MCID: FCH001
MIFTS: 45

Fuchs' Endothelial Dystrophy malady

Categories: Genetic diseases, Eye diseases, Rare diseases

Aliases & Classifications for Fuchs' Endothelial Dystrophy

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Aliases & Descriptions for Fuchs' Endothelial Dystrophy:

Name: Fuchs' Endothelial Dystrophy 11 24 13 37
Fuchs Endothelial Corneal Dystrophy 46 23 24 52 25
Fecd 46 23 52
Late Hereditary Endothelial Dystrophy 46 52
Endoepithelial Corneal Dystrophy 46 52
Fuchs Endothelial Dystrophy 24 66
Fuchs Dystrophy 24 48
 
Corneal Dystrophy, Fuchs' Endothelial, 1 66
Corneal Dystrophy, Fuchs Endothelial 48
Fuchs' Endothelial Corneal Dystrophy 11
Fuchs' Corneal Dystrophy 11
Fuchs Corneal Dystrophy 24
Fuchs Atrophy 24
Fced 11

Characteristics:

Orphanet epidemiological data:

52
fuchs endothelial corneal dystrophy:
Inheritance: Autosomal dominant,Multigenic/multifactorial,Not applicable; Age of onset: Adult

Classifications:

Orphanet: 52 
Rare eye diseases


External Ids:

Disease Ontology11 DOID:11555
ICD1028 H18.51
MeSH37 D005642
NCIt43 C84721
Orphanet52 ORPHA98974
ICD10 via Orphanet29 H18.5

Summaries for Fuchs' Endothelial Dystrophy

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NIH Rare Diseases:46 Fuchs endothelial corneal dystrophy (fecd) is an eye disease. it affects the thin layer of cells that line the back part of the cornea. this layer is called the endothelium. the disease occurs when these cells slowly start to die off. the cells help pump excess fluid out of the cornea. as more and more cells are lost, fluid begins to build up in the cornea, causing swelling and a cloudy cornea. there are several forms of the disease according to the age of onset of the symptoms and the cause. the early-onset form is very rare and is known as fuchs endothelial corneal dystrophy 1 (or early-onset fuchs endothelial corneal dystrophy) and it is caused by a change (mutation) in the col8a2 gene. late-onset fuchs endothelial corneal dystrophies are common and include:fuchs endothelial corneal dystrophy 2 (caused by a mutation in an unknown gene located in chromosome 13) fuchs endothelial corneal dystrophy 3 (may be caused by tcf4 gene mutations) fuchs endothelial corneal dystrophy 4 (caused by a mutation in the slc4a11 gene) fuchs endothelial corneal dystrophy 5 (caused by a mutation in an unknown gene located in chromosome 15) fuchs endothelial corneal dystrophy 6 (caused by a mutation in the zeb1 gene) fuchs endothelial corneal dystrophy 7 (caused by a mutation in an unknown gene located in chromosome 9) fuchs endothelial corneal dystrophy 8 (caused by heterozygous mutation in the agbl1 gene).  early in the disease, patients typically do not have symptoms. in the late-onset forms, the symptoms start around 50 or 60 years and include discomfort and painful episodes of recurrent corneal wounds and hazy vision. over time, discomfort may diminish but severe impairment of visual acuity, and even blindness and cataracts in elderly patients, may be observed. once the vision has worsened, the recommended treatment is a penetrating graft which has excellent results in most cases. last updated: 2/3/2016

MalaCards based summary: Fuchs' Endothelial Dystrophy, also known as fuchs endothelial corneal dystrophy, is related to corneal dystrophy, fuchs endothelial, 3 and endothelial dystrophy. An important gene associated with Fuchs' Endothelial Dystrophy is COL8A2 (Collagen Type VIII Alpha 2 Chain), and among its related pathways are TP53 network and Vinka Alkaloid Pathway, Pharmacokinetics. Affiliated tissues include endothelial and eye, and related mouse phenotypes are respiratory system and immune system.

Disease Ontology:11 A corneal dystrophy characterized by accumulation of focal outgrowths (guttae) and thickening of descemet's membrane, leading to corneal edema and loss of vision.

Genetics Home Reference:24 Fuchs endothelial dystrophy is a condition that causes vision problems. The first symptom of this condition is typically blurred vision in the morning that usually clears during the day. Over time, affected individuals lose the ability to see details (visual acuity). People with Fuchs endothelial dystrophy also become sensitive to bright lights.

Related Diseases for Fuchs' Endothelial Dystrophy

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Diseases related to Fuchs' Endothelial Dystrophy via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 33)
idRelated DiseaseScoreTop Affiliating Genes
1corneal dystrophy, fuchs endothelial, 311.7
2endothelial dystrophy10.9
3endotheliitis10.9
4desbuquois dysplasia10.6COL8A2, TGFBI
5bacterial esophagitis10.6TGFBI, VSX1
6leber congenital amaurosis10.5COL8A2, TGFBI, VSX1
7angioedema induced by ace inhibitors10.5COL8A2, SLC4A11, VSX1
8iris disease10.5KRT20, MUC1
9metaphyseal dysplasia without hypotrichosis10.5BAX, BCL2, FASLG
10pemphigus vulgaris, familial10.5KRT20, MUC1
11secondary corneal edema10.5COL8A2, SLC4A11, TGFBI
12corneal dystrophy, epithelial basement membrane10.4COL8A2, SLC4A11, TGFBI
13plethora of newborn10.4KRT20, MUC1
14cataract10.3
15tricuspid valve insufficiency10.3KRT20, MUC1
16benign mesenchymoma10.3KRT20, MUC1
17peritoneal serous adenocarcinoma10.3FASLG, KRT20, MUC1
18corneal dystrophy, fuchs endothelial, 110.3
19keratopathy10.3
20bullous keratopathy10.3
21acute serous otitis media10.2COL8A2, MUC1, SLC4A11, TGFBI
22appendix lymphoma10.2KRT20, MUC1
23keratoconus10.2
24corneal dystrophy10.2
25corneal endothelial dystrophy 1, autosomal dominant10.2COL8A2, SLC4A11, VSX1, ZEB1
26adult teratoma10.2BAX, BCL2
27corneal dystrophy, fuchs endothelial, 810.1
28corneal edema9.9
29blepharospasm9.9
30cerebral artery occlusion9.7AGBL1, COL8A2, SLC4A11, TGFBI, VSX1, ZEB1
31retinal drusen9.5AGBL1, COL8A2, SLC4A11, TCF4, TGFBI, VSX1
32chromosome 3q29 microduplication syndrome8.7BCL2, CLU, COL8A2, KRT20, LOXHD1, PITX2
33acute allergic serous otitis media6.4AGBL1, BAX, BCL2, CLU, COL8A1, COL8A2

Graphical network of the top 20 diseases related to Fuchs' Endothelial Dystrophy:



Diseases related to fuchs' endothelial dystrophy

Symptoms for Fuchs' Endothelial Dystrophy

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Drugs & Therapeutics for Fuchs' Endothelial Dystrophy

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Drugs for Fuchs' Endothelial Dystrophy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1glucocorticoidsPhase 4, Phase 24756
2
PrednisolonePhase 4, Phase 2111850-24-85755
Synonyms:
(11beta)-11,17,21-Trihydroxypregna-1,4-diene-3,20-dione
.DELTA.1-Cortisol
.DELTA.1-Dehydrocortisol
.DELTA.1-Dehydrohydrocortisone
.DELTA.1-Hydrocortisone
.delta.-Cortef
.delta.-Stab
1,2-Dehydrohydrocortisone
1,4-Pregnadiene-11beta,17alpha,21-triol-3,20-dione
1,4-Pregnadiene-3,20-dione-11beta,17alpha,21-triol
1-Dehydrocortisol
1-Dehydrohydrocortisone
3,20-dioxo-11beta,17alpha,21-Trihydroxy-1,4-pregnadiene
46656_FLUKA
46656_RIEDEL
50-24-8
58201-11-9
8056-11-9
AC-1773
AC1L1L2E
Ak-Pred
Ak-Tate
Alphadrol
Articulose-50
BPBio1_000164
BRD-K98039984-001-03-0
BRN 1354103
BSPBio_000148
Bio-0666
Bubbli-Pred
C07369
CCRIS 980
CHEBI:8378
CHEMBL131
CID5755
CO-Hydeltra
CPD000718761
Co-Hydeltra
Codelcortone
Cordrol
Cortalone
Cotogesic
Cotolone
D00472
D011239
DB00860
Decaprednil
Decortin H
Delcortol
Delta F
Delta(1)-dehydrohydrocortisone
Delta-Cortef
Delta-Cortef (TN)
Delta-Ef-Cortelan
Delta-Stab
Delta-stab
Deltacortenol
Deltacortril
Deltacortril Enteric
Deltahydrocortisone
Deltasolone
Deltisilone
Depo-Medrol
Derpo PD
Derpo Pd
Dexa-Cortidelt Hostacortin H
Dexa-Cortidelt hostacortin H
Di Adreson F
Di-Adreson F
Di-Adreson-F
Di-adreson F
DiAdresonF
Dicortol
Donisolone
Dydeltrone
EINECS 200-021-7
Eazolin D
Econopred
Econopred Plus
Erbacort
Erbasona
Estilsona
Fernisolone
Fernisolone P
Fernisolone-P
Flamasone
HMS1568H10
HMS2090J05
HSDB 3385
Hostacortin H
Hydeltra
Hydeltra-Tba
Hydeltrasol
Hydeltrone
Hydrodeltalone
Hydrodeltisone
Hydroretrocortin
Hydroretrocortine
I-Pred
Inflamase Forte
Inflamase Mild
K 1557
Key-Pred
Klismacort
LMST02030179
LS-7669
Lentosone
Lite Pred
M-Predrol
 
MLS001304083
MLS002154250
MLS002207037
Medrol
Medrol Acetate
Metacortandralone
Methylprednisolone Acetate
Meti-Derm
Meticortelone
Metreton
MolPort-002-507-147
NCGC00179649-01
NSC 9120
NSC9120
NSC9900
Neo-Delta-Cortef
Nisolone
Nor-Pred T.B.A.
Ocu-Pred
Ocu-Pred Forte
Ophtho-Tate
Orapred
P0152_SIGMA
P0637
P6004_SIGMA
PRDL
PRED-G
Panafcortelone
Paracortol
Paracotol
Pediapred
Poly-Pred
Precortalon
Precortancyl
Precortilon
Precortisyl
Pred Forte
Pred Mild
Predair
Predair A
Predair Forte
Predalone 50
Predalone T.B.A.
Predate
Predate Tba
Predate-50
Predcor-25
Predcor-50
Predcor-Tba
Predisolone Sodium Phosphate
Predne-Dome
Prednelan
Predni-Dome
Prednicen
Predniliderm
Predniretard
Prednis
Prednisolona
Prednisolona [INN-Spanish]
Prednisolone (JP15/USP/INN)
Prednisolone (anhydrous)
Prednisolone Acetate
Prednisolone Sodium Phosphate
Prednisolone Tebutate
Prednisolone [INN:BAN:JAN]
Prednisolonum
Prednisolonum [INN-Latin]
Predonin
Predonine
Prelone
Prenolone
Prestwick0_000274
Prestwick1_000274
Prestwick2_000274
Prestwick3_000274
Prestwick_404
Rolisone
S1737_Selleck
SAM002264639
SMR000718761
SPBio_002367
Scherisolon
Solone
Steran
Sterane
Sterolone
Supercortisol
UNII-9PHQ9Y1OLM
Ulacort
Ultra Pred
Ultracorten H
Ultracortene H
Ultracortene-H
Ultracortene-Hydrogen
Ultracortene-hydrogen
ZINC03833821
component of Ataraxoid
component of K-Predne-Dome
delta(1)-Cortisol
delta(1)-Dehydrocortisol
delta(1)-Dehydrohydrocortisone
delta(1)-Hydrocortisone
delta(sup 1)-Cortisol
delta(sup 1)-Dehydrocortisol
delta(sup 1)-Dehydrohydrocortisone
delta(sup 1)-Hydrocortisone
delta-dehydrocortisol
delta-dehydrohydrocortisone
delta-hydrocortisone
prednisolone
3PREDNISOLONE ACETATEPhase 4, Phase 21118
4
MethylprednisolonePhase 4, Phase 2111883-43-26741
Synonyms:
(6S,8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-6,10,13-trimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one
(6a,11b)-11,17,21-Trihydroxy-6-methylpregna-1,4-diene-3,20-dione
(6alpha,11beta)-11,17,21-Trihydroxy-6-methylpregna-1,4-diene-3,20-dione
(6α,11β)-11,17,21-trihydroxy-6-methylpregna-1,4-diene-3,20-dione
.DELTA.1-6.alpha.-Methylhydrocortisone
1-Dehydro-6alpha-methylhydrocortisone
1-dehydro-6alpha-Methylhydrocortisone
1-dehydro-6α-methylhydrocortisone
11-beta,17,21-Trihydroxy-6-alpha-methylpregna-1,4-diene-3,20-dione
11beta,17,21-Trihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione
11beta,17alpha,21-Trihydroxy-6alpha-methyl-1,4-pregnadiene-3,20-dione
11beta,17alpha,21-Trihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione
121673-01-6
4-08-00-03498 (Beilstein Handbook Reference)
46436_FLUKA
46436_RIEDEL
570-35-4
6 Methylprednisolone
6-Methylprednisolone
6-alpha-Methylprednisolone
6.alpha.-Methylprednisolone
6923-42-8
6alpha-Methyl-11beta,17alpha,21-trihydroxy-1,4-pregnadiene-3,20-dione
6alpha-Methyl-11beta,17alpha,21-triol-1,4-pregnadiene-3,20-dione
6alpha-Methylprednisolone
6alpha-methyl-11beta,17alpha,21-triol-1,4-pregnadiene-3,20-dione
83-43-2
AC1L1N7A
Artisone-Wyeth
Artisone-wyeth
BPBio1_000174
BRD-K35240538-001-03-1
BRN 2340300
BSPBio_000158
Besonia
Bio-0658
CHEBI:6888
CHEMBL650
CID6741
CPD000058330
D00407
D008775
DB00959
Depo-Medrol (acetate)
Dopomedrol
EINECS 201-476-4
Esametone
Firmacort
HMS1568H20
HMS2090B13
HSDB 3127
LMST02030178
LS-118498
Lemod
M0639_SIGMA
M1665
MEPRDL
MLS000028541
MLS001148159
MLS002207191
Medesone
Medixon
Medlone 21
 
Medrate
Medrol
Medrol (TN)
Medrol Adt Pak
Medrol Dosepak
Medrol adt pak
Medrol dosepak
Medrol, Solu-Medrol, Medrone, Methylprednisolone
Medrone
Mesopren
Metastab
Methyleneprednisolone
Methylprednisolon
Methylprednisolone
Methylprednisolone (JP15/USP/INN)
Methylprednisolone [USAN:INN:BAN:JAN]
Methylprednisolone, 6-alpha
Methylprednisolonum
Methylprednisolonum [INN-Latin]
Metilbetasone
Metilprednisolona
Metilprednisolona [INN-Spanish]
Metilprednisolone
Metilprednisolone [DCIT]
Metilprednisolone [Dcit]
Metipred
Metrisone
Metrocort
Metysolon
Moderin
MolPort-002-528-554
NCGC00022735-03
NCI60_001657
NSC-19987
NSC19987
Nirypan
Noretona
Predni N Tablinen
Prednol- L
Pregna-1,4-diene-3,20-dione, 11beta,17,21-trihydroxy-6alpha-methyl- (8CI)
Prestwick0_000279
Prestwick1_000279
Prestwick2_000279
Prestwick3_000279
Prestwick_622
Promacortine
Reactenol
S1733_Selleck
SAM002589984
SMR000058330
SPBio_002377
Sieropresol
Solomet
Summicort
Suprametil
U 7532
UNII-X4W7ZR7023
Urbason
Urbasone
Wyacort
ZINC03875560
delta(1)-6alpha-Methylhydrocortisone
delta(sup 1)-6-alpha-Methylhydrocortisone
methylprednisolone
methylprenisolone
5
LoteprednolPhase 44982034-46-6, 129260-79-3444025, 9865442
Synonyms:
82034-46-6
AC1L9FKJ
AKOS005145741
Alrex
Alrex, Lotemax, Loteprednol etabonate
CDDD-5604
CHEBI:31784
CHEMBL1200865
CID444025
CPD000469178
D01689
DB00873
HGP-1
HMS2051F16
IDR-90102
IDR-90103
Locort
 
Loteflam
Lotemax
Lotemax (TN)
Loteprednol
Loteprednol Etabonate
Loteprednol etabonate
Loteprednol etabonate (JAN/USAN)
Loteprednolum
Loterox
MLS001424221
MolPort-003-848-424
NCGC00164594-01
P-5604
S1669_Selleck
SAM001246630
SMR000469178
ZINC03920673
chloromethyl (8S,9S,10R,11S,13S,14S,17R)-17-ethoxycarbonyloxy-11-hydroxy-10,13-dimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthrene-17-carboxylate
chloromethyl 17alpha-[(ethoxycarbonyl)oxy]-11beta-hydroxy-3-oxoandrosta-1,4-diene-17beta-carboxylate
6
FluorometholonePhase 218426-13-19878
Synonyms:
(1R,2S,8S,10S,11S,14R,15S,17S)-14-acetyl-1-fluoro-14,17-dihydroxy-2,8,15-trimethyltetracyclo[8.7.0.02,7.011,15]heptadeca-3,6-dien-5-one
(6S,8S,9R,10S,11S,13S,14S,17R)-17-acetyl-9-fluoro-11,17-dihydroxy-6,10,13-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
11beta,17alpha-Dihydroxy-9-fluoro-6-methyl-1,4-pregnadiene-3,20-dione
426-13-1
9-Fluoro-11,17-dihydroxy-6-methylpregna-1,4-diene-3,20-dione
9-Fluoro-11-beta,17-dihydroxy-6-alpha-methylpregna-1,4-diene-3,20-dione
9-Fluoro-11beta,17-dihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione
AC-3520
AC1L1U0Y
AI3-52813
Alcon Brand of Fluorometholone
Allergan Brand 1 of Fluorometholone
Allergan Brand 2 of Fluorometholone
Allergan Brand 3 of Fluorometholone
BPBio1_001029
BRD-K64862097-001-03-9
BSPBio_000935
CHEMBL1200600
CID9878
Cortilet
Cortisdin
D005469
D01367
DB00324
Delmeson
EINECS 207-041-5
Efflumidex
F0414
F9381_SIGMA
FML
FML Forte
FML Liquifilm
FML S.O.P
FML-S Liquifilm
Fluaton
Flucon
Flucon, Isopto
Flumetholon
Fluor Op
Fluor-OP
Fluor-Op
Fluor-op (TN)
Fluormetholon
Fluormetholone
Fluormetholonum
Fluoro Ophtal
Fluoro-Ophtal
Fluoromethalone
Fluorometholon
Fluorometholone
 
Fluorometholone (JP15/USP/INN)
Fluorometholone [INN:BAN:JAN]
Fluorometholonum
Fluorometholonum [INN-Latin]
Fluorometolona
Fluorometolona [INN-Spanish]
Fluorometolone
Fluorometolone [DCIT]
Fluorométholone
Fluoropos
Fml (TN)
HMS1570O17
Isdin Brand of Fluorometholone
Isopto Flucon
LS-118455
Loticort
MLS000069537
MLS001076157
MolPort-003-941-413
NCGC00021575-03
NCI60_002886
NSC 33001
NSC-33001
NSC33001
Neo-Oxylone
Novartis Brand of Fluorometholone
Oxylone
Oxylone (TN)
PMS Fluorometholone
PMS-Fluorometholone
Pharm Allergan Brand of Fluorometholone
Pharm-Allergan Brand of Fluorometholone
Pharmascience Brand of Fluorometholone
Pregna-1,4-diene-3,20-dione, 9-fluoro-11.beta.,17
Pregna-1,4-diene-3,20-dione, 9-fluoro-11beta,17-dihydroxy-6alpha-methyl- (8CI)
Prestwick0_000718
Prestwick1_000718
Prestwick2_000718
Prestwick3_000718
Prestwick_227
SMR000058598
SPBio_002856
Trilcin
U 8614
UNII-SV0CSG527L
Ursapharm Brand of Fluorometholone
Ursnon
Winzer Brand of Fluorometholone
ZINC03876158
component of Neo-Oxylone
fluorometholone
7
protease inhibitorsPhase 25157
Synonyms:
 
protease inhibitors
8
DexamethasonePhase 2200150-02-25743
Synonyms:
(3H)-Dexamethasone
.delta.(sup 1)-9-.alpha.-Fluoro-16-.alpha.-methylcortisol
.gamma.corten
1-Dehydro-16.alpha.-methyl-9.alpha.-fluorohydrocortisone
1-Dehydro-16alpha -methyl-9alpha -fluorohydrocortisone
1-Dehydro-16alpha-methyl-9alpha-fluorohydrocortisone
1-Dehydro-16α-methyl-9α-fluorohydrocortisone
137098-19-2
16-alpha-Methyl-9-alpha-fluoro-1-dehydrocortisol
16-alpha-Methyl-9-alpha-fluoro-delta(sup 1)-hydrocortisone
16-alpha-Methyl-9-alpha-fluoro-delta1-hydrocortisone
16-alpha-Methyl-9-alpha-fluoroprednisolone
16.alpha.-Methyl-9.alpha.-fluoro-1-dehydrocortisol
16.alpha.-Methyl-9.alpha.-fluoroprednisolone
16alpha -Methyl-9alpha -fluoro-1-dehydrocortisol
16alpha -Methyl-9alpha -fluoroprednisolone
16alpha-Methyl-9alpha-fluoro-1-dehydrocortisol
16alpha-Methyl-9alpha-fluoro-delta(sup 1)-hydrocortisone
16alpha-Methyl-9alpha-fluoroprednisolone
16α-Methyl-9α-fluoro-1-dehydrocortisol
23495-06-9
31375_FLUKA
46165_FLUKA
46165_RIEDEL
50-02-2
8054-59-9
9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione
9-Fluoro-11alpha -methylpregna-1,4-diene-3,20-dione
9-Fluoro-16-methylprednisolone
9-alpha-Fluoro-16-alpha-methylprednisolone
9.alpha.-Fluoro-16.alpha.-methylprednisolone
906422-84-2
9A-FLUORO-16BETA-METHYLPREDNISOLONE
9alpha -Fluoro-16alpha -methylprednisolone
9alpha-Fluoro-16alpha-methylprednisolone
9alpha-fluoro-16alpha-methyl-Prednisolone
9α-Fluoro-16α-methylprednisolone
AC-11056
AC1L1L1H
AC1Q29DM
AI3-50934
Adexone
Aeroseb-D
Aeroseb-Dex
Aeroseb-dex
Ak Dex Oph Otic Soln 0.1%
Alcon Brand of Dexamethasone
Anaflogistico
Aphtasolon
Aphthasolone
Apo-dexamethasone
Auxiron
Azimycin (veterinary)
Azium
Azium (Veterinary)
Azium (veterinary)
BIDD:ER0494
BIDD:PXR0060
BRD-K38775274-001-02-3
BRD-K38775274-001-06-4
BSPBio_000995
Bisu DS
Bisu Ds
C15643
C22H29FO5
CCRIS 7067
CHEBI:41879
CHEMBL384467
CID5743
CPD-10549
CPD001227192
Calonat
Corson
Corsone
Cortisumman
D00292
D003907
D1756_SIGMA
D4902_SIGMA
D6645_SIGMA
D8893_SIGMA
D9184_SIGMA
DB01234
DEX
DEXA
DEXONE 0.5
DEXONE 0.75
DEXONE 1.5
DEXONE 4
DXM
DXMS
Decacort
Decacortin
Decaderm
Decadron
Decadron (TN)
Decadron Tablets, Elixir
Decadron, Dexamethasone
Decadron-LA
Decadron-La
Decagel
Decaject
Decaject L.A.
Decaject-L.A.
Decalix
Decameth
Decasone
Decaspray
Dectancyl
Dekacort
Delta1-9alpha-Fluoro-16alpha-methylcortisol
Deltafluorene
Dergramin
Deronil
Desadrene
Desametasone
Desametasone [DCIT]
Desametasone [Dcit]
Desamethasone
Desameton
Deseronil
Dex-Ide
Dex-ide
Dexa
Dexa Mamallet
Dexa mamallet
Dexa-Cortidelt
Dexa-Cortisyl
Dexa-Mamallet
Dexa-Scheroson
Dexa-Sine
Dexa-cortidelt
Dexa-cortisyl
Dexa-scheroson
Dexa-sine
Dexacen-4
Dexacidin
Dexacort
Dexacortal
Dexacortin
Dexadeltone
Dexafarma
Dexair
Dexalona
Dexaltin
Dexametasona
Dexametasona [INN-Spanish]
Dexametasone
 
Dexameth
Dexamethansone
Dexamethasone
Dexamethasone (JP15/USP/INN)
Dexamethasone Acetate
Dexamethasone Alcohol
Dexamethasone Base
Dexamethasone Intensol
Dexamethasone Sodium Phosphate
Dexamethasone [INN:BAN:JAN]
Dexamethasone alcohol
Dexamethasone base
Dexamethasone intensol
Dexamethasone-omega
Dexamethasonum
Dexamethasonum [INN-Latin]
Dexamethazone
Dexamonozon
Dexapolcort
Dexapos
Dexaprol
Dexason
Dexasone
Dexasone 0.5mg
Dexasone 0.75mg
Dexasone 4mg
Dexasporin
Dexinolon
Dexinoral
Dexone
Dexone 0.5
Dexone 0.75
Dexone 1.5
Dexone 4
Dexonium
Dexpak
Dextelan
Dezone
Dinormon
Dxms
ECR Brand of Dexamethasone
EINECS 200-003-9
FT-0080377
Fluormethylprednisolone
Fluormone
Fluorocort
Fortecortin
Foy Brand of Dexamethasone
Gammacorten
HL-dex
HMS1792A17
HMS1990A17
HMS2089N13
HSDB 3053
Hexadecadrol
Hexadrol
Hexadrol Elixir
Hexadrol Tablets
Hexadrol elixir
Hl-Dex
Hl-dex
I06-1196
ICN Brand of Dexamethasone
IontoDex
Isopto-Dex
Isopto-dex
LS-7300
Lokalison F
Lokalison f
Loverine
Luxazone
MK 125
MLS001055412
MLS001332507
MLS001332508
Maxidex
Maxidex Ont 0.1%
Maxidex Sus 0.1%
Maxitrol
Mediamethasone
Merck Brand of Dexamethasone
Merz Brand 1 of Dexamethasone
Merz Brand 2 of Dexamethasone
Methylfluorprednisolone
Mexidex
Millicorten
MolMap_000018
MolPort-003-846-433
Mymethasone
NCGC00091019-01
NCGC00091019-02
NCGC00091019-03
NCGC00091019-04
NCGC00091019-05
NCI60_003067
NSC 34521
NSC34521
Naquasone (veterinary)
Neomycin and polymyxin b sulfates and dexamethasone
Neomycin and polymyxin b sulphates and dexamethasone
OTO-104
Ocu-Trol
Ocu-trol
Oradexon
PHL-dexamethasone
PMS-dexamethasone
Pet Derm III
Pet Derm Iii
Pet derm III
Pet-Derm Iii
Pms Dexamethasone Elixir 0.5mg/5ml
Policort
Posurdex
Prednisolon F
Prednisolon f
Prednisolone F
Prednisolone f
Prodex
S1322_Selleck
SAM002548948
SGCUT00126
SK-Dexamethasone
SK-dexamethasone
SMP1_000092
SMR000857119
SMR001227192
ST50307091
Sandoz dexamethasone
Sk-Dexamethasone
Spectrum5_002019
Spoloven
Sunia Sol D
Sunia sol D
Superprednol
TL8003317
Tobradex
Tobramycin and dexamethasone
Tresaderm (veterinary)
Turbinaire
UNII-7S5I7G3JQL
Visumetazone
WLN: L E5 B666 OV KU MUTJ A1 BF CQ E1 FV1Q FQ G1
ZINC03875332
alpha -Fluoro-16-alpha -methylcortisol
delta(Sup 1)-9-alpha-Fluoro-16-alpha-methylcortisol
delta(sup 1)-9-alpha-Fluoro-16-alpha-methylcortisol
delta1-9alpha-Fluoro-16alpha-methylcortisol
dexamethasone
nchembio809-comp2
to_000038
9Dexamethasone acetatePhase 220011177-87-3
10
Hyaluronic acid4199004-61-953477741, 24759
Synonyms:
Hyaluronan
Hyaluronate
Hyaluronic acid
Hylartil
Hyruan Plus
Luronit
 
Macronan
Mucoitin
Nutra-HAF
Q 5AQ
Sepracoat
Sepragel Sinus
Sofast
Synvisc

Interventional clinical trials:

(show all 33)
idNameStatusNCT IDPhase
1Fuchs' Torsional Phaco StudyCompletedNCT00781027Phase 4
2Comparison of Corticosteroid Dosing Regimens After Endothelial KeratoplastyCompletedNCT01853696Phase 4
3Intrastromal Corneal Ring for High Astigmatism on PostkeratoplastyCompletedNCT01018797Phase 4
4Evaluating Results of Neusidl Corneal Inserter in Descemet's Stripping Automated Endothelial Keratoplasty (DSAEK)Active, not recruitingNCT01357122Phase 4
5Comparison of Two Steroid Regimens to Prevent Transplant Rejection After Corneal Transplant (DMEK)CompletedNCT01448213Phase 2
6A Study Investigating the Safety, Tolerability, and Efficacy of Elamipretide Topical Ophthalmic Solution for the Treatment of Fuchs' Corneal Endothelial Dystrophy (FCED)RecruitingNCT02653391Phase 1, Phase 2
7Immunosuppression During Penetrating Keratoplasty, Using a Subconjunctival Implant Releasing Dexamethasone : Tolerance and Safety Pilot StudyNot yet recruitingNCT02834260Phase 2
8Novel Diagnostics With Optical Coherence Tomography: Imaging the Anterior EyeRecruitingNCT00343473Phase 1
9ODM 5 in the Treatment of Corneal Edematous Fuchs' Endothelial DystrophyCompletedNCT02332109
10Fuchs' Endothelial Dystrophy: Clinical Characteristics, Treatment Outcome, and PathologyCompletedNCT01979250
11Study of Eye Bank Pre-cut Donor Grafts for Endothelial KeratoplastyCompletedNCT00624221
12Impact of Cataract Surgery on Keratoplasty Graft SurvivalCompletedNCT02875145
13Combined Cataract Surgery and Planned DescemetorhexisCompletedNCT02206594
14A Comparison Between Full Thickness and Partial Thickness Corneal Transplantation for Corneal EdemaCompletedNCT00346138
15The Molecular Pathogenesis of Late-onset Fuchs' Endothelial Corneal DystrophyRecruitingNCT01795001
16Technique And Results In Endothelial KeratoplastyRecruitingNCT02470793
17DSAEK- Postoperative Positioning and Transplant DislocationRecruitingNCT01206127
18Comparing Endoglide to Endoserter for DSAEK Graft InsertionRecruitingNCT01791075
19DISCOVER Study: Microscope-integrated Intraoperative OCT StudyRecruitingNCT02423213
20Long Term Cornea Graft Survival StudyRecruitingNCT02849808
21Study of Endothelial Keratoplasty OutcomesRecruitingNCT00800111
22Outcome After Descemet Membrane Endothelial Keratoplasty (DMEK) and Ultra-thin Descemet Stripping Automated Endothelial Keratoplasty (DSAEK)RecruitingNCT02020044
23Early Experience With Descemet's Stripping Automated Endothelial KeratoplastyRecruitingNCT00744796
24Specular Microscopy StudyRecruitingNCT02478970
25Comparison of Two Techniques in Achieving Corneal GraftActive, not recruitingNCT01610973
26PIONEER: Intraoperative and Perioperative OCT StudyActive, not recruitingNCT02423161
27Cornea Donor StudyActive, not recruitingNCT00006411
28Using the Optovue OCT to Select IOL PowerEnrolling by invitationNCT01361282
29Assessment of Corneal Graft Attachment in Patients With Fuchs Endothelial Corneal Dystrophy Following DMEK Using Ultra-high Resolution OCTNot yet recruitingNCT02542644
30DMEK Versus DSAEK StudyNot yet recruitingNCT02793310
31Comparison of Corneal Grafts Cultured in Serum-free Versus Corneal Grafts Cultured in Serum Supplemented Culture MediaNot yet recruitingNCT00623584
32OCT-guided DSAEK Graft Shaping and SmoothingSuspendedNCT01586234
33Study of the Effect of Aspheric Lenses in Patients With Fuch's DystrophyWithdrawnNCT02109276

Search NIH Clinical Center for Fuchs' Endothelial Dystrophy


Cochrane evidence based reviews: fuchs' endothelial dystrophy

Genetic Tests for Fuchs' Endothelial Dystrophy

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Genetic tests related to Fuchs' Endothelial Dystrophy:

id Genetic test Affiliating Genes
1 Fuchs Endothelial Corneal Dystrophy25 23

Anatomical Context for Fuchs' Endothelial Dystrophy

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MalaCards organs/tissues related to Fuchs' Endothelial Dystrophy:

34
Endothelial, Eye

Animal Models for Fuchs' Endothelial Dystrophy or affiliated genes

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MGI Mouse Phenotypes related to Fuchs' Endothelial Dystrophy:

39
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.6BAX, BCL2, FASLG, PITX2, PRDX3, PRDX6
2MP:00053878.4BAX, BCL2, CLU, FASLG, PITX2, PRDX2
3MP:00053918.3BAX, BCL2, COL8A1, COL8A2, FASLG, PITX2
4MP:00053848.1BAX, BCL2, COL8A2, FASLG, PITX2, PRDX2

Publications for Fuchs' Endothelial Dystrophy

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Articles related to Fuchs' Endothelial Dystrophy:

(show top 50)    (show all 70)
idTitleAuthorsYear
1
Interface Fluid Syndrome After Laser In Situ Keratomileusis (LASIK) Because of Fuchs Endothelial Dystrophy Reversed by Descemet Membrane Endothelial Keratoplasty (DMEK). (27490052)
2016
2
Preliminary outcome of hemi-Descemet membrane endothelial keratoplasty for Fuchs endothelial dystrophy. (26837507)
2016
3
Case Report of Quarter-Descemet Membrane Endothelial Keratoplasty for Fuchs Endothelial Dystrophy. (27583798)
2016
4
Changes in Corneal Refractive Power for Patients With Fuchs Endothelial Dystrophy After DMEK. (27055217)
2016
5
Existence of Neural Crest-Derived Progenitor Cells in Normal and Fuchs Endothelial Dystrophy Corneal Endothelium. (27639969)
2016
6
Treatment of Fuchs Endothelial Dystrophy by Descemet Stripping Without Endothelial Keratoplasty. (27310885)
2016
7
Corneal Densitometry, Central Corneal Thickness, and Corneal Central-to-Peripheral Thickness Ratio in Patients With Fuchs Endothelial Dystrophy. (26655484)
2016
8
Evaluation of Endothelial Pump Function in Fuchs Endothelial Dystrophy Before and After Endothelial Keratoplasty. (27055221)
2016
9
Unusual Histopathological Views of Fuchs' Endothelial Dystrophy. (26498080)
2015
10
Impact of donor characteristics on 2-year Descemet stripping automated endothelial keratoplasty outcomes in patients with Fuchs endothelial dystrophy. (25393091)
2015
11
The pathophysiology of Fuchs' endothelial dystrophy--a review of molecular and cellular insights. (25446318)
2015
12
Patients with Fuchs Endothelial Dystrophy and Cataract Undergoing Descemet Stripping Automated Endothelial Keratoplasty and Phacoemulsification with Intraocular Lens Implant: Staged versus Combined Procedure Outcomes. (26064669)
2015
13
Vision with Fuchs endothelial dystrophy. (25856653)
2015
14
Objective assessment of the corneal endothelium in Fuchs' endothelial dystrophy. (24508788)
2014
15
Vision-related Quality of Life Before and After Keratoplasty for Fuchs' Endothelial Dystrophy. (25015214)
2014
16
A retrospective study of the association between Fuchs' endothelial dystrophy and glaucoma. (25378902)
2014
17
Corneal Abnormalities Early in the Course ofA Fuchs' Endothelial Dystrophy. (25156138)
2014
18
Intraocular pressure and corneal biomechanics in Fuchs' endothelial dystrophy and after posterior lamellar keratoplasty. (23607620)
2013
19
Retained Descemet's membrane following penetrating keratoplasty for Fuchs' endothelial dystrophy: a case report of a post-operative complication. (23901260)
2013
20
Anterior corneal aberrations after Descemet's stripping endothelial keratoplasty for Fuchs' endothelial dystrophy. (22480739)
2012
21
Association of TCF4 and CLU polymorphisms with Fuchs' endothelial dystrophy and implication of CLU and TGFBI proteins in the disease process. (22234156)
2012
22
Persistent corneal edema after descemetorhexis without corneal graft implantation in a case of fuchs endothelial dystrophy. (21045656)
2011
23
In vivo confocal microscopy of combined pre-descemet membrane corneal dystrophy and fuchs endothelial dystrophy. (20847662)
2011
24
Approaching cataract surgery in patients with fuchs' endothelial dystrophy. (20057291)
2010
25
Descemet's stripping automated endothelial keratoplasty and penetrating keratoplasty for Fuchs' endothelial dystrophy. (19302079)
2009
26
Decreased expression of peroxiredoxins in Fuchs' endothelial dystrophy. (18378575)
2008
27
Simultaneous phacoemulsification and DSEK in patients with concomitant cataract and bullous keratopathy due to Fuchs endothelial dystrophy. (18812092)
2008
28
Increased clusterin expression in Fuchs' endothelial dystrophy. (18378577)
2008
29
Posterior mushroom keratoplasty in patients with Fuchs endothelial dystrophy and pseudophakic bullous keratopathy: transplant outcome. (18580259)
2008
30
Effectiveness of the soft-shell technique in patients with Fuchs' endothelial dystrophy. (17964396)
2007
31
A novel PITX2 mutation and a polymorphism in a 5-generation family with Axenfeld-Rieger anomaly and coexisting Fuchs' endothelial dystrophy. (16876867)
2006
32
Potential complications of ocular surgery in patients with coexistent keratoconus and Fuchs' endothelial dystrophy. (16996603)
2006
33
Cataract extraction in eyes with Fuchs' endothelial dystrophy in China. (16098269)
2005
34
Corneal decompensation after laser in situ keratomileusis in fuchs' endothelial dystrophy. (12792486)
2003
35
Fuchs' endothelial dystrophy: a fresh look at an aging disease. (10627840)
1999
36
Confocal microscopy in cornea guttata and Fuchs' endothelial dystrophy. (10396196)
1999
37
In vivo confocal microscopy of Fuchs' endothelial dystrophy. (9756443)
1998
38
Long-term results after penetrating keratoplasty for Fuchs' endothelial dystrophy. (8540845)
1996
39
Diagnosis of advanced Fuchs' endothelial dystrophy with the confocal microscope. (8238235)
1993
40
Blepharospasm and Fuchs' endothelial dystrophy. (8119439)
1993
41
Fuchs' endothelial dystrophy of the cornea. (8235998)
1993
42
Keratoconus and Fuchs' endothelial dystrophy. (1889226)
1991
43
Cytochrome oxidase activity of Fuchs' endothelial dystrophy. (3026733)
1986
44
Long term results of corneal grafting in Fuchs' endothelial dystrophy. (6380203)
1984
45
Characterization of the Descemet's membrane/posterior collagenous layer isolated from Fuchs' endothelial dystrophy corneas. (6389163)
1984
46
On the significance of a low endothelial cell density in Fuchs' endothelial dystrophy. A specular microscopic study. (6967672)
1980
47
Bullous keratopathy (Fuchs' endothelial dystrophy) treated systemically with 4-trans-amino-cyclohexano-carboxylic acid. (302548)
1977
48
Inheritance of Fuchs' endothelial dystrophy. (5313141)
1971
49
Fate of successful corneal grafts in Fuchs' endothelial dystrophy. (4900890)
1969
50
THE FINE STRUCTURE OF THE CORNEA IN FUCHS' ENDOTHELIAL DYSTROPHY. (14121146)
1964

Variations for Fuchs' Endothelial Dystrophy

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Clinvar genetic disease variations for Fuchs' Endothelial Dystrophy:

5
id Gene Variation Type Significance SNP ID Assembly Location
1COL8A2NM_005202.3(COL8A2): c.1363C> A (p.Gln455Lys)single nucleotide variantPathogenicrs80358191GRCh37Chr 1, 36563919: 36563919
2COL8A2NM_005202.3(COL8A2): c.1349T> G (p.Leu450Trp)single nucleotide variantPathogenicrs80358192GRCh37Chr 1, 36563933: 36563933

Expression for genes affiliated with Fuchs' Endothelial Dystrophy

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Search GEO for disease gene expression data for Fuchs' Endothelial Dystrophy.

Pathways for genes affiliated with Fuchs' Endothelial Dystrophy

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GO Terms for genes affiliated with Fuchs' Endothelial Dystrophy

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Cellular components related to Fuchs' Endothelial Dystrophy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1pore complexGO:004693010.7BAX, BCL2
2mitochondrial membraneGO:003196610.4BAX, BCL2, CLU
3extracellular matrixGO:00310129.8CLU, COL8A1, COL8A2, TGFBI
4extracellular exosomeGO:00700627.6BAX, CLU, COL8A1, FASLG, MUC1, PRDX2

Biological processes related to Fuchs' Endothelial Dystrophy according to GeneCards Suite gene sharing:

(show all 23)
idNameGO IDScoreTop Affiliating Genes
1retinal cell programmed cell deathGO:004666610.6BAX, FASLG
2regulation of nitrogen utilizationGO:000680810.6BAX, BCL2
3regulation of protein homodimerization activityGO:004349610.6BAX, BCL2
4positive regulation of developmental pigmentationGO:004808710.6BAX, BCL2
5apoptotic mitochondrial changesGO:000863710.6BAX, BCL2
6leukocyte homeostasisGO:000177610.6BAX, BCL2
7activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathwayGO:009729610.6BAX, FASLG
8endoplasmic reticulum calcium ion homeostasisGO:003246910.5BAX, BCL2
9B cell homeostasisGO:000178210.5BAX, BCL2
10negative regulation of apoptotic signaling pathwayGO:200123410.4BAX, BCL2
11regulation of protein heterodimerization activityGO:004349710.4BAX, BCL2
12epithelial cell proliferationGO:005067310.4COL8A1, COL8A2
13cellular response to reactive oxygen speciesGO:003461410.3PRDX3, PRDX5
14regulation of mitochondrial membrane potentialGO:005188110.2BAX, BCL2, PRDX3
15extrinsic apoptotic signaling pathway via death domain receptorsGO:000862510.1BAX, BCL2, FASLG
16hydrogen peroxide catabolic processGO:004274410.0PRDX2, PRDX3, PRDX6
17release of cytochrome c from mitochondriaGO:000183610.0BAX, BCL2, CLU
18male gonad developmentGO:00085849.9BAX, BCL2, PITX2
19cellular oxidant detoxificationGO:00988699.9PRDX3, PRDX5, PRDX6
20response to oxidative stressGO:00069799.6BCL2, PRDX2, PRDX3, PRDX5
21response to reactive oxygen speciesGO:00003029.6PRDX2, PRDX3, PRDX5, PRDX6
22cell redox homeostasisGO:00454549.2PRDX2, PRDX3, PRDX5, PRDX6
23apoptotic processGO:00069158.8BAX, BCL2, FASLG, KRT20, PRDX3, PRDX5

Molecular functions related to Fuchs' Endothelial Dystrophy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1BH3 domain bindingGO:005143410.0BAX, BCL2
2channel activityGO:001526710.0BAX, BCL2
3thioredoxin peroxidase activityGO:00083799.9PRDX2, PRDX3, PRDX5

Sources for Fuchs' Endothelial Dystrophy

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet