MCID: FNC007
MIFTS: 40

Functioning Pituitary Adenoma

Categories: Cancer diseases, Endocrine diseases

Aliases & Classifications for Functioning Pituitary Adenoma

MalaCards integrated aliases for Functioning Pituitary Adenoma:

Name: Functioning Pituitary Adenoma 12 14
Secretory Adenoma of the Pituitary Gland 12
Pituitary Adenoma, Functioning 69

Classifications:



External Ids:

Disease Ontology 12 DOID:5395
NCIt 47 C8388
UMLS 69 C0854486

Summaries for Functioning Pituitary Adenoma

MalaCards based summary : Functioning Pituitary Adenoma, also known as secretory adenoma of the pituitary gland, is related to pituitary adenoma, acth-secreting and non-functioning pituitary adenoma. An important gene associated with Functioning Pituitary Adenoma is SST (Somatostatin), and among its related pathways/superpathways are Peptide ligand-binding receptors and Jak-STAT signaling pathway (KEGG). The drugs Hydrocortisone and Prednisone have been mentioned in the context of this disorder. Affiliated tissues include pituitary, testes and thyroid, and related phenotypes are homeostasis/metabolism and endocrine/exocrine gland

Related Diseases for Functioning Pituitary Adenoma

Diseases related to Functioning Pituitary Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 148)
id Related Disease Score Top Affiliating Genes
1 pituitary adenoma, acth-secreting 27.6 AIP DRD2 GH1 MEN1 POMC PRL
2 non-functioning pituitary adenoma 12.2
3 functionless pituitary adenoma 11.2
4 radioulnar synostosis with amegakaryocytic thrombocytopenia 1 10.7 GH1 GHR
5 logopenic progressive aphasia 10.7 MUC1 S100B
6 heiner syndrome 10.7 MUC1 S100B
7 meningitis and encephalitis 10.7 MUC1 S100B
8 dedifferentiated liposarcoma 10.7 MUC1 S100B
9 spleen angiosarcoma 10.7 MUC1 S100B
10 myoma 10.7 MUC1 S100B
11 g6pc3 deficiency 10.7 GH1 PRL
12 mucinous ovarian cystadenoma 10.7 MUC1 S100B
13 enteric pattern testicular yolk sac tumor 10.7 MUC1 S100B
14 tabes dorsalis 10.7 MUC1 SST
15 noninvasive malignant thymoma 10.7 MUC1 S100B
16 reticular pattern testicular yolk sac tumor 10.7 MUC1 S100B
17 pancreatic intraductal papillary-colloid carcinoma 10.6 MUC1 S100B
18 growth hormone insensitivity, partial 10.6 GH1 GHR
19 lice infestation 10.6 MUC1 S100B
20 fibroma 10.6 MUC1 SST
21 gastric papillary adenocarcinoma 10.6 MUC1 S100B
22 pleural empyema 10.6 MUC1 S100B
23 ganglioglioma 10.6 MUC1 S100B
24 anaplastic oligodendroglioma 10.6 MUC1 S100B
25 prolactin producing pituitary tumor 10.6 POMC SST
26 pituitary adenoma 10.6
27 adenoma 10.6
28 vulvar squamous papilloma 10.6 MUC1 S100B
29 spindle cell liposarcoma 10.6 MUC1 S100B
30 lymphoma, gastric non hodgkins type 10.6 GH1 POMC
31 coronary restenosis 10.6 MUC1 S100B
32 renal pelvis carcinoma 10.6 POMC SST
33 hydromyelia 10.6 PRL S100B
34 pulmonary venoocclusive disease 10.6 MUC1 S100B
35 prostate disease 10.5 MUC1 S100B
36 hypodermyasis 10.5 GH1 POMC
37 phobic disorder 10.5 MUC1 S100B
38 pityriasis rotunda 10.5 GH1 PRL
39 dense deposit disease 10.5 MUC1 S100B
40 vulvar keratoacanthoma-like carcinoma 10.5 MUC1 S100B
41 47,xyy syndrome 10.5 GH1 PRL
42 patent ductus arteriosus and bicuspid aortic valve with hand anomalies 10.5 MUC1 S100B
43 olfactory nerve neoplasm 10.4 POMC PRL
44 pemphigus foliaceus 10.4 MEN1 SST
45 osteoclast-like giant cell neoplasm of the pancreas 10.4 POMC PRL
46 pandas 10.4 MEN1 SST
47 combined t cell and b cell immunodeficiency 10.4 GH1 PRL SST
48 epicardium cancer 10.4 MUC1 S100B
49 ulcerative blepharitis 10.4 POMC PRL
50 malignant breast melanoma 10.4 DRD2 S100B

Graphical network of the top 20 diseases related to Functioning Pituitary Adenoma:



Diseases related to Functioning Pituitary Adenoma

Symptoms & Phenotypes for Functioning Pituitary Adenoma

MGI Mouse Phenotypes related to Functioning Pituitary Adenoma:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.91 POMC PRL S100B SST TRH AIP
2 endocrine/exocrine gland MP:0005379 9.87 AIP DRD2 GHR MEN1 POMC PRL
3 integument MP:0010771 9.63 AIP DRD2 GHR POMC PRL S100B
4 liver/biliary system MP:0005370 9.43 AIP DRD2 GHR MEN1 POMC PRL
5 neoplasm MP:0002006 9.02 AIP DRD2 MEN1 POMC PRL

Drugs & Therapeutics for Functioning Pituitary Adenoma

Drugs for Functioning Pituitary Adenoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 67)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hydrocortisone Approved, Vet_approved Phase 4 50-23-7 5754 657311
2
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
3
Octreotide Approved, Investigational Phase 4 83150-76-9 383414 6400441
4
Butyric Acid Experimental Phase 4 107-92-6 264
5 Anesthetics Phase 4
6 Anti-Inflammatory Agents Phase 4,Phase 2
7 Antineoplastic Agents, Hormonal Phase 4,Phase 2
8 Cortisol succinate Phase 4
9 glucocorticoids Phase 4,Phase 2
10 Hormone Antagonists Phase 4,Phase 2
11 Hormones Phase 4,Phase 2
12 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2
13 Hydrocortisone 17-butyrate 21-propionate Phase 4
14 Hydrocortisone acetate Phase 4
15 Hydrocortisone-17-butyrate Phase 4
16 Gastrointestinal Agents Phase 4,Phase 2
17 insulin Phase 4
18 Insulin, Globin Zinc Phase 4
19
Cabergoline Approved Phase 3 81409-90-7 54746
20
Dopamine Approved Phase 3 51-61-6, 62-31-7 681
21 Antiparkinson Agents Phase 3
22 Autonomic Agents Phase 3,Phase 2
23 Dopamine Agents Phase 3
24 Dopamine agonists Phase 3
25 Neurotransmitter Agents Phase 3
26 Peripheral Nervous System Agents Phase 3,Phase 2
27 Protective Agents Phase 3,Phase 2
28
Somatostatin Approved Phase 2 38916-34-6, 51110-01-1 53481605
29
Methylprednisolone Approved, Vet_approved Phase 2 83-43-2 6741
30
Prednisolone Approved, Vet_approved Phase 2 50-24-8 5755
31
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
32
Niacin Approved, Investigational, Nutraceutical Phase 2 59-67-6 938
33
Nicotinamide Approved, Nutraceutical Phase 2 98-92-0 936
34 Adrenocorticotropic Hormone Phase 2
35 Antiemetics Phase 2
36 Methylprednisolone acetate Phase 2
37 Methylprednisolone Hemisuccinate Phase 2
38 Micronutrients Phase 2
39 Neuroprotective Agents Phase 2
40 Nicotinic Acids Phase 2
41 Prednisolone acetate Phase 2
42 Prednisolone hemisuccinate Phase 2
43 Prednisolone phosphate Phase 2
44 Trace Elements Phase 2
45 Vitamin B Complex Phase 2
46 Vitamins Phase 2
47 Folate Nutraceutical Phase 2
48 Vitamin B3 Nutraceutical Phase 2
49 Vitamin B9 Nutraceutical Phase 2
50 lanreotide Approved 108736-35-2

Interventional clinical trials:

(show all 17)

id Name Status NCT ID Phase Drugs
1 Effect of Perioperative Glucocorticoid Replacement on Prognosis of Surgical Patients With Sellar Lesions Unknown status NCT02190994 Phase 4 Hydrocortisone;Prednisone
2 Preoperative Octreotide Treatment of Acromegaly Completed NCT00521300 Phase 4 Octreotide
3 Adipokine Profile in Patients With Cushing's Disease on Pasireotide Treatment Completed NCT03080181 Phase 4 Pasireotide 0.6 MG/ML
4 Octreotide Efficacy and Safety in First-line Acromegalic Patients Completed NCT00171886 Phase 4 Octreotide
5 Dopamine Agonist Treatment of Non-functioning Pituitary Adenomas Recruiting NCT02288962 Phase 3 cabergoline
6 Enhancement of Neurocognitive Functions by Hippocampal Sparing Radiotherapy Recruiting NCT01849484 Phase 2
7 Pasireotide LAR Therapy of Silent Corticotroph Pituitary Tumors Recruiting NCT02749227 Phase 2 Pasireotide LAR
8 Targeting Iatrogenic Cushing's Syndrome With 11β-hydroxysteroid Dehydrogenase Type 1 Inhibition Recruiting NCT03111810 Phase 2 AZD4017 and prednisolone;Placebo Oral Tablet and prednisolone
9 Impact of Somatostatin Analogs vs. Surgery on Glucose Metabolism in Acromegaly Completed NCT00703079 Octreotide-LAR or lanreotide
10 Cognition, Steroids, and Imaging in Cushings Disease Completed NCT00081341
11 Comparison of The Effects of Sevoflurane, Desflurane and Total Intravenous Anaesthesia on Pulmonary Function Tests Recruiting NCT02709863 Sevoflurane;Desflurane;Propofol
12 Prospective Study of Clinically Nonfunctioning Pituitary Adenomas Recruiting NCT01556230
13 Evaluation of Patients With Thyroid Disorders Recruiting NCT00001159
14 Heart Rate Variability (HRV) in Pituitary Adenoma Recruiting NCT03164148
15 Quality of Life, Fatigue and Cognitive, Affective and Emotional Dysfunction in Patients With Cushing's Syndrome Recruiting NCT03211624
16 Rhinological Outcomes in Endonasal Pituitary Surgery Active, not recruiting NCT01504399
17 Adult Growth Hormone Deficiency and Cardiovascular Risk Terminated NCT00720902 Growth hormone releasing hormone (GHRH) and arginine

Search NIH Clinical Center for Functioning Pituitary Adenoma

Genetic Tests for Functioning Pituitary Adenoma

Anatomical Context for Functioning Pituitary Adenoma

MalaCards organs/tissues related to Functioning Pituitary Adenoma:

39
Pituitary, Testes, Thyroid, Heart, Prostate, Brain, Endothelial

Publications for Functioning Pituitary Adenoma

Articles related to Functioning Pituitary Adenoma:

(show top 50) (show all 98)
id Title Authors Year
1
Incidence of malignant tumours in patients with a non-functioning pituitary adenoma. ( 28274953 )
2017
2
Non-functioning pituitary adenoma underwent surgery: A multicenter retrospective study over the last four decades (1977-2015). ( 28389053 )
2017
3
Increased I^a89catenin and c-myc expression predict aggressive growth of non-functioning pituitary adenomas: An assessment using a tissue microarray-based approach. ( 28260015 )
2017
4
Relationship of each anterior pituitary hormone deficiency to the size of non-functioning pituitary adenoma in the hospitalized patients. ( 27534814 )
2016
5
Time trends of mortality in patients with non-functioning pituitary adenoma: a Swedish nationwide study. ( 27743172 )
2016
6
SNPs in the aryl hydrocarbon receptor-interacting protein gene associated with sporadic non-functioning pituitary adenoma. ( 26998050 )
2016
7
Clinical Concerns about Recurrence of Non-Functioning Pituitary Adenoma. ( 27195254 )
2016
8
Higher Incidence of Morbidity in Women than Men with Non-functioning Pituitary Adenoma: a Swedish Nationwide Study. ( 27147638 )
2016
9
Neuro-ophthalmologic exploration in non-functioning pituitary adenoma. ( 26070465 )
2015
10
Dopamine 2 and somatostatin 1-5 receptors coexpression in clinically non-functioning pituitary adenomas. ( 25536318 )
2015
11
Non-functioning pituitary adenoma: when and how to operate? What pathologic criteria for typing? ( 26070464 )
2015
12
Post-surgical management of non-functioning pituitary adenoma. ( 26116412 )
2015
13
Brain abnormalities on MRI in non-functioning pituitary adenoma patients treated with or without postoperative radiotherapy. ( 25596913 )
2015
14
MORTALITY IN PATIENTS WITH NON-FUNCTIONING PITUITARY ADENOMA IS INCREASED: SYSTEMATIC ANALYSIS OF 546 CASES WITH LONG FOLLOW-UP. ( 26546611 )
2015
15
Management of clinically non-functioning pituitary adenoma. ( 26072284 )
2015
16
Hypothalamic-Pituitary Axis in Non-Functioning Pituitary Adenomas: Focus on the Prevalence of Isolated Central Hypoadrenalism. ( 25924873 )
2015
17
Biological and radiological exploration and management of non-functioning pituitary adenoma. ( 26122495 )
2015
18
Cluster headache associated with a clinically non-functioning pituitary adenoma: a case report. ( 25526868 )
2014
19
Medical management of functioning pituitary adenoma: an update. ( 26236804 )
2014
20
Medical management of functioning pituitary adenoma: an update. ( 25446388 )
2014
21
Candida albicans endophthalmitis in a patient with a non-functioning pituitary adenoma evolving into Cushingx^s disease: A case report. ( 25379398 )
2014
22
Analysis of short- and long-term metabolic effects of growth hormone replacement therapy in adult patients with craniopharyngioma and non-functioning pituitary adenoma. ( 25330765 )
2014
23
Self-perception of cognitive function among patients with active acromegaly, controlled acromegaly, and non-functional pituitary adenoma: a pilot study. ( 24282035 )
2013
24
ZAC1 and SSTR2 are downregulated in non-functioning pituitary adenomas but not in somatotropinomas. ( 24098585 )
2013
25
Functional Pituitary Adenoma Recurrence after Surgical Resection. ( 24215871 )
2013
26
Spontaneous regression of non-functioning pituitary adenoma due to pituitary apoplexy following anticoagulation treatment - a case report and review of the literature. ( 23450448 )
2013
27
Peptide receptor radionuclide therapy in a patient with disabling non-functioning pituitary adenoma. ( 23740146 )
2013
28
Results of Immunohistochemical staining of cell cycle regulators - the prediction of recurrence of functioning pituitary adenoma. ( 24067736 )
2013
29
Combined gangliocytoma and non-functioning pituitary adenoma of the pituitary gland. ( 22824692 )
2012
30
Expression of genes FOLR1, BAG1 and LAPTM4B in functioning and non-functioning pituitary adenomas. ( 23023342 )
2012
31
Dopamine 2 receptor expression in various pathological types of clinically non-functioning pituitary adenomas. ( 21597974 )
2012
32
Treatment with octreotide LAR in clinically non-functioning pituitary adenoma: results from a case-control study. ( 22207350 )
2012
33
Intraoperative MRI and endocrinological outcome of transsphenoidal surgery for non-functioning pituitary adenoma. ( 22286656 )
2012
34
Co-expression of somatostatin receptor subtypes and estrogen receptor-I+ mRNAs by non-functioning pituitary adenomas in young patients. ( 20797424 )
2011
35
Expression of CRABP1, GRP, and RERG mRNA in clinically non-functioning and functioning pituitary adenomas. ( 21270509 )
2011
36
Pituitary apoplexy in non-functioning pituitary adenomas: long term follow up is important because of significant numbers of tumour recurrences. ( 21521336 )
2011
37
Non-functioning pituitary adenoma and concomitant Rathke's cleft cyst. ( 21934255 )
2011
38
Can we ever stop imaging in surgically treated and radiotherapy-naive patients with non-functioning pituitary adenoma? ( 21900406 )
2011
39
Metabolic, cardiovascular, and cerebrovascular outcomes in growth hormone-deficient subjects with previous cushing's disease or non-functioning pituitary adenoma. ( 20022992 )
2010
40
Apoplexy in non functioning pituitary adenoma after one dose of leuprolide as treatment for prostate cancer. ( 19842040 )
2010
41
Prevalence of gsp oncogene in somatotropinomas and clinically non-functioning pituitary adenomas: our experience. ( 18642089 )
2009
42
Non-functioning pituitary adenomas: clinical feature, laboratorial and imaging assessment, therapeutic management and outcome. ( 19347183 )
2009
43
GH replacement in patients with non-functioning pituitary adenoma (NFA) treated solely by surgery is not associated with increased risk of tumour recurrence. ( 19236640 )
2009
44
Comparing progression of non-functioning pituitary adenomas in hypopituitarism patients with and without long-term GH replacement therapy. ( 19734242 )
2009
45
Medical therapy for clinically non-functioning pituitary adenomas. ( 18780796 )
2008
46
Lymphocytic hypophysitis occurring simultaneously with a functioning pituitary adenoma. ( 18497455 )
2008
47
Efficacy of a dopamine-somatostatin chimeric molecule, BIM-23A760, in the control of cell growth from primary cultures of human non-functioning pituitary adenomas: a multi-center study. ( 18509006 )
2008
48
Non-functioning pituitary adenomas infrequently harbor G-protein gene mutations. ( 19169048 )
2008
49
Effects of selective somatostatin analogs and cortistatin on cell viability in cultured human non-functioning pituitary adenomas. ( 18276067 )
2008
50
Quantitative analysis of somatostatin receptor subtype (SSTR1-5) gene expression levels in somatotropinomas and non-functioning pituitary adenomas. ( 17218727 )
2007

Variations for Functioning Pituitary Adenoma

Expression for Functioning Pituitary Adenoma

Search GEO for disease gene expression data for Functioning Pituitary Adenoma.

Pathways for Functioning Pituitary Adenoma

GO Terms for Functioning Pituitary Adenoma

Cellular components related to Functioning Pituitary Adenoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.73 GH1 GHR MUC1 POMC S100B SST
2 extracellular region GO:0005576 9.56 GH1 GHR MUC1 POMC PRL S100B
3 endosome lumen GO:0031904 9.16 GH1 PRL
4 growth hormone receptor complex GO:0070195 8.62 GH1 GHR

Biological processes related to Functioning Pituitary Adenoma according to GeneCards Suite gene sharing:

(show all 11)
id Name GO ID Score Top Affiliating Genes
1 response to hypoxia GO:0001666 9.54 DRD2 MUC1 TRH
2 JAK-STAT cascade GO:0007259 9.49 GH1 GHR
3 response to morphine GO:0043278 9.48 DRD2 GHR
4 adult walking behavior GO:0007628 9.46 DRD2 TRH
5 hormone-mediated signaling pathway GO:0009755 9.43 GHR TRH
6 regulation of multicellular organism growth GO:0040014 9.4 GHR PRL
7 positive regulation of multicellular organism growth GO:0040018 9.33 DRD2 GH1 GHR
8 positive regulation of receptor internalization GO:0002092 9.32 DRD2 GH1
9 growth hormone receptor signaling pathway GO:0060396 9.26 GH1 GHR
10 positive regulation of JAK-STAT cascade GO:0046427 9.13 GH1 GHR PRL
11 JAK-STAT cascade involved in growth hormone signaling pathway GO:0060397 8.8 GH1 GHR PRL

Molecular functions related to Functioning Pituitary Adenoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.02 GH1 POMC PRL SST TRH
2 prolactin receptor binding GO:0005148 8.96 GH1 PRL

Sources for Functioning Pituitary Adenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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