Aliases & Classifications for Frozen Shoulder

Aliases & Descriptions for Frozen Shoulder:

Name: Frozen Shoulder 12 14 69
Bursitis 42 69
Adhesive Capsulitis of Shoulder 12
Adhesions-Capsulitis,shoulder 12

Classifications:



External Ids:

Disease Ontology 12 DOID:14188
ICD10 33 M75.0
ICD9CM 35 726.0
MeSH 42 D002062
UMLS 69 C0311223

Summaries for Frozen Shoulder

MalaCards based summary : Frozen Shoulder, also known as bursitis, is related to bursitis and olecranon bursitis, and has symptoms including arthralgia, back pain and metatarsalgia. An important gene associated with Frozen Shoulder is ASIC3 (Acid Sensing Ion Channel Subunit 3), and among its related pathways/superpathways are Ion channel transport and Development Endothelin-1/EDNRA signaling. The drugs Lidocaine and Ropivacaine have been mentioned in the context of this disorder. Affiliated tissues include bone, testes and heart, and related phenotypes are behavior/neurological and nervous system

Wikipedia : 71 Adhesive capsulitis (also known as frozen shoulder) is a painful and disabling disorder of unclear cause... more...

Related Diseases for Frozen Shoulder

Graphical network of the top 20 diseases related to Frozen Shoulder:



Diseases related to Frozen Shoulder

Symptoms & Phenotypes for Frozen Shoulder

UMLS symptoms related to Frozen Shoulder:


arthralgia, back pain, metatarsalgia, muscle cramp, sciatica, myalgia, bursal pain, bursal tenderness

MGI Mouse Phenotypes related to Frozen Shoulder:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.85 ASIC1 ASIC2 ASIC3 COL1A1 CTNNB1 IGF2
2 nervous system MP:0003631 9.63 ASIC1 ASIC2 ASIC3 COL1A1 CTNNB1 IGF2
3 hearing/vestibular/ear MP:0005377 9.62 ASIC2 ASIC3 COL1A1 CTNNB1
4 muscle MP:0005369 9.56 CTNNB1 IGF2 ASIC2 COL1A1
5 no phenotypic analysis MP:0003012 9.26 ASIC2 COL1A1 CTNNB1 IGF2
6 vision/eye MP:0005391 9.02 ASIC2 ASIC3 COL1A1 CTNNB1 IGF2

Drugs & Therapeutics for Frozen Shoulder

Drugs for Frozen Shoulder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 46)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lidocaine Approved, Vet_approved Phase 4,Phase 3 137-58-6 3676
2
Ropivacaine Approved Phase 4 84057-95-4 71273 175805
3
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
4
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
5
Nitrous oxide Approved, Vet_approved Phase 4 10024-97-2 948
6 Anesthetics Phase 4,Phase 3
7 Central Nervous System Depressants Phase 4,Phase 3
8 Peripheral Nervous System Agents Phase 4,Phase 3
9 Anesthetics, Local Phase 4,Phase 3
10 Anti-Arrhythmia Agents Phase 4,Phase 3
11 Diuretics, Potassium Sparing Phase 4,Phase 3
12 Sodium Channel Blockers Phase 4,Phase 3
13 Antiemetics Phase 4
14 Anti-Inflammatory Agents Phase 4,Phase 3
15 Antineoplastic Agents, Hormonal Phase 4
16 Autonomic Agents Phase 4
17 Gastrointestinal Agents Phase 4
18 glucocorticoids Phase 4,Phase 3
19 Hormone Antagonists Phase 4,Phase 3
20 Hormones Phase 4,Phase 3
21 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3
22 Methylprednisolone acetate Phase 4
23 Methylprednisolone Hemisuccinate Phase 4
24 Neuroprotective Agents Phase 4
25 Pharmaceutical Solutions Phase 4,Phase 3
26 Prednisolone acetate Phase 4
27 Prednisolone hemisuccinate Phase 4
28 Prednisolone phosphate Phase 4
29 Protective Agents Phase 4
30 Analgesics Phase 4
31 Analgesics, Non-Narcotic Phase 4
32 Anesthetics, General Phase 4
33 Anesthetics, Inhalation Phase 4
34
Triamcinolone Approved, Vet_approved Phase 3 124-94-7 31307
35 Immunosuppressive Agents Phase 3
36 triamcinolone acetonide Phase 3
37 Triamcinolone diacetate Phase 3
38 Triamcinolone hexacetonide Phase 3
39
Prilocaine Approved 721-50-6 4906
40
Menthol Approved 2216-51-5 16666
41
Vitamin A Approved, Nutraceutical, Vet_approved 11103-57-4, 68-26-8 445354
42 Retinol palmitate
43 retinol Nutraceutical
44 Eleuthero Nutraceutical
45 Goji Nutraceutical
46 Lycium Nutraceutical

Interventional clinical trials:

(show all 42)
id Name Status NCT ID Phase
1 Effectiveness of an Oxygen-nitrous Oxide Mixture During Physical Therapy for Frozen Shoulder Completed NCT01087229 Phase 4
2 Arthroscopy and Manipulation vs a Home Therapy Program in the Treatment of Adhesive Capsulitis Completed NCT00160784 Phase 4
3 An RCT in Treatment of Adhesive Capsulitis Arthrographic Joint Distention With Local Anesthetic Alone Completed NCT02001740 Phase 4
4 The Effect of 3 Ropivacaine Suprascapular Nerve Blocks in Subacute Adhesive Capsulitis: a Randomized Controlled Trial Recruiting NCT02944526 Phase 4
5 Adhesive Capsulitis: Prospective Analysis of Efficacy and Financial Impact for Use of Physical Therapy in Treatment Recruiting NCT02283996 Phase 4
6 Efficacy and Tolerance of Ultrasound-guided Needling and Lavage of Calcific Tendinitis of the Rotator Cuff Performed With or Without Subacromial Corticosteroid Injection Recruiting NCT02403856 Phase 4
7 Shoulder Adhesive Capsulitis and Ambulatory Continuous Interscalene Nerve Blocks Terminated NCT00875862 Phase 4
8 Treatment Study of Frozen Shoulder: Corticosteroid Injection in Joint Versus Wait and See Policy Unknown status NCT01570985 Phase 3
9 Scientifically Merged Acupuncture and Robot-assisted Technology (SMART) for Rehabilitation of Frozen Shoulder Syndrome: Second-year Project-Comparison of Robot and Conventional Physiotherapy (Including Preliminary Test on Healthy Volunteers) Unknown status NCT02206542 Phase 2
10 Prediction Frozen Shoulder Validation Completed NCT01157221 Phase 1, Phase 2
11 Bee Venom Acupuncture for the Treatment of Frozen Shoulder Completed NCT01526031 Phase 2
12 Clinical Study for the Treatment of Adhesive Capsulitis of the Shoulder Completed NCT02006719 Phase 2
13 AA4500 for the Treatment of Adhesive Capsulitis of the Shoulder Completed NCT01483963 Phase 2
14 Collagenase in the Treatment of Adhesive Capsulitis (Frozen Shoulder) Withdrawn NCT00261196 Phase 2
15 Quantum Spectrum Radiation Emitter for Adhesive Capsulitis Unknown status NCT02133833 Phase 1
16 The Study of Different Treatment Programs for Patients With Frozen Shoulder Unknown status NCT01249040
17 Mobilization Techniques in Patients With Frozen Shoulder: a Randomized Multiple-Treatment Trial Unknown status NCT00172601
18 Surgery or Capsular Distention With Steroid in the Treatment of Primary Frozen Shoulder? Unknown status NCT01029600
19 Acupuncture for Treatment of Frozen Shoulder Syndrome Unknown status NCT02076308
20 Corticosteroids and / or Arthrographic Distention in the Treatment of Adhesive Capsulitis Unknown status NCT01983527
21 Indwelling Interscalene Nerve Catheters in Surgical Management of Idiopathic Adhesive Capsulitis Unknown status NCT01606332
22 Natural Course of Adhesive Capsulitis of Hip Unknown status NCT01449227
23 Prevalence of Unknown and Known Diabetes in Patients With Frozen Shoulder Completed NCT01978886
24 Clinical Trial on Frozen Shoulder Using Bilateral Shoulder Radiography in Different Position Completed NCT02169206
25 Effect of Combined Intra-articular Injection of Lidocaine Plus Physiotherapy in Treatment of Frozen Shoulder Completed NCT01817348
26 Prevalence of Impaired Glucose Tolerance (IGT) in Patients With Frozen Shoulder Completed NCT00926094
27 Rotator Interval and Intra-articular Corticosteroid Injection for Frozen Shoulder Completed NCT00840229
28 Ultrasound-Guided Glenohumeral Steroid Injection Completed NCT02461368
29 Correlating Clinical Disease State With Color Doppler Ultrasound Completed NCT00761943
30 Domiciliary Physiotherapy in Women Undergoing Treatment for Breast Cancer Radiation Completed NCT01940107
31 Translational Manipulation Under Interscalene Block for Adhesive Capsulitis of the Shoulder (TMACS) Completed NCT03090555
32 Validation of a Kinematic Functional Shoulder Score Including Only Essential Movements Completed NCT01431417
33 Massage in Treating Painful Shoulder Completed NCT01307826
34 Noxipoint Therapy Versus Standard Physical Therapy Using Electrical Stimulation for Chronic Pain Completed NCT01578148
35 Validation of a Score for Shoulder Function Evaluation Based on Movement Analysis Completed NCT01281085
36 Trial of Resistance and Endurance Exercise in Amyotrophic Lateral Sclerosis (ALS) Completed NCT01521728
37 The Effect of Integrated CAM Treatment in Hospitalized Patients Completed NCT02257723
38 Manipulation Under Anesthesia Versus Arthroscopic Capsular Release in the Treatment of Adhesive Capsulitis Recruiting NCT01961219
39 Formal Physical Therapy (PT) vs. Home PT for Adhesive Capsulitis Active, not recruiting NCT03049787
40 Efficacy of Manual Therapy and Exercise in Patients With Shoulder Adhesive Capsulitis. A Randomized Clinical Trial. Not yet recruiting NCT02976974
41 Efficacy of Corticosteroid Injection Into Coracohumeral Ligament in Patients With Adhesive Capsulitis of the Shoulder Not yet recruiting NCT03013205
42 Adhesive Capsulitis and Dynamic Splinting Terminated NCT01874821

Search NIH Clinical Center for Frozen Shoulder

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: bursitis

Genetic Tests for Frozen Shoulder

Anatomical Context for Frozen Shoulder

MalaCards organs/tissues related to Frozen Shoulder:

39
Bone, Testes, Heart, Endothelial, Skin, Breast

Publications for Frozen Shoulder

Articles related to Frozen Shoulder:

(show top 50) (show all 402)
id Title Authors Year
1
Activity- vs. structural-oriented treatment approach for frozen shoulder: a randomized controlled trial. ( 28081633 )
2017
2
Shoulder proprioception - lessons we learned from idiopathic frozen shoulder. ( 26968796 )
2016
3
The management of secondary frozen shoulder after anterior shoulder dislocation - The results of manipulation under anaesthesia and injection. ( 27053831 )
2016
4
The clinical effect of hydraulic distension plus manual therapy on patients with frozen shoulder. ( 27630441 )
2016
5
Limited capsular release and controlled manipulation under anaesthesia for the treatment of frozen shoulder. ( 27582995 )
2016
6
Natural history of frozen shoulder: fact or fiction? A systematic review. ( 27641499 )
2016
7
Intelligent framework for diagnosis of frozen shoulder using cross sectional survey and case studies. ( 27818878 )
2016
8
The pathophysiology associated with primary (idiopathic) frozen shoulder: A systematic review. ( 27527912 )
2016
9
Factors Associated with Pain, Disability and Quality of Life in Patients Suffering from Frozen Shoulder. ( 27517070 )
2016
10
Platelet-Rich Plasma for Frozen Shoulder: A Case Report. ( 26894228 )
2016
11
Range of motion of diabetic frozen shoulder recovers to the contralateral level. ( 27856934 )
2016
12
Proper site of corticosteroid injection for the treatment of idiopathic frozen shoulder: Results from a randomized trial. ( 26875065 )
2016
13
Motor Ingredients Derived from a Wearable Sensor-Based Virtual Reality System for Frozen Shoulder Rehabilitation. ( 27642600 )
2016
14
Is There a Genetic Predisposition to Frozen Shoulder?: A Systematic Review and Meta-Analysis. ( 27490134 )
2016
15
Characteristics of dynamic magnetic resonance imaging of idiopathic severe frozen shoulder. ( 27539943 )
2016
16
INVESTIGATION OF THE EFFECTIVENESS OF ACUPUNCTURE IN THE TREATMENT OF FROZEN SHOULDER. ( 27698596 )
2016
17
Characterization of a frozen shoulder model using immobilization in rats. ( 27931231 )
2016
18
Shoulder pain in primary care: frozen shoulder. ( 27477374 )
2016
19
Intra-articular injection, subacromial injection, and hydrodilatation for primary frozen shoulder: a randomized clinical trial. ( 26927433 )
2016
20
The Treatment of Fibrosis of Joint Synovium and Frozen Shoulder by Smad4 Gene Silencing in Rats. ( 27351864 )
2016
21
What is the most effective treatment for frozen shoulder? ( 27554676 )
2016
22
Does Scapular Motion Regress with Aging and is It Restricted in Patients with Idiopathic Frozen Shoulder? ( 27733880 )
2016
23
EvaluatA+ng the effectiveness of frozen shoulder treatment on the right and left sides. ( 26957759 )
2016
24
Serial Comparison of Clinical Outcomes After Arthroscopic Capsular Release for Refractory Frozen Shoulder With and Without Diabetes. ( 27062011 )
2016
25
Prevalence of hypothyroidism in patients with frozen shoulder. ( 27424251 )
2016
26
Multiple versus single ultrasound guided suprascapular nerve block in treatment of frozen shoulder in diabetic patients. ( 27858673 )
2016
27
How to treat a frozen shoulder? A survey among shoulder specialists in the Netherlands and Belgium. ( 26984658 )
2016
28
Short-term clinical results of frozen shoulder treated with shoulder manipulation under ultrasound-guided cervical nerve root block at outpatient setting: A case series. ( 27890438 )
2016
29
Association of MMP3 genotype with susceptibility to frozen shoulder: a case-control study in a Chinese Han population. ( 27051023 )
2016
30
Clinical efficacy of hydrodistention with joint manipulation under interscalene block compared with intra-articular corticosteroid injection for frozen shoulder: a prospective randomized controlled study. ( 27771263 )
2016
31
Primary Frozen Shoulder Syndrome: Arthroscopic Capsular Release. ( 26870652 )
2015
32
Does adding mobilization to stretching improve outcomes for people with frozen shoulder? A randomized controlled clinical trial. ( 26229109 )
2015
33
Clinical Features Associated with Frozen Shoulder Syndrome in Parkinson's Disease. ( 26180653 )
2015
34
Frozen shoulder: A systematic review of therapeutic options. ( 25793166 )
2015
35
Prognostic factors and therapeutic options for treatment of frozen shoulder: a systematic review. ( 26476720 )
2015
36
Evaluation of the results of management of frozen shoulder using the arthroscopic capsular release. ( 25759152 )
2015
37
Magnetic resonance imaging and short-term clinical results of severe frozen shoulder treated with manipulation under ultrasound-guided cervical nerve root block. ( 26256012 )
2015
38
Up-regulation of acid-sensing ion channels in the capsule of the joint in frozen shoulder. ( 26033064 )
2015
39
Secondary frozen shoulder following septic arthritis - An unusual complication of magnetic resonance arthrogram. ( 25884758 )
2015
40
The effects of extracorporeal shock wave therapy on frozen shoulder patients' pain and functions. ( 26834326 )
2015
41
Frozen shoulder and corticosteroids--still a need for needles? ( 26075964 )
2015
42
Addition of lidocaine injection immediately before physiotherapy for frozen shoulder: a randomized controlled trial. ( 25714415 )
2015
43
Complete resolution of frozen shoulder syndrome in a woman treated with dextroamphetamine sulfate for chronic urinary urgency. ( 26524823 )
2015
44
Onset of Frozen Shoulder Following Pneumococcal and Influenza Vaccinations. ( 26793041 )
2015
45
Rates of surgery for frozen shoulder: an experience in England. ( 26958535 )
2015
46
Frozen shoulder after simple arthroscopic shoulder procedures: What is the risk? ( 26130353 )
2015
47
Short-term effects of high-intensity laser therapy on frozen shoulder: A prospective randomized control study. ( 25770420 )
2015
48
Integration of a Kampo Medicine, Nijutsuto, and Western Medical Treatment in the Treatment of Long-term Frozen Shoulder Refractory to Western Medical Treatment: A Case Series. ( 25613331 )
2015
49
Correlations of magnetic resonance imaging findings with clinical symptom severity and prognosis of frozen shoulder. ( 26611904 )
2015
50
Optimal time for manipulation of frozen shoulder may be between 6 and 9 months. ( 25623916 )
2015

Variations for Frozen Shoulder

Expression for Frozen Shoulder

Search GEO for disease gene expression data for Frozen Shoulder.

Pathways for Frozen Shoulder

GO Terms for Frozen Shoulder

Cellular components related to Frozen Shoulder according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 synapse GO:0045202 8.8 ASIC1 ASIC2 CTNNB1

Biological processes related to Frozen Shoulder according to GeneCards Suite gene sharing:

(show all 16)
id Name GO ID Score Top Affiliating Genes
1 ion transmembrane transport GO:0034220 9.65 ASIC1 ASIC2 ASIC3
2 skeletal system development GO:0001501 9.61 COL1A1 CTNNB1 IGF2
3 sodium ion transport GO:0006814 9.58 ASIC1 ASIC2 ASIC3
4 response to estradiol GO:0032355 9.56 COL1A1 CTNNB1
5 ossification GO:0001503 9.55 COL1A1 IGF2
6 positive regulation of MAPK cascade GO:0043410 9.54 CTNNB1 IGF2
7 sodium ion transmembrane transport GO:0035725 9.54 ASIC1 ASIC2 ASIC3
8 regulation of membrane potential GO:0042391 9.52 ASIC1 ASIC2
9 cation transmembrane transport GO:0098655 9.51 ASIC2 ASIC3
10 cation transport GO:0006812 9.5 ASIC1 ASIC2 ASIC3
11 skin development GO:0043588 9.49 COL1A1 CTNNB1
12 positive regulation of epithelial to mesenchymal transition GO:0010718 9.46 COL1A1 CTNNB1
13 response to mechanical stimulus GO:0009612 9.43 ASIC2 ASIC3 COL1A1
14 detection of mechanical stimulus involved in sensory perception GO:0050974 9.16 ASIC2 ASIC3
15 response to acidic pH GO:0010447 9.13 ASIC1 ASIC2 ASIC3
16 sensory perception of sour taste GO:0050915 8.8 ASIC1 ASIC2 ASIC3

Molecular functions related to Frozen Shoulder according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cation channel activity GO:0005261 9.43 ASIC1 ASIC2 ASIC3
2 sodium channel activity GO:0005272 9.33 ASIC1 ASIC2 ASIC3
3 ion gated channel activity GO:0022839 9.32 ASIC1 ASIC2
4 ligand-gated sodium channel activity GO:0015280 9.13 ASIC1 ASIC2 ASIC3
5 acid-sensing ion channel activity GO:0044736 8.8 ASIC1 ASIC2 ASIC3

Sources for Frozen Shoulder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....