MCID: FNC007
MIFTS: 36

Functioning Pituitary Adenoma malady

Endocrine diseases category

Summaries for Functioning Pituitary Adenoma

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MalaCards based summary: Functioning Pituitary Adenoma, also known as secretory adenoma of the pituitary gland, is related to adenoma and pituitary adenoma. An important gene associated with Functioning Pituitary Adenoma is SSTR5 (somatostatin receptor 5), and among its related pathways are G alpha (s) signalling events and Neuropeptides signaling through G protein alpha i and G protein alpha q. The compounds [125i]tyr3 sms 201-995 and bim 23060 have been mentioned in the context of this disorder. Affiliated tissues include pituitary, prostate and bone, and related mouse phenotypes are homeostasis/metabolism and behavior/neurological.

Aliases & Classifications for Functioning Pituitary Adenoma

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Functioning Pituitary Adenoma, Aliases & Descriptions:

Name: Functioning Pituitary Adenoma 9
Secretory Adenoma of the Pituitary Gland 9
 
Pituitary Adenoma, Functioning 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Endocrine diseases


External Ids:

Disease Ontology9 DOID:5395
NCIt38 C8388

Related Diseases for Functioning Pituitary Adenoma

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Graphical network of the top 20 diseases related to Functioning Pituitary Adenoma:



Diseases related to functioning pituitary adenoma

Symptoms for Functioning Pituitary Adenoma

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Drugs & Therapeutics for Functioning Pituitary Adenoma

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Drug clinical trials:

Search ClinicalTrials for Functioning Pituitary Adenoma

Search NIH Clinical Center for Functioning Pituitary Adenoma

Genetic Tests for Functioning Pituitary Adenoma

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Anatomical Context for Functioning Pituitary Adenoma

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MalaCards organs/tissues related to Functioning Pituitary Adenoma:

31
Pituitary, Prostate, Bone, Brain, Lung, Thyroid, Testes, Endothelial

Animal Models for Functioning Pituitary Adenoma or affiliated genes

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MGI Mouse Phenotypes related to Functioning Pituitary Adenoma:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053767.6ADM, SSTR5, SST, SSTR2, GNAI2
2MP:00053867.2SSTR2, SST, ADM, RXRG, GNAI2

Publications for Functioning Pituitary Adenoma

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Articles related to Functioning Pituitary Adenoma:

(show top 50)    (show all 78)
idTitleAuthorsYear
1
Medical management of functioning pituitary adenoma: an update. (25446388)
2014
2
Self-perception of cognitive function among patients with active acromegaly, controlled acromegaly, and non-functional pituitary adenoma: a pilot study. (24282035)
2013
3
Results of Immunohistochemical staining of cell cycle regulators - the prediction of recurrence of functioning pituitary adenoma. (24067736)
2013
4
Peptide receptor radionuclide therapy in a patient with disabling non-functioning pituitary adenoma. (23740146)
2013
5
ZAC1 and SSTR2 are downregulated in non-functioning pituitary adenomas but not in somatotropinomas. (24098585)
2013
6
Functional Pituitary Adenoma Recurrence after Surgical Resection. (24215871)
2013
7
Combined gangliocytoma and non-functioning pituitary adenoma of the pituitary gland. (22824692)
2012
8
Intraoperative MRI and endocrinological outcome of transsphenoidal surgery for non-functioning pituitary adenoma. (22286656)
2012
9
Dopamine 2 receptor expression in various pathological types of clinically non-functioning pituitary adenomas. (21597974)
2012
10
Co-expression of somatostatin receptor subtypes and estrogen receptor-I+ mRNAs by non-functioning pituitary adenomas in young patients. (20797424)
2011
11
Expression of CRABP1, GRP, and RERG mRNA in clinically non-functioning and functioning pituitary adenomas. (21270509)
2011
12
Can we ever stop imaging in surgically treated and radiotherapy-naive patients with non-functioning pituitary adenoma? (21900406)
2011
13
Pituitary apoplexy in non-functioning pituitary adenomas: long term follow up is important because of significant numbers of tumour recurrences. (21521336)
2011
14
Metabolic, cardiovascular, and cerebrovascular outcomes in growth hormone-deficient subjects with previous cushing's disease or non-functioning pituitary adenoma. (20022992)
2010
15
Apoplexy in non functioning pituitary adenoma after one dose of leuprolide as treatment for prostate cancer. (19842040)
2010
16
GH replacement in patients with non-functioning pituitary adenoma (NFA) treated solely by surgery is not associated with increased risk of tumour recurrence. (19236640)
2009
17
Comparing progression of non-functioning pituitary adenomas in hypopituitarism patients with and without long-term GH replacement therapy. (19734242)
2009
18
Prevalence of gsp oncogene in somatotropinomas and clinically non-functioning pituitary adenomas: our experience. (18642089)
2009
19
Efficacy of a dopamine-somatostatin chimeric molecule, BIM-23A760, in the control of cell growth from primary cultures of human non-functioning pituitary adenomas: a multi-center study. (18509006)
2008
20
Lymphocytic hypophysitis occurring simultaneously with a functioning pituitary adenoma. (18497455)
2008
21
Medical therapy for clinically non-functioning pituitary adenomas. (18780796)
2008
22
Effects of selective somatostatin analogs and cortistatin on cell viability in cultured human non-functioning pituitary adenomas. (18276067)
2008
23
Hypophysitis superimposed on a non-functioning pituitary adenoma: diagnostic clinical, endocrine, and radiologic features. (17923800)
2007
24
Frequent occurrence of pituitary apoplexy in patients with non-functioning pituitary adenoma. (16487443)
2006
25
Pituitary metastasis masquerading as non-functioning pituitary adenoma in a woman with adenocarcinoma lung. (16832588)
2006
26
Non-functioning pituitary adenoma database: a useful resource to improve the clinical management of pituitary tumors. (17132751)
2006
27
Growth hormone deficiency and replacement in patients with treated Cushing's Disease, prolactinomas and non-functioning pituitary adenomas: effects on body composition, glucose metabolism, lipid status and bone mineral density. (16914933)
2006
28
Non-functioning pituitary adenomas: clinical features and immunohistochemistry]. (16400431)
2005
29
Characteristics of adult patients with growth hormone deficiency who underwent neurosurgery for functioning and non-functioning pituitary adenomas and craniopharyngiomas. (15887862)
2005
30
High-mobility group A2 gene expression is frequently induced in non-functioning pituitary adenomas (NFPAs), even in the absence of chromosome 12 polysomy. (16322327)
2005
31
SIADH closely associated with non-functioning pituitary adenoma. (15351800)
2004
32
Proteomics and transcriptomics analyses of secretagogin down-regulation in human non-functional pituitary adenomas. (15237930)
2003
33
Severe hyponatremia as the presenting feature of clinically non-functional pituitary adenoma with hypopituitarism. (11837807)
2002
34
A case of non-functioning pituitary adenoma with Cushing's syndrome upon recurrence. (11837535)
2001
35
Metamorphosis of a non-functioning pituitary adenoma to Cushing's disease. (12138984)
2001
36
In vivo secretory potential and the effect of combination therapy with octreotide and cabergoline in patients with clinically non-functioning pituitary adenomas. (11167922)
2001
37
Growth promoting effect of human plasma ultrafiltrate bioactive fraction (TBP) for human non-functioning pituitary adenoma cells in vitro. (11194707)
2000
38
Long-term treatment with the dopamine agonist quinagolide of patients with clinically non-functioning pituitary adenoma. (11078985)
2000
39
Spontaneous resolution of a non-functioning pituitary adenoma following an apoplexy. (11025642)
2000
40
Somatostatin and its analog lanreotide inhibit the proliferation of dispersed human non-functioning pituitary adenoma cells in vitro. (10526255)
1999
41
A case of non-functioning pituitary adenoma accompanied by a large cyst. (9638270)
1998
42
Unique binding pattern to concanavalin A lectin of glycoprotein hormones alpha-subunit hypersecreted by non-functioning pituitary adenomas. (9437241)
1997
43
Acute and chronic effects of octreotide on thyroid axis in growth hormone-secreting and clinically non-functioning pituitary adenomas. (7655643)
1995
44
Effects of long-term treatment with the gonadotropin-releasing hormone analog nafarelin in patients with non-functioning pituitary adenomas. (8162161)
1994
45
Effect of bromocriptine and SMS 201-995 on growth of human somatotrophic and non-functioning pituitary adenoma cells in vitro. (8124483)
1994
46
An audit of selected patients with non-functioning pituitary adenoma treated by transsphenoidal surgery without irradiation. (7828355)
1994
47
A case of sellar chordoma mimicking a non-functioning pituitary adenoma with survival of more than 10 years. (8220788)
1993
48
Rapid improvement of visual defects with parenteral depot-bromocriptine in a patient with a non-functioning pituitary adenoma. (2634611)
1989
49
Bromocriptine therapy for non-functioning pituitary adenoma. (2605786)
1989
50
Hypercortisolism due to an autonomously functioning pituitary adenoma: limitations in diagnostic test procedures. (2846626)
1988

Variations for Functioning Pituitary Adenoma

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Expression for genes affiliated with Functioning Pituitary Adenoma

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Search GEO for disease gene expression data for Functioning Pituitary Adenoma.

Pathways for genes affiliated with Functioning Pituitary Adenoma

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Compounds for genes affiliated with Functioning Pituitary Adenoma

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Sources:
28IUPHAR, 43Novoseek, 12DrugBank, 59Tocris Bioscience, 24HMDB
See all sources

Compounds related to Functioning Pituitary Adenoma according to GeneCards Suite gene sharing:

(show top 50)    (show all 64)
idCompoundScoreTop Affiliating Genes
1[125i]tyr3 sms 201-9952810.0SSTR5, SSTR2
2bim 230602810.0SSTR5, SSTR2
3bim 230592810.0SSTR5, SSTR2
4l-363,3012810.0SSTR2, SSTR5
5bim 230562810.0SSTR5, SSTR2
6boc-ate2810.0SSTR5, SSTR2
7[111in,90y]dota-oc2810.0SSTR5, SSTR2
8noc-ate289.9SSTR2, SSTR5
9[111in,90y]dota-lan289.9SSTR2, SSTR5
10[111in,90y]dota-toc289.9SSTR2, SSTR5
11bim 23197289.9SSTR5, SSTR2
12[111in]dota-boc-ate289.9SSTR2, SSTR5
13bim 23023289.9SSTR2, SSTR5
14[111in]dota-noc289.9SSTR2, SSTR5
15[111in]dota-noc-ate289.9SSTR2, SSTR5
16mk-678289.9SSTR2, SSTR5
17bim 23030289.9SSTR2, SSTR5
18[111in,90y]dota-noc289.9SSTR2, SSTR5
19som-230289.9SSTR2, SSTR5
20cgp 23996289.9SSTR5, SSTR2
21ke 108289.9SSTR2, SSTR5
22l-362,855289.9SSTR2, SSTR5
23bim 23627289.8SSTR2, SSTR5
24bim 23454289.8SSTR2, SSTR5
25[l-tyr8]cyn 154806289.8SSTR2, SSTR5
26tyr-3-octreotide439.8SSTR2, SST
27[d-tyr8]cyn 154806289.8SSTR2, SSTR5
28bim 23052289.8SSTR5, SSTR2
29[125i]ltt-srif-28289.8SSTR2, SSTR5
30[125i]tyr10-cst14289.8SSTR2, SSTR5
31srif-14289.7SSTR2, SSTR5
32srif-28289.7SSTR2, SSTR5
33cst-17289.7SSTR2, SSTR5
34[125i]cgp 23996289.7SSTR2, SSTR5
35cst-14289.6SSTR2, SSTR5
36pasireotide43 1210.5SSTR2, SST, SSTR5
37(1r,1s,3r/1r,1r,3s)-l-054,264599.5SSTR5, SST, SSTR2
38cyclosomatostatin599.5SSTR5, SST, SSTR2
39cyn 154806599.5SSTR5, SST, SSTR2
40somatostatin59 2410.5SSTR5, SST, SSTR2
41vapreotide43 28 1211.5SSTR5, SST, SSTR2
42111in-pentetreotide439.5SSTR5, SST, SSTR2
43lanreotide43 2810.5SSTR2, SST, SSTR5
44dtpa439.4SSTR2, SST
45octreotide43 59 28 1212.4SSTR5, SST, SSTR2
46spec-t439.2SSTR2, SST, ADM
47mibg439.2SST, ADM
48glyceraldehyde 3-phosphate438.9ADM, SSTR5, SSTR2
49acth438.8ADM, SSTR5, SST, SSTR2
50glucose438.1SSTR2, SST, ADM, RXRG

GO Terms for genes affiliated with Functioning Pituitary Adenoma

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Biological processes related to Functioning Pituitary Adenoma according to GeneCards Suite gene sharing:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGO:00071879.5SSTR2, SSTR5
2response to starvationGO:00425949.4SSTR2, ADM
3heart developmentGO:00075079.4ADM, RXRG
4digestionGO:00075869.1SSTR2, SST
5adenylate cyclase-inhibiting G-protein coupled receptor signaling pathwayGO:00071939.0GNAI2, SSTR2
6cell-cell signalingGO:00072679.0SSTR2, SST, ADM
7G-protein coupled receptor signaling pathwayGO:00071868.8GNAI2, SSTR5, SST
8response to nutrientGO:00075848.8GNAI2, SST, SSTR2
9negative regulation of cell proliferationGO:00082858.6SSTR2, SST, SSTR5, ADM

Molecular functions related to Functioning Pituitary Adenoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:00051799.3SST, ADM
2somatostatin receptor activityGO:00049949.2SSTR2, SSTR5

Products for genes affiliated with Functioning Pituitary Adenoma

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Sources for Functioning Pituitary Adenoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet