MCID: FNC007
MIFTS: 43

Functioning Pituitary Adenoma malady

Cancer diseases, Endocrine diseases categories

Summaries for Functioning Pituitary Adenoma

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34MalaCards
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MalaCards: Functioning Pituitary Adenoma, also known as secretory adenoma of the pituitary gland, is related to adenoma and pituitary adenoma. An important gene associated with Functioning Pituitary Adenoma is SSTR5 (somatostatin receptor 5), and among its related pathways are G alpha (s) signalling events and Neuropeptides signaling through G protein alpha i and G protein alpha q. The compounds [125i]tyr3 sms 201-995 and bim 23060 have been mentioned in the context of this disorder. Affiliated tissues include pituitary, prostate and bone, and related mouse phenotypes are homeostasis/metabolism and behavior/neurological.

Aliases & Classifications for Functioning Pituitary Adenoma

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9Disease Ontology, 63UMLS, 41NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Endocrine diseases


Aliases & Descriptions:

functioning pituitary adenoma 9
secretory adenoma of the pituitary gland 9
pituitary adenoma, functioning 63


External Ids:

Disease Ontology9 DOID:5395
NCIt41 C8388

Related Diseases for Functioning Pituitary Adenoma

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18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Functioning Pituitary Adenoma:



Diseases related to functioning pituitary adenoma

Symptoms for Functioning Pituitary Adenoma

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Drugs & Therapeutics for Functioning Pituitary Adenoma

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Functioning Pituitary Adenoma

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Genetic Tests for Functioning Pituitary Adenoma

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Anatomical Context for Functioning Pituitary Adenoma

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34MalaCards
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MalaCards organs/tissues related to Functioning Pituitary Adenoma:

34
Pituitary, Prostate, Bone, Lung, Testes, Thyroid, Endothelial

Animal Models for Functioning Pituitary Adenoma or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Functioning Pituitary Adenoma:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053767.6ADM, SSTR5, SST, SSTR2, GNAI2
2MP:00053867.2SSTR2, SST, ADM, RXRG, GNAI2

Publications for Functioning Pituitary Adenoma

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53PubMed
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Articles related to Functioning Pituitary Adenoma:

