MCID: FNC007
MIFTS: 43

Functioning Pituitary Adenoma malady

Summaries for Functioning Pituitary Adenoma

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33MalaCards
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MalaCards: Functioning Pituitary Adenoma, also known as secretory adenoma of the pituitary gland, is related to adenoma and pituitary apoplexy. An important gene associated with Functioning Pituitary Adenoma is SSTR5 (somatostatin receptor 5), and among its related pathways are Monoamine GPCRs and Amphetamine addiction. The compounds noc-ate and [111in]dota-noc have been mentioned in the context of this disorder. Related mouse phenotypes are endocrine/exocrine gland and adipose tissue.

Aliases & Classifications for Functioning Pituitary Adenoma

Sources:
8Disease Ontology, 61UMLS, 40NCIt
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Aliases & Descriptions:

functioning pituitary adenoma 8
secretory adenoma of the pituitary gland 8
pituitary adenoma, functioning 61


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Disease Ontology8 DOID:5395
NCIt40 C8388

Related Diseases for Functioning Pituitary Adenoma

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Functioning Pituitary Adenoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 119)
idRelated DiseaseScoreTop Affiliating Genes
1adenoma31.5PTPN3, GNRH1, GNAS, DRD2, CGA, GH1
2pituitary apoplexy30.7GNRH1, POMC
3growth hormone deficiency30.4POMC, GH1
4acth-secreting pituitary adenoma30.2POMC, GH1
5cushing's syndrome30.2POMC, SST, GH1
6adenocarcinoma30.2SCGN, SSTR2, SSTR1, SST, HMGA2, ADM
7hyperprolactinemia30.1GNAS, GNRH1, DRD2, CGA, GH1, SST
8acromegaly30.1POMC, SST, SSTR1, SSTR2, SSTR5, GH1
9pituitary tumors30.1GNRH1, GNAS, DRD2, GH1, SSTR5, POMC
10prolactinoma30.1GNRH1, GNAS, CORT, SSTR3, SST, SSTR4
11functionless pituitary adenoma10.4
12somatostatin analog10.4
13non-functioning pituitary adenoma10.3
14diaphragma sellae meningioma10.1
15growth hormone secreting pituitary adenoma10.1
16gangliocytoma10.1
17lymphocytic hypophysitis10.1
18granulomatous hypophysitis10.1
19headache10.1
20thyroid adenoma10.1
21lip disease10.1
22pancreatitis10.0SST
23osteomalacia10.0GNAS
24diabetic retinopathy10.0ADM
25multiple endocrine neoplasia10.0GNAS
26turner syndrome10.0GNRH1
27endogenous depression10.0POMC
28goiter10.0GNAS
29leukemia10.0HMGA2
30panic disorder10.0POMC
31hypogonadotropism10.0GNRH1
32paraganglioma10.0SST, SSTR2
33rheumatic fever10.0POMC
34drug dependence10.0DRD2
35phaeochromocytoma10.0ADM
36lung cancer10.0POMC, SST
37noonan syndrome10.0PTPN3
38vipoma10.0GH1, SST
39meningioma10.0SSTR5, SSTR2, SST
40hypertension10.0ADM, POMC
41anorexia nervosa10.0POMC, GH1
42hepatocellular carcinoma10.0PTPN3, SSTR2
43diabetes insipidus10.0POMC
44graves' disease10.0CGA, GNAS
45bronchial endocrine tumor10.0POMC, SST
46schizophrenia10.0ADM, DRD2
47thyroiditis10.0POMC, CGA
48alzheimer's disease10.0SST, DRD2
49amenorrhea10.0POMC, GNRH1
50addison's disease10.0POMC

Graphical network of the top 20 diseases related to Functioning Pituitary Adenoma:



Diseases related to functioning pituitary adenoma

Clinical Features for Functioning Pituitary Adenoma

Drugs & Therapeutics for Functioning Pituitary Adenoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Functioning Pituitary Adenoma

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Genetic Tests for Functioning Pituitary Adenoma

Anatomical Context for Functioning Pituitary Adenoma

Animal Models for Functioning Pituitary Adenoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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Publications for Functioning Pituitary Adenoma

Sources:
51PubMed
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Articles related to Functioning Pituitary Adenoma:

(show top 50)    (show all 77)
idTitleAuthorsYear
1
Peptide receptor radionuclide therapy in a patient with disabling non-functioning pituitary adenoma. (23740146)
2013
2
Combined gangliocytoma and non-functioning pituitary adenoma of the pituitary gland. (22824692)
2012
3
Treatment with octreotide LAR in clinically non-functioning pituitary adenoma: results from a case-control study. (22207350)
2012
4
Co-expression of somatostatin receptor subtypes and estrogen receptor-I+ mRNAs by non-functioning pituitary adenomas in young patients. (20797424)
2011
5
Expression of CRABP1, GRP, and RERG mRNA in clinically non-functioning and functioning pituitary adenomas. (21270509)
2011
6
Can we ever stop imaging in surgically treated and radiotherapy-naive patients with non-functioning pituitary adenoma? (21900406)
2011
7
Pituitary apoplexy in non-functioning pituitary adenomas: long term follow up is important because of significant numbers of tumour recurrences. (21521336)
2011
8
Non-functioning pituitary adenoma and concomitant Rathke's cleft cyst. (21934255)
2011
9
Metabolic, cardiovascular, and cerebrovascular outcomes in growth hormone-deficient subjects with previous cushing's disease or non-functioning pituitary adenoma. (20022992)
2010
10
Apoplexy in non functioning pituitary adenoma after one dose of leuprolide as treatment for prostate cancer. (19842040)
2010
11
A case of secretory (functioning) pituitary macro adenoma:-prolactinoma and acromegaly. (21280433)
2010
12
Asymptomatic non-functioning ectopic pituitary adenoma in the suprasellar region: a case report. (19533468)
2009
13
Comparing progression of non-functioning pituitary adenomas in hypopituitarism patients with and without long-term GH replacement therapy. (19734242)
2009
14
Clinical tumor growth and comparison with proliferation markers in non-functioning (inactive) pituitary adenomas. (18072009)
2008
15
Efficacy of a dopamine-somatostatin chimeric molecule, BIM-23A760, in the control of cell growth from primary cultures of human non-functioning pituitary adenomas: a multi-center study. (18509006)
2008
16
Lymphocytic hypophysitis occurring simultaneously with a functioning pituitary adenoma. (18497455)
2008
17
Medical therapy for clinically non-functioning pituitary adenomas. (18780796)
2008
18
Hypophysitis superimposed on a non-functioning pituitary adenoma: diagnostic clinical, endocrine, and radiologic features. (17923800)
2007
19
Non-functioning pituitary adenoma: immunohistochemical analysis of 85 cases. (17594597)
2007
20
Pasireotide, a multiple somatostatin receptor subtypes ligand, reduces cell viability in non-functioning pituitary adenomas by inhibiting vascular endothelial growth factor secretion. (17395978)
2007
21
The effect of selective sst1, sst2, sst5 somatostatin receptors agonists, a somatostatin/dopamine (SST/DA) chimera and bromocriptine on the "clinically non-functioning" pituitary adenomas in vitro. (16115652)
2006
22
Frequent occurrence of pituitary apoplexy in patients with non-functioning pituitary adenoma. (16487443)
2006
23
Non-functioning pituitary adenoma database: a useful resource to improve the clinical management of pituitary tumors. (17132751)
2006
24
Clinically non-functioning pituitary adenoma. (17082898)
2006
25
Characteristics of adult patients with growth hormone deficiency who underwent neurosurgery for functioning and non-functioning pituitary adenomas and craniopharyngiomas. (15887862)
2005
26
Growth hormone receptor mRNA expression in non-functioning and somatotroph pituitary adenomas: implications for growth hormone substitution therapy? (15891957)
2005
27
Spontaneous remission of functioning pituitary adenomas without hypopituitarism following infarctive apoplexy: two case reports. (15758567)
2005
28
The diaphragma sellae meningioma -- a rare differential diagnosis of non-functioning pituitary adenoma. (15551185)
2004
29
Idiopathic granulomatous hypophysitis presenting as non-functioning pituitary adenoma: description of six cases and review of literature. (15799151)
2004
30
Pharyngeal pituitary non-functioning adenoma with normal intra-sellar gland: massive tumor shrinkage on octreotide therapy. (12611618)
2003
31
A case of non-functioning pituitary adenoma with Cushing's syndrome upon recurrence. (11837535)
2001
32
Metamorphosis of a non-functioning pituitary adenoma to Cushing's disease. (12138984)
2001
33
In vivo secretory potential and the effect of combination therapy with octreotide and cabergoline in patients with clinically non-functioning pituitary adenomas. (11167922)
2001
34
Gene expression of adrenomedullin, leptin, their receptors and neuropeptide Y in hormone-secreting and non-functioning pituitary adenomas, meningiomas and malignant intracranial tumours in humans. (11489141)
2001
35
Long-term treatment with the dopamine agonist quinagolide of patients with clinically non-functioning pituitary adenoma. (11078985)
2000
36
Spontaneous resolution of a non-functioning pituitary adenoma following an apoplexy. (11025642)
2000
37
Hormone levels and tumour size response to quinagolide and cabergoline in patients with prolactin-secreting and clinically non-functioning pituitary adenomas: predictive value of pituitary scintigraphy with 123I-methoxybenzamide. (10762286)
2000
38
Metamorphosis of a non-functioning pituitary adenoma to Cushing's disease. (11141695)
2000
39
Somatostatin and its analog lanreotide inhibit the proliferation of dispersed human non-functioning pituitary adenoma cells in vitro. (10526255)
1999
40
A case of non-functioning pituitary adenoma accompanied by a large cyst. (9638270)
1998
41
Retinoid X receptor gamma mRNA expression is reduced in recurrent non-functioning pituitary adenomas. (9640424)
1998
42
Unique binding pattern to concanavalin A lectin of glycoprotein hormones alpha-subunit hypersecreted by non-functioning pituitary adenomas. (9437241)
1997
43
Glycoprotein hormone alpha-subunit secretion in non-functioning pituitary adenomas]. (9411334)
1997
44
Acute and chronic effects of octreotide on thyroid axis in growth hormone-secreting and clinically non-functioning pituitary adenomas. (7655643)
1995
45
Effect of bromocriptine and SMS 201-995 on growth of human somatotrophic and non-functioning pituitary adenoma cells in vitro. (8124483)
1994
46
Abnormal response of luteinizing hormone beta subunit to thyrotrophin-releasing hormone in patients with non-functioning pituitary adenoma. (7828356)
1994
47
Functioning ectopic supradiaphragmatic pituitary adenomas. (7832831)
1994
48
Octreotide treatment does not affect the size of most non-functioning pituitary adenomas. (8227984)
1993
49
Bromocriptine therapy for non-functioning pituitary adenoma. (2605786)
1989
50
Surgical treatment of functioning pituitary adenoma. (66642)
1976

Genetic Variations for Functioning Pituitary Adenoma

Expression for genes affiliated with Functioning Pituitary Adenoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Functioning Pituitary Adenoma

Search GEO for disease gene expression data for Functioning Pituitary Adenoma.

Pathways for genes affiliated with Functioning Pituitary Adenoma

Sources:
38NCBI BioSystems Database, 54Reactome, 50PharmGKB, 30KEGG, 12EMD Millipore
See all sources

Pathways related to Functioning Pituitary Adenoma according to GeneCards/GeneDecks:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.0DRD2, GNAI2, GNAS
2
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10.0DRD2, GNAI2, GNAS
310.0CGA, GNAI2, GNAS
4
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10.0POMC, CGA, GNRH1
5
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9.9GNAS, GNAI2, SSTR2, SST
6
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9.9GNAS, GNAI2, GPR182, ADM
7
Development Endothelin-1/EDNRA signaling
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9.8GNAS, GNAI2, GNRH1, CGA
8
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9.8POMC, CGA, GNAI2, GNAS
9
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9.5GNAI2, SSTR5, SSTR2, SSTR1, SSTR4, SSTR3
10
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8.2GH1, CGA, DRD2, GNRH1, GNAI2, GNAS
11
Hide members
8.2ADM, GNAS, GNAI2, GNRH1, DRD2, CGA

Compounds for genes affiliated with Functioning Pituitary Adenoma

Sources:
29IUPHAR, 45Novoseek, 11DrugBank, 50PharmGKB, 60Tocris Bioscience, 24HMDB
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Compounds related to Functioning Pituitary Adenoma according to GeneCards/GeneDecks:

(show top 50)    (show all 150)
idCompoundScoreTop Affiliating Genes
1noc-ate2910.3SSTR3, SSTR2, SSTR5
2[111in]dota-noc2910.2SSTR2, SSTR3, SSTR5
3111in-pentetreotide4510.2SSTR2, SST, SSTR1, SSTR5
4bromocriptine29 45 1112.2GNRH1, SST, CGA, POMC
5bim 230502910.2SSTR1, SSTR5, SSTR3
6[111in,90y]dota-lan2910.2SSTR2, SSTR5, SSTR3
7som-2302910.2SSTR3, SSTR2, SSTR5, SSTR1
8[111in,90y]dota-toc2910.1SSTR3, SSTR2, SSTR5
9pasireotide45 1111.1SSTR3, SST, SSTR1, SSTR2, SSTR5
10bim 230302910.1SSTR5, SSTR2, SSTR3
11des-aa5-[d-trp8]srif2910.1SSTR1, SSTR3, SSTR4, SSTR5
12hexarelin45 2911.1CORT, GH1, SST, POMC
13[125i]ltt-srif-282910.1SSTR2, SSTR5, SSTR1, SSTR4, SSTR3
14l-362,8552910.1SSTR5, SSTR2, SSTR1, SSTR4, SSTR3
15vapreotide29 45 1112.1CORT, SSTR2, SST, SSTR3, SSTR5
16bim 236272910.1SSTR3, SSTR4, SSTR1, SSTR5, SSTR2
17srif-142910.1SSTR5, SSTR2, SSTR1, SSTR4, SSTR3
18[125i]tyr10-cst142910.1SSTR5, SSTR2, SSTR4, SSTR3, SSTR1
19[d-tyr8]cyn 1548062910.0SSTR4, SSTR1, SSTR2, SSTR5, SSTR3
20[l-tyr8]cyn 1548062910.0SSTR2, SSTR3, SSTR4, SSTR1, SSTR5
21bim 234542910.0SSTR3, SSTR1, SSTR2, SSTR5, SSTR4
22cabergoline29 45 1112.0CGA, DRD2, GNRH1, SST, GH1
23[125i]cgp 239962910.0SSTR1, SSTR5, SSTR2, SSTR4, SSTR3
24mk-6782910.0SSTR5, SSTR2, SSTR3
25srif-282910.0SSTR3, SSTR1, SSTR4, SSTR2, SSTR5
26ke 1082910.0SSTR5, SSTR1, SSTR4, SSTR3, SSTR2
27cgp 239962910.0SSTR3, SSTR4, SSTR1, SSTR5, SSTR2
28bim 230522910.0SSTR5, SSTR2, SSTR1, SSTR4, SSTR3
29cst-172910.0SSTR5, SSTR2, SSTR1, SSTR4, SSTR3
30cst-142910.0SSTR4, SSTR5, SSTR2, SSTR3, SSTR1
31naloxone45 50 29 1113.0CGA, GNRH1, GH1, SST, POMC
32cyn 154806609.9SSTR5, SSTR3, SST, SSTR4, SSTR1, SSTR2
33cyclosomatostatin609.9SST, SSTR3, SSTR4, SSTR1, SSTR2, SSTR5
34(1r,1s,3r/1r,1r,3s)-l-054,264609.9SSTR5, SSTR3, SST, SSTR4, SSTR1, SSTR2
35nc 4-28b299.9SSTR2, SSTR1, SSTR3
36somatostatin60 2410.9SSTR5, SSTR2, SSTR3, SST, SSTR4, SSTR1
37[111in]dota-noc-ate299.9SSTR5, SSTR2, SSTR3
38dopamine45 29 11 2412.9GNAS, GNRH1, DRD2, SSTR5, SSTR1, SSTR2
39opiate459.9GNRH1, DRD2, CGA, GH1, POMC
40glucose459.7PTPN3, ADM, RXRG, CORT, SSTR2, POMC
41gnrh459.7POMC, CGA, SST, SSTR2, GH1, GNRH1
42epinephrine45 11 2411.7SST, POMC, GH1, CGA, DRD2, GNRH1
43prl-2915299.7SSTR3, SSTR4, SSTR5
44lanreotide45 2910.6PTPN3, SSTR3, SST, SSTR4, SSTR1, SSTR2
45norepinephrine45 11 2411.5DRD2, CGA, GH1, SST, POMC, ADM
46acth459.5POMC, GNAS, GNRH1, GH1, SSTR5, SSTR2
47ribonucleic acid459.4CGA, POMC, SSTR4, GH1, SSTR1, SSTR2
48acetylcholine45 50 29 11 2413.3ADM, GH1, SST, POMC, CGA, PTPN3
49octreotide45 60 29 1111.9POMC, CORT, GNAS, SSTR3, SST, SSTR4
50adenylate458.7SST, ADM, PTPN3, GPR182, SSTR2, GH1

GO Terms for genes affiliated with Functioning Pituitary Adenoma

Sources:
16Gene Ontology
See all sources

Cellular components related to Functioning Pituitary Adenoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral to plasma membraneGO:0058879.5SSTR3, SSTR4, SSTR1, SSTR2, SSTR5, DRD2
2extracellular spaceGO:0056159.2CORT, GNRH1, GH1, SST, POMC, ADM
3extracellular regionGO:0055769.1ADM, GNAS, GNRH1, SCGN, CGA, GH1

Biological processes related to Functioning Pituitary Adenoma according to GeneCards/GeneDecks:

(show all 20)
idNameGO IDScoreTop Affiliating Genes
1somatostatin signaling pathwayGO:03817010.4SSTR5, SSTR3
2hormone-mediated apoptotic signaling pathwayGO:00862810.3SSTR3, SST
3peristalsisGO:03043210.3SSTR2, DRD2
4cellular response to glucocorticoid stimulusGO:07138510.2SSTR3, SSTR4, SSTR2
5positive regulation of multicellular organism growthGO:04001810.2HMGA2, GH1, DRD2
6cellular response to estradiol stimulusGO:07139210.2SSTR3, SSTR1, SSTR2
7adenylate cyclase-inhibiting G-protein coupled receptor signaling pathwayGO:00719310.2CORT, GNAI2, SSTR2
8cerebellum developmentGO:02154910.2SSTR3, SSTR1, SSTR2
9cAMP biosynthetic processGO:00617110.2GNAS, ADM
10positive regulation of receptor internalizationGO:00209210.2GH1, DRD2
11response to nutrientGO:00758410.2GNAI2, SSTR2, SSTR1, SST
12digestionGO:00758610.2SSTR2, SSTR1, SST
13response to starvationGO:04259410.1ADM, SSTR3, SSTR1, SSTR2
14female pregnancyGO:00756510.1ADM, GNRH1, GNAS
15G-protein coupled receptor internalizationGO:00203110.1DRD2, ADM
16forebrain developmentGO:03090010.0SSTR2, SSTR1, SSTR4, SSTR3
17G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGO:0071879.9SSTR5, SSTR2, SSTR1, SSTR4, SSTR3
18G-protein coupled receptor signaling pathwayGO:0071869.6SST, SSTR4, SSTR5, GNAI2
19cell-cell signalingGO:0072679.5GNRH1, CGA, SSTR2, SSTR1, SST, SSTR3
20negative regulation of cell proliferationGO:0082859.4ADM, GNRH1, DRD2, SSTR5, SSTR2, SSTR1

Molecular functions related to Functioning Pituitary Adenoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ionotropic glutamate receptor bindingGO:03525510.1DRD2, GNAS
2G-protein coupled receptor bindingGO:0016649.7POMC, GNAI2, CORT
3somatostatin receptor activityGO:0049949.6SSTR3, SSTR4, SSTR1, SSTR2, SSTR5
4hormone activityGO:0051799.5GNRH1, CGA, GH1, SST, POMC, ADM

Products for genes affiliated with Functioning Pituitary Adenoma

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Sources for Functioning Pituitary Adenoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet