MCID: FNG004
MIFTS: 32

Fungal Meningitis

Categories: Neuronal diseases

Aliases & Classifications for Fungal Meningitis

MalaCards integrated aliases for Fungal Meningitis:

Name: Fungal Meningitis 12 3 14
Meningitis, Fungal 42 69

Classifications:



External Ids:

Disease Ontology 12 DOID:11608
MeSH 42 D016921
SNOMED-CT 64 24321005
UMLS 69 C0085438

Summaries for Fungal Meningitis

Disease Ontology : 12 A meningitis that has material basis in a fungal infection.

MalaCards based summary : Fungal Meningitis, also known as meningitis, fungal, is related to cryptococcal meningitis and dieulafoy lesion. An important gene associated with Fungal Meningitis is IFNG (Interferon Gamma), and among its related pathways/superpathways are NF-kappaB Signaling and Type II interferon signaling (IFNG). The drugs Fluconazole and Miconazole have been mentioned in the context of this disorder. Affiliated tissues include brain, bone and testes, and related phenotype is cardiovascular system.

CDC : 3 Español: Meningitis micótica

Wikipedia : 72 Fungal meningitis refers to meningitis caused by a fungal... more...

Related Diseases for Fungal Meningitis

Graphical network of the top 20 diseases related to Fungal Meningitis:



Diseases related to Fungal Meningitis

Symptoms & Phenotypes for Fungal Meningitis

MGI Mouse Phenotypes related to Fungal Meningitis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.1 CXCL10 FLNC GPR180 IFNG TRIM37 UNC119

Drugs & Therapeutics for Fungal Meningitis

Drugs for Fungal Meningitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 68)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fluconazole Approved Phase 4,Phase 3,Phase 2,Phase 1 86386-73-4 3365
2
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 22916-47-8 4189
3
Amphotericin B Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 1397-89-3 14956 5280965
4
Efavirenz Approved, Investigational Phase 4 154598-52-4 64139
5
Lamivudine Approved, Investigational Phase 4 134678-17-4 60825
6
Stavudine Approved, Investigational Phase 4 3056-17-5 18283
7
Zidovudine Approved Phase 4 30516-87-1 35370
8 Antifungal Agents Phase 4,Phase 3,Phase 2,Phase 1
9 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1
10 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Phase 1
11 Antiparasitic Agents Phase 4,Phase 3,Phase 2,Phase 1
12 Antiprotozoal Agents Phase 4,Phase 3,Phase 2,Phase 1
13 Liposomal amphotericin B Phase 4,Phase 3,Phase 2,Phase 1
14 Cytochrome P-450 CYP2C9 Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
15 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
16 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1
17 Hormones Phase 4,Phase 3,Phase 2,Phase 1
18 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1
19 Steroid Synthesis Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
20 Anti-HIV Agents Phase 4
21 Anti-Retroviral Agents Phase 4
22 Antiviral Agents Phase 4,Phase 2
23 Cytochrome P-450 CYP3A Inducers Phase 4
24 Nucleic Acid Synthesis Inhibitors Phase 4
25 Reverse Transcriptase Inhibitors Phase 4
26
Flucytosine Approved Phase 2, Phase 3 2022-85-7 3366
27
Clotrimazole Approved, Vet_approved Phase 3 23593-75-1 2812
28
Sertraline Approved Phase 3 79617-96-2 68617
29 Antimetabolites Phase 2, Phase 3
30 Antidepressive Agents Phase 3
31 Neurotransmitter Agents Phase 3
32 Neurotransmitter Uptake Inhibitors Phase 3
33 Psychotropic Drugs Phase 3
34
Serotonin Phase 3 50-67-9 5202
35 Serotonin Agents Phase 3
36 Serotonin Uptake Inhibitors Phase 3
37
deoxycholic acid Approved Phase 1, Phase 2 83-44-3 222528
38
Itraconazole Approved, Investigational Phase 2 84625-61-6 55283
39
Dexamethasone Approved, Investigational, Vet_approved Phase 2 50-02-2 5743
40
Tamoxifen Approved Phase 2 10540-29-1 2733526
41 Amphotericin B, deoxycholate drug combination Phase 1, Phase 2
42 Gastrointestinal Agents Phase 2
43 Cytochrome P-450 CYP3A Inhibitors Phase 2
44 Hydroxyitraconazole Phase 2
45 Antiemetics Phase 2
46 Anti-Inflammatory Agents Phase 2
47 Antineoplastic Agents, Hormonal Phase 2
48 Autonomic Agents Phase 2
49 BB 1101 Phase 2
50 Dexamethasone acetate Phase 2 1177-87-3

Interventional clinical trials:

(show all 42)

id Name Status NCT ID Phase Drugs
1 Operational Research for Cryptococcal Antigen Screening Completed NCT01535469 Phase 4 Fluconazole
2 Optimal Time to Start Antiretroviral Therapy in HIV-infected Adults With Cryptococcal Meningitis Completed NCT00976040 Phase 4
3 Cryptococcal Optimal ART Timing Trial Completed NCT01075152 Phase 4 efavirenz
4 Efficacy of Intrathecal Administration of Liposomal Amphotericin B in Cryptococcal Meningitis Not yet recruiting NCT02686853 Phase 4 Liposomal amphotericin B
5 Randomized Comparative Study of Fluconazole Versus Clotrimazole Troches in the Prevention of Serious Fungal Infection in Patients With AIDS or Advanced AIDS-Related Complex. (A Nested Study of ACTG 081) Completed NCT00000676 Phase 3 Clotrimazole;Fluconazole
6 Comparison of Fluconazole and Amphotericin B in the Treatment of Brain Infections in Patients With AIDS Completed NCT00001017 Phase 3 Fluconazole;Amphotericin B
7 Cryptococcal Antigen Screening Plus Sertraline Recruiting NCT03002012 Phase 3 Sertraline;Placebo Oral Tablet;Fluconazole
8 Adjunctive Sertraline for the Treatment of HIV-Associated Cryptococcal Meningitis Active, not recruiting NCT01802385 Phase 3 Sertraline
9 Study Evaluating Efficiency and Tolerance of High-dose Fluconazole Associated With Flucytosine as Induction Therapy for Cryptococcal Meningitis Associated With HIV in Sub-saharan Africa Active, not recruiting NCT01715922 Phase 2, Phase 3 Fluconazole;Flucytosine
10 Amphotericin Alone or in Combination With Fluconazole for AIDS-Associated Meningitis Completed NCT00145249 Phase 2 Amphotericin B;Fluconazole
11 High-Dose Fluconazole for the Treatment of Cryptococcal Meningitis in HIV-Infected Individuals Completed NCT00885703 Phase 1, Phase 2 Fluconazole;Amphotericin B
12 A Study of Itraconazole in the Treatment and Prevention of Histoplasmosis, a Fungal Infection, in Patients With AIDS Completed NCT00000975 Phase 2 Itraconazole
13 Dexamethasone in Cryptococcal Meningitis Completed NCT00000776 Phase 2 Flucytosine;Fluconazole;Amphotericin B;Dexamethasone
14 Safety and Antifungal Activity of Recombinant Interferon-Gamma 1b (rIFN-Gamma 1b) Given With Standard Therapy in Patients With Cryptococcal Meningitis Completed NCT00012467 Phase 2 Itraconazole;Flucytosine;Fluconazole;Amphotericin B;Interferon gamma-1b
15 Treatment With Tamoxifen in Cryptococcal Meningitis Not yet recruiting NCT03112031 Phase 2 Tamoxifen;Amphotericin B;Fluconazole
16 Efficacy and Safety of Mycograb as Adjunctive Therapy for Cryptococcal Meningitis in Patients With AIDS Terminated NCT00847678 Phase 2
17 Efficacy and Safety of Mycograb as Adjunctive Therapy for Cryptococcal Meningitis in Patients With AIDS Terminated NCT00324025 Phase 2 Mycograb;placebo
18 SCH 39304 as Therapy for Acute Cryptococcal Meningitis in HIV-Infected Patients Followed by Maintenance Therapy Completed NCT00000677 Phase 1 SCH 39304
19 The Safety and Effectiveness of RMP-7 Plus Amphotericin B in Patients With HIV and Cryptococcal Meningitis Completed NCT00002316 Phase 1 Lobradimil;Amphotericin B
20 Vietnam Cryptococcal Retention in Care Study (CRICS) Federal Financial Report Recruiting NCT02955862 Phase 1
21 Liposomal Amphotericin B for the Treatment of Cryptococcal Meningitis Unknown status NCT02136030 Liposomal amphotericin B;Amphotericin B-deoxycholate
22 Early Versus Delayed Antiretroviral Therapy (ART) in the Treatment of Cryptococcal Meningitis in Africa Completed NCT00830856 Fluconazole;Fixed dose - Stavudine, lamivudine and Nevirapine;Fixed dose - Stavudine, Lamivudine, Nevirapine
23 Clinical Outcomes of Cryptococcal Meningitis Among HIV-infected Patients in the Era of Antiretroviral Therapy Completed NCT02098525
24 Multi-center Comparison of Fluconazole (UK-49,858) and Amphotericin B as Treatment for Acute Cryptococcal Meningitis Completed NCT00000708 Flucytosine;Fluconazole;Amphotericin B
25 Pilot Study of Oral Fluconazole in the Treatment of Acute Cryptococcal Meningitis Completed NCT00002076 Fluconazole
26 A Comparison of Fluconazole and Amphotericin B in the Treatment of Cryptococcal Meningitis Completed NCT00002305 Flucytosine;Fluconazole;Amphotericin B
27 Multicenter Comparison of Fluconazole (UK-49,858) and Amphotericin B as Treatment for Acute Cryptococcal Meningitis Completed NCT00002075 Flucytosine;Fluconazole;Amphotericin B
28 A Multicenter Comparison of Fluconazole (UK-49,858) and Amphotericin B as Treatment for Acute Cryptococcal Meningitis Completed NCT00002068 Fluconazole;Amphotericin B
29 A Randomized Double Blind Protocol Comparing Amphotericin B With Flucytosine to Amphotericin B Alone Followed by a Comparison of Fluconazole and Itraconazole in the Treatment of Acute Cryptococcal Meningitis Completed NCT00000639 Itraconazole;Flucytosine;Fluconazole;Amphotericin B
30 A Study of Fluconazole in the Treatment of Cryptococcal Meningitis in Patients Who Have Not Had Success With Amphotericin B Completed NCT00002306 Fluconazole
31 A Study of Fluconazole in the Treatment of Cryptococcal Meningitis in Patients With AIDS Completed NCT00002294 Fluconazole
32 A Pilot Study of Fluconazole Plus Flucytosine for the Treatment of AIDS Patients With Acute Cryptococcal Meningitis. Completed NCT00002113 Flucytosine;Fluconazole
33 An Open, Non-Comparative Study of Intravenous and Oral Fluconazole in the Treatment of Acute Cryptococcal Meningitis Completed NCT00002077 Fluconazole
34 Open, Non-Comparative Study of Intravenous and Oral Fluconazole in the Treatment of Acute Cryptococcal Meningitis Completed NCT00002040 Fluconazole
35 Safety and Efficacy of Amphotericin B Lipid Complex in the Treatment of Cryptococcal Meningitis in Patients With the Acquired Immunodeficiency Syndrome Completed NCT00002019 Amphotericin B, Lipid-based;Amphotericin B
36 Multicenter Comparison of Fluconazole (UK-49,858) and Amphotericin B as Maintenance Treatment for the Prevention of Relapse of Cryptococcal Meningitis in Patients With Acquired Immunodeficiency Syndrome Completed NCT00002074 Fluconazole;Amphotericin B
37 Pre-Antiretroviral Therapy (ART) Cryptococcal Antigen Screening in AIDS Recruiting NCT02624453 Fluconazole;Antiretroviral therapy
38 CryptoART Study: Decreasing Mortality Associated With Initiation of Antiretroviral Therapy in Sub-Saharan Africa Active, not recruiting NCT02434172
39 The Study of Voriconazole Trough Level in the First Two Weeks After Administration in King Chulalongkorn Memorial Hospital. Active, not recruiting NCT03260634 Voriconazole
40 Vietnam Cryptococcal Retention in Care Study Version 1.0 Active, not recruiting NCT02334670 Fluconazole
41 Prevalence of Pathogens in Cerebrospinal Fluid Obtained From Emergency Department Patients Active, not recruiting NCT02207647
42 Vietnam Cryptococcal Retention in Care Study - Version 2.1 Active, not recruiting NCT03267407

Search NIH Clinical Center for Fungal Meningitis

Cochrane evidence based reviews: meningitis, fungal

Genetic Tests for Fungal Meningitis

Anatomical Context for Fungal Meningitis

MalaCards organs/tissues related to Fungal Meningitis:

39
Brain, Bone, Testes

Publications for Fungal Meningitis

Articles related to Fungal Meningitis:

(show top 50) (show all 67)
id Title Authors Year
1
Epidemiological Effectiveness and Cost of a Fungal Meningitis Outbreak Response in New River Valley, Virginia: Local Health Department and Clinical Perspectives. ( 28578748 )
2017
2
Clinical Response, Outbreak Investigation, and Epidemiology of the Fungal Meningitis Epidemic in the United States: Systematic Review. ( 26681583 )
2016
3
Fungal meningitis caused by Lomentospora prolificans after allogeneic hematopoietic stem cell transplantation. ( 27258644 )
2016
4
Utility of real-time PCR for detection of Exserohilum rostratum in body and tissue fluids during the multistate outbreak of fungal meningitis and other infections. ( 25520443 )
2015
5
Economic Evaluation of Fungal Meningitis Outbreak Response in New River Valley: Local Health Department Perspective. ( 26317059 )
2015
6
Estimated deaths and illnesses averted during fungal meningitis outbreak associated with contaminated steroid injections, United States, 2012-2013. ( 25989264 )
2015
7
Lack of IL-6 increases blood-brain barrier permeability in fungal meningitis. ( 25740137 )
2015
8
Causes and root causes of a multistate fungal meningitis outbreak. ( 25616150 )
2015
9
(1,3)-I^-d-glucan in cerebrospinal fluid for diagnosis of fungal meningitis associated with contaminated methylprednisolone injections. ( 25540391 )
2015
10
Fungal meningitis in England and Wales. ( 25253404 )
2014
11
How gaps in regulation of compounding pharmacy set the stage for a multistate fungal meningitis outbreak. ( 25063265 )
2014
12
Unraveling the biology of a fungal meningitis pathogen using chemical genetics. ( 25416953 )
2014
13
Utility of (1-3)-I^-D-Glucan Testing for Diagnostics and Monitoring Response to Treatment During the Multistate Outbreak of Fungal Meningitis and Other Infections. ( 24336827 )
2014
14
Trends in bacterial, mycobacterial, and fungal meningitis in England and Wales 2004-11: an observational study. ( 24508198 )
2014
15
Whole-genome analysis of Exserohilum rostratum from an outbreak of fungal meningitis and other infections. ( 24951807 )
2014
16
A real-time PCR assay for rapid detection and quantification of Exserohilum rostratum, a causative pathogen of fungal meningitis associated with injection of contaminated methylprednisolone. ( 23303500 )
2013
17
Detection of fungal DNA in human body fluids and tissues during a multistate outbreak of fungal meningitis and other infections. ( 23457192 )
2013
18
Insights into fungal pathogenesis from the iatrogenic epidemic of Exserohilum rostratum fungal meningitis. ( 24012946 )
2013
19
Notes from the field: Department of Defense response to a multistate outbreak of fungal meningitis--United States, October 2012. ( 24067586 )
2013
20
Exserohilum rostratum fungal meningitis associated with methylprednisolone injections. ( 23374119 )
2013
21
Index case for the fungal meningitis outbreak, United States. ( 23465119 )
2013
22
Index case for the fungal meningitis outbreak, United States. ( 23465120 )
2013
23
Early clinical observations in prospectively followed patients with fungal meningitis related to contaminated epidural steroid injections. ( 23183583 )
2013
24
Cerebrospinal fluid (1,3)-I^-D-glucan detection as an aid for diagnosis of iatrogenic fungal meningitis. ( 23363831 )
2013
25
Fungal meningitis outbreak. ( 23358084 )
2013
26
Relapse of fungal meningitis associated with contaminated methylprednisolone. ( 23718153 )
2013
27
Fungal meningitis outbreak editorial. ( 24095660 )
2013
28
Hospital faces uncertainty as it copes with surge of patients with fungal meningitis. ( 23321741 )
2013
29
Index case for the fungal meningitis outbreak, United States. ( 23465121 )
2013
30
The fungal meningitis tragedy: implications for pharmacy education and the profession. ( 23460756 )
2013
31
Fungal meningitis in an immunocompetent patient. ( 23381985 )
2013
32
Vascular complications of fungal meningitis attributed to injections of contaminated methylprednisolone acetate. ( 23877880 )
2013
33
Iatrogenic fungal meningitis. ( 23460069 )
2013
34
Vogt-koyanagi-harada disease and fungal meningitis. ( 25383811 )
2013
35
Fungal meningitis outbreak affects over 700. ( 23602160 )
2013
36
Multistate fungal meningitis outbreak -- interim guidance for treatment. ( 23076094 )
2012
37
Fungal meningitis due to contaminated epidural steroid injections. ( 23221857 )
2012
38
Chronic fungal meningitis caused by Aureobasidium proteae. ( 22504065 )
2012
39
Fungal meningitis from injection of contaminated steroids: a compounding problem. ( 23104261 )
2012
40
The index case for the fungal meningitis outbreak in the United States. ( 23083311 )
2012
41
Iatrogenic fungal meningitis: tragedy repeated. ( 23080380 )
2012
42
Assessment of a real-time PCR method to detect human non-cryptococcal fungal meningitis. ( 22039841 )
2011
43
Bacterial and fungal meningitis and antimicrobial susceptibility pattern in Tikur Anbessa University Hospital, Addis Ababa, Ethiopia. ( 23409400 )
2011
44
A new method for the treatment of chronic fungal meningitis: continuous infusion into the cerebrospinal fluid for coccidioidal meningitis. ( 19506457 )
2009
45
Epidemiologic and microbiologic characteristics of recurrent bacterial and fungal meningitis in the Netherlands, 1988-2005. ( 18643757 )
2008
46
Bacterial and fungal meningitis in patients with cancer. ( 18347316 )
2008
47
World's first reported outbreak of iatrogenic fungal meningitis. ( 17802991 )
2007
48
Life-threatening fungal meningitis-ventriculitis secondary to vaginal candidiasis. ( 17554958 )
2007
49
Prevalence of fungal meningitis among HIV positive & negative subjects in Indore (MP state). ( 12645168 )
2002
50
Spinal seeding of anaplastic ependymoma mimicking fungal meningitis. A case report and review of the literature. ( 10961497 )
2000

Variations for Fungal Meningitis

Expression for Fungal Meningitis

Search GEO for disease gene expression data for Fungal Meningitis.

Pathways for Fungal Meningitis

Pathways related to Fungal Meningitis according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.63 CXCL10 IFNG IRF6
2 10.19 CXCL10 IFNG

GO Terms for Fungal Meningitis

Biological processes related to Fungal Meningitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 interferon-gamma-mediated signaling pathway GO:0060333 8.96 IFNG IRF6
2 regulation of insulin secretion GO:0050796 8.62 CARTPT IFNG

Sources for Fungal Meningitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....