(show top 50)    (show all 73)
idTitleAuthorsYear
1
Self-perception of cognitive function among patients with active acromegaly, controlled acromegaly, and non-functional pituitary adenoma: a pilot study. (24282035)
2013
2
Results of Immunohistochemical staining of cell cycle regulators - the prediction of recurrence of functioning pituitary adenoma. (24067736)
2013
3
Peptide receptor radionuclide therapy in a patient with disabling non-functioning pituitary adenoma. (23740146)
2013
4
Functional Pituitary Adenoma Recurrence after Surgical Resection. (24215871)
2013
5
Combined gangliocytoma and non-functioning pituitary adenoma of the pituitary gland. (22824692)
2012
6
Intraoperative MRI and endocrinological outcome of transsphenoidal surgery for non-functioning pituitary adenoma. (22286656)
2012
7
Dopamine 2 receptor expression in various pathological types of clinically non-functioning pituitary adenomas. (21597974)
2012
8
Treatment with octreotide LAR in clinically non-functioning pituitary adenoma: results from a case-control study. (22207350)
2012
9
Co-expression of somatostatin receptor subtypes and estrogen receptor-I+ mRNAs by non-functioning pituitary adenomas in young patients. (20797424)
2011
10
Expression of CRABP1, GRP, and RERG mRNA in clinically non-functioning and functioning pituitary adenomas. (21270509)
2011
11
Can we ever stop imaging in surgically treated and radiotherapy-naive patients with non-functioning pituitary adenoma? (21900406)
2011
12
Pituitary apoplexy in non-functioning pituitary adenomas: long term follow up is important because of significant numbers of tumour recurrences. (21521336)
2011
13
Metabolic, cardiovascular, and cerebrovascular outcomes in growth hormone-deficient subjects with previous cushing's disease or non-functioning pituitary adenoma. (20022992)
2010
14
Apoplexy in non functioning pituitary adenoma after one dose of leuprolide as treatment for prostate cancer. (19842040)
2010
15
GH replacement in patients with non-functioning pituitary adenoma (NFA) treated solely by surgery is not associated with increased risk of tumour recurrence. (19236640)
2009
16
Comparing progression of non-functioning pituitary adenomas in hypopituitarism patients with and without long-term GH replacement therapy. (19734242)
2009
17
Prevalence of gsp oncogene in somatotropinomas and clinically non-functioning pituitary adenomas: our experience. (18642089)
2009
18
Efficacy of a dopamine-somatostatin chimeric molecule, BIM-23A760, in the control of cell growth from primary cultures of human non-functioning pituitary adenomas: a multi-center study. (18509006)
2008
19
Lymphocytic hypophysitis occurring simultaneously with a functioning pituitary adenoma. (18497455)
2008
20
Medical therapy for clinically non-functioning pituitary adenomas. (18780796)
2008
21
Effects of selective somatostatin analogs and cortistatin on cell viability in cultured human non-functioning pituitary adenomas. (18276067)
2008
22
Hypophysitis superimposed on a non-functioning pituitary adenoma: diagnostic clinical, endocrine, and radiologic features. (17923800)
2007
23
Frequent occurrence of pituitary apoplexy in patients with non-functioning pituitary adenoma. (16487443)
2006
24
Pituitary metastasis masquerading as non-functioning pituitary adenoma in a woman with adenocarcinoma lung. (16832588)
2006
25
Non-functioning pituitary adenoma database: a useful resource to improve the clinical management of pituitary tumors. (17132751)
2006
26
Growth hormone deficiency and replacement in patients with treated Cushing's Disease, prolactinomas and non-functioning pituitary adenomas: effects on body composition, glucose metabolism, lipid status and bone mineral density. (16914933)
2006
27
Non-functioning pituitary adenomas: clinical features and immunohistochemistry]. (16400431)
2005
28
Characteristics of adult patients with growth hormone deficiency who underwent neurosurgery for functioning and non-functioning pituitary adenomas and craniopharyngiomas. (15887862)
2005
29
High-mobility group A2 gene expression is frequently induced in non-functioning pituitary adenomas (NFPAs), even in the absence of chromosome 12 polysomy. (16322327)
2005
30
SIADH closely associated with non-functioning pituitary adenoma. (15351800)
2004
31
Proteomics and transcriptomics analyses of secretagogin down-regulation in human non-functional pituitary adenomas. (15237930)
2003
32
Severe hyponatremia as the presenting feature of clinically non-functional pituitary adenoma with hypopituitarism. (11837807)
2002
33
A case of non-functioning pituitary adenoma with Cushing's syndrome upon recurrence. (11837535)
2001
34
Metamorphosis of a non-functioning pituitary adenoma to Cushing's disease. (12138984)
2001
35
In vivo secretory potential and the effect of combination therapy with octreotide and cabergoline in patients with clinically non-functioning pituitary adenomas. (11167922)
2001
36
Growth promoting effect of human plasma ultrafiltrate bioactive fraction (TBP) for human non-functioning pituitary adenoma cells in vitro. (11194707)
2000
37
Long-term treatment with the dopamine agonist quinagolide of patients with clinically non-functioning pituitary adenoma. (11078985)
2000
38
Spontaneous resolution of a non-functioning pituitary adenoma following an apoplexy. (11025642)
2000
39
Somatostatin and its analog lanreotide inhibit the proliferation of dispersed human non-functioning pituitary adenoma cells in vitro. (10526255)
1999
40
A case of non-functioning pituitary adenoma accompanied by a large cyst. (9638270)
1998
41
Unique binding pattern to concanavalin A lectin of glycoprotein hormones alpha-subunit hypersecreted by non-functioning pituitary adenomas. (9437241)
1997
42
The correlation of Ki-67 staining indices with tumour doubling times in regrowing non-functioning pituitary adenomas. (9030353)
1996
43
Acute and chronic effects of octreotide on thyroid axis in growth hormone-secreting and clinically non-functioning pituitary adenomas. (7655643)
1995
44
Effects of long-term treatment with the gonadotropin-releasing hormone analog nafarelin in patients with non-functioning pituitary adenomas. (8162161)
1994
45
Effect of bromocriptine and SMS 201-995 on growth of human somatotrophic and non-functioning pituitary adenoma cells in vitro. (8124483)
1994
46
An audit of selected patients with non-functioning pituitary adenoma treated by transsphenoidal surgery without irradiation. (7828355)
1994
47
A case of sellar chordoma mimicking a non-functioning pituitary adenoma with survival of more than 10 years. (8220788)
1993
48
Rapid improvement of visual defects with parenteral depot-bromocriptine in a patient with a non-functioning pituitary adenoma. (2634611)
1989
49
Bromocriptine therapy for non-functioning pituitary adenoma. (2605786)
1989
50
Hypercortisolism due to an autonomously functioning pituitary adenoma: limitations in diagnostic test procedures. (2846626)
1988

Variations for Functioning Pituitary Adenoma

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Expression for genes affiliated with Functioning Pituitary Adenoma

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Functioning Pituitary Adenoma

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Pathways for genes affiliated with Functioning Pituitary Adenoma

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51PathCards, 56Reactome, 13EMD Millipore, 39NCBI BioSystems Database, 31KEGG
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Compounds for genes affiliated with Functioning Pituitary Adenoma

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30IUPHAR, 46Novoseek, 12DrugBank, 62Tocris Bioscience, 25HMDB
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Compounds related to Functioning Pituitary Adenoma according to GeneCards/GeneDecks:

(show top 50)    (show all 64)
idCompoundScoreTop Affiliating Genes
1[125i]tyr3 sms 201-9953010.0SSTR5, SSTR2
2bim 230603010.0SSTR5, SSTR2
3bim 230593010.0SSTR5, SSTR2
4l-363,3013010.0SSTR2, SSTR5
5bim 230563010.0SSTR5, SSTR2
6boc-ate3010.0SSTR5, SSTR2
7[111in,90y]dota-oc3010.0SSTR5, SSTR2
8noc-ate309.9SSTR2, SSTR5
9[111in,90y]dota-lan309.9SSTR2, SSTR5
10[111in,90y]dota-toc309.9SSTR2, SSTR5
11bim 23197309.9SSTR5, SSTR2
12[111in]dota-boc-ate309.9SSTR2, SSTR5
13bim 23023309.9SSTR2, SSTR5
14[111in]dota-noc309.9SSTR2, SSTR5
15[111in]dota-noc-ate309.9SSTR2, SSTR5
16mk-678309.9SSTR2, SSTR5
17bim 23030309.9SSTR2, SSTR5
18[111in,90y]dota-noc309.9SSTR2, SSTR5
19som-230309.9SSTR2, SSTR5
20cgp 23996309.9SSTR5, SSTR2
21ke 108309.9SSTR2, SSTR5
22l-362,855309.9SSTR2, SSTR5
23bim 23627309.8SSTR2, SSTR5
24bim 23454309.8SSTR2, SSTR5
25[l-tyr8]cyn 154806309.8SSTR2, SSTR5
26tyr-3-octreotide469.8SSTR2, SST
27[d-tyr8]cyn 154806309.8SSTR2, SSTR5
28bim 23052309.8SSTR5, SSTR2
29[125i]ltt-srif-28309.8SSTR2, SSTR5
30[125i]tyr10-cst14309.8SSTR2, SSTR5
31srif-14309.7SSTR2, SSTR5
32srif-28309.7SSTR2, SSTR5
33cst-17309.7SSTR2, SSTR5
34[125i]cgp 23996309.7SSTR2, SSTR5
35cst-14309.6SSTR2, SSTR5
36pasireotide46 1210.5SSTR2, SST, SSTR5
37(1r,1s,3r/1r,1r,3s)-l-054,264629.5SSTR5, SST, SSTR2
38cyclosomatostatin629.5SSTR5, SST, SSTR2
39cyn 154806629.5SSTR5, SST, SSTR2
40somatostatin62 2510.5SSTR5, SST, SSTR2
41vapreotide46 30 1211.5SSTR5, SST, SSTR2
42111in-pentetreotide469.5SSTR5, SST, SSTR2
43lanreotide46 3010.5SSTR2, SST, SSTR5
44dtpa469.4SSTR2, SST
45octreotide46 62 30 1212.4SSTR5, SST, SSTR2
46spec-t469.2SSTR2, SST, ADM
47mibg469.2SST, ADM
48glyceraldehyde 3-phosphate468.9ADM, SSTR5, SSTR2
49acth468.8ADM, SSTR5, SST, SSTR2
50glucose468.1SSTR2, SST, ADM, RXRG

GO Terms for genes affiliated with Functioning Pituitary Adenoma

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17Gene Ontology
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Biological processes related to Functioning Pituitary Adenoma according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGO:0071879.5SSTR2, SSTR5
2response to starvationGO:0425949.4SSTR2, ADM
3heart developmentGO:0075079.4ADM, RXRG
4digestionGO:0075869.1SSTR2, SST
5adenylate cyclase-inhibiting G-protein coupled receptor signaling pathwayGO:0071939.0GNAI2, SSTR2
6cell-cell signalingGO:0072679.0SSTR2, SST, ADM
7G-protein coupled receptor signaling pathwayGO:0071868.8GNAI2, SSTR5, SST
8response to nutrientGO:0075848.8GNAI2, SST, SSTR2
9negative regulation of cell proliferationGO:0082858.6SSTR2, SST, SSTR5, ADM

Molecular functions related to Functioning Pituitary Adenoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:0051799.3SST, ADM
2somatostatin receptor activityGO:0049949.2SSTR2, SSTR5

Products for genes affiliated with Functioning Pituitary Adenoma

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Sources for Functioning Pituitary Adenoma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet