MCID: FNC007
MIFTS: 51

Functioning Pituitary Adenoma malady

Endocrine diseases category

Summaries for Functioning Pituitary Adenoma

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MalaCards: Functioning Pituitary Adenoma, also known as secretory adenoma of the pituitary gland, is related to adenoma and pituitary adenoma. An important gene associated with Functioning Pituitary Adenoma is SSTR5 (somatostatin receptor 5), and among its related pathways are Monoamine GPCRs and Amphetamine addiction. The compounds noc-ate and mk-678 have been mentioned in the context of this disorder. Affiliated tissues include pituitary, testes and prostate, and related mouse phenotypes are endocrine/exocrine gland and adipose tissue.

Aliases & Classifications for Functioning Pituitary Adenoma

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8Disease Ontology, 60UMLS, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Endocrine diseases


Aliases & Descriptions:

functioning pituitary adenoma 8
secretory adenoma of the pituitary gland 8
pituitary adenoma, functioning 60


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Disease Ontology8 DOID:5395
NCIt39 C8388

Related Diseases for Functioning Pituitary Adenoma

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17GeneCards, 18GeneDecks
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Diseases related to Functioning Pituitary Adenoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 124)
idRelated DiseaseScoreTop Affiliating Genes
1adenoma31.5SSTR3, GNAS, PTPN3, HMGA2, POMC, CGA
2pituitary adenoma31.5GH1, SSTR5, SSTR2, SSTR1, SST, SSTR3
3pituitary apoplexy30.7GNRH1, POMC
4hypopituitarism30.5GH1, GNRH1, SST, POMC, CGA
5meningioma30.4SSTR5, SSTR2, SST
6craniopharyngioma30.4GH1, POMC
7prostate cancer30.3GNAS, SSTR4, SSTR1, SSTR2, SSTR5, GNRH1
8acth-secreting pituitary adenoma30.1GH1, POMC
9acromegaly30.1SST, GH1
10thyroiditis30.1CGA, POMC
11cushing's syndrome30.1POMC, SST, GH1
12adenocarcinoma30.1SSTR1, HMGA2, ADM, SSTR2, SCGN, SST
13hyperprolactinemia30.1SST, GH1, DRD2, CGA, GNRH1, GNAS
14prolactinoma30.1SSTR3, POMC, HMGA2, SST, SSTR4, SSTR1
15functionless pituitary adenoma10.3
16prostatic adenoma10.3
17pituitary cancer10.3
18prostatitis10.3
19non-functioning pituitary adenoma10.3
20acute thyroiditis10.1
21diaphragma sellae meningioma10.1
22growth hormone secreting pituitary adenoma10.1
23gangliocytoma10.1
24cerebrovascular disease10.1
25chordoma10.1
26glucose metabolism disease10.1
27lung adenocarcinoma10.1
28lung adenoma10.1
29mineral metabolism disease10.1
30pituitary infarct10.1
31pancreatitis10.0SST
32osteomalacia10.0GNAS
33diabetic retinopathy10.0ADM
34multiple endocrine neoplasia10.0GNAS
35turner syndrome10.0GNRH1
36endogenous depression10.0POMC
37goiter10.0GNAS
38leukemia10.0HMGA2
39panic disorder10.0POMC
40paraganglioma10.0SST, SSTR2
41rheumatic fever10.0POMC
42hypogonadotropism10.0GNRH1
43drug dependence10.0DRD2
44phaeochromocytoma10.0ADM
45lung cancer10.0POMC, SST
46noonan syndrome10.0PTPN3
47vipoma10.0SST, GH1
48hypertension10.0ADM, POMC
49growth hormone deficiency10.0GH1, POMC
50anorexia nervosa10.0GH1, POMC

Graphical network of the top 20 diseases related to Functioning Pituitary Adenoma:



Diseases related to functioning pituitary adenoma

Clinical Features for Functioning Pituitary Adenoma

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Drugs & Therapeutics for Functioning Pituitary Adenoma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Functioning Pituitary Adenoma

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Anatomical Context for Functioning Pituitary Adenoma

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32MalaCards
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MalaCards organs/tissues related to Functioning Pituitary Adenoma:

32
Pituitary, Testes, Prostate, Bone, Lung, Thyroid, Endothelial

Animal Models for Functioning Pituitary Adenoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Functioning Pituitary Adenoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053799.9CORT, GNAI2, DRD2, SSTR5, HMGA2
2MP:00053759.7HMGA2, POMC, GH1, DRD2, GNAS
3MP:00053709.5GNAS, GNAI2, GNRH1, DRD2, GH1, POMC
4MP:00107719.4GNAS, GNRH1, DRD2, POMC, HMGA2
5MP:00030129.2GNAS, DRD2, SSTR4, SST, SSTR3, POMC
6MP:00053878.9GNAS, GNAI2, GNRH1, DRD2, SSTR4, SST
7MP:00036318.8RXRG, GNAS, GNAI2, GNRH1, DRD2, CGA
8MP:00053868.7CORT, RXRG, GNAS, GNAI2, DRD2, SSTR2
9MP:00053788.6DRD2, GNRH1, GNAI2, GNAS, CORT, CGA
10MP:00053768.3ADM, CORT, GNAS, GNAI2, GNRH1, DRD2

Publications for Functioning Pituitary Adenoma

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50PubMed
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Articles related to Functioning Pituitary Adenoma:

(show top 50)    (show all 120)
idTitleAuthorsYear
1
Results of Immunohistochemical staining of cell cycle regulators - the prediction of recurrence of functioning pituitary adenoma. (24067736)
2013
2
Functional Pituitary Adenoma Recurrence after Surgical Resection. (24215871)
2013
3
Spontaneous regression of non-functioning pituitary adenoma due to pituitary apoplexy following anticoagulation treatment - a case report and review of the literature. (23450448)
2013
4
Intraoperative MRI and endocrinological outcome of transsphenoidal surgery for non-functioning pituitary adenoma. (22286656)
2012
5
Dopamine 2 receptor expression in various pathological types of clinically non-functioning pituitary adenomas. (21597974)
2012
6
Treatment with octreotide LAR in clinically non-functioning pituitary adenoma: results from a case-control study. (22207350)
2012
7
Impact of intraoperative MRI-guided transsphenoidal surgery on endocrine function and hormone substitution therapy in patients with pituitary adenoma. (23135765)
2012
8
Surgical outcome of the endoscopic endonasal approach for non-functioning giant pituitary adenoma. (20851609)
2011
9
Expression of CRABP1, GRP, and RERG mRNA in clinically non-functioning and functioning pituitary adenomas. (21270509)
2011
10
Can we ever stop imaging in surgically treated and radiotherapy-naive patients with non-functioning pituitary adenoma? (21900406)
2011
11
Expression of functional KISS1 and KISS1R system is altered in human pituitary adenomas: evidence for apoptotic action of kisspeptin-10. (21169415)
2011
12
Apoplexy in non functioning pituitary adenoma after one dose of leuprolide as treatment for prostate cancer. (19842040)
2010
13
Lymphocytic hypophysitis with normal pituitary function mimicking a pituitary adenoma: a case report and review of literature. (20040330)
2010
14
Asymptomatic non-functioning ectopic pituitary adenoma in the suprasellar region: a case report. (19533468)
2009
15
Clinical tumor growth and comparison with proliferation markers in non-functioning (inactive) pituitary adenomas. (18072009)
2008
16
Medical therapy for clinically non-functioning pituitary adenomas. (18780796)
2008
17
Non-functioning pituitary adenomas infrequently harbor G-protein gene mutations. (19169048)
2008
18
Nonfunctioning pituitary adenoma: incidence, causes of death and quality of life in relation to pituitary function. (17356906)
2007
19
Apoplexy accompanying pituitary adenoma as a complication of preoperative anterior pituitary function tests. (17468811)
2007
20
Immediate postoperative radiotherapy in residual nonfunctioning pituitary adenoma: beneficial effect on local control without additional negative impact on pituitary function and life expectancy. (17197121)
2007
21
Quantitative analysis of somatostatin receptor subtype (SSTR1-5) gene expression levels in somatotropinomas and non-functioning pituitary adenomas. (17218727)
2007
22
Familial pituitary adenomas with a heterogeneous functional pattern: clinical and genetic features. (17993773)
2007
23
Pasireotide, a multiple somatostatin receptor subtypes ligand, reduces cell viability in non-functioning pituitary adenomas by inhibiting vascular endothelial growth factor secretion. (17395978)
2007
24
Pituitary metastasis masquerading as non-functioning pituitary adenoma in a woman with adenocarcinoma lung. (16832588)
2006
25
Non-functioning pituitary adenoma database: a useful resource to improve the clinical management of pituitary tumors. (17132751)
2006
26
Growth hormone deficiency and replacement in patients with treated Cushing's Disease, prolactinomas and non-functioning pituitary adenomas: effects on body composition, glucose metabolism, lipid status and bone mineral density. (16914933)
2006
27
Presentation of a functional pituitary adenoma as a significant decrease in prostate-specific antigen level in a patient followed for prostate cancer. (17187699)
2006
28
Intrasellar plasmacytoma presenting as a non-functional invasive pituitary macro-adenoma: case report & literature review. (16703411)
2006
29
Growth hormone receptor mRNA expression in non-functioning and somatotroph pituitary adenomas: implications for growth hormone substitution therapy? (15891957)
2005
30
SIADH closely associated with non-functioning pituitary adenoma. (15351800)
2004
31
Idiopathic granulomatous hypophysitis presenting as non-functioning pituitary adenoma: description of six cases and review of literature. (15799151)
2004
32
Functional in vitro studies on the role and regulation of interleukin-6 in human somatotroph pituitary adenomas. (14585094)
2003
33
Expression of Pit-1 and growth hormone-releasing hormone receptor mRNA in human pituitary adenomas: difference among functioning, silent, and other nonfunctioning adenomas. (12165656)
2002
34
Metamorphosis of a non-functioning pituitary adenoma to Cushing's disease. (12138984)
2001
35
Genetic heterogeneity and alterations in chromosome 9 loci in a localized region of a functional pituitary adenoma. (11297766)
2001
36
Growth promoting effect of human plasma ultrafiltrate bioactive fraction (TBP) for human non-functioning pituitary adenoma cells in vitro. (11194707)
2000
37
Functional significance of prop-1 gene expression in pituitary adenomas. (10890192)
2000
38
Spontaneous resolution of a non-functioning pituitary adenoma following an apoplexy. (11025642)
2000
39
Somatostatin and its analog lanreotide inhibit the proliferation of dispersed human non-functioning pituitary adenoma cells in vitro. (10526255)
1999
40
Structure-function correlations of growth hormone or/and prolactin-producing pituitary adenomas: an in vitro study with the reverse hemolytic plaque assay. (10595830)
1999
41
Unique binding pattern to concanavalin A lectin of glycoprotein hormones alpha-subunit hypersecreted by non-functioning pituitary adenomas. (9437241)
1997
42
Somatostatin receptor imaging in somatotroph and non-functioning pituitary adenomas: correlation with hormonal and visual responses to octreotide. (9425399)
1997
43
Effect of bromocriptine and SMS 201-995 on growth of human somatotrophic and non-functioning pituitary adenoma cells in vitro. (8124483)
1994
44
Growth hormone-prolactin-thyrotropin-secreting pituitary adenoma in atypical McCune-Albright syndrome with functionally normal Gs alpha protein. (7962285)
1994
45
An audit of selected patients with non-functioning pituitary adenoma treated by transsphenoidal surgery without irradiation. (7828355)
1994
46
Recovery of visual and endocrine function following transsphenoidal surgery of large nonfunctioning pituitary adenomas. (7868814)
1994
47
Functioning ectopic supradiaphragmatic pituitary adenomas. (7832831)
1994
48
Rapid improvement of visual defects with parenteral depot-bromocriptine in a patient with a non-functioning pituitary adenoma. (2634611)
1989
49
Hypercortisolism due to an autonomously functioning pituitary adenoma: limitations in diagnostic test procedures. (2846626)
1988
50
Functional pituitary acidophil adenoma in a cat with diabetes mellitus and acromegalic features. (3018986)
1986

Genetic Variations for Functioning Pituitary Adenoma

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Expression for genes affiliated with Functioning Pituitary Adenoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Functioning Pituitary Adenoma

Search GEO for disease gene expression data for Functioning Pituitary Adenoma.

Pathways for genes affiliated with Functioning Pituitary Adenoma

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37NCBI BioSystems Database, 53Reactome, 49PharmGKB, 29KEGG, 12EMD Millipore
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Pathways related to Functioning Pituitary Adenoma according to GeneCards/GeneDecks:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.0DRD2, GNAI2, GNAS
2
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10.0DRD2, GNAI2, GNAS
310.0CGA, GNAI2, GNAS
4
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10.0POMC, CGA, GNRH1
5
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9.9GNAS, GNAI2, SSTR2, SST
6
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9.9GNAS, GNAI2, GPR182, ADM
7
Development Endothelin-1/EDNRA signaling
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9.8GNAS, GNAI2, GNRH1, CGA
8
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9.8POMC, CGA, GNAI2, GNAS
9
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9.5GNAI2, SSTR5, SSTR2, SSTR1, SSTR4, SSTR3
10
Hide members
8.2GH1, CGA, DRD2, GNRH1, GNAI2, GNAS
11
Hide members
8.2ADM, GNAS, GNAI2, GNRH1, DRD2, CGA

Compounds for genes affiliated with Functioning Pituitary Adenoma

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28IUPHAR, 44Novoseek, 11DrugBank, 49PharmGKB, 59Tocris Bioscience, 24HMDB
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Compounds related to Functioning Pituitary Adenoma according to GeneCards/GeneDecks:

(show top 50)    (show all 150)
idCompoundScoreTop Affiliating Genes
1noc-ate2810.3SSTR2, SSTR3, SSTR5
2mk-6782810.2SSTR2, SSTR5, SSTR3
3[111in,90y]dota-lan2810.2SSTR2, SSTR3, SSTR5
4111in-pentetreotide4410.2SSTR5, SSTR2, SSTR1, SST
5bromocriptine28 44 1112.2GNRH1, SST, POMC, CGA
6bim 231972810.2SSTR3, SSTR2, SSTR5
7bim 230682810.2SSTR4, SSTR2, SSTR3
8som-2302810.2SSTR3, SSTR1, SSTR2, SSTR5
9[111in,90y]dota-toc2810.1SSTR3, SSTR2, SSTR5
10pasireotide44 1111.1SSTR2, SSTR1, SST, SSTR3, SSTR5
11[111in]dota-noc-ate2810.1SSTR3, SSTR2, SSTR5
12des-aa5-[d-trp8]srif2810.1SSTR3, SSTR5, SSTR1, SSTR4
13hexarelin44 2811.1POMC, SST, GH1, CORT
14bim 236272810.1SSTR2, SSTR5, SSTR1, SSTR4, SSTR3
15[125i]tyr10-cst142810.1SSTR3, SSTR4, SSTR1, SSTR2, SSTR5
16vapreotide28 44 1112.1SSTR5, SSTR2, SST, SSTR3, CORT
17[125i]ltt-srif-282810.1SSTR5, SSTR2, SSTR3, SSTR4, SSTR1
18l-362,8552810.1SSTR5, SSTR2, SSTR1, SSTR4, SSTR3
19bim 234542810.1SSTR3, SSTR1, SSTR5, SSTR4, SSTR2
20[l-tyr8]cyn 1548062810.0SSTR2, SSTR5, SSTR1, SSTR4, SSTR3
21[d-tyr8]cyn 1548062810.0SSTR5, SSTR2, SSTR1, SSTR4, SSTR3
22bim 230522810.0SSTR2, SSTR3, SSTR4, SSTR1, SSTR5
23cabergoline28 44 1112.0CGA, DRD2, GNRH1, GH1, SST
24cst-172810.0SSTR4, SSTR3, SSTR1, SSTR2, SSTR5
25[111in,90y]dota-noc2810.0SSTR2, SSTR5, SSTR3
26bim 230302810.0SSTR5, SSTR3, SSTR2
27[125i]cgp 239962810.0SSTR5, SSTR2, SSTR1, SSTR4, SSTR3
28cgp 239962810.0SSTR3, SSTR4, SSTR1, SSTR2, SSTR5
29ke 1082810.0SSTR3, SSTR4, SSTR1, SSTR5, SSTR2
30srif-142810.0SSTR3, SSTR4, SSTR1, SSTR2, SSTR5
31srif-282810.0SSTR3, SSTR4, SSTR1, SSTR2, SSTR5
32cst-142810.0SSTR5, SSTR2, SSTR1, SSTR4, SSTR3
33naloxone44 49 28 1113.0CGA, POMC, SST, GH1, GNRH1
34cyclosomatostatin599.9SSTR2, SSTR5, SSTR3, SST, SSTR1, SSTR4
35(1r,1s,3r/1r,1r,3s)-l-054,264599.9SSTR5, SSTR2, SSTR1, SSTR4, SST, SSTR3
36cyn 154806599.9SSTR5, SSTR2, SSTR1, SSTR3, SST, SSTR4
37somatostatin59 2410.9SSTR3, SST, SSTR4, SSTR1, SSTR2, SSTR5
38dopamine44 28 11 2412.9SSTR1, GNAS, GNRH1, DRD2, SSTR5, SSTR2
39bim 23050289.8SSTR5, SSTR1, SSTR3
40[111in,90y]dota-oc289.7SSTR3, SSTR2, SSTR5
41glucose449.7SSTR2, PTPN3, POMC, CORT, ADM, RXRG
42gnrh449.7SST, GH1, SSTR2, CGA, GNRH1, GNAS
43epinephrine44 11 2411.7ADM, GNRH1, SST, DRD2, CGA, GH1
44lanreotide44 2810.6PTPN3, SSTR3, SST, SSTR4, SSTR1, SSTR2
45norepinephrine44 11 2411.5GNAS, CGA, GNRH1, DRD2, GH1, SST
46acth449.5SSTR5, CORT, GH1, SSTR2, SST, GNRH1
47ribonucleic acid449.4GNRH1, SSTR4, SSTR1, SSTR2, GNAS, POMC
48acetylcholine44 49 28 11 2413.3SST, GH1, CGA, DRD2, GNRH1, ADM
49octreotide44 59 28 1111.9POMC, CORT, GNAS, SSTR3, SST, SSTR4
50adenylate448.7SSTR2, SST, POMC, SSTR1, ADM, PTPN3

GO Terms for genes affiliated with Functioning Pituitary Adenoma

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16Gene Ontology
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Cellular components related to Functioning Pituitary Adenoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral to plasma membraneGO:0058879.5SSTR3, SSTR4, SSTR1, SSTR2, SSTR5, DRD2
2extracellular spaceGO:0056159.2CORT, GNRH1, GH1, SST, POMC, ADM
3extracellular regionGO:0055769.1ADM, GNAS, GNRH1, SCGN, CGA, GH1

Biological processes related to Functioning Pituitary Adenoma according to GeneCards/GeneDecks:

(show all 20)
idNameGO IDScoreTop Affiliating Genes
1somatostatin signaling pathwayGO:03817010.4SSTR5, SSTR3
2hormone-mediated apoptotic signaling pathwayGO:00862810.3SSTR3, SST
3peristalsisGO:03043210.3SSTR2, DRD2
4cellular response to glucocorticoid stimulusGO:07138510.2SSTR3, SSTR4, SSTR2
5positive regulation of multicellular organism growthGO:04001810.2HMGA2, GH1, DRD2
6cellular response to estradiol stimulusGO:07139210.2SSTR3, SSTR1, SSTR2
7adenylate cyclase-inhibiting G-protein coupled receptor signaling pathwayGO:00719310.2CORT, GNAI2, SSTR2
8cerebellum developmentGO:02154910.2SSTR3, SSTR1, SSTR2
9cAMP biosynthetic processGO:00617110.2GNAS, ADM
10positive regulation of receptor internalizationGO:00209210.2GH1, DRD2
11response to nutrientGO:00758410.2GNAI2, SSTR2, SSTR1, SST
12digestionGO:00758610.2SSTR2, SSTR1, SST
13response to starvationGO:04259410.1ADM, SSTR3, SSTR1, SSTR2
14female pregnancyGO:00756510.1ADM, GNRH1, GNAS
15G-protein coupled receptor internalizationGO:00203110.1DRD2, ADM
16forebrain developmentGO:03090010.0SSTR2, SSTR1, SSTR4, SSTR3
17G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGO:0071879.9SSTR5, SSTR2, SSTR1, SSTR4, SSTR3
18G-protein coupled receptor signaling pathwayGO:0071869.6SST, SSTR4, SSTR5, GNAI2
19cell-cell signalingGO:0072679.5GNRH1, CGA, SSTR2, SSTR1, SST, SSTR3
20negative regulation of cell proliferationGO:0082859.4ADM, GNRH1, DRD2, SSTR5, SSTR2, SSTR1

Molecular functions related to Functioning Pituitary Adenoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ionotropic glutamate receptor bindingGO:03525510.1DRD2, GNAS
2G-protein coupled receptor bindingGO:0016649.7POMC, GNAI2, CORT
3somatostatin receptor activityGO:0049949.6SSTR3, SSTR4, SSTR1, SSTR2, SSTR5
4hormone activityGO:0051799.5GNRH1, CGA, GH1, SST, POMC, ADM

Products for genes affiliated with Functioning Pituitary Adenoma

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Sources for Functioning Pituitary Adenoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet