Frontotemporal Lobar Degeneration with Ubiquitin-positive Inclusions malady

MalaCards: Frontotemporal Lobar Degeneration with Ubiquitin-positive Inclusions, also known as frontotemporal lobar degeneration, is related to lateral sclerosis and neuronitis. An important gene associated with Frontotemporal Lobar Degeneration with Ubiquitin-positive Inclusions is LOC643387 (TAR DNA binding protein pseudogene).

OMIM: 607485

frontotemporal lobar degeneration with ubiquitin-positive inclusions 33 frontotemporal lobar degeneration 43

Diseases related to frontotemporal lobar degeneration with ubiquitin-positive inclusions by text searches and GeneDecks gene sharing:

(show all 45)

id	Related Disease	Score	Top Affiliating Genes
1	lateral sclerosis	32.5	GRN, RPS27A, SQSTM1, LOC643387, TARDBP
2	neuronitis	32.3	LOC643387, SQSTM1, RPS27A, TARDBP, GRN
3	amyotrophic lateral sclerosis	32.3	RPS27A, LOC643387, GRN, TARDBP, SQSTM1
4	motor neuron disease	31.3	GRN, LOC643387, TARDBP, SQSTM1, RPS27A
5	alzheimer's disease	31.2	SQSTM1, LOC643387, GRN, TARDBP, RPS27A
6	frontotemporal dementia	30.6	SQSTM1, LOC643387, RPS27A, GRN, TARDBP
7	dementia	30.0	LOC643387, RPS27A, TARDBP, SQSTM1, GRN
8	semantic dementia	29.7	TARDBP, GRN, RPS27A
9	paralysis	29.5	RPS27A, TARDBP
10	parkinson's disease	27.8	TARDBP, RPS27A, LOC643387, GRN, SQSTM1
11	tauopathy	12.7	RPS27A, GRN
12	perry syndrome	12.7	GRN, TARDBP
13	lewy body dementia	12.7	RPS27A, GRN
14	primary progressive aphasia	12.7	GRN, TARDBP
15	corticobasal degeneration	12.7	TARDBP, RPS27A
16	inclusion body myopathy	12.6	TARDBP, RPS27A
17	spinocerebellar ataxia type 3	12.6	RPS27A, TARDBP
18	chorea	12.6	RPS27A, TARDBP
19	myofibrillar myopathy	12.5	RPS27A, SQSTM1
20	alcoholic hepatitis	12.4	RPS27A, SQSTM1
21	paget's disease of bone	12.4	RPS27A, SQSTM1
22	olivopontocerebellar atrophy	12.3	RPS27A, TARDBP
23	inclusion body myositis	12.3	SQSTM1, RPS27A
24	prion disease	12.3	SQSTM1, RPS27A
25	multiple system atrophy	12.2	RPS27A, SQSTM1
26	amyotrophic lateral sclerosis with frontotemporal dementia	12.2	TARDBP, RPS27A, GRN
27	aphasia	12.2	GRN, RPS27A, TARDBP
28	traumatic brain injury	12.2	TARDBP, GRN, RPS27A
29	polymyositis	12.1	RPS27A, SQSTM1
30	brain injury	12.1	TARDBP, GRN, RPS27A
31	neurodegeneration	12.0	RPS27A, GRN, TARDBP
32	myositis	11.8	SQSTM1, RPS27A, TARDBP
33	galactosemia	11.5	RPS27A, GRN, SQSTM1
34	neurodegenerative disease	11.4	TARDBP, RPS27A, GRN, SQSTM1
35	pick's disease	11.0	TARDBP, LOC643387, GRN, SQSTM1, RPS27A
36	frontotemporal lobar degeneration, tardbp-related	9.0
37	grn-related frontotemporal dementia	8.5
38	was-related disorders	8.5
39	amyloidosis	7.6
40	cerebritis	7.6
41	progressive supranuclear palsy	7.6
42	progressive non-fluent aphasia	7.6
43	supranuclear palsy	7.6
44	spastic paralysis	7.6
45	spasticity	7.6

Clinical features from OMIM: 607485

Approved drugs:

Drug clinical trials:

Articles related to frontotemporal lobar degeneration with ubiquitin-positive inclusions:

id	Title	Authors	Year	Affiliating Genes
1	Neuropathologic features of frontotemporal lobar degeneration with ubiquitin-positive inclusions visualized with ubiquitin-binding protein p62 immunohistochemistry. (18379439)	Pikkarainen M.... Alafuzoff I.	2008	SQSTM1, TARDBP
2	Neuropathologic features of frontotemporal lobar degeneration with ubiquitin-positive inclusions with progranulin gene (PGRN) mutations. (17278999)	Josephs K.A.... Dickson D.W.	2007	GRN, RPS27A
3	Appearance pattern of TDP-43 in Japanese frontotemporal lobar degeneration with ubiquitin-positive inclusions. (17507161)	Higashi S.... Arai H.	2007	TARDBP
4	Voxel-based morphometry in frontotemporal lobar degeneration with ubiquitin-positive inclusions with and without progranulin mutations. (17353379)	Whitwell J.L.... Josephs K.A.	2007	GRN
5	Neuropathologic heterogeneity in HDDD1: a familial frontotemporal lobar degeneration with ubiquitin-positive inclusions and progranulin mutation. (17334266)	Behrens M.I.... Cairns N.J.	2007	GRN
6	TDP-43 pathologic lesions and clinical phenotype in frontotemporal lobar degeneration with ubiquitin-positive inclusions. (17923628)	Grossman M.... Trojanowski J.Q.	2007	LOC643387

Genes related to frontotemporal lobar degeneration with ubiquitin-positive inclusions according to GeneCards:

id	Symbol	Description	Score	GeneCards Section Context
1	LOC643387	TAR DNA binding protein pseudogene	11.1	Publications
2	GRN	granulin	11.1	Publications
3	TARDBP	TAR DNA binding protein	11.1	Publications
4	SQSTM1	sequestosome 1	11.1	Publications
5	RPS27A	ribosomal protein S27a	11.1	Publications

Biological processes related to frontotemporal lobar degeneration with ubiquitin-positive inclusions according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	induction of apoptosis by extracellular signals	GO:008624	9.1	RPS27A, SQSTM1
2	endosomal transport	GO:016197	8.8	RPS27A, SQSTM1