MCID: FRZ001
MIFTS: 49

Frozen Shoulder malady

Summaries for Frozen Shoulder

About this section
Sources:
63Wikipedia, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Wikipedia:63 Frozen shoulder, medically referred to as adhesive capsulitis, is a disorder in which the shoulder... more...

MalaCards: Frozen Shoulder, also known as adhesive capsulitis of shoulder, is related to diabetes mellitus and osteoarthritis. An important gene associated with Frozen Shoulder is LHB (luteinizing hormone beta polypeptide), and among its related pathways are Advanced glycosylation endproduct receptor signaling and Angiogenesis. The compounds butyrate and ilomastat have been mentioned in the context of this disorder. Affiliated tissues include bone, testes and skin, and related mouse phenotypes are tumorigenesis and nervous system.

Aliases & Classifications for Frozen Shoulder

About this section
Sources:
8Disease Ontology, 10DISEASES, 60UMLS, 56SNOMED-CT, 34MeSH, 27ICD9CM, 25ICD10
See all sources

Classifications:



Aliases & Descriptions:

frozen shoulder 8 10 60
adhesive capsulitis of shoulder 8
adhesions-capsulitis,shoulder 8


External Ids:

Disease Ontology8 DOID:14188
MeSH34 D002062
ICD9CM27 726.0
ICD1025 M75.0

Related Diseases for Frozen Shoulder

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Frozen Shoulder via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 99)
idRelated DiseaseScoreTop Affiliating Genes
1diabetes mellitus30.5HLA-B, VEGFA, MAPK8, MMP3
2osteoarthritis30.0COL1A1, ITGB1, MAPK8, MAPK1, MMP3, ACRV1
3tendinitis10.5
4calcific tendinitis10.5
5parkinson's disease10.2
6tuberculosis10.2
7pulmonary tuberculosis10.1
8neuronitis10.1
9cervicitis10.1
10gallbladder cancer10.1
11hyperthyroidism10.1
12type 2 diabetes mellitus10.1
13familial dupuytren contracture10.1
14multiple myeloma10.0CD40
15cervical cancer10.0CD40
16kawasaki disease10.0MMP3
17dementia10.0MMP3
18acute myocardial infarction10.0CD40
19hordeolum10.0ACRV1
20hemangiopericytoma10.0S100B
21connective tissue disease10.0CD40
22macroglobulinemia, waldenstrom, somatic10.0CD40
23dermatofibrosarcoma10.0COL1A1
24sjogren's syndrome10.0CD40
25hepatitis c10.0ITGB1
26cholesteatoma10.0MMP3
27uveitis10.0HLA-B
28thyroid cancer10.0MAPK1
29rhabdomyosarcoma10.0S100B
30bladder carcinoma10.0HLA-B
31vaccinia10.0HLA-B
32meningitis10.0HLA-B
33adenoma10.0HLA-B
34infertility10.0ITGB1
35hepatitis10.0HLA-B
36nephritis10.0ITGB1
37leiomyoma10.0MMP3, S100B
38glomerulonephritis10.0ITGB1
39dermatofibrosarcoma protuberans10.0COL1A1, S100B
40encephalitis10.0HLA-B
41influenza10.0HLA-B
42synovitis10.0MMP3, ITGB1
43letterer-siwe disease10.0CD40, S100B
44hepatitis b10.0MMP3, HLA-B
45multiple sclerosis10.0CD40, HLA-B
46pneumonia10.0CD40, MAPK8
47pulmonary fibrosis10.0MAPK8, COL1A1
48cystic fibrosis10.0CD40, MAPK8
49vasculitis10.0ITGB1, HLA-B
50keratitis10.0VEGFA

Graphical network of the top 20 diseases related to Frozen Shoulder:



Diseases related to frozen shoulder

Clinical Features for Frozen Shoulder

About this section

Drugs & Therapeutics for Frozen Shoulder

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Frozen Shoulder

Drug clinical trials:

Search ClinicalTrials for Frozen Shoulder

Search NIH Clinical Center for Frozen Shoulder

Search CenterWatch for Frozen Shoulder

Genetic Tests for Frozen Shoulder

About this section

Anatomical Context for Frozen Shoulder

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Frozen Shoulder:

32
Bone, Testes, Skin, Endothelial

Animal Models for Frozen Shoulder or affiliated genes

About this section
Sources:
36MGI
See all sources

Publications for Frozen Shoulder

About this section
Sources:
50PubMed
See all sources

Articles related to Frozen Shoulder:

(show top 50)    (show all 324)
idTitleAuthorsYear
1
Comparative study of the clinical efficacy of the selective cyclooxygenase-2 inhibitor celecoxib compared with loxoprofen in patients with frozen shoulder. (23400718)
2013
2
Matrix metalloproteinase, tissue inhibitor of metalloproteinase and transforming growth factor-beta 1 in frozen shoulder, and their changes as response to intensive stretching and supervised neglect exercise. (23604641)
2013
3
Frozen shoulder : long-term outcome following arthrographic distension. (24205764)
2013
4
Management of frozen shoulder: a systematic review and cost-effectiveness analysis. (22405512)
2012
5
Miniopen coracohumeral ligament release and manipulation for idiopathic frozen shoulder. (23204764)
2012
6
Frozen shoulder. (22219239)
2012
7
MRI findings for frozen shoulder evaluation: is the thickness of the coracohumeral ligament a valuable diagnostic tool? (22163326)
2011
8
Is the extended release of the inferior glenohumeral ligament necessary for frozen shoulder? (20362834)
2010
9
The results of arthroscopic capsular release in the treatment of frozen shoulder - two-year follow-up. (20675863)
2010
10
Posterior arthroscopic capsular release in frozen shoulder. (19111214)
2009
11
The classic. Loss of scapulohumeral motion (frozen shoulder). Ann Surg. 1952;135:193-204. (18264843)
2008
12
The influence of arthroscopic subscapularis tendon and capsule release on internal rotation strength in treatment of frozen shoulder. (18272795)
2008
13
Comparison between intraarticular triamcinolone acetonide and methylprednisolone acetate injections in treatment of frozen shoulder. (17457436)
2007
14
The frozen shoulder syndrome. Description of a new technique and five case reports using the subscapular nerve block and subscapularis trigger point infiltration. (16916183)
2006
15
Frozen shoulder as the initial presentation of gallbladder cancer diagnosed by fine needle aspiration cytology. (15966303)
2005
16
Shoulder girdle neoplasms mimicking frozen shoulder syndrome. (14564266)
2003
17
Operative management of the frozen shoulder in patients with diabetes. (12469088)
2002
18
Manipulation under anaesthesia for frozen shoulder. (12378350)
2002
19
The patient with frozen shoulder. (12452117)
2002
20
Acupuncture for frozen shoulder. (11773673)
2001
21
Manipulation under anesthesia for frozen shoulder with and without steroid injection. (11552189)
2001
22
Manipulation under anesthesia for primary frozen shoulder: effect on early recovery and return to activity. (10717858)
2000
23
Need patients be stuck with frozen shoulder? (11138600)
2000
24
An arthroscopic technique for treating patients with frozen shoulder. (10024027)
1999
25
Frozen shoulder: a new delayed complication of protease inhibitor therapy? . (9523391)
1998
26
Frozen Shoulder: Diagnosis and Management. (10797215)
1997
27
Can flunarizine induce frozen shoulder? (8817758)
1996
28
Frozen shoulder. A long-term follow-up. (1624489)
1992
29
The frozen shoulder: diagnosis and treatment. Prospective study of 50 cases of adhesive capsulitis. (1281062)
1992
30
Abnormal temperature control suggesting sympathetic dysfunction in the shoulder skin of patients with frozen shoulder. (1643452)
1992
31
Frozen shoulder: current concepts. (2218428)
1990
32
Frozen shoulder and other shoulder disturbances in Parkinson's disease. (2709037)
1989
33
Frozen shoulder in hyperthyroidism. (3498494)
1987
34
Frozen shoulder. (3786418)
1986
35
Frozen shoulder. (20894518)
1984
36
Frozen shoulder. (20894558)
1984
37
Manipulation as the primary treatment of the frozen shoulder. (7143295)
1982
38
Arthroscopic findings in the frozen shoulder. (7218244)
1981
39
Immunoglobulin-A, HLA-B27, and frozen shoulder. (6116899)
1981
40
Frozen shoulder. (6115273)
1981
41
Frozen shoulder. (7393496)
1980
42
The frozen shoulder. Clinical and radiographical observations. The effect of manipulation under general anesthesia. Structure and glycosaminoglycan content of the joint capsule. Local bone metabolism. (4952729)
1969
43
Frozen shoulder. (13945870)
1963
44
The components of the frozen shoulder. (13838127)
1960
45
Frozen shoulder: methods for bringing about early mobilization. (13585158)
1958
46
Checkrein shoulder; a type of frozen shoulder; diagnosis and treatment by manipulation and ACTH or cortisone. (13119871)
1954
47
Treatment of the frozen Shoulder. (13180891)
1954
48
The frozen shoulder. (13177296)
1954
49
Exercise treatment for the frozen shoulder. (15424027)
1950
50
The painful stiff shoulder (frozen shoulder). (21018841)
1946

Genetic Variations for Frozen Shoulder

About this section

Expression for genes affiliated with Frozen Shoulder

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Frozen Shoulder

Search GEO for disease gene expression data for Frozen Shoulder.

Pathways for genes affiliated with Frozen Shoulder

About this section
Sources:
53Reactome, 37NCBI BioSystems Database, 55SinoBiological, 52R&D Systems, 12EMD Millipore, 29KEGG, 49PharmGKB, 51QIAGEN
See all sources

Pathways related to Frozen Shoulder according to GeneCards/GeneDecks:

(show all 41)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8S100B, MAPK1
29.7MAPK1, VEGFA
39.7CD40, MAPK8
49.6MAPK1, MAPK8
59.3COL1A1, ITGB1
69.3CD40, MAPK1, MAPK8
7
Hide members
9.3MAPK8, MAPK1, CD40
89.3MAPK1, ITGB1
9
G-protein signaling Ras family GTPases in kinase cascades (scheme)
Hide members
9.3MAPK8, MAPK1, MMP3
109.3MAPK8, MAPK1, MMP3
11
Hide members
9.2VEGFA, MAPK8, MAPK1
12
Hide members
9.2MAPK1, MAPK8, VEGFA
13
Hide members
9.2MAPK1, MAPK8, VEGFA
14
Cell adhesion ECM remodeling
Hide members
9.0COL1A1, ITGB1, MMP3
159.0MAPK1, ITGB1, COL1A1
168.9CD40, ITGB1, HLA-B
17
Hide members
8.8MAPK1, MAPK8, ITGB1
188.8ITGB1, MAPK8, MAPK1
19
Development PDGF signaling via STATs and NF-kB
Hide members
8.8ITGB1, MAPK8, MAPK1
208.8MAPK1, MAPK8, ITGB1
218.8ITGB1, MAPK8, MAPK1
228.8ITGB1, MAPK8, MAPK1
23
Hide members
8.8MAPK1, MAPK8, ITGB1
248.8ITGB1, MAPK8, MAPK1
25
Hide members
8.7MAPK1, MAPK8, VEGFA, HLA-B
26
Hide members
8.7MAPK1, ITGB1, LHB, COL1A1
278.5MAPK1, VEGFA, ITGB1, COL1A1
28
Hide members
8.5COL1A1, ITGB1, VEGFA, MAPK1
29
Development Prolactin receptor signaling
Hide members
8.5LHB, ITGB1, MAPK8, MAPK1
30
Hide members
8.5CD40, MAPK1, MAPK8, ITGB1
31
Hide members
8.4MAPK1, MAPK8, ITGB1, COL1A1
328.3ITGB1, VEGFA, MAPK8, MAPK1
33
Translation Insulin regulation of translation
Hide members
8.3ITGB1, VEGFA, MAPK8, MAPK1
34
Hide members
8.3ITGB1, VEGFA, MAPK8, MAPK1
35
Hide members
8.3MAPK1, MAPK8, VEGFA, ITGB1
36
Hide members
8.2MMP3, MAPK1, MAPK8, ITGB1, LHB
37
Hide members
8.0COL1A1, ITGB1, VEGFA, MAPK8, MAPK1
38
Hide members
7.9COL1A1, LHB, ITGB1, MAPK8, MAPK1, MMP3
39
Development Endothelin-1/EDNRA signaling
Hide members
7.8MAPK1, MAPK8, VEGFA, ITGB1, LHB, COL1A1
40
Hide members
7.7S100B, HLA-B, ITGB1, MAPK8, MAPK1, CD40
41
Hide members
7.2COL1A1, LHB, S100B, ITGB1, VEGFA, MAPK8

Compounds for genes affiliated with Frozen Shoulder

About this section
Sources:
44Novoseek, 2BitterDB, 11DrugBank, 59Tocris Bioscience, 49PharmGKB, 28IUPHAR, 24HMDB
See all sources

Compounds related to Frozen Shoulder according to GeneCards/GeneDecks:

(show top 50)    (show all 76)
idCompoundScoreTop Affiliating Genes
1butyrate4410.4CD40
2ilomastat4410.4MMP3
3pge24410.2COL1A1, VEGFA
41,4-diamino-2,3-dicyano-1,4-bis(2-aminophenylthio)butadiene449.9MAPK8, MAPK1
53-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide449.9CD40, S100B, MAPK1
6magnolol449.8MAPK8, MAPK1
7ecori449.8COL1A1, S100B, HLA-B
8nobiletin449.7MAPK8, MAPK1
9hcec449.7MMP3, MAPK1, MAPK8
104-amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine449.6MAPK1, MAPK8
11chloramphenicol44 2 1111.6S100B, CD40, MMP3, COL1A1
12pd 169316449.6VEGFA, MAPK8, MAPK1
13ag-126449.6MAPK8, MAPK1
14ro 31 8220449.6MAPK8, MAPK1, VEGFA
15pd153035449.6VEGFA, MAPK1, MAPK8
16apocynin44 5910.5VEGFA, MAPK8, MAPK1
17simvastatin44 49 59 28 11 2414.5CD40, MMP3, VEGFA, COL1A1
18ns 39844 5910.5MAPK1, MAPK8, VEGFA
19ang ii449.5MAPK1, MAPK8, VEGFA
20diphenyleneiodonium449.5MAPK1, VEGFA, MAPK8
2115-deoxy-delta-12,14-prostaglandin j2449.4MAPK1, MAPK8, VEGFA
22ribonucleic acid449.4HLA-B, CD40, COL1A1, MMP3
23paclitaxel44 49 1111.3MAPK1, VEGFA, MAPK8, S100B
24celecoxib44 59 28 49 11 2414.3VEGFA, MAPK8, MAPK1, MMP3
25curcumin449.2MMP3, MAPK1, MAPK8, VEGFA
26herbimycin a44 5910.2MAPK8, CD40, ITGB1
27rapamycin449.1MAPK1, VEGFA, MAPK8, CD40
28triptolide449.0MAPK8, MAPK1, CD40, MMP3, VEGFA
29imatinib44 49 1111.0MAPK1, VEGFA, S100B, COL1A1, MAPK8
30oxygen44 2410.0MAPK8, S100B, CD40, ITGB1
31n acetylcysteine449.0VEGFA, MAPK8, MAPK1, CD40, MMP3
32ly294002449.0VEGFA, MAPK8, MAPK1, CD40
33sp 60012544 599.9MAPK8, CD40, MAPK1, ITGB1
34matrigel448.9ITGB1, MAPK1, VEGFA, MMP3
35zinc44 249.7S100B, HLA-B, CD40, MMP3, COL1A1
36thymidine44 249.7S100B, MAPK1, CD40, COL1A1, ITGB1
37cyclosporin a44 28 5910.7CD40, HLA-B, MMP3, S100B, ITGB1
3812-o-tetradecanoylphorbol 13-acetate448.6MAPK1, ITGB1, MAPK8, MMP3, CD40
39actinomycin d448.6CD40, MAPK1, MAPK8, VEGFA
40wortmannin448.6CD40, MAPK8, S100B, ITGB1, MAPK1
41pd 98,059448.6MMP3, MAPK1, MAPK8, ITGB1, CD40
42serine448.5S100B, HLA-B, ITGB1, MAPK8, MMP3
43paraffin448.4VEGFA, S100B, HLA-B, MMP3, CD40, ITGB1
44nitric oxide44 11 2410.3ITGB1, S100B, HLA-B, MAPK1, CD40
45dexamethasone44 49 28 1111.2MAPK1, COL1A1, S100B, ITGB1, VEGFA, MAPK8
46sb 20358044 599.2MAPK1, VEGFA, ITGB1, MAPK8, MMP3, CD40
47genistein44 28 59 2 11 2413.2MMP3, MAPK1, MAPK8, VEGFA, ITGB1, CD40
48vegf447.6ITGB1, MMP3, CD40, MAPK1, MAPK8, VEGFA
49retinoic acid44 248.6CD40, MAPK1, MAPK8, ITGB1, HLA-B, S100B
50tyrosine447.4S100B, CD40, MMP3, MAPK1, VEGFA, ITGB1

GO Terms for genes affiliated with Frozen Shoulder

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Frozen Shoulder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.6MMP3, CD40, VEGFA, S100B, LHB, COL1A1

Biological processes related to Frozen Shoulder according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of protein kinase C signaling cascadeGO:0900379.9VEGFA, CD40
2platelet activationGO:0301689.2CD40, MAPK1, VEGFA, COL1A1
3cell migration involved in sprouting angiogenesisGO:0020429.1VEGFA, ITGB1
4regulation of immune responseGO:0507768.9CD40, ITGB1, HLA-B
5cellular response to mechanical stimulusGO:0712608.7CD40, MAPK8, ITGB1, COL1A1
6positive regulation of cell migrationGO:0303358.7COL1A1, ITGB1, VEGFA, MAPK1
7blood coagulationGO:0075968.5MAPK1, VEGFA, ITGB1, COL1A1
8positive regulation of cell proliferationGO:0082848.3S100B, ITGB1, VEGFA, MAPK1

Molecular functions related to Frozen Shoulder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1fibronectin bindingGO:0019689.2VEGFA, ITGB1

Products for genes affiliated with Frozen Shoulder

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Frozen Shoulder

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet