MCID: FRZ001
MIFTS: 49

Frozen Shoulder malady

Summaries for Frozen Shoulder

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63Wikipedia, 32MalaCards
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Wikipedia:63 Frozen shoulder, medically referred to as adhesive capsulitis, is a disorder in which the shoulder... more...

MalaCards: Frozen Shoulder, also known as adhesive capsulitis of shoulder, is related to diabetes mellitus and osteoarthritis. An important gene associated with Frozen Shoulder is LHB (luteinizing hormone beta polypeptide), and among its related pathways are Advanced glycosylation endproduct receptor signaling and Angiogenesis. The compounds butyrate and ilomastat have been mentioned in the context of this disorder. Affiliated tissues include bone, skin and testes, and related mouse phenotypes are tumorigenesis and nervous system.

Aliases & Classifications for Frozen Shoulder

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8Disease Ontology, 10DISEASES, 60UMLS, 56SNOMED-CT, 34MeSH, 27ICD9CM, 25ICD10
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Classifications:



Aliases & Descriptions:

frozen shoulder 8 10 60
adhesive capsulitis of shoulder 8
adhesions-capsulitis,shoulder 8


External Ids:

Disease Ontology8 DOID:14188
MeSH34 D002062
ICD9CM27 726.0
ICD1025 M75.0

Related Diseases for Frozen Shoulder

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17GeneCards, 18GeneDecks
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Diseases related to Frozen Shoulder via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 99)
idRelated DiseaseScoreTop Affiliating Genes
1diabetes mellitus30.5HLA-B, VEGFA, MAPK8, MMP3
2osteoarthritis30.0COL1A1, ITGB1, MAPK8, MAPK1, MMP3, ACRV1
3tendinitis10.5
4calcific tendinitis10.5
5parkinson's disease10.2
6tuberculosis10.2
7pulmonary tuberculosis10.1
8neuronitis10.1
9cervicitis10.1
10gallbladder cancer10.1
11hyperthyroidism10.1
12type 2 diabetes mellitus10.1
13familial dupuytren contracture10.1
14multiple myeloma10.0CD40
15cervical cancer10.0CD40
16kawasaki disease10.0MMP3
17dementia10.0MMP3
18acute myocardial infarction10.0CD40
19hordeolum10.0ACRV1
20hemangiopericytoma10.0S100B
21connective tissue disease10.0CD40
22macroglobulinemia, waldenstrom, somatic10.0CD40
23dermatofibrosarcoma10.0COL1A1
24sjogren's syndrome10.0CD40
25hepatitis c10.0ITGB1
26cholesteatoma10.0MMP3
27uveitis10.0HLA-B
28thyroid cancer10.0MAPK1
29rhabdomyosarcoma10.0S100B
30bladder carcinoma10.0HLA-B
31vaccinia10.0HLA-B
32meningitis10.0HLA-B
33adenoma10.0HLA-B
34infertility10.0ITGB1
35hepatitis10.0HLA-B
36nephritis10.0ITGB1
37leiomyoma10.0MMP3, S100B
38glomerulonephritis10.0ITGB1
39dermatofibrosarcoma protuberans10.0COL1A1, S100B
40encephalitis10.0HLA-B
41influenza10.0HLA-B
42synovitis10.0MMP3, ITGB1
43letterer-siwe disease10.0CD40, S100B
44hepatitis b10.0MMP3, HLA-B
45multiple sclerosis10.0CD40, HLA-B
46pneumonia10.0CD40, MAPK8
47pulmonary fibrosis10.0MAPK8, COL1A1
48cystic fibrosis10.0CD40, MAPK8
49vasculitis10.0ITGB1, HLA-B
50keratitis10.0VEGFA

Graphical network of the top 20 diseases related to Frozen Shoulder:



Diseases related to frozen shoulder

Clinical Features for Frozen Shoulder

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Drugs & Therapeutics for Frozen Shoulder

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Frozen Shoulder

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Anatomical Context for Frozen Shoulder

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32MalaCards
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MalaCards organs/tissues related to Frozen Shoulder:

32
Bone, Skin, Testes, Endothelial

Animal Models for Frozen Shoulder or affiliated genes

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36MGI
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Publications for Frozen Shoulder

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50PubMed
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Articles related to Frozen Shoulder:

(show top 50)    (show all 324)
idTitleAuthorsYear
1
Motion and pain relief remain 23 years after manipulation under anesthesia for frozen shoulder. (22907476)
2013
2
The effectiveness of physiotherapeutic interventions in treatment of frozen shoulder/adhesive capsulitis: A systematic review. (24284277)
2013
3
Effects of glycemic control on prevalence of diabetic frozen shoulder. (22617920)
2012
4
Management of frozen shoulder a89 conservative vs surgical? (21943454)
2011
5
Frozen shoulder: a consensus definition. (21051244)
2011
6
Serum triglyceride level in type 2 diabetes mellitus patients with or without frozen shoulder. (21473204)
2010
7
Treating frozen shoulder with ultrasound-guided pulsed mode radiofrequency lesioning of the suprascapular nerve: two cases. (21040432)
2010
8
Shoulder kinematic features using arm elevation and rotation tests for classifying patients with frozen shoulder syndrome who respond to physical therapy. (17913564)
2008
9
The trunk as a part of the kinematic chain for arm elevation in healthy subjects and in patients with frozen shoulder. (18164696)
2008
10
Manipulation under anesthesia did not enhance the benefit conferred by home exercises for frozen shoulder. (18676925)
2008
11
Effects of deep and superficial heating in the management of frozen shoulder. (18509580)
2008
12
Three-dimensional scapular kinematics and scapulohumeral rhythm in patients with glenohumeral osteoarthritis or frozen shoulder. (17949728)
2008
13
Manipulation under anesthesia with home exercises versus home exercises alone in the treatment of frozen shoulder: a randomized, controlled trial with 125 patients. (17931902)
2007
14
Shoulder muscle strength and fatigability in patients with frozen shoulder syndrome: the effect of 4-week individualized rehabilitation. (17711038)
2007
15
Intraarticular lesions in primary frozen shoulder after manipulation under general anesthesia. (15723009)
2005
16
Frozen shoulder. (15858111)
2005
17
Arthrographic distension of the shoulder joint in the management of frozen shoulder. (15695959)
2005
18
Frozen shoulder. (16356983)
2005
19
Shoulder function in patients with frozen shoulder before and after 4-week rehabilitation. (15687748)
2005
20
Effectiveness of hydroplasty and therapeutic exercise for treatment of frozen shoulder. (12943124)
2003
21
A capsular dilatation facilitated shoulder manipulation for treating patients with frozen shoulder. (12188408)
2002
22
Idiopathic frozen shoulder treated by arthroscopic brisement. (12355929)
2002
23
The association between frozen shoulder and Dupuytren's disease. (11307078)
2001
24
Double blind randomized clinical trial examining the efficacy of bupivacaine suprascapular nerve blocks in frozen shoulder. (10852272)
2000
25
Frozen shoulder in identical twins. (10773973)
2000
26
The Frozen Shoulder syndrome plus other evidence and the Utah Paradigm suggest the syndrome's pathogenesis and new targets for collagenous tissue research. (15758503)
2000
27
Frozen shoulder and fluoroquinones. Two case reports. (10875328)
2000
28
Thawing of frozen shoulder in menopausal women treated with a Japanese herbal medicine, Kanzo-to extract: report of two cases. (10758790)
2000
29
Bilateral frozen shoulder associated with a three-drug regimen including a protease inhibitor in a patient with human immunodeficiency virus infection to the editor. (19078336)
1998
30
Treatment of frozen shoulder by distension and manipulation under local anaesthesia. (8872541)
1996
31
Chiropractic treatment of frozen shoulder syndrome (adhesive capsulitis) utilizing mechanical force, manually assisted short lever adjusting procedures. (7790781)
1995
32
The resistant frozen shoulder. Manipulation versus arthroscopic release. (7554636)
1995
33
Frozen shoulder. (7834017)
1994
34
Thermography of frozen shoulder and rotator cuff tendinitis. (1458786)
1992
35
Isolated ACTH deficiency presenting with bilateral frozen shoulder. (1646665)
1991
36
Radiological erosions in frozen shoulder. (2379045)
1990
37
Frozen shoulder. Part II: Treatment by manipulation under anesthesia. (2771824)
1989
38
Frozen shoulder. (20894543)
1984
39
Frozen shoulder. (20894460)
1983
40
Frozen shoulder (adhesive capsulitis) (7120251)
1982
41
The natural history of "idiopathic" frozen shoulder. (670287)
1978
42
DMSO an adjutant to physical therapy in the chronic frozen shoulder. (4167319)
1967
43
Frozen shoulder. (14040201)
1961
44
The frozen shoulder. (13100167)
1953
45
Frozen shoulder (scapulobicipital syndrome). (13081966)
1953
46
Loss of scapulohumeral motion (frozen shoulder). (14903846)
1952
47
FROZEN shoulder. (14910026)
1952
48
The frozen shoulder; treatment by manipulation. (14812093)
1951
49
The frozen shoulder. (18153629)
1949
50
Physical treatment of the frozen shoulder. (18860778)
1948

Genetic Variations for Frozen Shoulder

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Expression for genes affiliated with Frozen Shoulder

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Frozen Shoulder

Search GEO for disease gene expression data for Frozen Shoulder.

Pathways for genes affiliated with Frozen Shoulder

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53Reactome, 37NCBI BioSystems Database, 55SinoBiological, 52R&D Systems, 12EMD Millipore, 29KEGG, 49PharmGKB, 51QIAGEN
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Pathways related to Frozen Shoulder according to GeneCards/GeneDecks:

(show all 41)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8S100B, MAPK1
29.7MAPK1, VEGFA
39.7CD40, MAPK8
49.6MAPK1, MAPK8
59.3COL1A1, ITGB1
69.3CD40, MAPK1, MAPK8
7
Hide members
9.3MAPK8, MAPK1, CD40
89.3MAPK1, ITGB1
9
G-protein signaling Ras family GTPases in kinase cascades (scheme)
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9.3MAPK8, MAPK1, MMP3
109.3MAPK8, MAPK1, MMP3
11
Hide members
9.2VEGFA, MAPK8, MAPK1
12
Hide members
9.2MAPK1, MAPK8, VEGFA
13
Hide members
9.2MAPK1, MAPK8, VEGFA
14
Cell adhesion ECM remodeling
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9.0COL1A1, ITGB1, MMP3
159.0MAPK1, ITGB1, COL1A1
168.9CD40, ITGB1, HLA-B
17
Hide members
8.8MAPK1, MAPK8, ITGB1
188.8ITGB1, MAPK8, MAPK1
19
Development PDGF signaling via STATs and NF-kB
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8.8ITGB1, MAPK8, MAPK1
208.8MAPK1, MAPK8, ITGB1
218.8ITGB1, MAPK8, MAPK1
228.8ITGB1, MAPK8, MAPK1
23
Hide members
8.8MAPK1, MAPK8, ITGB1
248.8ITGB1, MAPK8, MAPK1
25
Hide members
8.7MAPK1, MAPK8, VEGFA, HLA-B
26
Hide members
8.7MAPK1, ITGB1, LHB, COL1A1
278.5MAPK1, VEGFA, ITGB1, COL1A1
28
Hide members
8.5COL1A1, ITGB1, VEGFA, MAPK1
29
Development Prolactin receptor signaling
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8.5LHB, ITGB1, MAPK8, MAPK1
30
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8.5CD40, MAPK1, MAPK8, ITGB1
31
Hide members
8.4MAPK1, MAPK8, ITGB1, COL1A1
328.3ITGB1, VEGFA, MAPK8, MAPK1
33
Translation Insulin regulation of translation
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8.3ITGB1, VEGFA, MAPK8, MAPK1
34
Hide members
8.3ITGB1, VEGFA, MAPK8, MAPK1
35
Hide members
8.3MAPK1, MAPK8, VEGFA, ITGB1
36
Hide members
8.2MMP3, MAPK1, MAPK8, ITGB1, LHB
37
Hide members
8.0COL1A1, ITGB1, VEGFA, MAPK8, MAPK1
38
Hide members
7.9COL1A1, LHB, ITGB1, MAPK8, MAPK1, MMP3
39
Development Endothelin-1/EDNRA signaling
Hide members
7.8MAPK1, MAPK8, VEGFA, ITGB1, LHB, COL1A1
40
Hide members
7.7S100B, HLA-B, ITGB1, MAPK8, MAPK1, CD40
41
Hide members
7.2COL1A1, LHB, S100B, ITGB1, VEGFA, MAPK8

Compounds for genes affiliated with Frozen Shoulder

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Sources:
44Novoseek, 2BitterDB, 11DrugBank, 59Tocris Bioscience, 49PharmGKB, 28IUPHAR, 24HMDB
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Compounds related to Frozen Shoulder according to GeneCards/GeneDecks:

(show top 50)    (show all 76)
idCompoundScoreTop Affiliating Genes
1butyrate4410.4CD40
2ilomastat4410.4MMP3
3pge24410.2COL1A1, VEGFA
41,4-diamino-2,3-dicyano-1,4-bis(2-aminophenylthio)butadiene449.9MAPK8, MAPK1
53-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide449.9CD40, S100B, MAPK1
6magnolol449.8MAPK8, MAPK1
7ecori449.8COL1A1, S100B, HLA-B
8nobiletin449.7MAPK8, MAPK1
9hcec449.7MMP3, MAPK1, MAPK8
104-amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine449.6MAPK1, MAPK8
11chloramphenicol44 2 1111.6S100B, CD40, MMP3, COL1A1
12pd 169316449.6VEGFA, MAPK8, MAPK1
13ag-126449.6MAPK8, MAPK1
14ro 31 8220449.6MAPK8, MAPK1, VEGFA
15pd153035449.6VEGFA, MAPK1, MAPK8
16apocynin44 5910.5VEGFA, MAPK8, MAPK1
17simvastatin44 49 59 28 11 2414.5CD40, MMP3, VEGFA, COL1A1
18ns 39844 5910.5MAPK1, MAPK8, VEGFA
19ang ii449.5MAPK1, MAPK8, VEGFA
20diphenyleneiodonium449.5MAPK1, VEGFA, MAPK8
2115-deoxy-delta-12,14-prostaglandin j2449.4MAPK1, MAPK8, VEGFA
22ribonucleic acid449.4HLA-B, CD40, COL1A1, MMP3
23paclitaxel44 49 1111.3MAPK1, VEGFA, MAPK8, S100B
24celecoxib44 59 28 49 11 2414.3VEGFA, MAPK8, MAPK1, MMP3
25curcumin449.2MMP3, MAPK1, MAPK8, VEGFA
26herbimycin a44 5910.2MAPK8, CD40, ITGB1
27rapamycin449.1MAPK1, VEGFA, MAPK8, CD40
28triptolide449.0MAPK8, MAPK1, CD40, MMP3, VEGFA
29imatinib44 49 1111.0MAPK1, VEGFA, S100B, COL1A1, MAPK8
30oxygen44 2410.0MAPK8, S100B, CD40, ITGB1
31n acetylcysteine449.0VEGFA, MAPK8, MAPK1, CD40, MMP3
32ly294002449.0VEGFA, MAPK8, MAPK1, CD40
33sp 60012544 599.9MAPK8, CD40, MAPK1, ITGB1
34matrigel448.9ITGB1, MAPK1, VEGFA, MMP3
35zinc44 249.7S100B, HLA-B, CD40, MMP3, COL1A1
36thymidine44 249.7S100B, MAPK1, CD40, COL1A1, ITGB1
37cyclosporin a44 28 5910.7CD40, HLA-B, MMP3, S100B, ITGB1
3812-o-tetradecanoylphorbol 13-acetate448.6MAPK1, ITGB1, MAPK8, MMP3, CD40
39actinomycin d448.6CD40, MAPK1, MAPK8, VEGFA
40wortmannin448.6CD40, MAPK8, S100B, ITGB1, MAPK1
41pd 98,059448.6MMP3, MAPK1, MAPK8, ITGB1, CD40
42serine448.5S100B, HLA-B, ITGB1, MAPK8, MMP3
43paraffin448.4VEGFA, S100B, HLA-B, MMP3, CD40, ITGB1
44nitric oxide44 11 2410.3ITGB1, S100B, HLA-B, MAPK1, CD40
45dexamethasone44 49 28 1111.2MAPK1, COL1A1, S100B, ITGB1, VEGFA, MAPK8
46sb 20358044 599.2MAPK1, VEGFA, ITGB1, MAPK8, MMP3, CD40
47genistein44 28 59 2 11 2413.2MMP3, MAPK1, MAPK8, VEGFA, ITGB1, CD40
48vegf447.6ITGB1, MMP3, CD40, MAPK1, MAPK8, VEGFA
49retinoic acid44 248.6CD40, MAPK1, MAPK8, ITGB1, HLA-B, S100B
50tyrosine447.4S100B, CD40, MMP3, MAPK1, VEGFA, ITGB1

GO Terms for genes affiliated with Frozen Shoulder

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16Gene Ontology
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Cellular components related to Frozen Shoulder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.6MMP3, CD40, VEGFA, S100B, LHB, COL1A1

Biological processes related to Frozen Shoulder according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of protein kinase C signaling cascadeGO:0900379.9VEGFA, CD40
2platelet activationGO:0301689.2CD40, MAPK1, VEGFA, COL1A1
3cell migration involved in sprouting angiogenesisGO:0020429.1VEGFA, ITGB1
4regulation of immune responseGO:0507768.9CD40, ITGB1, HLA-B
5cellular response to mechanical stimulusGO:0712608.7CD40, MAPK8, ITGB1, COL1A1
6positive regulation of cell migrationGO:0303358.7COL1A1, ITGB1, VEGFA, MAPK1
7blood coagulationGO:0075968.5MAPK1, VEGFA, ITGB1, COL1A1
8positive regulation of cell proliferationGO:0082848.3S100B, ITGB1, VEGFA, MAPK1

Molecular functions related to Frozen Shoulder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1fibronectin bindingGO:0019689.2VEGFA, ITGB1

Products for genes affiliated with Frozen Shoulder

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  • Antibodies
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Sources for Frozen Shoulder

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet