MCID: FCH001
MIFTS: 48

Fuchs' Endothelial Dystrophy

Categories: Rare diseases, Eye diseases

Aliases & Classifications for Fuchs' Endothelial Dystrophy

MalaCards integrated aliases for Fuchs' Endothelial Dystrophy:

Name: Fuchs' Endothelial Dystrophy 12 24 41 14
Fuchs Endothelial Corneal Dystrophy 49 24 55 28
Late Hereditary Endothelial Dystrophy 49 55
Endoepithelial Corneal Dystrophy 49 55
Fuchs Endothelial Dystrophy 24 69
Fuchs Corneal Dystrophy 24 36
Fuchs Dystrophy 24 51
Fecd 49 55
Corneal Dystrophy, Fuchs' Endothelial, 1 69
Fuchs' Endothelial Corneal Dystrophy 12
Corneal Dystrophy, Fuchs Endothelial 51
Fuchs' Corneal Dystrophy 12
Fuchs Atrophy 24
Fced 12

Characteristics:

Orphanet epidemiological data:

55
fuchs endothelial corneal dystrophy
Inheritance: Autosomal dominant,Multigenic/multifactorial,Not applicable; Age of onset: Adult;

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Eye diseases
Orphanet: 55  
Rare eye diseases


External Ids:

Disease Ontology 12 DOID:11555
ICD10 32 H18.51
MeSH 41 D005642
NCIt 46 C84721
Orphanet 55 ORPHA98974
UMLS via Orphanet 70 C0016781
ICD10 via Orphanet 33 H18.5
KEGG 36 H00960

Summaries for Fuchs' Endothelial Dystrophy

NIH Rare Diseases : 49 Fuchs endothelial corneal dystrophy (FECD) is an eye disease. It affects the thin layer of cells that line the back part of the cornea. This layer is called the endothelium. The disease occurs when these cells slowly start to die off. The cells help pump excess fluid out of the cornea. As more and more cells are lost, fluid begins to build up in the cornea, causing swelling and a cloudy cornea. There are several forms of the disease according to the age of onset of the symptoms and the cause. The early-onset form is very rare and is known as Fuchs endothelial corneal dystrophy 1 (or early-onset Fuchs endothelial corneal dystrophy) and it is caused by a change (mutation) in the COL8A2 gene. Late-onset Fuchs endothelial corneal dystrophies are common and include:Fuchs endothelial corneal dystrophy 2 (caused by a mutation in an unknown gene located in chromosome13) Fuchs endothelial corneal dystrophy 3 (may be caused by TCF4 gene mutations) Fuchs endothelial corneal dystrophy 4 (caused by a mutation in the SLC4A11 gene) Fuchs endothelial corneal dystrophy 5 (caused by a mutation in an unknown gene located in chromosome 15) Fuchs endothelial corneal dystrophy 6 (caused by a mutation in the ZEB1 gene) Fuchs endothelial corneal dystrophy 7 (caused by a mutation in an unknown gene located in chromosome 9) Fuchs endothelial corneal dystrophy 8 (caused by heterozygous mutation in the AGBL1 gene).  Early in the disease, patients typically do not have symptoms. In the late-onset forms, the symptoms start around 50 or 60 years and include discomfort and painful episodes of recurrent corneal wounds and hazy vision. Over time, discomfort may diminish but severe impairment of visual acuity, and even blindness and cataracts in elderly patients, may be observed. Once the vision has worsened, the recommended treatment is a penetrating graft which has excellent results in most cases. Last updated: 2/3/2016

MalaCards based summary : Fuchs' Endothelial Dystrophy, also known as fuchs endothelial corneal dystrophy, is related to corneal dystrophy, posterior polymorphous, 1 and corneal dystrophy. An important gene associated with Fuchs' Endothelial Dystrophy is COL8A2 (Collagen Type VIII Alpha 2 Chain), and among its related pathways/superpathways are DNA Damage Response (only ATM dependent) and Nanomaterial induced apoptosis. The drugs Loteprednol and Methylprednisolone have been mentioned in the context of this disorder. Affiliated tissues include endothelial and eye, and related phenotype is vision/eye.

Genetics Home Reference : 24 Fuchs endothelial dystrophy is a condition that causes vision problems. The first symptom of this condition is typically blurred vision in the morning that usually clears during the day. Over time, affected individuals lose the ability to see details (visual acuity). People with Fuchs endothelial dystrophy also become sensitive to bright lights.

Disease Ontology : 12 A corneal dystrophy characterized by accumulation of focal outgrowths (guttae) and thickening of Descemet's membrane, leading to corneal edema and loss of vision.

Related Diseases for Fuchs' Endothelial Dystrophy

Diseases related to Fuchs' Endothelial Dystrophy via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 36)
# Related Disease Score Top Affiliating Genes
1 corneal dystrophy, posterior polymorphous, 1 30.5 COL8A2 SLC4A11 VSX1 ZEB1
2 corneal dystrophy 30.2 AGBL1 COL8A2 SLC4A11 TCF4 TGFBI VSX1
3 corneal dystrophy, fuchs endothelial, 3 12.0
4 corneal dystrophy, fuchs endothelial, 1 11.7
5 corneal dystrophy, fuchs endothelial, 2 11.4
6 corneal dystrophy, fuchs endothelial, 4 11.4
7 corneal dystrophy, fuchs endothelial, 6 11.4
8 corneal dystrophy, fuchs endothelial, 5 11.1
9 endotheliitis 10.8
10 glandular cystitis 10.5 KRT20 MUC1
11 epithelial basement membrane dystrophy 10.5 COL8A2 TGFBI
12 corneal dystrophy, endothelial, x-linked 10.5 SLC4A11 VSX1
13 kashin-beck disease 10.5 BAX BCL2
14 corneal dystrophy, thiel-behnke type 10.5 COL8A2 SLC4A11 TGFBI
15 mucinous bronchioloalveolar adenocarcinoma 10.5 KRT20 MUC1
16 corneal endothelial dystrophy 10.5 COL8A2 SLC4A11 TGFBI
17 cartilage-hair hypoplasia 10.5 BAX BCL2 FASLG
18 bile duct carcinoma 10.4 FASLG KRT20 MUC1
19 bile duct cystadenocarcinoma 10.4 KRT20 MUC1
20 intratubular embryonal carcinoma 10.4 KRT20 TCF4
21 corneal dystrophy, posterior polymorphous, 2 10.3 COL8A2 SLC4A11 VSX1 ZEB1
22 corneal dystrophy, posterior polymorphous, 3 10.3 COL8A2 SLC4A11 VSX1 ZEB1
23 basal cell carcinoma 10.3 BAX BCL2 FASLG KRT20
24 central pontine myelinolysis 10.3 AQP1 BCL2
25 renal cell carcinoma, nonpapillary 10.3 CLU FASLG KRT20 MUC1
26 malignant teratoma 10.3 BAX BCL2
27 cataract 10.2
28 keratopathy 10.2
29 bullous keratopathy 10.2
30 corneal degeneration 10.2 TGFBI VSX1
31 keratoconus 10.1
32 corneal disease 10.1 AGBL1 COL8A2 SLC4A11 TGFBI VSX1 ZEB1
33 aging 9.9
34 hydrops, lactic acidosis, and sideroblastic anemia 9.9
35 corneal edema 9.9
36 blepharospasm 9.9

Graphical network of the top 20 diseases related to Fuchs' Endothelial Dystrophy:



Diseases related to Fuchs' Endothelial Dystrophy

Symptoms & Phenotypes for Fuchs' Endothelial Dystrophy

MGI Mouse Phenotypes related to Fuchs' Endothelial Dystrophy:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 vision/eye MP:0005391 9.36 AQP1 BAX BCL2 COL8A2 FASLG PITX2

Drugs & Therapeutics for Fuchs' Endothelial Dystrophy

Drugs for Fuchs' Endothelial Dystrophy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 33)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Loteprednol Approved Phase 4 129260-79-3, 82034-46-6 9865442 444025
2
Methylprednisolone Approved, Vet_approved Phase 4,Phase 2 83-43-2 6741
3
Prednisolone Approved, Vet_approved Phase 4,Phase 2 50-24-8 5755
4 Anti-Allergic Agents Phase 4,Phase 2
5 Antiemetics Phase 4,Phase 2
6 Anti-Inflammatory Agents Phase 4,Phase 2
7 Antineoplastic Agents, Hormonal Phase 4,Phase 2
8 Autonomic Agents Phase 4,Phase 2
9 Gastrointestinal Agents Phase 4,Phase 2
10 glucocorticoids Phase 4,Phase 2
11 Hormone Antagonists Phase 4,Phase 2
12 Hormones Phase 4,Phase 2
13 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2
14 Methylprednisolone acetate Phase 4,Phase 2
15 Methylprednisolone Hemisuccinate Phase 4,Phase 2
16 Neuroprotective Agents Phase 4,Phase 2
17 Ophthalmic Solutions Phase 4,Phase 3
18 Peripheral Nervous System Agents Phase 4,Phase 2
19 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2
20 Prednisolone acetate Phase 4,Phase 2
21 Prednisolone hemisuccinate Phase 4,Phase 2
22 Prednisolone phosphate Phase 4,Phase 2
23 Protective Agents Phase 4,Phase 2
24 Tetrahydrozoline Phase 3
25
Fluorometholone Approved, Investigational Phase 2 426-13-1 9878
26
Dexamethasone Approved, Investigational, Vet_approved Phase 2 50-02-2 5743
27 BB 1101 Phase 2
28 Dexamethasone acetate Phase 2 1177-87-3
29 HIV Protease Inhibitors Phase 2
30
protease inhibitors Phase 2
31
Hyaluronic acid Approved, Vet_approved 9004-61-9 53477741 24759
32 Adjuvants, Immunologic
33 Viscosupplements

Interventional clinical trials:

(show all 35)

# Name Status NCT ID Phase Drugs
1 Fuchs' Torsional Phaco Study Completed NCT00781027 Phase 4
2 Comparison of Corticosteroid Dosing Regimens After Endothelial Keratoplasty Completed NCT01853696 Phase 4 loteprednol etabonate;prednisolone acetate 1%
3 Intrastromal Corneal Ring for High Astigmatism on Postkeratoplasty Completed NCT01018797 Phase 4
4 Glanatec(R) for Descemet Stripping in Fuch's Endothelial Dystrophy Not yet recruiting NCT03249337 Phase 4 Ripasudil hydrochloride hydrate 0.4% ophthalmic solution
5 Trial of Netarsudil for Prevention of Corticosteroid-induced Intraocular Pressure Elevation Recruiting NCT03248037 Phase 3 Netarsudil;Placebo
6 Comparison of Two Steroid Regimens to Prevent Transplant Rejection After Corneal Transplant (DMEK) Completed NCT01448213 Phase 2 Prednisolone acetate;Fluorometholone
7 Immunosuppression During Penetrating Keratoplasty, Using a Subconjunctival Implant Releasing Dexamethasone : Tolerance and Safety Pilot Study Recruiting NCT02834260 Phase 2 Dexamethasone implant OZURDEX
8 The Molecular Pathogenesis of Late-onset Fuchs' Endothelial Corneal Dystrophy Unknown status NCT01795001
9 Comparing Endoglide to Endoserter for DSAEK Graft Insertion Unknown status NCT01791075
10 Comparison of Corneal Grafts Cultured in Serum-free Versus Corneal Grafts Cultured in Serum Supplemented Culture Media Unknown status NCT00623584
11 Cornea Donor Study Unknown status NCT00006411
12 DSAEK- Postoperative Positioning and Transplant Dislocation Unknown status NCT01206127
13 Outcome After Descemet Membrane Endothelial Keratoplasty (DMEK) and Ultra-thin Descemet Stripping Automated Endothelial Keratoplasty (DSAEK) Unknown status NCT02020044
14 Early Experience With Descemet's Stripping Automated Endothelial Keratoplasty Unknown status NCT00744796
15 ODM 5 in the Treatment of Corneal Edematous Fuchs' Endothelial Dystrophy Completed NCT02332109
16 Fuchs' Endothelial Dystrophy: Clinical Characteristics, Treatment Outcome, and Pathology Completed NCT01979250
17 Comparison of Two Techniques in Achieving Corneal Graft Completed NCT01610973
18 Combined Cataract Surgery and Planned Descemetorhexis Completed NCT02206594
19 Long Term Cornea Graft Survival Study Completed NCT02849808
20 Study of Eye Bank Pre-cut Donor Grafts for Endothelial Keratoplasty Completed NCT00624221
21 Impact of Cataract Surgery on Keratoplasty Graft Survival Completed NCT02875145
22 A Comparison Between Full Thickness and Partial Thickness Corneal Transplantation for Corneal Edema Completed NCT00346138
23 PIONEER: Intraoperative and Perioperative OCT Study Completed NCT02423161
24 Evaluation of the Efficacy of Descemet Membrane Transplantation for the Treatment of Fuchs' Endothelial Dystrophy Recruiting NCT03275896 Early Phase 1
25 Assessment of Corneal Graft Attachment in Patients With Fuchs Endothelial Corneal Dystrophy Following DMEK Using Ultra-high Resolution OCT Recruiting NCT02542644
26 DMEK Versus DSAEK Study Recruiting NCT02793310
27 Technique And Results In Endothelial Keratoplasty Recruiting NCT02470793
28 Air Versus SF6 for Descemet's Membrane Endothelial Keratoplasty (DMEK) Recruiting NCT03407755
29 Novel Diagnostics With Optical Coherence Tomography: Imaging the Anterior Eye Recruiting NCT00343473
30 Study of Endothelial Keratoplasty Outcomes Recruiting NCT00800111
31 DISCOVER Study: Microscope-integrated Intraoperative OCT Study Recruiting NCT02423213
32 OCT-guided DSAEK Graft Shaping and Smoothing Suspended NCT01586234
33 Using the Optovue OCT to Select IOL Power Terminated NCT01361282
34 Study of the Effect of Aspheric Lenses in Patients With Fuch's Dystrophy Withdrawn NCT02109276
35 Specular Microscopy Study Withdrawn NCT02478970

Search NIH Clinical Center for Fuchs' Endothelial Dystrophy

Cochrane evidence based reviews: fuchs' endothelial dystrophy

Genetic Tests for Fuchs' Endothelial Dystrophy

Genetic tests related to Fuchs' Endothelial Dystrophy:

# Genetic test Affiliating Genes
1 Fuchs Endothelial Corneal Dystrophy 28

Anatomical Context for Fuchs' Endothelial Dystrophy

MalaCards organs/tissues related to Fuchs' Endothelial Dystrophy:

38
Endothelial, Eye

Publications for Fuchs' Endothelial Dystrophy

Articles related to Fuchs' Endothelial Dystrophy:

(show top 50) (show all 172)
# Title Authors Year
1
Feasibility of cell-based therapy combined with descemetorhexis for treating Fuchs endothelial corneal dystrophy in rabbit model. ( 29338061 )
2018
2
Factors Influencing Visual Acuity in Fuchs' Endothelial Corneal Dystrophy. ( 29252902 )
2018
3
Corneal Optical Changes Associated with Induced Edema in Fuchs Endothelial Corneal Dystrophy. ( 29408827 )
2018
4
NQO1 downregulation potentiates menadione-induced endothelial-mesenchymal transition during rosette formation in Fuchs endothelial corneal dystrophy. ( 29294389 )
2018
5
Fuchs endothelial corneal dystrophy and macular drusen: evidence for coincidence? ( 29350686 )
2018
6
Evolving therapies for Fuchs' endothelial dystrophy. ( 29360003 )
2018
7
Quarter-Descemet membrane endothelial keratoplasty (Quarter-DMEK) for Fuchs endothelial corneal dystrophy: 6 months clinical outcome. ( 29343529 )
2018
8
Regenerative Therapy for Fuchs Endothelial Corneal Dystrophy. ( 29384808 )
2018
9
Trinucleotide Repeat Expansion in the Transcription Factor 4 (TCF4) Gene Leads to Widespread mRNA Splicing Changes in Fuchs' Endothelial Corneal Dystrophy. ( 28118661 )
2017
10
Study of light scattering using C-Quant(Ar) in patients with Fuchs' endothelial dystrophy: A pilot study. ( 28320557 )
2017
11
Sustained Activation of the Unfolded Protein Response Induces Cell Death in Fuchs' Endothelial Corneal Dystrophy. ( 28727885 )
2017
12
Fuchs' Endothelial Corneal Dystrophy and RNA Foci in Patients With Myotonic Dystrophy. ( 28886202 )
2017
13
Corneal Backscatters as an Objective Index for Assessing Fuchs' Endothelial Corneal Dystrophy: A Pilot Study. ( 28751984 )
2017
14
Mini descemet membrane stripping (m-DMES) in patients with Fuchs' endothelial dystrophy: A new method. ( 29234234 )
2017
15
Activation of mitophagy leads to decline in Mfn2 and loss of mitochondrial mass in Fuchs endothelial corneal dystrophy. ( 28751712 )
2017
16
Association of polymorphisms in the intron of TCF4 gene to late-onset Fuchs endothelial corneal dystrophy: An Indian cohort study. ( 29044056 )
2017
17
Peripheral Endothelial Cell Count Is a Predictor of Disease Severity in Advanced Fuchs Endothelial Corneal Dystrophy. ( 28731879 )
2017
18
Activation of TGF-I^ signaling induces cell death via the unfolded protein response in Fuchs endothelial corneal dystrophy. ( 28754918 )
2017
19
Extracellular Matrix and Integrin Expression Profiles in Fuchs Endothelial Corneal Dystrophy Cells and Tissue Model. ( 28726551 )
2017
20
TGC repeat expansion in the TCF4 gene increases the risk of Fuchs' endothelial corneal dystrophy in Australian cases. ( 28832669 )
2017
21
Fuchs' endothelial corneal dystrophy: a controlled prospective study on visual recovery after endothelial keratoplasty. ( 27273977 )
2016
22
Corneal Densitometry, Central Corneal Thickness, and Corneal Central-to-Peripheral Thickness Ratio in Patients With Fuchs Endothelial Dystrophy. ( 26655484 )
2016
23
Preliminary outcome of hemi-Descemet membrane endothelial keratoplasty for Fuchs endothelial dystrophy. ( 26837507 )
2016
24
Author Response: Transforming Growth Factor Beta Switch in Aqueous Humor of Patients With Fuchs' Endothelial Corneal Dystrophy. ( 26927571 )
2016
25
Changes in Corneal Densitometry in Patients with Fuchs Endothelial Dystrophy after Endothelial Keratoplasty. ( 27260144 )
2016
26
Case Report of Quarter-Descemet Membrane Endothelial Keratoplasty for Fuchs Endothelial Dystrophy. ( 27583798 )
2016
27
Interface Fluid Syndrome After Laser In Situ Keratomileusis (LASIK) Because of Fuchs Endothelial Dystrophy Reversed by Descemet Membrane Endothelial Keratoplasty (DMEK). ( 27490052 )
2016
28
In Vivo Imaging of Corneal Endothelial Dystrophy in Boston Terriers: A Spontaneous, Canine Model for Fuchs' Endothelial Corneal Dystrophy. ( 27454658 )
2016
29
The Ultrastructures and Mechanical Properties of the Descement's Membrane in Fuchs Endothelial Corneal Dystrophy. ( 26980551 )
2016
30
Evaluation of Endothelial Pump Function in Fuchs Endothelial Dystrophy Before and After Endothelial Keratoplasty. ( 27055221 )
2016
31
Menadione-Induced DNA Damage Leads to Mitochondrial Dysfunction and Fragmentation During Rosette Formation in Fuchs Endothelial Corneal Dystrophy. ( 26935406 )
2016
32
Changes in Corneal Refractive Power for Patients With Fuchs Endothelial Dystrophy After DMEK. ( 27055217 )
2016
33
Fuchs Endothelial Corneal Dystrophy: A Systematic Immunofluorescence Study of Collagen Type VIII Suggests Heterogeneous Pathophysiology. ( 27078008 )
2016
34
Restoration of Mitochondrial Integrity, Telomere Length, and Sensitivity to Oxidation by In Vitro Culture of Fuchs' Endothelial Corneal Dystrophy Cells. ( 27802523 )
2016
35
Coenzyme Q10 in the Treatment of Corneal Edema in Kearns-Sayre: Is There an Application in Fuchs Endothelial Corneal Dystrophy? ( 27442316 )
2016
36
Racial/Ethnic Differences in Rates of Penetrating or Endothelial Keratoplasty for Fuchs Endothelial Corneal Dystrophy Among US Medicare Beneficiaries. ( 27533017 )
2016
37
Existence of Neural Crest-Derived Progenitor Cells in Normal and Fuchs Endothelial Dystrophy Corneal Endothelium. ( 27639969 )
2016
38
Fuchs endothelial corneal dystrophy: current perspectives. ( 26937169 )
2016
39
Corneal Hydration Control in Fuchs' Endothelial Corneal Dystrophy. ( 27661858 )
2016
40
Treatment of Fuchs Endothelial Dystrophy by Descemet Stripping Without Endothelial Keratoplasty. ( 27310885 )
2016
41
Descemet Stripping Automated Endothelial Keratoplasty in Fuchs' Endothelial Dystrophy versus Pseudophakic Bullous Keratopathy. ( 27994806 )
2016
42
Evaluation of Visual Quality in Patients With Fuchs Endothelial Corneal Dystrophy. ( 27631348 )
2016
43
[TGC Repeats in Intron 2 of the TCF4 Gene have a Good Predictive Power Regarding to Fuchs Endothelial Corneal Dystrophy]. ( 26280645 )
2016
44
Descemet Stripping Endothelial Keratoplasty for Fuchs' Endothelial Corneal Dystrophy: Five-Year Results of a Prospective Study. ( 26481820 )
2015
45
Directional Posterior Corneal Profile Changes in Fuchs' Endothelial Corneal Dystrophy. ( 26348640 )
2015
46
Vision with Fuchs endothelial dystrophy. ( 25856653 )
2015
47
RNA toxicity and missplicing in the common eye disease fuchs endothelial corneal dystrophy. ( 25593321 )
2015
48
The pathophysiology of Fuchs' endothelial dystrophy--a review of molecular and cellular insights. ( 25446318 )
2015
49
Involvement of ZEB1 and Snail1 in excessive production of extracellular matrix in Fuchs endothelial corneal dystrophy. ( 26302187 )
2015
50
FUCHS ENDOTHELIAL CORNEAL DYSTROPHY: IS FEMTOSECOND LASER-ASSISTED CATARACT SURGERY THE RIGHT APPROACH? ( 26978884 )
2015

Variations for Fuchs' Endothelial Dystrophy

Expression for Fuchs' Endothelial Dystrophy

Search GEO for disease gene expression data for Fuchs' Endothelial Dystrophy.

Pathways for Fuchs' Endothelial Dystrophy

GO Terms for Fuchs' Endothelial Dystrophy

Cellular components related to Fuchs' Endothelial Dystrophy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 pore complex GO:0046930 8.62 BAX BCL2

Biological processes related to Fuchs' Endothelial Dystrophy according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 male gonad development GO:0008584 9.69 BAX BCL2 PITX2
2 negative regulation of apoptotic signaling pathway GO:2001234 9.52 BAX BCL2
3 extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 9.5 BAX BCL2 FASLG
4 endoplasmic reticulum calcium ion homeostasis GO:0032469 9.49 BAX BCL2
5 activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway GO:0097296 9.48 BAX FASLG
6 regulation of protein heterodimerization activity GO:0043497 9.46 BAX BCL2
7 cellular response to stress GO:0033554 9.43 AQP1 KRT20
8 regulation of protein homodimerization activity GO:0043496 9.4 BAX BCL2
9 leukocyte homeostasis GO:0001776 9.37 BAX BCL2
10 retinal cell programmed cell death GO:0046666 9.26 BAX FASLG
11 regulation of nitrogen utilization GO:0006808 9.16 BAX BCL2
12 positive regulation of developmental pigmentation GO:0048087 8.96 BAX BCL2
13 release of cytochrome c from mitochondria GO:0001836 8.8 BAX BCL2 CLU

Molecular functions related to Fuchs' Endothelial Dystrophy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 BH3 domain binding GO:0051434 8.96 BAX BCL2
2 channel activity GO:0015267 8.8 AQP1 BAX BCL2

Sources for Fuchs' Endothelial Dystrophy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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