MCID: FNC007
MIFTS: 41

Functioning Pituitary Adenoma malady

Categories: Cancer diseases, Endocrine diseases

Aliases & Classifications for Functioning Pituitary Adenoma

Aliases & Descriptions for Functioning Pituitary Adenoma:

Name: Functioning Pituitary Adenoma 12 14
Secretory Adenoma of the Pituitary Gland 12
Pituitary Adenoma, Functioning 69

Classifications:



External Ids:

Disease Ontology 12 DOID:5395
NCIt 47 C8388
UMLS 69 C0854486

Summaries for Functioning Pituitary Adenoma

MalaCards based summary : Functioning Pituitary Adenoma, also known as secretory adenoma of the pituitary gland, is related to pituitary adenoma, acth-secreting and non-functioning pituitary adenoma. An important gene associated with Functioning Pituitary Adenoma is SST (Somatostatin), and among its related pathways/superpathways are Peptide ligand-binding receptors and Jak-STAT signaling pathway (KEGG). The drugs Hydrocortisone and Prednisone have been mentioned in the context of this disorder. Affiliated tissues include pituitary, prostate and lung, and related phenotypes are homeostasis/metabolism and endocrine/exocrine gland

Related Diseases for Functioning Pituitary Adenoma

Diseases related to Functioning Pituitary Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 131)
id Related Disease Score Top Affiliating Genes
1 pituitary adenoma, acth-secreting 31.5 AIP PRL SST
2 non-functioning pituitary adenoma 12.2
3 functionless pituitary adenoma 11.2
4 pituitary adenoma 10.6
5 adenoma 10.6
6 microtia, hearing impairment, and cleft palate 10.3 GH1 GHR
7 burning mouth syndrome type 3 10.3 POMC SST
8 renal hypoplasia, bilateral 10.3 POMC SST
9 lucey-driscoll syndrome 10.3 MUC1 S100B
10 water-clear cell adenoma 10.3 POMC SST
11 secondary pulmonary hemosiderosis 10.3 MUC1 S100B
12 vaginal adenoma 10.3 POMC SST
13 myelinoclastic diffuse sclerosis 10.2 MUC1 S100B
14 invasive mole 10.2 MUC1 S100B
15 myoma 10.2 MUC1 S100B
16 spleen angiosarcoma 10.2 MUC1 S100B
17 ovarian cystadenoma 10.2 MUC1 S100B
18 macrocephaly, benign familial 10.2 GH1 POMC
19 trombiculiasis 10.2 MUC1 S100B
20 biliary papillomatosis 10.2 MUC1 S100B
21 postgerminal center chronic lymphocytic leukemia/small lymphocytic lymphoma 10.2 MUC1 S100B
22 microinvasive cervical squamous cell carcinoma 10.2 MUC1 S100B
23 corneal intraepithelial neoplasm 10.2 MUC1 S100B
24 grin2a-related speech disorders and epilepsy 10.2 GH1 PRL
25 subglottis verrucous carcinoma 10.2 MUC1 S100B
26 porokeratosis 10.2 MUC1 S100B
27 conjunctival cancer 10.2 MUC1 S100B
28 clear cell ependymoma 10.2 MUC1 S100B
29 behcet's syndrome arthropathy 10.2 MUC1 S100B
30 sternum cancer 10.2 MUC1 S100B
31 endocardium cancer 10.2 MUC1 S100B
32 aneurysm of sinus of valsalva 10.2 MUC1 S100B
33 precursor t-lymphoblastic lymphoma/leukemia 10.2 MUC1 S100B
34 epileptic encephalopathy, early infantile, 24 10.2 GH1 GHR
35 hypogonadism cardiomyopathy 10.2 GH1 POMC
36 rhinoscleroma 10.2 DRD2 PRL
37 cerebral hemisphere lipoma 10.1 GH1 PRL SST
38 anisometropia 10.1 GH1 POMC SST
39 vulvar squamous papilloma 10.1 MUC1 S100B
40 breast secretory carcinoma 10.1 MUC1 POMC SST
41 axial osteomalacia 10.1 GH1 PRL SST
42 mediastinum liposarcoma 10.1 MUC1 S100B
43 wheat allergy 10.1 POMC PRL
44 immune-mediated encephalomyelitis 10.1 PRL S100B
45 pancreatic colloid cystadenoma 10.1 POMC PRL
46 pelvic inflammatory disease 10.1 MUC1 SST
47 pfeiffer rockelein syndrome 10.1 DRD2 PRL
48 pemphigus foliaceus 10.1 MEN1 SST
49 paranasal sinus cancer, adult 10.1 MEN1 SST
50 endometrial mixed adenocarcinoma 10.1 POMC TRH

Graphical network of the top 20 diseases related to Functioning Pituitary Adenoma:



Diseases related to Functioning Pituitary Adenoma

Symptoms & Phenotypes for Functioning Pituitary Adenoma

MGI Mouse Phenotypes related to Functioning Pituitary Adenoma:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.91 AIP DRD2 GHR MEN1 POMC PRL
2 endocrine/exocrine gland MP:0005379 9.87 PRL TRH AIP DRD2 GHR MEN1
3 integument MP:0010771 9.63 AIP DRD2 GHR POMC PRL S100B
4 liver/biliary system MP:0005370 9.43 AIP DRD2 GHR MEN1 POMC PRL
5 neoplasm MP:0002006 9.02 AIP DRD2 MEN1 POMC PRL

Drugs & Therapeutics for Functioning Pituitary Adenoma

Drugs for Functioning Pituitary Adenoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 78)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hydrocortisone Approved, Vet_approved Phase 4 50-23-7 5754 657311
2
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
3
Octreotide Approved, Investigational Phase 4 83150-76-9 383414 6400441
4
lanreotide Approved Phase 4 108736-35-2
5
Somatostatin Approved Phase 4,Phase 2 38916-34-6, 51110-01-1 53481605
6
Butyric Acid Experimental Phase 4 107-92-6 264
7 glucocorticoids Phase 4,Phase 2
8 Cortisol succinate Phase 4
9 Hormone Antagonists Phase 4,Phase 3,Phase 2
10 Anesthetics Phase 4
11 Hormones Phase 4,Phase 3,Phase 2
12 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2
13 Hydrocortisone 17-butyrate 21-propionate Phase 4
14 Hydrocortisone acetate Phase 4
15 Hydrocortisone-17-butyrate Phase 4
16 Anti-Inflammatory Agents Phase 4,Phase 2
17 Antineoplastic Agents, Hormonal Phase 4,Phase 2
18 insulin Phase 4
19 Gastrointestinal Agents Phase 4,Phase 2
20 Angiopeptin Phase 4
21 Insulin, Globin Zinc Phase 4
22 Liver Extracts Phase 4
23
Dopamine Approved Phase 3 51-61-6, 62-31-7 681
24
Cabergoline Approved Phase 3 81409-90-7 54746
25 Dopamine agonists Phase 3
26 Neurotransmitter Agents Phase 3
27 Peripheral Nervous System Agents Phase 3,Phase 2
28 Dopamine Agents Phase 3
29 Protective Agents Phase 3,Phase 2
30 Autonomic Agents Phase 3,Phase 2
31 Antiparkinson Agents Phase 3
32
Prednisolone Approved, Vet_approved Phase 2 50-24-8 5755
33
Methylprednisolone Approved, Vet_approved Phase 2 83-43-2 6741
34
Niacin Approved, Investigational, Nutraceutical Phase 2 59-67-6 938
35
Nicotinamide Approved, Nutraceutical Phase 2 98-92-0 936
36
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
37
Enclomiphene Investigational Phase 2 15690-57-0
38 Clomiphene Phase 2
39 Selective Estrogen Receptor Modulators Phase 2
40 Estrogen Antagonists Phase 2
41 Estrogen Receptor Modulators Phase 2
42 Estrogens Phase 2
43 Zuclomiphene Phase 2
44 Fertility Agents Phase 2
45 Adrenocorticotropic Hormone Phase 2
46 Prednisolone acetate Phase 2
47 Neuroprotective Agents Phase 2
48 Nicotinic Acids Phase 2
49 Trace Elements Phase 2
50 Vitamin B Complex Phase 2

Interventional clinical trials:

(show all 22)
id Name Status NCT ID Phase
1 Effect of Perioperative Glucocorticoid Replacement on Prognosis of Surgical Patients With Sellar Lesions Unknown status NCT02190994 Phase 4
2 Preoperative Octreotide Treatment of Acromegaly Completed NCT00521300 Phase 4
3 Adipokine Profile in Patients With Cushing's Disease on Pasireotide Treatment Completed NCT03080181 Phase 4
4 Octreotide Efficacy and Safety in First-line Acromegalic Patients Completed NCT00171886 Phase 4
5 A Pilot Study of Pre- and Post-operative Use of Somatuline Depot. Completed NCT01861717 Phase 4
6 A Study of the Effects of Pegvisomant on Growth Hormone Excess in McCune-Albright Syndrome Completed NCT00017927 Phase 3
7 Dopamine Agonist Treatment of Non-functioning Pituitary Adenomas Recruiting NCT02288962 Phase 3
8 Clomiphene in Males With Prolactinomas and Persistent Hypogonadism Completed NCT00697814 Phase 2
9 Enhancement of Neurocognitive Functions by Hippocampal Sparing Radiotherapy Recruiting NCT01849484 Phase 2
10 Pasireotide LAR Therapy of Silent Corticotroph Pituitary Tumors Recruiting NCT02749227 Phase 2
11 Targeting Iatrogenic Cushing's Syndrome With 11β-hydroxysteroid Dehydrogenase Type 1 Inhibition Not yet recruiting NCT03111810 Phase 2
12 Temozolomide in Treating Patients With Invasive Pituitary Tumors Withdrawn NCT00601289 Phase 2
13 Impact of Somatostatin Analogs vs. Surgery on Glucose Metabolism in Acromegaly Completed NCT00703079
14 Cognition, Steroids, and Imaging in Cushings Disease Completed NCT00081341
15 Comparison of The Effects of Sevoflurane, Desflurane and Total Intravenous Anaesthesia on Pulmonary Function Tests Recruiting NCT02709863
16 Prospective Study of Clinically Nonfunctioning Pituitary Adenomas Recruiting NCT01556230
17 Evaluation of Patients With Thyroid Disorders Recruiting NCT00001159
18 Heart Rate Variability (HRV) in Pituitary Adenoma Recruiting NCT03164148
19 Utilization of iMRI for Transsphenoidal Resection of Pituitary Macroadenomas Recruiting NCT02396810
20 Rhinological Outcomes in Endonasal Pituitary Surgery Active, not recruiting NCT01504399
21 Genetic and Morphological Analysis of Thyrotoxic Periodic Paralysis Active, not recruiting NCT02287363
22 Adult Growth Hormone Deficiency and Cardiovascular Risk Terminated NCT00720902

Search NIH Clinical Center for Functioning Pituitary Adenoma

Genetic Tests for Functioning Pituitary Adenoma

Anatomical Context for Functioning Pituitary Adenoma

MalaCards organs/tissues related to Functioning Pituitary Adenoma:

39
Pituitary, Prostate, Lung, Testes, Endothelial, Thyroid, Brain

Publications for Functioning Pituitary Adenoma

Articles related to Functioning Pituitary Adenoma:

(show top 50) (show all 96)
id Title Authors Year
1
Increased I^a89catenin and c-myc expression predict aggressive growth of non-functioning pituitary adenomas: An assessment using a tissue microarray-based approach. ( 28260015 )
2017
2
SNPs in the aryl hydrocarbon receptor-interacting protein gene associated with sporadic non-functioning pituitary adenoma. ( 26998050 )
2016
3
Time trends of mortality in patients with non-functioning pituitary adenoma: a Swedish nationwide study. ( 27743172 )
2016
4
Clinical Concerns about Recurrence of Non-Functioning Pituitary Adenoma. ( 27195254 )
2016
5
Relationship of each anterior pituitary hormone deficiency to the size of non-functioning pituitary adenoma in the hospitalized patients. ( 27534814 )
2016
6
Higher Incidence of Morbidity in Women than Men with Non-functioning Pituitary Adenoma: a Swedish Nationwide Study. ( 27147638 )
2016
7
Post-surgical management of non-functioning pituitary adenoma. ( 26116412 )
2015
8
Brain abnormalities on MRI in non-functioning pituitary adenoma patients treated with or without postoperative radiotherapy. ( 25596913 )
2015
9
Biological and radiological exploration and management of non-functioning pituitary adenoma. ( 26122495 )
2015
10
MORTALITY IN PATIENTS WITH NON-FUNCTIONING PITUITARY ADENOMA IS INCREASED: SYSTEMATIC ANALYSIS OF 546 CASES WITH LONG FOLLOW-UP. ( 26546611 )
2015
11
Non-functioning pituitary adenoma: when and how to operate? What pathologic criteria for typing? ( 26070464 )
2015
12
Neuro-ophthalmologic exploration in non-functioning pituitary adenoma. ( 26070465 )
2015
13
Management of clinically non-functioning pituitary adenoma. ( 26072284 )
2015
14
Dopamine 2 and somatostatin 1-5 receptors coexpression in clinically non-functioning pituitary adenomas. ( 25536318 )
2015
15
Hypothalamic-Pituitary Axis in Non-Functioning Pituitary Adenomas: Focus on the Prevalence of Isolated Central Hypoadrenalism. ( 25924873 )
2015
16
Medical management of functioning pituitary adenoma: an update. ( 25446388 )
2014
17
Medical management of functioning pituitary adenoma: an update. ( 26236804 )
2014
18
Cluster headache associated with a clinically non-functioning pituitary adenoma: a case report. ( 25526868 )
2014
19
Candida albicans endophthalmitis in a patient with a non-functioning pituitary adenoma evolving into Cushingx^s disease: A case report. ( 25379398 )
2014
20
Analysis of short- and long-term metabolic effects of growth hormone replacement therapy in adult patients with craniopharyngioma and non-functioning pituitary adenoma. ( 25330765 )
2014
21
Spontaneous regression of non-functioning pituitary adenoma due to pituitary apoplexy following anticoagulation treatment - a case report and review of the literature. ( 23450448 )
2013
22
ZAC1 and SSTR2 are downregulated in non-functioning pituitary adenomas but not in somatotropinomas. ( 24098585 )
2013
23
Peptide receptor radionuclide therapy in a patient with disabling non-functioning pituitary adenoma. ( 23740146 )
2013
24
Self-perception of cognitive function among patients with active acromegaly, controlled acromegaly, and non-functional pituitary adenoma: a pilot study. ( 24282035 )
2013
25
Results of Immunohistochemical staining of cell cycle regulators - the prediction of recurrence of functioning pituitary adenoma. ( 24067736 )
2013
26
Functional Pituitary Adenoma Recurrence after Surgical Resection. ( 24215871 )
2013
27
Intraoperative MRI and endocrinological outcome of transsphenoidal surgery for non-functioning pituitary adenoma. ( 22286656 )
2012
28
Treatment with octreotide LAR in clinically non-functioning pituitary adenoma: results from a case-control study. ( 22207350 )
2012
29
Combined gangliocytoma and non-functioning pituitary adenoma of the pituitary gland. ( 22824692 )
2012
30
Expression of genes FOLR1, BAG1 and LAPTM4B in functioning and non-functioning pituitary adenomas. ( 23023342 )
2012
31
Dopamine 2 receptor expression in various pathological types of clinically non-functioning pituitary adenomas. ( 21597974 )
2012
32
Co-expression of somatostatin receptor subtypes and estrogen receptor-I+ mRNAs by non-functioning pituitary adenomas in young patients. ( 20797424 )
2011
33
Can we ever stop imaging in surgically treated and radiotherapy-naive patients with non-functioning pituitary adenoma? ( 21900406 )
2011
34
Non-functioning pituitary adenoma and concomitant Rathke's cleft cyst. ( 21934255 )
2011
35
Expression of CRABP1, GRP, and RERG mRNA in clinically non-functioning and functioning pituitary adenomas. ( 21270509 )
2011
36
Pituitary apoplexy in non-functioning pituitary adenomas: long term follow up is important because of significant numbers of tumour recurrences. ( 21521336 )
2011
37
Apoplexy in non functioning pituitary adenoma after one dose of leuprolide as treatment for prostate cancer. ( 19842040 )
2010
38
Metabolic, cardiovascular, and cerebrovascular outcomes in growth hormone-deficient subjects with previous cushing's disease or non-functioning pituitary adenoma. ( 20022992 )
2010
39
Prevalence of gsp oncogene in somatotropinomas and clinically non-functioning pituitary adenomas: our experience. ( 18642089 )
2009
40
Comparing progression of non-functioning pituitary adenomas in hypopituitarism patients with and without long-term GH replacement therapy. ( 19734242 )
2009
41
GH replacement in patients with non-functioning pituitary adenoma (NFA) treated solely by surgery is not associated with increased risk of tumour recurrence. ( 19236640 )
2009
42
Non-functioning pituitary adenomas: clinical feature, laboratorial and imaging assessment, therapeutic management and outcome. ( 19347183 )
2009
43
Efficacy of a dopamine-somatostatin chimeric molecule, BIM-23A760, in the control of cell growth from primary cultures of human non-functioning pituitary adenomas: a multi-center study. ( 18509006 )
2008
44
Effects of selective somatostatin analogs and cortistatin on cell viability in cultured human non-functioning pituitary adenomas. ( 18276067 )
2008
45
Medical therapy for clinically non-functioning pituitary adenomas. ( 18780796 )
2008
46
Non-functioning pituitary adenomas infrequently harbor G-protein gene mutations. ( 19169048 )
2008
47
Lymphocytic hypophysitis occurring simultaneously with a functioning pituitary adenoma. ( 18497455 )
2008
48
Hypophysitis superimposed on a non-functioning pituitary adenoma: diagnostic clinical, endocrine, and radiologic features. ( 17923800 )
2007
49
Non-functioning pituitary adenoma: immunohistochemical analysis of 85 cases. ( 17594597 )
2007
50
Pasireotide, a multiple somatostatin receptor subtypes ligand, reduces cell viability in non-functioning pituitary adenomas by inhibiting vascular endothelial growth factor secretion. ( 17395978 )
2007

Variations for Functioning Pituitary Adenoma

Expression for Functioning Pituitary Adenoma

Search GEO for disease gene expression data for Functioning Pituitary Adenoma.

Pathways for Functioning Pituitary Adenoma

GO Terms for Functioning Pituitary Adenoma

Cellular components related to Functioning Pituitary Adenoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.8 GH1 GHR MUC1 POMC S100B SST
2 extracellular region GO:0005576 9.56 GH1 GHR MUC1 POMC PRL S100B
3 secretory granule GO:0030141 9.33 POMC PRL TRH
4 endosome lumen GO:0031904 9.26 GH1 PRL
5 growth hormone receptor complex GO:0070195 8.62 GH1 GHR

Biological processes related to Functioning Pituitary Adenoma according to GeneCards Suite gene sharing:

(show all 13)
id Name GO ID Score Top Affiliating Genes
1 response to hypoxia GO:0001666 9.61 DRD2 MUC1 TRH
2 adult walking behavior GO:0007628 9.52 DRD2 TRH
3 JAK-STAT cascade GO:0007259 9.51 GH1 GHR
4 response to ethanol GO:0045471 9.5 DRD2 PRL TRH
5 response to morphine GO:0043278 9.49 DRD2 GHR
6 hormone-mediated signaling pathway GO:0009755 9.48 GHR TRH
7 regulation of multicellular organism growth GO:0040014 9.46 GHR PRL
8 positive regulation of receptor internalization GO:0002092 9.4 DRD2 GH1
9 positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 9.37 GH1 GHR
10 positive regulation of multicellular organism growth GO:0040018 9.33 DRD2 GH1 GHR
11 growth hormone receptor signaling pathway GO:0060396 9.26 GH1 GHR
12 positive regulation of JAK-STAT cascade GO:0046427 9.13 GH1 GHR PRL
13 JAK-STAT cascade involved in growth hormone signaling pathway GO:0060397 8.8 GH1 GHR PRL

Molecular functions related to Functioning Pituitary Adenoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.02 GH1 POMC PRL SST TRH
2 prolactin receptor binding GO:0005148 8.96 GH1 PRL

Sources for Functioning Pituitary Adenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
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48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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