MCID: FNC002
MIFTS: 36

Functional Diarrhea

Categories: Gastrointestinal diseases

Aliases & Classifications for Functional Diarrhea

MalaCards integrated aliases for Functional Diarrhea:

Name: Functional Diarrhea 12 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:11371
ICD10 32 K59.1
ICD9CM 34 564.5
SNOMED-CT 64 47812002
UMLS 69 C0156173

Summaries for Functional Diarrhea

MalaCards based summary : Functional Diarrhea is related to irritable bowel syndrome and constipation, and has symptoms including vomiting following gastrointestinal surgery, diarrhea and constipation. An important gene associated with Functional Diarrhea is ITM2B (Integral Membrane Protein 2B), and among its related pathways/superpathways are Serotonergic synapse and Farnesoid X Receptor Pathway. The drugs Loperamide and Baclofen have been mentioned in the context of this disorder. Affiliated tissues include colon, and related phenotypes are behavior/neurological and growth/size/body region

Related Diseases for Functional Diarrhea

Diseases related to Functional Diarrhea via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 56)
# Related Disease Score Top Affiliating Genes
1 irritable bowel syndrome 29.2 HTR3A HTR4 HTR7 TAC1
2 constipation 28.9 HTR3A HTR4 TAC1
3 fungal esophagitis 10.5 ATP12A ATP4A
4 bladder calculus 10.5 ATP12A ATP4A
5 gastrointestinal neuroendocrine benign tumor 10.5 ATP12A ATP4A
6 gastric neuroendocrine neoplasm 10.5 ATP12A ATP4A
7 neonatal candidiasis 10.5 ATP12A ATP4A
8 photoallergic dermatitis 10.5 ATP12A ATP4A
9 squamous papillomatosis 10.5 ATP12A ATP4A
10 acute laryngitis 10.5 ATP12A ATP4A
11 gastroduodenal crohn's disease 10.5 ATP12A ATP4A
12 toxic megacolon 10.5 ATP12A ATP4A
13 aspiration pneumonitis 10.5 ATP12A ATP4A
14 gastric antral vascular ectasia 10.5 ATP12A ATP4A
15 esophageal candidiasis 10.5 ATP12A ATP4A
16 postsurgical hypothyroidism 10.5 ATP12A ATP4A
17 laryngeal disease 10.4 ATP12A ATP4A
18 duodenitis 10.4 ATP12A ATP4A
19 congenital disorder of deglycosylation 10.4 ATP12A ATP4A
20 bile reflux 10.4 ATP12A ATP4A
21 granulomatous gastritis 10.4 ATP12A ATP4A
22 active peptic ulcer disease 10.4 ATP12A ATP4A
23 dyskinesia of esophagus 10.4 ATP12A ATP4A
24 ischemic neuropathy 10.4 ATP12A ATP4A
25 capillary disease 10.4 ATP12A ATP4A
26 peptic esophagitis 10.4 ATP12A ATP4A
27 lateral medullary syndrome 10.4 ATP12A ATP4A MRPS22
28 duodenal disease 10.4 ATP12A ATP4A
29 hernia, hiatus 10.3 ATP12A ATP4A
30 superior mesenteric artery syndrome 10.3 ATP12A ATP4A HTR3A
31 esophageal atresia/tracheoesophageal fistula 10.3 ATP12A ATP4A
32 laryngitis 10.3 ATP12A ATP4A
33 laryngeal tuberculosis 10.3 ATP12A ATP4A
34 lymphocytic colitis 10.2 ATP12A ATP4A
35 bulimia nervosa 1 10.2 GHRL HTR3A HTR7
36 motion sickness 10.2 HTR3A HTR7 TAC1
37 chronic intestinal vascular insufficiency 10.2 ATP12A ATP4A
38 anismus 10.2 ATP12A ATP4A TAC1
39 aspiration pneumonia 10.2 ATP12A ATP4A TAC1
40 rumination disorder 10.2 ATP12A ATP4A HTR3A HTR7
41 pain agnosia 10.2 HTR7 NTS TAC1
42 agnosia 10.2 HTR7 NTS TAC1
43 paine syndrome 10.2 ATP12A ATP4A TAC1
44 glomangiosarcoma 10.2 DNTT TAC1
45 clostridium difficile colitis 10.1 ATP12A ATP4A
46 diarrhea 10.1
47 specific developmental disorder 10.1 GHRL HTR7 TAC1
48 lower urinary tract calculus 10.0 ATP12A ATP4A
49 pylorospasm 9.9 GHRL HTR4
50 pancreatic steatorrhea 9.9 ATP12A ATP4A GHRL TAC1

Comorbidity relations with Functional Diarrhea via Phenotypic Disease Network (PDN):


Acute Cystitis Heart Disease

Graphical network of the top 20 diseases related to Functional Diarrhea:



Diseases related to Functional Diarrhea

Symptoms & Phenotypes for Functional Diarrhea

UMLS symptoms related to Functional Diarrhea:


vomiting following gastrointestinal surgery, diarrhea, constipation

MGI Mouse Phenotypes related to Functional Diarrhea:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.96 GHRL HTR3A HTR4 HTR7 ITM2B NR1H4
2 growth/size/body region MP:0005378 9.93 TOR1A ATP12A CDH1 CDK5RAP2 FGF19 GPBAR1
3 homeostasis/metabolism MP:0005376 9.83 ATP12A ATP4A CDH1 DNTT FGF19 GHRL
4 adipose tissue MP:0005375 9.8 GHRL GPBAR1 HTR4 NR1H4 NTS PIK3C2A
5 immune system MP:0005387 9.32 ATP4A CDH1 CDK5RAP2 DNTT GPBAR1 HTR3A

Drugs & Therapeutics for Functional Diarrhea

Drugs for Functional Diarrhea (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 23)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Loperamide Approved Phase 2, Phase 3 53179-11-6 3955
2
Baclofen Approved Phase 3 1134-47-0 2284
3
Desipramine Approved, Investigational Phase 3 50-47-5 2995
4 Gastrointestinal Agents Phase 2, Phase 3,Phase 1
5 Neurotransmitter Agents Phase 3,Phase 1
6 Antidiarrheals Phase 2, Phase 3
7 Adrenergic Agents Phase 3
8 Antidepressive Agents Phase 3
9 Antidepressive Agents, Tricyclic Phase 3
10 Neurotransmitter Uptake Inhibitors Phase 3
11 Proton pump inhibitors Phase 3
12 Psychotropic Drugs Phase 3
13
Citric Acid Approved, Nutraceutical, Vet_approved Phase 1 77-92-9 311
14 Mosapride Investigational Phase 1 112885-41-3
15 Anticoagulants Phase 1
16 Calcium, Dietary Phase 1
17 Chelating Agents Phase 1
18
Serotonin Phase 1 50-67-9 5202
19 Serotonin Agents Phase 1
20 Citrate Nutraceutical Phase 1
21 Acidophilus Nutraceutical
22 Bifidobacterium Nutraceutical
23 Cola Nutraceutical

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Acupuncture for Patients With Diarrhea-predominant IBS or Functional Diarrhea: a Randomized Controlled Trial Completed NCT01350570 Phase 2, Phase 3 Loperamide
2 A Randomized Trial of Medical and Surgical Treatments for Patients With GERD Symptoms That Are Refractory to Proton Pump Inhibitors Completed NCT01265550 Phase 3 baclofen;Desipramine
3 Trial for Quantity-Effect Relationship of Acupuncture With Two-ways Regulation to Treat Functional Enteropathy Unknown status NCT01274793 Phase 1 Mosapride Citrate tablet
4 Chronic Administration of Diosmectite (SMECTA®) in Subjects With Chronic Diarrhoea Completed NCT03045926 Phase 1 Diosmectite (Smecta®)
5 Efficacy of Probiotic Bacteria in Subjects With IBS or Functional Diarrhea/ Bloating Completed NCT00618904
6 Gluten Intolerance in Patients With Diarrhea Predominant Irritable Bowel Syndrome Completed NCT01094041

Search NIH Clinical Center for Functional Diarrhea

Genetic Tests for Functional Diarrhea

Anatomical Context for Functional Diarrhea

MalaCards organs/tissues related to Functional Diarrhea:

38
Colon

Publications for Functional Diarrhea

Articles related to Functional Diarrhea:

(show all 15)
# Title Authors Year
1
Early weaning stress induces chronic functional diarrhea, intestinal barrier defects, and increased mast cell activity in a porcine model of early life adversity. ( 28573751 )
2017
2
Electroacupuncture for patients with diarrhea-predominant irritable bowel syndrome or functional diarrhea: A randomized controlled trial. ( 27310980 )
2016
3
Influence of acupuncture stimulation on cerebral network in functional diarrhea. ( 24459533 )
2013
4
Epidemiology of functional diarrhea and comparison with diarrhea-predominant irritable bowel syndrome: a population-based survey in China. ( 22937091 )
2012
5
Functional diarrhea. ( 22917168 )
2012
6
Development of functional diarrhea, constipation, irritable bowel syndrome, and dyspepsia during and after traveling outside the USA. ( 17549631 )
2008
7
Treatment of functional diarrhea. ( 16836952 )
2006
8
Functional diarrhea. ( 16168232 )
2005
9
Effects of probiotic administration upon the composition and enzymatic activity of human fecal microbiota in patients with irritable bowel syndrome or functional diarrhea. ( 11686387 )
2001
10
Inhibition of gastric secretion relieves diarrhea and postprandial urgency associated with irritable bowel syndrome or functional diarrhea. ( 10505731 )
1999
11
Rapid gastric emptying in patients with functional diarrhea. ( 9121178 )
1997
12
Colonic motility and functional diarrhea. ( 1622483 )
1992
13
Effect of eating on colonic motility and transit in patients with functional diarrhea. Simultaneous scintigraphic and manometric evaluations. ( 1936800 )
1991
14
Functional diarrhea: an analysis of the clinical and roentgen manifestations. ( 13397691 )
1956
15
Alterations in colonic function in man under stress; hypomotility of the sigmoid colon, and its relationship to the mechanism of functional diarrhea. ( 15421433 )
1950

Variations for Functional Diarrhea

Expression for Functional Diarrhea

Search GEO for disease gene expression data for Functional Diarrhea.

Pathways for Functional Diarrhea

Pathways related to Functional Diarrhea according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.18 HTR3A HTR4 HTR7
2 10.54 FGF19 NR1H4
3 10.43 HTR4 HTR7
4 10.25 HTR3A HTR4 HTR7

GO Terms for Functional Diarrhea

Cellular components related to Functional Diarrhea according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 axon GO:0030424 9.26 GHRL HTR3A RAB11A TAC1
2 transport vesicle GO:0030133 8.8 NTS RAB11A TOR1A

Biological processes related to Functional Diarrhea according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chemical synaptic transmission GO:0007268 9.56 HTR3A HTR4 HTR7 TAC1
2 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 9.32 ATP12A ATP4A
3 negative regulation of tumor necrosis factor secretion GO:1904468 9.16 GHRL NR1H4
4 positive regulation of adipose tissue development GO:1904179 8.96 GHRL NR1H4
5 negative regulation of bile acid biosynthetic process GO:0070858 8.62 FGF19 NR1H4

Molecular functions related to Functional Diarrhea according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 serotonin binding GO:0051378 9.26 HTR3A HTR7
2 sodium:potassium-exchanging ATPase activity GO:0005391 9.16 ATP12A ATP4A
3 hydrogen:potassium-exchanging ATPase activity GO:0008900 8.96 ATP12A ATP4A
4 bile acid receptor activity GO:0038181 8.62 GPBAR1 NR1H4

Sources for Functional Diarrhea

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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