Fucosyltransferase Deficiency malady

MalaCards: Fucosyltransferase Deficiency, also known as malnutrition, is related to cytomegalovirus infection and herpes simplex. An important gene associated with Fucosyltransferase Deficiency is FUT6 (fucosyltransferase 6 (alpha (1,3) fucosyltransferase)), and among its related pathways is Glycosphingolipid biosynthesis - lacto and neolacto series. The compounds n-acetyllactosamine and slex have been mentioned in the context of this disorder.

fucosyltransferase deficiency 7 malnutrition 43

Disease types for fucosyltransferase deficiency family:

fucosyltransferase-6 deficiency

Diseases related to fucosyltransferase deficiency by text searches and GeneDecks gene sharing:

(show top 50)    (show all 315)

id	Related Disease	Score	Top Affiliating Genes
1	cytomegalovirus infection	12.2	FUT3, FUT6
2	herpes simplex	12.1	FUT3, FUT6
3	lung carcinoma	12.1	FUT3, FUT6
4	colon carcinoma	11.8	FUT3, FUT6
5	protein-energy malnutrition	8.9
6	peritonitis	7.5
7	fucosyltransferase-6 deficiency	6.9
8	atherosclerosis	6.5
9	diabetes mellitus	6.5
10	alcoholism	6.3
11	hepatitis	6.3
12	schizophrenia	6.0
13	anemia	6.0
14	anorexia nervosa	6.0
15	pancreatitis	6.0
16	carcinoma	5.6
17	diarrhea	5.6
18	insulin resistance	5.6
19	rickets	5.6
20	uremia	5.6
21	chronic obstructive pulmonary disease	5.1
22	cystic fibrosis	5.1
23	fibrosis	5.1
24	hyperhomocysteinemia	5.1
25	immunodeficiency	5.1
26	kwashiorkor	5.1
27	liver cirrhosis	5.1
28	marasmus	5.1
29	nutritional deficiency disease	5.1
30	overnutrition	5.1
31	pulmonary disease	5.1
32	ancylostomiasis	5.1
33	3-hydroxyacyl-coa dehydrogenase deficiency	4.2
34	alpha-antichymotrypsin deficiency	4.2
35	autoimmune polyendocrine syndrome type 1	4.2
36	cblg	4.2
37	chitotriosidase deficiency	4.2
38	crohn's disease	4.2
39	dna ligase i deficiency	4.2
40	factor xiiia deficiency	4.2
41	glycogen storage disease ii	4.2
42	huntington disease-like 2	4.2
43	inherited thyroxine-binding globulin deficiency	4.2
44	leukemia	4.2
45	microcephaly	4.2
46	neutral endopeptidase deficiency	4.2
47	pili torti	4.2
48	roberts syndrome	4.2
49	surfactant deficiency	4.2
50	tay-sachs disease	4.2

Approved drugs:

Drug clinical trials:

Articles related to fucosyltransferase deficiency:

id	Title	Authors	Year	Affiliating Genes
1	Molecular analysis of plasma alpha 1,3-fucosyltransferase deficiency and development of the methods for its genotyping. (11150848)	Tanaka S.... Matta K.L.	2001	FUT6
2	Plasma alpha1,3-fucosyltransferase deficiency in schizophrenia. (10394050)	Yazawa S.... Kochibe N.	1999	FUT3, FUT6

Genes related to fucosyltransferase deficiency according to GeneCards:

id	Symbol	Description	Score	GeneCards Section Context
1	FUT6	fucosyltransferase 6 (alpha (1,3) fucosyltransferase)	11.0	UniProt Related, Publications
2	FUT3	fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group)	11.0	Publications

Pathways related to fucosyltransferase deficiency according to GeneDecks:

id	Pathway	Score	Top Affiliating Genes
1	Glycosphingolipid biosynthesis - lacto and neolacto series20	9.1	FUT3, FUT6

Compounds related to fucosyltransferase deficiency according to GeneDecks:

id	Compound	Score	Top Affiliating Genes
1	n-acetyllactosamine32 18	10.1	FUT3, FUT6
2	slex32	8.8	FUT3, FUT6

Cellular components related to fucosyltransferase deficiency according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	Golgi cisterna membrane	GO:032580	9.1	FUT3, FUT6

Biological processes related to fucosyltransferase deficiency according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	protein glycosylation	GO:006486	9.1	FUT3, FUT6
2	fucosylation	GO:036065	8.8	FUT3, FUT6

Molecular functions related to fucosyltransferase deficiency according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	fucosyltransferase activity	GO:008417	9.1	FUT3, FUT6
2	3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity	GO:017060	9.0	FUT3, FUT6
3	alpha-(1->3)-fucosyltransferase activity	GO:046920	8.8	FUT3, FUT6