MCID: FNG004
MIFTS: 31

Fungal Meningitis

Categories: Neuronal diseases

Aliases & Classifications for Fungal Meningitis

MalaCards integrated aliases for Fungal Meningitis:

Name: Fungal Meningitis 12 3 14
Meningitis, Fungal 41 69

Classifications:



External Ids:

Disease Ontology 12 DOID:11608
MeSH 41 D016921
SNOMED-CT 64 24321005
UMLS 69 C0085438

Summaries for Fungal Meningitis

Disease Ontology : 12 A meningitis that has material basis in a fungal infection.

MalaCards based summary : Fungal Meningitis, also known as meningitis, fungal, is related to cryptococcal meningitis and meningitis. An important gene associated with Fungal Meningitis is IFNG (Interferon Gamma), and among its related pathways/superpathways are NF-kappaB Signaling and Type II interferon signaling (IFNG). The drugs Amphotericin B and Fluconazole have been mentioned in the context of this disorder. Affiliated tissues include testes and brain, and related phenotype is cardiovascular system.

CDC : 3 Español: Meningitis micótica

Wikipedia : 72 Fungal meningitis refers to meningitis caused by a fungal... more...

Related Diseases for Fungal Meningitis

Graphical network of the top 20 diseases related to Fungal Meningitis:



Diseases related to Fungal Meningitis

Symptoms & Phenotypes for Fungal Meningitis

MGI Mouse Phenotypes related to Fungal Meningitis:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.1 CXCL10 FLNC GPR180 IFNG TRIM37 UNC119

Drugs & Therapeutics for Fungal Meningitis

Drugs for Fungal Meningitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Amphotericin B Approved, Investigational Phase 3 1397-89-3 5280965 14956
2
Fluconazole Approved, Investigational Phase 3 86386-73-4 3365
3
Sertraline Approved Phase 3 79617-96-2 68617
4 Antidepressive Agents Phase 3
5 Liposomal amphotericin B Phase 3
6 Neurotransmitter Agents Phase 3
7 Neurotransmitter Uptake Inhibitors Phase 3
8 Psychotropic Drugs Phase 3
9
Serotonin Phase 3 50-67-9 5202
10 Serotonin Agents Phase 3
11 Serotonin Uptake Inhibitors Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Adjunctive Sertraline for the Treatment of HIV-Associated Cryptococcal Meningitis Completed NCT01802385 Phase 3 Sertraline

Search NIH Clinical Center for Fungal Meningitis

Cochrane evidence based reviews: meningitis, fungal

Genetic Tests for Fungal Meningitis

Anatomical Context for Fungal Meningitis

MalaCards organs/tissues related to Fungal Meningitis:

38
Testes, Brain

Publications for Fungal Meningitis

Articles related to Fungal Meningitis:

(show top 50) (show all 68)
# Title Authors Year
1
Prevalence, healthcare resource utilization and overall burden of fungal meningitis in the United States. ( 29244019 )
2018
2
Epidemiological Effectiveness and Cost of a Fungal Meningitis Outbreak Response in New River Valley, Virginia: Local Health Department and Clinical Perspectives. ( 28578748 )
2017
3
Clinical Response, Outbreak Investigation, and Epidemiology of the Fungal Meningitis Epidemic in the United States: Systematic Review. ( 26681583 )
2016
4
Fungal meningitis caused by Lomentospora prolificans after allogeneic hematopoietic stem cell transplantation. ( 27258644 )
2016
5
Economic Evaluation of Fungal Meningitis Outbreak Response in New River Valley: Local Health Department Perspective. ( 26317059 )
2015
6
Causes and root causes of a multistate fungal meningitis outbreak. ( 25616150 )
2015
7
Utility of real-time PCR for detection of Exserohilum rostratum in body and tissue fluids during the multistate outbreak of fungal meningitis and other infections. ( 25520443 )
2015
8
Lack of IL-6 increases blood-brain barrier permeability in fungal meningitis. ( 25740137 )
2015
9
(1,3)-I^-d-glucan in cerebrospinal fluid for diagnosis of fungal meningitis associated with contaminated methylprednisolone injections. ( 25540391 )
2015
10
Estimated deaths and illnesses averted during fungal meningitis outbreak associated with contaminated steroid injections, United States, 2012-2013. ( 25989264 )
2015
11
Unraveling the biology of a fungal meningitis pathogen using chemical genetics. ( 25416953 )
2014
12
How gaps in regulation of compounding pharmacy set the stage for a multistate fungal meningitis outbreak. ( 25063265 )
2014
13
Utility of (1-3)-I^-D-Glucan Testing for Diagnostics and Monitoring Response to Treatment During the Multistate Outbreak of Fungal Meningitis and Other Infections. ( 24336827 )
2014
14
Trends in bacterial, mycobacterial, and fungal meningitis in England and Wales 2004-11: an observational study. ( 24508198 )
2014
15
Fungal meningitis in England and Wales. ( 25253404 )
2014
16
Whole-genome analysis of Exserohilum rostratum from an outbreak of fungal meningitis and other infections. ( 24951807 )
2014
17
Relapse of fungal meningitis associated with contaminated methylprednisolone. ( 23718153 )
2013
18
Exserohilum rostratum fungal meningitis associated with methylprednisolone injections. ( 23374119 )
2013
19
A real-time PCR assay for rapid detection and quantification of Exserohilum rostratum, a causative pathogen of fungal meningitis associated with injection of contaminated methylprednisolone. ( 23303500 )
2013
20
Fungal meningitis outbreak affects over 700. ( 23602160 )
2013
21
Fungal meningitis outbreak editorial. ( 24095660 )
2013
22
Index case for the fungal meningitis outbreak, United States. ( 23465120 )
2013
23
Fungal meningitis outbreak. ( 23358084 )
2013
24
Vascular complications of fungal meningitis attributed to injections of contaminated methylprednisolone acetate. ( 23877880 )
2013
25
Fungal meningitis in an immunocompetent patient. ( 23381985 )
2013
26
Vogt-koyanagi-harada disease and fungal meningitis. ( 25383811 )
2013
27
Cerebrospinal fluid (1,3)-I^-D-glucan detection as an aid for diagnosis of iatrogenic fungal meningitis. ( 23363831 )
2013
28
Iatrogenic fungal meningitis. ( 23460069 )
2013
29
Early clinical observations in prospectively followed patients with fungal meningitis related to contaminated epidural steroid injections. ( 23183583 )
2013
30
Insights into fungal pathogenesis from the iatrogenic epidemic of Exserohilum rostratum fungal meningitis. ( 24012946 )
2013
31
Index case for the fungal meningitis outbreak, United States. ( 23465121 )
2013
32
Index case for the fungal meningitis outbreak, United States. ( 23465119 )
2013
33
Detection of fungal DNA in human body fluids and tissues during a multistate outbreak of fungal meningitis and other infections. ( 23457192 )
2013
34
Hospital faces uncertainty as it copes with surge of patients with fungal meningitis. ( 23321741 )
2013
35
Notes from the field: Department of Defense response to a multistate outbreak of fungal meningitis--United States, October 2012. ( 24067586 )
2013
36
The fungal meningitis tragedy: implications for pharmacy education and the profession. ( 23460756 )
2013
37
The index case for the fungal meningitis outbreak in the United States. ( 23083311 )
2012
38
Multistate fungal meningitis outbreak -- interim guidance for treatment. ( 23076094 )
2012
39
Fungal meningitis from injection of contaminated steroids: a compounding problem. ( 23104261 )
2012
40
Fungal meningitis due to contaminated epidural steroid injections. ( 23221857 )
2012
41
Chronic fungal meningitis caused by Aureobasidium proteae. ( 22504065 )
2012
42
Iatrogenic fungal meningitis: tragedy repeated. ( 23080380 )
2012
43
Bacterial and fungal meningitis and antimicrobial susceptibility pattern in Tikur Anbessa University Hospital, Addis Ababa, Ethiopia. ( 23409400 )
2011
44
Assessment of a real-time PCR method to detect human non-cryptococcal fungal meningitis. ( 22039841 )
2011
45
A new method for the treatment of chronic fungal meningitis: continuous infusion into the cerebrospinal fluid for coccidioidal meningitis. ( 19506457 )
2009
46
Bacterial and fungal meningitis in patients with cancer. ( 18347316 )
2008
47
Epidemiologic and microbiologic characteristics of recurrent bacterial and fungal meningitis in the Netherlands, 1988-2005. ( 18643757 )
2008
48
Life-threatening fungal meningitis-ventriculitis secondary to vaginal candidiasis. ( 17554958 )
2007
49
World's first reported outbreak of iatrogenic fungal meningitis. ( 17802991 )
2007
50
Prevalence of fungal meningitis among HIV positive & negative subjects in Indore (MP state). ( 12645168 )
2002

Variations for Fungal Meningitis

Expression for Fungal Meningitis

Search GEO for disease gene expression data for Fungal Meningitis.

Pathways for Fungal Meningitis

Pathways related to Fungal Meningitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.65 CXCL10 IFNG IRF6
2 10.19 CXCL10 IFNG

GO Terms for Fungal Meningitis

Biological processes related to Fungal Meningitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 interferon-gamma-mediated signaling pathway GO:0060333 8.96 IFNG IRF6
2 regulation of insulin secretion GO:0050796 8.62 CARTPT IFNG

Sources for Fungal Meningitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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