HDDD
MCID: FRN027
MIFTS: 25

Frontotemporal Dementia, Ubiquitin-Positive (HDDD) malady

Summaries for Frontotemporal Dementia, Ubiquitin-Positive

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32MalaCards
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MalaCards: Frontotemporal Dementia, Ubiquitin-Positive, also known as dementia, hereditary dysphasic disinhibition, is related to frontotemporal dementia and grn-related frontotemporal dementia. An important gene associated with Frontotemporal Dementia, Ubiquitin-Positive is SNCA (synuclein, alpha (non A4 component of amyloid precursor)), and among its related pathways are Nanog in Mammalian ESC Pluripotency and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. The compounds thioflavin and thioflavine s have been mentioned in the context of this disorder. Related mouse phenotype taste/olfaction.

Aliases & Classifications for Frontotemporal Dementia, Ubiquitin-Positive

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42NIH Rare Diseases, 22GTR, 60UMLS
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Aliases & Descriptions:

frontotemporal dementia, ubiquitin-positive 42 22 60
dementia, hereditary dysphasic disinhibition 42
hddd 42


Related Diseases for Frontotemporal Dementia, Ubiquitin-Positive

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Frontotemporal Dementia, Ubiquitin-Positive:



Diseases related to frontotemporal dementia, ubiquitin-positive

Clinical Features for Frontotemporal Dementia, Ubiquitin-Positive

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Drugs & Therapeutics for Frontotemporal Dementia, Ubiquitin-Positive

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Frontotemporal Dementia, Ubiquitin-Positive

Search CenterWatch for Frontotemporal Dementia, Ubiquitin-Positive

Genetic Tests for Frontotemporal Dementia, Ubiquitin-Positive

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22GTR
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Genetic tests related to Frontotemporal Dementia, Ubiquitin-Positive:

id Genetic test Affiliating Genes
1 Frontotemporal Dementia, Ubiquitin-Positive22

Anatomical Context for Frontotemporal Dementia, Ubiquitin-Positive

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Animal Models for Frontotemporal Dementia, Ubiquitin-Positive or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Frontotemporal Dementia, Ubiquitin-Positive:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053949.1MAPT, SNCA

Publications for Frontotemporal Dementia, Ubiquitin-Positive

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Genetic Variations for Frontotemporal Dementia, Ubiquitin-Positive

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Expression for genes affiliated with Frontotemporal Dementia, Ubiquitin-Positive

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Frontotemporal Dementia, Ubiquitin-Positive

Search GEO for disease gene expression data for Frontotemporal Dementia, Ubiquitin-Positive.

Pathways for genes affiliated with Frontotemporal Dementia, Ubiquitin-Positive

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Sources:
51QIAGEN, 53Reactome, 29KEGG, 37NCBI BioSystems Database, 4Cell Signaling Technology
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Compounds for genes affiliated with Frontotemporal Dementia, Ubiquitin-Positive

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44Novoseek, 24HMDB, 28IUPHAR, 11DrugBank, 59Tocris Bioscience, 49PharmGKB
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Compounds related to Frontotemporal Dementia, Ubiquitin-Positive according to GeneCards/GeneDecks:

(show all 21)
idCompoundScoreTop Affiliating Genes
1thioflavin449.5MAPT, SNCA
2thioflavine s449.5MAPT, SNCA
3tmao449.5SNCA, MAPT
4formate449.5MAPT, SNCA
5silver449.4SNCA, MAPT
64-hydroxynonenal44 2410.4SNCA, MAPT
7lactacystin449.4MAPT, SNCA
8sodium dodecylsulfate449.4SNCA, MAPT
9carbachol44 28 1111.4MAPT, SNCA
10mg 13244 5910.4MAPT, SNCA
11choline44 11 2411.4SNCA, MAPT
12valine449.4MAPT, SNCA
13phosphatidylserine44 28 1111.3MAPT, SNCA
14n acetylcysteine449.3SNCA, MAPT
15methionine449.3MAPT, SNCA
16acetylcholine44 49 28 11 2413.2SNCA, MAPT
17glycogen44 2410.2MAPT, SNCA
18paraffin449.1MAPT, SNCA
19heparin44 28 11 2412.1MAPT, SNCA
20glutamine449.0SNCA, MAPT
21dopamine44 28 11 2411.8MAPT, SNCA

GO Terms for genes affiliated with Frontotemporal Dementia, Ubiquitin-Positive

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16Gene Ontology
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Cellular components related to Frontotemporal Dementia, Ubiquitin-Positive according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1axonGO:0304249.1MAPT, SNCA
2growth coneGO:0304268.8MAPT, SNCA

Molecular functions related to Frontotemporal Dementia, Ubiquitin-Positive according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1microtubule bindingGO:0080179.1MAPT, SNCA

Products for genes affiliated with Frontotemporal Dementia, Ubiquitin-Positive

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Frontotemporal Dementia, Ubiquitin-Positive

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet