HFI
MCID: FRC002
MIFTS: 52

Fructose Intolerance (HFI) malady

Categories: Genetic diseases, Rare diseases, Gastrointestinal diseases, Liver diseases, Nephrological diseases, Metabolic diseases

Aliases & Classifications for Fructose Intolerance

Aliases & Descriptions for Fructose Intolerance:

Name: Fructose Intolerance 54 25 13 42
Hereditary Fructose Intolerance 23 50 24 25 56 66 52
Hereditary Fructose Intolerance Syndrome 12 14 69
Fructosemia 12 24 25
Fructose-1,6-Bisphosphate Aldolase B Deficiency 12 50
Fructose-1-Phosphate Aldolase Deficiency 50 25
Fructose Intolerance, Hereditary 54 50
Aldolase B Deficiency 50 25
Aldob Deficiency 50 25
Hereditary Fructose-1-Phosphate Aldolase Deficiency 56
Fructose-1,6-Biphosphate Aldolase Deficiency 25
Fructose Aldolase B Deficiency 25
Hereditary Fructosemia 56
Fructosaemia 12
Hfi 66

Characteristics:

Orphanet epidemiological data:

56
hereditary fructose intolerance
Inheritance: Autosomal recessive; Prevalence: 1-9/100000 (Europe); Age of onset: All ages; Age of death: normal life expectancy;

HPO:

32
fructose intolerance:
Inheritance autosomal recessive inheritance


Classifications:



External Ids:

OMIM 54 229600
Disease Ontology 12 DOID:9869
ICD10 33 E74.12
ICD9CM 35 271.2
MeSH 42 D005633
NCIt 47 C84720
Orphanet 56 ORPHA469
MESH via Orphanet 43 D005633
ICD10 via Orphanet 34 E74.1
MedGen 40 C0016751
UMLS 69 C0016751

Summaries for Fructose Intolerance

NIH Rare Diseases : 50 hereditary fructose intolerance (hfi) is a metabolic disease caused by the absence of an enzyme called aldolase b. in people with hfi, ingestion of fructose (fruit sugar) and sucrose (cane or beet sugar, table sugar) causes severe hypoglycemia (low blood sugar) and the build up of dangerous substances in the liver. hfi may be relatively mild or a very severe disease. the condition is caused by mutations in the aldob gene. it is inherited in an autosomal recessive pattern. treatment involves eliminating fructose and sucrose from the diet. in the severe form, eliminating these sugars from the diet may not prevent progressive liver disease. last updated: 8/20/2015

MalaCards based summary : Fructose Intolerance, also known as hereditary fructose intolerance, is related to acquired fructose intolerance and fructose-1,6-bisphosphatase deficiency, and has symptoms including seizures, abdominal pain and nausea. An important gene associated with Fructose Intolerance is ALDOB (Aldolase, Fructose-Bisphosphate B), and among its related pathways/superpathways are Influenza A and WNT Signaling. The drugs Hydrocortisone and Pharmaceutical Solutions have been mentioned in the context of this disorder. Affiliated tissues include liver and testes, and related phenotypes are Decreased substrate adherent cell growth and homeostasis/metabolism

Genetics Home Reference : 25 Hereditary fructose intolerance is a condition that affects a person's ability to digest the sugar fructose. Fructose is a simple sugar found primarily in fruits. Affected individuals develop signs and symptoms of the disorder in infancy when fruits, juices, or other foods containing fructose are introduced into the diet. After ingesting fructose, individuals with hereditary fructose intolerance may experience nausea, bloating, abdominal pain, diarrhea, vomiting, and low blood sugar (hypoglycemia). Affected infants may fail to grow and gain weight at the expected rate (failure to thrive).

OMIM : 54 Fructose intolerance becomes apparent in infancy at the time of weaning, when fructose or sucrose is added to the diet.... (229600) more...

UniProtKB/Swiss-Prot : 66 Hereditary fructose intolerance: Autosomal recessive disease that results in an inability to metabolize fructose and related sugars. Complete exclusion of fructose results in dramatic recovery; however, if not treated properly, HFI subjects suffer episodes of hypoglycemia, general ill condition, and risk of death the remainder of life.

GeneReviews: NBK333439

Related Diseases for Fructose Intolerance

Graphical network of the top 20 diseases related to Fructose Intolerance:



Diseases related to Fructose Intolerance

Symptoms & Phenotypes for Fructose Intolerance

Symptoms by clinical synopsis from OMIM:

229600

Clinical features from OMIM:

229600

Human phenotypes related to Fructose Intolerance:

32 (show all 29)
id Description HPO Frequency HPO Source Accession
1 seizures 32 HP:0001250
2 abdominal pain 32 HP:0002027
3 nausea 32 HP:0002018
4 vomiting 32 HP:0002013
5 lethargy 32 HP:0001254
6 intellectual disability 32 HP:0001249
7 failure to thrive 32 HP:0001508
8 hepatomegaly 32 HP:0002240
9 hypophosphatemia 32 HP:0002148
10 hypoglycemia 32 HP:0001943
11 hyperuricemia 32 HP:0002149
12 hepatic steatosis 32 HP:0001397
13 elevated hepatic transaminases 32 HP:0002910
14 cirrhosis 32 HP:0001394
15 jaundice 32 HP:0000952
16 lactic acidosis 32 HP:0003128
17 coma 32 HP:0001259
18 gastrointestinal hemorrhage 32 HP:0002239
19 proximal renal tubular acidosis 32 HP:0002049
20 metabolic acidosis 32 HP:0001942
21 hyperbilirubinemia 32 HP:0002904
22 proximal tubulopathy 32 HP:0000114
23 glycosuria 32 HP:0003076
24 malnutrition 32 HP:0004395
25 hyperphosphaturia 32 HP:0003109
26 hyperuricosuria 32 HP:0003149
27 bicarbonaturia 32 HP:0003646
28 fructose intolerance 32 HP:0005973
29 transient aminoaciduria 32 HP:0008273

UMLS symptoms related to Fructose Intolerance:


abdominal pain, icterus, lethargy, nausea, seizures, vomiting

GenomeRNAi Phenotypes related to Fructose Intolerance according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased substrate adherent cell growth GR00193-A-1 9.61 MAPK1 CDK2
2 Decreased substrate adherent cell growth GR00193-A-2 9.61 IRAK1 CDK2
3 Decreased substrate adherent cell growth GR00193-A-3 9.61 CDK2 IRAK1 MAPK1
4 Decreased substrate adherent cell growth GR00193-A-4 9.61 MAPK1 CDK2
5 Increased cell death HMECs cells GR00103-A-0 9.1 CDK2 CLU GLUL MAPK1 PTPN1 TF

MGI Mouse Phenotypes related to Fructose Intolerance:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.03 ALG2 CCND3 CDK2 CLU GLUL HP
2 cardiovascular system MP:0005385 10.02 ALG2 CCND3 CDK2 CLU HP IRAK1
3 cellular MP:0005384 10.02 ALG2 CDK2 GLUL HP IRAK1 MANBA
4 immune system MP:0005387 9.85 IRAK1 MANBA MAPK1 PMM2 TRAF3 ALDOB
5 liver/biliary system MP:0005370 9.61 ALDOB CCND3 CDK2 GLUL HP MANBA
6 mortality/aging MP:0010768 9.4 ALDOB ALG2 CCND3 CDK2 GLUL HP

Drugs & Therapeutics for Fructose Intolerance

Drugs for Fructose Intolerance (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 23)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hydrocortisone Approved, Vet_approved Phase 4 50-23-7 5754 657311
2 Pharmaceutical Solutions Phase 4
3 Corticotropin-Releasing Hormone Phase 4
4 Cortisol succinate Phase 4
5 Hormones Phase 4
6 Hydrocortisone 17-butyrate 21-propionate Phase 4
7 Hydrocortisone acetate Phase 4
8 alanine Nutraceutical Phase 2
9
Sorbitol Approved 50-70-4 5780
10
Pancrelipase Approved 53608-75-6
11 insulin
12 Insulin, Globin Zinc
13 Hypoglycemic Agents
14 Alpha 1-Antitrypsin
15 Liver Extracts
16 pancreatin
17 Protein C Inhibitor
18 Calcium polycarbophil
19 Cathartics
20 Gastrointestinal Agents
21 Laxatives
22 Cola Nutraceutical
23 Psyllium Nutraceutical

Interventional clinical trials:

(show all 17)
id Name Status NCT ID Phase
1 Oral Versus Intravenous Rehydration for Prevention of Dehydration in Premature Babies, During the First Days of Life. Completed NCT00715000 Phase 4
2 Imaging the Effect of Experimental Stress on Small and Large Bowel Water During Fructose Absorption Completed NCT01763281 Phase 4
3 Fructose Malabsorption in Northern Norway Completed NCT00555191 Phase 2, Phase 3
4 Investigation of Alanine in Fructose Intolerance: A Dose Ranging Study Unknown status NCT01185210 Phase 2
5 The Effects of Lactose Intolerance on Gastrointestinal Function and Symptoms in a Chinese Population Unknown status NCT01286597
6 Is the Expression of the GLUT5 Specific Fructose Transport Protein Abnormal in Patients With Fructose Intolerance? Completed NCT01705171
7 Metabolic Consequences of Heterozygous Hereditary Fructose Intolerance Completed NCT02979106
8 Endomicroscopy, IBS and Food Intolerance Completed NCT01692613
9 Effect of Fructose on Colonic Microflora Completed NCT00775567
10 The Effect of Probiotics on Lactose Intolerance Completed NCT01593800
11 Glycemic Effects of Honey Completed NCT01371266
12 Anti-hyperglycemic Effect of Short-term Arginyl-fructose Supplementation in Subjects With Pre-diabetes and Newly Diagnosed Type 2 Diabetes: Randomized, Double-blinded, Placebo-controlled Trial. Completed NCT02285231
13 Shear Wave Sonoelastography in Pediatric Liver Fibrosis Recruiting NCT02372682
14 Irritable Bowel Syndrome and Low FODMAP Diet Recruiting NCT02188680
15 Fructose and Lactose Intolerance and Malabsorption in Functional Gastrointestinal Disorders Active, not recruiting NCT02085889
16 Fructose Breath-testing in Irritable Bowel Syndrome (IBS) Not yet recruiting NCT02614313
17 Long Term Fructose Terminated NCT01288495

Search NIH Clinical Center for Fructose Intolerance

Cochrane evidence based reviews: fructose intolerance

Genetic Tests for Fructose Intolerance

Genetic tests related to Fructose Intolerance:

id Genetic test Affiliating Genes
1 Hereditary Fructose Intolerance 24 ALDOB

Anatomical Context for Fructose Intolerance

MalaCards organs/tissues related to Fructose Intolerance:

39
Liver, Testes

Publications for Fructose Intolerance

Articles related to Fructose Intolerance:

(show top 50) (show all 76)
id Title Authors Year
1
Hereditary fructose intolerance mimicking a biochemical phenotype of mucolipidosis: A review of the literature of secondary causes of lysosomal enzyme activity elevation in serum. ( 27797444 )
2017
2
Predictors of response to a low-FODMAP diet in patients with functional gastrointestinal disorders and lactose or fructose intolerance. ( 28233394 )
2017
3
Lactose and Fructose Intolerance in Turkish Children with Chronic Abdominal Pain. ( 27254047 )
2016
4
Relapsing Acute Axonal Neuropathy in Hereditary Fructose Intolerance. ( 27720712 )
2016
5
Molecular Diagnosis of Hereditary Fructose Intolerance: Founder Mutation in a Community from India. ( 25595217 )
2015
6
Self-reported dietary fructose intolerance in irritable bowel syndrome: Proposed diagnostic criteria. ( 25987795 )
2015
7
Aldolase-B knockout in mice phenocopies hereditary fructose intolerance in humans. ( 25637246 )
2015
8
Hereditary fructose intolerance in Brazilian patients. ( 26937407 )
2015
9
Dietary fructose intolerance, fructan intolerance and FODMAPs. ( 24357350 )
2014
10
Fructose intolerance/malabsorption and recurrent abdominal pain in children. ( 25363950 )
2014
11
Optimal Testing for Diagnosis of Fructose Intolerance: Over-dosage Leads to False Positive Intolerance Test. ( 25273127 )
2014
12
Fruit-induced FPIES masquerading as hereditary fructose intolerance. ( 25002667 )
2014
13
Fructose transporters GLUT5 and GLUT2 expression in adult patients with fructose intolerance. ( 24918004 )
2014
14
Fructose intolerance/malabsorption and recurrent abdominal pain in children. ( 24667867 )
2014
15
Transferrin isoelectric focusing and plasma lysosomal enzyme activities in the diagnosis and follow-up of hereditary fructose intolerance. ( 22713622 )
2012
16
Non responsive celiac disease due to coexisting hereditary fructose intolerance. ( 22461154 )
2012
17
Integration of PCR-Sequencing Analysis with Multiplex Ligation-Dependent Probe Amplification for Diagnosis of Hereditary Fructose Intolerance. ( 23430936 )
2012
18
Fatty liver disease and hypertransaminasemia hiding the association of clinically silent Duchenne muscular dystrophy and hereditary fructose intolerance. ( 23114028 )
2012
19
A Novel Frameshift Mutation of the ALDOB Gene in a Korean Girl Presenting with Recurrent Hepatitis Diagnosed as Hereditary Fructose Intolerance. ( 22375183 )
2012
20
Is medical nutrition therapy (MNT) the same for hereditary vs dietary fructose intolerance? ( 20630171 )
2010
21
The biochemical basis of hereditary fructose intolerance. ( 20162364 )
2010
22
Hereditary fructose intolerance: functional study of two novel ALDOB natural variants and characterization of a partial gene deletion. ( 20848650 )
2010
23
Mutations in the promoter region of the aldolase B gene that cause hereditary fructose intolerance. ( 20882353 )
2010
24
Increased prevalence of mutant null alleles that cause hereditary fructose intolerance in the American population. ( 20033295 )
2010
25
Adult hereditary fructose intolerance. ( 19452588 )
2009
26
Different genotypes in a large Italian family with recurrent hereditary fructose intolerance. ( 18188031 )
2008
27
Hereditary fructose intolerance: frequency and spectrum mutations of the aldolase B gene in a large patients cohort from France--identification of eight new mutations. ( 18541450 )
2008
28
Semi-automated, reverse-hybridization detection of multiple mutations causing hereditary fructose intolerance. ( 17292585 )
2007
29
Clinical and genetic analysis for a Chinese family with hereditary fructose intolerance. ( 17955389 )
2007
30
Transferrin hypoglycosylation in hereditary fructose intolerance: using the clues and avoiding the pitfalls. ( 17457694 )
2007
31
Elevated carbohydrate-deficient transferrin (CDT) and its normalization on dietary treatment as a useful biochemical test for hereditary fructose intolerance and galactosemia. ( 17515832 )
2007
32
Aldolase B mutations and prevalence of hereditary fructose intolerance in a Polish population. ( 16406649 )
2006
33
The spectrum of aldolase B (ALDOB) mutations and the prevalence of hereditary fructose intolerance in Central Europe. ( 15880727 )
2005
34
Structure of the thermolabile mutant aldolase B, A149P: molecular basis of hereditary fructose intolerance. ( 15733923 )
2005
35
Six novel alleles identified in Italian hereditary fructose intolerance patients enlarge the mutation spectrum of the aldolase B gene. ( 15532022 )
2004
36
Simple method for detection of mutations causing hereditary fructose intolerance. ( 12638940 )
2002
37
Molecular analysis of the aldolase B gene in patients with hereditary fructose intolerance from Spain. ( 12205126 )
2002
38
Structural and functional analysis of aldolase B mutants related to hereditary fructose intolerance. ( 12417303 )
2002
39
The temperature dependence of activity and structure for the most prevalent mutant aldolase B associated with hereditary fructose intolerance. ( 12464284 )
2002
40
Hereditary fructose intolerance presenting as Reye's-like syndrome: report of one case. ( 11021009 )
2000
41
Functional and molecular modelling studies of two hereditary fructose intolerance-causing mutations at arginine 303 in human liver aldolase. ( 10970798 )
2000
42
Hereditary fructose intolerance and alpha(1) antitrypsin deficiency. ( 10869005 )
2000
43
Alteration of substrate specificity by a naturally-occurring aldolase B mutation (Ala337-->Val) in fructose intolerance. ( 10229688 )
1999
44
Screening for hereditary fructose intolerance mutations by reverse dot-blot. ( 10024431 )
1999
45
[Hereditary fructose intolerance]. ( 10192989 )
1998
46
Hereditary fructose intolerance. ( 9610797 )
1998
47
A newly identified aldolase B splicing mutation (G-->C, 5' intron 5) in hereditary fructose intolerance from New Zealand. ( 8829634 )
1996
48
Neonatal screening for hereditary fructose intolerance: frequency of the most common mutant aldolase B allele (A149P) in the British population. ( 8933337 )
1996
49
Molecular basis of hereditary fructose intolerance: mutations and polymorphisms in the human aldolase B gene. ( 8535439 )
1995
50
Diverse mutations in the aldolase B gene that underlie the prevalence of hereditary fructose intolerance. ( 7717389 )
1995

Variations for Fructose Intolerance

UniProtKB/Swiss-Prot genetic disease variations for Fructose Intolerance:

66 (show all 16)
id Symbol AA change Variation ID SNP ID
1 ALDOB p.Cys135Arg VAR_000551
2 ALDOB p.Ala150Pro VAR_000553 rs1800546
3 ALDOB p.Ala175Asp VAR_000554 rs76917243
4 ALDOB p.Leu257Pro VAR_000555 rs764701775
5 ALDOB p.Arg304Trp VAR_000556 rs555935217
6 ALDOB p.Asn335Lys VAR_000557 rs78340951
7 ALDOB p.Ala338Val VAR_000558 rs77718928
8 ALDOB p.Ile74Thr VAR_020822 rs781023784
9 ALDOB p.Pro185Arg VAR_020824
10 ALDOB p.Val222Phe VAR_020826
11 ALDOB p.Leu229Pro VAR_020827
12 ALDOB p.Arg304Gln VAR_020828 rs145078268
13 ALDOB p.Cys178Arg VAR_058211
14 ALDOB p.Leu284Pro VAR_058212
15 ALDOB p.Arg46Trp VAR_075348 rs41281039
16 ALDOB p.Tyr343His VAR_075349 rs369586696

ClinVar genetic disease variations for Fructose Intolerance:

6 (show all 30)
id Gene Variation Type Significance SNP ID Assembly Location
1 ALDOB NM_000035.3(ALDOB): c.448G> C (p.Ala150Pro) single nucleotide variant Pathogenic rs1800546 GRCh37 Chromosome 9, 104189856: 104189856
2 ALDOB NM_000035.3(ALDOB): c.524C> A (p.Ala175Asp) single nucleotide variant Pathogenic rs76917243 GRCh37 Chromosome 9, 104189780: 104189780
3 ALDOB NM_000035.3(ALDOB): c.865_867delCTT (p.Leu289del) deletion Pathogenic rs118204425 GRCh37 Chromosome 9, 104187257: 104187259
4 ALDOB NM_000035.3(ALDOB): c.720C> A (p.Cys240Ter) single nucleotide variant Pathogenic rs118204426 GRCh37 Chromosome 9, 104187814: 104187814
5 ALDOB NM_000035.3(ALDOB): c.1005C> G (p.Asn335Lys) single nucleotide variant Pathogenic rs78340951 GRCh37 Chromosome 9, 104184181: 104184181
6 ALDOB ALDOB, 7-BP DEL/1-BP INS, 3-PRIME IVS8 indel Pathogenic
7 ALDOB NM_000035.3(ALDOB): c.10C> T (p.Arg4Ter) single nucleotide variant Pathogenic/Likely pathogenic rs118204428 GRCh37 Chromosome 9, 104193160: 104193160
8 ALDOB NM_000035.3(ALDOB): c.178C> T (p.Arg60Ter) single nucleotide variant Pathogenic/Likely pathogenic rs118204429 GRCh37 Chromosome 9, 104192183: 104192183
9 ALDOB ALDOB, IVS6AS, G-A, -1 single nucleotide variant Pathogenic
10 ALDOB NM_000035.3(ALDOB): c.547_552delCTGGTA (p.Leu183_Val184del) deletion Pathogenic rs387906226 GRCh37 Chromosome 9, 104188909: 104188914
11 ALDOB NM_000035.3(ALDOB): c.442T> C (p.Trp148Arg) single nucleotide variant Pathogenic rs118204430 GRCh37 Chromosome 9, 104189862: 104189862
12 ALDOB NM_000035.3(ALDOB): c.1027T> C (p.Tyr343His) single nucleotide variant Pathogenic rs369586696 GRCh37 Chromosome 9, 104184159: 104184159
13 ALDOB NM_000035.3(ALDOB): c.-10-2043_624+62del deletion Pathogenic GRCh37 Chromosome 9, 104188775: 104195222
14 ALDOB NM_000035.3(ALDOB): c.136A> T (p.Arg46Trp) single nucleotide variant Pathogenic rs41281039 GRCh37 Chromosome 9, 104192225: 104192225
15 ALDOB NM_000035.3(ALDOB): c.1013C> T (p.Ala338Val) single nucleotide variant Likely pathogenic rs77718928 GRCh37 Chromosome 9, 104184173: 104184173
16 ALDOB NM_000035.3(ALDOB): c.625-2A> G single nucleotide variant Likely pathogenic rs786204503 GRCh37 Chromosome 9, 104187911: 104187911
17 ALDOB NM_000035.3(ALDOB): c.612T> A (p.Tyr204Ter) single nucleotide variant Pathogenic/Likely pathogenic rs370793608 GRCh38 Chromosome 9, 101426567: 101426567
18 ALDOB NM_000035.3(ALDOB): c.360_363delCAAA (p.Asn120Lysfs) deletion Pathogenic/Likely pathogenic rs387906225 GRCh37 Chromosome 9, 104190767: 104190770
19 ALDOB NM_000035.3(ALDOB): c.324G> A (p.Lys108=) single nucleotide variant Likely pathogenic rs750026492 GRCh37 Chromosome 9, 104192037: 104192037
20 ALDOB NM_000035.3(ALDOB): c.113-1_115delGGTA deletion Likely pathogenic rs786204598 GRCh37 Chromosome 9, 104192246: 104192249
21 ALDOB NM_000035.3(ALDOB): c.865delC (p.Leu289Phefs) deletion Pathogenic rs864309533 GRCh37 Chromosome 9, 104187259: 104187259
22 ALDOB NM_000035.3(ALDOB): c.324+1G> A single nucleotide variant Pathogenic rs764826805 GRCh37 Chromosome 9, 104192036: 104192036
23 ALDOB NM_000035.3(ALDOB): c.888G> A (p.Trp296Ter) single nucleotide variant Likely pathogenic rs1057517133 GRCh37 Chromosome 9, 104187236: 104187236
24 ALDOB NM_000035.3(ALDOB): c.546delA (p.Leu183Trpfs) deletion Likely pathogenic rs1057517091 GRCh37 Chromosome 9, 104188915: 104188915
25 ALDOB NM_000035.3(ALDOB): c.444G> A (p.Trp148Ter) single nucleotide variant Likely pathogenic rs1057516902 GRCh37 Chromosome 9, 104189860: 104189860
26 ALDOB NM_000035.3(ALDOB): c.420delA (p.Asp141Metfs) deletion Likely pathogenic rs1057517421 GRCh38 Chromosome 9, 101427602: 101427602
27 ALDOB NM_000035.3(ALDOB): c.379+1G> A single nucleotide variant Likely pathogenic rs138121153 GRCh37 Chromosome 9, 104190750: 104190750
28 ALDOB NM_000035.3(ALDOB): c.324+2T> A single nucleotide variant Likely pathogenic rs1057516379 GRCh37 Chromosome 9, 104192035: 104192035
29 ALDOB NM_000035.3(ALDOB): c.112+1delG deletion Likely pathogenic rs1057516534 GRCh37 Chromosome 9, 104193057: 104193057
30 ALDOB NM_000035.3(ALDOB): c.911G> A (p.Arg304Gln) single nucleotide variant Likely pathogenic rs145078268 GRCh38 Chromosome 9, 101424931: 101424931

Expression for Fructose Intolerance

Search GEO for disease gene expression data for Fructose Intolerance.

Pathways for Fructose Intolerance

Pathways related to Fructose Intolerance according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.25 CCND3 CDK2 IRAK1 MAPK1 TRAF3
2 11.96 CCND3 CCNH CDK2 MAPK1
3 11.23 CCND3 CDK2 MAPK1 TRAF3
4 10.96 CCND3 CDK2 MAPK1
5 10.68 CDK2 MAPK1

GO Terms for Fructose Intolerance

Cellular components related to Fructose Intolerance according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.61 ALDOB CLU GLUL HP MAPK1 PMM2
2 cyclin-dependent protein kinase holoenzyme complex GO:0000307 8.62 CCND3 CDK2

Biological processes related to Fructose Intolerance according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 platelet degranulation GO:0002576 9.43 CLU SERPINA1 TF
2 positive regulation of receptor-mediated endocytosis GO:0048260 9.16 CLU TF
3 JAK-STAT cascade involved in growth hormone signaling pathway GO:0060397 8.96 MAPK1 PTPN1
4 regulation of insulin receptor signaling pathway GO:0046626 8.62 CCND3 PTPN1

Molecular functions related to Fructose Intolerance according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.55 ALDOB ALG2 CCND3 CCNH CDK2 CLU
2 RNA polymerase II carboxy-terminal domain kinase activity GO:0008353 8.96 CCNH MAPK1

Sources for Fructose Intolerance

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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