MCID: FNC007
MIFTS: 37

Functioning Pituitary Adenoma

Categories: Endocrine diseases, Cancer diseases

Aliases & Classifications for Functioning Pituitary Adenoma

MalaCards integrated aliases for Functioning Pituitary Adenoma:

Name: Functioning Pituitary Adenoma 12 14
Secretory Adenoma of the Pituitary Gland 12
Pituitary Adenoma, Functioning 69

Classifications:



External Ids:

Disease Ontology 12 DOID:5395
NCIt 46 C8388
UMLS 69 C0854486

Summaries for Functioning Pituitary Adenoma

MalaCards based summary : Functioning Pituitary Adenoma, also known as secretory adenoma of the pituitary gland, is related to non-functioning pituitary adenoma and acth-secreting pituitary adenoma. An important gene associated with Functioning Pituitary Adenoma is SST (Somatostatin), and among its related pathways/superpathways are Peptide ligand-binding receptors and Jak-STAT signaling pathway (KEGG). Affiliated tissues include pituitary, prostate and testes, and related phenotypes are homeostasis/metabolism and endocrine/exocrine gland

Related Diseases for Functioning Pituitary Adenoma

Diseases related to Functioning Pituitary Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 150)
# Related Disease Score Top Affiliating Genes
1 non-functioning pituitary adenoma 32.9 GH1 GHR MUC1 PTPN3 S100B SST
2 acth-secreting pituitary adenoma 31.9 POMC PRL
3 pituitary adenoma 1, multiple types 31.0 AIP GH1 PRL SST
4 lymphocytic hypophysitis 30.1 GH1 POMC
5 pituitary carcinoma 30.1 POMC SST
6 hypoadrenalism 30.1 GH1 POMC
7 hypopituitarism 30.0 GH1 POMC PRL
8 pituitary apoplexy 29.5 AIP POMC PRL
9 adrenal gland hyperfunction 29.4 GH1 POMC PRL SST
10 meningioma, familial 29.4 MEN1 MUC1 S100B SST
11 pheochromocytoma 29.3 MEN1 POMC SST
12 adenoma 29.3 AIP GH1 MEN1 POMC PRL SST
13 pituitary adenoma 28.7 AIP GH1 MEN1 POMC PRL SST
14 hyperprolactinemia 28.3 DRD2 GH1 POMC PRL SST TRH
15 pituitary tumors 27.8 AIP GH1 MEN1 POMC PRL SST
16 acromegaly 26.9 AIP GH1 GHR MEN1 POMC PRL
17 pituitary adenoma, prolactin-secreting 26.7 AIP DRD2 GH1 MEN1 POMC PRL
18 functionless pituitary adenoma 11.4
19 pituitary adenoma 4, acth-secreting 11.0
20 pituitary adenoma 2, growth hormone-secreting 11.0
21 pituitary adenoma 5, multiple types 11.0
22 pituitary adenoma 3, multiple types 11.0
23 isolated growth hormone deficiency, type ib 10.5 GH1 GHR
24 fibrous dysplasia/mccune-albright syndrome 10.4 GH1 PRL
25 villous adenoma 10.4 MUC1 SST
26 ampulla of vater neoplasm 10.4 MUC1 SST
27 localized hypertrophic neuropathy 10.4 MUC1 S100B
28 sclerosing perineurioma 10.4 MUC1 S100B
29 bronchus adenoma 10.4 POMC SST
30 bronchial adenomas/carcinoids childhood 10.4 POMC SST
31 intracranial cysts 10.4 MUC1 S100B
32 reticular perineurioma 10.4 MUC1 S100B
33 acidophil adenoma 10.4 POMC SST
34 epithelioid malignant peripheral nerve sheath tumor 10.4 MUC1 S100B
35 ossifying fibromyxoid tumor 10.4 MUC1 S100B
36 fibrous meningioma 10.4 MUC1 S100B
37 chordoid meningioma 10.4 MUC1 S100B
38 myxofibrosarcoma 10.4 MUC1 S100B
39 syringocystadenoma papilliferum 10.4 MUC1 S100B
40 eccrine porocarcinoma 10.4 MUC1 S100B
41 aggressive digital papillary adenocarcinoma 10.4 MUC1 S100B
42 chordoid glioma 10.4 MUC1 S100B
43 myxopapillary ependymoma 10.4 MUC1 S100B
44 monophasic synovial sarcoma 10.4 MUC1 S100B
45 syringoma 10.4 MUC1 S100B
46 anaplastic ependymoma 10.4 MUC1 S100B
47 pleomorphic liposarcoma 10.4 MUC1 S100B
48 spindle cell sarcoma 10.3 MUC1 S100B
49 perineurioma 10.3 MUC1 S100B
50 spiradenoma 10.3 MUC1 S100B

Graphical network of the top 20 diseases related to Functioning Pituitary Adenoma:



Diseases related to Functioning Pituitary Adenoma

Symptoms & Phenotypes for Functioning Pituitary Adenoma

MGI Mouse Phenotypes related to Functioning Pituitary Adenoma:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.91 GHR MEN1 POMC PRL S100B SST
2 endocrine/exocrine gland MP:0005379 9.87 GHR MEN1 POMC PRL AIP TRH
3 integument MP:0010771 9.63 DRD2 GHR POMC PRL S100B AIP
4 liver/biliary system MP:0005370 9.43 GHR MEN1 POMC PRL AIP DRD2
5 neoplasm MP:0002006 9.02 MEN1 POMC PRL AIP DRD2

Drugs & Therapeutics for Functioning Pituitary Adenoma

Search Clinical Trials , NIH Clinical Center for Functioning Pituitary Adenoma

Genetic Tests for Functioning Pituitary Adenoma

Anatomical Context for Functioning Pituitary Adenoma

MalaCards organs/tissues related to Functioning Pituitary Adenoma:

38
Pituitary, Prostate, Testes, Endothelial, Thyroid, Brain, Lung

Publications for Functioning Pituitary Adenoma

Articles related to Functioning Pituitary Adenoma:

(show top 50) (show all 100)
# Title Authors Year
1
Malignant transformation in non-functioning pituitary adenomas (pituitary carcinoma). ( 29299820 )
2018
2
Mortality in patients with non-functioning pituitary adenoma. ( 29344906 )
2018
3
Increased I^a89catenin and c-myc expression predict aggressive growth of non-functioning pituitary adenomas: An assessment using a tissue microarray-based approach. ( 28260015 )
2017
4
Non-functioning pituitary adenoma underwent surgery: A multicenter retrospective study over the last four decades (1977-2015). ( 28389053 )
2017
5
Incidence of malignant tumours in patients with a non-functioning pituitary adenoma. ( 28274953 )
2017
6
SNPs in the aryl hydrocarbon receptor-interacting protein gene associated with sporadic non-functioning pituitary adenoma. ( 26998050 )
2016
7
Higher Incidence of Morbidity in Women than Men with Non-functioning Pituitary Adenoma: a Swedish Nationwide Study. ( 27147638 )
2016
8
Time trends of mortality in patients with non-functioning pituitary adenoma: a Swedish nationwide study. ( 27743172 )
2016
9
Clinical Concerns about Recurrence of Non-Functioning Pituitary Adenoma. ( 27195254 )
2016
10
Relationship of each anterior pituitary hormone deficiency to the size of non-functioning pituitary adenoma in the hospitalized patients. ( 27534814 )
2016
11
Hypothalamic-Pituitary Axis in Non-Functioning Pituitary Adenomas: Focus on the Prevalence of Isolated Central Hypoadrenalism. ( 25924873 )
2015
12
Non-functioning pituitary adenoma: when and how to operate? What pathologic criteria for typing? ( 26070464 )
2015
13
MORTALITY IN PATIENTS WITH NON-FUNCTIONING PITUITARY ADENOMA IS INCREASED: SYSTEMATIC ANALYSIS OF 546 CASES WITH LONG FOLLOW-UP. ( 26546611 )
2015
14
Neuro-ophthalmologic exploration in non-functioning pituitary adenoma. ( 26070465 )
2015
15
Biological and radiological exploration and management of non-functioning pituitary adenoma. ( 26122495 )
2015
16
Dopamine 2 and somatostatin 1-5 receptors coexpression in clinically non-functioning pituitary adenomas. ( 25536318 )
2015
17
Brain abnormalities on MRI in non-functioning pituitary adenoma patients treated with or without postoperative radiotherapy. ( 25596913 )
2015
18
Post-surgical management of non-functioning pituitary adenoma. ( 26116412 )
2015
19
Management of clinically non-functioning pituitary adenoma. ( 26072284 )
2015
20
Cluster headache associated with a clinically non-functioning pituitary adenoma: a case report. ( 25526868 )
2014
21
Medical management of functioning pituitary adenoma: an update. ( 26236804 )
2014
22
Candida albicans endophthalmitis in a patient with a non-functioning pituitary adenoma evolving into Cushingx^s disease: A case report. ( 25379398 )
2014
23
Medical management of functioning pituitary adenoma: an update. ( 25446388 )
2014
24
Analysis of short- and long-term metabolic effects of growth hormone replacement therapy in adult patients with craniopharyngioma and non-functioning pituitary adenoma. ( 25330765 )
2014
25
Results of Immunohistochemical staining of cell cycle regulators - the prediction of recurrence of functioning pituitary adenoma. ( 24067736 )
2013
26
Self-perception of cognitive function among patients with active acromegaly, controlled acromegaly, and non-functional pituitary adenoma: a pilot study. ( 24282035 )
2013
27
Spontaneous regression of non-functioning pituitary adenoma due to pituitary apoplexy following anticoagulation treatment - a case report and review of the literature. ( 23450448 )
2013
28
Functional Pituitary Adenoma Recurrence after Surgical Resection. ( 24215871 )
2013
29
ZAC1 and SSTR2 are downregulated in non-functioning pituitary adenomas but not in somatotropinomas. ( 24098585 )
2013
30
Peptide receptor radionuclide therapy in a patient with disabling non-functioning pituitary adenoma. ( 23740146 )
2013
31
Combined gangliocytoma and non-functioning pituitary adenoma of the pituitary gland. ( 22824692 )
2012
32
Intraoperative MRI and endocrinological outcome of transsphenoidal surgery for non-functioning pituitary adenoma. ( 22286656 )
2012
33
Dopamine 2 receptor expression in various pathological types of clinically non-functioning pituitary adenomas. ( 21597974 )
2012
34
Treatment with octreotide LAR in clinically non-functioning pituitary adenoma: results from a case-control study. ( 22207350 )
2012
35
Expression of genes FOLR1, BAG1 and LAPTM4B in functioning and non-functioning pituitary adenomas. ( 23023342 )
2012
36
Expression of CRABP1, GRP, and RERG mRNA in clinically non-functioning and functioning pituitary adenomas. ( 21270509 )
2011
37
Pituitary apoplexy in non-functioning pituitary adenomas: long term follow up is important because of significant numbers of tumour recurrences. ( 21521336 )
2011
38
Can we ever stop imaging in surgically treated and radiotherapy-naive patients with non-functioning pituitary adenoma? ( 21900406 )
2011
39
Co-expression of somatostatin receptor subtypes and estrogen receptor-I+ mRNAs by non-functioning pituitary adenomas in young patients. ( 20797424 )
2011
40
Non-functioning pituitary adenoma and concomitant Rathke's cleft cyst. ( 21934255 )
2011
41
Apoplexy in non functioning pituitary adenoma after one dose of leuprolide as treatment for prostate cancer. ( 19842040 )
2010
42
Metabolic, cardiovascular, and cerebrovascular outcomes in growth hormone-deficient subjects with previous cushing's disease or non-functioning pituitary adenoma. ( 20022992 )
2010
43
Prevalence of gsp oncogene in somatotropinomas and clinically non-functioning pituitary adenomas: our experience. ( 18642089 )
2009
44
Comparing progression of non-functioning pituitary adenomas in hypopituitarism patients with and without long-term GH replacement therapy. ( 19734242 )
2009
45
GH replacement in patients with non-functioning pituitary adenoma (NFA) treated solely by surgery is not associated with increased risk of tumour recurrence. ( 19236640 )
2009
46
Non-functioning pituitary adenomas: clinical feature, laboratorial and imaging assessment, therapeutic management and outcome. ( 19347183 )
2009
47
Non-functioning pituitary adenomas infrequently harbor G-protein gene mutations. ( 19169048 )
2008
48
Efficacy of a dopamine-somatostatin chimeric molecule, BIM-23A760, in the control of cell growth from primary cultures of human non-functioning pituitary adenomas: a multi-center study. ( 18509006 )
2008
49
Lymphocytic hypophysitis occurring simultaneously with a functioning pituitary adenoma. ( 18497455 )
2008
50
Effects of selective somatostatin analogs and cortistatin on cell viability in cultured human non-functioning pituitary adenomas. ( 18276067 )
2008

Variations for Functioning Pituitary Adenoma

Expression for Functioning Pituitary Adenoma

Search GEO for disease gene expression data for Functioning Pituitary Adenoma.

Pathways for Functioning Pituitary Adenoma

GO Terms for Functioning Pituitary Adenoma

Cellular components related to Functioning Pituitary Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.73 GH1 GHR MUC1 POMC S100B SST
2 extracellular region GO:0005576 9.56 GH1 GHR MUC1 POMC PRL S100B
3 endosome lumen GO:0031904 9.16 GH1 PRL
4 growth hormone receptor complex GO:0070195 8.62 GH1 GHR

Biological processes related to Functioning Pituitary Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of receptor activity GO:0010469 9.65 GH1 POMC PRL SST TRH
2 hormone-mediated signaling pathway GO:0009755 9.48 GHR TRH
3 response to morphine GO:0043278 9.46 DRD2 GHR
4 adult walking behavior GO:0007628 9.43 DRD2 TRH
5 regulation of multicellular organism growth GO:0040014 9.4 GHR PRL
6 positive regulation of receptor internalization GO:0002092 9.37 DRD2 GH1
7 positive regulation of multicellular organism growth GO:0040018 9.33 DRD2 GH1 GHR
8 growth hormone receptor signaling pathway GO:0060396 9.32 GH1 GHR
9 positive regulation of JAK-STAT cascade GO:0046427 9.13 GH1 GHR PRL
10 JAK-STAT cascade involved in growth hormone signaling pathway GO:0060397 8.8 GH1 GHR PRL

Molecular functions related to Functioning Pituitary Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.02 GH1 POMC PRL SST TRH
2 prolactin receptor binding GO:0005148 8.96 GH1 PRL

Sources for Functioning Pituitary Adenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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