT, RPS27A, PSEN1
26levodopa44 1110.2SOD1, RPS27A, SNCA
27threonine449.1RPS27A, PSEN1, VCP, MAPT
28polysaccharide449.1SNCA, VCP, RPS27A
29formate449.0SOD1, SNCA, RPS27A, MAPT
30glutamine449.0VCP, MAPT, SNCA, RPS27A, PSEN1
31n acetylcysteine448.9SOD1, SNCA, RPS27A, MAPT
32zinc44 249.9FUS, SOD1, RPS27A, MAPT
334-hydroxynonenal44 249.7SNCA, MAPT, PSEN1, SOD1, RPS27A
34h2o2448.7SOD1, PSEN1, RPS27A, MAPT, SNCA
35arginine448.7SOD1, PSEN1, SNCA, RPS27A, MAPT
36glutamate448.7SNCA, SOD1, PSEN1, RPS27A, MAPT
37alanine448.7SNCA, SOD1, PSEN1, RPS27A, MAPT
38serine448.6RPS27A, SNCA, PSEN1, VCP, MAPT
39cysteine448.4RPS27A, SNCA, SOD1, PSEN1, GRN, MAPT

GO Terms for genes affiliated with Frontotemporal Dementia

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Cellular components related to Frontotemporal Dementia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nuclear outer membraneGO:0056409.6PSEN1, SNCA
2growth coneGO:0304269.6PSEN1, MAPT, SNCA
3rough endoplasmic reticulumGO:0057919.5SNCA, PSEN1
4axonGO:0304249.5PSEN1, SNCA, MAPT
5mitochondrionGO:0057398.5PSEN1, GRN, SNCA, CHMP2B, SOD1
6extracellular vesicular exosomeGO:0700628.3VCP, CHMP2B, RPS27A, HNRNPA1, SOD1
7cytosolGO:0058297.6RPS27A, MAPT, SOD1, VCP, CHMP2B, SNCA
8nucleusGO:0056347.1TARDBP, FUS, C9orf72, SOD1, VCP, CHMP2B
9cytoplasmGO:0057376.9FUS, SOD1, VCP, CHMP2B, SNCA, HNRNPA1

Biological processes related to Frontotemporal Dementia according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1Notch receptor processingGO:0072209.9PSEN1, RPS27A
2positive regulation of proteasomal ubiquitin-dependent protein catabolic processGO:0324369.9VCP, PSEN1
3positive regulation of receptor recyclingGO:0019219.8SNCA, PSEN1
4embryo implantationGO:0075669.6GRN, SOD1
5thymus developmentGO:0485389.4PSEN1, SOD1
6negative regulation of neuron apoptotic processGO:0435249.3SNCA, PSEN1, SOD1
7positive regulation of apoptotic processGO:0430659.2PSEN1, SOD1, RPS27A
8mRNA splicing, via spliceosomeGO:0003989.0HNRNPA2B1, FUS, HNRNPA1
9mRNA processingGO:0063978.9TARDBP, HNRNPA1, HNRNPA2B1
10RNA splicingGO:0083808.7HNRNPA1, HNRNPA2B1, TARDBP, FUS
11gene expressionGO:0104678.3FUS, RPS27A, HNRNPA1, HNRNPA2B1
12cell deathGO:0082198.3FUS, HNRNPA1, GRN, UBQLN2, TARDBP, C9orf72

Molecular functions related to Frontotemporal Dementia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein domain specific bindingGO:0199049.2SNCA, CHMP2B, VCP
2nucleotide bindingGO:0001668.3TARDBP, HNRNPA2B1, HNRNPA1, FUS
3identical protein bindingGO:0428028.3FUS, SOD1, VCP, SNCA, TARDBP
4RNA bindingGO:0037238.1TARDBP, HNRNPA2B1, HNRNPA1, FUS
5poly(A) RNA bindingGO:0448227.4TARDBP, GRN, HNRNPA2B1, HNRNPA1, RPS27A, VCP
6protein bindingGO:0055155.7SOD1, VCP, PSEN1, SNCA, MAPT, HNRNPA1

Products for genes affiliated with Frontotemporal Dementia

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  • Antibodies
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Sources for Frontotemporal Dementia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet