MCID: FNC007
MIFTS: 51

Functioning Pituitary Adenoma malady

Endocrine diseases category

Summaries for Functioning Pituitary Adenoma

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MalaCards: Functioning Pituitary Adenoma, also known as secretory adenoma of the pituitary gland, is related to adenoma and pituitary adenoma. An important gene associated with Functioning Pituitary Adenoma is SSTR5 (somatostatin receptor 5), and among its related pathways are Monoamine GPCRs and Amphetamine addiction. The compounds noc-ate and l-363,301 have been mentioned in the context of this disorder. Affiliated tissues include pituitary, prostate and testes, and related mouse phenotypes are endocrine/exocrine gland and adipose tissue.

Aliases & Classifications for Functioning Pituitary Adenoma

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8Disease Ontology, 60UMLS, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Endocrine diseases


Aliases & Descriptions:

functioning pituitary adenoma 8
secretory adenoma of the pituitary gland 8
pituitary adenoma, functioning 60


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Disease Ontology8 DOID:5395
NCIt39 C8388

Related Diseases for Functioning Pituitary Adenoma

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17GeneCards, 18GeneDecks
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Diseases related to Functioning Pituitary Adenoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 124)
idRelated DiseaseScoreTop Affiliating Genes
1adenoma31.5SSTR3, GNAS, PTPN3, HMGA2, POMC, CGA
2pituitary adenoma31.5GH1, SSTR5, SSTR2, SSTR1, SST, SSTR3
3pituitary apoplexy30.7GNRH1, POMC
4hypopituitarism30.5GH1, GNRH1, SST, POMC, CGA
5meningioma30.4SSTR5, SSTR2, SST
6craniopharyngioma30.4GH1, POMC
7prostate cancer30.3GNAS, SSTR4, SSTR1, SSTR2, SSTR5, GNRH1
8acth-secreting pituitary adenoma30.1GH1, POMC
9acromegaly30.1SST, GH1
10thyroiditis30.1CGA, POMC
11cushing's syndrome30.1POMC, SST, GH1
12adenocarcinoma30.1SSTR1, HMGA2, ADM, SSTR2, SCGN, SST
13hyperprolactinemia30.1SST, GH1, DRD2, CGA, GNRH1, GNAS
14prolactinoma30.1SSTR3, POMC, HMGA2, SST, SSTR4, SSTR1
15functionless pituitary adenoma10.3
16prostatic adenoma10.3
17pituitary cancer10.3
18prostatitis10.3
19non-functioning pituitary adenoma10.3
20acute thyroiditis10.1
21diaphragma sellae meningioma10.1
22growth hormone secreting pituitary adenoma10.1
23gangliocytoma10.1
24cerebrovascular disease10.1
25chordoma10.1
26glucose metabolism disease10.1
27lung adenocarcinoma10.1
28lung adenoma10.1
29mineral metabolism disease10.1
30pituitary infarct10.1
31pancreatitis10.0SST
32osteomalacia10.0GNAS
33diabetic retinopathy10.0ADM
34multiple endocrine neoplasia10.0GNAS
35turner syndrome10.0GNRH1
36endogenous depression10.0POMC
37goiter10.0GNAS
38leukemia10.0HMGA2
39panic disorder10.0POMC
40paraganglioma10.0SST, SSTR2
41rheumatic fever10.0POMC
42hypogonadotropism10.0GNRH1
43drug dependence10.0DRD2
44phaeochromocytoma10.0ADM
45lung cancer10.0POMC, SST
46noonan syndrome10.0PTPN3
47vipoma10.0SST, GH1
48hypertension10.0ADM, POMC
49growth hormone deficiency10.0GH1, POMC
50anorexia nervosa10.0GH1, POMC

Graphical network of the top 20 diseases related to Functioning Pituitary Adenoma:



Diseases related to functioning pituitary adenoma

Clinical Features for Functioning Pituitary Adenoma

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Drugs & Therapeutics for Functioning Pituitary Adenoma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Functioning Pituitary Adenoma

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Anatomical Context for Functioning Pituitary Adenoma

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32MalaCards
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MalaCards organs/tissues related to Functioning Pituitary Adenoma:

32
Pituitary, Prostate, Testes, Bone, Lung, Thyroid, Endothelial

Animal Models for Functioning Pituitary Adenoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Functioning Pituitary Adenoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053799.9CORT, GNAI2, DRD2, SSTR5, HMGA2
2MP:00053759.7HMGA2, POMC, GH1, DRD2, GNAS
3MP:00053709.5GNAS, GNAI2, GNRH1, DRD2, GH1, POMC
4MP:00107719.4GNAS, GNRH1, DRD2, POMC, HMGA2
5MP:00030129.2GNAS, DRD2, SSTR4, SST, SSTR3, POMC
6MP:00053878.9GNAS, GNAI2, GNRH1, DRD2, SSTR4, SST
7MP:00036318.8RXRG, GNAS, GNAI2, GNRH1, DRD2, CGA
8MP:00053868.7CORT, RXRG, GNAS, GNAI2, DRD2, SSTR2
9MP:00053788.6DRD2, GNRH1, GNAI2, GNAS, CORT, CGA
10MP:00053768.3ADM, CORT, GNAS, GNAI2, GNRH1, DRD2

Publications for Functioning Pituitary Adenoma

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50PubMed
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Articles related to Functioning Pituitary Adenoma:

(show top 50)    (show all 120)
idTitleAuthorsYear
1
Self-perception of cognitive function among patients with active acromegaly, controlled acromegaly, and non-functional pituitary adenoma: a pilot study. (24282035)
2013
2
Changes of visual functions in patients with pituitary adenoma. (23893057)
2013
3
Combined gangliocytoma and non-functioning pituitary adenoma of the pituitary gland. (22824692)
2012
4
Co-expression of somatostatin receptor subtypes and estrogen receptor-I+ mRNAs by non-functioning pituitary adenomas in young patients. (20797424)
2011
5
Pituitary apoplexy in non-functioning pituitary adenomas: long term follow up is important because of significant numbers of tumour recurrences. (21521336)
2011
6
Non-functioning pituitary adenoma and concomitant Rathke's cleft cyst. (21934255)
2011
7
Functional impairments caused by chiasma syndromes prior to and following transsphenoidal pituitary adenoma surgery. (20454981)
2010
8
Younger age is a good predictor of better executive function after surgery for pituitary adenoma in adults. (19638252)
2009
9
Beta human chorionic gonadotropin (beta-hCG) expression in pituitary adenomas: relationship to endocrine function and tumour recurrence. (19005764)
2009
10
Asymptomatic non-functioning ectopic pituitary adenoma in the suprasellar region: a case report. (19533468)
2009
11
GH replacement in patients with non-functioning pituitary adenoma (NFA) treated solely by surgery is not associated with increased risk of tumour recurrence. (19236640)
2009
12
Prevalence of gsp oncogene in somatotropinomas and clinically non-functioning pituitary adenomas: our experience. (18642089)
2009
13
Non-functioning pituitary adenomas: clinical feature, laboratorial and imaging assessment, therapeutic management and outcome. (19347183)
2009
14
Efficacy of a dopamine-somatostatin chimeric molecule, BIM-23A760, in the control of cell growth from primary cultures of human non-functioning pituitary adenomas: a multi-center study. (18509006)
2008
15
Effects of selective somatostatin analogs and cortistatin on cell viability in cultured human non-functioning pituitary adenomas. (18276067)
2008
16
Hypophysitis superimposed on a non-functioning pituitary adenoma: diagnostic clinical, endocrine, and radiologic features. (17923800)
2007
17
Non-functioning pituitary adenoma: immunohistochemical analysis of 85 cases. (17594597)
2007
18
Functional magnetic resonance imaging corresponds to Humphrey perimetry in a patient with pituitary adenoma. (16637851)
2006
19
Frequent occurrence of pituitary apoplexy in patients with non-functioning pituitary adenoma. (16487443)
2006
20
Non-functioning pituitary adenomas: clinical features and immunohistochemistry]. (16400431)
2005
21
Characteristics of adult patients with growth hormone deficiency who underwent neurosurgery for functioning and non-functioning pituitary adenomas and craniopharyngiomas. (15887862)
2005
22
Expression and function of sonic hedgehog pathway components in pituitary adenomas: evidence for a direct role in hormone secretion and cell proliferation. (16159933)
2005
23
SIADH closely associated with non-functioning pituitary adenoma. (15351800)
2004
24
Molecular pathology of the pituitary. Development and functional differentiation of pituitary adenomas. (15281338)
2004
25
The diaphragma sellae meningioma -- a rare differential diagnosis of non-functioning pituitary adenoma. (15551185)
2004
26
Pharyngeal pituitary non-functioning adenoma with normal intra-sellar gland: massive tumor shrinkage on octreotide therapy. (12611618)
2003
27
Proteomics and transcriptomics analyses of secretagogin down-regulation in human non-functional pituitary adenomas. (15237930)
2003
28
A case of non-functioning pituitary adenoma with Cushing's syndrome upon recurrence. (11837535)
2001
29
In vivo secretory potential and the effect of combination therapy with octreotide and cabergoline in patients with clinically non-functioning pituitary adenomas. (11167922)
2001
30
Gene expression of adrenomedullin, leptin, their receptors and neuropeptide Y in hormone-secreting and non-functioning pituitary adenomas, meningiomas and malignant intracranial tumours in humans. (11489141)
2001
31
Metamorphosis of a non-functioning pituitary adenoma to Cushing's disease. (11141695)
2000
32
Expression of functional growth hormone secretagogue receptors in human pituitary adenomas: polymerase chain reaction, triple in-situ hybridization and cell culture studies. (10444306)
1999
33
A case of non-functioning pituitary adenoma accompanied by a large cyst. (9638270)
1998
34
A functional thyrotropin- and growth hormone-secreting pituitary adenoma with a ultrastructurally monomorphic feature: a case study. (9700474)
1998
35
Retinoid X receptor gamma mRNA expression is reduced in recurrent non-functioning pituitary adenomas. (9640424)
1998
36
Glycoprotein hormone alpha-subunit secretion in non-functioning pituitary adenomas]. (9411334)
1997
37
The correlation of Ki-67 staining indices with tumour doubling times in regrowing non-functioning pituitary adenomas. (9030353)
1996
38
Effect of surgery on gonadal function of premenopausal women with pituitary adenomas other than prolactinomas. (8793326)
1996
39
Non-functional pituitary chromophobe adenoma in a calf. (8878755)
1996
40
Acute and chronic effects of octreotide on thyroid axis in growth hormone-secreting and clinically non-functioning pituitary adenomas. (7655643)
1995
41
Effects of long-term treatment with the gonadotropin-releasing hormone analog nafarelin in patients with non-functioning pituitary adenomas. (8162161)
1994
42
Effect of bromocriptine and SMS 201-995 on growth of human somatotrophic and non-functioning pituitary adenoma cells in vitro. (8124483)
1994
43
Pituitary adenomas of patients with acromegaly express thyrotropin- releasing hormone receptor messenger RNA: cloning and functional expression of the human thyrotropin-releasing hormone receptor gene. (8396925)
1993
44
A case of sellar chordoma mimicking a non-functioning pituitary adenoma with survival of more than 10 years. (8220788)
1993
45
Equine pituitary adenoma: a functional and morphological study. (8245232)
1993
46
Octreotide treatment does not affect the size of most non-functioning pituitary adenomas. (8227984)
1993
47
Human pituitary corticotroph adenomas in vitro: morphologic and functional responses to corticotropin-releasing hormone and cortisol. (2157992)
1990
48
Pituitary Cushing's disease arising from a previously non-functional corticotrophic chromophobe adenoma. (2985300)
1985
49
Cushing's syndrome presenting the coexistence of a pituitary corticotrophic cell hyperplasia and a unilateral functional adrenal adenoma. (3000119)
1985
50
Surgical treatment of functioning pituitary adenoma. (66642)
1976

Genetic Variations for Functioning Pituitary Adenoma

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Expression for genes affiliated with Functioning Pituitary Adenoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Functioning Pituitary Adenoma

Search GEO for disease gene expression data for Functioning Pituitary Adenoma.

Pathways for genes affiliated with Functioning Pituitary Adenoma

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37NCBI BioSystems Database, 53Reactome, 49PharmGKB, 29KEGG, 12EMD Millipore
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Pathways related to Functioning Pituitary Adenoma according to GeneCards/GeneDecks:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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10.0DRD2, GNAI2, GNAS
2
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10.0DRD2, GNAI2, GNAS
310.0CGA, GNAI2, GNAS
4
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10.0POMC, CGA, GNRH1
5
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9.9GNAS, GNAI2, SSTR2, SST
6
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9.9GNAS, GNAI2, GPR182, ADM
7
Development Endothelin-1/EDNRA signaling
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9.8GNAS, GNAI2, GNRH1, CGA
8
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9.8POMC, CGA, GNAI2, GNAS
9
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9.5GNAI2, SSTR5, SSTR2, SSTR1, SSTR4, SSTR3
10
Hide members
8.2GH1, CGA, DRD2, GNRH1, GNAI2, GNAS
11
Hide members
8.2ADM, GNAS, GNAI2, GNRH1, DRD2, CGA

Compounds for genes affiliated with Functioning Pituitary Adenoma

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28IUPHAR, 44Novoseek, 11DrugBank, 49PharmGKB, 59Tocris Bioscience, 24HMDB
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Compounds related to Functioning Pituitary Adenoma according to GeneCards/GeneDecks:

(show top 50)    (show all 150)
idCompoundScoreTop Affiliating Genes
1noc-ate2810.2SSTR5, SSTR2, SSTR3
2l-363,3012810.2SSTR5, SSTR2, SSTR3
3111in-pentetreotide4410.2SST, SSTR2, SSTR1, SSTR5
4prl-29152810.2SSTR3, SSTR4, SSTR5
5bromocriptine28 44 1112.2GNRH1, CGA, SST, POMC
6som-2302810.2SSTR3, SSTR2, SSTR5, SSTR1
7[111in]dota-noc2810.1SSTR5, SSTR2, SSTR3
8pasireotide44 1111.1SSTR3, SST, SSTR1, SSTR2, SSTR5
9bim 230232810.1SSTR5, SSTR2, SSTR3
10nc 4-28b2810.1SSTR1, SSTR2, SSTR3
11des-aa5-[d-trp8]srif2810.1SSTR3, SSTR4, SSTR5, SSTR1
12hexarelin44 2811.1POMC, GH1, SST, CORT
13[125i]ltt-srif-282810.1SSTR2, SSTR5, SSTR1, SSTR4, SSTR3
14l-362,8552810.1SSTR5, SSTR2, SSTR1, SSTR4, SSTR3
15vapreotide28 44 1112.1CORT, SSTR2, SSTR3, SST, SSTR5
16bim 236272810.1SSTR3, SSTR4, SSTR1, SSTR5, SSTR2
17srif-142810.1SSTR5, SSTR2, SSTR1, SSTR4, SSTR3
18[125i]tyr10-cst142810.1SSTR5, SSTR2, SSTR4, SSTR3, SSTR1
19[d-tyr8]cyn 1548062810.0SSTR4, SSTR1, SSTR2, SSTR5, SSTR3
20[l-tyr8]cyn 1548062810.0SSTR2, SSTR3, SSTR4, SSTR1, SSTR5
21bim 234542810.0SSTR3, SSTR1, SSTR2, SSTR5, SSTR4
22cabergoline28 44 1112.0SST, GH1, CGA, DRD2, GNRH1
23[125i]cgp 239962810.0SSTR1, SSTR5, SSTR2, SSTR4, SSTR3
24[111in]dota-boc-ate2810.0SSTR5, SSTR2, SSTR3
25mk-6782810.0SSTR5, SSTR2, SSTR3
26srif-282810.0SSTR3, SSTR1, SSTR4, SSTR2, SSTR5
27ke 1082810.0SSTR5, SSTR1, SSTR4, SSTR3, SSTR2
28cgp 239962810.0SSTR3, SSTR4, SSTR1, SSTR5, SSTR2
29bim 230522810.0SSTR5, SSTR2, SSTR1, SSTR4, SSTR3
30cst-172810.0SSTR5, SSTR2, SSTR1, SSTR4, SSTR3
31cst-142810.0SSTR4, SSTR5, SSTR2, SSTR3, SSTR1
32naloxone44 49 28 1113.0GNRH1, SST, GH1, POMC, CGA
33cyn 154806599.9SSTR5, SSTR3, SST, SSTR4, SSTR1, SSTR2
34cyclosomatostatin599.9SST, SSTR3, SSTR4, SSTR1, SSTR2, SSTR5
35(1r,1s,3r/1r,1r,3s)-l-054,264599.9SSTR5, SSTR3, SST, SSTR4, SSTR1, SSTR2
36somatostatin59 2410.9SSTR5, SSTR2, SSTR3, SST, SSTR4, SSTR1
37[111in]dota-noc-ate289.9SSTR3, SSTR5, SSTR2
38dopamine44 28 11 2412.9GNRH1, DRD2, GNAS, SSTR5, SSTR2, SSTR1
39opiate449.9GNRH1, DRD2, CGA, GH1, POMC
40bim 23056289.7SSTR5, SSTR2, SSTR3
41glucose449.7RXRG, POMC, CORT, ADM, SSTR2, PTPN3
42gnrh449.7SSTR2, CGA, SST, POMC, GH1, GNAS
43epinephrine44 11 2411.7CGA, SST, POMC, DRD2, GH1, GNRH1
44lanreotide44 2810.6PTPN3, SSTR3, SST, SSTR4, SSTR1, SSTR2
45norepinephrine44 11 2411.5CGA, GH1, SST, ADM, GNRH1, POMC
46acth449.5POMC, GNAS, GNRH1, GH1, SSTR5, SSTR2
47ribonucleic acid449.4CGA, POMC, SSTR4, SSTR1, SSTR2, SSTR5
48acetylcholine44 49 28 11 2413.3PTPN3, DRD2, POMC, SST, GH1, CGA
49octreotide44 59 28 1111.9POMC, CORT, GNAS, SSTR3, SST, SSTR4
50adenylate448.7SST, ADM, PTPN3, GPR182, SSTR2, GH1

GO Terms for genes affiliated with Functioning Pituitary Adenoma

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16Gene Ontology
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Cellular components related to Functioning Pituitary Adenoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral to plasma membraneGO:0058879.5SSTR3, SSTR4, SSTR1, SSTR2, SSTR5, DRD2
2extracellular spaceGO:0056159.2CORT, GNRH1, GH1, SST, POMC, ADM
3extracellular regionGO:0055769.1ADM, GNAS, GNRH1, SCGN, CGA, GH1

Biological processes related to Functioning Pituitary Adenoma according to GeneCards/GeneDecks:

(show all 20)
idNameGO IDScoreTop Affiliating Genes
1somatostatin signaling pathwayGO:03817010.4SSTR5, SSTR3
2hormone-mediated apoptotic signaling pathwayGO:00862810.3SSTR3, SST
3peristalsisGO:03043210.3SSTR2, DRD2
4cellular response to glucocorticoid stimulusGO:07138510.2SSTR3, SSTR4, SSTR2
5positive regulation of multicellular organism growthGO:04001810.2HMGA2, GH1, DRD2
6cellular response to estradiol stimulusGO:07139210.2SSTR3, SSTR1, SSTR2
7adenylate cyclase-inhibiting G-protein coupled receptor signaling pathwayGO:00719310.2CORT, GNAI2, SSTR2
8cerebellum developmentGO:02154910.2SSTR3, SSTR1, SSTR2
9cAMP biosynthetic processGO:00617110.2GNAS, ADM
10positive regulation of receptor internalizationGO:00209210.2GH1, DRD2
11response to nutrientGO:00758410.2GNAI2, SSTR2, SSTR1, SST
12digestionGO:00758610.2SSTR2, SSTR1, SST
13response to starvationGO:04259410.1ADM, SSTR3, SSTR1, SSTR2
14female pregnancyGO:00756510.1ADM, GNRH1, GNAS
15G-protein coupled receptor internalizationGO:00203110.1DRD2, ADM
16forebrain developmentGO:03090010.0SSTR2, SSTR1, SSTR4, SSTR3
17G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGO:0071879.9SSTR5, SSTR2, SSTR1, SSTR4, SSTR3
18G-protein coupled receptor signaling pathwayGO:0071869.6SST, SSTR4, SSTR5, GNAI2
19cell-cell signalingGO:0072679.5GNRH1, CGA, SSTR2, SSTR1, SST, SSTR3
20negative regulation of cell proliferationGO:0082859.4ADM, GNRH1, DRD2, SSTR5, SSTR2, SSTR1

Molecular functions related to Functioning Pituitary Adenoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ionotropic glutamate receptor bindingGO:03525510.1DRD2, GNAS
2G-protein coupled receptor bindingGO:0016649.7POMC, GNAI2, CORT
3somatostatin receptor activityGO:0049949.6SSTR3, SSTR4, SSTR1, SSTR2, SSTR5
4hormone activityGO:0051799.5GNRH1, CGA, GH1, SST, POMC, ADM

Products for genes affiliated with Functioning Pituitary Adenoma

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Sources for Functioning Pituitary Adenoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet