MCID: FRZ001
MIFTS: 45

Frozen Shoulder malady

Summaries for Frozen Shoulder

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Frozen shoulder, medically referred to as adhesive capsulitis, is a disorder in which the shoulder... more...

MalaCards: Frozen Shoulder, also known as adhesive capsulitis of shoulder, is related to osteoarthritis and tendinitis. An important gene associated with Frozen Shoulder is LHB (luteinizing hormone beta polypeptide), and among its related pathways are Advanced glycosylation endproduct receptor signaling and Angiogenesis. The compounds butyrate and ilomastat have been mentioned in the context of this disorder. Affiliated tissues include skin and endothelial, and related mouse phenotypes are tumorigenesis and nervous system.

Aliases & Classifications for Frozen Shoulder

Sources:
8Disease Ontology, 10DISEASES, 61UMLS, 57SNOMED-CT, 35MeSH, 27ICD9CM, 25ICD10
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Classifications:



Aliases & Descriptions:

frozen shoulder 8 10 61
adhesive capsulitis of shoulder 8
adhesions-capsulitis,shoulder 8


External Ids:

Disease Ontology8 DOID:14188
MeSH35 D002062
ICD9CM27 726.0
ICD1025 M75.0

Related Diseases for Frozen Shoulder

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Frozen Shoulder via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 100)
idRelated DiseaseScoreTop Affiliating Genes
1osteoarthritis30.1ACRV1, COL1A1, ITGB1, MAPK1, MMP3, MAPK8
2tendinitis10.6
3calcific tendinitis10.5
4n syndrome10.5
5parkinson's disease10.3
6tuberculosis10.3
7pulmonary tuberculosis10.1
8short syndrome10.1
9isolated acth deficiency10.1
10acth deficiency10.1
11autonomic dysfunction10.1
12familial dupuytren contracture10.1
13multiple myeloma10.0CD40
14cervical cancer10.0CD40
15kawasaki disease10.0MMP3
16dementia10.0MMP3
17acute myocardial infarction10.0CD40
18hordeolum10.0ACRV1
19hemangiopericytoma10.0S100B
20connective tissue disease10.0CD40
21macroglobulinemia, waldenstrom, somatic10.0CD40
22dermatofibrosarcoma10.0COL1A1
23sjogren's syndrome10.0CD40
24hepatitis c10.0ITGB1
25cholesteatoma10.0MMP3
26uveitis10.0HLA-B
27thyroid cancer10.0MAPK1
28rhabdomyosarcoma10.0S100B
29bladder carcinoma10.0HLA-B
30vaccinia10.0HLA-B
31meningitis10.0HLA-B
32adenoma10.0HLA-B
33infertility10.0ITGB1
34hepatitis10.0HLA-B
35nephritis10.0ITGB1
36leiomyoma10.0S100B, MMP3
37glomerulonephritis10.0ITGB1
38dermatofibrosarcoma protuberans10.0S100B, COL1A1
39encephalitis10.0HLA-B
40influenza10.0HLA-B
41synovitis10.0ITGB1, MMP3
42letterer-siwe disease10.0S100B, CD40
43hepatitis b10.0HLA-B, MMP3
44multiple sclerosis10.0CD40, HLA-B
45pneumonia10.0MAPK8, CD40
46pulmonary fibrosis10.0COL1A1, MAPK8
47cystic fibrosis10.0MAPK8, CD40
48vasculitis10.0ITGB1, HLA-B
49keratitis10.0VEGFA
50polymyositis10.0HLA-B, CD40

Graphical network of the top 20 diseases related to Frozen Shoulder:



Diseases related to frozen shoulder

Clinical Features for Frozen Shoulder

Drugs & Therapeutics for Frozen Shoulder

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Frozen Shoulder

Drug clinical trials:

Search ClinicalTrials for Frozen Shoulder

Search NIH Clinical Center for Frozen Shoulder

Search CenterWatch for Frozen Shoulder

Genetic Tests for Frozen Shoulder

Anatomical Context for Frozen Shoulder

Sources:
33MalaCards
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MalaCards organs/tissues related to Frozen Shoulder:

33
Skin, Endothelial

Animal Models for Frozen Shoulder or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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Publications for Frozen Shoulder

Sources:
51PubMed
See all sources

Articles related to Frozen Shoulder:

(show top 50)    (show all 332)
idTitleAuthorsYear
1
Frozen shoulder and the Big Five personality traits. (24090979)
2014
2
Comparative study of the clinical efficacy of the selective cyclooxygenase-2 inhibitor celecoxib compared with loxoprofen in patients with frozen shoulder. (24261771)
2014
3
Motion and pain relief remain 23 years after manipulation under anesthesia for frozen shoulder. (22907476)
2013
4
The effectiveness of physiotherapeutic interventions in treatment of frozen shoulder/adhesive capsulitis: A systematic review. (24284277)
2013
5
Frozen shoulder: what can a physical therapist do for my painful and stiff shoulder? (23635383)
2013
6
Comparison between NSAID and intra-articular corticosteroid injection in frozen shoulder of diabetic patients; a randomized clinical trial. (23426700)
2013
7
Shoulder muscle isometric strength and active range of motion in patients with frozen shoulder syndrome after manipulation under anesthesia. (23032904)
2012
8
Chiropractic management of frozen shoulder syndrome using a novel technique: a retrospective case series of 50 patients. (23843759)
2012
9
Treatment of frozen shoulder with intra-articular injection of botulinum toxin in shoulder joints. (21640488)
2011
10
What is frozen shoulder? (21124270)
2011
11
Serum triglyceride level in type 2 diabetes mellitus patients with or without frozen shoulder. (21473204)
2010
12
Treating frozen shoulder with ultrasound-guided pulsed mode radiofrequency lesioning of the suprascapular nerve: two cases. (21040432)
2010
13
How to release a frozen shoulder. Simple activities like fastening a bra or taking a book off an overhead shelf can be impossible when you have a frozen shoulder. (21140552)
2010
14
A study on Apabahuka (frozen shoulder) and its management by Laghumasha taila nasya. (22048545)
2010
15
Shoulder kinematic features using arm elevation and rotation tests for classifying patients with frozen shoulder syndrome who respond to physical therapy. (17913564)
2008
16
Effectiveness of electroacupuncture and interferential eloctrotherapy in the management of frozen shoulder. (18292916)
2008
17
Treatment for frozen shoulder combined with calcific tendinitis of the supraspinatus. (18281224)
2008
18
Manipulation under anesthesia with home exercises versus home exercises alone in the treatment of frozen shoulder: a randomized, controlled trial with 125 patients. (17931902)
2007
19
Shoulder muscle strength and fatigability in patients with frozen shoulder syndrome: the effect of 4-week individualized rehabilitation. (17711038)
2007
20
Enhanced alpha 1(I) mRNA expression in frozen shoulder and dupuytren tissue. (18024269)
2007
21
Comparison of idiopathic, post-trauma and post-surgery frozen shoulder after manipulation under anesthesia. (16927088)
2007
22
Intraarticular lesions in primary frozen shoulder after manipulation under general anesthesia. (15723009)
2005
23
Frozen shoulder. (15858111)
2005
24
Arthrographic distension of the shoulder joint in the management of frozen shoulder. (15695959)
2005
25
Frozen shoulder. (15834069)
2005
26
A capsular dilatation facilitated shoulder manipulation for treating patients with frozen shoulder. (12188408)
2002
27
Idiopathic frozen shoulder treated by arthroscopic brisement. (12355929)
2002
28
Clients' experiences of frozen shoulder and its treatment with Bowen technique. (12463610)
2002
29
The association between frozen shoulder and Dupuytren's disease. (11307078)
2001
30
Frozen shoulder in identical twins. (10773973)
2000
31
Exercising the frozen shoulder. (20086661)
2000
32
Frozen shoulder: a sympathetic dystrophy? (10653111)
2000
33
Frozen shoulder syndrome associated with subpectoral defibrillator implantation. (10490482)
1999
34
Local corticosteroid injections in the treatment of rotator cuff tendinitis (except for frozen shoulder and calcific tendinitis). Groupe Rhumatologique FranAsais de l'Epaule (G.R.E.P.). (8913661)
1996
35
Chiropractic treatment of frozen shoulder syndrome (adhesive capsulitis) utilizing mechanical force, manually assisted short lever adjusting procedures. (7790781)
1995
36
Primary chest wall tumor appearing as frozen shoulder. Review and case presentations. (1895276)
1991
37
Office management of frozen shoulder syndrome. Treatment with hydraulic distension under local anesthesia. (2706848)
1989
38
Frozen shoulder: prospective clinical study with an evaluation of three treatment regimens. (6742895)
1984
39
Frozen shoulder (adhesive capsulitis) (7120251)
1982
40
The frozen shoulder: a review of manipulative treatment. (7414187)
1980
41
The frozen shoulder. Clinical and radiographical observations. The effect of manipulation under general anesthesia. Structure and glycosaminoglycan content of the joint capsule. Local bone metabolism. (4245631)
1969
42
DMSO an adjutant to physical therapy in the chronic frozen shoulder. (4167319)
1967
43
"FROZEN SHOULDER". EVALUATION OF TREATMENT WITH HYDROCORTISONE INJECTIONS AND EXERCISES. (14259230)
1965
44
Some tumors about the shoulder joint with early manifestations simulating frozen shoulder. (13976406)
1963
45
Thawing the frozen shoulder. (13561596)
1958
46
Brachial palsy after manipulation of frozen shoulder. (13144973)
1954
47
The frozen shoulder; treatment by manipulation. (14812093)
1951
48
ACTH and cortisone in periarthritis of the shoulder ("frozen shoulder"). (14895099)
1951
49
Shoulder pain with particular reference to the frozen shoulder. (18142155)
1949
50
The frozen shoulder. (18153629)
1949

Genetic Variations for Frozen Shoulder

Expression for genes affiliated with Frozen Shoulder

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Frozen Shoulder

Search GEO for disease gene expression data for Frozen Shoulder.

Pathways for genes affiliated with Frozen Shoulder

Sources:
54Reactome, 38NCBI BioSystems Database, 56SinoBiological, 53R&D Systems, 12EMD Millipore, 30KEGG, 50PharmGKB, 52QIAGEN
See all sources

Pathways related to Frozen Shoulder according to GeneCards/GeneDecks:

(show all 41)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8S100B, MAPK1
29.7MAPK1, VEGFA
39.7MAPK8, CD40
49.6MAPK8, MAPK1
59.3ITGB1, COL1A1
6
Hide members
9.3CD40, MAPK8, MAPK1
79.3CD40, MAPK8, MAPK1
89.3ITGB1, MAPK1
9
G-protein signaling Ras family GTPases in kinase cascades (scheme)
Hide members
9.3MMP3, MAPK1, MAPK8
109.3MAPK1, MMP3, MAPK8
11
Hide members
9.2VEGFA, MAPK1, MAPK8
12
Hide members
9.2MAPK1, MAPK8, VEGFA
13
Hide members
9.2MAPK1, MAPK8, VEGFA
14
Cell adhesion ECM remodeling
Hide members
9.0ITGB1, COL1A1, MMP3
159.0ITGB1, MAPK1, COL1A1
168.9HLA-B, ITGB1, CD40
17
Hide members
8.8MAPK8, ITGB1, MAPK1
188.8MAPK8, ITGB1, MAPK1
19
Development PDGF signaling via STATs and NF-kB
Hide members
8.8ITGB1, MAPK8, MAPK1
208.8MAPK1, MAPK8, ITGB1
218.8ITGB1, MAPK1, MAPK8
228.8MAPK1, MAPK8, ITGB1
238.8ITGB1, MAPK8, MAPK1
24
Hide members
8.8MAPK1, ITGB1, MAPK8
25
Hide members
8.7HLA-B, VEGFA, MAPK1, MAPK8
26
Hide members
8.7ITGB1, LHB, MAPK1, COL1A1
278.5VEGFA, ITGB1, MAPK1, COL1A1
28
Hide members
8.5COL1A1, ITGB1, VEGFA, MAPK1
29
Development Prolactin receptor signaling
Hide members
8.5ITGB1, MAPK1, MAPK8, LHB
30
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8.5CD40, MAPK1, MAPK8, ITGB1
31
Hide members
8.4MAPK8, ITGB1, COL1A1, MAPK1
32
Hide members
8.3ITGB1, VEGFA, MAPK1, MAPK8
33
Translation Insulin regulation of translation
Hide members
8.3ITGB1, MAPK8, MAPK1, VEGFA
34
Hide members
8.3MAPK1, MAPK8, VEGFA, ITGB1
358.3MAPK1, VEGFA, MAPK8, ITGB1
36
Hide members
8.2ITGB1, MAPK8, MMP3, MAPK1, LHB
37
Hide members
8.0VEGFA, MAPK1, COL1A1, ITGB1, MAPK8
38
Hide members
7.9LHB, ITGB1, MAPK8, MAPK1, COL1A1, MMP3
39
Development Endothelin-1/EDNRA signaling
Hide members
7.8LHB, ITGB1, VEGFA, MAPK8, COL1A1, MAPK1
40
Hide members
7.7MAPK8, MAPK1, CD40, S100B, HLA-B, ITGB1
41
Hide members
7.2COL1A1, LHB, S100B, ITGB1, VEGFA, MAPK8

Compounds for genes affiliated with Frozen Shoulder

Sources:
45Novoseek, 2BitterDB, 11DrugBank, 60Tocris Bioscience, 50PharmGKB, 29IUPHAR, 24HMDB
See all sources

Compounds related to Frozen Shoulder according to GeneCards/GeneDecks:

(show top 50)    (show all 76)
idCompoundScoreTop Affiliating Genes
1butyrate4510.4CD40
2ilomastat4510.4MMP3
3pge24510.2COL1A1, VEGFA
41,4-diamino-2,3-dicyano-1,4-bis(2-aminophenylthio)butadiene459.9MAPK8, MAPK1
53-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide459.9CD40, S100B, MAPK1
6magnolol459.8MAPK8, MAPK1
7ecori459.8COL1A1, S100B, HLA-B
8nobiletin459.7MAPK8, MAPK1
9hcec459.7MMP3, MAPK1, MAPK8
104-amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine459.6MAPK1, MAPK8
11chloramphenicol45 2 1111.6S100B, CD40, MMP3, COL1A1
12pd 169316459.6VEGFA, MAPK8, MAPK1
13ag-126459.6MAPK8, MAPK1
14ro 31 8220459.6MAPK8, MAPK1, VEGFA
15pd153035459.6VEGFA, MAPK1, MAPK8
16apocynin45 6010.5VEGFA, MAPK8, MAPK1
17simvastatin45 50 60 29 11 2414.5CD40, MMP3, VEGFA, COL1A1
18ns 39845 6010.5MAPK1, MAPK8, VEGFA
19ang ii459.5MAPK1, MAPK8, VEGFA
20diphenyleneiodonium459.5MAPK1, VEGFA, MAPK8
2115-deoxy-delta-12,14-prostaglandin j2459.4MAPK1, MAPK8, VEGFA
22ribonucleic acid459.4HLA-B, CD40, COL1A1, MMP3
23paclitaxel45 50 1111.3MAPK1, VEGFA, MAPK8, S100B
24celecoxib45 60 29 50 11 2414.3VEGFA, MAPK8, MAPK1, MMP3
25curcumin459.2MMP3, MAPK1, MAPK8, VEGFA
26herbimycin a45 6010.2MAPK8, CD40, ITGB1
27rapamycin459.1MAPK1, VEGFA, MAPK8, CD40
28triptolide459.0MAPK8, MAPK1, CD40, MMP3, VEGFA
29imatinib45 50 1111.0MAPK1, VEGFA, S100B, COL1A1, MAPK8
30oxygen45 2410.0MAPK8, S100B, CD40, ITGB1
31n acetylcysteine459.0VEGFA, MAPK8, MAPK1, CD40, MMP3
32ly294002459.0VEGFA, MAPK8, MAPK1, CD40
33sp 60012545 609.9MAPK8, CD40, MAPK1, ITGB1
34matrigel458.9ITGB1, MAPK1, VEGFA, MMP3
35zinc45 249.7S100B, HLA-B, CD40, MMP3, COL1A1
36thymidine45 249.7S100B, MAPK1, CD40, COL1A1, ITGB1
37cyclosporin a45 29 6010.7CD40, HLA-B, MMP3, S100B, ITGB1
3812-o-tetradecanoylphorbol 13-acetate458.6MAPK1, ITGB1, MAPK8, MMP3, CD40
39actinomycin d458.6CD40, MAPK1, MAPK8, VEGFA
40wortmannin458.6CD40, MAPK8, S100B, ITGB1, MAPK1
41pd 98,059458.6MMP3, MAPK1, MAPK8, ITGB1, CD40
42serine458.5S100B, HLA-B, ITGB1, MAPK8, MMP3
43paraffin458.4VEGFA, S100B, HLA-B, MMP3, CD40, ITGB1
44nitric oxide45 11 2410.3ITGB1, S100B, HLA-B, MAPK1, CD40
45dexamethasone45 50 29 1111.2MAPK1, COL1A1, S100B, ITGB1, VEGFA, MAPK8
46sb 20358045 609.2MAPK1, VEGFA, ITGB1, MAPK8, MMP3, CD40
47genistein45 29 60 2 11 2413.2MMP3, MAPK1, MAPK8, VEGFA, ITGB1, CD40
48vegf457.6ITGB1, MMP3, CD40, MAPK1, MAPK8, VEGFA
49retinoic acid45 248.6CD40, MAPK1, MAPK8, ITGB1, HLA-B, S100B
50tyrosine457.4S100B, CD40, MMP3, MAPK1, VEGFA, ITGB1

GO Terms for genes affiliated with Frozen Shoulder

Sources:
16Gene Ontology
See all sources

Cellular components related to Frozen Shoulder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.6MMP3, CD40, VEGFA, S100B, LHB, COL1A1

Biological processes related to Frozen Shoulder according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of protein kinase C signaling cascadeGO:0900379.9VEGFA, CD40
2platelet activationGO:0301689.2CD40, MAPK1, VEGFA, COL1A1
3cell migration involved in sprouting angiogenesisGO:0020429.1VEGFA, ITGB1
4regulation of immune responseGO:0507768.9CD40, ITGB1, HLA-B
5cellular response to mechanical stimulusGO:0712608.7CD40, MAPK8, ITGB1, COL1A1
6positive regulation of cell migrationGO:0303358.7COL1A1, ITGB1, VEGFA, MAPK1
7blood coagulationGO:0075968.5MAPK1, VEGFA, ITGB1, COL1A1
8positive regulation of cell proliferationGO:0082848.3S100B, ITGB1, VEGFA, MAPK1

Molecular functions related to Frozen Shoulder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1fibronectin bindingGO:0019689.2VEGFA, ITGB1

Products for genes affiliated with Frozen Shoulder

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Frozen Shoulder

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet