HDDD
MCID: FRN027
MIFTS: 26

Frontotemporal Dementia, Ubiquitin-Positive (HDDD) malady

Summaries for Frontotemporal Dementia, Ubiquitin-Positive

Sources:
33MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
MalaCards: Frontotemporal Dementia, Ubiquitin-Positive, also known as dementia, hereditary dysphasic disinhibition, is related to frontotemporal dementia and grn-related frontotemporal dementia. An important gene associated with Frontotemporal Dementia, Ubiquitin-Positive is SNCA (synuclein, alpha (non A4 component of amyloid precursor)), and among its related pathways are Nanog in Mammalian ESC Pluripotency and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. The compounds thioflavin and thioflavine s have been mentioned in the context of this disorder. Related mouse phenotype taste/olfaction.

Aliases & Classifications for Frontotemporal Dementia, Ubiquitin-Positive

Sources:
43NIH Rare Diseases, 22GTR, 61UMLS
See all sources

Aliases & Descriptions:

frontotemporal dementia, ubiquitin-positive 43 22 61
dementia, hereditary dysphasic disinhibition 43
hddd 43


Related Diseases for Frontotemporal Dementia, Ubiquitin-Positive

Sources:
17GeneCards, 18GeneDecks
See all sources

Graphical network of the top 20 diseases related to Frontotemporal Dementia, Ubiquitin-Positive:



Diseases related to frontotemporal dementia, ubiquitin-positive

Clinical Features for Frontotemporal Dementia, Ubiquitin-Positive

Drugs & Therapeutics for Frontotemporal Dementia, Ubiquitin-Positive

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Frontotemporal Dementia, Ubiquitin-Positive

Drug clinical trials:

Search ClinicalTrials for Frontotemporal Dementia, Ubiquitin-Positive

Search NIH Clinical Center for Frontotemporal Dementia, Ubiquitin-Positive

Search CenterWatch for Frontotemporal Dementia, Ubiquitin-Positive

Genetic Tests for Frontotemporal Dementia, Ubiquitin-Positive

Sources:
22GTR
See all sources

Genetic tests related to Frontotemporal Dementia, Ubiquitin-Positive:

id Genetic test Affiliating Genes
1 Frontotemporal Dementia, Ubiquitin-positive22

Anatomical Context for Frontotemporal Dementia, Ubiquitin-Positive

Animal Models for Frontotemporal Dementia, Ubiquitin-Positive or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Frontotemporal Dementia, Ubiquitin-Positive:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053949.1MAPT, SNCA

Publications for Frontotemporal Dementia, Ubiquitin-Positive

Sources:
51PubMed
See all sources

Articles related to Frontotemporal Dementia, Ubiquitin-Positive:

idTitleAuthorsYear
1
Progranulin mutations in ubiquitin-positive frontotemporal dementia linked to chromosome 17q21. (17168647)
2006
2
Ubiquitin-positive inclusions and progression of pathology in frontotemporal dementia and motor neurone disease identifies a group with mainly early pathology. (16409556)
2006
3
Ubiquitin-positive frontotemporal lobar degeneration presenting with progressive Gogi (word-meaning) aphasia. A neuropsychological, radiological and pathological evaluation of a Japanese semantic dementia patient. (17045299)
2006
4
Null mutations in progranulin cause ubiquitin-positive frontotemporal dementia linked to chromosome 17q21. (16862115)
2006
5
Cortical ubiquitin-positive inclusions in frontotemporal dementia without motor neuron disease: a quantitative immunocytochemical study. (15170577)
2004
6
Familial frontotemporal dementia: a report of three cases of severe cerebral atrophy with rare inclusions that are negative for tau and synuclein, but positive for ubiquitin. (15108011)
2004
7
Frontotemporal dementia with cerebral intraneuronal ubiquitin-positive inclusions but lacking lower motor neuron involvement. (12471466)
2003
8
Ubiquitin-positive neuronal and tau 2-positive glial inclusions in frontotemporal dementia of motor neuron type. (12012092)
2002
9
Familial frontotemporal dementia with ubiquitin-positive inclusions is linked to chromosome 17q21-22. (11571213)
2001

Genetic Variations for Frontotemporal Dementia, Ubiquitin-Positive

Expression for genes affiliated with Frontotemporal Dementia, Ubiquitin-Positive

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Frontotemporal Dementia, Ubiquitin-Positive

Search GEO for disease gene expression data for Frontotemporal Dementia, Ubiquitin-Positive.

Pathways for genes affiliated with Frontotemporal Dementia, Ubiquitin-Positive

Sources:
52QIAGEN, 54Reactome, 30KEGG, 38NCBI BioSystems Database, 4Cell Signaling Technology
See all sources

Compounds for genes affiliated with Frontotemporal Dementia, Ubiquitin-Positive

Sources:
45Novoseek, 24HMDB, 29IUPHAR, 11DrugBank, 60Tocris Bioscience, 50PharmGKB
See all sources

Compounds related to Frontotemporal Dementia, Ubiquitin-Positive according to GeneCards/GeneDecks:

(show all 21)
idCompoundScoreTop Affiliating Genes
1thioflavin459.5SNCA, MAPT
2thioflavine s459.5SNCA, MAPT
3tmao459.5SNCA, MAPT
4formate459.5SNCA, MAPT
54-hydroxynonenal45 2410.4SNCA, MAPT
6silver459.4MAPT, SNCA
7lactacystin459.4SNCA, MAPT
8sodium dodecylsulfate459.4SNCA, MAPT
9carbachol45 29 1111.4MAPT, SNCA
10mg 13245 6010.4SNCA, MAPT
11choline45 11 2411.4MAPT, SNCA
12valine459.4MAPT, SNCA
13phosphatidylserine45 29 1111.3SNCA, MAPT
14n acetylcysteine459.3MAPT, SNCA
15methionine459.3MAPT, SNCA
16acetylcholine45 50 29 11 2413.2MAPT, SNCA
17glycogen45 2410.2SNCA, MAPT
18paraffin459.1MAPT, SNCA
19heparin45 29 11 2412.1MAPT, SNCA
20glutamine459.0SNCA, MAPT
21dopamine45 29 11 2411.8MAPT, SNCA

GO Terms for genes affiliated with Frontotemporal Dementia, Ubiquitin-Positive

Sources:
16Gene Ontology
See all sources

Cellular components related to Frontotemporal Dementia, Ubiquitin-Positive according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1axonGO:0304249.1MAPT, SNCA
2growth coneGO:0304268.8MAPT, SNCA

Molecular functions related to Frontotemporal Dementia, Ubiquitin-Positive according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1microtubule bindingGO:0080179.1MAPT, SNCA

Products for genes affiliated with Frontotemporal Dementia, Ubiquitin-Positive

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Frontotemporal Dementia, Ubiquitin-Positive

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet